ZNF831

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.93731469
2negative regulation of cell killing (GO:0031342)6.76431014
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.76431014
4regulation of gamma-delta T cell differentiation (GO:0045586)6.17407257
5negative T cell selection (GO:0043383)6.16796955
6negative thymic T cell selection (GO:0045060)5.97408054
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.94517235
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.81965210
9regulation of gamma-delta T cell activation (GO:0046643)5.69703169
10regulation of B cell receptor signaling pathway (GO:0050855)5.51868751
11positive T cell selection (GO:0043368)5.42780696
12positive thymic T cell selection (GO:0045059)5.35208075
13response to interleukin-15 (GO:0070672)5.20162009
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.17656908
15thymic T cell selection (GO:0045061)5.07140942
16cellular response to interleukin-15 (GO:0071350)5.01862227
17activated T cell proliferation (GO:0050798)4.94454237
18T cell selection (GO:0045058)4.92033716
19tolerance induction (GO:0002507)4.81894364
20antigen processing and presentation of endogenous antigen (GO:0019883)4.73476475
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.66746430
22negative regulation of T cell mediated immunity (GO:0002710)4.52027849
23negative regulation of lymphocyte mediated immunity (GO:0002707)4.46316967
24regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.40706849
25interferon-gamma production (GO:0032609)4.39765663
26leukocyte aggregation (GO:0070486)4.38914137
27positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.32616004
28positive regulation of granulocyte differentiation (GO:0030854)4.14226175
29positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.11274670
30T cell migration (GO:0072678)4.10993128
31regulation of regulatory T cell differentiation (GO:0045589)4.07963558
32regulation of alpha-beta T cell proliferation (GO:0046640)4.00740997
33B cell receptor signaling pathway (GO:0050853)3.87239833
34regulation of B cell differentiation (GO:0045577)3.83267900
35regulation of isotype switching to IgG isotypes (GO:0048302)3.77827802
36negative regulation of leukocyte mediated immunity (GO:0002704)3.77802455
37positive regulation of alpha-beta T cell proliferation (GO:0046641)3.70262249
38regulation of natural killer cell mediated immunity (GO:0002715)3.69464108
39regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.69464108
40regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.69313025
41mucosal-associated lymphoid tissue development (GO:0048537)3.65131634
42Peyers patch development (GO:0048541)3.65131634
43regulation of T cell tolerance induction (GO:0002664)3.62467831
44negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.60546744
45T cell receptor signaling pathway (GO:0050852)3.58887257
46negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.53910286
47antigen receptor-mediated signaling pathway (GO:0050851)3.52943142
48lymph node development (GO:0048535)3.48885167
49positive regulation of B cell differentiation (GO:0045579)3.46618125
50G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.45930266
51regulation of T cell mediated cytotoxicity (GO:0001914)3.42971170
52negative regulation of adaptive immune response (GO:0002820)3.35346342
53regulation of interleukin-2 biosynthetic process (GO:0045076)3.34878373
54T cell homeostasis (GO:0043029)3.28067792
55negative regulation of B cell mediated immunity (GO:0002713)3.27365540
56negative regulation of immunoglobulin mediated immune response (GO:0002890)3.27365540
57positive regulation of interleukin-2 production (GO:0032743)3.26395948
58mast cell activation (GO:0045576)3.25697573
59positive regulation of natural killer cell mediated immunity (GO:0002717)3.25394366
60regulation of leukocyte mediated cytotoxicity (GO:0001910)3.25145593
61alpha-beta T cell differentiation (GO:0046632)3.23146757
62positive regulation of T cell mediated cytotoxicity (GO:0001916)3.22500928
63detection of bacterium (GO:0016045)3.20975124
64detection of other organism (GO:0098543)3.19859252
65positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.17153656
66regulation of granulocyte differentiation (GO:0030852)3.15236053
67regulation of tolerance induction (GO:0002643)3.12868978
68positive regulation of tolerance induction (GO:0002645)3.12093691
69histone H3-K36 demethylation (GO:0070544)3.11372814
70phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.05266671
71positive regulation of isotype switching (GO:0045830)3.02708629
72antigen processing and presentation via MHC class Ib (GO:0002475)3.01919237
73cellular extravasation (GO:0045123)2.99019277
74alpha-beta T cell activation (GO:0046631)2.97888906
75regulation of cell killing (GO:0031341)2.97839249
76natural killer cell differentiation (GO:0001779)2.97203873
77positive regulation of humoral immune response (GO:0002922)2.96683550
78negative regulation of innate immune response (GO:0045824)2.95873887
79negative regulation of glycoprotein biosynthetic process (GO:0010561)2.94304211
80positive regulation of cell killing (GO:0031343)2.92397820
81modulation by symbiont of host immune response (GO:0052553)2.91904277
82positive regulation by symbiont of host defense response (GO:0052509)2.91904277
83modulation by symbiont of host defense response (GO:0052031)2.91904277
84modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.91904277
85modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.91904277
86positive regulation by organism of defense response of other organism involved in symbiotic interact2.91904277
87negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.91328410
88mast cell degranulation (GO:0043303)2.90903925
89mast cell activation involved in immune response (GO:0002279)2.90903925
90regulation of T cell receptor signaling pathway (GO:0050856)2.90837623
91negative regulation of cAMP-mediated signaling (GO:0043951)2.89172862
92regulation of alpha-beta T cell activation (GO:0046634)2.87868638
93positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.87132198
94CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.85532499
95response to laminar fluid shear stress (GO:0034616)2.84870696
96T cell proliferation (GO:0042098)2.81990391
97T cell differentiation (GO:0030217)2.78940325
98T cell costimulation (GO:0031295)2.78103885
99negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.78001137
100negative regulation of T-helper cell differentiation (GO:0045623)2.78001137

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.43113331
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.03943564
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.30295650
4VDR_21846776_ChIP-Seq_THP-1_Human3.40800825
5RUNX_20019798_ChIP-Seq_JUKART_Human3.34871387
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.27784710
7MAF_26560356_Chip-Seq_TH1_Human3.23450003
8MYC_22102868_ChIP-Seq_BL_Human3.22535677
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.04044153
10UTX_26944678_Chip-Seq_JUKART_Human2.94551126
11MYB_26560356_Chip-Seq_TH2_Human2.93088081
12MAF_26560356_Chip-Seq_TH2_Human2.87278746
13MYB_26560356_Chip-Seq_TH1_Human2.62622152
14FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.57793739
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.55874708
16E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.54156415
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.52555110
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.48210897
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.45416571
20VDR_24763502_ChIP-Seq_THP-1_Human2.42967795
21SCL_19346495_ChIP-Seq_HPC-7_Human2.39657307
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.35920613
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.31455954
24KDM2B_26808549_Chip-Seq_SUP-B15_Human2.20687291
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.20519219
26TCF7_22412390_ChIP-Seq_EML_Mouse2.20116323
27NOTCH1_21737748_ChIP-Seq_TLL_Human2.19015769
28KDM2B_26808549_Chip-Seq_DND41_Human2.17045380
29KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.12382036
30KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.03921642
31GATA3_27048872_Chip-Seq_THYMUS_Human1.95859955
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.94955458
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93573639
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.92024762
35SPI1_23547873_ChIP-Seq_NB4_Human1.88938127
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.86239606
37GATA1_22025678_ChIP-Seq_K562_Human1.85698501
38CIITA_25753668_ChIP-Seq_RAJI_Human1.85085175
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.84312822
40MYB_21317192_ChIP-Seq_ERMYB_Mouse1.79874518
41STAT6_21828071_ChIP-Seq_BEAS2B_Human1.70513285
42IRF8_27001747_Chip-Seq_BMDM_Mouse1.68610698
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58795352
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.57777007
45KDM2B_26808549_Chip-Seq_JURKAT_Human1.57412384
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.55932954
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.49216404
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.47685587
49GATA3_26560356_Chip-Seq_TH2_Human1.44242969
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41212636
51SPI1_23127762_ChIP-Seq_K562_Human1.40077673
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34098799
53LXR_22292898_ChIP-Seq_THP-1_Human1.31644650
54BCOR_27268052_Chip-Seq_Bcells_Human1.31422567
55BCL6_27268052_Chip-Seq_Bcells_Human1.31287122
56PU.1_20513432_ChIP-Seq_Bcells_Mouse1.29070734
57TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28755418
58P68_20966046_ChIP-Seq_HELA_Human1.27372322
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23734466
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.23065407
61CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22530050
62GATA1_19941827_ChIP-Seq_MEL_Mouse1.19416237
63CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16627032
64CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16351795
65PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15664964
66STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15658499
67RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15439064
68CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14892489
69TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14423443
70PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12039459
71NCOR1_26117541_ChIP-Seq_K562_Human1.10080368
72GATA1_19941826_ChIP-Seq_K562_Human1.09437792
73GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07936956
74EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07624474
75CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07622106
76* SMC4_20622854_ChIP-Seq_HELA_Human1.07555879
77RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.05881287
78PU_27001747_Chip-Seq_BMDM_Mouse1.04990483
79GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04061796
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03447544
81SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02168676
82CTCF_21964334_ChIP-Seq_BJAB-B_Human1.01723092
83CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.01676332
84GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00232247
85RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99284024
86PKCTHETA_26484144_Chip-Seq_BREAST_Human0.99073247
87RACK7_27058665_Chip-Seq_MCF-7_Human0.98008171
88E2F1_20622854_ChIP-Seq_HELA_Human0.97055340
89CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96701524
90GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96546178
91CTCF_21964334_Chip-Seq_Bcells_Human0.94827689
92SMAD_19615063_ChIP-ChIP_OVARY_Human0.94757090
93SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93193935
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93188887
95ELF1_17652178_ChIP-ChIP_JURKAT_Human0.90144421
96PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89765893
97BP1_19119308_ChIP-ChIP_Hs578T_Human0.89242533
98SA1_27219007_Chip-Seq_ERYTHROID_Human0.89067961
99VDR_23849224_ChIP-Seq_CD4+_Human0.87118126
100RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84877208

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.95713138
2MP0005083_abnormal_biliary_tract3.79499981
3MP0005671_abnormal_response_to3.58132716
4MP0001835_abnormal_antigen_presentation3.28423359
5MP0003436_decreased_susceptibility_to3.16087208
6MP0001800_abnormal_humoral_immune3.15111717
7MP0003724_increased_susceptibility_to3.00401770
8MP0004381_abnormal_hair_follicle2.87770378
9MP0009333_abnormal_splenocyte_physiolog2.74389699
10MP0005000_abnormal_immune_tolerance2.73962175
11MP0002723_abnormal_immune_serum2.65366807
12MP0002420_abnormal_adaptive_immunity2.55397856
13MP0001819_abnormal_immune_cell2.51147306
14MP0001986_abnormal_taste_sensitivity2.43628858
15MP0005387_immune_system_phenotype2.43008603
16MP0001790_abnormal_immune_system2.43008603
17MP0002398_abnormal_bone_marrow2.40997276
18MP0000685_abnormal_immune_system2.40341901
19MP0002452_abnormal_antigen_presenting2.35448563
20MP0000703_abnormal_thymus_morphology2.34146049
21MP0005174_abnormal_tail_pigmentation2.27252600
22MP0005025_abnormal_response_to2.25238055
23MP0001873_stomach_inflammation2.17353118
24MP0000716_abnormal_immune_system2.13810735
25MP0002405_respiratory_system_inflammati2.13450650
26MP0002419_abnormal_innate_immunity2.08685102
27MP0003303_peritoneal_inflammation2.01441796
28MP0000689_abnormal_spleen_morphology1.98903462
29MP0002009_preneoplasia1.93405421
30MP0002722_abnormal_immune_system1.92487225
31MP0010155_abnormal_intestine_physiology1.84094877
32MP0006082_CNS_inflammation1.78301839
33MP0009785_altered_susceptibility_to1.77407652
34MP0002396_abnormal_hematopoietic_system1.77147991
35MP0003866_abnormal_defecation1.75430359
36MP0002429_abnormal_blood_cell1.74327302
37MP0002148_abnormal_hypersensitivity_rea1.72392160
38MP0004947_skin_inflammation1.59586547
39MP0002166_altered_tumor_susceptibility1.57482611
40MP0004130_abnormal_muscle_cell1.57371001
41MP0000015_abnormal_ear_pigmentation1.49866689
42MP0003300_gastrointestinal_ulcer1.48589434
43MP0001348_abnormal_lacrimal_gland1.47210580
44MP0001845_abnormal_inflammatory_respons1.44177590
45MP0000569_abnormal_digit_pigmentation1.37776910
46MP0008057_abnormal_DNA_replication1.36942326
47MP0005310_abnormal_salivary_gland1.36203291
48MP0002933_joint_inflammation1.33569229
49MP0005171_absent_coat_pigmentation1.33265153
50MP0004808_abnormal_hematopoietic_stem1.29793075
51MP0005464_abnormal_platelet_physiology1.18435037
52MP0001851_eye_inflammation1.14734824
53MP0001533_abnormal_skeleton_physiology1.13735189
54MP0008469_abnormal_protein_level1.13169819
55MP0009278_abnormal_bone_marrow1.13109036
56MP0000465_gastrointestinal_hemorrhage1.13021854
57MP0005423_abnormal_somatic_nervous1.11170735
58MP0002019_abnormal_tumor_incidence1.03198755
59MP0005076_abnormal_cell_differentiation1.01066234
60MP0000858_altered_metastatic_potential0.97099238
61MP0003172_abnormal_lysosome_physiology0.96578950
62MP0002006_tumorigenesis0.95535791
63MP0005075_abnormal_melanosome_morpholog0.95258050
64MP0008260_abnormal_autophagy0.95009211
65MP0003091_abnormal_cell_migration0.90841779
66MP0003448_altered_tumor_morphology0.88912163
67MP0000490_abnormal_crypts_of0.86036070
68MP0005451_abnormal_body_composition0.81942572
69MP0003828_pulmonary_edema0.78778108
70MP0002277_abnormal_respiratory_mucosa0.78515310
71MP0005584_abnormal_enzyme/coenzyme_acti0.76924208
72MP0002998_abnormal_bone_remodeling0.75953103
73MP0001853_heart_inflammation0.75449942
74MP0008961_abnormal_basal_metabolism0.74802883
75MP0003453_abnormal_keratinocyte_physiol0.73744964
76MP0003136_yellow_coat_color0.72461988
77MP0002132_abnormal_respiratory_system0.69656803
78MP0003656_abnormal_erythrocyte_physiolo0.68805545
79MP0003183_abnormal_peptide_metabolism0.68476318
80MP0004883_abnormal_blood_vessel0.67718449
81MP0003045_fibrosis0.65869991
82MP0002928_abnormal_bile_duct0.61868882
83MP0001663_abnormal_digestive_system0.60257183
84MP0005085_abnormal_gallbladder_physiolo0.59766062
85MP0001919_abnormal_reproductive_system0.59206793
86MP0002136_abnormal_kidney_physiology0.59094579
87MP0005409_darkened_coat_color0.59035302
88MP0001765_abnormal_ion_homeostasis0.57745108
89MP0009764_decreased_sensitivity_to0.57635024
90MP0009763_increased_sensitivity_to0.57122809
91MP0000003_abnormal_adipose_tissue0.56695310
92MP0008874_decreased_physiological_sensi0.56687654
93MP0000249_abnormal_blood_vessel0.55631606
94MP0002693_abnormal_pancreas_physiology0.54271937
95MP0002138_abnormal_hepatobiliary_system0.51991224
96MP0000367_abnormal_coat/_hair0.51930315
97MP0001661_extended_life_span0.49404745
98MP0002638_abnormal_pupillary_reflex0.49005263
99MP0003077_abnormal_cell_cycle0.48737304
100MP0004484_altered_response_of0.48073373

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.73285241
2Abnormality of T cell number (HP:0011839)5.27592097
3Eczematoid dermatitis (HP:0000976)4.73745958
4Pustule (HP:0200039)4.51756683
5Elevated erythrocyte sedimentation rate (HP:0003565)4.46692831
6Myositis (HP:0100614)4.21478815
7Recurrent bacterial skin infections (HP:0005406)4.06031358
8Recurrent fungal infections (HP:0002841)4.05952054
9Abnormality of T cells (HP:0002843)4.04161544
10Abnormal delayed hypersensitivity skin test (HP:0002963)3.98370129
11Stomatitis (HP:0010280)3.86345607
12Recurrent abscess formation (HP:0002722)3.80719157
13Gastrointestinal infarctions (HP:0005244)3.63487596
14Panhypogammaglobulinemia (HP:0003139)3.62472830
15Severe combined immunodeficiency (HP:0004430)3.53122516
16Recurrent cutaneous fungal infections (HP:0011370)3.41978387
17Chronic mucocutaneous candidiasis (HP:0002728)3.41978387
18Retrobulbar optic neuritis (HP:0100654)3.37729120
19Optic neuritis (HP:0100653)3.37729120
20Orchitis (HP:0100796)3.30955959
21Recurrent viral infections (HP:0004429)3.17512208
22Meningitis (HP:0001287)3.15665783
23IgG deficiency (HP:0004315)3.12674947
24Encephalitis (HP:0002383)3.09323049
25Abnormality of eosinophils (HP:0001879)3.08755108
26Inflammation of the large intestine (HP:0002037)3.04602641
27Autoimmune hemolytic anemia (HP:0001890)3.01930132
28Colitis (HP:0002583)3.01770855
29Recurrent skin infections (HP:0001581)3.01259236
30Basal cell carcinoma (HP:0002671)2.97973282
31Spontaneous hematomas (HP:0007420)2.95284748
32IgM deficiency (HP:0002850)2.95204751
33Abnormality of macrophages (HP:0004311)2.93551781
34Gastrointestinal inflammation (HP:0004386)2.88536662
35Recurrent bronchitis (HP:0002837)2.84620264
36Vasculitis (HP:0002633)2.84359826
37Abnormality of T cell physiology (HP:0011840)2.81386361
38Leukocytosis (HP:0001974)2.76432358
39Abnormality of the fingertips (HP:0001211)2.76264283
40Granulocytopenia (HP:0001913)2.76167509
41Hypochromic anemia (HP:0001931)2.73211864
42Mediastinal lymphadenopathy (HP:0100721)2.71718743
43Poikiloderma (HP:0001029)2.69910104
44Combined immunodeficiency (HP:0005387)2.69621421
45Lymphopenia (HP:0001888)2.67193447
46Hypoplasia of the thymus (HP:0000778)2.65382749
47Eosinophilia (HP:0001880)2.61711325
48Anorexia (HP:0002039)2.56092372
49Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.55176442
50Chest pain (HP:0100749)2.54877129
51Dyschromatopsia (HP:0007641)2.50250228
52Abnormality of cells of the lymphoid lineage (HP:0012140)2.49292292
53Abnormality of the nasal septum (HP:0000419)2.48854990
54Chronic obstructive pulmonary disease (HP:0006510)2.44102543
55Obstructive lung disease (HP:0006536)2.44102543
56Pulmonary infiltrates (HP:0002113)2.39743197
57Epistaxis (HP:0000421)2.39484174
58Premature graying of hair (HP:0002216)2.37228112
59Keratoconjunctivitis sicca (HP:0001097)2.36366442
60Prolonged bleeding time (HP:0003010)2.36138794
61Lymphoma (HP:0002665)2.36107584
62Testicular atrophy (HP:0000029)2.33851600
63Increased IgE level (HP:0003212)2.33470224
64Keratoconjunctivitis (HP:0001096)2.32361281
65Slow saccadic eye movements (HP:0000514)2.31667023
66Verrucae (HP:0200043)2.28603351
67Papilloma (HP:0012740)2.28603351
68Papilledema (HP:0001085)2.26551345
69Acute hepatic failure (HP:0006554)2.25405764
70Agammaglobulinemia (HP:0004432)2.21569669
71Attenuation of retinal blood vessels (HP:0007843)2.19523318
72Increased IgM level (HP:0003496)2.17800211
73Chronic diarrhea (HP:0002028)2.16819020
74Hemoptysis (HP:0002105)2.15922207
75Dislocated radial head (HP:0003083)2.15439799
76Facial diplegia (HP:0001349)2.15023225
77Recurrent gram-negative bacterial infections (HP:0005420)2.12981324
78Annular pancreas (HP:0001734)2.12373138
79Thyroiditis (HP:0100646)2.10131244
80Rib fusion (HP:0000902)2.09921711
81Lip pit (HP:0100267)2.08146138
82IgA deficiency (HP:0002720)2.06700548
83Hypoalbuminemia (HP:0003073)2.05378102
84Abnormal albumin level (HP:0012116)2.05378102
85Arterial thrombosis (HP:0004420)2.01470801
86Autoimmune thrombocytopenia (HP:0001973)1.98950806
87Thin bony cortex (HP:0002753)1.98685800
88Abnormality of B cell number (HP:0010975)1.96604199
89Abnormality of the radial head (HP:0003995)1.94786689
90Gingivitis (HP:0000230)1.93665468
91Prominent nose (HP:0000448)1.89187523
92Viral hepatitis (HP:0006562)1.84931647
93Cellulitis (HP:0100658)1.82878648
94Short chin (HP:0000331)1.81799358
95Pulmonary embolism (HP:0002204)1.79773525
96Aplasia/Hypoplasia of the thymus (HP:0010515)1.79245852
97Intestinal fistula (HP:0100819)1.79097482
98Joint hemorrhage (HP:0005261)1.79059327
99Subacute progressive viral hepatitis (HP:0006572)1.77981314
100Squamous cell carcinoma (HP:0002860)1.76686330

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.53303249
2TXK3.84583725
3PDK23.24092992
4RIPK42.96758754
5GRK62.83049843
6BLK2.68139303
7PRPF4B2.56166115
8ZAP702.26835738
9BTK2.18831720
10CSK2.16283826
11FES2.07516056
12TYK21.95956278
13ITK1.95228707
14IKBKE1.77291664
15TAOK31.71922195
16JAK31.71204967
17MAPK151.67353144
18MAP2K31.63787151
19TESK21.63685237
20SYK1.62400925
21TLK11.60992093
22MAP3K101.60806880
23WNK41.56482655
24NEK61.52654133
25MAP3K131.48854742
26JAK11.45931190
27CAMKK21.44519887
28ERN11.42436240
29TNK21.41813260
30LCK1.40265025
31HCK1.38737714
32SIK21.34859782
33PIM11.34411679
34IRAK41.33090831
35CDK121.32799973
36NLK1.29461886
37MAPK121.26461589
38MAP3K141.25228403
39MARK31.20511094
40TEC1.14073845
41SIK31.10726150
42BMPR21.10303485
43LYN1.08780751
44RAF11.08183450
45MAPK111.06431873
46CDK41.05856719
47MAPK71.01980737
48PDK11.01908529
49CAMKK11.01220259
50IKBKB0.99463521
51PRKCQ0.94188329
52EPHB10.94113541
53PASK0.93043859
54MELK0.92001177
55TBK10.90523180
56MAP3K10.90115827
57MARK20.87791936
58FGFR30.87117989
59PDPK10.85727903
60JAK20.85005101
61STK100.81683559
62STK110.80667897
63MAP3K30.76767281
64FGFR40.75720504
65ACVR1B0.73563890
66HIPK20.72366679
67CDK60.71778049
68ICK0.69882008
69TRIB30.69574067
70MAP3K70.68974624
71TYRO30.64677244
72BRD40.63814491
73STK390.62944265
74MAP3K110.61037953
75MUSK0.59532031
76TGFBR20.58062368
77KSR20.56800434
78OXSR10.55454794
79YES10.55425171
80PIK3CG0.55123124
81MAP2K60.51763644
82SIK10.51295829
83WNK10.50683873
84PIM20.49980561
85TAOK10.47399827
86MAP2K20.44566586
87SMG10.40999430
88PDGFRB0.40925137
89STK380.40834131
90ZAK0.39058623
91CSF1R0.38049452
92FGR0.37430168
93TAOK20.37291474
94RPS6KA60.33824467
95DYRK1B0.33296045
96FYN0.33219341
97PTK60.32732747
98CAMK40.32305716
99RPS6KL10.32033784
100RPS6KC10.32033784

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.14922153
2T cell receptor signaling pathway_Homo sapiens_hsa046602.99970052
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.57017783
4Graft-versus-host disease_Homo sapiens_hsa053322.49866159
5B cell receptor signaling pathway_Homo sapiens_hsa046622.31798553
6Autoimmune thyroid disease_Homo sapiens_hsa053202.30846384
7Allograft rejection_Homo sapiens_hsa053302.30264080
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.19841705
9Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.15440911
10Osteoclast differentiation_Homo sapiens_hsa043802.12347083
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.08441425
12Measles_Homo sapiens_hsa051621.98019728
13Hematopoietic cell lineage_Homo sapiens_hsa046401.91512243
14Leishmaniasis_Homo sapiens_hsa051401.76677268
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.73642975
16Acute myeloid leukemia_Homo sapiens_hsa052211.73441003
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.70524037
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.67588412
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.62454011
20Antigen processing and presentation_Homo sapiens_hsa046121.52138880
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.51662059
22Type I diabetes mellitus_Homo sapiens_hsa049401.49443283
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.46604928
24Non-small cell lung cancer_Homo sapiens_hsa052231.46208975
25Viral myocarditis_Homo sapiens_hsa054161.44414820
26Chemokine signaling pathway_Homo sapiens_hsa040621.41361711
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.34012012
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.32804826
29Phosphatidylinositol signaling system_Homo sapiens_hsa040701.30128878
30Hepatitis B_Homo sapiens_hsa051611.27906747
31Herpes simplex infection_Homo sapiens_hsa051681.27314904
32Staphylococcus aureus infection_Homo sapiens_hsa051501.25303589
33Toxoplasmosis_Homo sapiens_hsa051451.25239314
34FoxO signaling pathway_Homo sapiens_hsa040681.22264717
35TNF signaling pathway_Homo sapiens_hsa046681.21859761
36Tuberculosis_Homo sapiens_hsa051521.21591689
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16743247
38Inositol phosphate metabolism_Homo sapiens_hsa005621.12025273
39Influenza A_Homo sapiens_hsa051641.10584087
40Apoptosis_Homo sapiens_hsa042101.07293576
41VEGF signaling pathway_Homo sapiens_hsa043701.07231291
42Platelet activation_Homo sapiens_hsa046111.04677867
43Chronic myeloid leukemia_Homo sapiens_hsa052201.03332475
44Circadian rhythm_Homo sapiens_hsa047101.02064466
45mTOR signaling pathway_Homo sapiens_hsa041500.99433788
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.97697235
47Pancreatic cancer_Homo sapiens_hsa052120.96802110
48HTLV-I infection_Homo sapiens_hsa051660.96748756
49Colorectal cancer_Homo sapiens_hsa052100.93207838
50Malaria_Homo sapiens_hsa051440.92643972
51Endometrial cancer_Homo sapiens_hsa052130.92361731
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90924677
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.89532571
54Dorso-ventral axis formation_Homo sapiens_hsa043200.87552583
55Viral carcinogenesis_Homo sapiens_hsa052030.85288738
56Hepatitis C_Homo sapiens_hsa051600.80595541
57Epstein-Barr virus infection_Homo sapiens_hsa051690.80062297
58Sulfur relay system_Homo sapiens_hsa041220.79816662
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.72050783
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71310760
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70572028
62Prolactin signaling pathway_Homo sapiens_hsa049170.70283075
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.68597771
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66896867
65Regulation of autophagy_Homo sapiens_hsa041400.65362078
66Asthma_Homo sapiens_hsa053100.65355913
67Renal cell carcinoma_Homo sapiens_hsa052110.64733039
68Other glycan degradation_Homo sapiens_hsa005110.64107565
69Insulin resistance_Homo sapiens_hsa049310.63978771
70MAPK signaling pathway_Homo sapiens_hsa040100.63890067
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62867575
72Thyroid cancer_Homo sapiens_hsa052160.62292558
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61015306
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59735509
75Choline metabolism in cancer_Homo sapiens_hsa052310.56271735
76Notch signaling pathway_Homo sapiens_hsa043300.55988691
77Endocytosis_Homo sapiens_hsa041440.54684197
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.54165517
79Legionellosis_Homo sapiens_hsa051340.52469881
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52102647
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.51940427
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.51830099
83Small cell lung cancer_Homo sapiens_hsa052220.46370962
84Pertussis_Homo sapiens_hsa051330.45546014
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45341916
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44696351
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44290558
88Prostate cancer_Homo sapiens_hsa052150.44100026
89African trypanosomiasis_Homo sapiens_hsa051430.42828645
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42383981
91GnRH signaling pathway_Homo sapiens_hsa049120.41877921
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.41544582
93ErbB signaling pathway_Homo sapiens_hsa040120.40400159
94Shigellosis_Homo sapiens_hsa051310.40321504
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38242442
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38232903
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38146486
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38110563
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37630522
100Long-term potentiation_Homo sapiens_hsa047200.37576799

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