ZNF823

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)5.23760907
2proteasome assembly (GO:0043248)5.21542565
3protein K6-linked ubiquitination (GO:0085020)5.14908687
4ribosome assembly (GO:0042255)4.42597046
5regulation of centriole replication (GO:0046599)4.14967886
6replication fork processing (GO:0031297)4.02797624
7DNA ligation (GO:0006266)3.78604122
8synapsis (GO:0007129)3.78184038
9mitotic sister chromatid cohesion (GO:0007064)3.70434783
10regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.61130436
11DNA catabolic process, exonucleolytic (GO:0000738)3.56204370
12negative regulation of astrocyte differentiation (GO:0048712)3.49309314
13regulation of meiosis I (GO:0060631)3.39029568
14chromatin remodeling at centromere (GO:0031055)3.36990688
15positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.35906734
16transcription from mitochondrial promoter (GO:0006390)3.33192184
17CENP-A containing nucleosome assembly (GO:0034080)3.32023350
18cell wall macromolecule metabolic process (GO:0044036)3.32021488
19regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.30701436
20anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.27504828
21maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.19103239
22negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.16295868
23establishment of integrated proviral latency (GO:0075713)3.15683007
24lactate metabolic process (GO:0006089)3.15438531
25regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.15310988
26water-soluble vitamin biosynthetic process (GO:0042364)3.11711088
27DNA replication-dependent nucleosome organization (GO:0034723)3.08080032
28DNA replication-dependent nucleosome assembly (GO:0006335)3.08080032
29postreplication repair (GO:0006301)3.07058841
30DNA replication checkpoint (GO:0000076)3.04745038
31DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.03705679
32signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.01323578
33signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.01323578
34signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.01323578
35positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.00818867
36histone exchange (GO:0043486)2.99878708
37non-recombinational repair (GO:0000726)2.98605576
38double-strand break repair via nonhomologous end joining (GO:0006303)2.98605576
39intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.97580216
40signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.97580216
41keratinocyte development (GO:0003334)2.97435716
42regulation of centrosome cycle (GO:0046605)2.97356495
43regulation of retinoic acid receptor signaling pathway (GO:0048385)2.97103246
44centriole replication (GO:0007099)2.95944405
45negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.95179754
46piRNA metabolic process (GO:0034587)2.89399793
47signal transduction involved in cell cycle checkpoint (GO:0072395)2.88928181
48regulation of cellular amino acid metabolic process (GO:0006521)2.88254163
49recombinational repair (GO:0000725)2.87644286
50double-strand break repair via homologous recombination (GO:0000724)2.87411245
51regulation of helicase activity (GO:0051095)2.86658194
52signal transduction involved in DNA integrity checkpoint (GO:0072401)2.86238673
53signal transduction involved in DNA damage checkpoint (GO:0072422)2.86238673
54positive regulation of ligase activity (GO:0051351)2.85837191
55protein neddylation (GO:0045116)2.84506114
56metaphase plate congression (GO:0051310)2.84247753
57mitochondrial RNA metabolic process (GO:0000959)2.84061349
58DNA integration (GO:0015074)2.83253474
59response to pheromone (GO:0019236)2.80831148
60establishment of protein localization to mitochondrial membrane (GO:0090151)2.79868875
61single strand break repair (GO:0000012)2.79533951
62response to X-ray (GO:0010165)2.75816805
63respiratory chain complex IV assembly (GO:0008535)2.74461895
64negative regulation of ligase activity (GO:0051352)2.73409141
65negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.73409141
66regulation of hexokinase activity (GO:1903299)2.72906201
67regulation of glucokinase activity (GO:0033131)2.72906201
68regulation of centrosome duplication (GO:0010824)2.72544191
69aerobic respiration (GO:0009060)2.72486243
70cellular respiration (GO:0045333)2.72086145
71somatic hypermutation of immunoglobulin genes (GO:0016446)2.71110467
72somatic diversification of immune receptors via somatic mutation (GO:0002566)2.71110467
73cullin deneddylation (GO:0010388)2.69857867
74mitotic sister chromatid segregation (GO:0000070)2.67466423
75platelet dense granule organization (GO:0060155)2.66194134
76somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.65748253
77somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.65748253
78isotype switching (GO:0045190)2.65748253
79DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.62049808
80negative regulation of neurological system process (GO:0031645)2.61159324
81pyrimidine dimer repair (GO:0006290)2.59212322
82meiotic cell cycle (GO:0051321)2.58450628
83sister chromatid segregation (GO:0000819)2.58365241
84negative regulation of DNA recombination (GO:0045910)2.57186779
85resolution of meiotic recombination intermediates (GO:0000712)2.55691300
86negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.54561646
87regulation of ubiquitin-protein transferase activity (GO:0051438)2.54227458
88male meiosis I (GO:0007141)2.54172472
89sister chromatid cohesion (GO:0007062)2.53956347
90midgut development (GO:0007494)2.52807279
91intraciliary transport (GO:0042073)2.51981959
92DNA replication-independent nucleosome organization (GO:0034724)2.49888709
93DNA replication-independent nucleosome assembly (GO:0006336)2.49888709
94RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.48454861
95mitotic metaphase plate congression (GO:0007080)2.47751118
96negative regulation of DNA-dependent DNA replication (GO:2000104)2.47667778
97regulation of DNA endoreduplication (GO:0032875)2.47658444
98exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.46914916
99kinetochore organization (GO:0051383)2.46084275
100DNA strand renaturation (GO:0000733)2.45963268

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human4.18638235
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.04533457
3E2F7_22180533_ChIP-Seq_HELA_Human3.99687585
4ZNF274_21170338_ChIP-Seq_K562_Hela3.53982871
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.01912605
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.01532951
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.95877552
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.65314502
9ELK1_19687146_ChIP-ChIP_HELA_Human2.54325357
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.39898509
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.24157170
12FUS_26573619_Chip-Seq_HEK293_Human2.22645139
13IGF1R_20145208_ChIP-Seq_DFB_Human2.19053285
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.18153414
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.13270413
16AR_21909140_ChIP-Seq_LNCAP_Human2.09813473
17EWS_26573619_Chip-Seq_HEK293_Human2.05665376
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.05608813
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.00663865
20PADI4_21655091_ChIP-ChIP_MCF-7_Human1.97066804
21PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95901646
22TAF15_26573619_Chip-Seq_HEK293_Human1.94518205
23VDR_23849224_ChIP-Seq_CD4+_Human1.93095216
24KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.92875124
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85206049
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.84833360
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.84441135
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80007563
29TP63_19390658_ChIP-ChIP_HaCaT_Human1.79792576
30FOXM1_23109430_ChIP-Seq_U2OS_Human1.76671921
31FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.76639284
32IRF1_19129219_ChIP-ChIP_H3396_Human1.75838519
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.75118177
34VDR_22108803_ChIP-Seq_LS180_Human1.69592184
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69536186
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.58479754
37P300_19829295_ChIP-Seq_ESCs_Human1.51414303
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.49576232
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.43780333
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39756261
41FOXP3_21729870_ChIP-Seq_TREG_Human1.39338478
42MYC_18555785_ChIP-Seq_MESCs_Mouse1.37722258
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37112322
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34616508
45* NOTCH1_21737748_ChIP-Seq_TLL_Human1.34063681
46NELFA_20434984_ChIP-Seq_ESCs_Mouse1.33565916
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33019600
48CBP_20019798_ChIP-Seq_JUKART_Human1.32613595
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32613595
50MYC_18940864_ChIP-ChIP_HL60_Human1.30921417
51TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.30895545
52ER_23166858_ChIP-Seq_MCF-7_Human1.30191068
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.29650780
54PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.29035932
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28163630
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27384496
57GBX2_23144817_ChIP-Seq_PC3_Human1.24956632
58DCP1A_22483619_ChIP-Seq_HELA_Human1.21285525
59MYC_19030024_ChIP-ChIP_MESCs_Mouse1.20915585
60BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.19456253
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17607093
62AR_25329375_ChIP-Seq_VCAP_Human1.17414569
63FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16528152
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.15886509
65HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.14042942
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.13805711
67RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.13799283
68GABP_19822575_ChIP-Seq_HepG2_Human1.11981621
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10194049
70MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09933615
71NANOG_16153702_ChIP-ChIP_HESCs_Human1.07886768
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07458463
73THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06800849
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05486832
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05152370
76PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04799610
77ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04288659
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03528744
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03125705
80CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01840520
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01095900
82SMAD4_21799915_ChIP-Seq_A2780_Human1.00822109
83KDM5A_27292631_Chip-Seq_BREAST_Human1.00267303
84TTF2_22483619_ChIP-Seq_HELA_Human0.99881927
85ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98003378
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97767910
87* ELF5_23300383_ChIP-Seq_T47D_Human0.97419192
88E2F1_18555785_ChIP-Seq_MESCs_Mouse0.96244730
89TCF4_22108803_ChIP-Seq_LS180_Human0.95642321
90BCAT_22108803_ChIP-Seq_LS180_Human0.95085930
91TCF4_23295773_ChIP-Seq_U87_Human0.95035096
92EGR1_23403033_ChIP-Seq_LIVER_Mouse0.95008489
93NANOG_19829295_ChIP-Seq_ESCs_Human0.94747077
94SOX2_19829295_ChIP-Seq_ESCs_Human0.94747077
95ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.93205803
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90417154
97MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88707671
98MYC_18358816_ChIP-ChIP_MESCs_Mouse0.88155398
99CDX2_22108803_ChIP-Seq_LS180_Human0.87821824
100STAT3_23295773_ChIP-Seq_U87_Human0.87733715

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.35476286
2MP0003693_abnormal_embryo_hatching3.10127582
3MP0003718_maternal_effect3.09215048
4MP0008058_abnormal_DNA_repair2.99114370
5MP0008057_abnormal_DNA_replication2.57726726
6MP0008995_early_reproductive_senescence2.45514374
7MP0000372_irregular_coat_pigmentation2.25165534
8MP0003195_calcinosis2.21693826
9MP0010234_abnormal_vibrissa_follicle2.20817658
10MP0008877_abnormal_DNA_methylation2.07766255
11MP0010307_abnormal_tumor_latency2.02607415
12MP0003077_abnormal_cell_cycle2.00571623
13MP0003786_premature_aging1.98095455
14MP0005408_hypopigmentation1.97370967
15MP0004957_abnormal_blastocyst_morpholog1.91332206
16MP0003937_abnormal_limbs/digits/tail_de1.85986825
17MP0008932_abnormal_embryonic_tissue1.82299595
18MP0003111_abnormal_nucleus_morphology1.80748285
19MP0005084_abnormal_gallbladder_morpholo1.71842285
20MP0002938_white_spotting1.68147847
21MP0005367_renal/urinary_system_phenotyp1.65914701
22MP0000516_abnormal_urinary_system1.65914701
23MP0005646_abnormal_pituitary_gland1.65557427
24MP0002282_abnormal_trachea_morphology1.60716915
25MP0003943_abnormal_hepatobiliary_system1.59490693
26MP0001529_abnormal_vocalization1.57680109
27MP0001293_anophthalmia1.54563447
28MP0004264_abnormal_extraembryonic_tissu1.53474603
29MP0004133_heterotaxia1.52857396
30MP0001929_abnormal_gametogenesis1.51371480
31MP0002928_abnormal_bile_duct1.49371513
32MP0008789_abnormal_olfactory_epithelium1.49175222
33MP0006292_abnormal_olfactory_placode1.49163235
34MP0000569_abnormal_digit_pigmentation1.49005694
35MP0001485_abnormal_pinna_reflex1.47522316
36MP0009697_abnormal_copulation1.46045197
37MP0005187_abnormal_penis_morphology1.41977169
38MP0000647_abnormal_sebaceous_gland1.39165515
39MP0000427_abnormal_hair_cycle1.38965147
40MP0003890_abnormal_embryonic-extraembry1.36742436
41MP0002160_abnormal_reproductive_system1.36654029
42MP0001177_atelectasis1.32162525
43MP0003868_abnormal_feces_composition1.31776648
44MP0000631_abnormal_neuroendocrine_gland1.31378173
45MP0002009_preneoplasia1.30799467
46MP0002736_abnormal_nociception_after1.29178205
47MP0008007_abnormal_cellular_replicative1.27599839
48MP0002751_abnormal_autonomic_nervous1.25336378
49MP0000613_abnormal_salivary_gland1.23506519
50MP0002210_abnormal_sex_determination1.22482795
51MP0005075_abnormal_melanosome_morpholog1.20636335
52MP0005395_other_phenotype1.17267648
53MP0005645_abnormal_hypothalamus_physiol1.17006042
54MP0006054_spinal_hemorrhage1.16957680
55MP0005551_abnormal_eye_electrophysiolog1.16303025
56MP0008872_abnormal_physiological_respon1.13826636
57MP0000653_abnormal_sex_gland1.13387658
58MP0008004_abnormal_stomach_pH1.10823349
59MP0004147_increased_porphyrin_level1.10714209
60MP0010030_abnormal_orbit_morphology1.09726469
61MP0003252_abnormal_bile_duct1.08416694
62MP0001145_abnormal_male_reproductive1.06548495
63MP0002277_abnormal_respiratory_mucosa1.01886261
64MP0010678_abnormal_skin_adnexa1.01842118
65MP0006072_abnormal_retinal_apoptosis1.01284757
66MP0003806_abnormal_nucleotide_metabolis1.00385566
67MP0001984_abnormal_olfaction0.99751581
68MP0003011_delayed_dark_adaptation0.99609959
69MP0002234_abnormal_pharynx_morphology0.97372537
70MP0005499_abnormal_olfactory_system0.94947580
71MP0005394_taste/olfaction_phenotype0.94947580
72MP0003755_abnormal_palate_morphology0.94644449
73MP0000015_abnormal_ear_pigmentation0.94123355
74MP0003698_abnormal_male_reproductive0.93706677
75MP0003136_yellow_coat_color0.93548934
76MP0002233_abnormal_nose_morphology0.93199339
77MP0005389_reproductive_system_phenotype0.91887736
78MP0003186_abnormal_redox_activity0.91371494
79MP0001764_abnormal_homeostasis0.90319241
80MP0005174_abnormal_tail_pigmentation0.89546489
81MP0001881_abnormal_mammary_gland0.89530472
82MP0003936_abnormal_reproductive_system0.87596336
83MP0008875_abnormal_xenobiotic_pharmacok0.87566045
84MP0001119_abnormal_female_reproductive0.86754177
85MP0002098_abnormal_vibrissa_morphology0.86698250
86MP0003315_abnormal_perineum_morphology0.85751104
87MP0002084_abnormal_developmental_patter0.85327767
88MP0005085_abnormal_gallbladder_physiolo0.85140627
89MP0005380_embryogenesis_phenotype0.84179019
90MP0001672_abnormal_embryogenesis/_devel0.84179019
91MP0000358_abnormal_cell_content/0.84026738
92MP0001324_abnormal_eye_pigmentation0.82545879
93MP0001666_abnormal_nutrient_absorption0.81914955
94MP0003567_abnormal_fetal_cardiomyocyte0.80542801
95MP0001697_abnormal_embryo_size0.79268466
96MP0006035_abnormal_mitochondrial_morpho0.76545382
97MP0001905_abnormal_dopamine_level0.76186635
98MP0005410_abnormal_fertilization0.76117611
99MP0002085_abnormal_embryonic_tissue0.75235604
100MP0005220_abnormal_exocrine_pancreas0.75050973

Predicted human phenotypes

RankGene SetZ-score
1Hypoplastic pelvis (HP:0008839)3.65737785
2Aplasia/Hypoplasia of the uvula (HP:0010293)3.55447189
3Meckel diverticulum (HP:0002245)3.44667069
4Abnormality of the ileum (HP:0001549)3.29929318
5Chronic hepatic failure (HP:0100626)3.25112532
6Abnormality of chromosome stability (HP:0003220)3.21769916
7Abnormality of the preputium (HP:0100587)3.15938392
8Abnormality of the astrocytes (HP:0100707)3.05082943
9Astrocytoma (HP:0009592)3.05082943
10Glioma (HP:0009733)2.97194590
11Abnormality of glycolysis (HP:0004366)2.88047504
12Volvulus (HP:0002580)2.87942933
13Increased serum pyruvate (HP:0003542)2.84893310
14Colon cancer (HP:0003003)2.81340843
15Pancreatic cysts (HP:0001737)2.81104278
16Rhabdomyosarcoma (HP:0002859)2.69272186
17True hermaphroditism (HP:0010459)2.69042983
18Abnormality of methionine metabolism (HP:0010901)2.67381937
19Small intestinal stenosis (HP:0012848)2.62852889
20Duodenal stenosis (HP:0100867)2.62852889
21Chromosomal breakage induced by crosslinking agents (HP:0003221)2.60925492
22Methylmalonic acidemia (HP:0002912)2.53752340
23Pancreatic fibrosis (HP:0100732)2.48972056
24Abnormality of the parathyroid morphology (HP:0011766)2.44752579
25Abnormality of aspartate family amino acid metabolism (HP:0010899)2.44257908
26Hyperglycinemia (HP:0002154)2.43064644
27Concave nail (HP:0001598)2.42954489
28Chromsome breakage (HP:0040012)2.42634623
29Small hand (HP:0200055)2.39950247
30Abnormality of the duodenum (HP:0002246)2.38723310
31Sloping forehead (HP:0000340)2.35690091
32Short tibia (HP:0005736)2.35551544
33Ependymoma (HP:0002888)2.35256951
34Meningioma (HP:0002858)2.31090629
35Pendular nystagmus (HP:0012043)2.21928586
36Aplasia/Hypoplasia of the tongue (HP:0010295)2.21384341
37Abnormality of the carotid arteries (HP:0005344)2.20945005
38Aplasia/Hypoplasia of the tibia (HP:0005772)2.19949063
39Abnormality of the vitamin B12 metabolism (HP:0004341)2.19792251
40Clubbing of toes (HP:0100760)2.18749675
41Abnormality of serum amino acid levels (HP:0003112)2.18487411
42Anencephaly (HP:0002323)2.16001432
43Abnormal lung lobation (HP:0002101)2.14594889
44Hypothermia (HP:0002045)2.13098207
45Abnormality of vitamin B metabolism (HP:0004340)2.06971657
46Ectopic kidney (HP:0000086)2.05895698
47Epiphyseal stippling (HP:0010655)2.04554188
48Aqueductal stenosis (HP:0002410)2.03449764
49Renal cortical cysts (HP:0000803)2.03072985
50Bile duct proliferation (HP:0001408)2.02149135
51Abnormal biliary tract physiology (HP:0012439)2.02149135
52Supernumerary spleens (HP:0009799)2.01175693
53Breast carcinoma (HP:0003002)2.00669524
54Triphalangeal thumb (HP:0001199)1.99419755
55Medial flaring of the eyebrow (HP:0010747)1.99388878
56Bifid tongue (HP:0010297)1.99351394
57Abnormality of midbrain morphology (HP:0002418)1.98004052
58Molar tooth sign on MRI (HP:0002419)1.98004052
59Median cleft lip (HP:0000161)1.97925700
60Tetraparesis (HP:0002273)1.97099288
61Adrenal hypoplasia (HP:0000835)1.95616509
62Abnormal umbilical cord blood vessels (HP:0011403)1.95266321
63Single umbilical artery (HP:0001195)1.95266321
64Abnormality of the fetal cardiovascular system (HP:0010948)1.95266321
65Hamartoma of the eye (HP:0010568)1.92270411
66Abnormality of the proximal phalanges of the hand (HP:0009834)1.88183467
67Short 5th finger (HP:0009237)1.85016201
68Pheochromocytoma (HP:0002666)1.84555629
69Carpal bone hypoplasia (HP:0001498)1.82915184
70Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.82894045
71Acute encephalopathy (HP:0006846)1.82024314
72Brushfield spots (HP:0001088)1.81038008
73Abnormality of the renal cortex (HP:0011035)1.80914259
74Intrahepatic cholestasis (HP:0001406)1.80006143
75Progressive macrocephaly (HP:0004481)1.79694303
76Neuroendocrine neoplasm (HP:0100634)1.78933820
77Intestinal atresia (HP:0011100)1.78921685
78Sclerocornea (HP:0000647)1.78472190
79Medulloblastoma (HP:0002885)1.77438170
80Choanal atresia (HP:0000453)1.77285910
81Oligohydramnios (HP:0001562)1.76838355
82Progressive inability to walk (HP:0002505)1.76143752
83Arteriovenous malformation (HP:0100026)1.75886735
84Abnormality of sulfur amino acid metabolism (HP:0004339)1.74419180
85Abnormality of macular pigmentation (HP:0008002)1.73320339
86Methylmalonic aciduria (HP:0012120)1.70174968
87Preaxial hand polydactyly (HP:0001177)1.69803774
88Absent thumb (HP:0009777)1.69569163
89Abnormality of the fovea (HP:0000493)1.68711223
90Postaxial foot polydactyly (HP:0001830)1.68007452
91Oculomotor apraxia (HP:0000657)1.65985814
92Acute necrotizing encephalopathy (HP:0006965)1.65777489
93Degeneration of anterior horn cells (HP:0002398)1.65098226
94Abnormality of the anterior horn cell (HP:0006802)1.65098226
95Horseshoe kidney (HP:0000085)1.62844655
96Cystic liver disease (HP:0006706)1.62786559
97Gonadotropin excess (HP:0000837)1.61803785
98Abnormality of aromatic amino acid family metabolism (HP:0004338)1.61757081
99Abnormality of the nasal septum (HP:0000419)1.58811897
100Abnormal mitochondria in muscle tissue (HP:0008316)1.58278240

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.24752399
2EIF2AK34.13170840
3PLK42.99756614
4TNIK2.87725231
5BUB12.69003605
6BRSK22.48107731
7FRK2.34526701
8WEE12.26489534
9TRIM282.18556956
10STK392.18003054
11PBK2.06826955
12TSSK62.02932012
13PNCK2.02842583
14SRPK11.99467025
15ERBB31.98612619
16FER1.95647524
17WNK31.93477987
18PLK31.86567376
19EIF2AK11.86057603
20NEK11.80627296
21ZAK1.76503396
22STK241.60594589
23NUAK11.52675965
24PLK21.47199669
25MKNK21.44458481
26TAF11.39767832
27VRK21.39670243
28TTK1.36955619
29SCYL21.32760056
30OXSR11.32475037
31PINK11.29342267
32BCR1.27961792
33PRKCI1.21531240
34BRSK11.20347087
35MAPKAPK31.19911231
36MKNK11.18864088
37BMPR1B1.15006462
38VRK11.12884544
39PLK11.11333226
40PDK21.10899347
41NME11.02951715
42CCNB10.99812025
43GRK10.99290803
44MAPK130.98182069
45MAP4K20.97770171
46PAK30.97682261
47STK100.96250916
48CASK0.94710096
49FLT30.89652640
50CSNK1G10.85782286
51CDC70.85360292
52ACVR1B0.84186562
53FGFR10.82742839
54EPHA40.78307883
55CSNK1G30.74499629
56ATR0.74203348
57EIF2AK20.73940781
58MAP3K120.73238696
59STK38L0.72110004
60BRD40.71062914
61STK30.70807934
62YES10.70148868
63TLK10.69870774
64CHEK20.69657146
65ERBB40.68487861
66CSNK1A1L0.67922336
67ADRBK20.67405722
68SIK30.65952880
69TESK20.64462781
70DYRK30.62451266
71MAP3K40.60552457
72NEK20.59471174
73AURKB0.55744405
74MAPKAPK50.54412460
75DAPK10.51744149
76MINK10.51283139
77CSNK1G20.50600335
78INSRR0.49603283
79ATM0.49302630
80CHEK10.48469070
81RPS6KB20.48291019
82FGFR20.45771080
83TGFBR10.41562715
84RPS6KA40.41184247
85PRKCE0.40496204
86AKT30.39375272
87ABL10.39078616
88OBSCN0.36668987
89ADRBK10.36363960
90CSNK2A10.32106051
91CSNK1A10.31841255
92CDK10.31826938
93AKT20.31289267
94IGF1R0.30841285
95WNK40.30456677
96MARK30.29950708
97NTRK30.29395442
98AURKA0.29297510
99CDK70.28767775
100CDK180.28113074

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.81570692
2Protein export_Homo sapiens_hsa030603.15238738
3Non-homologous end-joining_Homo sapiens_hsa034502.91718071
4Fanconi anemia pathway_Homo sapiens_hsa034602.87627575
5Homologous recombination_Homo sapiens_hsa034402.58335436
6Mismatch repair_Homo sapiens_hsa034302.52400340
7Steroid biosynthesis_Homo sapiens_hsa001002.48806285
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.32456957
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.31624447
10Fatty acid elongation_Homo sapiens_hsa000622.20629658
11Selenocompound metabolism_Homo sapiens_hsa004502.17618344
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.14218419
13Propanoate metabolism_Homo sapiens_hsa006402.08770872
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.06509055
15Caffeine metabolism_Homo sapiens_hsa002322.03575610
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83246352
17Basal transcription factors_Homo sapiens_hsa030221.76766706
18DNA replication_Homo sapiens_hsa030301.73787080
19Vitamin B6 metabolism_Homo sapiens_hsa007501.67619670
20RNA transport_Homo sapiens_hsa030131.67189702
21One carbon pool by folate_Homo sapiens_hsa006701.62548984
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.62443006
23Cell cycle_Homo sapiens_hsa041101.61674670
24Butanoate metabolism_Homo sapiens_hsa006501.61079273
25RNA polymerase_Homo sapiens_hsa030201.56206246
26Parkinsons disease_Homo sapiens_hsa050121.53605326
27RNA degradation_Homo sapiens_hsa030181.51526266
28Base excision repair_Homo sapiens_hsa034101.47821184
29Nucleotide excision repair_Homo sapiens_hsa034201.45912412
30Oxidative phosphorylation_Homo sapiens_hsa001901.45375446
31Peroxisome_Homo sapiens_hsa041461.36206852
32Folate biosynthesis_Homo sapiens_hsa007901.30630386
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.25859741
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.24657572
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20671931
36Glutathione metabolism_Homo sapiens_hsa004801.19811600
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.17131163
38Sulfur metabolism_Homo sapiens_hsa009201.16132664
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10305049
40p53 signaling pathway_Homo sapiens_hsa041151.09926713
41Oocyte meiosis_Homo sapiens_hsa041141.09381639
42Fatty acid metabolism_Homo sapiens_hsa012121.06551409
43mRNA surveillance pathway_Homo sapiens_hsa030151.05141428
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04488281
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01912303
46Linoleic acid metabolism_Homo sapiens_hsa005910.99921285
47Phototransduction_Homo sapiens_hsa047440.99689683
48Huntingtons disease_Homo sapiens_hsa050160.99218846
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98481512
50Spliceosome_Homo sapiens_hsa030400.98408911
51Fat digestion and absorption_Homo sapiens_hsa049750.98116667
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95402516
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94945311
54Lysine degradation_Homo sapiens_hsa003100.94636031
55Tryptophan metabolism_Homo sapiens_hsa003800.94405997
56Chemical carcinogenesis_Homo sapiens_hsa052040.92344360
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90444941
58Pyruvate metabolism_Homo sapiens_hsa006200.85783974
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.85578227
60Fatty acid degradation_Homo sapiens_hsa000710.84788814
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80143246
62N-Glycan biosynthesis_Homo sapiens_hsa005100.79296749
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78768325
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78609934
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78244500
66Pyrimidine metabolism_Homo sapiens_hsa002400.74589306
67Metabolic pathways_Homo sapiens_hsa011000.73081785
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.72932129
69Retinol metabolism_Homo sapiens_hsa008300.70614565
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70369728
71Carbon metabolism_Homo sapiens_hsa012000.69986428
72Alzheimers disease_Homo sapiens_hsa050100.67906933
73Purine metabolism_Homo sapiens_hsa002300.67687554
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67621831
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64549203
76Ether lipid metabolism_Homo sapiens_hsa005650.64495573
77Biosynthesis of amino acids_Homo sapiens_hsa012300.60907257
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55037295
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53581285
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.51831981
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50714431
82beta-Alanine metabolism_Homo sapiens_hsa004100.50542058
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44454405
84Tyrosine metabolism_Homo sapiens_hsa003500.43628852
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43415036
86Hedgehog signaling pathway_Homo sapiens_hsa043400.41695365
87Arginine and proline metabolism_Homo sapiens_hsa003300.41022871
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.40971126
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.40901952
90TGF-beta signaling pathway_Homo sapiens_hsa043500.40589166
91Arachidonic acid metabolism_Homo sapiens_hsa005900.39518896
92Collecting duct acid secretion_Homo sapiens_hsa049660.39399559
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39229592
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38673294
95Starch and sucrose metabolism_Homo sapiens_hsa005000.37306118
96Tight junction_Homo sapiens_hsa045300.35680155
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31865027
98Hippo signaling pathway_Homo sapiens_hsa043900.31124068
99Nitrogen metabolism_Homo sapiens_hsa009100.26168278
100Sphingolipid metabolism_Homo sapiens_hsa006000.25527185

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