ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	presynaptic membrane assembly (GO:0097105)	4.39341951
2	limb bud formation (GO:0060174)	4.27530238
3	presynaptic membrane organization (GO:0097090)	3.91192373
4	urinary tract smooth muscle contraction (GO:0014848)	3.61890445
5	dendritic spine morphogenesis (GO:0060997)	3.54171246
6	tachykinin receptor signaling pathway (GO:0007217)	3.51551200
7	kidney morphogenesis (GO:0060993)	3.46198761
8	axonal fasciculation (GO:0007413)	3.43752340
9	positive regulation of action potential (GO:0045760)	3.43694116
10	righting reflex (GO:0060013)	3.43011293
11	neuron recognition (GO:0008038)	3.32464270
12	cerebral cortex radially oriented cell migration (GO:0021799)	3.29368714
13	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.27526310
14	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.27526310
15	regulation of translation, ncRNA-mediated (GO:0045974)	3.27526310
16	retinal ganglion cell axon guidance (GO:0031290)	3.23353169
17	pyrimidine nucleobase catabolic process (GO:0006208)	3.23113862
18	response to auditory stimulus (GO:0010996)	3.22998622
19	negative regulation of axon guidance (GO:1902668)	3.19722291
20	positive regulation of vascular permeability (GO:0043117)	3.15856571
21	central nervous system projection neuron axonogenesis (GO:0021952)	3.14227392
22	postsynaptic membrane organization (GO:0001941)	3.10153639
23	regulation of axon guidance (GO:1902667)	3.08044666
24	regulation of action potential (GO:0098900)	3.07577222
25	axon extension involved in axon guidance (GO:0048846)	3.03072207
26	neuron projection extension involved in neuron projection guidance (GO:1902284)	3.03072207
27	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.01277128
28	hindbrain development (GO:0030902)	3.00333339
29	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.99752574
30	positive regulation of synaptic transmission, GABAergic (GO:0032230)	2.98697124
31	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.95359028
32	regulation of axon extension involved in axon guidance (GO:0048841)	2.91869691
33	vocalization behavior (GO:0071625)	2.89637437
34	establishment of nucleus localization (GO:0040023)	2.89224236
35	neuron cell-cell adhesion (GO:0007158)	2.86196000
36	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.85784085
37	spinal cord development (GO:0021510)	2.82178336
38	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.81787818
39	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.80505046
40	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	2.79731115
41	protein localization to synapse (GO:0035418)	2.78226006
42	glutamate receptor signaling pathway (GO:0007215)	2.77304923
43	regulation of synaptic transmission, GABAergic (GO:0032228)	2.76963864
44	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.73883437
45	negative regulation of axon extension (GO:0030517)	2.68480828
46	central nervous system neuron axonogenesis (GO:0021955)	2.68424288
47	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.65963407
48	nucleobase catabolic process (GO:0046113)	2.64132683
49	artery development (GO:0060840)	2.61699289
50	reflex (GO:0060004)	2.61025770
51	startle response (GO:0001964)	2.59616662
52	behavioral response to nicotine (GO:0035095)	2.59599372
53	negative regulation of astrocyte differentiation (GO:0048712)	2.58686653
54	neural tube formation (GO:0001841)	2.57046599
55	nonmotile primary cilium assembly (GO:0035058)	2.55796268
56	limb development (GO:0060173)	2.55542349
57	appendage development (GO:0048736)	2.55542349
58	behavioral response to ethanol (GO:0048149)	2.53647995
59	olfactory bulb development (GO:0021772)	2.50278610
60	renal tubule morphogenesis (GO:0061333)	2.49724711
61	nephron tubule morphogenesis (GO:0072078)	2.48238340
62	nephron epithelium morphogenesis (GO:0072088)	2.48238340
63	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.46763346
64	somite development (GO:0061053)	2.44289856
65	mechanosensory behavior (GO:0007638)	2.42074216
66	cell migration in hindbrain (GO:0021535)	2.42037669
67	seminiferous tubule development (GO:0072520)	2.40580805
68	intraciliary transport (GO:0042073)	2.40023657
69	cerebral cortex cell migration (GO:0021795)	2.39963391
70	epithelial cilium movement (GO:0003351)	2.39805560
71	negative chemotaxis (GO:0050919)	2.39544579
72	smooth muscle contraction (GO:0006939)	2.37966308
73	neuronal action potential propagation (GO:0019227)	2.37806314
74	retina layer formation (GO:0010842)	2.37305820
75	membrane depolarization during action potential (GO:0086010)	2.36312748
76	axon extension (GO:0048675)	2.35533033
77	tongue development (GO:0043586)	2.35510206
78	regulation of timing of cell differentiation (GO:0048505)	2.34794489
79	negative regulation of osteoblast proliferation (GO:0033689)	2.34457267
80	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.34399036
81	neuronal stem cell maintenance (GO:0097150)	2.33351539
82	transmission of nerve impulse (GO:0019226)	2.32846178
83	sympathetic nervous system development (GO:0048485)	2.32825893
84	aggressive behavior (GO:0002118)	2.32503756
85	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.31539213
86	negative regulation of dendrite development (GO:2000171)	2.31355245
87	auditory behavior (GO:0031223)	2.30298683
88	forebrain neuron differentiation (GO:0021879)	2.28204150
89	regulation of synapse assembly (GO:0051963)	2.28063461
90	positive regulation of synapse assembly (GO:0051965)	2.27235954
91	ganglion development (GO:0061548)	2.26167224
92	regulation of male gonad development (GO:2000018)	2.24912952
93	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.24053385
94	regulation of collateral sprouting (GO:0048670)	2.23870399
95	positive regulation of cardiac muscle cell differentiation (GO:2000727)	2.23302075
96	lateral sprouting from an epithelium (GO:0060601)	2.21727869
97	synaptic transmission, glutamatergic (GO:0035249)	2.21212789
98	cilium movement (GO:0003341)	2.21076209
99	retinal cone cell development (GO:0046549)	2.18333472
100	behavioral defense response (GO:0002209)	2.17667027

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.78583490
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.57340532
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.49014944
4	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.83118770
5	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.69515950
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.65295329
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.44051503
8	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.40116517
9	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.30368590
10	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.19234539
11	FUS_26573619_Chip-Seq_HEK293_Human	2.18925547
12	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	2.16107668
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.13822470
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.12086704
15	TAF15_26573619_Chip-Seq_HEK293_Human	2.06580806
16	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.05364807
17	ZNF274_21170338_ChIP-Seq_K562_Hela	2.05265977
18	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.03461987
19	VDR_22108803_ChIP-Seq_LS180_Human	2.03184428
20	P300_19829295_ChIP-Seq_ESCs_Human	1.98132496
21	AR_21572438_ChIP-Seq_LNCaP_Human	1.92313208
22	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.90760992
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.89645698
24	IGF1R_20145208_ChIP-Seq_DFB_Human	1.87504425
25	SMAD4_21799915_ChIP-Seq_A2780_Human	1.84721868
26	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.84433033
27	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.73521527
28	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.69112622
29	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.68077252
30	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.63879327
31	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.63549235
32	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.63549235
33	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.58061917
34	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.57039812
35	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.56594164
36	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.56299014
37	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.56076785
38	STAT3_23295773_ChIP-Seq_U87_Human	1.55588723
39	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.54315309
40	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.52105152
41	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.51426364
42	EWS_26573619_Chip-Seq_HEK293_Human	1.51096089
43	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.51040203
44	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.49940801
45	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.48246466
46	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.47503638
47	AR_25329375_ChIP-Seq_VCAP_Human	1.47431737
48	RNF2_27304074_Chip-Seq_NSC_Mouse	1.45207064
49	REST_21632747_ChIP-Seq_MESCs_Mouse	1.44720110
50	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.43334510
51	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.41902511
52	BCAT_22108803_ChIP-Seq_LS180_Human	1.40240876
53	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.36535138
54	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.35892987
55	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.32772790
56	CBP_20019798_ChIP-Seq_JUKART_Human	1.32772790
57	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.32661871
58	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.32413118
59	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.31785701
60	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.30990103
61	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.30478764
62	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.30478764
63	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.30134742
64	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.29499484
65	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.28617529
66	TCF4_23295773_ChIP-Seq_U87_Human	1.27978732
67	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.27561075
68	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.27468720
69	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.27227811
70	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.27221036
71	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.24031676
72	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.23352449
73	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.22555832
74	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.21393831
75	ER_23166858_ChIP-Seq_MCF-7_Human	1.21253782
76	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.21220468
77	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.20560517
78	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.20414342
79	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.19072926
80	RUNX2_22187159_ChIP-Seq_PCA_Human	1.18450475
81	KDM2B_26808549_Chip-Seq_REH_Human	1.17923711
82	TP53_16413492_ChIP-PET_HCT116_Human	1.17631926
83	DROSHA_22980978_ChIP-Seq_HELA_Human	1.17244557
84	TP53_18474530_ChIP-ChIP_U2OS_Human	1.16425738
85	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.15922155
86	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.15556737
87	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.14902038
88	P53_22387025_ChIP-Seq_ESCs_Mouse	1.14385749
89	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.14121356
90	SOX9_26525672_Chip-Seq_HEART_Mouse	1.12400918
91	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12204360
92	RXR_22108803_ChIP-Seq_LS180_Human	1.11957495
93	YAP1_20516196_ChIP-Seq_MESCs_Mouse	1.10365868
94	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.09717634
95	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.09705392
96	TCF4_22108803_ChIP-Seq_LS180_Human	1.09566345
97	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.08479901
98	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.08029314
99	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.07917409
100	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.07162607

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002736_abnormal_nociception_after	2.44274830
2	MP0001529_abnormal_vocalization	2.42352702
3	MP0002735_abnormal_chemical_nociception	2.39915803
4	MP0003880_abnormal_central_pattern	2.27594979
5	MP0000569_abnormal_digit_pigmentation	2.26441113
6	MP0000778_abnormal_nervous_system	2.18523208
7	MP0004859_abnormal_synaptic_plasticity	2.17163206
8	MP0003136_yellow_coat_color	2.16344835
9	MP0001968_abnormal_touch/_nociception	2.11163226
10	MP0002938_white_spotting	2.07624444
11	MP0004270_analgesia	2.07548174
12	MP0002751_abnormal_autonomic_nervous	1.97106017
13	MP0003283_abnormal_digestive_organ	1.91894187
14	MP0002822_catalepsy	1.88506726
15	MP0002734_abnormal_mechanical_nocicepti	1.76853295
16	MP0000631_abnormal_neuroendocrine_gland	1.73761394
17	MP0003635_abnormal_synaptic_transmissio	1.67525907
18	MP0004885_abnormal_endolymph	1.60766666
19	MP0002572_abnormal_emotion/affect_behav	1.54659747
20	MP0005084_abnormal_gallbladder_morpholo	1.53231995
21	MP0003121_genomic_imprinting	1.52888611
22	MP0001984_abnormal_olfaction	1.52877615
23	MP0010386_abnormal_urinary_bladder	1.52877290
24	MP0005423_abnormal_somatic_nervous	1.50429375
25	MP0003122_maternal_imprinting	1.50336308
26	MP0004133_heterotaxia	1.49764142
27	MP0009745_abnormal_behavioral_response	1.49004348
28	MP0008877_abnormal_DNA_methylation	1.43754133
29	MP0002272_abnormal_nervous_system	1.42794691
30	MP0001299_abnormal_eye_distance/	1.40706444
31	MP0006292_abnormal_olfactory_placode	1.40556274
32	MP0002184_abnormal_innervation	1.39664386
33	MP0009780_abnormal_chondrocyte_physiolo	1.38672199
34	MP0002638_abnormal_pupillary_reflex	1.38329200
35	MP0005171_absent_coat_pigmentation	1.35706578
36	MP0001486_abnormal_startle_reflex	1.35454069
37	MP0006072_abnormal_retinal_apoptosis	1.35318712
38	MP0003787_abnormal_imprinting	1.34843760
39	MP0002063_abnormal_learning/memory/cond	1.32687092
40	MP0003890_abnormal_embryonic-extraembry	1.29278375
41	MP0002234_abnormal_pharynx_morphology	1.29140024
42	MP0008961_abnormal_basal_metabolism	1.28937692
43	MP0003937_abnormal_limbs/digits/tail_de	1.27386935
44	MP0000538_abnormal_urinary_bladder	1.27133260
45	MP0002909_abnormal_adrenal_gland	1.26855882
46	MP0005645_abnormal_hypothalamus_physiol	1.26125680
47	MP0003755_abnormal_palate_morphology	1.23862880
48	MP0005386_behavior/neurological_phenoty	1.23494828
49	MP0004924_abnormal_behavior	1.23494828
50	MP0005367_renal/urinary_system_phenotyp	1.23184328
51	MP0000516_abnormal_urinary_system	1.23184328
52	MP0000955_abnormal_spinal_cord	1.22355686
53	MP0005503_abnormal_tendon_morphology	1.22020156
54	MP0002653_abnormal_ependyma_morphology	1.21592829
55	MP0001970_abnormal_pain_threshold	1.21054351
56	MP0002067_abnormal_sensory_capabilities	1.20410535
57	MP0002233_abnormal_nose_morphology	1.20115277
58	MP0002557_abnormal_social/conspecific_i	1.17187281
59	MP0000534_abnormal_ureter_morphology	1.16523414
60	MP0003861_abnormal_nervous_system	1.14259124
61	MP0003119_abnormal_digestive_system	1.13778690
62	MP0009250_abnormal_appendicular_skeleto	1.12497468
63	MP0004145_abnormal_muscle_electrophysio	1.10498241
64	MP0005646_abnormal_pituitary_gland	1.09380047
65	MP0002928_abnormal_bile_duct	1.08271194
66	MP0008057_abnormal_DNA_replication	1.06106656
67	MP0005248_abnormal_Harderian_gland	1.05999189
68	MP0002882_abnormal_neuron_morphology	1.04087031
69	MP0002064_seizures	1.03712013
70	MP0005379_endocrine/exocrine_gland_phen	1.03019526
71	MP0004142_abnormal_muscle_tone	1.02997934
72	MP0006276_abnormal_autonomic_nervous	1.02997870
73	MP0000049_abnormal_middle_ear	1.00840485
74	MP0010030_abnormal_orbit_morphology	1.00342560
75	MP0000537_abnormal_urethra_morphology	0.99699836
76	MP0009046_muscle_twitch	0.99375058
77	MP0005551_abnormal_eye_electrophysiolog	0.98690615
78	MP0001485_abnormal_pinna_reflex	0.98370981
79	MP0000566_synostosis	0.98011325
80	MP0003935_abnormal_craniofacial_develop	0.97946723
81	MP0002752_abnormal_somatic_nervous	0.97621867
82	MP0002152_abnormal_brain_morphology	0.97164135
83	MP0004043_abnormal_pH_regulation	0.95839009
84	MP0002116_abnormal_craniofacial_bone	0.89772986
85	MP0001944_abnormal_pancreas_morphology	0.89612424
86	MP0000026_abnormal_inner_ear	0.89077785
87	MP0005187_abnormal_penis_morphology	0.88605149
88	MP0005253_abnormal_eye_physiology	0.87614114
89	MP0001270_distended_abdomen	0.87384060
90	MP0001293_anophthalmia	0.86751804
91	MP0000462_abnormal_digestive_system	0.84594905
92	MP0001286_abnormal_eye_development	0.84409907
93	MP0003942_abnormal_urinary_system	0.83742926
94	MP0001177_atelectasis	0.83472956
95	MP0002102_abnormal_ear_morphology	0.83441345
96	MP0008789_abnormal_olfactory_epithelium	0.81760574
97	MP0002733_abnormal_thermal_nociception	0.80780614
98	MP0003938_abnormal_ear_development	0.80393802
99	MP0001188_hyperpigmentation	0.80094188
100	MP0000432_abnormal_head_morphology	0.78962095

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the labia minora (HP:0012880)	3.58590687
2	Volvulus (HP:0002580)	2.84798801
3	Nephronophthisis (HP:0000090)	2.83351357
4	Hyperventilation (HP:0002883)	2.73817143
5	Hepatoblastoma (HP:0002884)	2.73806105
6	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.72677951
7	Neoplasm of the heart (HP:0100544)	2.67705168
8	Atonic seizures (HP:0010819)	2.58497749
9	Intestinal atresia (HP:0011100)	2.57826809
10	Abnormality of the ischium (HP:0003174)	2.57611885
11	Hypoplastic ischia (HP:0003175)	2.56960042
12	True hermaphroditism (HP:0010459)	2.55119637
13	Progressive cerebellar ataxia (HP:0002073)	2.54251763
14	Abnormality of the renal medulla (HP:0100957)	2.54069162
15	Medial flaring of the eyebrow (HP:0010747)	2.52561439
16	Gait imbalance (HP:0002141)	2.51207348
17	Short 4th metacarpal (HP:0010044)	2.47998828
18	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.47998828
19	Abnormality of midbrain morphology (HP:0002418)	2.45571821
20	Molar tooth sign on MRI (HP:0002419)	2.45571821
21	Pancreatic cysts (HP:0001737)	2.45222272
22	Febrile seizures (HP:0002373)	2.42757265
23	Drooling (HP:0002307)	2.39831625
24	Pancreatic fibrosis (HP:0100732)	2.38921756
25	Broad-based gait (HP:0002136)	2.37917229
26	Focal motor seizures (HP:0011153)	2.32767419
27	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.31769442
28	Septo-optic dysplasia (HP:0100842)	2.29828154
29	Overgrowth (HP:0001548)	2.27350262
30	Chronic hepatic failure (HP:0100626)	2.27013648
31	Aqueductal stenosis (HP:0002410)	2.26860288
32	Neonatal short-limb short stature (HP:0008921)	2.25942164
33	Genital tract atresia (HP:0001827)	2.19042583
34	Abnormality of the pubic bones (HP:0003172)	2.17956350
35	Vaginal atresia (HP:0000148)	2.16528747
36	Congenital primary aphakia (HP:0007707)	2.15816020
37	Long clavicles (HP:0000890)	2.14485509
38	Excessive salivation (HP:0003781)	2.12826973
39	Focal seizures (HP:0007359)	2.12336568
40	Abnormality of the 4th metacarpal (HP:0010012)	2.08216232
41	Hemiparesis (HP:0001269)	2.05933787
42	Postaxial hand polydactyly (HP:0001162)	2.03291246
43	Optic nerve hypoplasia (HP:0000609)	2.02485938
44	Abnormality of the renal cortex (HP:0011035)	2.02369000
45	Protruding tongue (HP:0010808)	2.01194640
46	Genetic anticipation (HP:0003743)	2.00996704
47	Anophthalmia (HP:0000528)	1.97575173
48	Short phalanx of the thumb (HP:0009660)	1.95226901
49	Short foot (HP:0001773)	1.94203910
50	Renal hypoplasia (HP:0000089)	1.93253533
51	Tubular atrophy (HP:0000092)	1.91675012
52	Dialeptic seizures (HP:0011146)	1.91444503
53	Neoplasm of the oral cavity (HP:0100649)	1.91189335
54	Hypoplastic labia majora (HP:0000059)	1.88852173
55	Gastrointestinal atresia (HP:0002589)	1.88223009
56	Nephrogenic diabetes insipidus (HP:0009806)	1.86873419
57	Cystic liver disease (HP:0006706)	1.85852574
58	Megalencephaly (HP:0001355)	1.83371744
59	Cutaneous finger syndactyly (HP:0010554)	1.81475965
60	Abnormality of the antihelix (HP:0009738)	1.80523960
61	Hypothermia (HP:0002045)	1.80183904
62	Labial hypoplasia (HP:0000066)	1.79944669
63	Gaze-evoked nystagmus (HP:0000640)	1.76606238
64	Poor coordination (HP:0002370)	1.76368509
65	Narrow forehead (HP:0000341)	1.75926505
66	Morphological abnormality of the middle ear (HP:0008609)	1.74504029
67	Midline defect of the nose (HP:0004122)	1.73414573
68	Oligodactyly (hands) (HP:0001180)	1.72659506
69	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	1.71021934
70	Rib fusion (HP:0000902)	1.69941090
71	Renal dysplasia (HP:0000110)	1.68145181
72	Abnormality of the labia majora (HP:0012881)	1.66407719
73	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.65543600
74	Epileptiform EEG discharges (HP:0011182)	1.64070183
75	Vitreoretinal degeneration (HP:0000655)	1.63813618
76	Short 1st metacarpal (HP:0010034)	1.63557724
77	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	1.63557724
78	Esophageal atresia (HP:0002032)	1.63017220
79	EEG with generalized epileptiform discharges (HP:0011198)	1.62492177
80	Hypsarrhythmia (HP:0002521)	1.62031076
81	Exotropia (HP:0000577)	1.61428358
82	Bifid tongue (HP:0010297)	1.60692772
83	Widely spaced teeth (HP:0000687)	1.60594124
84	Micropenis (HP:0000054)	1.60120899
85	Hypoplastic female external genitalia (HP:0012815)	1.59592817
86	Anencephaly (HP:0002323)	1.58783269
87	Postaxial foot polydactyly (HP:0001830)	1.57915732
88	Broad foot (HP:0001769)	1.57129887
89	Blue irides (HP:0000635)	1.56653251
90	Sclerocornea (HP:0000647)	1.56025591
91	Alacrima (HP:0000522)	1.55465602
92	Abnormality of the diencephalon (HP:0010662)	1.55198406
93	Fibular hypoplasia (HP:0003038)	1.55179540
94	Decreased lacrimation (HP:0000633)	1.52904824
95	Highly arched eyebrow (HP:0002553)	1.51426465
96	Shallow orbits (HP:0000586)	1.50744338
97	Limited hip movement (HP:0008800)	1.48980559
98	Large for gestational age (HP:0001520)	1.48027048
99	Facial hemangioma (HP:0000329)	1.47139253
100	Abnormality of abdominal situs (HP:0011620)	1.47037001

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TNIK	3.97437660
2	MARK1	3.88275436
3	CASK	3.34878826
4	PNCK	3.30851875
5	FRK	3.25193694
6	NTRK2	2.82544378
7	BMPR1B	2.71508144
8	WNK3	2.43679096
9	MAPK13	2.31272798
10	MKNK2	2.26418639
11	CAMK1G	1.89284914
12	BCR	1.82527592
13	MAP4K2	1.76487970
14	TRIM28	1.70029540
15	FGFR2	1.65784979
16	MAP3K4	1.53669690
17	PHKG2	1.35029235
18	PHKG1	1.35029235
19	MKNK1	1.32948851
20	PINK1	1.30332556
21	NTRK3	1.30330902
22	MAPK15	1.30062680
23	SGK2	1.27451797
24	EPHA4	1.24111169
25	DYRK2	1.22032722
26	CAMK1D	1.20670198
27	NUAK1	1.19942900
28	TGFBR1	1.19623099
29	PAK3	1.18841339
30	EPHB2	1.16427440
31	ACVR1B	1.14851419
32	TAF1	1.12225714
33	LMTK2	1.03028918
34	SGK223	1.02256595
35	SGK494	1.02256595
36	STK3	1.02191950
37	LATS1	1.01360315
38	PRKCE	1.00340595
39	PRKCG	0.99644079
40	SIK2	0.96768905
41	CDK3	0.92282438
42	AKT3	0.92025511
43	VRK1	0.91376005
44	NLK	0.91151248
45	STK39	0.88131969
46	PLK3	0.87307134
47	ERBB3	0.86350682
48	STK38L	0.83773430
49	ROCK1	0.76748788
50	PLK2	0.76647363
51	MAP2K7	0.74981223
52	DMPK	0.74880356
53	UHMK1	0.74037334
54	FGFR1	0.72626879
55	WNK4	0.71963025
56	DAPK2	0.70105394
57	PASK	0.67425920
58	BRD4	0.64930704
59	DYRK1A	0.64850684
60	FLT3	0.61670491
61	PKN2	0.60226790
62	ROCK2	0.60192437
63	PLK4	0.59053818
64	CAMK2A	0.59026364
65	CSNK1G2	0.58358734
66	PRKCH	0.58277564
67	WNK1	0.58234402
68	STK11	0.58183876
69	PTK2B	0.57502850
70	MAP3K10	0.56244263
71	CSNK1G1	0.55901362
72	INSRR	0.54984412
73	PRKD3	0.52506498
74	GRK1	0.52353355
75	PRKCZ	0.51826335
76	CAMK1	0.49238443
77	EPHA3	0.49221336
78	PKN1	0.48975622
79	ZAK	0.48328280
80	YES1	0.48013052
81	PRKDC	0.46938437
82	CDK5	0.46559870
83	SGK1	0.46105066
84	EIF2AK3	0.45979976
85	WEE1	0.45666015
86	SGK3	0.45469977
87	OBSCN	0.43486103
88	CAMK2D	0.42683782
89	PTK2	0.41813566
90	GSK3A	0.41691428
91	CAMKK2	0.40951900
92	BRSK2	0.40589648
93	CAMK2B	0.40552025
94	MET	0.39366110
95	PRKG1	0.39261965
96	ATM	0.39155437
97	PRKAA1	0.38891774
98	CDC7	0.38304906
99	ERBB2	0.38130195
100	MINK1	0.38002259

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	2.70967138
2	Taste transduction_Homo sapiens_hsa04742	2.42192637
3	Glutamatergic synapse_Homo sapiens_hsa04724	2.33880440
4	Insulin secretion_Homo sapiens_hsa04911	2.25125395
5	Cocaine addiction_Homo sapiens_hsa05030	2.21668287
6	Amphetamine addiction_Homo sapiens_hsa05031	2.08598854
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.04739670
8	Circadian entrainment_Homo sapiens_hsa04713	2.02266235
9	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.95877113
10	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.86476116
11	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.84145376
12	Axon guidance_Homo sapiens_hsa04360	1.82365077
13	Basal cell carcinoma_Homo sapiens_hsa05217	1.78674531
14	GABAergic synapse_Homo sapiens_hsa04727	1.67313132
15	Dopaminergic synapse_Homo sapiens_hsa04728	1.60189201
16	Propanoate metabolism_Homo sapiens_hsa00640	1.59174517
17	Olfactory transduction_Homo sapiens_hsa04740	1.57828750
18	Morphine addiction_Homo sapiens_hsa05032	1.50152704
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.45743740
20	Cholinergic synapse_Homo sapiens_hsa04725	1.45062431
21	Salivary secretion_Homo sapiens_hsa04970	1.43390964
22	Calcium signaling pathway_Homo sapiens_hsa04020	1.40909495
23	Protein export_Homo sapiens_hsa03060	1.40848512
24	Butanoate metabolism_Homo sapiens_hsa00650	1.38756662
25	Hippo signaling pathway_Homo sapiens_hsa04390	1.37716754
26	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.35638761
27	Thyroid hormone synthesis_Homo sapiens_hsa04918	1.29286919
28	Melanogenesis_Homo sapiens_hsa04916	1.28028344
29	Phototransduction_Homo sapiens_hsa04744	1.27883827
30	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.26516507
31	Non-homologous end-joining_Homo sapiens_hsa03450	1.26502409
32	Circadian rhythm_Homo sapiens_hsa04710	1.24557649
33	Gap junction_Homo sapiens_hsa04540	1.24555076
34	Wnt signaling pathway_Homo sapiens_hsa04310	1.22135345
35	Serotonergic synapse_Homo sapiens_hsa04726	1.21786901
36	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.20243894
37	Renin secretion_Homo sapiens_hsa04924	1.20118980
38	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.19681007
39	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.18137838
40	cAMP signaling pathway_Homo sapiens_hsa04024	1.17779951
41	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.17035390
42	RNA degradation_Homo sapiens_hsa03018	1.10993399
43	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.10467449
44	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.09577664
45	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.09253728
46	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.07586948
47	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.06530241
48	Pancreatic secretion_Homo sapiens_hsa04972	1.05674606
49	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.04134678
50	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.03620939
51	Long-term potentiation_Homo sapiens_hsa04720	1.02985824
52	Gastric acid secretion_Homo sapiens_hsa04971	1.02751282
53	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.02569450
54	Long-term depression_Homo sapiens_hsa04730	1.01906807
55	Tight junction_Homo sapiens_hsa04530	0.97148381
56	Linoleic acid metabolism_Homo sapiens_hsa00591	0.96990056
57	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.96658402
58	Lysine degradation_Homo sapiens_hsa00310	0.96655407
59	Cardiac muscle contraction_Homo sapiens_hsa04260	0.95194536
60	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.93634922
61	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.92644212
62	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.91976978
63	Basal transcription factors_Homo sapiens_hsa03022	0.90618642
64	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.88418098
65	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.85488397
66	Estrogen signaling pathway_Homo sapiens_hsa04915	0.82692995
67	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.82616475
68	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.81619579
69	Ether lipid metabolism_Homo sapiens_hsa00565	0.81137938
70	Glucagon signaling pathway_Homo sapiens_hsa04922	0.79724043
71	Protein digestion and absorption_Homo sapiens_hsa04974	0.79467061
72	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.79183039
73	Oocyte meiosis_Homo sapiens_hsa04114	0.74675117
74	Adherens junction_Homo sapiens_hsa04520	0.71998495
75	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.69532585
76	Type II diabetes mellitus_Homo sapiens_hsa04930	0.69432305
77	ECM-receptor interaction_Homo sapiens_hsa04512	0.68719709
78	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.66353234
79	Fanconi anemia pathway_Homo sapiens_hsa03460	0.65675561
80	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.63547495
81	Selenocompound metabolism_Homo sapiens_hsa00450	0.63199234
82	Nitrogen metabolism_Homo sapiens_hsa00910	0.62050068
83	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.61913711
84	ABC transporters_Homo sapiens_hsa02010	0.58996800
85	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.57452871
86	Tryptophan metabolism_Homo sapiens_hsa00380	0.51164761
87	Prostate cancer_Homo sapiens_hsa05215	0.49931210
88	Colorectal cancer_Homo sapiens_hsa05210	0.49390818
89	Bile secretion_Homo sapiens_hsa04976	0.49309891
90	MAPK signaling pathway_Homo sapiens_hsa04010	0.48486880
91	Ras signaling pathway_Homo sapiens_hsa04014	0.48023236
92	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.45922301
93	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.44451238
94	Melanoma_Homo sapiens_hsa05218	0.43348386
95	MicroRNAs in cancer_Homo sapiens_hsa05206	0.42558007
96	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.41813310
97	Rap1 signaling pathway_Homo sapiens_hsa04015	0.39046002
98	GnRH signaling pathway_Homo sapiens_hsa04912	0.38028163
99	Pathways in cancer_Homo sapiens_hsa05200	0.36007118
100	Homologous recombination_Homo sapiens_hsa03440	0.34743311

ZNF827

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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