ZNF814

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.87368206
2negative regulation of translation, ncRNA-mediated (GO:0040033)4.87368206
3regulation of translation, ncRNA-mediated (GO:0045974)4.87368206
4behavioral response to nicotine (GO:0035095)4.81830636
5regulation of nuclear cell cycle DNA replication (GO:0033262)4.03753715
6DNA double-strand break processing (GO:0000729)3.79326461
7negative regulation of DNA-dependent DNA replication (GO:2000104)3.58595654
8respiratory chain complex IV assembly (GO:0008535)3.57626799
9regulation of gene silencing by RNA (GO:0060966)3.55418380
10regulation of posttranscriptional gene silencing (GO:0060147)3.55418380
11regulation of gene silencing by miRNA (GO:0060964)3.55418380
12replication fork processing (GO:0031297)3.41711332
13fucose catabolic process (GO:0019317)3.40882461
14L-fucose metabolic process (GO:0042354)3.40882461
15L-fucose catabolic process (GO:0042355)3.40882461
16response to pheromone (GO:0019236)3.31449908
17meiotic chromosome segregation (GO:0045132)3.29173189
18epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.23287136
19DNA replication checkpoint (GO:0000076)3.21968937
20tryptophan catabolic process (GO:0006569)3.21805451
21indole-containing compound catabolic process (GO:0042436)3.21805451
22indolalkylamine catabolic process (GO:0046218)3.21805451
23detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.19224786
24cytochrome complex assembly (GO:0017004)3.19222791
25DNA deamination (GO:0045006)3.19063386
26reciprocal meiotic recombination (GO:0007131)3.17693139
27reciprocal DNA recombination (GO:0035825)3.17693139
28DNA strand renaturation (GO:0000733)3.17680852
29detection of light stimulus involved in visual perception (GO:0050908)3.17422560
30detection of light stimulus involved in sensory perception (GO:0050962)3.17422560
31negative regulation of telomere maintenance (GO:0032205)3.17008239
32kidney morphogenesis (GO:0060993)3.16648718
33regulation of mitotic spindle checkpoint (GO:1903504)3.12072632
34regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.12072632
35recombinational repair (GO:0000725)3.11274498
36double-strand break repair via homologous recombination (GO:0000724)3.10994132
37kynurenine metabolic process (GO:0070189)3.10555134
38indolalkylamine metabolic process (GO:0006586)3.09648325
39cellular response to ATP (GO:0071318)3.06330949
40RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.05506931
41chromatin remodeling at centromere (GO:0031055)3.00485239
42water-soluble vitamin biosynthetic process (GO:0042364)2.92583664
43preassembly of GPI anchor in ER membrane (GO:0016254)2.92087726
44somatic hypermutation of immunoglobulin genes (GO:0016446)2.90300203
45somatic diversification of immune receptors via somatic mutation (GO:0002566)2.90300203
46regulation of telomere maintenance (GO:0032204)2.86597703
47regulation of hippo signaling (GO:0035330)2.86450992
48exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.85993221
49nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.85072079
50piRNA metabolic process (GO:0034587)2.83556480
51tryptophan metabolic process (GO:0006568)2.82939389
52protein complex biogenesis (GO:0070271)2.78583829
53neural tube formation (GO:0001841)2.77827888
54epithelial cilium movement (GO:0003351)2.74291780
55axoneme assembly (GO:0035082)2.72197543
56CENP-A containing nucleosome assembly (GO:0034080)2.71962346
57spinal cord motor neuron differentiation (GO:0021522)2.70131823
58cilium or flagellum-dependent cell motility (GO:0001539)2.68779060
59synapsis (GO:0007129)2.67226038
60rRNA modification (GO:0000154)2.66665108
61histone exchange (GO:0043486)2.66470719
62mitochondrial respiratory chain complex assembly (GO:0033108)2.66042804
63mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.64976484
64mitochondrial respiratory chain complex I assembly (GO:0032981)2.64976484
65NADH dehydrogenase complex assembly (GO:0010257)2.64976484
66maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.63225531
67rRNA methylation (GO:0031167)2.62587072
68L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.61670724
69cilium morphogenesis (GO:0060271)2.61242249
70cellular ketone body metabolic process (GO:0046950)2.61094786
71pseudouridine synthesis (GO:0001522)2.59463613
72DNA methylation involved in gamete generation (GO:0043046)2.59100621
73centriole replication (GO:0007099)2.58758396
74transepithelial transport (GO:0070633)2.58304723
75regulation of meiosis I (GO:0060631)2.58021317
76regulation of mesoderm development (GO:2000380)2.57336353
77protein K11-linked deubiquitination (GO:0035871)2.55764439
78negative regulation of cell aging (GO:0090344)2.53568477
79photoreceptor cell maintenance (GO:0045494)2.53538224
80mitotic cell cycle arrest (GO:0071850)2.52723276
81rRNA catabolic process (GO:0016075)2.51032922
82DNA replication-dependent nucleosome organization (GO:0034723)2.49022966
83DNA replication-dependent nucleosome assembly (GO:0006335)2.49022966
84sulfation (GO:0051923)2.48857261
85mannosylation (GO:0097502)2.47858719
86cornea development in camera-type eye (GO:0061303)2.47329248
87photoreceptor cell development (GO:0042461)2.47161188
88retinal cone cell development (GO:0046549)2.45228054
89DNA demethylation (GO:0080111)2.43036585
90platelet dense granule organization (GO:0060155)2.42932278
91DNA catabolic process, exonucleolytic (GO:0000738)2.42806989
92peptidyl-histidine modification (GO:0018202)2.40237305
93somite rostral/caudal axis specification (GO:0032525)2.39119433
94regulation of action potential (GO:0098900)2.38615267
95DNA recombination (GO:0006310)2.37393674
96cilium movement (GO:0003341)2.36462608
97ketone body metabolic process (GO:1902224)2.35924117
98ncRNA catabolic process (GO:0034661)2.35064873
99histone H3-K9 methylation (GO:0051567)2.34433624
100tRNA processing (GO:0008033)2.32066404

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.11451092
2VDR_22108803_ChIP-Seq_LS180_Human3.31854046
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.96506213
4MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.75388700
5GBX2_23144817_ChIP-Seq_PC3_Human2.72639492
6EWS_26573619_Chip-Seq_HEK293_Human2.68926039
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.65102372
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.54942794
9FUS_26573619_Chip-Seq_HEK293_Human2.49944244
10* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.34802751
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.34219548
12IGF1R_20145208_ChIP-Seq_DFB_Human2.30220998
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.26548885
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.26304324
15TAF15_26573619_Chip-Seq_HEK293_Human2.22295637
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.20566114
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.14754789
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.12247311
19EZH2_22144423_ChIP-Seq_EOC_Human2.11572359
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.06256410
21P300_19829295_ChIP-Seq_ESCs_Human2.06092756
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97465505
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.94075322
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92638799
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88178350
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.77432197
27TP63_19390658_ChIP-ChIP_HaCaT_Human1.71259553
28ER_23166858_ChIP-Seq_MCF-7_Human1.70750618
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.66506418
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.62896539
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62062262
32MYC_18940864_ChIP-ChIP_HL60_Human1.60488697
33E2F4_17652178_ChIP-ChIP_JURKAT_Human1.59183678
34IRF1_19129219_ChIP-ChIP_H3396_Human1.58331635
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58288820
36BCAT_22108803_ChIP-Seq_LS180_Human1.58211546
37TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57651506
38POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.57651506
39POU5F1_16153702_ChIP-ChIP_HESCs_Human1.56594655
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56071868
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53920823
42MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.53128037
43TP53_22573176_ChIP-Seq_HFKS_Human1.52251095
44CBP_20019798_ChIP-Seq_JUKART_Human1.51884874
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51884874
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.50166416
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.46812251
48VDR_23849224_ChIP-Seq_CD4+_Human1.46602513
49STAT3_23295773_ChIP-Seq_U87_Human1.42927777
50ELK1_19687146_ChIP-ChIP_HELA_Human1.40534498
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33963955
52RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33294020
53SMAD4_21799915_ChIP-Seq_A2780_Human1.31816677
54GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30961797
55TCF4_23295773_ChIP-Seq_U87_Human1.29459148
56AR_25329375_ChIP-Seq_VCAP_Human1.28155074
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27901830
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26530507
59TCF4_22108803_ChIP-Seq_LS180_Human1.25937610
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25700756
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.24165978
62SOX2_19829295_ChIP-Seq_ESCs_Human1.23758092
63NANOG_19829295_ChIP-Seq_ESCs_Human1.23758092
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22050209
65RUNX2_22187159_ChIP-Seq_PCA_Human1.19919072
66KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19155258
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17222717
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17022185
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16875070
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15736981
71FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15710317
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.15710317
73AR_21572438_ChIP-Seq_LNCaP_Human1.13551934
74ETS1_20019798_ChIP-Seq_JURKAT_Human1.10125077
75SMAD4_21741376_ChIP-Seq_EPCs_Human1.08761637
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.07839442
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.07823267
78HOXB7_26014856_ChIP-Seq_BT474_Human1.06815018
79NCOR_22424771_ChIP-Seq_293T_Human1.05890290
80* GATA3_21878914_ChIP-Seq_MCF-7_Human1.05623170
81FOXP3_21729870_ChIP-Seq_TREG_Human1.03635587
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01136178
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00510855
84BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99811357
85FLI1_21867929_ChIP-Seq_TH2_Mouse0.99378313
86FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98441747
87JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.97977058
88AR_20517297_ChIP-Seq_VCAP_Human0.97623109
89REST_21632747_ChIP-Seq_MESCs_Mouse0.97216979
90AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96547133
91RNF2_27304074_Chip-Seq_NSC_Mouse0.94955142
92PRDM14_20953172_ChIP-Seq_ESCs_Human0.94613850
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94470240
94OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93876547
95EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92932629
96CDX2_22108803_ChIP-Seq_LS180_Human0.92321427
97ETV2_25802403_ChIP-Seq_MESCs_Mouse0.89551331
98TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89502089
99MYC_19829295_ChIP-Seq_ESCs_Human0.88753414
100SRF_21415370_ChIP-Seq_HL-1_Mouse0.88198684

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.35470747
2MP0003136_yellow_coat_color3.27699928
3MP0005174_abnormal_tail_pigmentation2.94473964
4MP0001986_abnormal_taste_sensitivity2.86081881
5MP0008057_abnormal_DNA_replication2.78303398
6MP0001968_abnormal_touch/_nociception2.68243505
7MP0002102_abnormal_ear_morphology2.55439220
8MP0006292_abnormal_olfactory_placode2.44901657
9MP0008058_abnormal_DNA_repair2.43212314
10MP0005551_abnormal_eye_electrophysiolog2.28127067
11MP0002736_abnormal_nociception_after2.24127445
12MP0003195_calcinosis2.21864239
13MP0002638_abnormal_pupillary_reflex2.12601526
14MP0005171_absent_coat_pigmentation2.10386323
15MP0001188_hyperpigmentation2.09412204
16MP0003718_maternal_effect1.97267457
17MP0000569_abnormal_digit_pigmentation1.94058719
18MP0003787_abnormal_imprinting1.86895429
19MP0003890_abnormal_embryonic-extraembry1.86665693
20MP0010094_abnormal_chromosome_stability1.81886373
21MP0003646_muscle_fatigue1.79550761
22MP0004043_abnormal_pH_regulation1.76317389
23MP0006072_abnormal_retinal_apoptosis1.75193610
24MP0005423_abnormal_somatic_nervous1.70331550
25MP0002938_white_spotting1.67146369
26MP0005253_abnormal_eye_physiology1.64539134
27MP0004133_heterotaxia1.57901742
28MP0000427_abnormal_hair_cycle1.56453166
29MP0008872_abnormal_physiological_respon1.52539615
30MP0003693_abnormal_embryo_hatching1.47855975
31MP0003880_abnormal_central_pattern1.41386954
32MP0001485_abnormal_pinna_reflex1.39691553
33MP0002735_abnormal_chemical_nociception1.35460090
34MP0006276_abnormal_autonomic_nervous1.34883815
35MP0009745_abnormal_behavioral_response1.33216199
36MP0008875_abnormal_xenobiotic_pharmacok1.32222996
37MP0002837_dystrophic_cardiac_calcinosis1.31326891
38MP0004142_abnormal_muscle_tone1.29649364
39MP0000631_abnormal_neuroendocrine_gland1.28698699
40MP0003119_abnormal_digestive_system1.28418958
41MP0005646_abnormal_pituitary_gland1.25932106
42MP0002160_abnormal_reproductive_system1.22944928
43MP0001486_abnormal_startle_reflex1.20208140
44MP0000372_irregular_coat_pigmentation1.19641037
45MP0001293_anophthalmia1.19279142
46MP0002254_reproductive_system_inflammat1.17934655
47MP0009046_muscle_twitch1.17075357
48MP0002751_abnormal_autonomic_nervous1.15689365
49MP0004147_increased_porphyrin_level1.14844974
50MP0000538_abnormal_urinary_bladder1.14535437
51MP0002272_abnormal_nervous_system1.13855837
52MP0000015_abnormal_ear_pigmentation1.13766958
53MP0001984_abnormal_olfaction1.13759517
54MP0003011_delayed_dark_adaptation1.11696479
55MP0003121_genomic_imprinting1.10337459
56MP0001929_abnormal_gametogenesis1.06650447
57MP0010386_abnormal_urinary_bladder1.06185402
58MP0002210_abnormal_sex_determination1.01740930
59MP0008995_early_reproductive_senescence1.01198154
60MP0002095_abnormal_skin_pigmentation1.01024443
61MP0005084_abnormal_gallbladder_morpholo1.00900876
62MP0003111_abnormal_nucleus_morphology0.98675072
63MP0005410_abnormal_fertilization0.97968748
64MP0003937_abnormal_limbs/digits/tail_de0.97841204
65MP0005389_reproductive_system_phenotype0.96679038
66MP0003698_abnormal_male_reproductive0.95164216
67MP0004215_abnormal_myocardial_fiber0.93860538
68MP0004885_abnormal_endolymph0.93824200
69MP0008789_abnormal_olfactory_epithelium0.91387936
70MP0003567_abnormal_fetal_cardiomyocyte0.90654235
71MP0001324_abnormal_eye_pigmentation0.90137970
72MP0000383_abnormal_hair_follicle0.89633893
73MP0000653_abnormal_sex_gland0.89136791
74MP0005386_behavior/neurological_phenoty0.88775463
75MP0004924_abnormal_behavior0.88775463
76MP0002557_abnormal_social/conspecific_i0.88630027
77MP0002653_abnormal_ependyma_morphology0.88106345
78MP0003786_premature_aging0.87400576
79MP0001501_abnormal_sleep_pattern0.86586448
80MP0004145_abnormal_muscle_electrophysio0.86519514
81MP0002067_abnormal_sensory_capabilities0.85613259
82MP0002572_abnormal_emotion/affect_behav0.85517048
83MP0005395_other_phenotype0.85328428
84MP0001529_abnormal_vocalization0.85188774
85MP0001919_abnormal_reproductive_system0.85134755
86MP0001970_abnormal_pain_threshold0.84786718
87MP0001145_abnormal_male_reproductive0.84361998
88MP0005195_abnormal_posterior_eye0.83960674
89MP0003137_abnormal_impulse_conducting0.81557989
90MP0001756_abnormal_urination0.81546269
91MP0005645_abnormal_hypothalamus_physiol0.81062441
92MP0000647_abnormal_sebaceous_gland0.80218327
93MP0002928_abnormal_bile_duct0.79916174
94MP0005075_abnormal_melanosome_morpholog0.76925951
95MP0003077_abnormal_cell_cycle0.76828043
96MP0000778_abnormal_nervous_system0.76543601
97MP0001119_abnormal_female_reproductive0.75358529
98MP0002234_abnormal_pharynx_morphology0.75344763
99MP0002064_seizures0.75337382
100MP0001502_abnormal_circadian_rhythm0.74417698

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.14731115
2Pancreatic cysts (HP:0001737)3.94330266
3Abnormality of midbrain morphology (HP:0002418)3.68825539
4Molar tooth sign on MRI (HP:0002419)3.68825539
5Pancreatic fibrosis (HP:0100732)3.50920001
6Attenuation of retinal blood vessels (HP:0007843)3.47475338
7True hermaphroditism (HP:0010459)3.40316635
8Nephronophthisis (HP:0000090)3.36179938
9Chronic hepatic failure (HP:0100626)3.05529764
10Colon cancer (HP:0003003)2.92558511
11Abnormality of the renal medulla (HP:0100957)2.88302022
12Patellar aplasia (HP:0006443)2.76843493
13Birth length less than 3rd percentile (HP:0003561)2.69589887
14Abnormality of the labia minora (HP:0012880)2.69403641
15Pendular nystagmus (HP:0012043)2.56378843
16Hyperventilation (HP:0002883)2.55474937
17Abnormality of the pons (HP:0007361)2.53623177
18Hypoplasia of the pons (HP:0012110)2.52128868
19Aplasia/Hypoplasia of the patella (HP:0006498)2.51691012
20Rib fusion (HP:0000902)2.50435143
21Medial flaring of the eyebrow (HP:0010747)2.49079058
22Gaze-evoked nystagmus (HP:0000640)2.48353654
23Abnormality of alanine metabolism (HP:0010916)2.46210746
24Hyperalaninemia (HP:0003348)2.46210746
25Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.46210746
26Cystic liver disease (HP:0006706)2.40077597
27Abnormal biliary tract physiology (HP:0012439)2.38141811
28Bile duct proliferation (HP:0001408)2.38141811
29Aplasia/Hypoplasia of the uvula (HP:0010293)2.37340345
30Abnormality of the renal cortex (HP:0011035)2.32835667
31Decreased central vision (HP:0007663)2.31563700
32Protruding tongue (HP:0010808)2.30680256
33Tubular atrophy (HP:0000092)2.30575897
34Abolished electroretinogram (ERG) (HP:0000550)2.30120108
35Decreased electroretinogram (ERG) amplitude (HP:0000654)2.28817272
36Bony spicule pigmentary retinopathy (HP:0007737)2.27928783
37Chorioretinal atrophy (HP:0000533)2.27703205
38Abnormal drinking behavior (HP:0030082)2.23770045
39Polydipsia (HP:0001959)2.23770045
40Absent thumb (HP:0009777)2.22774982
41Genetic anticipation (HP:0003743)2.20941272
42Meckel diverticulum (HP:0002245)2.20433647
43Abnormality of the ileum (HP:0001549)2.20128322
44Small hand (HP:0200055)2.14159871
45Broad-based gait (HP:0002136)2.13595387
46Chromosomal breakage induced by crosslinking agents (HP:0003221)2.12846390
47Progressive inability to walk (HP:0002505)2.04821019
48Sloping forehead (HP:0000340)2.04022457
49Anencephaly (HP:0002323)2.03294498
50Abnormality of chromosome stability (HP:0003220)2.02875533
51Methylmalonic acidemia (HP:0002912)2.02723702
52Inability to walk (HP:0002540)2.02244547
53Chromsome breakage (HP:0040012)2.02173208
54Aplasia/Hypoplasia of the tongue (HP:0010295)2.00483878
55Absent radius (HP:0003974)1.99722963
56Clubbing of toes (HP:0100760)1.98069734
57Type II lissencephaly (HP:0007260)1.97414506
58Congenital hepatic fibrosis (HP:0002612)1.96480644
59Aplasia involving forearm bones (HP:0009822)1.95173754
60Absent forearm bone (HP:0003953)1.95173754
61Male pseudohermaphroditism (HP:0000037)1.92752469
62Decreased circulating renin level (HP:0003351)1.92472063
63Aplasia/Hypoplasia of the tibia (HP:0005772)1.91474259
64Methylmalonic aciduria (HP:0012120)1.91458180
65Stomach cancer (HP:0012126)1.90345347
66Progressive cerebellar ataxia (HP:0002073)1.89892100
67Rectal fistula (HP:0100590)1.89275061
68Rectovaginal fistula (HP:0000143)1.89275061
69Intestinal atresia (HP:0011100)1.88850324
70Ectopic kidney (HP:0000086)1.88548112
71Sclerocornea (HP:0000647)1.87772848
72Duplicated collecting system (HP:0000081)1.86660346
73Gait imbalance (HP:0002141)1.85959210
74Genital tract atresia (HP:0001827)1.83886403
75Aplasia/Hypoplasia involving the musculature (HP:0001460)1.83253593
76Congenital primary aphakia (HP:0007707)1.82696735
77Neoplasm of the adrenal cortex (HP:0100641)1.82645466
78Dandy-Walker malformation (HP:0001305)1.82412962
79Abnormality of the renal collecting system (HP:0004742)1.82205490
80Clumsiness (HP:0002312)1.81964155
81Polyuria (HP:0000103)1.80571025
82Hyperglycinuria (HP:0003108)1.79770850
83Vaginal atresia (HP:0000148)1.77870283
84Hypoalbuminemia (HP:0003073)1.77540946
85Abnormal albumin level (HP:0012116)1.77540946
86Fair hair (HP:0002286)1.76397513
87Facial diplegia (HP:0001349)1.76271292
88Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73909456
89Increased CSF lactate (HP:0002490)1.73840166
90Nephrogenic diabetes insipidus (HP:0009806)1.73621757
91Lissencephaly (HP:0001339)1.72004692
92Optic nerve hypoplasia (HP:0000609)1.71953401
93Cerebellar dysplasia (HP:0007033)1.71779473
94Intestinal fistula (HP:0100819)1.71293721
95Septo-optic dysplasia (HP:0100842)1.69555484
96Absent speech (HP:0001344)1.69138940
97Preaxial hand polydactyly (HP:0001177)1.67589354
98Lipid accumulation in hepatocytes (HP:0006561)1.66973493
99Abnormal rod and cone electroretinograms (HP:0008323)1.65792463
100Abnormality of the preputium (HP:0100587)1.65657932

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.38477344
2BMPR1B3.59317814
3ACVR1B3.39391636
4ZAK3.06726772
5NUAK12.86766185
6WNK32.76730736
7MKNK22.70316889
8TNIK2.36936809
9ADRBK22.23140636
10TLK12.17564679
11MAP4K22.05662160
12INSRR2.02643852
13GRK11.99306581
14WNK41.95452616
15CASK1.74462564
16MAPK151.68228328
17OXSR11.58027614
18BRSK21.56552202
19AKT31.50479185
20TRIM281.48302358
21MKNK11.46599917
22MAPK131.46227103
23CDC71.40617478
24TGFBR11.35889893
25MAP3K41.28675962
26VRK11.23051412
27STK391.17177195
28PLK31.14215491
29PNCK1.13816650
30PLK41.11886374
31MUSK1.10504604
32VRK21.06345470
33TAF11.03868441
34MST40.99225577
35BUB10.97587526
36NLK0.96152133
37FGFR20.95615805
38ADRBK10.95581812
39TAOK30.93175724
40DYRK20.93110146
41PINK10.92246804
42WEE10.90900654
43STK160.86406719
44TTK0.85853844
45DAPK20.84572507
46ATR0.84195339
47STK38L0.82903080
48PLK10.82338708
49PAK30.81839384
50SRPK10.80880723
51CAMK1D0.79170086
52TSSK60.74972976
53CAMK1G0.72893883
54PLK20.72694694
55PRKCG0.71992731
56CSNK1G10.71535134
57PRKCE0.68195017
58CHEK20.65704023
59TIE10.63123834
60NME10.62327022
61TEC0.60890740
62MARK10.60569504
63EIF2AK30.60365696
64CAMKK20.58987885
65BRD40.57943812
66NEK20.56909092
67ATM0.56442811
68MELK0.56309427
69TXK0.55302854
70PDK20.54539766
71MAP2K60.53410616
72STK30.53075774
73CSNK1G20.52714226
74PBK0.50998005
75RPS6KA50.50773487
76CSNK1A1L0.50334839
77CAMK10.48175724
78EPHA40.47390127
79SGK20.47150116
80STK110.46990605
81OBSCN0.45183874
82PIK3CA0.44276322
83CSNK1D0.42619017
84CSNK1G30.42576718
85PKN10.40574189
86CHUK0.37474287
87PRKAA10.37130250
88PRKAA20.36377950
89FLT30.35991682
90TNK20.35880689
91DYRK1A0.35773162
92MAP2K70.34792386
93DYRK30.34690836
94IKBKB0.32590832
95MAPKAPK50.32081092
96PRKACA0.31349942
97PRKCI0.31127802
98PRKCQ0.29256831
99SGK4940.29127628
100SGK2230.29127628

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034602.78069631
2Homologous recombination_Homo sapiens_hsa034402.76931273
3RNA polymerase_Homo sapiens_hsa030202.69707227
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.68966658
5Phototransduction_Homo sapiens_hsa047442.30407247
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.29072429
7Non-homologous end-joining_Homo sapiens_hsa034502.19900913
8Basal transcription factors_Homo sapiens_hsa030222.16155551
9Nitrogen metabolism_Homo sapiens_hsa009102.02223704
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.99632056
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.98449060
12Selenocompound metabolism_Homo sapiens_hsa004501.98392798
13Linoleic acid metabolism_Homo sapiens_hsa005911.96924054
14Nicotine addiction_Homo sapiens_hsa050331.93288683
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.85580408
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.84605646
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.83815083
18Butanoate metabolism_Homo sapiens_hsa006501.76223474
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.75808544
20RNA degradation_Homo sapiens_hsa030181.75579718
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.66165715
22Taste transduction_Homo sapiens_hsa047421.61723320
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.60522337
24Propanoate metabolism_Homo sapiens_hsa006401.57320821
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.54904397
26Oxidative phosphorylation_Homo sapiens_hsa001901.54459096
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.49515026
28Tryptophan metabolism_Homo sapiens_hsa003801.46263751
29Caffeine metabolism_Homo sapiens_hsa002321.44170810
30Protein export_Homo sapiens_hsa030601.43976410
31Mismatch repair_Homo sapiens_hsa034301.40591178
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.32316106
33Ether lipid metabolism_Homo sapiens_hsa005651.32181240
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.31039783
35One carbon pool by folate_Homo sapiens_hsa006701.28609968
36Parkinsons disease_Homo sapiens_hsa050121.22603398
37Proteasome_Homo sapiens_hsa030501.17246674
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.07305023
39Lysine degradation_Homo sapiens_hsa003101.07188815
40Huntingtons disease_Homo sapiens_hsa050161.06667338
41Vitamin digestion and absorption_Homo sapiens_hsa049771.06403199
42Base excision repair_Homo sapiens_hsa034101.05935609
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04347904
44Olfactory transduction_Homo sapiens_hsa047401.03872281
45Sulfur relay system_Homo sapiens_hsa041221.03639316
46RNA transport_Homo sapiens_hsa030131.02767694
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.01090286
48Peroxisome_Homo sapiens_hsa041461.00593401
49Chemical carcinogenesis_Homo sapiens_hsa052040.99841164
50Purine metabolism_Homo sapiens_hsa002300.98816801
51Nucleotide excision repair_Homo sapiens_hsa034200.96956294
52ABC transporters_Homo sapiens_hsa020100.95901855
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94361534
54Circadian rhythm_Homo sapiens_hsa047100.92184302
55Retinol metabolism_Homo sapiens_hsa008300.89723706
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87707551
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.85936032
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85926292
59beta-Alanine metabolism_Homo sapiens_hsa004100.83126943
60Pyrimidine metabolism_Homo sapiens_hsa002400.81787262
61Ovarian steroidogenesis_Homo sapiens_hsa049130.79372558
62Hedgehog signaling pathway_Homo sapiens_hsa043400.76702823
63Morphine addiction_Homo sapiens_hsa050320.75710684
64DNA replication_Homo sapiens_hsa030300.75604216
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70954123
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69486585
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66565833
68Steroid biosynthesis_Homo sapiens_hsa001000.66376183
69Arachidonic acid metabolism_Homo sapiens_hsa005900.64663111
70Calcium signaling pathway_Homo sapiens_hsa040200.64566827
71Alzheimers disease_Homo sapiens_hsa050100.63634996
72Cell cycle_Homo sapiens_hsa041100.63412896
73Glutamatergic synapse_Homo sapiens_hsa047240.63285068
74Serotonergic synapse_Homo sapiens_hsa047260.63178132
75Metabolic pathways_Homo sapiens_hsa011000.61789706
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61327648
77Histidine metabolism_Homo sapiens_hsa003400.59703610
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.57960045
79Basal cell carcinoma_Homo sapiens_hsa052170.57781963
80Insulin secretion_Homo sapiens_hsa049110.57238966
81p53 signaling pathway_Homo sapiens_hsa041150.53770405
82Regulation of autophagy_Homo sapiens_hsa041400.53598861
83Glycerolipid metabolism_Homo sapiens_hsa005610.53587701
84Circadian entrainment_Homo sapiens_hsa047130.51874097
85Cardiac muscle contraction_Homo sapiens_hsa042600.51792501
86Fatty acid degradation_Homo sapiens_hsa000710.50745773
87Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.49829559
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48100098
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48041454
90Fat digestion and absorption_Homo sapiens_hsa049750.47681774
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47634144
92GABAergic synapse_Homo sapiens_hsa047270.46982343
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45896419
94TGF-beta signaling pathway_Homo sapiens_hsa043500.45524290
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44539636
96Pyruvate metabolism_Homo sapiens_hsa006200.43568316
97Mineral absorption_Homo sapiens_hsa049780.35327085
98Hippo signaling pathway_Homo sapiens_hsa043900.34035615
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33331130
100mRNA surveillance pathway_Homo sapiens_hsa030150.32530944

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