ZNF826P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromatin remodeling at centromere (GO:0031055)4.43622761
2DNA double-strand break processing (GO:0000729)4.21103677
3CENP-A containing nucleosome assembly (GO:0034080)4.20848186
4negative regulation of DNA-dependent DNA replication (GO:2000104)4.13395755
5regulation of gene silencing by RNA (GO:0060966)3.73234204
6regulation of posttranscriptional gene silencing (GO:0060147)3.73234204
7regulation of gene silencing by miRNA (GO:0060964)3.73234204
8regulation of nuclear cell cycle DNA replication (GO:0033262)3.71142347
9histone exchange (GO:0043486)3.70120330
10replication fork processing (GO:0031297)3.53275239
11regulation of mitotic spindle checkpoint (GO:1903504)3.52814965
12regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.52814965
13negative regulation of translation, ncRNA-mediated (GO:0040033)3.51798623
14regulation of translation, ncRNA-mediated (GO:0045974)3.51798623
15negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.51798623
16DNA replication checkpoint (GO:0000076)3.45882478
17respiratory chain complex IV assembly (GO:0008535)3.45003277
18establishment of protein localization to mitochondrial membrane (GO:0090151)3.31476080
19water-soluble vitamin biosynthetic process (GO:0042364)3.27125118
20somatic diversification of immune receptors via somatic mutation (GO:0002566)3.19062135
21somatic hypermutation of immunoglobulin genes (GO:0016446)3.19062135
22DNA replication-independent nucleosome assembly (GO:0006336)3.15517955
23DNA replication-independent nucleosome organization (GO:0034724)3.15517955
24proteasome assembly (GO:0043248)3.11904618
25protein-cofactor linkage (GO:0018065)3.11478515
26regulation of centriole replication (GO:0046599)3.05930008
27nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.03601112
28recombinational repair (GO:0000725)3.02450067
29exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.01562011
30double-strand break repair via homologous recombination (GO:0000724)2.99148898
31synapsis (GO:0007129)2.97750349
32kinetochore assembly (GO:0051382)2.97499404
33protein neddylation (GO:0045116)2.95091283
34cytochrome complex assembly (GO:0017004)2.94110838
35regulation of helicase activity (GO:0051095)2.91070335
36behavioral response to nicotine (GO:0035095)2.90431536
37kinetochore organization (GO:0051383)2.90331928
38mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.85625331
39platelet dense granule organization (GO:0060155)2.84530630
40protein K6-linked ubiquitination (GO:0085020)2.83278637
41maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.82805762
42chaperone-mediated protein transport (GO:0072321)2.82623665
43establishment of integrated proviral latency (GO:0075713)2.82479643
44detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.79544122
45negative regulation of telomere maintenance (GO:0032205)2.73609633
46kidney morphogenesis (GO:0060993)2.72915871
47regulation of mesoderm development (GO:2000380)2.71030255
48resolution of meiotic recombination intermediates (GO:0000712)2.70380494
49DNA catabolic process, exonucleolytic (GO:0000738)2.69058925
50protein complex biogenesis (GO:0070271)2.68130144
51mitochondrial respiratory chain complex assembly (GO:0033108)2.64810508
52response to pheromone (GO:0019236)2.64100691
53histone mRNA metabolic process (GO:0008334)2.64011677
54DNA replication-dependent nucleosome organization (GO:0034723)2.63473287
55DNA replication-dependent nucleosome assembly (GO:0006335)2.63473287
56postreplication repair (GO:0006301)2.60751009
57tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.59549275
58RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.59549275
59presynaptic membrane assembly (GO:0097105)2.59308386
60negative regulation of DNA recombination (GO:0045910)2.59292403
61cullin deneddylation (GO:0010388)2.59277357
62DNA damage response, detection of DNA damage (GO:0042769)2.58103635
63centriole replication (GO:0007099)2.58102586
64reciprocal DNA recombination (GO:0035825)2.57932487
65reciprocal meiotic recombination (GO:0007131)2.57932487
66mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.57187924
67telomere maintenance via telomerase (GO:0007004)2.56365478
68DNA deamination (GO:0045006)2.55748958
69mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.55027003
70mitochondrial respiratory chain complex I assembly (GO:0032981)2.55027003
71NADH dehydrogenase complex assembly (GO:0010257)2.55027003
72ATP synthesis coupled proton transport (GO:0015986)2.54943171
73energy coupled proton transport, down electrochemical gradient (GO:0015985)2.54943171
74otic vesicle formation (GO:0030916)2.54795777
75L-fucose catabolic process (GO:0042355)2.54642476
76fucose catabolic process (GO:0019317)2.54642476
77L-fucose metabolic process (GO:0042354)2.54642476
78termination of RNA polymerase III transcription (GO:0006386)2.54389119
79transcription elongation from RNA polymerase III promoter (GO:0006385)2.54389119
80regulation of DNA endoreduplication (GO:0032875)2.53749841
81pseudouridine synthesis (GO:0001522)2.53689217
82DNA ligation (GO:0006266)2.50871896
83regulation of telomere maintenance (GO:0032204)2.50802392
84nonmotile primary cilium assembly (GO:0035058)2.48725920
85L-serine metabolic process (GO:0006563)2.46724805
86protein deneddylation (GO:0000338)2.43149972
87epithelial cilium movement (GO:0003351)2.42799684
88neural tube formation (GO:0001841)2.42635038
89somite rostral/caudal axis specification (GO:0032525)2.42628715
90somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.42467248
91somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.42467248
92isotype switching (GO:0045190)2.42467248
93intraciliary transport (GO:0042073)2.41559364
94DNA strand renaturation (GO:0000733)2.41108899
95negative regulation of mitotic sister chromatid separation (GO:2000816)2.38029311
96negative regulation of sister chromatid segregation (GO:0033046)2.38029311
97negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.38029311
98negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.38029311
99negative regulation of mitotic sister chromatid segregation (GO:0033048)2.38029311
100mitotic G2/M transition checkpoint (GO:0044818)2.38002055

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.53554213
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.12602607
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.95792560
4VDR_22108803_ChIP-Seq_LS180_Human2.83964626
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.71479861
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.71430540
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.59539198
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.56128832
9E2F7_22180533_ChIP-Seq_HELA_Human2.48685088
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.46906203
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.36462406
12FUS_26573619_Chip-Seq_HEK293_Human2.35289724
13EWS_26573619_Chip-Seq_HEK293_Human2.29686064
14IGF1R_20145208_ChIP-Seq_DFB_Human2.29575381
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.27680169
16P300_19829295_ChIP-Seq_ESCs_Human2.16857595
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.16852004
18GBX2_23144817_ChIP-Seq_PC3_Human2.16468129
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.15749654
20ELK1_19687146_ChIP-ChIP_HELA_Human2.10569716
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09922153
22POU5F1_16153702_ChIP-ChIP_HESCs_Human2.02447770
23TAF15_26573619_Chip-Seq_HEK293_Human1.99601633
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.96565543
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84944110
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83479214
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78206490
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.74759805
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68313962
30MYC_18940864_ChIP-ChIP_HL60_Human1.67798999
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64237261
32SOX2_16153702_ChIP-ChIP_HESCs_Human1.52165069
33VDR_23849224_ChIP-Seq_CD4+_Human1.51993869
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.49203356
35IRF1_19129219_ChIP-ChIP_H3396_Human1.46694415
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42070761
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.38855343
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38553080
39NANOG_16153702_ChIP-ChIP_HESCs_Human1.38089454
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37665385
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36201637
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.32287830
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30316274
44GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30085969
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.29670346
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29408773
47FOXP3_21729870_ChIP-Seq_TREG_Human1.29259016
48BCAT_22108803_ChIP-Seq_LS180_Human1.29201342
49FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.28843094
50POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27682066
51TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27682066
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27635460
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27452790
54SOX2_19829295_ChIP-Seq_ESCs_Human1.24533975
55NANOG_19829295_ChIP-Seq_ESCs_Human1.24533975
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.24459431
57ER_23166858_ChIP-Seq_MCF-7_Human1.23540587
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23159644
59SMAD4_21799915_ChIP-Seq_A2780_Human1.19356171
60NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.18327436
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17739293
62KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17546303
63JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.16802196
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.16751030
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16603630
66CBP_20019798_ChIP-Seq_JUKART_Human1.16603630
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16269461
68TCF4_22108803_ChIP-Seq_LS180_Human1.16219717
69NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15824617
70KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.15252699
71RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14810943
72TP53_22573176_ChIP-Seq_HFKS_Human1.14682459
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13962942
74SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13597902
75EZH2_22144423_ChIP-Seq_EOC_Human1.12332041
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12100751
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.12037817
78TP63_19390658_ChIP-ChIP_HaCaT_Human1.08922401
79AR_25329375_ChIP-Seq_VCAP_Human1.06470166
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06192524
81RUNX2_22187159_ChIP-Seq_PCA_Human1.06017352
82STAT3_23295773_ChIP-Seq_U87_Human1.05852372
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05453942
84FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04693618
85FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03904530
86FOXA1_25329375_ChIP-Seq_VCAP_Human1.03904530
87SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03516545
88SMAD4_21741376_ChIP-Seq_EPCs_Human1.01661556
89TCF4_23295773_ChIP-Seq_U87_Human1.00619815
90BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00603592
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99120392
92MYC_18555785_ChIP-Seq_MESCs_Mouse0.99034155
93NANOG_18555785_Chip-Seq_ESCs_Mouse0.98684944
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98053340
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97042802
96FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95744720
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95567379
98NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95083342
99RNF2_27304074_Chip-Seq_NSC_Mouse0.94311331
100SRF_21415370_ChIP-Seq_HL-1_Mouse0.94037283

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.72189899
2MP0008877_abnormal_DNA_methylation3.63722050
3MP0002102_abnormal_ear_morphology2.95170413
4MP0003136_yellow_coat_color2.91778316
5MP0003890_abnormal_embryonic-extraembry2.82568910
6MP0002254_reproductive_system_inflammat2.65301339
7MP0008058_abnormal_DNA_repair2.48039176
8MP0010094_abnormal_chromosome_stability2.24366221
9MP0003195_calcinosis2.13077295
10MP0003787_abnormal_imprinting2.09977354
11MP0001293_anophthalmia2.02835417
12MP0006072_abnormal_retinal_apoptosis2.00451969
13MP0002938_white_spotting1.99822238
14MP0004133_heterotaxia1.96789784
15MP0003941_abnormal_skin_development1.89085907
16MP0008057_abnormal_DNA_replication1.87389371
17MP0003718_maternal_effect1.82110860
18MP0003693_abnormal_embryo_hatching1.81996545
19MP0003880_abnormal_central_pattern1.73911713
20MP0005551_abnormal_eye_electrophysiolog1.72141787
21MP0003121_genomic_imprinting1.67081967
22MP0001485_abnormal_pinna_reflex1.65948484
23MP0001529_abnormal_vocalization1.64102866
24MP0003119_abnormal_digestive_system1.62173719
25MP0003937_abnormal_limbs/digits/tail_de1.60796300
26MP0005084_abnormal_gallbladder_morpholo1.60050066
27MP0002736_abnormal_nociception_after1.59230702
28MP0003567_abnormal_fetal_cardiomyocyte1.57849432
29MP0000631_abnormal_neuroendocrine_gland1.52045061
30MP0004957_abnormal_blastocyst_morpholog1.48655970
31MP0004147_increased_porphyrin_level1.48487914
32MP0001188_hyperpigmentation1.42061291
33MP0005253_abnormal_eye_physiology1.41874067
34MP0002653_abnormal_ependyma_morphology1.41628888
35MP0002837_dystrophic_cardiac_calcinosis1.41536345
36MP0002638_abnormal_pupillary_reflex1.40778177
37MP0001984_abnormal_olfaction1.40394727
38MP0008789_abnormal_olfactory_epithelium1.39470545
39MP0008995_early_reproductive_senescence1.37016168
40MP0001286_abnormal_eye_development1.36590873
41MP0000372_irregular_coat_pigmentation1.34310264
42MP0003122_maternal_imprinting1.30463769
43MP0001968_abnormal_touch/_nociception1.30420449
44MP0000049_abnormal_middle_ear1.28434760
45MP0003111_abnormal_nucleus_morphology1.28224432
46MP0002277_abnormal_respiratory_mucosa1.28129384
47MP0009046_muscle_twitch1.23155055
48MP0003878_abnormal_ear_physiology1.20896076
49MP0005377_hearing/vestibular/ear_phenot1.20896076
50MP0002751_abnormal_autonomic_nervous1.20731962
51MP0000647_abnormal_sebaceous_gland1.18673627
52MP0005499_abnormal_olfactory_system1.18355973
53MP0005394_taste/olfaction_phenotype1.18355973
54MP0004142_abnormal_muscle_tone1.18114293
55MP0006276_abnormal_autonomic_nervous1.17547100
56MP0003786_premature_aging1.13151965
57MP0003077_abnormal_cell_cycle1.12691427
58MP0008932_abnormal_embryonic_tissue1.12279956
59MP0002233_abnormal_nose_morphology1.10951956
60MP0008872_abnormal_physiological_respon1.09679306
61MP0004885_abnormal_endolymph1.07969792
62MP0009697_abnormal_copulation1.07331461
63MP0001486_abnormal_startle_reflex1.05831241
64MP0003938_abnormal_ear_development1.05205379
65MP0003011_delayed_dark_adaptation1.04342441
66MP0010030_abnormal_orbit_morphology1.03112691
67MP0002272_abnormal_nervous_system0.99703245
68MP0008007_abnormal_cellular_replicative0.98930603
69MP0009745_abnormal_behavioral_response0.97332994
70MP0002163_abnormal_gland_morphology0.96409211
71MP0002210_abnormal_sex_determination0.96156001
72MP0000778_abnormal_nervous_system0.95320563
73MP0005195_abnormal_posterior_eye0.94402156
74MP0000516_abnormal_urinary_system0.94331958
75MP0005367_renal/urinary_system_phenotyp0.94331958
76MP0000427_abnormal_hair_cycle0.94306411
77MP0001986_abnormal_taste_sensitivity0.93632323
78MP0001929_abnormal_gametogenesis0.93466450
79MP0002697_abnormal_eye_size0.92642694
80MP0005391_vision/eye_phenotype0.91191382
81MP0002160_abnormal_reproductive_system0.87733099
82MP0004215_abnormal_myocardial_fiber0.87726352
83MP0005645_abnormal_hypothalamus_physiol0.87073369
84MP0002138_abnormal_hepatobiliary_system0.86251294
85MP0002084_abnormal_developmental_patter0.86190558
86MP0006035_abnormal_mitochondrial_morpho0.85634733
87MP0001145_abnormal_male_reproductive0.84905237
88MP0000653_abnormal_sex_gland0.84707117
89MP0002557_abnormal_social/conspecific_i0.82501474
90MP0003137_abnormal_impulse_conducting0.82491390
91MP0002735_abnormal_chemical_nociception0.82224923
92MP0002752_abnormal_somatic_nervous0.81047205
93MP0005379_endocrine/exocrine_gland_phen0.80308388
94MP0003698_abnormal_male_reproductive0.80036479
95MP0000026_abnormal_inner_ear0.78780341
96MP0003755_abnormal_palate_morphology0.78068690
97MP0002111_abnormal_tail_morphology0.77498208
98MP0003861_abnormal_nervous_system0.77251319
99MP0009672_abnormal_birth_weight0.76958208
100MP0002234_abnormal_pharynx_morphology0.75872612

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)3.50940657
2Pancreatic cysts (HP:0001737)3.45130776
3Colon cancer (HP:0003003)3.42789341
4Septo-optic dysplasia (HP:0100842)3.42608078
5Pancreatic fibrosis (HP:0100732)3.16828627
6True hermaphroditism (HP:0010459)3.05579931
7Molar tooth sign on MRI (HP:0002419)3.03334022
8Abnormality of midbrain morphology (HP:0002418)3.03334022
9Nephronophthisis (HP:0000090)2.78861036
10Meckel diverticulum (HP:0002245)2.74574862
11Intestinal atresia (HP:0011100)2.68356096
12Abnormality of the ileum (HP:0001549)2.67529863
13Chromosomal breakage induced by crosslinking agents (HP:0003221)2.65906525
14Aplasia/Hypoplasia of the uvula (HP:0010293)2.64830966
15Pendular nystagmus (HP:0012043)2.63753618
16Abolished electroretinogram (ERG) (HP:0000550)2.52196977
17Medial flaring of the eyebrow (HP:0010747)2.47051476
18Chromsome breakage (HP:0040012)2.46809158
19Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.46491540
20Optic nerve hypoplasia (HP:0000609)2.42627770
21Abnormality of chromosome stability (HP:0003220)2.42534945
22Birth length less than 3rd percentile (HP:0003561)2.38524090
23Hyperglycinemia (HP:0002154)2.36618616
24Acute necrotizing encephalopathy (HP:0006965)2.35718717
25Congenital stationary night blindness (HP:0007642)2.34117770
26Genital tract atresia (HP:0001827)2.32822320
27Methylmalonic acidemia (HP:0002912)2.31644025
28Bilateral microphthalmos (HP:0007633)2.28291364
29Acute encephalopathy (HP:0006846)2.27130626
30Abnormality of the renal medulla (HP:0100957)2.26908853
31Vaginal atresia (HP:0000148)2.26749614
32Stenosis of the external auditory canal (HP:0000402)2.22539471
33Absent septum pellucidum (HP:0001331)2.21686481
34Anophthalmia (HP:0000528)2.19633846
35Increased hepatocellular lipid droplets (HP:0006565)2.15419401
36Gastrointestinal atresia (HP:0002589)2.13983726
37Mitochondrial inheritance (HP:0001427)2.10219527
38Congenital primary aphakia (HP:0007707)2.09896373
39Increased CSF lactate (HP:0002490)2.09206211
40Aplasia/Hypoplasia of the tongue (HP:0010295)2.07569519
41Gait imbalance (HP:0002141)2.07052253
42Progressive macrocephaly (HP:0004481)2.04011017
43Anencephaly (HP:0002323)2.03302516
44Chronic hepatic failure (HP:0100626)2.02910403
45Abnormal lung lobation (HP:0002101)1.99499816
463-Methylglutaconic aciduria (HP:0003535)1.98887231
47Sclerocornea (HP:0000647)1.98877662
48Hyperglycinuria (HP:0003108)1.98759791
49Triphalangeal thumb (HP:0001199)1.98514985
50Hypothermia (HP:0002045)1.97731972
51Lipid accumulation in hepatocytes (HP:0006561)1.96890954
52Abnormality of the septum pellucidum (HP:0007375)1.96739211
53Abnormal biliary tract physiology (HP:0012439)1.95997569
54Bile duct proliferation (HP:0001408)1.95997569
55Inability to walk (HP:0002540)1.93022088
56Abnormality of the preputium (HP:0100587)1.92480004
57Abnormality of serum amino acid levels (HP:0003112)1.90648120
58Abnormality of the duodenum (HP:0002246)1.90201623
59Progressive inability to walk (HP:0002505)1.89456974
60Methylmalonic aciduria (HP:0012120)1.89249751
61Esophageal atresia (HP:0002032)1.89226877
62Abnormality of the renal cortex (HP:0011035)1.88910802
63Aplasia/Hypoplasia of the tibia (HP:0005772)1.88045015
64Abnormality of alanine metabolism (HP:0010916)1.87685455
65Hyperalaninemia (HP:0003348)1.87685455
66Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87685455
67Nephrogenic diabetes insipidus (HP:0009806)1.85534111
68Aqueductal stenosis (HP:0002410)1.85478459
69Preaxial hand polydactyly (HP:0001177)1.85467604
70Hypoplasia of the pons (HP:0012110)1.83876050
71Cystic liver disease (HP:0006706)1.83457079
72Aplasia involving forearm bones (HP:0009822)1.82874155
73Absent forearm bone (HP:0003953)1.82874155
74Absent radius (HP:0003974)1.82853418
75Median cleft lip (HP:0000161)1.82190853
76Abnormal mitochondria in muscle tissue (HP:0008316)1.81818692
77Small hand (HP:0200055)1.79961555
78Dandy-Walker malformation (HP:0001305)1.79678997
79Abnormality of glycine metabolism (HP:0010895)1.79565781
80Abnormality of serine family amino acid metabolism (HP:0010894)1.79565781
81Ectopic kidney (HP:0000086)1.79185523
82Sloping forehead (HP:0000340)1.79043590
83Oligodactyly (hands) (HP:0001180)1.78558859
84Volvulus (HP:0002580)1.78536169
85Abnormality of the pons (HP:0007361)1.78221245
86Supernumerary spleens (HP:0009799)1.77213725
87Postaxial foot polydactyly (HP:0001830)1.77165333
88Neoplasm of the adrenal cortex (HP:0100641)1.76390698
89Small intestinal stenosis (HP:0012848)1.75125923
90Duodenal stenosis (HP:0100867)1.75125923
91Thyroid-stimulating hormone excess (HP:0002925)1.74694864
92Reticulocytopenia (HP:0001896)1.74474605
93Attenuation of retinal blood vessels (HP:0007843)1.74418948
94Hepatocellular necrosis (HP:0001404)1.72475827
95Male pseudohermaphroditism (HP:0000037)1.72149259
96Congenital, generalized hypertrichosis (HP:0004540)1.71906292
97Bifid tongue (HP:0010297)1.71606523
98Absent thumb (HP:0009777)1.71367879
99Postaxial hand polydactyly (HP:0001162)1.71237263
100Clubbing of toes (HP:0100760)1.70148452

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.19194741
2FRK3.12233465
3WNK33.07935984
4MAP4K22.95326594
5TNIK2.74178912
6TRIM282.59302018
7BMPR1B2.41821703
8CDC72.41703034
9MKNK22.38716091
10NUAK12.15693273
11VRK22.07629467
12GRK12.01535444
13MST41.95701166
14ACVR1B1.93917709
15PLK31.93615301
16PLK41.89039842
17CASK1.88740985
18MKNK11.86785963
19TSSK61.78831205
20BUB11.78289968
21VRK11.77860315
22ADRBK21.75114687
23SRPK11.71675915
24TTK1.71169441
25TAF11.60156724
26PBK1.48969784
27DYRK21.47966307
28PNCK1.46125973
29MAP3K41.45378417
30WEE11.44441225
31OXSR11.41044776
32INSRR1.40102719
33CDK191.38695400
34STK38L1.38043694
35PINK11.35116693
36BCR1.30598732
37MAPK131.29254315
38NLK1.24570697
39BRSK21.17892945
40NEK11.17070662
41PLK11.13368319
42STK31.08139741
43EIF2AK31.05705957
44FGFR21.03643724
45STK161.03281273
46TLK11.00852589
47CSNK1G10.99440775
48PLK20.98676125
49STK390.93615013
50TGFBR10.93307757
51WNK40.89333455
52NME10.85299634
53PRKCG0.83375341
54CHEK20.82362752
55PRKCE0.82146859
56DYRK30.81350314
57ATR0.80753276
58MAP2K70.80323509
59CSNK1G20.77477339
60PASK0.73931745
61PDK20.72279356
62PAK30.69735086
63CSNK1G30.69530262
64NEK20.66747112
65ATM0.65223038
66TIE10.64177957
67ERBB40.63285961
68BCKDK0.60520812
69CSNK1A1L0.51470768
70LATS10.50650201
71AURKB0.49199466
72EIF2AK20.48606607
73FGFR10.44960799
74PKN10.44200130
75DAPK20.43784265
76ADRBK10.43671216
77TAOK30.41609153
78CSNK1A10.39039525
79MINK10.38861633
80CSNK2A10.38856888
81PIK3CA0.38848359
82CSNK1E0.38202092
83MARK10.35743277
84CDK30.35425028
85PRKDC0.34801281
86OBSCN0.33818578
87CSNK1D0.33056579
88EPHA40.32664567
89CAMK2A0.32338427
90RPS6KA50.31554972
91CHEK10.31142969
92STK110.31075118
93ERBB30.30879940
94CSNK2A20.29725789
95STK40.29210627
96PRKACB0.29071390
97PRKG10.28903624
98NTRK20.27206246
99TEC0.26946007
100DYRK1A0.26511000

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034402.94375416
2Protein export_Homo sapiens_hsa030602.74994242
3Mismatch repair_Homo sapiens_hsa034302.56438716
4Oxidative phosphorylation_Homo sapiens_hsa001902.45137094
5RNA polymerase_Homo sapiens_hsa030202.44960976
6Fanconi anemia pathway_Homo sapiens_hsa034602.40934546
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.34366321
8Proteasome_Homo sapiens_hsa030502.30452501
9Basal transcription factors_Homo sapiens_hsa030222.26071287
10Non-homologous end-joining_Homo sapiens_hsa034502.21395445
11DNA replication_Homo sapiens_hsa030302.09093629
12Selenocompound metabolism_Homo sapiens_hsa004502.05548583
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.05363264
14Phototransduction_Homo sapiens_hsa047442.01447645
15Parkinsons disease_Homo sapiens_hsa050121.99537191
16Propanoate metabolism_Homo sapiens_hsa006401.94891085
17RNA degradation_Homo sapiens_hsa030181.86739432
18Butanoate metabolism_Homo sapiens_hsa006501.82826052
19One carbon pool by folate_Homo sapiens_hsa006701.77102894
20Ribosome_Homo sapiens_hsa030101.68169088
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.67795606
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.58014985
23Nitrogen metabolism_Homo sapiens_hsa009101.57991702
24RNA transport_Homo sapiens_hsa030131.55184430
25Huntingtons disease_Homo sapiens_hsa050161.54913043
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.45876714
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.45243691
28Spliceosome_Homo sapiens_hsa030401.45213579
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.42096241
30Nicotine addiction_Homo sapiens_hsa050331.39117366
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.36689191
32Nucleotide excision repair_Homo sapiens_hsa034201.35338688
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.33557868
34Base excision repair_Homo sapiens_hsa034101.31089306
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.29244016
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.25256505
37Steroid biosynthesis_Homo sapiens_hsa001001.24353664
38Linoleic acid metabolism_Homo sapiens_hsa005911.20816912
39Vitamin B6 metabolism_Homo sapiens_hsa007501.19741814
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.18908624
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.18884789
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12984323
43Alzheimers disease_Homo sapiens_hsa050101.12973648
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12029878
45Tryptophan metabolism_Homo sapiens_hsa003801.09005881
46Purine metabolism_Homo sapiens_hsa002301.08572472
47Cell cycle_Homo sapiens_hsa041101.08527278
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06572436
49Pyrimidine metabolism_Homo sapiens_hsa002401.03953872
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.02796424
51Ether lipid metabolism_Homo sapiens_hsa005650.99052447
52Vitamin digestion and absorption_Homo sapiens_hsa049770.98333613
53Cardiac muscle contraction_Homo sapiens_hsa042600.96757369
54Peroxisome_Homo sapiens_hsa041460.95074064
55Taste transduction_Homo sapiens_hsa047420.94916351
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.94451462
57Basal cell carcinoma_Homo sapiens_hsa052170.92529209
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91656150
59Caffeine metabolism_Homo sapiens_hsa002320.90298988
60Retinol metabolism_Homo sapiens_hsa008300.89428571
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87590242
62Pyruvate metabolism_Homo sapiens_hsa006200.85108370
63beta-Alanine metabolism_Homo sapiens_hsa004100.83629283
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82786696
65Fatty acid elongation_Homo sapiens_hsa000620.81634724
66Olfactory transduction_Homo sapiens_hsa047400.78915948
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78644070
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77933523
69Hedgehog signaling pathway_Homo sapiens_hsa043400.73515783
70Chemical carcinogenesis_Homo sapiens_hsa052040.71607311
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.69272194
72Metabolic pathways_Homo sapiens_hsa011000.68727460
73TGF-beta signaling pathway_Homo sapiens_hsa043500.68033243
74mRNA surveillance pathway_Homo sapiens_hsa030150.67829738
75Folate biosynthesis_Homo sapiens_hsa007900.66240642
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64880984
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63108024
78Oocyte meiosis_Homo sapiens_hsa041140.61902942
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61228764
80Hippo signaling pathway_Homo sapiens_hsa043900.61126816
81p53 signaling pathway_Homo sapiens_hsa041150.60358209
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60204696
83Glutathione metabolism_Homo sapiens_hsa004800.58511234
84Regulation of autophagy_Homo sapiens_hsa041400.56557238
85Fat digestion and absorption_Homo sapiens_hsa049750.54256240
86GABAergic synapse_Homo sapiens_hsa047270.53031122
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52183589
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51616052
89Morphine addiction_Homo sapiens_hsa050320.46500400
90Fatty acid degradation_Homo sapiens_hsa000710.44553561
91Wnt signaling pathway_Homo sapiens_hsa043100.42877253
92Arachidonic acid metabolism_Homo sapiens_hsa005900.40810786
93Serotonergic synapse_Homo sapiens_hsa047260.39968191
94Insulin secretion_Homo sapiens_hsa049110.35332841
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34360491
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33743369
97Circadian entrainment_Homo sapiens_hsa047130.33545936
98Tight junction_Homo sapiens_hsa045300.32246851
99Fatty acid metabolism_Homo sapiens_hsa012120.31478105
100Collecting duct acid secretion_Homo sapiens_hsa049660.29818032

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