ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.24978487
2	water-soluble vitamin biosynthetic process (GO:0042364)	3.93370012
3	negative regulation of mast cell activation (GO:0033004)	3.87279286
4	DNA deamination (GO:0045006)	3.69024726
5	somite development (GO:0061053)	3.63048924
6	startle response (GO:0001964)	3.52791894
7	platelet dense granule organization (GO:0060155)	3.52426775
8	reflex (GO:0060004)	3.47411949
9	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.45887581
10	neural tube formation (GO:0001841)	3.40946976
11	protein polyglutamylation (GO:0018095)	3.40128675
12	gamma-aminobutyric acid transport (GO:0015812)	3.37355970
13	axoneme assembly (GO:0035082)	3.36128679
14	indolalkylamine metabolic process (GO:0006586)	3.35587964
15	presynaptic membrane assembly (GO:0097105)	3.35286127
16	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.34325506
17	response to pheromone (GO:0019236)	3.33255408
18	kidney morphogenesis (GO:0060993)	3.30274082
19	pyrimidine nucleobase catabolic process (GO:0006208)	3.27494811
20	righting reflex (GO:0060013)	3.24683215
21	nonmotile primary cilium assembly (GO:0035058)	3.24374894
22	adaptation of signaling pathway (GO:0023058)	3.10699280
23	regulation of action potential (GO:0098900)	3.08016492
24	nucleobase catabolic process (GO:0046113)	3.07645268
25	negative regulation of telomere maintenance (GO:0032205)	3.06235980
26	regulation of glomerulus development (GO:0090192)	3.03448853
27	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	3.03359854
28	auditory receptor cell stereocilium organization (GO:0060088)	3.02075744
29	presynaptic membrane organization (GO:0097090)	3.00110217
30	positive regulation of glomerulus development (GO:0090193)	2.99942018
31	tryptophan metabolic process (GO:0006568)	2.98347451
32	protein localization to cilium (GO:0061512)	2.97428890
33	photoreceptor cell maintenance (GO:0045494)	2.95988421
34	inner ear receptor stereocilium organization (GO:0060122)	2.93618329
35	tryptophan catabolic process (GO:0006569)	2.89968762
36	indole-containing compound catabolic process (GO:0042436)	2.89968762
37	indolalkylamine catabolic process (GO:0046218)	2.89968762
38	activated T cell proliferation (GO:0050798)	2.89835072
39	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.87467887
40	protein complex biogenesis (GO:0070271)	2.87432660
41	inositol phosphate catabolic process (GO:0071545)	2.87122834
42	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.86896516
43	limb bud formation (GO:0060174)	2.86879008
44	cell proliferation in forebrain (GO:0021846)	2.86787856
45	sulfation (GO:0051923)	2.84343384
46	regulation of telomere maintenance (GO:0032204)	2.83557426
47	serotonin metabolic process (GO:0042428)	2.82974690
48	indole-containing compound metabolic process (GO:0042430)	2.81203981
49	positive regulation of cardiac muscle cell differentiation (GO:2000727)	2.78375048
50	preassembly of GPI anchor in ER membrane (GO:0016254)	2.77658466
51	primary amino compound metabolic process (GO:1901160)	2.77095860
52	neuronal action potential (GO:0019228)	2.77017874
53	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.76069547
54	regulation of memory T cell differentiation (GO:0043380)	2.75524432
55	fucose catabolic process (GO:0019317)	2.75373641
56	L-fucose metabolic process (GO:0042354)	2.75373641
57	L-fucose catabolic process (GO:0042355)	2.75373641
58	detection of light stimulus involved in visual perception (GO:0050908)	2.72748749
59	detection of light stimulus involved in sensory perception (GO:0050962)	2.72748749
60	acrosome reaction (GO:0007340)	2.71487708
61	protein K11-linked deubiquitination (GO:0035871)	2.71459931
62	dopamine transport (GO:0015872)	2.70965484
63	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.70471762
64	embryonic epithelial tube formation (GO:0001838)	2.69057958
65	GPI anchor metabolic process (GO:0006505)	2.68655596
66	piRNA metabolic process (GO:0034587)	2.67637165
67	postsynaptic membrane organization (GO:0001941)	2.64076308
68	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.62919555
69	regulation of neurotransmitter uptake (GO:0051580)	2.62514304
70	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.58381492
71	NADH dehydrogenase complex assembly (GO:0010257)	2.58381492
72	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.58381492
73	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.58228849
74	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.58228849
75	transmission of nerve impulse (GO:0019226)	2.58226323
76	cornea development in camera-type eye (GO:0061303)	2.57314982
77	cellular response to ATP (GO:0071318)	2.57294253
78	prostate gland growth (GO:0060736)	2.54974641
79	neuronal action potential propagation (GO:0019227)	2.54216937
80	cell wall macromolecule metabolic process (GO:0044036)	2.53787709
81	positive regulation of meiosis (GO:0045836)	2.53726811
82	regulation of DNA endoreduplication (GO:0032875)	2.52615399
83	mitochondrial respiratory chain complex assembly (GO:0033108)	2.51449076
84	epithelial tube formation (GO:0072175)	2.49836168
85	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.46730684
86	cilium morphogenesis (GO:0060271)	2.44778281
87	establishment of protein localization to Golgi (GO:0072600)	2.44152513
88	dentate gyrus development (GO:0021542)	2.42488156
89	thyroid hormone metabolic process (GO:0042403)	2.42472553
90	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.42296576
91	phosphatidylethanolamine metabolic process (GO:0046337)	2.42275668
92	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.41522128
93	DNA methylation involved in gamete generation (GO:0043046)	2.41055940
94	regulation of collateral sprouting (GO:0048670)	2.40490770
95	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.40039104
96	regulation of meiosis I (GO:0060631)	2.38284824
97	inositol phosphate dephosphorylation (GO:0046855)	2.38233083
98	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.38233083
99	synapsis (GO:0007129)	2.37997017
100	negative regulation of systemic arterial blood pressure (GO:0003085)	2.37777716

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.34638045
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.12604130
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.01701210
4	EZH2_22144423_ChIP-Seq_EOC_Human	2.89420734
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.72596466
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.62949660
7	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.57491973
8	VDR_22108803_ChIP-Seq_LS180_Human	2.54256847
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.51021305
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.38321117
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.36816770
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.29140763
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.25315616
14	FUS_26573619_Chip-Seq_HEK293_Human	2.18215600
15	EWS_26573619_Chip-Seq_HEK293_Human	2.17944717
16	P300_19829295_ChIP-Seq_ESCs_Human	2.13332534
17	TAF15_26573619_Chip-Seq_HEK293_Human	2.12105102
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.04616599
19	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.01770858
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.00107540
21	IRF1_19129219_ChIP-ChIP_H3396_Human	1.96752623
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.92571837
23	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.85145723
24	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.84072794
25	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.73238297
26	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.70265746
27	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.69508824
28	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.69309772
29	SMAD4_21799915_ChIP-Seq_A2780_Human	1.65883650
30	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.57912766
31	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.56867221
32	STAT3_23295773_ChIP-Seq_U87_Human	1.56771069
33	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.55821278
34	AR_25329375_ChIP-Seq_VCAP_Human	1.54594767
35	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.54574145
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.53530536
37	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.50120091
38	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.49104716
39	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.46970285
40	TCF4_23295773_ChIP-Seq_U87_Human	1.46678903
41	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.46379349
42	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.45877716
43	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.45532565
44	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.43347250
45	RNF2_27304074_Chip-Seq_NSC_Mouse	1.42361461
46	BCAT_22108803_ChIP-Seq_LS180_Human	1.41414059
47	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.39770160
48	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.38561039
49	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.38066522
50	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.37361859
51	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.37361859
52	CBP_20019798_ChIP-Seq_JUKART_Human	1.35693095
53	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.35693095
54	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.32774979
55	REST_21632747_ChIP-Seq_MESCs_Mouse	1.31869948
56	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.31533350
57	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.29078418
58	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.28076615
59	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.27561715
60	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.26355879
61	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.25547643
62	RUNX2_22187159_ChIP-Seq_PCA_Human	1.23637656
63	TCF4_22108803_ChIP-Seq_LS180_Human	1.22946711
64	TP53_22573176_ChIP-Seq_HFKS_Human	1.22569041
65	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.21243129
66	NANOG_19829295_ChIP-Seq_ESCs_Human	1.20894674
67	SOX2_19829295_ChIP-Seq_ESCs_Human	1.20894674
68	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.19443539
69	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.18324513
70	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.18036066
71	P53_22387025_ChIP-Seq_ESCs_Mouse	1.17362807
72	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.16175772
73	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.16114790
74	* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.14181738
75	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.13735721
76	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.13396976
77	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.11626243
78	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.11009414
79	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.10824117
80	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.10230194
81	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.09652977
82	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.09227818
83	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.09227818
84	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.08839410
85	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.07154470
86	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.06769633
87	CDX2_22108803_ChIP-Seq_LS180_Human	1.05885428
88	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.05310273
89	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.05105097
90	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.03933711
91	JUN_21703547_ChIP-Seq_K562_Human	1.01675687
92	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.01110153
93	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.00751828
94	AR_21572438_ChIP-Seq_LNCaP_Human	1.00483479
95	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.00091890
96	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.99733744
97	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.99563269
98	P300_18555785_Chip-Seq_ESCs_Mouse	0.99114186
99	KDM2B_26808549_Chip-Seq_REH_Human	0.99112197
100	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.97999359

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.72062051
2	MP0002102_abnormal_ear_morphology	3.70337567
3	MP0002837_dystrophic_cardiac_calcinosis	3.34563799
4	MP0008877_abnormal_DNA_methylation	3.16150139
5	MP0003787_abnormal_imprinting	3.10781440
6	MP0005646_abnormal_pituitary_gland	2.75605041
7	MP0003195_calcinosis	2.70534978
8	MP0000372_irregular_coat_pigmentation	2.66618853
9	MP0003646_muscle_fatigue	2.26586566
10	MP0001968_abnormal_touch/_nociception	2.17618974
11	MP0006072_abnormal_retinal_apoptosis	2.02406830
12	MP0005551_abnormal_eye_electrophysiolog	1.90244361
13	MP0002736_abnormal_nociception_after	1.87994875
14	MP0006292_abnormal_olfactory_placode	1.85161415
15	MP0002638_abnormal_pupillary_reflex	1.84540448
16	MP0002138_abnormal_hepatobiliary_system	1.82847005
17	MP0004885_abnormal_endolymph	1.82203118
18	MP0001986_abnormal_taste_sensitivity	1.75682092
19	MP0005645_abnormal_hypothalamus_physiol	1.70790748
20	MP0003011_delayed_dark_adaptation	1.70352314
21	MP0006276_abnormal_autonomic_nervous	1.69563617
22	MP0009046_muscle_twitch	1.64853863
23	MP0004142_abnormal_muscle_tone	1.63656369
24	MP0002272_abnormal_nervous_system	1.63256781
25	MP0000631_abnormal_neuroendocrine_gland	1.63138825
26	MP0005379_endocrine/exocrine_gland_phen	1.62881437
27	MP0009745_abnormal_behavioral_response	1.62417844
28	MP0008872_abnormal_physiological_respon	1.60765239
29	MP0005253_abnormal_eye_physiology	1.55754771
30	MP0004147_increased_porphyrin_level	1.52576767
31	MP0001486_abnormal_startle_reflex	1.48785936
32	MP0008995_early_reproductive_senescence	1.48052506
33	MP0005084_abnormal_gallbladder_morpholo	1.44174111
34	MP0003283_abnormal_digestive_organ	1.42466485
35	MP0005389_reproductive_system_phenotype	1.39719618
36	MP0002163_abnormal_gland_morphology	1.39210802
37	MP0001919_abnormal_reproductive_system	1.38633454
38	MP0002876_abnormal_thyroid_physiology	1.37022725
39	MP0003121_genomic_imprinting	1.34934213
40	MP0002653_abnormal_ependyma_morphology	1.33988171
41	MP0001485_abnormal_pinna_reflex	1.28841207
42	MP0000516_abnormal_urinary_system	1.26658847
43	MP0005367_renal/urinary_system_phenotyp	1.26658847
44	MP0004742_abnormal_vestibular_system	1.23347710
45	MP0001984_abnormal_olfaction	1.21965872
46	MP0005075_abnormal_melanosome_morpholog	1.21150788
47	MP0003724_increased_susceptibility_to	1.19820669
48	MP0002064_seizures	1.16996093
49	MP0003635_abnormal_synaptic_transmissio	1.16387819
50	MP0002928_abnormal_bile_duct	1.16382205
51	MP0002733_abnormal_thermal_nociception	1.15814421
52	MP0000569_abnormal_digit_pigmentation	1.15726982
53	MP0002734_abnormal_mechanical_nocicepti	1.15005395
54	MP0001970_abnormal_pain_threshold	1.12919868
55	MP0001764_abnormal_homeostasis	1.11571702
56	MP0003122_maternal_imprinting	1.11484408
57	MP0002735_abnormal_chemical_nociception	1.09280442
58	MP0004133_heterotaxia	1.05989223
59	MP0002751_abnormal_autonomic_nervous	1.05751770
60	MP0010386_abnormal_urinary_bladder	1.02735206
61	MP0002572_abnormal_emotion/affect_behav	1.01695661
62	MP0002557_abnormal_social/conspecific_i	1.01160795
63	MP0003567_abnormal_fetal_cardiomyocyte	1.00857690
64	MP0000383_abnormal_hair_follicle	0.99173103
65	MP0004270_analgesia	0.99159489
66	MP0001529_abnormal_vocalization	0.99132817
67	MP0002160_abnormal_reproductive_system	0.97306621
68	MP0002063_abnormal_learning/memory/cond	0.96112177
69	MP0002909_abnormal_adrenal_gland	0.95597745
70	MP0002277_abnormal_respiratory_mucosa	0.95556599
71	MP0002254_reproductive_system_inflammat	0.94996654
72	MP0004145_abnormal_muscle_electrophysio	0.94971621
73	MP0001188_hyperpigmentation	0.94849301
74	MP0003119_abnormal_digestive_system	0.94432460
75	MP0000778_abnormal_nervous_system	0.94413731
76	MP0008789_abnormal_olfactory_epithelium	0.93999299
77	MP0001501_abnormal_sleep_pattern	0.92982226
78	MP0002067_abnormal_sensory_capabilities	0.91827802
79	MP0001963_abnormal_hearing_physiology	0.91167021
80	MP0005408_hypopigmentation	0.91004636
81	MP0000427_abnormal_hair_cycle	0.88823849
82	MP0005423_abnormal_somatic_nervous	0.87243206
83	MP0000026_abnormal_inner_ear	0.87238073
84	MP0005195_abnormal_posterior_eye	0.87232542
85	MP0005670_abnormal_white_adipose	0.85506879
86	MP0002938_white_spotting	0.83318965
87	MP0002184_abnormal_innervation	0.83202766
88	MP0000049_abnormal_middle_ear	0.82461996
89	MP0001440_abnormal_grooming_behavior	0.82264043
90	MP0003938_abnormal_ear_development	0.81735803
91	MP0005410_abnormal_fertilization	0.81466149
92	MP0005386_behavior/neurological_phenoty	0.80529843
93	MP0004924_abnormal_behavior	0.80529843
94	MP0002693_abnormal_pancreas_physiology	0.80459793
95	MP0005171_absent_coat_pigmentation	0.80146730
96	MP0005174_abnormal_tail_pigmentation	0.80141795
97	MP0005187_abnormal_penis_morphology	0.79688873
98	MP0001324_abnormal_eye_pigmentation	0.79163967
99	MP0002752_abnormal_somatic_nervous	0.78899226
100	MP0003937_abnormal_limbs/digits/tail_de	0.78543184

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	3.64141860
2	Pancreatic cysts (HP:0001737)	3.63738327
3	Congenital sensorineural hearing impairment (HP:0008527)	3.49963733
4	True hermaphroditism (HP:0010459)	3.34714358
5	Nephronophthisis (HP:0000090)	3.22839571
6	Abnormality of midbrain morphology (HP:0002418)	3.18544350
7	Molar tooth sign on MRI (HP:0002419)	3.18544350
8	Pancreatic fibrosis (HP:0100732)	3.07275508
9	Medial flaring of the eyebrow (HP:0010747)	3.00683457
10	Hyperventilation (HP:0002883)	3.00276122
11	Methylmalonic acidemia (HP:0002912)	2.95754008
12	Abnormality of the renal cortex (HP:0011035)	2.93766695
13	Gaze-evoked nystagmus (HP:0000640)	2.82595237
14	Abolished electroretinogram (ERG) (HP:0000550)	2.76196902
15	Abnormality of the renal medulla (HP:0100957)	2.69734810
16	Agitation (HP:0000713)	2.69204386
17	Hemiparesis (HP:0001269)	2.58061247
18	Renal cortical cysts (HP:0000803)	2.57312653
19	Genetic anticipation (HP:0003743)	2.45609212
20	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.41441881
21	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.40660468
22	Short 1st metacarpal (HP:0010034)	2.40660468
23	Methylmalonic aciduria (HP:0012120)	2.39570549
24	Stomach cancer (HP:0012126)	2.39505107
25	Gait imbalance (HP:0002141)	2.38499417
26	Abnormal rod and cone electroretinograms (HP:0008323)	2.36578438
27	Progressive cerebellar ataxia (HP:0002073)	2.35533418
28	Chronic hepatic failure (HP:0100626)	2.34324641
29	Nephrogenic diabetes insipidus (HP:0009806)	2.33267705
30	Type II lissencephaly (HP:0007260)	2.30991273
31	Congenital primary aphakia (HP:0007707)	2.30921598
32	Attenuation of retinal blood vessels (HP:0007843)	2.28803940
33	Male pseudohermaphroditism (HP:0000037)	2.21238866
34	Aplasia/hypoplasia of the uterus (HP:0008684)	2.19987405
35	Hyperglycinemia (HP:0002154)	2.19772410
36	3-Methylglutaconic aciduria (HP:0003535)	2.19540879
37	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.18701186
38	Abnormality of the 1st metacarpal (HP:0010009)	2.14937341
39	Ketosis (HP:0001946)	2.14357315
40	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.07867320
41	Hypoplasia of the fovea (HP:0007750)	2.07867320
42	Stenosis of the external auditory canal (HP:0000402)	2.07853184
43	Keratoconus (HP:0000563)	2.07116819
44	Increased corneal curvature (HP:0100692)	2.07116819
45	Pendular nystagmus (HP:0012043)	2.03837136
46	Absent speech (HP:0001344)	2.02983112
47	Hypoplasia of the uterus (HP:0000013)	2.00458878
48	Abnormality of the labia minora (HP:0012880)	1.99682704
49	Lissencephaly (HP:0001339)	1.98636221
50	Humeroradial synostosis (HP:0003041)	1.98413822
51	Synostosis involving the elbow (HP:0003938)	1.98413822
52	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.97618264
53	Broad-based gait (HP:0002136)	1.96427399
54	Genital tract atresia (HP:0001827)	1.95867476
55	Cystic liver disease (HP:0006706)	1.94843548
56	Vaginal atresia (HP:0000148)	1.92001950
57	Tubular atrophy (HP:0000092)	1.91874483
58	Decreased circulating renin level (HP:0003351)	1.90399418
59	Hypothermia (HP:0002045)	1.89545974
60	Aplasia/Hypoplasia of the hallux (HP:0008362)	1.87149053
61	Progressive macrocephaly (HP:0004481)	1.86877603
62	Decreased central vision (HP:0007663)	1.86459903
63	Adactyly (HP:0009776)	1.85597484
64	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.84491520
65	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.84473130
66	Progressive inability to walk (HP:0002505)	1.83242189
67	Acute necrotizing encephalopathy (HP:0006965)	1.82074265
68	Abnormality of vitamin B metabolism (HP:0004340)	1.81823052
69	Concave nail (HP:0001598)	1.80214030
70	Sclerocornea (HP:0000647)	1.78855936
71	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	1.78638970
72	Postaxial hand polydactyly (HP:0001162)	1.78477614
73	Ketoacidosis (HP:0001993)	1.78117018
74	IgG deficiency (HP:0004315)	1.77682334
75	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.77608172
76	Short hallux (HP:0010109)	1.77498213
77	Specific learning disability (HP:0001328)	1.77004196
78	Fibular aplasia (HP:0002990)	1.76266334
79	Bile duct proliferation (HP:0001408)	1.76104455
80	Abnormal biliary tract physiology (HP:0012439)	1.76104455
81	Intestinal atresia (HP:0011100)	1.75508541
82	Abnormality of DNA repair (HP:0003254)	1.75097400
83	Abnormality of the nasal septum (HP:0000419)	1.74529142
84	Focal motor seizures (HP:0011153)	1.74169832
85	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.73912695
86	Inability to walk (HP:0002540)	1.73198296
87	Congenital hepatic fibrosis (HP:0002612)	1.72830880
88	Polydipsia (HP:0001959)	1.72378247
89	Abnormal drinking behavior (HP:0030082)	1.72378247
90	Poor coordination (HP:0002370)	1.72129215
91	Febrile seizures (HP:0002373)	1.69765370
92	Postaxial foot polydactyly (HP:0001830)	1.69096942
93	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.68268863
94	Absent/shortened dynein arms (HP:0200106)	1.68268863
95	Tented upper lip vermilion (HP:0010804)	1.66855561
96	Hamartoma of the eye (HP:0010568)	1.66302790
97	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.64556243
98	Furrowed tongue (HP:0000221)	1.64464984
99	Asplenia (HP:0001746)	1.63727322
100	Retinitis pigmentosa (HP:0000510)	1.63471092

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.03817041
2	MAP4K2	3.53085277
3	PINK1	2.94714770
4	WNK3	2.80317518
5	GRK1	2.75323688
6	MAP3K4	2.50492377
7	CASK	2.47819922
8	MAPK13	2.32967529
9	ACVR1B	2.09169996
10	BMPR1B	2.07909501
11	ADRBK2	1.94374803
12	INSRR	1.85614616
13	TNIK	1.79764000
14	TAOK3	1.69506626
15	MAP2K7	1.66420205
16	NUAK1	1.61806789
17	PAK3	1.59725584
18	TXK	1.53180133
19	EPHA3	1.50533759
20	PLK2	1.44955735
21	MARK1	1.42668679
22	DYRK2	1.39375618
23	CSNK1G1	1.22564218
24	BCKDK	1.16505607
25	CSNK1G2	1.14687335
26	SIK2	1.12227523
27	ERBB3	1.11174600
28	TRIM28	1.08123205
29	ZAK	1.07118867
30	PRKCE	1.04746059
31	CSNK1G3	1.00883817
32	PNCK	0.99853258
33	ADRBK1	0.98535226
34	NLK	0.95626718
35	CSNK1A1L	0.93335322
36	FGFR2	0.92231847
37	TIE1	0.91117410
38	PRKCG	0.90553047
39	SGK2	0.89330019
40	DAPK2	0.84200756
41	IKBKB	0.83833567
42	TLK1	0.83210531
43	CAMKK2	0.82282004
44	DYRK3	0.76907474
45	FER	0.76382926
46	TEC	0.75863945
47	OXSR1	0.75691587
48	PASK	0.75335402
49	BCR	0.72916029
50	FLT3	0.71697371
51	CAMK2A	0.64662314
52	PHKG1	0.63406527
53	PHKG2	0.63406527
54	IRAK1	0.63366990
55	GRK5	0.63246140
56	GRK7	0.62870867
57	PRKCQ	0.62648983
58	CSNK1A1	0.62216075
59	STK38L	0.61904312
60	SGK223	0.61845127
61	SGK494	0.61845127
62	AKT3	0.61088776
63	MST4	0.60685235
64	STK39	0.60277771
65	MAPKAPK3	0.59624248
66	WEE1	0.57963786
67	TNK2	0.57253040
68	PRKD2	0.54607198
69	STK11	0.53897041
70	TGFBR1	0.53756179
71	DYRK1A	0.53406825
72	ERBB2	0.51989111
73	PRKACA	0.51709802
74	BMPR2	0.51497999
75	NTRK2	0.51402076
76	PRKCZ	0.51352993
77	SRPK1	0.50901973
78	WNK4	0.48646020
79	MAP3K9	0.47337560
80	CAMK2B	0.46805303
81	RPS6KA5	0.46014840
82	MAP2K4	0.45176382
83	ITK	0.44835110
84	SYK	0.44174152
85	CSNK1D	0.43794473
86	SGK1	0.43181099
87	LYN	0.42360600
88	GRK6	0.42196207
89	NTRK3	0.41511788
90	IKBKE	0.39926790
91	PIK3CA	0.39079403
92	VRK1	0.38378023
93	PRKCI	0.38334255
94	PTK2B	0.37033236
95	PKN1	0.36657347
96	PLK4	0.36271411
97	MAP2K6	0.36263059
98	ABL1	0.35845508
99	NME1	0.34289842
100	PRKCA	0.33272444

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.26501221
2	Nicotine addiction_Homo sapiens_hsa05033	2.95226132
3	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.89354981
4	Phototransduction_Homo sapiens_hsa04744	2.78158463
5	Protein export_Homo sapiens_hsa03060	2.32102333
6	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.07573111
7	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.95475784
8	Oxidative phosphorylation_Homo sapiens_hsa00190	1.92235016
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.81301344
10	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.73183761
11	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.71525169
12	Propanoate metabolism_Homo sapiens_hsa00640	1.69308452
13	Collecting duct acid secretion_Homo sapiens_hsa04966	1.69057353
14	Sulfur metabolism_Homo sapiens_hsa00920	1.64515185
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.64302609
16	Morphine addiction_Homo sapiens_hsa05032	1.60252442
17	Butanoate metabolism_Homo sapiens_hsa00650	1.58329266
18	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.58132930
19	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.53394741
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.52659075
21	Ether lipid metabolism_Homo sapiens_hsa00565	1.51977159
22	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.48608178
23	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.45310718
24	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.45058754
25	Taste transduction_Homo sapiens_hsa04742	1.44844145
26	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.40726744
27	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.39160116
28	Chemical carcinogenesis_Homo sapiens_hsa05204	1.38748203
29	Fanconi anemia pathway_Homo sapiens_hsa03460	1.38610907
30	GABAergic synapse_Homo sapiens_hsa04727	1.31888744
31	Parkinsons disease_Homo sapiens_hsa05012	1.30292448
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.29255391
33	Circadian entrainment_Homo sapiens_hsa04713	1.29154988
34	Homologous recombination_Homo sapiens_hsa03440	1.28509385
35	Insulin secretion_Homo sapiens_hsa04911	1.26670473
36	RNA degradation_Homo sapiens_hsa03018	1.25971024
37	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.25631557
38	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.25352774
39	Peroxisome_Homo sapiens_hsa04146	1.23816246
40	Primary immunodeficiency_Homo sapiens_hsa05340	1.21267290
41	Olfactory transduction_Homo sapiens_hsa04740	1.20795776
42	Glutamatergic synapse_Homo sapiens_hsa04724	1.19893143
43	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.18124477
44	Basal transcription factors_Homo sapiens_hsa03022	1.16455630
45	Selenocompound metabolism_Homo sapiens_hsa00450	1.15449793
46	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.14150802
47	Regulation of autophagy_Homo sapiens_hsa04140	1.11582550
48	Retinol metabolism_Homo sapiens_hsa00830	1.06891961
49	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.06730786
50	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.05971169
51	Non-homologous end-joining_Homo sapiens_hsa03450	1.04831248
52	Serotonergic synapse_Homo sapiens_hsa04726	1.02970180
53	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.00889877
54	Caffeine metabolism_Homo sapiens_hsa00232	0.96310535
55	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.95715164
56	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.94364795
57	Alzheimers disease_Homo sapiens_hsa05010	0.93358229
58	RNA polymerase_Homo sapiens_hsa03020	0.90336960
59	Dopaminergic synapse_Homo sapiens_hsa04728	0.88794727
60	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.88249352
61	Glycerolipid metabolism_Homo sapiens_hsa00561	0.86841470
62	Cocaine addiction_Homo sapiens_hsa05030	0.86543522
63	Type II diabetes mellitus_Homo sapiens_hsa04930	0.85839061
64	Type I diabetes mellitus_Homo sapiens_hsa04940	0.83829178
65	beta-Alanine metabolism_Homo sapiens_hsa00410	0.80290931
66	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.79583735
67	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.78715453
68	Amphetamine addiction_Homo sapiens_hsa05031	0.72075158
69	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.70134347
70	Renin secretion_Homo sapiens_hsa04924	0.69015159
71	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.68399412
72	Asthma_Homo sapiens_hsa05310	0.67510806
73	ABC transporters_Homo sapiens_hsa02010	0.67012190
74	Steroid biosynthesis_Homo sapiens_hsa00100	0.66359991
75	Calcium signaling pathway_Homo sapiens_hsa04020	0.65228330
76	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.65196022
77	Salivary secretion_Homo sapiens_hsa04970	0.64268646
78	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.62800883
79	Rheumatoid arthritis_Homo sapiens_hsa05323	0.60299202
80	Axon guidance_Homo sapiens_hsa04360	0.59683667
81	Histidine metabolism_Homo sapiens_hsa00340	0.59272034
82	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.58803171
83	Graft-versus-host disease_Homo sapiens_hsa05332	0.57666215
84	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.56672936
85	Huntingtons disease_Homo sapiens_hsa05016	0.56506274
86	Cardiac muscle contraction_Homo sapiens_hsa04260	0.55907058
87	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.54922362
88	Long-term depression_Homo sapiens_hsa04730	0.53456189
89	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.52123731
90	Metabolic pathways_Homo sapiens_hsa01100	0.50546469
91	Cholinergic synapse_Homo sapiens_hsa04725	0.49264872
92	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.47971679
93	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.42895852
94	Allograft rejection_Homo sapiens_hsa05330	0.42336237
95	Purine metabolism_Homo sapiens_hsa00230	0.41527077
96	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.41213674
97	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.40655191
98	Circadian rhythm_Homo sapiens_hsa04710	0.40556293
99	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.40282232
100	Fatty acid elongation_Homo sapiens_hsa00062	0.40152919

ZNF836

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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