ZNF816-ZNF321P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents naturally occurring read-through transcription between the zinc finger protein 816 (ZNF816) gene and the zinc finger protein 321 (ZNF321) pseudogene on chromosome 19. The read-through transcript encodes a KRAB domain-containing protein that shares sequence identity with the upstream gene product, but it contains a distinct C-terminus encoded by exon structure from the downstream pseudogene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)4.69286624
2DNA double-strand break processing (GO:0000729)3.99065480
3ribosome assembly (GO:0042255)3.93007577
4indole-containing compound catabolic process (GO:0042436)3.81130129
5indolalkylamine catabolic process (GO:0046218)3.81130129
6tryptophan catabolic process (GO:0006569)3.81130129
7termination of RNA polymerase III transcription (GO:0006386)3.75704140
8transcription elongation from RNA polymerase III promoter (GO:0006385)3.75704140
9ribosomal large subunit biogenesis (GO:0042273)3.75019717
10DNA deamination (GO:0045006)3.71501314
11oxidative phosphorylation (GO:0006119)3.69875544
12rRNA modification (GO:0000154)3.65758622
13kynurenine metabolic process (GO:0070189)3.61747027
14tryptophan metabolic process (GO:0006568)3.58221489
15protein neddylation (GO:0045116)3.50872127
16negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.49093901
17nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.48290049
18indolalkylamine metabolic process (GO:0006586)3.44493152
19exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.44478802
20transcription from mitochondrial promoter (GO:0006390)3.43017096
21positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.41589338
22regulation of cellular amino acid metabolic process (GO:0006521)3.40214507
23cytochrome complex assembly (GO:0017004)3.38894808
24protein complex biogenesis (GO:0070271)3.38254473
25metallo-sulfur cluster assembly (GO:0031163)3.35183328
26iron-sulfur cluster assembly (GO:0016226)3.35183328
27signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.32313980
28signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.32313980
29signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.32313980
30replication fork processing (GO:0031297)3.31505409
31cullin deneddylation (GO:0010388)3.28494591
32mitochondrial respiratory chain complex assembly (GO:0033108)3.26242679
33DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.25916287
34mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.25055601
35CENP-A containing nucleosome assembly (GO:0034080)3.24543008
36regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.23963812
37establishment of protein localization to mitochondrial membrane (GO:0090151)3.22945777
38respiratory chain complex IV assembly (GO:0008535)3.22355186
39signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.19229274
40intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.19229274
41purine nucleobase biosynthetic process (GO:0009113)3.18454597
42signal transduction involved in DNA integrity checkpoint (GO:0072401)3.17803810
43signal transduction involved in DNA damage checkpoint (GO:0072422)3.17803810
44neutrophil activation involved in immune response (GO:0002283)3.13562064
45pseudouridine synthesis (GO:0001522)3.13528810
46branched-chain amino acid catabolic process (GO:0009083)3.12625677
47chromatin remodeling at centromere (GO:0031055)3.12622721
48protein deneddylation (GO:0000338)3.11020577
49signal transduction involved in cell cycle checkpoint (GO:0072395)3.10965975
50negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.10960981
51negative regulation of ligase activity (GO:0051352)3.10960981
52DNA catabolic process, exonucleolytic (GO:0000738)3.09988128
53ribosomal small subunit assembly (GO:0000028)3.05673455
54nucleobase biosynthetic process (GO:0046112)3.05458072
55mitochondrial respiratory chain complex I assembly (GO:0032981)3.05240508
56NADH dehydrogenase complex assembly (GO:0010257)3.05240508
57mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.05240508
58energy coupled proton transport, down electrochemical gradient (GO:0015985)3.02278396
59ATP synthesis coupled proton transport (GO:0015986)3.02278396
60ether lipid metabolic process (GO:0046485)3.00345465
61regulation of mitotic spindle checkpoint (GO:1903504)2.97089283
62regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.97089283
63ADP metabolic process (GO:0046031)2.95527397
64rRNA methylation (GO:0031167)2.95515797
65somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.93973562
66somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.93973562
67isotype switching (GO:0045190)2.93973562
68anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.93373799
69positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.93279443
70maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.91560953
71histone exchange (GO:0043486)2.91434136
72mitochondrial RNA metabolic process (GO:0000959)2.91264281
73glycerol ether metabolic process (GO:0006662)2.90654472
74purine nucleotide salvage (GO:0032261)2.88516815
75response to interferon-beta (GO:0035456)2.87100436
76mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.86905824
77pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.86656400
78pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.86586069
79pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.86169812
80UMP biosynthetic process (GO:0006222)2.86169812
81pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.86169812
82UMP metabolic process (GO:0046049)2.86169812
83ubiquinone biosynthetic process (GO:0006744)2.83757571
84base-excision repair, AP site formation (GO:0006285)2.83430608
85DNA damage response, detection of DNA damage (GO:0042769)2.82275060
86positive regulation of ligase activity (GO:0051351)2.81813584
87non-recombinational repair (GO:0000726)2.80660881
88double-strand break repair via nonhomologous end joining (GO:0006303)2.80660881
89purine deoxyribonucleotide catabolic process (GO:0009155)2.80345579
90aromatic amino acid family catabolic process (GO:0009074)2.76941685
91synapsis (GO:0007129)2.75547827
92DNA replication checkpoint (GO:0000076)2.73675417
93preassembly of GPI anchor in ER membrane (GO:0016254)2.72555645
94establishment of integrated proviral latency (GO:0075713)2.71209301
95ether metabolic process (GO:0018904)2.66671305
96aggressive behavior (GO:0002118)2.62967868
97RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.60664997
98antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.56959198
99negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.56454275
100hepatocyte differentiation (GO:0070365)2.55567085

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.72916957
2E2F7_22180533_ChIP-Seq_HELA_Human4.25938292
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.17763469
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.89936596
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.54867282
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.40184801
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.09125542
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.08327608
9VDR_23849224_ChIP-Seq_CD4+_Human2.74086151
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.71620575
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.67338443
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.64800717
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.61786340
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.61203328
15SRF_21415370_ChIP-Seq_HL-1_Mouse2.52226708
16FOXP3_21729870_ChIP-Seq_TREG_Human2.45179094
17ELK1_19687146_ChIP-ChIP_HELA_Human2.44133844
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.43231482
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.35818283
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.30036792
21CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.28390088
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.22535875
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.10426264
24VDR_22108803_ChIP-Seq_LS180_Human2.01474759
25HOXB4_20404135_ChIP-ChIP_EML_Mouse1.99631253
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.96371125
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.92177890
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91816846
29FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.85869499
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.85355915
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.83263495
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.80608282
33ZNF274_21170338_ChIP-Seq_K562_Hela1.70818038
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.68645667
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.67516410
36DCP1A_22483619_ChIP-Seq_HELA_Human1.65732235
37PADI4_21655091_ChIP-ChIP_MCF-7_Human1.64151750
38MYC_18940864_ChIP-ChIP_HL60_Human1.60731203
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60372596
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60045514
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.59930723
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.54105089
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.51663742
44IRF8_22096565_ChIP-ChIP_GC-B_Human1.43461211
45TTF2_22483619_ChIP-Seq_HELA_Human1.35695572
46GABP_19822575_ChIP-Seq_HepG2_Human1.35371445
47CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.33763879
48LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.31336140
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.28496722
50MYB_26560356_Chip-Seq_TH2_Human1.28241527
51SPI1_23547873_ChIP-Seq_NB4_Human1.26958491
52EWS_26573619_Chip-Seq_HEK293_Human1.24409053
53FUS_26573619_Chip-Seq_HEK293_Human1.22051304
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20867223
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.20502356
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.19804963
57GATA3_26560356_Chip-Seq_TH2_Human1.17488578
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.17038671
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16622866
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.16464719
61ELK1_22589737_ChIP-Seq_MCF10A_Human1.12106538
62IRF8_21731497_ChIP-ChIP_J774_Mouse1.11211392
63FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11044024
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10902607
65FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08525571
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08120642
67FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.07723241
68AR_20517297_ChIP-Seq_VCAP_Human1.06859095
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.05499265
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05499265
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05430707
72ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02051907
73CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99075855
74HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98692790
75FOXM1_23109430_ChIP-Seq_U2OS_Human0.98157124
76BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97930235
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96702733
78SALL4_22934838_ChIP-ChIP_CD34+_Human0.95600650
79MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.93917175
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.90737370
81TP53_22573176_ChIP-Seq_HFKS_Human0.89994734
82KDM5A_27292631_Chip-Seq_BREAST_Human0.87921081
83EGR1_23403033_ChIP-Seq_LIVER_Mouse0.87179034
84CBP_20019798_ChIP-Seq_JUKART_Human0.87136387
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87136387
86POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.85468781
87PCGF2_27294783_Chip-Seq_ESCs_Mouse0.84816143
88CDX2_22108803_ChIP-Seq_LS180_Human0.84047273
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.83595840
90LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.82434464
91TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.81178054
92E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.79575161
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.77435331
94HTT_18923047_ChIP-ChIP_STHdh_Human0.77216381
95ELF5_23300383_ChIP-Seq_T47D_Human0.75103864
96SCL_19346495_ChIP-Seq_HPC-7_Human0.74524583
97MYCN_18555785_ChIP-Seq_MESCs_Mouse0.73810970
98GATA1_22025678_ChIP-Seq_K562_Human0.73569502
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.72489823
100STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.71982710

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.64628621
2MP0003195_calcinosis3.23060356
3MP0008058_abnormal_DNA_repair3.15573948
4MP0010094_abnormal_chromosome_stability3.03199872
5MP0005646_abnormal_pituitary_gland2.88195365
6MP0006072_abnormal_retinal_apoptosis2.61446763
7MP0000516_abnormal_urinary_system2.50220760
8MP0005367_renal/urinary_system_phenotyp2.50220760
9MP0003186_abnormal_redox_activity2.48491036
10MP0006292_abnormal_olfactory_placode2.47494342
11MP0008875_abnormal_xenobiotic_pharmacok2.32261863
12MP0001835_abnormal_antigen_presentation2.32134263
13MP0002163_abnormal_gland_morphology2.24508567
14MP0005084_abnormal_gallbladder_morpholo2.16207995
15MP0001853_heart_inflammation2.13719829
16MP0006036_abnormal_mitochondrial_physio2.04441581
17MP0009697_abnormal_copulation1.99284877
18MP0006054_spinal_hemorrhage1.93469641
19MP0009764_decreased_sensitivity_to1.90672537
20MP0003786_premature_aging1.87793181
21MP0003718_maternal_effect1.86744370
22MP0004957_abnormal_blastocyst_morpholog1.85222881
23MP0008995_early_reproductive_senescence1.81384062
24MP0002148_abnormal_hypersensitivity_rea1.80178764
25MP0008775_abnormal_heart_ventricle1.79510622
26MP0002822_catalepsy1.79258948
27MP0002736_abnormal_nociception_after1.76752757
28MP0005671_abnormal_response_to1.76372447
29MP0001188_hyperpigmentation1.75711749
30MP0010368_abnormal_lymphatic_system1.74093298
31MP0000372_irregular_coat_pigmentation1.73626538
32MP0005410_abnormal_fertilization1.70575243
33MP0003763_abnormal_thymus_physiology1.65707665
34MP0005464_abnormal_platelet_physiology1.64943321
35MP0009379_abnormal_foot_pigmentation1.60718794
36MP0003252_abnormal_bile_duct1.54299578
37MP0003693_abnormal_embryo_hatching1.51268163
38MP0008057_abnormal_DNA_replication1.46697967
39MP0008872_abnormal_physiological_respon1.45893948
40MP0006035_abnormal_mitochondrial_morpho1.44007420
41MP0004147_increased_porphyrin_level1.43946014
42MP0005379_endocrine/exocrine_gland_phen1.38579002
43MP0001764_abnormal_homeostasis1.37330076
44MP0005075_abnormal_melanosome_morpholog1.33370078
45MP0005636_abnormal_mineral_homeostasis1.28046178
46MP0002138_abnormal_hepatobiliary_system1.26694344
47MP0005253_abnormal_eye_physiology1.22107678
48MP0001968_abnormal_touch/_nociception1.21552253
49MP0003077_abnormal_cell_cycle1.21410897
50MP0002837_dystrophic_cardiac_calcinosis1.20486541
51MP0003011_delayed_dark_adaptation1.20136461
52MP0001800_abnormal_humoral_immune1.18078812
53MP0002166_altered_tumor_susceptibility1.16341455
54MP0008004_abnormal_stomach_pH1.13660567
55MP0002452_abnormal_antigen_presenting1.09730482
56MP0003111_abnormal_nucleus_morphology1.08387703
57MP0010155_abnormal_intestine_physiology1.06419913
58MP0008932_abnormal_embryonic_tissue1.06187431
59MP0001529_abnormal_vocalization1.05027090
60MP0003315_abnormal_perineum_morphology1.04967506
61MP0002019_abnormal_tumor_incidence1.04235385
62MP0002006_tumorigenesis1.04166229
63MP0008007_abnormal_cellular_replicative1.03243251
64MP0005332_abnormal_amino_acid1.01012828
65MP0005389_reproductive_system_phenotype1.00430046
66MP0000689_abnormal_spleen_morphology0.99627264
67MP0009785_altered_susceptibility_to0.98544108
68MP0000465_gastrointestinal_hemorrhage0.98498633
69MP0002938_white_spotting0.97670364
70MP0001545_abnormal_hematopoietic_system0.97499703
71MP0005397_hematopoietic_system_phenotyp0.97499703
72MP0000685_abnormal_immune_system0.97431313
73MP0002398_abnormal_bone_marrow0.96735213
74MP0001919_abnormal_reproductive_system0.96570487
75MP0002132_abnormal_respiratory_system0.93550640
76MP0005000_abnormal_immune_tolerance0.91763015
77MP0002723_abnormal_immune_serum0.91711049
78MP0002420_abnormal_adaptive_immunity0.91256879
79MP0001819_abnormal_immune_cell0.91154636
80MP0000358_abnormal_cell_content/0.91064622
81MP0001905_abnormal_dopamine_level0.89931008
82MP0005395_other_phenotype0.89354465
83MP0003724_increased_susceptibility_to0.87730535
84MP0002396_abnormal_hematopoietic_system0.86734757
85MP0005165_increased_susceptibility_to0.86346991
86MP0002722_abnormal_immune_system0.85593986
87MP0002160_abnormal_reproductive_system0.77686825
88MP0004808_abnormal_hematopoietic_stem0.76761987
89MP0001879_abnormal_lymphatic_vessel0.76067412
90MP0004264_abnormal_extraembryonic_tissu0.75256335
91MP0000716_abnormal_immune_system0.75027910
92MP0002429_abnormal_blood_cell0.75011530
93MP0000703_abnormal_thymus_morphology0.74958952
94MP0009765_abnormal_xenobiotic_induced0.74788227
95MP0001293_anophthalmia0.73084957
96MP0006082_CNS_inflammation0.72777784
97MP0005584_abnormal_enzyme/coenzyme_acti0.72302795
98MP0001845_abnormal_inflammatory_respons0.70609609
99MP0005551_abnormal_eye_electrophysiolog0.70024052
100MP0002419_abnormal_innate_immunity0.69597056

Predicted human phenotypes

RankGene SetZ-score
1Hepatocellular necrosis (HP:0001404)3.41040140
2Hepatic necrosis (HP:0002605)3.34116733
33-Methylglutaconic aciduria (HP:0003535)3.30880604
4Prostate neoplasm (HP:0100787)3.22324572
5Abnormality of the prostate (HP:0008775)3.17316042
6Acute necrotizing encephalopathy (HP:0006965)3.17078073
7Mitochondrial inheritance (HP:0001427)2.98110339
8Abnormal mitochondria in muscle tissue (HP:0008316)2.97455349
9Panhypogammaglobulinemia (HP:0003139)2.96893735
10Increased CSF lactate (HP:0002490)2.94039626
11Increased serum lactate (HP:0002151)2.73554395
12Acute hepatic failure (HP:0006554)2.68197864
13Progressive macrocephaly (HP:0004481)2.66896985
14Acute encephalopathy (HP:0006846)2.66373898
15Methylmalonic acidemia (HP:0002912)2.57308138
16Methylmalonic aciduria (HP:0012120)2.56428761
17Elevated erythrocyte sedimentation rate (HP:0003565)2.56206500
18Ketoacidosis (HP:0001993)2.55774549
19Decreased activity of mitochondrial respiratory chain (HP:0008972)2.55087290
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.55087290
21Lactic acidosis (HP:0003128)2.54655694
22Amaurosis fugax (HP:0100576)2.51268771
23Hypoplasia of the uterus (HP:0000013)2.48863370
24Cerebral edema (HP:0002181)2.46137701
25Exertional dyspnea (HP:0002875)2.43312059
26Aplasia/hypoplasia of the uterus (HP:0008684)2.43112432
27Reduced antithrombin III activity (HP:0001976)2.39040414
28Pendular nystagmus (HP:0012043)2.38315289
29Tinnitus (HP:0000360)2.35998150
30Abnormality of macular pigmentation (HP:0008002)2.34772180
31Congenital, generalized hypertrichosis (HP:0004540)2.32197545
32Lethargy (HP:0001254)2.28315118
33Petechiae (HP:0000967)2.26125408
34Abnormal protein glycosylation (HP:0012346)2.24401407
35Abnormal glycosylation (HP:0012345)2.24401407
36Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.24401407
37Abnormal protein N-linked glycosylation (HP:0012347)2.24401407
38Myelodysplasia (HP:0002863)2.24113361
39Type I transferrin isoform profile (HP:0003642)2.23624276
40Abnormality of methionine metabolism (HP:0010901)2.22187408
41Absent thumb (HP:0009777)2.20724391
42Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.18552271
43Abnormality of alanine metabolism (HP:0010916)2.18552271
44Hyperalaninemia (HP:0003348)2.18552271
45Fatigue (HP:0012378)2.17906148
46Abnormality of dicarboxylic acid metabolism (HP:0010995)2.17282268
47Dicarboxylic aciduria (HP:0003215)2.17282268
48Stomach cancer (HP:0012126)2.15247764
49Palpitations (HP:0001962)2.12842378
50Testicular atrophy (HP:0000029)2.12512355
51Stomatitis (HP:0010280)2.11848153
52Respiratory failure (HP:0002878)2.11209583
53Abnormal spermatogenesis (HP:0008669)2.08265623
54Abnormality of the preputium (HP:0100587)2.06967839
55Pancytopenia (HP:0001876)2.06260095
56Cerebral hemorrhage (HP:0001342)2.06159538
57Ketosis (HP:0001946)2.05502516
58Abnormality of the hepatic vasculature (HP:0006707)2.04606595
59Severe combined immunodeficiency (HP:0004430)2.02773357
60Gastrointestinal infarctions (HP:0005244)2.02288830
61Pancreatic cysts (HP:0001737)2.02036349
62Aplasia/Hypoplasia of the fovea (HP:0008060)2.01325089
63Hypoplasia of the fovea (HP:0007750)2.01325089
64Abnormality of male internal genitalia (HP:0000022)2.01040658
65Aplasia/Hypoplasia involving the musculature (HP:0001460)2.00179841
66Abnormality of homocysteine metabolism (HP:0010919)1.99804295
67Homocystinuria (HP:0002156)1.99804295
68Abnormality of pyrimidine metabolism (HP:0004353)1.99190596
69Abnormality of aspartate family amino acid metabolism (HP:0010899)1.98546343
70Hyperinsulinemic hypoglycemia (HP:0000825)1.97690740
71Aplasia/Hypoplasia of the uvula (HP:0010293)1.97651911
72Meckel diverticulum (HP:0002245)1.96612517
73Delayed CNS myelination (HP:0002188)1.96127435
74Carpal bone hypoplasia (HP:0001498)1.95193252
75Stenosis of the external auditory canal (HP:0000402)1.95015990
76Abolished electroretinogram (ERG) (HP:0000550)1.94340096
77Hyperglycinuria (HP:0003108)1.94178856
78Abnormality of the vitamin B12 metabolism (HP:0004341)1.90022968
79Myocardial infarction (HP:0001658)1.87803158
80IgG deficiency (HP:0004315)1.87308279
81Aplastic anemia (HP:0001915)1.86022131
82Gonadal dysgenesis (HP:0000133)1.85444854
83Hypoproteinemia (HP:0003075)1.83517909
84Abnormality of the ileum (HP:0001549)1.83438401
85Thrombocytosis (HP:0001894)1.83438357
86Abnormality of the fovea (HP:0000493)1.82292419
87Abnormality of vitamin B metabolism (HP:0004340)1.79029187
88Abnormality of T cell physiology (HP:0011840)1.78587356
89Posterior subcapsular cataract (HP:0007787)1.78481150
90Abnormality of B cell number (HP:0010975)1.78285329
91Optic disc pallor (HP:0000543)1.76639074
92Multiple enchondromatosis (HP:0005701)1.76629558
93Abnormality of serum amino acid levels (HP:0003112)1.73386186
94Abnormality of the heme biosynthetic pathway (HP:0010472)1.72797413
95True hermaphroditism (HP:0010459)1.69564008
96Abnormality of T cells (HP:0002843)1.67396087
97Symptomatic seizures (HP:0011145)1.67369242
98Renal Fanconi syndrome (HP:0001994)1.66902861
99CNS demyelination (HP:0007305)1.66332836
100Encephalitis (HP:0002383)1.65841700

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.82860716
2MST43.44682660
3VRK23.33846685
4EIF2AK33.09557978
5TIE13.03417734
6MAP4K22.73555406
7PBK2.55346820
8MAP3K122.27390299
9TEC2.21322034
10NUAK12.18773035
11MKNK12.18305856
12TAOK32.10548758
13BCKDK2.00357604
14MKNK21.90477702
15CDK191.89622841
16MUSK1.82938565
17TXK1.72863500
18SCYL21.68216881
19FRK1.66857210
20PLK41.63759868
21WNK31.63743094
22SRPK11.61831135
23PINK11.54554232
24EIF2AK11.52994398
25PLK31.46687564
26TLK11.44320520
27FLT31.36369235
28STK31.33827586
29BMPR21.31461731
30TTK1.29921736
31STK161.29624245
32OXSR11.28799906
33NME21.25768984
34TRIM281.21561674
35EIF2AK21.21081568
36ADRBK21.19906096
37MAP4K11.15445499
38GRK61.14543615
39BTK1.11643752
40TSSK61.09139534
41VRK11.06784407
42GRK11.06565268
43ITK1.04311374
44BUB11.03010050
45BRSK20.97535503
46STK100.94901468
47PASK0.93820531
48MYLK0.93576017
49NEK20.93253826
50IKBKB0.92493014
51RPS6KB20.91221116
52NEK10.85273677
53STK38L0.84000958
54PIM20.83946313
55DAPK10.80704218
56CDC70.78169018
57WEE10.76865688
58PLK10.76068604
59KIT0.73294241
60BMPR1B0.68451162
61FES0.66147164
62ATR0.65959130
63KDR0.64837000
64CSF1R0.63222335
65MAPKAPK50.62167934
66TESK20.57695753
67CHEK20.55592876
68JAK30.54234886
69ZAP700.52835985
70TAF10.51513687
71IGF1R0.50788870
72LCK0.49995464
73BCR0.49378397
74ALK0.49119848
75CSNK1G30.48637196
76CLK10.48198658
77SYK0.47063887
78AURKB0.45617845
79LYN0.45483203
80ATM0.44365287
81ERBB30.44364685
82CSNK1G10.44217030
83CDK90.42753244
84TBK10.42620945
85ABL10.42145625
86MATK0.41866800
87PIM10.38988676
88MAP3K140.38487684
89NME10.35844340
90HCK0.35553889
91STK40.34339090
92ILK0.34033003
93CSNK2A10.32367360
94PRKCQ0.32363096
95PIK3CG0.30220188
96DAPK30.29931592
97RPS6KA50.29183577
98EGFR0.28862270
99CSNK2A20.28766642
100PHKG20.27461732

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.70006084
2Proteasome_Homo sapiens_hsa030504.24777545
3RNA polymerase_Homo sapiens_hsa030202.87837149
4Asthma_Homo sapiens_hsa053102.45830922
5Ribosome_Homo sapiens_hsa030102.28106732
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.23069292
7Oxidative phosphorylation_Homo sapiens_hsa001902.15874319
8Mismatch repair_Homo sapiens_hsa034302.14697299
9Homologous recombination_Homo sapiens_hsa034402.06779876
10DNA replication_Homo sapiens_hsa030302.01369369
11Parkinsons disease_Homo sapiens_hsa050121.95710688
12Protein export_Homo sapiens_hsa030601.89080646
13Drug metabolism - other enzymes_Homo sapiens_hsa009831.87016747
14Allograft rejection_Homo sapiens_hsa053301.85144138
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.83487377
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.81030683
17Autoimmune thyroid disease_Homo sapiens_hsa053201.77316969
18Propanoate metabolism_Homo sapiens_hsa006401.68820051
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.68787687
20Graft-versus-host disease_Homo sapiens_hsa053321.67586939
21Pyrimidine metabolism_Homo sapiens_hsa002401.66891528
22Fanconi anemia pathway_Homo sapiens_hsa034601.66395350
23One carbon pool by folate_Homo sapiens_hsa006701.66300968
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62012131
25Fatty acid elongation_Homo sapiens_hsa000621.56604201
26Tryptophan metabolism_Homo sapiens_hsa003801.53926861
27Non-homologous end-joining_Homo sapiens_hsa034501.52981107
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.48953170
29Antigen processing and presentation_Homo sapiens_hsa046121.47583301
30Spliceosome_Homo sapiens_hsa030401.45993296
31Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.44607633
32Type I diabetes mellitus_Homo sapiens_hsa049401.43902552
33RNA degradation_Homo sapiens_hsa030181.42760543
34Base excision repair_Homo sapiens_hsa034101.40566721
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.39897281
36Basal transcription factors_Homo sapiens_hsa030221.35638109
37Nucleotide excision repair_Homo sapiens_hsa034201.35507670
38RNA transport_Homo sapiens_hsa030131.23463756
39Primary immunodeficiency_Homo sapiens_hsa053401.20311251
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19472957
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.18048259
42Sulfur metabolism_Homo sapiens_hsa009201.17184051
43Purine metabolism_Homo sapiens_hsa002301.09447529
44Alzheimers disease_Homo sapiens_hsa050101.04938920
45Pentose and glucuronate interconversions_Homo sapiens_hsa000401.04867912
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.03046801
47Chemical carcinogenesis_Homo sapiens_hsa052041.01974934
48Selenocompound metabolism_Homo sapiens_hsa004501.01788638
49Rheumatoid arthritis_Homo sapiens_hsa053231.01779524
50Huntingtons disease_Homo sapiens_hsa050160.98893673
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91592798
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.91334277
53Peroxisome_Homo sapiens_hsa041460.87517866
54Phototransduction_Homo sapiens_hsa047440.87328363
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86936657
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83882946
57Arachidonic acid metabolism_Homo sapiens_hsa005900.82927590
58Butanoate metabolism_Homo sapiens_hsa006500.82047937
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80717259
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.80175226
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79547696
62Pyruvate metabolism_Homo sapiens_hsa006200.73411015
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72526829
64Herpes simplex infection_Homo sapiens_hsa051680.72514764
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69905186
66Nitrogen metabolism_Homo sapiens_hsa009100.69723633
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68320949
68Glutathione metabolism_Homo sapiens_hsa004800.67849262
69Cell cycle_Homo sapiens_hsa041100.66821162
70beta-Alanine metabolism_Homo sapiens_hsa004100.66290621
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65861230
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.65529083
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63994122
74Metabolic pathways_Homo sapiens_hsa011000.63784550
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.63111078
76Retinol metabolism_Homo sapiens_hsa008300.62794283
77Collecting duct acid secretion_Homo sapiens_hsa049660.62412084
78Fatty acid metabolism_Homo sapiens_hsa012120.58742902
79Leishmaniasis_Homo sapiens_hsa051400.56014047
80Hematopoietic cell lineage_Homo sapiens_hsa046400.49267210
81Linoleic acid metabolism_Homo sapiens_hsa005910.48354237
82Carbon metabolism_Homo sapiens_hsa012000.46571954
83Staphylococcus aureus infection_Homo sapiens_hsa051500.45782657
84Viral myocarditis_Homo sapiens_hsa054160.43986352
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43829533
86Epstein-Barr virus infection_Homo sapiens_hsa051690.43284917
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42481831
88Fatty acid degradation_Homo sapiens_hsa000710.42080179
89N-Glycan biosynthesis_Homo sapiens_hsa005100.42029313
90Systemic lupus erythematosus_Homo sapiens_hsa053220.39977017
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38243466
92Regulation of autophagy_Homo sapiens_hsa041400.36219194
93p53 signaling pathway_Homo sapiens_hsa041150.36206065
94Olfactory transduction_Homo sapiens_hsa047400.35502775
95Ether lipid metabolism_Homo sapiens_hsa005650.35210427
96Oocyte meiosis_Homo sapiens_hsa041140.35191627
97Fatty acid biosynthesis_Homo sapiens_hsa000610.32411575
98Vitamin digestion and absorption_Homo sapiens_hsa049770.29051594
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27154250
100Shigellosis_Homo sapiens_hsa051310.23693641

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