ZNF821

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with two C2H2 zinc finger motifs and a score-and-three (23)-amino acid peptide repeat (STPR) domain. The STPR domain of the encoded protein binds to double stranded DNA and may also contain a nuclear localization signal, suggesting that this protein interacts with chromosomal DNA. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)7.99934673
2nucleobase catabolic process (GO:0046113)6.32193853
3behavioral response to nicotine (GO:0035095)4.42589089
4postsynaptic membrane organization (GO:0001941)4.42077922
5neuron cell-cell adhesion (GO:0007158)4.40162109
6gamma-aminobutyric acid transport (GO:0015812)4.38021748
7protein localization to synapse (GO:0035418)4.19861024
8establishment of mitochondrion localization (GO:0051654)4.14847077
9synaptic vesicle maturation (GO:0016188)4.10829290
10synaptic vesicle exocytosis (GO:0016079)4.07738079
11axonal fasciculation (GO:0007413)4.04815589
12presynaptic membrane organization (GO:0097090)3.97090032
13ionotropic glutamate receptor signaling pathway (GO:0035235)3.91555919
14presynaptic membrane assembly (GO:0097105)3.89892562
15negative regulation of synaptic transmission, GABAergic (GO:0032229)3.86115760
16cell migration in hindbrain (GO:0021535)3.84096475
17neuron recognition (GO:0008038)3.82364389
18positive regulation of mitochondrial fission (GO:0090141)3.76961243
19regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.69221481
20regulation of synaptic vesicle exocytosis (GO:2000300)3.66291902
21DNA methylation involved in gamete generation (GO:0043046)3.65525039
22negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.60612500
23synaptic transmission, glutamatergic (GO:0035249)3.59523003
24regulation of synapse structural plasticity (GO:0051823)3.57921879
25positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.55519740
26regulation of short-term neuronal synaptic plasticity (GO:0048172)3.55000895
27dendritic spine morphogenesis (GO:0060997)3.54021742
28synapse assembly (GO:0007416)3.53105054
29vocalization behavior (GO:0071625)3.49288632
30piRNA metabolic process (GO:0034587)3.36237438
31hippocampus development (GO:0021766)3.36159650
32auditory behavior (GO:0031223)3.35056890
33glutamate receptor signaling pathway (GO:0007215)3.29354578
34calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.28734846
35ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.28537511
36startle response (GO:0001964)3.24569958
37sympathetic nervous system development (GO:0048485)3.23006940
38neurotransmitter secretion (GO:0007269)3.22248917
39glutamate secretion (GO:0014047)3.16862288
40neuronal action potential propagation (GO:0019227)3.16851719
41regulation of synaptic vesicle transport (GO:1902803)3.13909391
42transmission of nerve impulse (GO:0019226)3.10498049
43neurofilament cytoskeleton organization (GO:0060052)3.09037293
44central nervous system projection neuron axonogenesis (GO:0021952)3.08855212
45nonmotile primary cilium assembly (GO:0035058)3.08794416
46spinal cord development (GO:0021510)3.06869392
47protein polyglutamylation (GO:0018095)3.06261949
48positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.02870756
49forebrain neuron differentiation (GO:0021879)3.02344869
50retinal ganglion cell axon guidance (GO:0031290)3.02231241
51G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.01233342
52neuron-neuron synaptic transmission (GO:0007270)3.00635902
53olfactory bulb development (GO:0021772)3.00548325
54negative regulation of oligodendrocyte differentiation (GO:0048715)3.00228366
55glycosphingolipid biosynthetic process (GO:0006688)2.99741326
56neurotransmitter-gated ion channel clustering (GO:0072578)2.99379855
57regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.98259352
58neuronal ion channel clustering (GO:0045161)2.98208415
59somite development (GO:0061053)2.95627331
60dendrite morphogenesis (GO:0048813)2.95454910
61gamma-aminobutyric acid signaling pathway (GO:0007214)2.93387005
62ribonucleoprotein complex disassembly (GO:0032988)2.93312975
63response to auditory stimulus (GO:0010996)2.91686975
64layer formation in cerebral cortex (GO:0021819)2.90594697
65positive regulation of synapse assembly (GO:0051965)2.88374098
66ganglion development (GO:0061548)2.85017464
67head development (GO:0060322)2.84749262
68mechanosensory behavior (GO:0007638)2.84636551
69regulation of meiosis I (GO:0060631)2.82228918
70limb bud formation (GO:0060174)2.79096973
71positive regulation of synapse maturation (GO:0090129)2.74983344
72epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.72956823
73establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.72956690
74mitochondrion transport along microtubule (GO:0047497)2.72956690
75tachykinin receptor signaling pathway (GO:0007217)2.72908844
76regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.71489539
77substrate-independent telencephalic tangential migration (GO:0021826)2.70331447
78substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.70331447
79protein localization to cilium (GO:0061512)2.70230949
80regulation of vesicle fusion (GO:0031338)2.69262027
81mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.68353178
82positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.68353178
83synapse organization (GO:0050808)2.68136761
84regulation of respiratory system process (GO:0044065)2.66253493
85neural tube formation (GO:0001841)2.66119742
86regulation of neurotransmitter levels (GO:0001505)2.65912118
87synaptic transmission, cholinergic (GO:0007271)2.65073168
88nervous system development (GO:0007399)2.64588798
89regulation of development, heterochronic (GO:0040034)2.64273053
90behavioral response to ethanol (GO:0048149)2.64068754
91exploration behavior (GO:0035640)2.63352926
92neuron migration (GO:0001764)2.62206895
93regulation of synaptic transmission, glutamatergic (GO:0051966)2.62158739
94neuromuscular synaptic transmission (GO:0007274)2.61636251
95central nervous system neuron axonogenesis (GO:0021955)2.59612978
96regulation of feeding behavior (GO:0060259)2.59321279
97regulation of microtubule-based movement (GO:0060632)2.57789297
98sequestering of actin monomers (GO:0042989)2.56341437
99neurotransmitter transport (GO:0006836)2.56263434
100glial cell proliferation (GO:0014009)2.54916620

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.59497430
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse4.14105028
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.20476791
4GBX2_23144817_ChIP-Seq_PC3_Human3.04740224
5IGF1R_20145208_ChIP-Seq_DFB_Human2.98139254
6ZNF274_21170338_ChIP-Seq_K562_Hela2.82101996
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.76507069
8REST_21632747_ChIP-Seq_MESCs_Mouse2.55913536
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.49445009
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.48946048
11CBX2_27304074_Chip-Seq_ESCs_Mouse2.43178667
12REST_18959480_ChIP-ChIP_MESCs_Mouse2.37208900
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.23804375
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.23671684
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.16362322
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.15476426
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.11535704
18RNF2_27304074_Chip-Seq_NSC_Mouse2.04394883
19TAF15_26573619_Chip-Seq_HEK293_Human2.00227460
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.95852995
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.91593591
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89833907
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.89041389
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88970121
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.88532351
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.87705995
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.76999787
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73474986
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.71455953
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70377330
31EZH2_18974828_ChIP-Seq_MESCs_Mouse1.67902526
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.67902526
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67568810
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.66556716
35AR_21572438_ChIP-Seq_LNCaP_Human1.63850280
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.58375291
37SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.52500352
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49494414
39P300_19829295_ChIP-Seq_ESCs_Human1.46236307
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.45834012
41FUS_26573619_Chip-Seq_HEK293_Human1.45174745
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42228485
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.41133848
44DROSHA_22980978_ChIP-Seq_HELA_Human1.40952760
45FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.39398356
46SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.39117870
47RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.38498167
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35279122
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35279122
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31748627
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29661905
52EWS_26573619_Chip-Seq_HEK293_Human1.26448488
53VDR_22108803_ChIP-Seq_LS180_Human1.25730245
54RARB_27405468_Chip-Seq_BRAIN_Mouse1.25250379
55MTF2_20144788_ChIP-Seq_MESCs_Mouse1.24809453
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24255375
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20684149
58RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20394387
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17672837
60RING1B_27294783_Chip-Seq_ESCs_Mouse1.17239341
61AR_25329375_ChIP-Seq_VCAP_Human1.15886011
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15062412
63CBP_20019798_ChIP-Seq_JUKART_Human1.15051289
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15051289
65CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13117136
66IRF1_19129219_ChIP-ChIP_H3396_Human1.13078315
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12087839
68SMAD4_21799915_ChIP-Seq_A2780_Human1.11494795
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08282941
70ER_23166858_ChIP-Seq_MCF-7_Human1.06547317
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04052620
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.03718747
73AR_19668381_ChIP-Seq_PC3_Human1.02353645
74CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01799304
75RUNX2_22187159_ChIP-Seq_PCA_Human1.00979332
76CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00201859
77TP53_22573176_ChIP-Seq_HFKS_Human1.00015267
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98843019
79STAT3_23295773_ChIP-Seq_U87_Human0.98394040
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97575167
81TAL1_26923725_Chip-Seq_HPCs_Mouse0.97057890
82SMAD3_21741376_ChIP-Seq_EPCs_Human0.97047560
83TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96933812
84GATA1_26923725_Chip-Seq_HPCs_Mouse0.96928459
85E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.96383904
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96253970
87TCF4_23295773_ChIP-Seq_U87_Human0.96002436
88GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92810024
89KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92312045
90FLI1_27457419_Chip-Seq_LIVER_Mouse0.91159678
91SOX2_16153702_ChIP-ChIP_HESCs_Human0.89552449
92PIAS1_25552417_ChIP-Seq_VCAP_Human0.88253826
93OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.87812834
94KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.86801829
95SOX2_21211035_ChIP-Seq_LN229_Gbm0.86343965
96TP53_20018659_ChIP-ChIP_R1E_Mouse0.86207554
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85938883
98SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.85351334
99ETV2_25802403_ChIP-Seq_MESCs_Mouse0.83248671
100RING1B_27294783_Chip-Seq_NPCs_Mouse0.83008012

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.60467548
2MP0004859_abnormal_synaptic_plasticity3.44909301
3MP0002653_abnormal_ependyma_morphology3.15565273
4MP0005423_abnormal_somatic_nervous3.08998545
5MP0004270_analgesia2.88484498
6MP0000778_abnormal_nervous_system2.77671471
7MP0003122_maternal_imprinting2.65148104
8MP0002837_dystrophic_cardiac_calcinosis2.53750663
9MP0009046_muscle_twitch2.52413694
10MP0003635_abnormal_synaptic_transmissio2.52239097
11MP0003787_abnormal_imprinting2.43972469
12MP0006276_abnormal_autonomic_nervous2.37222349
13MP0009745_abnormal_behavioral_response2.28726237
14MP0002638_abnormal_pupillary_reflex2.28274108
15MP0002063_abnormal_learning/memory/cond2.21179594
16MP0002064_seizures2.18101364
17MP0001984_abnormal_olfaction2.16023722
18MP0002272_abnormal_nervous_system2.13031190
19MP0003890_abnormal_embryonic-extraembry2.11647866
20MP0002572_abnormal_emotion/affect_behav2.07420528
21MP0003121_genomic_imprinting2.07257945
22MP0001529_abnormal_vocalization2.03913537
23MP0003136_yellow_coat_color1.96428381
24MP0008877_abnormal_DNA_methylation1.96071672
25MP0005394_taste/olfaction_phenotype1.95687556
26MP0005499_abnormal_olfactory_system1.95687556
27MP0002822_catalepsy1.92941836
28MP0001486_abnormal_startle_reflex1.92095822
29MP0001968_abnormal_touch/_nociception1.84765525
30MP0002557_abnormal_social/conspecific_i1.77721221
31MP0002735_abnormal_chemical_nociception1.75902861
32MP0005171_absent_coat_pigmentation1.72873387
33MP0002734_abnormal_mechanical_nocicepti1.70776921
34MP0002184_abnormal_innervation1.69589786
35MP0006292_abnormal_olfactory_placode1.65872115
36MP0008789_abnormal_olfactory_epithelium1.64557802
37MP0002736_abnormal_nociception_after1.63896933
38MP0004811_abnormal_neuron_physiology1.58421104
39MP0000955_abnormal_spinal_cord1.56126637
40MP0000631_abnormal_neuroendocrine_gland1.52576338
41MP0004142_abnormal_muscle_tone1.51948721
42MP0002882_abnormal_neuron_morphology1.51664210
43MP0003879_abnormal_hair_cell1.48457223
44MP0002067_abnormal_sensory_capabilities1.46882084
45MP0004742_abnormal_vestibular_system1.46818167
46MP0001188_hyperpigmentation1.46557941
47MP0003646_muscle_fatigue1.46016092
48MP0001970_abnormal_pain_threshold1.45330222
49MP0000049_abnormal_middle_ear1.45146749
50MP0002751_abnormal_autonomic_nervous1.44431324
51MP0002102_abnormal_ear_morphology1.39736349
52MP0004885_abnormal_endolymph1.38369578
53MP0005645_abnormal_hypothalamus_physiol1.36465448
54MP0001986_abnormal_taste_sensitivity1.35733244
55MP0002733_abnormal_thermal_nociception1.33976297
56MP0002909_abnormal_adrenal_gland1.33612888
57MP0006072_abnormal_retinal_apoptosis1.29581001
58MP0001502_abnormal_circadian_rhythm1.28060608
59MP0001501_abnormal_sleep_pattern1.25212476
60MP0005253_abnormal_eye_physiology1.24038593
61MP0005551_abnormal_eye_electrophysiolog1.23188056
62MP0002152_abnormal_brain_morphology1.21747955
63MP0008995_early_reproductive_senescence1.21529083
64MP0000569_abnormal_digit_pigmentation1.18372379
65MP0002752_abnormal_somatic_nervous1.17710252
66MP0005386_behavior/neurological_phenoty1.17394946
67MP0004924_abnormal_behavior1.17394946
68MP0001905_abnormal_dopamine_level1.14893489
69MP0000026_abnormal_inner_ear1.14350061
70MP0002066_abnormal_motor_capabilities/c1.10036696
71MP0004147_increased_porphyrin_level1.07961574
72MP0003119_abnormal_digestive_system1.07896119
73MP0003011_delayed_dark_adaptation1.03977319
74MP0003861_abnormal_nervous_system1.02356715
75MP0001485_abnormal_pinna_reflex1.01787652
76MP0008569_lethality_at_weaning1.01685760
77MP0004133_heterotaxia1.00132149
78MP0001963_abnormal_hearing_physiology0.96820160
79MP0003123_paternal_imprinting0.93101783
80MP0002938_white_spotting0.92530985
81MP0003938_abnormal_ear_development0.92263487
82MP0002234_abnormal_pharynx_morphology0.88707350
83MP0002928_abnormal_bile_duct0.86755786
84MP0001440_abnormal_grooming_behavior0.83524969
85MP0002069_abnormal_eating/drinking_beha0.83516867
86MP0003137_abnormal_impulse_conducting0.81914413
87MP0002229_neurodegeneration0.81561385
88MP0005646_abnormal_pituitary_gland0.75731681
89MP0003385_abnormal_body_wall0.74555872
90MP0003698_abnormal_male_reproductive0.73238298
91MP0005167_abnormal_blood-brain_barrier0.69867388
92MP0005195_abnormal_posterior_eye0.69269446
93MP0004043_abnormal_pH_regulation0.68269185
94MP0002210_abnormal_sex_determination0.67412703
95MP0004145_abnormal_muscle_electrophysio0.66382071
96MP0001177_atelectasis0.65812172
97MP0000566_synostosis0.65209715
98MP0005391_vision/eye_phenotype0.64925537
99MP0002081_perinatal_lethality0.64845785
100MP0005187_abnormal_penis_morphology0.63633545

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.34740006
2Limb dystonia (HP:0002451)4.18970595
3Focal seizures (HP:0007359)3.68051051
4Polyphagia (HP:0002591)3.51485596
5Drooling (HP:0002307)3.27998867
6Myokymia (HP:0002411)3.25830151
7Cortical dysplasia (HP:0002539)3.20201294
8Gait imbalance (HP:0002141)3.13474812
9Nephronophthisis (HP:0000090)3.08489537
10Lissencephaly (HP:0001339)3.07353691
11Retinal dysplasia (HP:0007973)3.06006283
12Excessive salivation (HP:0003781)3.04943103
13Broad-based gait (HP:0002136)3.01250355
14Dialeptic seizures (HP:0011146)2.90605706
15Amyotrophic lateral sclerosis (HP:0007354)2.86065036
16Hypoplasia of the brainstem (HP:0002365)2.85708982
17Aplasia/Hypoplasia of the brainstem (HP:0007362)2.85708982
18Urinary urgency (HP:0000012)2.82633371
19Medial flaring of the eyebrow (HP:0010747)2.81999029
20Progressive cerebellar ataxia (HP:0002073)2.79857105
21Abnormality of the corticospinal tract (HP:0002492)2.73834072
22Hypsarrhythmia (HP:0002521)2.72689280
23Pancreatic cysts (HP:0001737)2.70846122
24Congenital primary aphakia (HP:0007707)2.69838440
25Pachygyria (HP:0001302)2.67943052
26Peripheral hypomyelination (HP:0007182)2.64315781
27EEG with generalized epileptiform discharges (HP:0011198)2.61072463
28Epileptiform EEG discharges (HP:0011182)2.60264294
29Impaired vibration sensation in the lower limbs (HP:0002166)2.60187866
30Absent speech (HP:0001344)2.54569187
31Nephrogenic diabetes insipidus (HP:0009806)2.54115000
32Degeneration of the lateral corticospinal tracts (HP:0002314)2.52243108
33Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.52243108
34Spastic gait (HP:0002064)2.50204514
35Febrile seizures (HP:0002373)2.49768372
36Abnormality of the labia minora (HP:0012880)2.49242420
37Abnormality of the renal medulla (HP:0100957)2.48738110
38Hepatoblastoma (HP:0002884)2.46282000
39Ankle clonus (HP:0011448)2.44348574
40Thyroid-stimulating hormone excess (HP:0002925)2.43991465
41Abnormality of the lower motor neuron (HP:0002366)2.43709969
42Generalized tonic-clonic seizures (HP:0002069)2.43116833
43Epileptic encephalopathy (HP:0200134)2.42112717
44Shoulder girdle muscle weakness (HP:0003547)2.41914253
45Abnormal eating behavior (HP:0100738)2.41146256
46Type II lissencephaly (HP:0007260)2.35142965
47Oligodactyly (hands) (HP:0001180)2.35137579
48Spastic tetraplegia (HP:0002510)2.33666903
49Specific learning disability (HP:0001328)2.33321797
50Agitation (HP:0000713)2.32446606
51Inability to walk (HP:0002540)2.30715780
52Atonic seizures (HP:0010819)2.29140529
53Split foot (HP:0001839)2.28995879
54Hyperventilation (HP:0002883)2.26601992
55Morphological abnormality of the pyramidal tract (HP:0002062)2.21556658
56Abnormality of midbrain morphology (HP:0002418)2.19049242
57Molar tooth sign on MRI (HP:0002419)2.19049242
58Intestinal atresia (HP:0011100)2.15572608
59True hermaphroditism (HP:0010459)2.14062406
60Esotropia (HP:0000565)2.12665722
61Vaginal atresia (HP:0000148)2.11535485
62Pancreatic fibrosis (HP:0100732)2.10891417
63Broad alveolar ridges (HP:0000187)2.10728705
64Genital tract atresia (HP:0001827)2.10691965
65Amblyopia (HP:0000646)2.09181642
66Ulnar claw (HP:0001178)2.06984756
67Urinary bladder sphincter dysfunction (HP:0002839)2.06763229
68Mutism (HP:0002300)2.05573221
69Abnormality of the musculature of the pelvis (HP:0001469)2.03061559
70Abnormality of the hip-girdle musculature (HP:0001445)2.03061559
71Hypoplasia of the corpus callosum (HP:0002079)2.02387390
72Optic nerve hypoplasia (HP:0000609)1.99782812
73Poor coordination (HP:0002370)1.99354562
74Hyperglycinemia (HP:0002154)1.99095662
75Generalized myoclonic seizures (HP:0002123)1.97841205
76Pendular nystagmus (HP:0012043)1.97817668
77Hemiparesis (HP:0001269)1.97085327
78Exotropia (HP:0000577)1.95599851
79Absence seizures (HP:0002121)1.92825956
80Failure to thrive in infancy (HP:0001531)1.92618319
81Neonatal respiratory distress (HP:0002643)1.90210463
82Atrophy/Degeneration involving motor neurons (HP:0007373)1.89518326
83Progressive inability to walk (HP:0002505)1.86889759
84Parakeratosis (HP:0001036)1.85426035
85Genetic anticipation (HP:0003743)1.85065333
86Sleep apnea (HP:0010535)1.84927649
87Status epilepticus (HP:0002133)1.84731999
88Postaxial hand polydactyly (HP:0001162)1.84445358
89Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.83782900
90Retinitis pigmentosa (HP:0000510)1.82696450
91Paraplegia (HP:0010550)1.82602492
92Colon cancer (HP:0003003)1.81758459
93Action tremor (HP:0002345)1.80126212
94Oligodactyly (HP:0012165)1.78343185
95Lower limb muscle weakness (HP:0007340)1.78187558
96Muscular hypotonia of the trunk (HP:0008936)1.77290993
97Narrow forehead (HP:0000341)1.73258747
98Poor suck (HP:0002033)1.70490009
99Broad foot (HP:0001769)1.70249222
100Chronic hepatic failure (HP:0100626)1.70231419

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.59812914
2MAP3K44.22762140
3MAP2K73.79134987
4LATS13.27080705
5CASK2.85207027
6BCR2.67528955
7TRIM282.62528421
8MAP4K22.54753104
9DYRK22.42403354
10MAPK132.20041404
11CDK192.19701890
12EPHA42.17281254
13NTRK22.06724118
14STK38L2.00132464
15ZAK1.93315669
16WNK31.93252418
17SIK21.86154002
18UHMK11.82036013
19CSNK1G21.71241426
20MAP2K41.66651536
21CSNK1A1L1.62413569
22LATS21.59489473
23CSNK1G31.55776054
24DYRK31.49814102
25PINK11.48958354
26NTRK31.38865165
27DYRK1B1.38719696
28EPHA31.29499314
29MAP3K91.28858059
30CSNK1G11.26575090
31PRKD31.18940892
32MINK11.17922815
33PRKCG1.15358520
34RPS6KA41.15226925
35PAK61.14763038
36CDK51.11227753
37EPHB21.10432140
38BMPR1B1.05987984
39CAMKK21.03702223
40DAPK21.03068563
41BCKDK0.99361453
42PKN10.96948584
43ERBB30.96053025
44DYRK1A0.92802581
45FRK0.92151808
46PNCK0.90546721
47KSR10.87775762
48PAK30.84923290
49ADRBK20.84436977
50CAMK2B0.82914219
51CAMK40.82703806
52SRPK10.82603854
53MAP3K60.79618720
54SGK2230.77110968
55SGK4940.77110968
56CDK30.71461501
57CAMKK10.71210693
58STK380.69223911
59SIK30.69116006
60CDK140.65275108
61CAMK2A0.64333615
62PRKCZ0.64051956
63MAP3K50.61570101
64CDK180.60046668
65CDK11A0.59478674
66CAMK10.59244048
67PRKCE0.55575718
68CDK150.53346783
69PHKG20.50224063
70PHKG10.50224063
71CSNK1D0.50061331
72GRK10.48923282
73SGK20.48303743
74LIMK10.47800584
75PRKAA10.47586626
76MAP2K20.47438173
77PLK20.46896751
78RPS6KA50.46778007
79MAPK150.45333115
80VRK10.43916026
81TYRO30.43888202
82STK110.42532258
83GRK50.41386104
84KSR20.39772212
85PRKACA0.39511314
86CSNK1A10.34772622
87CCNB10.33903757
88CSNK1E0.33745018
89ADRBK10.31557640
90TESK10.30546873
91PRKACB0.30052710
92TLK10.28895272
93MAPK90.28813131
94CAMK2G0.28609918
95OXSR10.25694077
96MARK20.25536401
97GSK3B0.24109451
98TAOK10.22012376
99MAPK80.21250172
100PRKD10.20637545

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050335.19121641
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.36338307
3GABAergic synapse_Homo sapiens_hsa047273.12313927
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.94423977
5Synaptic vesicle cycle_Homo sapiens_hsa047212.85885818
6Phototransduction_Homo sapiens_hsa047442.78251814
7Morphine addiction_Homo sapiens_hsa050322.67731355
8Glutamatergic synapse_Homo sapiens_hsa047242.29243108
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.15362641
10Circadian entrainment_Homo sapiens_hsa047132.05640753
11Cocaine addiction_Homo sapiens_hsa050302.01420363
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.95827636
13Dopaminergic synapse_Homo sapiens_hsa047281.92159333
14Taste transduction_Homo sapiens_hsa047421.91475545
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.73414224
16Collecting duct acid secretion_Homo sapiens_hsa049661.71129710
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.70831052
18Steroid biosynthesis_Homo sapiens_hsa001001.65344242
19Axon guidance_Homo sapiens_hsa043601.62927759
20Butanoate metabolism_Homo sapiens_hsa006501.62169195
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.59275934
22Basal transcription factors_Homo sapiens_hsa030221.59209286
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50160696
24Oxidative phosphorylation_Homo sapiens_hsa001901.49237705
25Amphetamine addiction_Homo sapiens_hsa050311.49034183
26Cholinergic synapse_Homo sapiens_hsa047251.45665964
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.43772588
28Cardiac muscle contraction_Homo sapiens_hsa042601.40078674
29Serotonergic synapse_Homo sapiens_hsa047261.38413405
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.37334428
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.35284760
32Insulin secretion_Homo sapiens_hsa049111.28392377
33Regulation of autophagy_Homo sapiens_hsa041401.24008451
34Parkinsons disease_Homo sapiens_hsa050121.19285538
35Long-term depression_Homo sapiens_hsa047301.17155190
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.16693128
37Olfactory transduction_Homo sapiens_hsa047401.10494565
38Gap junction_Homo sapiens_hsa045401.00108696
39Vibrio cholerae infection_Homo sapiens_hsa051100.97037473
40Type II diabetes mellitus_Homo sapiens_hsa049300.95033420
41Circadian rhythm_Homo sapiens_hsa047100.93200163
42cAMP signaling pathway_Homo sapiens_hsa040240.92077272
43Alcoholism_Homo sapiens_hsa050340.92019106
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91672490
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91272393
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90342962
47Hedgehog signaling pathway_Homo sapiens_hsa043400.87989688
48Basal cell carcinoma_Homo sapiens_hsa052170.85803769
49Dorso-ventral axis formation_Homo sapiens_hsa043200.82639780
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.82138656
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81205080
52Calcium signaling pathway_Homo sapiens_hsa040200.80012865
53Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78873907
54Huntingtons disease_Homo sapiens_hsa050160.78062201
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.76823684
56Oxytocin signaling pathway_Homo sapiens_hsa049210.75092544
57Hippo signaling pathway_Homo sapiens_hsa043900.70397108
58Alzheimers disease_Homo sapiens_hsa050100.69493476
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68751073
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68387266
61Gastric acid secretion_Homo sapiens_hsa049710.67790780
62Oocyte meiosis_Homo sapiens_hsa041140.66796994
63Ether lipid metabolism_Homo sapiens_hsa005650.66312443
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65922440
65Salivary secretion_Homo sapiens_hsa049700.64215885
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63687546
67Sphingolipid metabolism_Homo sapiens_hsa006000.63465030
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59300296
69Long-term potentiation_Homo sapiens_hsa047200.58233046
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56953675
71Protein export_Homo sapiens_hsa030600.51698595
72Linoleic acid metabolism_Homo sapiens_hsa005910.51310503
73Melanogenesis_Homo sapiens_hsa049160.49475689
74Ras signaling pathway_Homo sapiens_hsa040140.48823749
75AMPK signaling pathway_Homo sapiens_hsa041520.47947751
76Sulfur relay system_Homo sapiens_hsa041220.44526377
77RNA degradation_Homo sapiens_hsa030180.44417916
78Ovarian steroidogenesis_Homo sapiens_hsa049130.42670372
79Phenylalanine metabolism_Homo sapiens_hsa003600.40229418
80beta-Alanine metabolism_Homo sapiens_hsa004100.39438246
81Wnt signaling pathway_Homo sapiens_hsa043100.39410039
82Colorectal cancer_Homo sapiens_hsa052100.38967818
83ErbB signaling pathway_Homo sapiens_hsa040120.36479855
84Dilated cardiomyopathy_Homo sapiens_hsa054140.35852793
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35575532
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.34649759
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34108007
88mRNA surveillance pathway_Homo sapiens_hsa030150.33419050
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33026974
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32843689
91MAPK signaling pathway_Homo sapiens_hsa040100.29749609
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28829001
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28279870
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27782227
95Fanconi anemia pathway_Homo sapiens_hsa034600.25233395
96Estrogen signaling pathway_Homo sapiens_hsa049150.24761956
97Selenocompound metabolism_Homo sapiens_hsa004500.23690905
98Peroxisome_Homo sapiens_hsa041460.22906949
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22221636
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21992767

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