ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.53626842
2	water-soluble vitamin biosynthetic process (GO:0042364)	4.17038305
3	fucose catabolic process (GO:0019317)	4.08102544
4	L-fucose metabolic process (GO:0042354)	4.08102544
5	L-fucose catabolic process (GO:0042355)	4.08102544
6	DNA deamination (GO:0045006)	3.86118832
7	platelet dense granule organization (GO:0060155)	3.63558806
8	kidney morphogenesis (GO:0060993)	3.51056593
9	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.47520013
10	indolalkylamine metabolic process (GO:0006586)	3.45510292
11	cellular ketone body metabolic process (GO:0046950)	3.42972913
12	indole-containing compound catabolic process (GO:0042436)	3.37702625
13	indolalkylamine catabolic process (GO:0046218)	3.37702625
14	tryptophan catabolic process (GO:0006569)	3.37702625
15	response to pheromone (GO:0019236)	3.36078657
16	respiratory chain complex IV assembly (GO:0008535)	3.35696805
17	piRNA metabolic process (GO:0034587)	3.31005174
18	axoneme assembly (GO:0035082)	3.24207261
19	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.16750350
20	negative regulation of telomere maintenance (GO:0032205)	3.14674624
21	glycerophospholipid catabolic process (GO:0046475)	3.14224112
22	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.12834870
23	ketone body metabolic process (GO:1902224)	3.12779717
24	protein complex biogenesis (GO:0070271)	3.12237094
25	tryptophan metabolic process (GO:0006568)	3.08866476
26	epithelial cilium movement (GO:0003351)	3.07480397
27	kynurenine metabolic process (GO:0070189)	3.07462154
28	retinal cone cell development (GO:0046549)	3.05537270
29	regulation of hexokinase activity (GO:1903299)	3.04717141
30	regulation of glucokinase activity (GO:0033131)	3.04717141
31	detection of light stimulus involved in sensory perception (GO:0050962)	3.03795995
32	detection of light stimulus involved in visual perception (GO:0050908)	3.03795995
33	cytochrome complex assembly (GO:0017004)	2.98725768
34	cornea development in camera-type eye (GO:0061303)	2.97685840
35	protein polyglutamylation (GO:0018095)	2.95570975
36	somite development (GO:0061053)	2.93074621
37	adaptation of signaling pathway (GO:0023058)	2.91702425
38	preassembly of GPI anchor in ER membrane (GO:0016254)	2.90538097
39	protein K6-linked ubiquitination (GO:0085020)	2.90362808
40	mitochondrial respiratory chain complex assembly (GO:0033108)	2.86632734
41	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.86509199
42	NADH dehydrogenase complex assembly (GO:0010257)	2.86509199
43	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.86509199
44	regulation of action potential (GO:0098900)	2.82996120
45	DNA methylation involved in gamete generation (GO:0043046)	2.82855826
46	neural tube formation (GO:0001841)	2.79415264
47	reflex (GO:0060004)	2.74795785
48	regulation of neurotransmitter uptake (GO:0051580)	2.70749883
49	neuron fate determination (GO:0048664)	2.68825412
50	neuronal action potential (GO:0019228)	2.68685274
51	nonmotile primary cilium assembly (GO:0035058)	2.68013563
52	indole-containing compound metabolic process (GO:0042430)	2.67606956
53	cellular biogenic amine catabolic process (GO:0042402)	2.65960451
54	amine catabolic process (GO:0009310)	2.65960451
55	photoreceptor cell development (GO:0042461)	2.63574095
56	gamma-aminobutyric acid transport (GO:0015812)	2.62873158
57	behavioral response to ethanol (GO:0048149)	2.62525739
58	cilium morphogenesis (GO:0060271)	2.61562291
59	nephron epithelium morphogenesis (GO:0072088)	2.60209893
60	nephron tubule morphogenesis (GO:0072078)	2.60209893
61	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.58895837
62	photoreceptor cell maintenance (GO:0045494)	2.57182184
63	protein K11-linked deubiquitination (GO:0035871)	2.54993931
64	neuronal action potential propagation (GO:0019227)	2.54707578
65	cilium movement (GO:0003341)	2.54459603
66	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.53576356
67	male meiosis I (GO:0007141)	2.53379761
68	protein-cofactor linkage (GO:0018065)	2.53122860
69	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.52011357
70	rRNA catabolic process (GO:0016075)	2.51498059
71	dentate gyrus development (GO:0021542)	2.51021923
72	mannosylation (GO:0097502)	2.50712918
73	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.50362609
74	recombinational repair (GO:0000725)	2.49354619
75	cilium organization (GO:0044782)	2.49314277
76	positive regulation of meiosis (GO:0045836)	2.48897097
77	double-strand break repair via homologous recombination (GO:0000724)	2.47910130
78	nucleobase catabolic process (GO:0046113)	2.47716846
79	regulation of meiosis I (GO:0060631)	2.47683363
80	rhodopsin mediated signaling pathway (GO:0016056)	2.47612143
81	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.47257331
82	synaptic transmission, cholinergic (GO:0007271)	2.45626268
83	startle response (GO:0001964)	2.45596409
84	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.44983806
85	negative regulation of systemic arterial blood pressure (GO:0003085)	2.44846606
86	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.44035260
87	pyrimidine nucleobase catabolic process (GO:0006208)	2.43202255
88	regulation of telomere maintenance (GO:0032204)	2.42673229
89	cell proliferation in forebrain (GO:0021846)	2.42325684
90	cilium assembly (GO:0042384)	2.41581978
91	dopamine transport (GO:0015872)	2.41447950
92	endocrine pancreas development (GO:0031018)	2.41171190
93	spinal cord motor neuron differentiation (GO:0021522)	2.40482266
94	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.39967470
95	dendritic spine morphogenesis (GO:0060997)	2.38186806
96	regulation of cilium movement (GO:0003352)	2.38090167
97	transmission of nerve impulse (GO:0019226)	2.37991583
98	auditory receptor cell stereocilium organization (GO:0060088)	2.37399572
99	sulfation (GO:0051923)	2.36854566
100	signal peptide processing (GO:0006465)	2.36502178

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	* ZNF274_21170338_ChIP-Seq_K562_Hela	3.57209990
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.40706936
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.02349488
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.90027889
5	VDR_22108803_ChIP-Seq_LS180_Human	2.86376079
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.82307788
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.64397213
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.63844044
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.27197750
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.20772157
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.14733242
12	FUS_26573619_Chip-Seq_HEK293_Human	2.08347268
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.07557892
14	P300_19829295_ChIP-Seq_ESCs_Human	2.02698849
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.02608609
16	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.97218988
17	TAF15_26573619_Chip-Seq_HEK293_Human	1.96974406
18	* CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.96663825
19	EWS_26573619_Chip-Seq_HEK293_Human	1.89490092
20	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.82443243
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.80028241
22	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.78967133
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.70182010
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.66113039
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.64906179
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.64589156
27	* BCAT_22108803_ChIP-Seq_LS180_Human	1.63141776
28	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.59468610
29	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.59322235
30	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.58969979
31	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.58703226
32	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.58357439
33	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.53827866
34	SMAD4_21799915_ChIP-Seq_A2780_Human	1.52800851
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.52364844
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.52292025
37	* AR_25329375_ChIP-Seq_VCAP_Human	1.50854847
38	REST_21632747_ChIP-Seq_MESCs_Mouse	1.50249608
39	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.49552315
40	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.49147293
41	STAT3_23295773_ChIP-Seq_U87_Human	1.46583690
42	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.46337478
43	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.44982177
44	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.44582084
45	* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.44190266
46	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.43229624
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.43110144
48	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.42678698
49	* TCF4_23295773_ChIP-Seq_U87_Human	1.41837510
50	IRF1_19129219_ChIP-ChIP_H3396_Human	1.41498025
51	* IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.41494180
52	* CBP_20019798_ChIP-Seq_JUKART_Human	1.41494180
53	NANOG_19829295_ChIP-Seq_ESCs_Human	1.40911957
54	SOX2_19829295_ChIP-Seq_ESCs_Human	1.40911957
55	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.39145704
56	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.39145704
57	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.35060916
58	MYC_18940864_ChIP-ChIP_HL60_Human	1.32396434
59	TCF4_22108803_ChIP-Seq_LS180_Human	1.29221543
60	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.28976637
61	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.28366446
62	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.28175601
63	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.27449483
64	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.27449483
65	* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.26526920
66	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.26493917
67	RNF2_27304074_Chip-Seq_NSC_Mouse	1.24429033
68	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.23705604
69	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.20860329
70	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.20816800
71	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.20169404
72	RUNX2_22187159_ChIP-Seq_PCA_Human	1.20055870
73	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.16298358
74	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.16060438
75	NCOR_22424771_ChIP-Seq_293T_Human	1.14517308
76	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.13273434
77	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.13184976
78	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.13043952
79	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.12468599
80	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.11468560
81	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.10250721
82	* AR_20517297_ChIP-Seq_VCAP_Human	1.10037860
83	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.09745652
84	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.09663590
85	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.09141757
86	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.08146387
87	P53_22387025_ChIP-Seq_ESCs_Mouse	1.07364004
88	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.06331411
89	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.06263734
90	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.05845977
91	CDX2_22108803_ChIP-Seq_LS180_Human	1.04544637
92	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.04261824
93	HOXB7_26014856_ChIP-Seq_BT474_Human	1.03769439
94	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02965279
95	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.02928406
96	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.00451505
97	AR_21572438_ChIP-Seq_LNCaP_Human	0.99958032
98	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.99649047
99	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.99574725
100	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.97461306

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.18708543
2	MP0002837_dystrophic_cardiac_calcinosis	3.17094492
3	MP0006292_abnormal_olfactory_placode	3.04297153
4	MP0003195_calcinosis	2.72706627
5	MP0003787_abnormal_imprinting	2.71338009
6	MP0005646_abnormal_pituitary_gland	2.71029568
7	MP0001968_abnormal_touch/_nociception	2.47615149
8	MP0002102_abnormal_ear_morphology	2.31709357
9	MP0005551_abnormal_eye_electrophysiolog	2.22151985
10	MP0003646_muscle_fatigue	2.08218120
11	MP0002876_abnormal_thyroid_physiology	2.06667835
12	MP0005645_abnormal_hypothalamus_physiol	2.04129147
13	MP0004885_abnormal_endolymph	2.01034890
14	MP0006072_abnormal_retinal_apoptosis	1.98105705
15	MP0000569_abnormal_digit_pigmentation	1.96360537
16	MP0002736_abnormal_nociception_after	1.94730925
17	MP0009745_abnormal_behavioral_response	1.91730394
18	MP0008872_abnormal_physiological_respon	1.88860021
19	MP0000631_abnormal_neuroendocrine_gland	1.84660586
20	MP0002272_abnormal_nervous_system	1.82366282
21	MP0009046_muscle_twitch	1.79329550
22	MP0002938_white_spotting	1.70491052
23	MP0008875_abnormal_xenobiotic_pharmacok	1.66067871
24	MP0003880_abnormal_central_pattern	1.64238330
25	MP0005379_endocrine/exocrine_gland_phen	1.64135319
26	MP0002638_abnormal_pupillary_reflex	1.62506385
27	MP0000372_irregular_coat_pigmentation	1.61310004
28	MP0001986_abnormal_taste_sensitivity	1.60739390
29	MP0001501_abnormal_sleep_pattern	1.60348569
30	MP0002163_abnormal_gland_morphology	1.59946785
31	MP0000427_abnormal_hair_cycle	1.57234862
32	MP0002653_abnormal_ependyma_morphology	1.55981977
33	MP0001485_abnormal_pinna_reflex	1.51635411
34	MP0004043_abnormal_pH_regulation	1.50207142
35	MP0005253_abnormal_eye_physiology	1.50026185
36	MP0004142_abnormal_muscle_tone	1.49594056
37	MP0001984_abnormal_olfaction	1.47994059
38	MP0001486_abnormal_startle_reflex	1.46666197
39	MP0003283_abnormal_digestive_organ	1.43822656
40	MP0002138_abnormal_hepatobiliary_system	1.38484919
41	MP0004147_increased_porphyrin_level	1.38256151
42	MP0004133_heterotaxia	1.37968700
43	MP0002928_abnormal_bile_duct	1.37358086
44	MP0002064_seizures	1.36296437
45	MP0005084_abnormal_gallbladder_morpholo	1.33625592
46	MP0003121_genomic_imprinting	1.32571692
47	MP0006276_abnormal_autonomic_nervous	1.32073232
48	MP0002557_abnormal_social/conspecific_i	1.32057941
49	MP0003136_yellow_coat_color	1.31062960
50	MP0003011_delayed_dark_adaptation	1.30356036
51	MP0002735_abnormal_chemical_nociception	1.29793746
52	MP0002572_abnormal_emotion/affect_behav	1.28226045
53	MP0002160_abnormal_reproductive_system	1.27886905
54	MP0005174_abnormal_tail_pigmentation	1.27027663
55	MP0005389_reproductive_system_phenotype	1.26921425
56	MP0003122_maternal_imprinting	1.24269388
57	MP0002234_abnormal_pharynx_morphology	1.23707770
58	MP0002733_abnormal_thermal_nociception	1.23157965
59	MP0005075_abnormal_melanosome_morpholog	1.21433444
60	MP0001970_abnormal_pain_threshold	1.19965927
61	MP0005386_behavior/neurological_phenoty	1.19076905
62	MP0004924_abnormal_behavior	1.19076905
63	MP0008789_abnormal_olfactory_epithelium	1.18175136
64	MP0003718_maternal_effect	1.17612096
65	MP0001529_abnormal_vocalization	1.10329506
66	MP0002067_abnormal_sensory_capabilities	1.09762876
67	MP0003635_abnormal_synaptic_transmissio	1.09169548
68	MP0002693_abnormal_pancreas_physiology	1.06347272
69	MP0005195_abnormal_posterior_eye	1.05707792
70	MP0001944_abnormal_pancreas_morphology	1.04364295
71	MP0002909_abnormal_adrenal_gland	1.04077968
72	MP0002734_abnormal_mechanical_nocicepti	1.03588150
73	MP0000383_abnormal_hair_follicle	1.02892757
74	MP0002063_abnormal_learning/memory/cond	1.02683528
75	MP0004742_abnormal_vestibular_system	1.02385122
76	MP0004145_abnormal_muscle_electrophysio	1.01948530
77	MP0001919_abnormal_reproductive_system	1.01483133
78	MP0001905_abnormal_dopamine_level	1.01475284
79	MP0010386_abnormal_urinary_bladder	0.97249795
80	MP0000015_abnormal_ear_pigmentation	0.93562635
81	MP0001764_abnormal_homeostasis	0.91555607
82	MP0003137_abnormal_impulse_conducting	0.89715911
83	MP0000026_abnormal_inner_ear	0.88177049
84	MP0000778_abnormal_nervous_system	0.87774443
85	MP0002095_abnormal_skin_pigmentation	0.86059986
86	MP0002751_abnormal_autonomic_nervous	0.85201570
87	MP0005332_abnormal_amino_acid	0.84542152
88	MP0008058_abnormal_DNA_repair	0.84485695
89	MP0001324_abnormal_eye_pigmentation	0.83793537
90	MP0005410_abnormal_fertilization	0.82794100
91	MP0002184_abnormal_innervation	0.81419348
92	MP0001502_abnormal_circadian_rhythm	0.80823521
93	MP0001963_abnormal_hearing_physiology	0.80784274
94	MP0002229_neurodegeneration	0.79533122
95	MP0002752_abnormal_somatic_nervous	0.79124236
96	MP0002277_abnormal_respiratory_mucosa	0.78749013
97	MP0004215_abnormal_myocardial_fiber	0.77753479
98	MP0005394_taste/olfaction_phenotype	0.76189755
99	MP0005499_abnormal_olfactory_system	0.76189755
100	MP0005636_abnormal_mineral_homeostasis	0.75319347

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.29094130
2	Pancreatic fibrosis (HP:0100732)	4.00358624
3	Congenital stationary night blindness (HP:0007642)	3.97316764
4	Abnormality of midbrain morphology (HP:0002418)	3.64052848
5	Molar tooth sign on MRI (HP:0002419)	3.64052848
6	True hermaphroditism (HP:0010459)	3.62010457
7	Nephronophthisis (HP:0000090)	3.58478438
8	Abnormality of the renal cortex (HP:0011035)	3.48401744
9	Abnormality of the renal medulla (HP:0100957)	3.18254866
10	Medial flaring of the eyebrow (HP:0010747)	3.02265915
11	Type II lissencephaly (HP:0007260)	2.94476629
12	Hyperventilation (HP:0002883)	2.94047622
13	Polydipsia (HP:0001959)	2.93719512
14	Abnormal drinking behavior (HP:0030082)	2.93719512
15	Pendular nystagmus (HP:0012043)	2.88538553
16	Cystic liver disease (HP:0006706)	2.83297861
17	Abolished electroretinogram (ERG) (HP:0000550)	2.65998666
18	Renal cortical cysts (HP:0000803)	2.64546097
19	Progressive cerebellar ataxia (HP:0002073)	2.60795741
20	Tubular atrophy (HP:0000092)	2.60598085
21	Gaze-evoked nystagmus (HP:0000640)	2.55336396
22	Large for gestational age (HP:0001520)	2.54051074
23	Abnormal rod and cone electroretinograms (HP:0008323)	2.48774628
24	Abnormality of the labia minora (HP:0012880)	2.46299281
25	Febrile seizures (HP:0002373)	2.43971976
26	Gait imbalance (HP:0002141)	2.41039122
27	Ketoacidosis (HP:0001993)	2.34030502
28	Hypothermia (HP:0002045)	2.33672994
29	Attenuation of retinal blood vessels (HP:0007843)	2.33200928
30	Congenital primary aphakia (HP:0007707)	2.30429180
31	Polyuria (HP:0000103)	2.29307593
32	Intestinal atresia (HP:0011100)	2.26858636
33	Sclerocornea (HP:0000647)	2.24091833
34	Furrowed tongue (HP:0000221)	2.22868328
35	Nephrogenic diabetes insipidus (HP:0009806)	2.20740942
36	Methylmalonic acidemia (HP:0002912)	2.18908748
37	Ketosis (HP:0001946)	2.18327478
38	Hypomagnesemia (HP:0002917)	2.18276087
39	Hemiparesis (HP:0001269)	2.17376175
40	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.15778248
41	Mitochondrial inheritance (HP:0001427)	2.11347068
42	Broad-based gait (HP:0002136)	2.11023821
43	Hepatic necrosis (HP:0002605)	2.10624904
44	Congenital hepatic fibrosis (HP:0002612)	2.09764153
45	Focal motor seizures (HP:0011153)	2.09140758
46	Increased corneal curvature (HP:0100692)	2.08944837
47	Keratoconus (HP:0000563)	2.08944837
48	Chronic hepatic failure (HP:0100626)	2.08376222
49	Inability to walk (HP:0002540)	2.06074185
50	Decreased central vision (HP:0007663)	2.05489375
51	Oligodactyly (hands) (HP:0001180)	2.04932860
52	Protruding tongue (HP:0010808)	2.03995547
53	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.03309728
54	Hypoplasia of the fovea (HP:0007750)	2.03309728
55	Chorioretinal atrophy (HP:0000533)	2.02952108
56	Optic nerve hypoplasia (HP:0000609)	2.02797404
57	Genetic anticipation (HP:0003743)	2.02559857
58	Anencephaly (HP:0002323)	2.02062066
59	Lissencephaly (HP:0001339)	2.00508675
60	Neoplasm of the adrenal cortex (HP:0100641)	2.00320782
61	Increased CSF lactate (HP:0002490)	1.99877698
62	Hepatocellular necrosis (HP:0001404)	1.99303212
63	Decreased circulating renin level (HP:0003351)	1.96999336
64	Bile duct proliferation (HP:0001408)	1.96500791
65	Abnormal biliary tract physiology (HP:0012439)	1.96500791
66	Methylmalonic aciduria (HP:0012120)	1.96386454
67	Genital tract atresia (HP:0001827)	1.95802124
68	Male pseudohermaphroditism (HP:0000037)	1.95662959
69	Congenital, generalized hypertrichosis (HP:0004540)	1.93704440
70	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.92877635
71	Acute necrotizing encephalopathy (HP:0006965)	1.92480296
72	Focal seizures (HP:0007359)	1.90309895
73	Progressive macrocephaly (HP:0004481)	1.89085975
74	Congenital sensorineural hearing impairment (HP:0008527)	1.88765645
75	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.88052733
76	Pachygyria (HP:0001302)	1.87969159
77	Progressive inability to walk (HP:0002505)	1.87370957
78	Dialeptic seizures (HP:0011146)	1.85364151
79	Abnormality of macular pigmentation (HP:0008002)	1.84884305
80	Postaxial foot polydactyly (HP:0001830)	1.84253716
81	Vaginal atresia (HP:0000148)	1.83233789
82	Cerebellar dysplasia (HP:0007033)	1.82324334
83	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.81626564
84	Abnormal urine output (HP:0012590)	1.81405216
85	Bony spicule pigmentary retinopathy (HP:0007737)	1.80817326
86	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.78307673
87	Abnormality of alanine metabolism (HP:0010916)	1.78307673
88	Hyperalaninemia (HP:0003348)	1.78307673
89	Lipid accumulation in hepatocytes (HP:0006561)	1.77747765
90	Severe muscular hypotonia (HP:0006829)	1.75988584
91	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.74885321
92	Absent/shortened dynein arms (HP:0200106)	1.74885321
93	Asplenia (HP:0001746)	1.74608723
94	Colon cancer (HP:0003003)	1.73980482
95	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.73143937
96	Abnormality of the fovea (HP:0000493)	1.72446535
97	Hyperglycinemia (HP:0002154)	1.71749670
98	Abnormality of urine glucose concentration (HP:0011016)	1.71233201
99	Glycosuria (HP:0003076)	1.71233201
100	Aplasia/hypoplasia of the uterus (HP:0008684)	1.70870383

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.84491143
2	CASK	2.95107806
3	ADRBK2	2.88329872
4	PINK1	2.74349904
5	MAP4K2	2.72826176
6	WNK3	2.66850698
7	BMPR1B	2.66716942
8	ZAK	2.49914871
9	GRK1	2.49297726
10	NUAK1	2.39071555
11	WNK4	1.96834337
12	TAOK3	1.96323873
13	MAPK13	1.80065844
14	OXSR1	1.77645672
15	ACVR1B	1.75331923
16	DAPK2	1.73748740
17	TNIK	1.72818084
18	INSRR	1.65545823
19	TLK1	1.60640496
20	MARK1	1.59359181
21	MAP3K4	1.57519966
22	STK39	1.47130427
23	MKNK2	1.37336600
24	TIE1	1.37209527
25	MAP2K6	1.27519776
26	STK38L	1.25698017
27	PAK3	1.24603645
28	PNCK	1.22584166
29	BRSK2	1.19199964
30	FGFR2	1.18513562
31	NTRK3	1.15743155
32	DYRK2	1.14544715
33	PLK2	1.09781097
34	PHKG1	1.09390288
35	PHKG2	1.09390288
36	PRKCG	1.05624040
37	BCKDK	0.97248154
38	VRK1	0.96190653
39	PRKCE	0.94178310
40	TXK	0.93386509
41	MAP2K7	0.92836366
42	ADRBK1	0.92173328
43	TRIM28	0.89970974
44	NTRK2	0.84596686
45	EPHA4	0.80811644
46	NLK	0.80144672
47	PLK3	0.79891373
48	WEE1	0.79767325
49	CSNK1G2	0.77993576
50	CSNK1G1	0.76343377
51	TNK2	0.70171340
52	TGFBR1	0.68105836
53	ERBB3	0.66546804
54	MAPK15	0.66101080
55	MST4	0.64820824
56	CAMKK2	0.64095888
57	CSNK1G3	0.63996162
58	IRAK1	0.62793654
59	PRKCQ	0.61916310
60	STK11	0.59847640
61	SGK2	0.59383345
62	TSSK6	0.59040494
63	PRKCI	0.58576312
64	CAMK2A	0.56141629
65	STK3	0.56117553
66	PKN1	0.53665187
67	PIK3CA	0.52868734
68	PRKCZ	0.52120928
69	PTK2B	0.51893021
70	MAP3K9	0.51128344
71	CSNK1A1	0.50074592
72	MAPKAPK5	0.47742555
73	PRKACA	0.46996319
74	NME1	0.46604546
75	PLK4	0.46280622
76	MKNK1	0.45649587
77	TEC	0.41604182
78	CSNK1A1L	0.40815508
79	VRK2	0.40578523
80	PRKG1	0.40352925
81	PLK1	0.40203122
82	KIT	0.39834002
83	FLT3	0.39465738
84	IKBKB	0.39287959
85	PRKAA1	0.39094339
86	RPS6KA5	0.39054812
87	CAMK1	0.38611329
88	CDK3	0.38066161
89	SGK494	0.37952928
90	SGK223	0.37952928
91	AKT3	0.37303370
92	MAPKAPK3	0.36588178
93	PRKAA2	0.36122035
94	CAMK2D	0.35530968
95	GRK5	0.34835328
96	PRKCA	0.34218848
97	CDK19	0.32040425
98	ATM	0.31135727
99	GRK7	0.29736886
100	OBSCN	0.27961962

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.35509127
2	Phototransduction_Homo sapiens_hsa04744	2.72570515
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.61614359
4	Protein export_Homo sapiens_hsa03060	2.57489757
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.57238619
6	Butanoate metabolism_Homo sapiens_hsa00650	2.53883062
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.43526089
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.30115152
9	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.19231088
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.10326014
11	Nicotine addiction_Homo sapiens_hsa05033	2.03123852
12	Nitrogen metabolism_Homo sapiens_hsa00910	1.99133729
13	Selenocompound metabolism_Homo sapiens_hsa00450	1.97951740
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.91296262
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.89839921
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.89498855
17	Homologous recombination_Homo sapiens_hsa03440	1.86378272
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.85304611
19	Ether lipid metabolism_Homo sapiens_hsa00565	1.76082913
20	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.73858495
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.63691570
22	Basal transcription factors_Homo sapiens_hsa03022	1.61381843
23	Caffeine metabolism_Homo sapiens_hsa00232	1.59228822
24	Insulin secretion_Homo sapiens_hsa04911	1.58865529
25	Propanoate metabolism_Homo sapiens_hsa00640	1.58764414
26	Fanconi anemia pathway_Homo sapiens_hsa03460	1.54454632
27	Parkinsons disease_Homo sapiens_hsa05012	1.41479134
28	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.38192728
29	Taste transduction_Homo sapiens_hsa04742	1.37613291
30	RNA polymerase_Homo sapiens_hsa03020	1.31996975
31	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.31344340
32	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.29840365
33	Morphine addiction_Homo sapiens_hsa05032	1.22649121
34	Olfactory transduction_Homo sapiens_hsa04740	1.21326006
35	RNA degradation_Homo sapiens_hsa03018	1.12525149
36	Sulfur metabolism_Homo sapiens_hsa00920	1.10168133
37	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.09456687
38	One carbon pool by folate_Homo sapiens_hsa00670	1.08285522
39	Peroxisome_Homo sapiens_hsa04146	1.07712555
40	Circadian entrainment_Homo sapiens_hsa04713	1.04333787
41	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.04084379
42	Cardiac muscle contraction_Homo sapiens_hsa04260	1.02954892
43	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.02579378
44	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.01660187
45	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.01159758
46	Collecting duct acid secretion_Homo sapiens_hsa04966	1.01095618
47	GABAergic synapse_Homo sapiens_hsa04727	1.00762331
48	Chemical carcinogenesis_Homo sapiens_hsa05204	0.98132283
49	Regulation of autophagy_Homo sapiens_hsa04140	0.97627140
50	Alzheimers disease_Homo sapiens_hsa05010	0.92400876
51	Retinol metabolism_Homo sapiens_hsa00830	0.92000929
52	ABC transporters_Homo sapiens_hsa02010	0.91740848
53	Serotonergic synapse_Homo sapiens_hsa04726	0.91528526
54	Salivary secretion_Homo sapiens_hsa04970	0.91158517
55	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.90736792
56	Glutamatergic synapse_Homo sapiens_hsa04724	0.89611276
57	Huntingtons disease_Homo sapiens_hsa05016	0.88903646
58	beta-Alanine metabolism_Homo sapiens_hsa00410	0.88556423
59	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.88129117
60	Fat digestion and absorption_Homo sapiens_hsa04975	0.81927555
61	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.79328942
62	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.75791021
63	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.71691441
64	Non-homologous end-joining_Homo sapiens_hsa03450	0.71480755
65	Glycerolipid metabolism_Homo sapiens_hsa00561	0.71477966
66	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.70046908
67	Histidine metabolism_Homo sapiens_hsa00340	0.70044310
68	Mineral absorption_Homo sapiens_hsa04978	0.68498076
69	Fatty acid degradation_Homo sapiens_hsa00071	0.68444977
70	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.66002131
71	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.65673509
72	Metabolic pathways_Homo sapiens_hsa01100	0.60586071
73	Type I diabetes mellitus_Homo sapiens_hsa04940	0.59603606
74	Amphetamine addiction_Homo sapiens_hsa05031	0.57526409
75	Fatty acid elongation_Homo sapiens_hsa00062	0.57363028
76	Calcium signaling pathway_Homo sapiens_hsa04020	0.57255244
77	Purine metabolism_Homo sapiens_hsa00230	0.56674666
78	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.54382707
79	Long-term depression_Homo sapiens_hsa04730	0.53138200
80	Dopaminergic synapse_Homo sapiens_hsa04728	0.52661142
81	Fatty acid metabolism_Homo sapiens_hsa01212	0.50190363
82	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.48546808
83	Steroid biosynthesis_Homo sapiens_hsa00100	0.46934763
84	Circadian rhythm_Homo sapiens_hsa04710	0.45048443
85	Renin secretion_Homo sapiens_hsa04924	0.43475927
86	cAMP signaling pathway_Homo sapiens_hsa04024	0.42496032
87	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.41443014
88	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.41350431
89	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.41284611
90	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.40522996
91	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.40430920
92	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.40344645
93	Cocaine addiction_Homo sapiens_hsa05030	0.39249653
94	Asthma_Homo sapiens_hsa05310	0.39233189
95	Pyrimidine metabolism_Homo sapiens_hsa00240	0.36970582
96	Pancreatic secretion_Homo sapiens_hsa04972	0.36933631
97	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.33212341
98	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.32831012
99	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.31860202
100	Gastric acid secretion_Homo sapiens_hsa04971	0.31648014

ZNF835

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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