ZNF813

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of DNA-dependent DNA replication (GO:2000104)4.26315131
2replication fork processing (GO:0031297)4.01488049
3chromatin remodeling at centromere (GO:0031055)3.86798403
4regulation of nuclear cell cycle DNA replication (GO:0033262)3.84877031
5DNA double-strand break processing (GO:0000729)3.70767001
6regulation of posttranscriptional gene silencing (GO:0060147)3.62378483
7regulation of gene silencing by miRNA (GO:0060964)3.62378483
8regulation of gene silencing by RNA (GO:0060966)3.62378483
9water-soluble vitamin biosynthetic process (GO:0042364)3.61718796
10behavioral response to nicotine (GO:0035095)3.53105853
11CENP-A containing nucleosome assembly (GO:0034080)3.45009916
12regulation of translation, ncRNA-mediated (GO:0045974)3.40905289
13negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.40905289
14negative regulation of translation, ncRNA-mediated (GO:0040033)3.40905289
15response to pheromone (GO:0019236)3.40470077
16L-fucose catabolic process (GO:0042355)3.30928420
17fucose catabolic process (GO:0019317)3.30928420
18L-fucose metabolic process (GO:0042354)3.30928420
19nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.27968625
20RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.26426470
21platelet dense granule organization (GO:0060155)3.24052367
22regulation of mitotic spindle checkpoint (GO:1903504)3.22479132
23regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.22479132
24respiratory chain complex IV assembly (GO:0008535)3.21417541
25exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.19307874
26ncRNA catabolic process (GO:0034661)3.12815552
27histone exchange (GO:0043486)3.09897946
28double-strand break repair via homologous recombination (GO:0000724)3.09092091
29recombinational repair (GO:0000725)3.08655879
30epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.05029525
31somatic diversification of immune receptors via somatic mutation (GO:0002566)3.02869095
32somatic hypermutation of immunoglobulin genes (GO:0016446)3.02869095
33single strand break repair (GO:0000012)3.00675869
34regulation of DNA endoreduplication (GO:0032875)2.97669213
35rRNA catabolic process (GO:0016075)2.97364848
36pseudouridine synthesis (GO:0001522)2.95198412
37maturation of 5.8S rRNA (GO:0000460)2.95161140
38maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.93200794
39epithelial cilium movement (GO:0003351)2.92466273
40centriole replication (GO:0007099)2.92055606
41protein K6-linked ubiquitination (GO:0085020)2.91052056
42cytochrome complex assembly (GO:0017004)2.88963906
43tryptophan catabolic process (GO:0006569)2.88116172
44indole-containing compound catabolic process (GO:0042436)2.88116172
45indolalkylamine catabolic process (GO:0046218)2.88116172
46resolution of meiotic recombination intermediates (GO:0000712)2.86028043
47regulation of mesoderm development (GO:2000380)2.83722160
48DNA replication checkpoint (GO:0000076)2.81474176
49kynurenine metabolic process (GO:0070189)2.80331055
50peptidyl-histidine modification (GO:0018202)2.80310429
51reciprocal DNA recombination (GO:0035825)2.78558062
52reciprocal meiotic recombination (GO:0007131)2.78558062
53synapsis (GO:0007129)2.77759669
54establishment of protein localization to mitochondrial membrane (GO:0090151)2.77275162
55DNA replication-dependent nucleosome assembly (GO:0006335)2.76740360
56DNA replication-dependent nucleosome organization (GO:0034723)2.76740360
57negative regulation of telomere maintenance (GO:0032205)2.76729855
58DNA replication-independent nucleosome assembly (GO:0006336)2.72284145
59DNA replication-independent nucleosome organization (GO:0034724)2.72284145
60neural tube formation (GO:0001841)2.71570160
61regulation of centriole replication (GO:0046599)2.71407209
62protein complex biogenesis (GO:0070271)2.70458676
63histone mRNA metabolic process (GO:0008334)2.69445332
64protein-cofactor linkage (GO:0018065)2.68626613
65regulation of meiosis I (GO:0060631)2.67080169
66indolalkylamine metabolic process (GO:0006586)2.67028162
67DNA deamination (GO:0045006)2.66964000
68kidney morphogenesis (GO:0060993)2.66058811
69mitochondrial respiratory chain complex assembly (GO:0033108)2.64816442
70nonmotile primary cilium assembly (GO:0035058)2.62980765
71detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.62068775
72photoreceptor cell maintenance (GO:0045494)2.61280232
73protein neddylation (GO:0045116)2.60303091
74meiotic chromosome segregation (GO:0045132)2.60141154
75somite rostral/caudal axis specification (GO:0032525)2.57337380
76NADH dehydrogenase complex assembly (GO:0010257)2.56984606
77mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.56984606
78mitochondrial respiratory chain complex I assembly (GO:0032981)2.56984606
79protein K11-linked deubiquitination (GO:0035871)2.56484991
80somite development (GO:0061053)2.56363786
81cellular ketone body metabolic process (GO:0046950)2.54479899
82regulation of telomere maintenance (GO:0032204)2.51436867
83intraciliary transport (GO:0042073)2.51066850
84negative regulation of transcription regulatory region DNA binding (GO:2000678)2.50424799
85regulation of helicase activity (GO:0051095)2.50216486
86regulation of cilium movement (GO:0003352)2.48963311
87DNA strand renaturation (GO:0000733)2.47235747
88postreplication repair (GO:0006301)2.47069958
89cilium morphogenesis (GO:0060271)2.46320817
90regulation of glucokinase activity (GO:0033131)2.45545402
91regulation of hexokinase activity (GO:1903299)2.45545402
92somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.45490057
93isotype switching (GO:0045190)2.45490057
94somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.45490057
95protein polyglutamylation (GO:0018095)2.44736225
96piRNA metabolic process (GO:0034587)2.44570013
97axoneme assembly (GO:0035082)2.44016505
98tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.39767753
99RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.39767753
100presynaptic membrane organization (GO:0097090)2.39112918

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.59909061
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.08587855
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.87553360
4VDR_22108803_ChIP-Seq_LS180_Human2.86233152
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.75244492
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.67154514
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.66716199
8EWS_26573619_Chip-Seq_HEK293_Human2.48314504
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.47601338
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.45022314
11FUS_26573619_Chip-Seq_HEK293_Human2.40725269
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.34762397
13IGF1R_20145208_ChIP-Seq_DFB_Human2.33143697
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.32064938
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.25942179
16ELK1_19687146_ChIP-ChIP_HELA_Human2.18500473
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.15806261
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.14583665
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.12355565
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.05826343
21P300_19829295_ChIP-Seq_ESCs_Human2.05081184
22GBX2_23144817_ChIP-Seq_PC3_Human2.05021966
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.94348911
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.91060788
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88892256
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.88879035
27TAF15_26573619_Chip-Seq_HEK293_Human1.81488292
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79421022
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76255693
30POU5F1_16153702_ChIP-ChIP_HESCs_Human1.75074833
31MYC_18940864_ChIP-ChIP_HL60_Human1.74894655
32IRF1_19129219_ChIP-ChIP_H3396_Human1.70735059
33VDR_23849224_ChIP-Seq_CD4+_Human1.64191110
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57562661
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56415073
36PCGF2_27294783_Chip-Seq_NPCs_Mouse1.54062306
37ER_23166858_ChIP-Seq_MCF-7_Human1.53282127
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50136096
39CBP_20019798_ChIP-Seq_JUKART_Human1.48725348
40IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48725348
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48414457
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.46458181
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42340647
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38321556
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.36846514
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.36477905
47E2F7_22180533_ChIP-Seq_HELA_Human1.34401091
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33809702
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32425365
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.31437913
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31011502
52KLF5_20875108_ChIP-Seq_MESCs_Mouse1.30849767
53ETS1_20019798_ChIP-Seq_JURKAT_Human1.30179958
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29984120
55FOXP3_21729870_ChIP-Seq_TREG_Human1.28927062
56TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28207653
57POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28207653
58GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26830550
59TP53_22573176_ChIP-Seq_HFKS_Human1.26144886
60NANOG_19829295_ChIP-Seq_ESCs_Human1.26109986
61SOX2_19829295_ChIP-Seq_ESCs_Human1.26109986
62SOX2_16153702_ChIP-ChIP_HESCs_Human1.25601066
63SMAD4_21799915_ChIP-Seq_A2780_Human1.24363990
64BCAT_22108803_ChIP-Seq_LS180_Human1.21886953
65* STAT3_23295773_ChIP-Seq_U87_Human1.21781435
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20921798
67TCF4_22108803_ChIP-Seq_LS180_Human1.18748854
68KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16982468
69TCF4_23295773_ChIP-Seq_U87_Human1.16919145
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.16623293
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15138954
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15062567
73ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.14299275
74FOXA1_25329375_ChIP-Seq_VCAP_Human1.10470976
75FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10470976
76NANOG_16153702_ChIP-ChIP_HESCs_Human1.10214828
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08475440
78FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.07517614
79JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.07018449
80AR_25329375_ChIP-Seq_VCAP_Human1.06032624
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05562955
82CRX_20693478_ChIP-Seq_RETINA_Mouse1.04999809
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04910966
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04603789
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04388183
86CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03698293
87RUNX2_22187159_ChIP-Seq_PCA_Human1.03031533
88BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02738276
89FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99680014
90NANOG_18555785_Chip-Seq_ESCs_Mouse0.99668998
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99402722
92CREB1_15753290_ChIP-ChIP_HEK293T_Human0.99122975
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98551783
94SRF_21415370_ChIP-Seq_HL-1_Mouse0.97372927
95SMAD4_21741376_ChIP-Seq_EPCs_Human0.96687858
96RNF2_27304074_Chip-Seq_NSC_Mouse0.96441084
97AR_20517297_ChIP-Seq_VCAP_Human0.94420188
98P53_22387025_ChIP-Seq_ESCs_Mouse0.94107492
99CDX2_22108803_ChIP-Seq_LS180_Human0.93637265
100STAT3_18555785_Chip-Seq_ESCs_Mouse0.92371801

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.90855819
2MP0006292_abnormal_olfactory_placode3.42838728
3MP0002102_abnormal_ear_morphology3.01407587
4MP0003787_abnormal_imprinting2.97933536
5MP0003890_abnormal_embryonic-extraembry2.66052815
6MP0003195_calcinosis2.59374685
7MP0008058_abnormal_DNA_repair2.36496392
8MP0003693_abnormal_embryo_hatching2.20994370
9MP0006072_abnormal_retinal_apoptosis2.08046229
10MP0001293_anophthalmia2.07343206
11MP0004133_heterotaxia2.04036014
12MP0003718_maternal_effect1.97265602
13MP0010094_abnormal_chromosome_stability1.89799469
14MP0002254_reproductive_system_inflammat1.88630320
15MP0005551_abnormal_eye_electrophysiolog1.86250290
16MP0001188_hyperpigmentation1.85778666
17MP0008057_abnormal_DNA_replication1.84917554
18MP0003121_genomic_imprinting1.78333772
19MP0008789_abnormal_olfactory_epithelium1.73703287
20MP0001529_abnormal_vocalization1.72794649
21MP0003567_abnormal_fetal_cardiomyocyte1.70669273
22MP0003941_abnormal_skin_development1.59731065
23MP0002938_white_spotting1.58616073
24MP0001485_abnormal_pinna_reflex1.58483578
25MP0002163_abnormal_gland_morphology1.56493411
26MP0003119_abnormal_digestive_system1.56478692
27MP0005379_endocrine/exocrine_gland_phen1.56332487
28MP0003937_abnormal_limbs/digits/tail_de1.54300861
29MP0003122_maternal_imprinting1.53728927
30MP0005253_abnormal_eye_physiology1.51572248
31MP0002638_abnormal_pupillary_reflex1.45644815
32MP0003646_muscle_fatigue1.43812031
33MP0005394_taste/olfaction_phenotype1.43010392
34MP0005499_abnormal_olfactory_system1.43010392
35MP0000631_abnormal_neuroendocrine_gland1.38179084
36MP0006276_abnormal_autonomic_nervous1.36491730
37MP0005646_abnormal_pituitary_gland1.35776844
38MP0001984_abnormal_olfaction1.33282175
39MP0000383_abnormal_hair_follicle1.29528832
40MP0003011_delayed_dark_adaptation1.27507462
41MP0005084_abnormal_gallbladder_morpholo1.27312895
42MP0000427_abnormal_hair_cycle1.27058945
43MP0002837_dystrophic_cardiac_calcinosis1.26671222
44MP0005075_abnormal_melanosome_morpholog1.25407363
45MP0003136_yellow_coat_color1.23140120
46MP0005645_abnormal_hypothalamus_physiol1.22047552
47MP0002138_abnormal_hepatobiliary_system1.20162388
48MP0003880_abnormal_central_pattern1.18809239
49MP0001968_abnormal_touch/_nociception1.18298809
50MP0001286_abnormal_eye_development1.16543349
51MP0002160_abnormal_reproductive_system1.15780107
52MP0002736_abnormal_nociception_after1.13374466
53MP0009697_abnormal_copulation1.13163775
54MP0008995_early_reproductive_senescence1.12663216
55MP0002210_abnormal_sex_determination1.12170896
56MP0001764_abnormal_homeostasis1.09556075
57MP0002653_abnormal_ependyma_morphology1.09241011
58MP0004147_increased_porphyrin_level1.08772381
59MP0004957_abnormal_blastocyst_morpholog1.08188127
60MP0000372_irregular_coat_pigmentation1.08127079
61MP0002233_abnormal_nose_morphology1.07699789
62MP0005389_reproductive_system_phenotype1.07502430
63MP0001929_abnormal_gametogenesis1.06141560
64MP0004142_abnormal_muscle_tone1.05735361
65MP0009046_muscle_twitch1.05378165
66MP0005174_abnormal_tail_pigmentation1.04980504
67MP0001145_abnormal_male_reproductive1.03020762
68MP0000653_abnormal_sex_gland1.01953678
69MP0003111_abnormal_nucleus_morphology1.01573680
70MP0008872_abnormal_physiological_respon0.99899491
71MP0002234_abnormal_pharynx_morphology0.99254863
72MP0000647_abnormal_sebaceous_gland0.99137718
73MP0005195_abnormal_posterior_eye0.98710845
74MP0005377_hearing/vestibular/ear_phenot0.97627749
75MP0003878_abnormal_ear_physiology0.97627749
76MP0000516_abnormal_urinary_system0.94957965
77MP0005367_renal/urinary_system_phenotyp0.94957965
78MP0003077_abnormal_cell_cycle0.94928001
79MP0001324_abnormal_eye_pigmentation0.93965791
80MP0002751_abnormal_autonomic_nervous0.93829279
81MP0008932_abnormal_embryonic_tissue0.93139406
82MP0005391_vision/eye_phenotype0.93122403
83MP0004885_abnormal_endolymph0.92449231
84MP0005220_abnormal_exocrine_pancreas0.91185890
85MP0004043_abnormal_pH_regulation0.90483012
86MP0005423_abnormal_somatic_nervous0.87219605
87MP0001119_abnormal_female_reproductive0.87066707
88MP0003698_abnormal_male_reproductive0.85756759
89MP0003786_premature_aging0.85404430
90MP0002557_abnormal_social/conspecific_i0.84558027
91MP0006035_abnormal_mitochondrial_morpho0.83850799
92MP0000569_abnormal_digit_pigmentation0.83671048
93MP0002277_abnormal_respiratory_mucosa0.82754669
94MP0002272_abnormal_nervous_system0.82707429
95MP0003283_abnormal_digestive_organ0.81138004
96MP0009745_abnormal_behavioral_response0.80309169
97MP0001919_abnormal_reproductive_system0.79560173
98MP0002928_abnormal_bile_duct0.79496758
99MP0003123_paternal_imprinting0.79441779
100MP0002752_abnormal_somatic_nervous0.77712857

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.78791600
2Pancreatic fibrosis (HP:0100732)3.54127462
3True hermaphroditism (HP:0010459)3.38433298
4Colon cancer (HP:0003003)3.31135328
5Abnormality of midbrain morphology (HP:0002418)3.27644545
6Molar tooth sign on MRI (HP:0002419)3.27644545
7Congenital stationary night blindness (HP:0007642)2.95969342
8Abolished electroretinogram (ERG) (HP:0000550)2.91712358
9Nephronophthisis (HP:0000090)2.84849823
10Abnormality of the labia minora (HP:0012880)2.75389323
11Abnormal biliary tract physiology (HP:0012439)2.75291806
12Bile duct proliferation (HP:0001408)2.75291806
13Medial flaring of the eyebrow (HP:0010747)2.68817319
14Pendular nystagmus (HP:0012043)2.68567691
15Chronic hepatic failure (HP:0100626)2.65798221
16Hyperglycinemia (HP:0002154)2.65270516
17Abnormality of the renal medulla (HP:0100957)2.61196802
18Neoplasm of the adrenal cortex (HP:0100641)2.57470482
19Abnormality of the renal cortex (HP:0011035)2.51091284
20Septo-optic dysplasia (HP:0100842)2.41447007
21Supernumerary spleens (HP:0009799)2.39667961
22Chromsome breakage (HP:0040012)2.35930608
23Aplasia/Hypoplasia of the uvula (HP:0010293)2.35827394
24Abnormality of chromosome stability (HP:0003220)2.35546838
25Abnormality of the ileum (HP:0001549)2.34457799
26Volvulus (HP:0002580)2.33192851
27Meckel diverticulum (HP:0002245)2.30509051
28Bilateral microphthalmos (HP:0007633)2.28369119
29Anencephaly (HP:0002323)2.27597726
30Methylmalonic acidemia (HP:0002912)2.25840322
31Aplasia/Hypoplasia of the tibia (HP:0005772)2.24467043
32Intestinal atresia (HP:0011100)2.23852145
33Progressive inability to walk (HP:0002505)2.23793910
34Chromosomal breakage induced by crosslinking agents (HP:0003221)2.22495431
35Abnormal lung lobation (HP:0002101)2.21057707
36Tubular atrophy (HP:0000092)2.19692429
37Genital tract atresia (HP:0001827)2.18493527
38Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.13792752
39Vaginal atresia (HP:0000148)2.12954179
40Abnormal rod and cone electroretinograms (HP:0008323)2.12414788
41Sloping forehead (HP:0000340)2.11644062
42Cystic liver disease (HP:0006706)2.11078844
43Congenital primary aphakia (HP:0007707)2.06735331
44Anophthalmia (HP:0000528)2.06137112
45Optic nerve hypoplasia (HP:0000609)2.05702676
46Abnormality of serine family amino acid metabolism (HP:0010894)2.04469748
47Abnormality of glycine metabolism (HP:0010895)2.04469748
48Hyperglycinuria (HP:0003108)2.03036577
49Aplasia/Hypoplasia of the tongue (HP:0010295)2.01695514
50Stomach cancer (HP:0012126)2.01157528
51Attenuation of retinal blood vessels (HP:0007843)1.99246812
52Nephrogenic diabetes insipidus (HP:0009806)1.99072266
53Bifid tongue (HP:0010297)1.96666477
54Male pseudohermaphroditism (HP:0000037)1.96264220
55Abnormal pancreas size (HP:0012094)1.95585760
56Gait imbalance (HP:0002141)1.94878031
57Sclerocornea (HP:0000647)1.94550838
58Dandy-Walker malformation (HP:0001305)1.94042400
59Chorioretinal atrophy (HP:0000533)1.92622651
60Triphalangeal thumb (HP:0001199)1.92246056
61Aplasia/Hypoplasia of the spleen (HP:0010451)1.91066880
62Postaxial foot polydactyly (HP:0001830)1.88293211
63Tubulointerstitial nephritis (HP:0001970)1.86026719
64Methylmalonic aciduria (HP:0012120)1.85152000
65Inability to walk (HP:0002540)1.85136533
66Short tibia (HP:0005736)1.84869493
67Nephroblastoma (Wilms tumor) (HP:0002667)1.83785303
68Ectopic kidney (HP:0000086)1.83350509
69Abnormality of macular pigmentation (HP:0008002)1.83180571
70Embryonal renal neoplasm (HP:0011794)1.80254073
71Growth hormone deficiency (HP:0000824)1.80230703
72Renal cortical cysts (HP:0000803)1.80084604
73Asplenia (HP:0001746)1.78628346
74Abnormality of serum amino acid levels (HP:0003112)1.77813057
75Abnormality of the preputium (HP:0100587)1.76919092
76Duodenal stenosis (HP:0100867)1.76882497
77Small intestinal stenosis (HP:0012848)1.76882497
78Horseshoe kidney (HP:0000085)1.75494269
79Central scotoma (HP:0000603)1.74945835
80Increased CSF lactate (HP:0002490)1.74499968
81Aplasia/Hypoplasia of the sternum (HP:0006714)1.74402153
82Postaxial hand polydactyly (HP:0001162)1.74111564
83Abnormality of the duodenum (HP:0002246)1.74107858
84Oligodactyly (hands) (HP:0001180)1.74008072
85Absent thumb (HP:0009777)1.73934087
86Congenital hepatic fibrosis (HP:0002612)1.73881956
87Preaxial hand polydactyly (HP:0001177)1.73574089
88Abnormality of alanine metabolism (HP:0010916)1.72896986
89Hyperalaninemia (HP:0003348)1.72896986
90Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.72896986
91Hypoplasia of the fovea (HP:0007750)1.72398451
92Aplasia/Hypoplasia of the fovea (HP:0008060)1.72398451
93Pancreatic islet-cell hyperplasia (HP:0004510)1.70769006
94Abnormality of DNA repair (HP:0003254)1.70558077
95Acute necrotizing encephalopathy (HP:0006965)1.68930347
96Lipid accumulation in hepatocytes (HP:0006561)1.68267289
97Polydipsia (HP:0001959)1.68131594
98Abnormal drinking behavior (HP:0030082)1.68131594
99Poor coordination (HP:0002370)1.67821647
100Hyperventilation (HP:0002883)1.67600018

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK5.03899981
2FRK4.09592506
3BMPR1B3.09730672
4NUAK12.85610393
5MKNK22.50257907
6WNK32.47146224
7PINK12.22055587
8ACVR1B2.09216847
9EIF2AK32.05836169
10PLK42.02975555
11CDC72.01942304
12TNIK1.98093235
13STK161.96294663
14ADRBK21.93507802
15PLK31.89870011
16TRIM281.85090955
17TTK1.81533187
18MKNK11.73277413
19GRK11.68428698
20WNK41.68023522
21STK391.65058974
22MST41.61111867
23MAP4K21.59528222
24STK38L1.57600011
25BRSK21.49812645
26VRK11.44855023
27CASK1.44185511
28TAF11.35194979
29VRK21.33638630
30TAOK31.28747560
31PLK21.28362642
32OXSR11.24921363
33SRPK11.23392243
34MAP3K41.21287847
35STK31.21114289
36BUB11.13518680
37MAPK131.13290176
38DYRK21.09278637
39TGFBR11.07216469
40PLK11.05867853
41BCR1.05471963
42NLK1.03006153
43LATS11.02495924
44NEK21.01736699
45PBK0.97893118
46DYRK30.96551145
47INSRR0.93640046
48TSSK60.93425366
49TLK10.91464199
50WEE10.87796687
51NEK10.87044932
52CSNK1G10.83303450
53CHEK20.78779041
54ATR0.77560443
55AKT30.76488557
56CSNK1G20.76428587
57PRKCE0.75534328
58PASK0.68584711
59BRD40.68567457
60PRKCG0.68518119
61TIE10.68145870
62ATM0.67080714
63TXK0.65841943
64STK240.65435837
65FGFR20.65355631
66FLT30.63646362
67CSNK1G30.58118882
68RPS6KA40.58084974
69MAP2K70.53914434
70TEC0.53448383
71ADRBK10.52714975
72PAK30.50646979
73RPS6KA50.49993409
74MARK30.49580176
75CDK190.48098151
76ERBB40.47455037
77CSNK1A1L0.46711394
78PRKCQ0.45719587
79MUSK0.45164257
80EIF2AK20.44541613
81ERBB30.42423355
82EIF2AK10.42404367
83CDK30.40604062
84OBSCN0.39560809
85AURKB0.36686318
86CSNK1A10.36086873
87CSNK1E0.35547470
88PRKCI0.33648229
89CSNK2A10.30580051
90NME10.29527132
91SGK20.29464754
92CHEK10.28908740
93STK110.27994992
94BRSK10.26263045
95RPS6KB20.26132845
96CSNK1D0.24630906
97PRKDC0.24503749
98PIK3CA0.24032526
99CSNK2A20.23178668
100MAPKAPK50.22759624

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.99072514
2Homologous recombination_Homo sapiens_hsa034402.86762398
3Fanconi anemia pathway_Homo sapiens_hsa034602.83364537
4Protein export_Homo sapiens_hsa030602.55696953
5Basal transcription factors_Homo sapiens_hsa030222.33918107
6Selenocompound metabolism_Homo sapiens_hsa004502.27316645
7Non-homologous end-joining_Homo sapiens_hsa034502.26469456
8Mismatch repair_Homo sapiens_hsa034302.25726055
9RNA degradation_Homo sapiens_hsa030182.19908464
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.18958276
11Butanoate metabolism_Homo sapiens_hsa006502.14373068
12Propanoate metabolism_Homo sapiens_hsa006402.13254295
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.12190534
14Oxidative phosphorylation_Homo sapiens_hsa001902.06233513
15RNA polymerase_Homo sapiens_hsa030202.05104574
16Phototransduction_Homo sapiens_hsa047441.96684272
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.86037961
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.83327209
19One carbon pool by folate_Homo sapiens_hsa006701.81607736
20Proteasome_Homo sapiens_hsa030501.76102724
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73280252
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.65102002
23RNA transport_Homo sapiens_hsa030131.63249418
24Linoleic acid metabolism_Homo sapiens_hsa005911.62023660
25Nucleotide excision repair_Homo sapiens_hsa034201.58293922
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.58118485
27DNA replication_Homo sapiens_hsa030301.57768245
28Ribosome_Homo sapiens_hsa030101.50074964
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.48260514
30Parkinsons disease_Homo sapiens_hsa050121.44402345
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.36208411
32Tryptophan metabolism_Homo sapiens_hsa003801.33363141
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.29962681
34Ether lipid metabolism_Homo sapiens_hsa005651.29814901
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.27077040
36Nitrogen metabolism_Homo sapiens_hsa009101.26871243
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26172046
38Base excision repair_Homo sapiens_hsa034101.24019571
39Huntingtons disease_Homo sapiens_hsa050161.22963898
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22453129
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.22006025
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.20988476
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.19498653
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17989795
45Spliceosome_Homo sapiens_hsa030401.10488939
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.06472040
47Steroid biosynthesis_Homo sapiens_hsa001001.05465150
48Cell cycle_Homo sapiens_hsa041101.03711295
49Peroxisome_Homo sapiens_hsa041461.03223483
50Caffeine metabolism_Homo sapiens_hsa002321.00357917
51Collecting duct acid secretion_Homo sapiens_hsa049660.98620048
52Nicotine addiction_Homo sapiens_hsa050330.96438749
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.94996658
54Retinol metabolism_Homo sapiens_hsa008300.93355105
55Purine metabolism_Homo sapiens_hsa002300.90653253
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.90078758
57Regulation of autophagy_Homo sapiens_hsa041400.89119324
58Vitamin digestion and absorption_Homo sapiens_hsa049770.86976907
59p53 signaling pathway_Homo sapiens_hsa041150.82704771
60Olfactory transduction_Homo sapiens_hsa047400.81738258
61Pyrimidine metabolism_Homo sapiens_hsa002400.79682721
62Hedgehog signaling pathway_Homo sapiens_hsa043400.79057441
63Alzheimers disease_Homo sapiens_hsa050100.75080530
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74710968
65Basal cell carcinoma_Homo sapiens_hsa052170.72631122
66Chemical carcinogenesis_Homo sapiens_hsa052040.71704507
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71217005
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71018763
69Metabolic pathways_Homo sapiens_hsa011000.70988318
70Taste transduction_Homo sapiens_hsa047420.66056595
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64729103
72Arachidonic acid metabolism_Homo sapiens_hsa005900.61557488
73beta-Alanine metabolism_Homo sapiens_hsa004100.61478258
74Glycerolipid metabolism_Homo sapiens_hsa005610.61085706
75Glutathione metabolism_Homo sapiens_hsa004800.57133217
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56785044
77Pyruvate metabolism_Homo sapiens_hsa006200.55538052
78mRNA surveillance pathway_Homo sapiens_hsa030150.55377938
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53472426
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50464104
81Cardiac muscle contraction_Homo sapiens_hsa042600.50461192
82TGF-beta signaling pathway_Homo sapiens_hsa043500.49737863
83Fat digestion and absorption_Homo sapiens_hsa049750.48727922
84Serotonergic synapse_Homo sapiens_hsa047260.48259642
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47176138
86Fatty acid degradation_Homo sapiens_hsa000710.44001765
87Fatty acid elongation_Homo sapiens_hsa000620.43649367
88Lysine degradation_Homo sapiens_hsa003100.41598795
89Ovarian steroidogenesis_Homo sapiens_hsa049130.39017818
90ABC transporters_Homo sapiens_hsa020100.38222074
91Systemic lupus erythematosus_Homo sapiens_hsa053220.37913317
92Fatty acid metabolism_Homo sapiens_hsa012120.37269295
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36478012
94Oocyte meiosis_Homo sapiens_hsa041140.35574420
95Hippo signaling pathway_Homo sapiens_hsa043900.33038789
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.32707784
97Folate biosynthesis_Homo sapiens_hsa007900.29690932
98Insulin secretion_Homo sapiens_hsa049110.28668191
99Alcoholism_Homo sapiens_hsa050340.26103531
100Wnt signaling pathway_Homo sapiens_hsa043100.26009051

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