ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.46847861
2	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.39959168
3	epithelial cilium movement (GO:0003351)	3.66820218
4	interkinetic nuclear migration (GO:0022027)	3.55222528
5	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.50865766
6	response to pheromone (GO:0019236)	3.48545699
7	dendritic spine morphogenesis (GO:0060997)	3.38096049
8	gamma-aminobutyric acid transport (GO:0015812)	3.28864593
9	regulation of cilium movement (GO:0003352)	3.23078765
10	protein localization to cilium (GO:0061512)	3.16723414
11	presynaptic membrane organization (GO:0097090)	3.15408101
12	protein localization to Golgi apparatus (GO:0034067)	3.14607987
13	cilium movement (GO:0003341)	3.12458131
14	establishment of protein localization to Golgi (GO:0072600)	3.11004293
15	tachykinin receptor signaling pathway (GO:0007217)	3.10066832
16	nonmotile primary cilium assembly (GO:0035058)	3.04158489
17	presynaptic membrane assembly (GO:0097105)	3.03947770
18	transmission of nerve impulse (GO:0019226)	2.99000825
19	nephron tubule morphogenesis (GO:0072078)	2.97328571
20	nephron epithelium morphogenesis (GO:0072088)	2.97328571
21	auditory receptor cell differentiation (GO:0042491)	2.96845708
22	behavioral response to ethanol (GO:0048149)	2.96441606
23	axoneme assembly (GO:0035082)	2.91778280
24	detection of light stimulus involved in sensory perception (GO:0050962)	2.90924587
25	detection of light stimulus involved in visual perception (GO:0050908)	2.90924587
26	cilium or flagellum-dependent cell motility (GO:0001539)	2.85273616
27	intraciliary transport (GO:0042073)	2.85112260
28	neural tube formation (GO:0001841)	2.82287535
29	indolalkylamine metabolic process (GO:0006586)	2.80757786
30	parturition (GO:0007567)	2.80238771
31	histone H3-K4 trimethylation (GO:0080182)	2.78538787
32	kidney morphogenesis (GO:0060993)	2.74006956
33	cilium morphogenesis (GO:0060271)	2.72268093
34	photoreceptor cell maintenance (GO:0045494)	2.68910767
35	central nervous system myelination (GO:0022010)	2.68889380
36	axon ensheathment in central nervous system (GO:0032291)	2.68889380
37	peristalsis (GO:0030432)	2.67364870
38	pyrimidine nucleobase catabolic process (GO:0006208)	2.66687102
39	indole-containing compound catabolic process (GO:0042436)	2.65448554
40	indolalkylamine catabolic process (GO:0046218)	2.65448554
41	tryptophan catabolic process (GO:0006569)	2.65448554
42	cilium organization (GO:0044782)	2.64557426
43	regulation of collateral sprouting (GO:0048670)	2.62741032
44	cilium assembly (GO:0042384)	2.62334115
45	cornea development in camera-type eye (GO:0061303)	2.60727664
46	brain morphogenesis (GO:0048854)	2.59442462
47	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.59293820
48	protein targeting to Golgi (GO:0000042)	2.59199003
49	renal tubule morphogenesis (GO:0061333)	2.58209492
50	dentate gyrus development (GO:0021542)	2.57986340
51	cellular ketone body metabolic process (GO:0046950)	2.55435048
52	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.55173686
53	appendage development (GO:0048736)	2.54825809
54	limb development (GO:0060173)	2.54825809
55	head development (GO:0060322)	2.53634972
56	estrogen biosynthetic process (GO:0006703)	2.52917168
57	phasic smooth muscle contraction (GO:0014821)	2.52174975
58	positive regulation of growth hormone secretion (GO:0060124)	2.50333826
59	snRNA transcription (GO:0009301)	2.49139240
60	neuronal action potential (GO:0019228)	2.48872999
61	protein polyglutamylation (GO:0018095)	2.46800917
62	regulation of female gonad development (GO:2000194)	2.46006523
63	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.45982210
64	centriole replication (GO:0007099)	2.45804269
65	retinal cone cell development (GO:0046549)	2.45003692
66	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.43159383
67	sulfation (GO:0051923)	2.42929044
68	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.40802194
69	substrate-independent telencephalic tangential migration (GO:0021826)	2.40802194
70	cAMP catabolic process (GO:0006198)	2.39741248
71	auditory behavior (GO:0031223)	2.39704916
72	reflex (GO:0060004)	2.39161770
73	negative regulation of systemic arterial blood pressure (GO:0003085)	2.36934856
74	L-fucose catabolic process (GO:0042355)	2.36449915
75	fucose catabolic process (GO:0019317)	2.36449915
76	L-fucose metabolic process (GO:0042354)	2.36449915
77	inner ear receptor stereocilium organization (GO:0060122)	2.34402701
78	photoreceptor cell development (GO:0042461)	2.34125596
79	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	2.33186639
80	monoubiquitinated protein deubiquitination (GO:0035520)	2.30875628
81	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.30579392
82	regulation of translation, ncRNA-mediated (GO:0045974)	2.30579392
83	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.30579392
84	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.29999557
85	forebrain morphogenesis (GO:0048853)	2.29889988
86	rhodopsin mediated signaling pathway (GO:0016056)	2.29160224
87	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.28983662
88	nucleobase catabolic process (GO:0046113)	2.27891067
89	nucleus localization (GO:0051647)	2.27664315
90	negative regulation of mast cell activation (GO:0033004)	2.27611093
91	prostate gland growth (GO:0060736)	2.26848481
92	membrane depolarization during action potential (GO:0086010)	2.26437249
93	synapse assembly (GO:0007416)	2.26007237
94	regulation of sarcomere organization (GO:0060297)	2.25823749
95	cyclic nucleotide catabolic process (GO:0009214)	2.25590403
96	neuronal action potential propagation (GO:0019227)	2.25071878
97	regulation of microtubule-based movement (GO:0060632)	2.24799003
98	axonal fasciculation (GO:0007413)	2.24083166
99	urinary tract smooth muscle contraction (GO:0014848)	2.22703567
100	cellular response to sterol (GO:0036315)	2.22504584

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.22731390
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.21022642
3	ZNF274_21170338_ChIP-Seq_K562_Hela	2.94015612
4	VDR_22108803_ChIP-Seq_LS180_Human	2.51158804
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.47880360
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.47521835
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.34860510
8	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.27525177
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.21074086
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.17280116
11	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.06001820
12	FUS_26573619_Chip-Seq_HEK293_Human	1.99122182
13	TAF15_26573619_Chip-Seq_HEK293_Human	1.97565375
14	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.95442970
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.89935135
16	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.89899820
17	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.88139525
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.84599976
19	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.82818237
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.81748239
21	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.80233865
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.78163042
23	P300_19829295_ChIP-Seq_ESCs_Human	1.77672439
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.75105502
25	EWS_26573619_Chip-Seq_HEK293_Human	1.74337263
26	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.67644586
27	STAT3_23295773_ChIP-Seq_U87_Human	1.63331827
28	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.60313789
29	REST_21632747_ChIP-Seq_MESCs_Mouse	1.56351853
30	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.56227961
31	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.55301562
32	TCF4_23295773_ChIP-Seq_U87_Human	1.52651378
33	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.51508389
34	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.51459012
35	BCAT_22108803_ChIP-Seq_LS180_Human	1.51013712
36	AR_25329375_ChIP-Seq_VCAP_Human	1.48109121
37	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.47208543
38	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.46862027
39	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.46862027
40	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.46365200
41	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.45842267
42	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.42435864
43	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.40562444
44	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.38215675
45	CBP_20019798_ChIP-Seq_JUKART_Human	1.36013425
46	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.36013425
47	DROSHA_22980978_ChIP-Seq_HELA_Human	1.35808945
48	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.34813864
49	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.33287934
50	RUNX2_22187159_ChIP-Seq_PCA_Human	1.31501468
51	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.30122232
52	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.29281895
53	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.27899575
54	RNF2_27304074_Chip-Seq_NSC_Mouse	1.27839900
55	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.27076291
56	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.26997715
57	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.25338326
58	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.24661160
59	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24506082
60	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.24241037
61	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.24215509
62	AR_21572438_ChIP-Seq_LNCaP_Human	1.23854797
63	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.23585708
64	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.21793974
65	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.21680262
66	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.20840645
67	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.20416736
68	IRF1_19129219_ChIP-ChIP_H3396_Human	1.20107972
69	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.19970393
70	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.19266932
71	* TCF4_22108803_ChIP-Seq_LS180_Human	1.18134218
72	P53_22387025_ChIP-Seq_ESCs_Mouse	1.15946467
73	* KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.15621106
74	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.13906314
75	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.13100543
76	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.12913493
77	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.10664843
78	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.10409641
79	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.10188814
80	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.10063774
81	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.08300355
82	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.08043667
83	TP53_22573176_ChIP-Seq_HFKS_Human	1.07714943
84	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.07711035
85	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.06751193
86	SOX2_19829295_ChIP-Seq_ESCs_Human	1.05089717
87	NANOG_19829295_ChIP-Seq_ESCs_Human	1.05089717
88	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.04904775
89	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.04827490
90	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.03787353
91	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.03547983
92	AHR_22903824_ChIP-Seq_MCF-7_Human	1.03456518
93	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.03177184
94	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.02996613
95	CDX2_22108803_ChIP-Seq_LS180_Human	1.02911511
96	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.01781706
97	* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.01337535
98	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.01106887
99	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.99439612
100	KDM2B_26808549_Chip-Seq_REH_Human	0.99296726

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	3.76907409
2	MP0008877_abnormal_DNA_methylation	2.63476944
3	MP0005646_abnormal_pituitary_gland	2.44749654
4	MP0003880_abnormal_central_pattern	2.28274391
5	MP0005551_abnormal_eye_electrophysiolog	2.16018207
6	MP0002837_dystrophic_cardiac_calcinosis	2.15513485
7	MP0002638_abnormal_pupillary_reflex	2.01674232
8	MP0001986_abnormal_taste_sensitivity	1.98167586
9	MP0003195_calcinosis	1.93101661
10	MP0003011_delayed_dark_adaptation	1.92862323
11	MP0001968_abnormal_touch/_nociception	1.90605953
12	MP0006276_abnormal_autonomic_nervous	1.88112869
13	MP0002876_abnormal_thyroid_physiology	1.87637999
14	MP0009745_abnormal_behavioral_response	1.82886476
15	MP0001486_abnormal_startle_reflex	1.79947366
16	MP0001984_abnormal_olfaction	1.79438891
17	MP0004145_abnormal_muscle_electrophysio	1.78385015
18	MP0006072_abnormal_retinal_apoptosis	1.73119786
19	MP0005423_abnormal_somatic_nervous	1.70283352
20	MP0009046_muscle_twitch	1.68752064
21	MP0005253_abnormal_eye_physiology	1.67940569
22	MP0003121_genomic_imprinting	1.67524918
23	MP0002928_abnormal_bile_duct	1.65815547
24	MP0001501_abnormal_sleep_pattern	1.64880383
25	MP0004142_abnormal_muscle_tone	1.64398557
26	MP0004885_abnormal_endolymph	1.64169574
27	MP0002557_abnormal_social/conspecific_i	1.63433624
28	MP0000569_abnormal_digit_pigmentation	1.60376564
29	MP0002272_abnormal_nervous_system	1.59589605
30	MP0002653_abnormal_ependyma_morphology	1.57943065
31	MP0002572_abnormal_emotion/affect_behav	1.57508859
32	MP0002163_abnormal_gland_morphology	1.55834029
33	MP0006292_abnormal_olfactory_placode	1.54928369
34	MP0000631_abnormal_neuroendocrine_gland	1.52311756
35	MP0005379_endocrine/exocrine_gland_phen	1.52288518
36	MP0002909_abnormal_adrenal_gland	1.50117072
37	MP0002822_catalepsy	1.47482475
38	MP0001970_abnormal_pain_threshold	1.47211865
39	MP0008872_abnormal_physiological_respon	1.47008696
40	MP0002102_abnormal_ear_morphology	1.45213626
41	MP0000427_abnormal_hair_cycle	1.45147472
42	MP0001485_abnormal_pinna_reflex	1.39346484
43	MP0000778_abnormal_nervous_system	1.38856282
44	MP0004043_abnormal_pH_regulation	1.37834309
45	MP0010386_abnormal_urinary_bladder	1.36723563
46	MP0005645_abnormal_hypothalamus_physiol	1.34878897
47	MP0002063_abnormal_learning/memory/cond	1.33374181
48	MP0003635_abnormal_synaptic_transmissio	1.32390933
49	MP0002064_seizures	1.31976573
50	MP0003123_paternal_imprinting	1.30674690
51	MP0003122_maternal_imprinting	1.27849739
52	MP0004924_abnormal_behavior	1.25147090
53	MP0005386_behavior/neurological_phenoty	1.25147090
54	MP0004133_heterotaxia	1.24305789
55	MP0008995_early_reproductive_senescence	1.23590819
56	MP0002734_abnormal_mechanical_nocicepti	1.22622042
57	MP0002733_abnormal_thermal_nociception	1.22251494
58	MP0003890_abnormal_embryonic-extraembry	1.20813130
59	MP0000639_abnormal_adrenal_gland	1.16795644
60	MP0002067_abnormal_sensory_capabilities	1.16114323
61	MP0002160_abnormal_reproductive_system	1.15747739
62	MP0005075_abnormal_melanosome_morpholog	1.10290239
63	MP0005174_abnormal_tail_pigmentation	1.08857231
64	MP0000230_abnormal_systemic_arterial	1.07909723
65	MP0000383_abnormal_hair_follicle	1.06968241
66	MP0002735_abnormal_chemical_nociception	1.05955015
67	MP0002938_white_spotting	1.05696889
68	MP0003646_muscle_fatigue	1.04778159
69	MP0003136_yellow_coat_color	1.04004722
70	MP0002736_abnormal_nociception_after	1.03979937
71	MP0001502_abnormal_circadian_rhythm	1.02616931
72	MP0001440_abnormal_grooming_behavior	1.01788492
73	MP0002752_abnormal_somatic_nervous	1.01423790
74	MP0002184_abnormal_innervation	1.00741244
75	MP0004742_abnormal_vestibular_system	0.99649993
76	MP0005389_reproductive_system_phenotype	0.96921597
77	MP0008775_abnormal_heart_ventricle	0.95731519
78	MP0000538_abnormal_urinary_bladder	0.95706082
79	MP0000372_irregular_coat_pigmentation	0.92698001
80	MP0001944_abnormal_pancreas_morphology	0.92376696
81	MP0004085_abnormal_heartbeat	0.92296413
82	MP0004147_increased_porphyrin_level	0.92022543
83	MP0001529_abnormal_vocalization	0.91970660
84	MP0002882_abnormal_neuron_morphology	0.91929022
85	MP0009780_abnormal_chondrocyte_physiolo	0.91667987
86	MP0004215_abnormal_myocardial_fiber	0.91415236
87	MP0002234_abnormal_pharynx_morphology	0.91232160
88	MP0005084_abnormal_gallbladder_morpholo	0.91029264
89	MP0002229_neurodegeneration	0.90619715
90	MP0010329_abnormal_lipoprotein_level	0.88767601
91	MP0001188_hyperpigmentation	0.88220062
92	MP0003633_abnormal_nervous_system	0.86329292
93	MP0005195_abnormal_posterior_eye	0.85658047
94	MP0005448_abnormal_energy_balance	0.85575918
95	MP0001905_abnormal_dopamine_level	0.84197950
96	MP0001963_abnormal_hearing_physiology	0.83663492
97	MP0000026_abnormal_inner_ear	0.83528545
98	MP0004019_abnormal_vitamin_homeostasis	0.83403578
99	MP0001756_abnormal_urination	0.81278585
100	MP0000955_abnormal_spinal_cord	0.80347441

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.30487849
2	Nephronophthisis (HP:0000090)	3.93838620
3	Pancreatic fibrosis (HP:0100732)	3.91326059
4	Abnormality of midbrain morphology (HP:0002418)	3.72528732
5	Molar tooth sign on MRI (HP:0002419)	3.72528732
6	Progressive cerebellar ataxia (HP:0002073)	3.69988194
7	True hermaphroditism (HP:0010459)	3.68499378
8	Abnormality of the renal medulla (HP:0100957)	3.68072407
9	Hyperventilation (HP:0002883)	3.59099566
10	Medial flaring of the eyebrow (HP:0010747)	3.56811004
11	Chronic hepatic failure (HP:0100626)	3.33347203
12	Genetic anticipation (HP:0003743)	3.29778551
13	Gait imbalance (HP:0002141)	3.20368384
14	Congenital primary aphakia (HP:0007707)	3.07383908
15	Cystic liver disease (HP:0006706)	3.06054645
16	Nephrogenic diabetes insipidus (HP:0009806)	2.99328083
17	Gaze-evoked nystagmus (HP:0000640)	2.93140240
18	Abnormality of the renal cortex (HP:0011035)	2.90455529
19	Genital tract atresia (HP:0001827)	2.83702362
20	Vaginal atresia (HP:0000148)	2.72378133
21	Decreased central vision (HP:0007663)	2.70697792
22	Congenital stationary night blindness (HP:0007642)	2.69139093
23	Protruding tongue (HP:0010808)	2.67478850
24	Attenuation of retinal blood vessels (HP:0007843)	2.56873511
25	Poor coordination (HP:0002370)	2.50317533
26	Absent speech (HP:0001344)	2.47288288
27	Tubular atrophy (HP:0000092)	2.46531914
28	Febrile seizures (HP:0002373)	2.39948223
29	Absent/shortened dynein arms (HP:0200106)	2.39941155
30	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.39941155
31	Hemiparesis (HP:0001269)	2.38741059
32	Type II lissencephaly (HP:0007260)	2.38223801
33	Abnormal rod and cone electroretinograms (HP:0008323)	2.33493864
34	Abnormal respiratory epithelium morphology (HP:0012253)	2.29290338
35	Abnormal respiratory motile cilium morphology (HP:0005938)	2.29290338
36	Furrowed tongue (HP:0000221)	2.24548148
37	Tubulointerstitial nephritis (HP:0001970)	2.23414825
38	Decreased circulating renin level (HP:0003351)	2.22023526
39	Polydipsia (HP:0001959)	2.20954892
40	Abnormal drinking behavior (HP:0030082)	2.20954892
41	Broad-based gait (HP:0002136)	2.19850017
42	Metaphyseal dysplasia (HP:0100255)	2.19600227
43	Abolished electroretinogram (ERG) (HP:0000550)	2.19234956
44	Drooling (HP:0002307)	2.15984678
45	Abnormal ciliary motility (HP:0012262)	2.14917934
46	Abnormal pancreas size (HP:0012094)	2.13813706
47	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.13668428
48	Congenital hepatic fibrosis (HP:0002612)	2.12621938
49	Male pseudohermaphroditism (HP:0000037)	2.12426274
50	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.11232207
51	Postaxial hand polydactyly (HP:0001162)	2.10728080
52	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.10101198
53	Tachypnea (HP:0002789)	2.05334295
54	Hypoplastic ischia (HP:0003175)	2.05159539
55	Abnormality of the pubic bones (HP:0003172)	2.04474777
56	Bony spicule pigmentary retinopathy (HP:0007737)	2.04332830
57	Postaxial foot polydactyly (HP:0001830)	2.02338087
58	Focal seizures (HP:0007359)	2.01713030
59	Large for gestational age (HP:0001520)	2.01039215
60	Abnormality of macular pigmentation (HP:0008002)	2.01035150
61	Intestinal atresia (HP:0011100)	1.99937024
62	Increased corneal curvature (HP:0100692)	1.99484920
63	Keratoconus (HP:0000563)	1.99484920
64	Widely spaced teeth (HP:0000687)	1.99408295
65	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.98694666
66	Asplenia (HP:0001746)	1.98307481
67	Excessive salivation (HP:0003781)	1.97457806
68	Short foot (HP:0001773)	1.97425172
69	Inability to walk (HP:0002540)	1.96308976
70	Cerebellar dysplasia (HP:0007033)	1.95447666
71	Renal cortical cysts (HP:0000803)	1.93025241
72	Sclerocornea (HP:0000647)	1.90995350
73	Fair hair (HP:0002286)	1.90554088
74	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.90180945
75	Agitation (HP:0000713)	1.85059795
76	Abnormal biliary tract physiology (HP:0012439)	1.84532850
77	Bile duct proliferation (HP:0001408)	1.84532850
78	Abnormal respiratory motile cilium physiology (HP:0012261)	1.84363957
79	Abnormality of the ischium (HP:0003174)	1.84348599
80	Specific learning disability (HP:0001328)	1.84089503
81	Stage 5 chronic kidney disease (HP:0003774)	1.83314100
82	Hypothermia (HP:0002045)	1.83045111
83	Tubulointerstitial abnormality (HP:0001969)	1.82053964
84	Hypoplastic iliac wings (HP:0002866)	1.81884451
85	Clumsiness (HP:0002312)	1.79641120
86	Papilledema (HP:0001085)	1.75284633
87	Thyroiditis (HP:0100646)	1.74498829
88	Thyroid-stimulating hormone excess (HP:0002925)	1.73940703
89	Aplasia/Hypoplasia of the lens (HP:0008063)	1.72461823
90	Anencephaly (HP:0002323)	1.70936217
91	Left ventricular hypertrophy (HP:0001712)	1.70489620
92	Enlarged kidneys (HP:0000105)	1.70015728
93	Retinitis pigmentosa (HP:0000510)	1.69632986
94	Narrow forehead (HP:0000341)	1.68421624
95	Chorioretinal atrophy (HP:0000533)	1.63933615
96	Lissencephaly (HP:0001339)	1.63121554
97	Polyuria (HP:0000103)	1.62891561
98	Rhinitis (HP:0012384)	1.62076346
99	Multicystic kidney dysplasia (HP:0000003)	1.60527935
100	Retinal dysplasia (HP:0007973)	1.57462727

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.61079021
2	BMPR1B	2.83161407
3	NTRK3	2.38112789
4	GRK1	2.31677263
5	ADRBK2	2.31104128
6	MAPK13	2.25684259
7	INSRR	2.18829670
8	FGFR2	2.16284175
9	CASK	2.14498122
10	WNK3	2.14036439
11	AKT3	2.11986929
12	MAP3K4	2.06320696
13	PINK1	1.96209068
14	DAPK2	1.85614169
15	ACVR1B	1.80970816
16	MAP4K2	1.72483822
17	NUAK1	1.51018453
18	TAOK3	1.49765656
19	TNK2	1.48398525
20	PAK3	1.45916382
21	WNK4	1.41480529
22	MAPK15	1.38536741
23	TXK	1.36008529
24	STK39	1.31913026
25	TRIM28	1.30205532
26	SGK2	1.30193600
27	MARK1	1.16026539
28	OXSR1	1.12374693
29	MUSK	1.11985618
30	NLK	1.08713561
31	PRKCE	1.08100164
32	TEC	1.06099199
33	PIK3CA	1.05683711
34	SGK494	1.03448927
35	SGK223	1.03448927
36	PRKD3	1.02115123
37	SIK2	1.00936019
38	PRKCH	0.96263609
39	ITK	0.88875739
40	MKNK2	0.87663244
41	MAP2K6	0.85684203
42	ERBB3	0.84830587
43	PRKCG	0.84798224
44	FLT3	0.84043286
45	DYRK1A	0.80245481
46	TRPM7	0.80098672
47	MAP2K7	0.79191902
48	TNIK	0.78908603
49	ADRBK1	0.78788385
50	MAPKAPK5	0.78643373
51	ERBB2	0.76575723
52	PTK2B	0.75770626
53	STK3	0.74708884
54	KIT	0.73908430
55	ZAK	0.73568311
56	MAPKAPK3	0.73170168
57	MAP3K7	0.72732764
58	NTRK2	0.72395007
59	TIE1	0.71855307
60	PRKCQ	0.70600341
61	MAP2K4	0.70279705
62	BCR	0.70227440
63	EIF2AK3	0.64978336
64	PNCK	0.64734920
65	EPHA4	0.63561838
66	STK38L	0.62768634
67	PRKAA1	0.60370753
68	TGFBR1	0.57980800
69	STK11	0.56927175
70	PLK2	0.55878602
71	PKN1	0.53808177
72	PIK3CG	0.52378166
73	CAMK1	0.51894241
74	MARK2	0.51790616
75	SGK3	0.51597862
76	FER	0.49808699
77	DYRK2	0.49518291
78	PRKCZ	0.49396623
79	PRKD2	0.49219315
80	MAP3K2	0.47159937
81	CAMK2A	0.46461919
82	PHKG2	0.45815896
83	PHKG1	0.45815896
84	PRKAA2	0.45354667
85	EPHA3	0.44288050
86	SGK1	0.44099354
87	PRKACA	0.43791548
88	MINK1	0.43209254
89	LCK	0.40575918
90	BTK	0.39787410
91	CDK3	0.39309764
92	WNK1	0.39075789
93	PRKG1	0.38534546
94	CDK5	0.37046563
95	CSNK1A1	0.35704772
96	UHMK1	0.35578593
97	OBSCN	0.32936493
98	CSNK1D	0.32648604
99	RPS6KA2	0.32599972
100	STK24	0.32488448

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.82063676
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.40609295
3	Butanoate metabolism_Homo sapiens_hsa00650	2.35142289
4	Nicotine addiction_Homo sapiens_hsa05033	2.23141716
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.21676070
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.18754693
7	Insulin secretion_Homo sapiens_hsa04911	1.92054670
8	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.90261259
9	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.84857322
10	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.83362303
11	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.81728318
12	Morphine addiction_Homo sapiens_hsa05032	1.77923896
13	Circadian entrainment_Homo sapiens_hsa04713	1.74779423
14	Glutamatergic synapse_Homo sapiens_hsa04724	1.73346774
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.73116693
16	ABC transporters_Homo sapiens_hsa02010	1.69617063
17	Taste transduction_Homo sapiens_hsa04742	1.65449629
18	Ether lipid metabolism_Homo sapiens_hsa00565	1.65181791
19	Nitrogen metabolism_Homo sapiens_hsa00910	1.60789110
20	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.57109033
21	GABAergic synapse_Homo sapiens_hsa04727	1.56401190
22	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.49787755
23	Olfactory transduction_Homo sapiens_hsa04740	1.48477163
24	Selenocompound metabolism_Homo sapiens_hsa00450	1.47147717
25	Serotonergic synapse_Homo sapiens_hsa04726	1.45751978
26	Tryptophan metabolism_Homo sapiens_hsa00380	1.43808589
27	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.42019917
28	Dopaminergic synapse_Homo sapiens_hsa04728	1.40094423
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.35963051
30	Long-term depression_Homo sapiens_hsa04730	1.24804810
31	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.23954216
32	Renin secretion_Homo sapiens_hsa04924	1.21557234
33	Cholinergic synapse_Homo sapiens_hsa04725	1.21305128
34	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.19390241
35	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.19297805
36	Regulation of autophagy_Homo sapiens_hsa04140	1.19054591
37	Glycerolipid metabolism_Homo sapiens_hsa00561	1.18957041
38	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.18160677
39	Calcium signaling pathway_Homo sapiens_hsa04020	1.12108679
40	Amphetamine addiction_Homo sapiens_hsa05031	1.10266845
41	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.08959753
42	Cocaine addiction_Homo sapiens_hsa05030	1.05956882
43	Propanoate metabolism_Homo sapiens_hsa00640	1.01763580
44	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.01369677
45	Salivary secretion_Homo sapiens_hsa04970	1.01199581
46	Peroxisome_Homo sapiens_hsa04146	0.97922405
47	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.95561216
48	Caffeine metabolism_Homo sapiens_hsa00232	0.95491285
49	cAMP signaling pathway_Homo sapiens_hsa04024	0.94203694
50	Chemical carcinogenesis_Homo sapiens_hsa05204	0.93254420
51	Retinol metabolism_Homo sapiens_hsa00830	0.92746618
52	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.92733610
53	Fanconi anemia pathway_Homo sapiens_hsa03460	0.89606849
54	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.88434981
55	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.84919105
56	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.80424301
57	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.79012730
58	Homologous recombination_Homo sapiens_hsa03440	0.78294879
59	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.75879023
60	Gastric acid secretion_Homo sapiens_hsa04971	0.75800104
61	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.74617239
62	Circadian rhythm_Homo sapiens_hsa04710	0.73941258
63	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.73299115
64	Steroid biosynthesis_Homo sapiens_hsa00100	0.72820716
65	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.72493815
66	Basal transcription factors_Homo sapiens_hsa03022	0.71870798
67	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.71245965
68	Collecting duct acid secretion_Homo sapiens_hsa04966	0.69496106
69	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.69390655
70	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.65705738
71	Protein export_Homo sapiens_hsa03060	0.65524532
72	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.62849179
73	Sphingolipid metabolism_Homo sapiens_hsa00600	0.62207211
74	Axon guidance_Homo sapiens_hsa04360	0.61620119
75	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.59751424
76	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.59665929
77	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.58420841
78	Type II diabetes mellitus_Homo sapiens_hsa04930	0.56815964
79	Choline metabolism in cancer_Homo sapiens_hsa05231	0.55813020
80	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.54422154
81	Ras signaling pathway_Homo sapiens_hsa04014	0.52351008
82	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.52071527
83	Lysine degradation_Homo sapiens_hsa00310	0.51561648
84	Histidine metabolism_Homo sapiens_hsa00340	0.51367573
85	Type I diabetes mellitus_Homo sapiens_hsa04940	0.50463361
86	Fat digestion and absorption_Homo sapiens_hsa04975	0.50325276
87	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.48671339
88	Pancreatic secretion_Homo sapiens_hsa04972	0.46850380
89	RNA degradation_Homo sapiens_hsa03018	0.46445596
90	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.45674218
91	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.44787487
92	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.42257607
93	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.41345705
94	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.40463375
95	Oxidative phosphorylation_Homo sapiens_hsa00190	0.38298004
96	beta-Alanine metabolism_Homo sapiens_hsa00410	0.37384508
97	MAPK signaling pathway_Homo sapiens_hsa04010	0.36529856
98	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.35123287
99	Bile secretion_Homo sapiens_hsa04976	0.34371515
100	Cardiac muscle contraction_Homo sapiens_hsa04260	0.32991064

ZNF83

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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