ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	post-embryonic morphogenesis (GO:0009886)	6.47385064
2	peptidyl-arginine omega-N-methylation (GO:0035247)	5.81786683
3	mucosal-associated lymphoid tissue development (GO:0048537)	5.61348591
4	Peyers patch development (GO:0048541)	5.61348591
5	regulation of mammary gland epithelial cell proliferation (GO:0033599)	5.45085054
6	histone H3-K36 demethylation (GO:0070544)	5.19443212
7	mature B cell differentiation involved in immune response (GO:0002313)	4.91600126
8	peptidyl-arginine N-methylation (GO:0035246)	4.85800753
9	peptidyl-arginine methylation (GO:0018216)	4.85800753
10	proline biosynthetic process (GO:0006561)	4.85284762
11	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	4.82798330
12	ribosomal small subunit biogenesis (GO:0042274)	4.73321656
13	histone arginine methylation (GO:0034969)	4.46666017
14	ribosomal small subunit assembly (GO:0000028)	4.25434119
15	regulation of monocyte differentiation (GO:0045655)	4.07247134
16	viral transcription (GO:0019083)	4.02992517
17	urea cycle (GO:0000050)	3.87382902
18	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.81309685
19	translational termination (GO:0006415)	3.64802257
20	peptidyl-histidine modification (GO:0018202)	3.62904726
21	nitrogen cycle metabolic process (GO:0071941)	3.62435844
22	negative regulation of cell size (GO:0045792)	3.58318613
23	proline metabolic process (GO:0006560)	3.57681883
24	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	3.56064762
25	protein maturation by protein folding (GO:0022417)	3.52472663
26	negative regulation of B cell apoptotic process (GO:0002903)	3.50299813
27	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	3.47797417
28	translational elongation (GO:0006414)	3.46840625
29	iron-sulfur cluster assembly (GO:0016226)	3.45986772
30	metallo-sulfur cluster assembly (GO:0031163)	3.45986772
31	urea metabolic process (GO:0019627)	3.45700324
32	maturation of SSU-rRNA (GO:0030490)	3.44959102
33	pyrimidine nucleotide catabolic process (GO:0006244)	3.36678742
34	pentose-phosphate shunt (GO:0006098)	3.34834836
35	nucleosome disassembly (GO:0006337)	3.34106007
36	protein-DNA complex disassembly (GO:0032986)	3.34106007
37	mitochondrial calcium ion transport (GO:0006851)	3.33926337
38	pentose metabolic process (GO:0019321)	3.33208038
39	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.33195080
40	viral life cycle (GO:0019058)	3.32607827
41	positive regulation of histone deacetylation (GO:0031065)	3.31979879
42	peptidyl-arginine modification (GO:0018195)	3.20963402
43	UV protection (GO:0009650)	3.18262278
44	mitotic nuclear envelope reassembly (GO:0007084)	3.14621834
45	nuclear envelope reassembly (GO:0031468)	3.14621834
46	mature B cell differentiation (GO:0002335)	3.14580719
47	viral mRNA export from host cell nucleus (GO:0046784)	3.13910736
48	regulation of telomerase activity (GO:0051972)	3.13494575
49	regulation of glucocorticoid metabolic process (GO:0031943)	3.11273692
50	glucose catabolic process (GO:0006007)	3.10917416
51	L-serine metabolic process (GO:0006563)	3.09606087
52	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.07261185
53	apoptotic process involved in morphogenesis (GO:0060561)	3.06427079
54	RNA localization (GO:0006403)	3.04817472
55	pinocytosis (GO:0006907)	3.04253032
56	regulation of hydrogen peroxide metabolic process (GO:0010310)	3.01342963
57	response to misfolded protein (GO:0051788)	3.00596764
58	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.98155318
59	cotranslational protein targeting to membrane (GO:0006613)	2.96272398
60	protein targeting to ER (GO:0045047)	2.96269066
61	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	2.94642066
62	spliceosomal tri-snRNP complex assembly (GO:0000244)	2.92345882
63	ribosome biogenesis (GO:0042254)	2.91512196
64	ribonucleoprotein complex biogenesis (GO:0022613)	2.90486621
65	negative regulation of granulocyte differentiation (GO:0030853)	2.89836975
66	NADPH regeneration (GO:0006740)	2.89136501
67	protein complex disassembly (GO:0043241)	2.88617118
68	glutamine family amino acid biosynthetic process (GO:0009084)	2.87602260
69	dosage compensation (GO:0007549)	2.87383251
70	chromatin assembly (GO:0031497)	2.86027934
71	cellular protein complex disassembly (GO:0043624)	2.85823876
72	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.83884296
73	virion assembly (GO:0019068)	2.82264112
74	seminiferous tubule development (GO:0072520)	2.81634836
75	modulation by virus of host process (GO:0019054)	2.78006974
76	oxidative phosphorylation (GO:0006119)	2.77619332
77	protein retention in ER lumen (GO:0006621)	2.76769920
78	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.76340355
79	protein localization to endoplasmic reticulum (GO:0070972)	2.74703503
80	UTP biosynthetic process (GO:0006228)	2.73928835
81	GMP metabolic process (GO:0046037)	2.73889624
82	base-excision repair, AP site formation (GO:0006285)	2.73281167
83	negative regulation of mRNA processing (GO:0050686)	2.72544167
84	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.71123183
85	protein insertion into membrane (GO:0051205)	2.70810639
86	positive regulation of protein sumoylation (GO:0033235)	2.70405858
87	3-UTR-mediated mRNA stabilization (GO:0070935)	2.70356335
88	chaperone mediated protein folding requiring cofactor (GO:0051085)	2.67905897
89	intracellular estrogen receptor signaling pathway (GO:0030520)	2.66851886
90	grooming behavior (GO:0007625)	2.66293464
91	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.65536729
92	gland morphogenesis (GO:0022612)	2.64688719
93	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	2.63582568
94	macromolecular complex disassembly (GO:0032984)	2.60886828
95	poly(A)+ mRNA export from nucleus (GO:0016973)	2.59718857
96	UTP metabolic process (GO:0046051)	2.59224499
97	regulation of chromatin binding (GO:0035561)	2.58055996
98	GTP biosynthetic process (GO:0006183)	2.56308181
99	regulation of cholesterol metabolic process (GO:0090181)	2.54752561
100	translational initiation (GO:0006413)	2.54256678

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.41674420
2	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.04726298
3	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.88387865
4	VDR_21846776_ChIP-Seq_THP-1_Human	2.71828761
5	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.66786916
6	LXR_22292898_ChIP-Seq_THP-1_Human	2.41574587
7	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.33026716
8	MYC_22102868_ChIP-Seq_BL_Human	2.32994224
9	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.14557884
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.07679973
11	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	2.04624720
12	ZNF263_19887448_ChIP-Seq_K562_Human	2.03909507
13	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.97644597
14	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.97514014
15	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.96227571
16	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.95869276
17	XRN2_22483619_ChIP-Seq_HELA_Human	1.93664949
18	P68_20966046_ChIP-Seq_HELA_Human	1.93351570
19	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.91623021
20	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.82969246
21	RACK7_27058665_Chip-Seq_MCF-7_Human	1.82423688
22	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.82068325
23	* ETS1_20019798_ChIP-Seq_JURKAT_Human	1.68457672
24	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.68383099
25	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.68311599
26	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.67256722
27	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.64395674
28	CIITA_25753668_ChIP-Seq_RAJI_Human	1.63854187
29	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.62315704
30	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.60697134
31	* GABP_19822575_ChIP-Seq_HepG2_Human	1.60642528
32	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.59755805
33	E2F7_22180533_ChIP-Seq_HELA_Human	1.56846694
34	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.51603164
35	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.50500089
36	KDM2B_26808549_Chip-Seq_DND41_Human	1.50438103
37	TCF7_22412390_ChIP-Seq_EML_Mouse	1.49006289
38	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.47194143
39	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.46754945
40	MAF_26560356_Chip-Seq_TH2_Human	1.46246566
41	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.45414696
42	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.43588811
43	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.43421516
44	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.40306006
45	BCL6_27268052_Chip-Seq_Bcells_Human	1.40291764
46	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.39224324
47	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.38543420
48	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.37472471
49	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.36181947
50	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.35730285
51	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.35426360
52	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.34705306
53	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.33773214
54	UTX_26944678_Chip-Seq_JUKART_Human	1.32730859
55	MAF_26560356_Chip-Seq_TH1_Human	1.29077419
56	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.28736803
57	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.28673096
58	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.28386021
59	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.28071062
60	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.27536636
61	BCOR_27268052_Chip-Seq_Bcells_Human	1.26341770
62	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.25976758
63	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.25863348
64	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.22136401
65	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.21662949
66	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.21226526
67	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.21167468
68	CTCF_21964334_Chip-Seq_Bcells_Human	1.19938851
69	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.18262014
70	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.17733472
71	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.16899923
72	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.16419804
73	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.15081837
74	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.14690913
75	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.14287517
76	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.13990229
77	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.13870470
78	KDM5A_27292631_Chip-Seq_BREAST_Human	1.13492763
79	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.13472459
80	SMC4_20622854_ChIP-Seq_HELA_Human	1.13109835
81	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.12512674
82	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.12107676
83	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.12075282
84	VDR_24763502_ChIP-Seq_THP-1_Human	1.11492638
85	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.10833170
86	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.10783461
87	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.10188596
88	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.08658202
89	* NCOR1_26117541_ChIP-Seq_K562_Human	1.08634773
90	CREB1_26743006_Chip-Seq_LNCaP_Human	1.07367002
91	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.07317664
92	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.07123933
93	CTCF_27219007_Chip-Seq_Bcells_Human	1.06385319
94	KDM2B_26808549_Chip-Seq_K562_Human	1.05905029
95	PHF8_20622854_ChIP-Seq_HELA_Human	1.05703530
96	ETS1_21867929_ChIP-Seq_TH2_Mouse	1.05644741
97	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.05474671
98	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.04995640
99	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.04954525
100	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.04764917

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002234_abnormal_pharynx_morphology	4.81070875
2	MP0008260_abnormal_autophagy	3.81832859
3	MP0009384_cardiac_valve_regurgitation	2.93958135
4	MP0002132_abnormal_respiratory_system	2.93199388
5	MP0005058_abnormal_lysosome_morphology	2.83267262
6	MP0002249_abnormal_larynx_morphology	2.68402364
7	MP0000678_abnormal_parathyroid_gland	2.56713801
8	MP0009379_abnormal_foot_pigmentation	2.44076180
9	MP0001661_extended_life_span	2.42750054
10	MP0002396_abnormal_hematopoietic_system	2.24323795
11	MP0003111_abnormal_nucleus_morphology	2.21092541
12	MP0009333_abnormal_splenocyte_physiolog	2.08911851
13	MP0005451_abnormal_body_composition	2.00741951
14	MP0003693_abnormal_embryo_hatching	1.97827303
15	MP0009278_abnormal_bone_marrow	1.96806944
16	MP0006292_abnormal_olfactory_placode	1.92314100
17	MP0004185_abnormal_adipocyte_glucose	1.89999200
18	MP0001849_ear_inflammation	1.79433470
19	MP0000613_abnormal_salivary_gland	1.77533490
20	MP0000681_abnormal_thyroid_gland	1.71849728
21	MP0003866_abnormal_defecation	1.71277778
22	MP0010030_abnormal_orbit_morphology	1.68759814
23	MP0000490_abnormal_crypts_of	1.65674502
24	MP0005501_abnormal_skin_physiology	1.65299326
25	MP0000566_synostosis	1.64897336
26	MP0003806_abnormal_nucleotide_metabolis	1.58090087
27	MP0003186_abnormal_redox_activity	1.50352689
28	MP0005623_abnormal_meninges_morphology	1.49500311
29	MP0002089_abnormal_postnatal_growth/wei	1.47386614
30	MP0004858_abnormal_nervous_system	1.46892233
31	MP0008058_abnormal_DNA_repair	1.44128317
32	MP0001545_abnormal_hematopoietic_system	1.43604780
33	MP0005397_hematopoietic_system_phenotyp	1.43604780
34	MP0003115_abnormal_respiratory_system	1.41665608
35	MP0008932_abnormal_embryonic_tissue	1.36273645
36	MP0010094_abnormal_chromosome_stability	1.32285647
37	MP0000465_gastrointestinal_hemorrhage	1.32047120
38	MP0002653_abnormal_ependyma_morphology	1.32042704
39	MP0003705_abnormal_hypodermis_morpholog	1.31810930
40	MP0002163_abnormal_gland_morphology	1.31119130
41	MP0005499_abnormal_olfactory_system	1.27753705
42	MP0005394_taste/olfaction_phenotype	1.27753705
43	MP0005464_abnormal_platelet_physiology	1.25198097
44	MP0002932_abnormal_joint_morphology	1.21301825
45	MP0000313_abnormal_cell_death	1.19271910
46	MP0003763_abnormal_thymus_physiology	1.18648125
47	MP0000049_abnormal_middle_ear	1.17515687
48	MP0003868_abnormal_feces_composition	1.16439755
49	MP0001664_abnormal_digestion	1.15685553
50	MP0003315_abnormal_perineum_morphology	1.12266912
51	MP0008789_abnormal_olfactory_epithelium	1.11685691
52	MP0001727_abnormal_embryo_implantation	1.08930029
53	MP0000537_abnormal_urethra_morphology	1.03698134
54	MP0001542_abnormal_bone_strength	1.03178005
55	MP0003077_abnormal_cell_cycle	1.02517709
56	MP0001919_abnormal_reproductive_system	1.01431559
57	MP0001730_embryonic_growth_arrest	0.99674623
58	MP0004381_abnormal_hair_follicle	0.98511162
59	MP0001764_abnormal_homeostasis	0.98131864
60	MP0002019_abnormal_tumor_incidence	0.96204183
61	MP0000703_abnormal_thymus_morphology	0.95362337
62	MP0003279_aneurysm	0.93983696
63	MP0005409_darkened_coat_color	0.91188343
64	MP0000350_abnormal_cell_proliferation	0.90764699
65	MP0002080_prenatal_lethality	0.87378100
66	MP0006036_abnormal_mitochondrial_physio	0.86803067
67	MP0000462_abnormal_digestive_system	0.86548550
68	MP0005508_abnormal_skeleton_morphology	0.86448861
69	MP0003303_peritoneal_inflammation	0.83761814
70	MP0005083_abnormal_biliary_tract	0.83711658
71	MP0002429_abnormal_blood_cell	0.83012697
72	MP0005076_abnormal_cell_differentiation	0.82862318
73	MP0005621_abnormal_cell_physiology	0.81278984
74	MP0002722_abnormal_immune_system	0.81230871
75	MP0003943_abnormal_hepatobiliary_system	0.81198032
76	MP0002398_abnormal_bone_marrow	0.80073674
77	MP0009053_abnormal_anal_canal	0.78056664
78	MP0001881_abnormal_mammary_gland	0.77956340
79	MP0003942_abnormal_urinary_system	0.76946865
80	MP0005666_abnormal_adipose_tissue	0.76141673
81	MP0002796_impaired_skin_barrier	0.75871256
82	MP0001790_abnormal_immune_system	0.75194926
83	MP0005387_immune_system_phenotype	0.75194926
84	MP0000750_abnormal_muscle_regeneration	0.73163279
85	MP0005330_cardiomyopathy	0.73065380
86	MP0001853_heart_inflammation	0.71595414
87	MP0004808_abnormal_hematopoietic_stem	0.70481588
88	MP0003119_abnormal_digestive_system	0.70256609
89	MP0002114_abnormal_axial_skeleton	0.70195695
90	MP0008875_abnormal_xenobiotic_pharmacok	0.70168336
91	MP0001835_abnormal_antigen_presentation	0.69766815
92	MP0000467_abnormal_esophagus_morphology	0.69639664
93	MP0001666_abnormal_nutrient_absorption	0.68778542
94	MP0002085_abnormal_embryonic_tissue	0.68463447
95	MP0005025_abnormal_response_to	0.68268527
96	MP0000858_altered_metastatic_potential	0.67700933
97	MP0002092_abnormal_eye_morphology	0.67216128
98	MP0000477_abnormal_intestine_morphology	0.66365323
99	MP0009931_abnormal_skin_appearance	0.65876352
100	MP0000689_abnormal_spleen_morphology	0.65323760

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Entropion (HP:0000621)	5.18858144
2	Increased neuronal autofluorescent lipopigment (HP:0002074)	4.74614696
3	Microvesicular hepatic steatosis (HP:0001414)	4.48021051
4	Poikiloderma (HP:0001029)	4.41264324
5	Visual hallucinations (HP:0002367)	4.25430900
6	Increased cerebral lipofuscin (HP:0011813)	4.21603466
7	Stridor (HP:0010307)	4.19362894
8	Abnormal number of erythroid precursors (HP:0012131)	3.60400154
9	Broad distal phalanx of finger (HP:0009836)	3.53291726
10	Abnormality of cells of the erythroid lineage (HP:0012130)	3.48562714
11	Thoracic kyphosis (HP:0002942)	3.08733048
12	Ragged-red muscle fibers (HP:0003200)	3.06641204
13	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	3.02058068
14	Increased muscle lipid content (HP:0009058)	3.01965635
15	Abnormality of the thoracic spine (HP:0100711)	2.99446920
16	Anomalous pulmonary venous return (HP:0010772)	2.86248346
17	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.85352809
18	Breast hypoplasia (HP:0003187)	2.76493481
19	Abnormal hair laboratory examination (HP:0003328)	2.76446194
20	Flat capital femoral epiphysis (HP:0003370)	2.74904302
21	Abnormality of the umbilical cord (HP:0010881)	2.73433864
22	Reticulocytosis (HP:0001923)	2.65790253
23	Abnormality of DNA repair (HP:0003254)	2.64454459
24	Septate vagina (HP:0001153)	2.54572272
25	Testicular atrophy (HP:0000029)	2.50203796
26	Spastic paraparesis (HP:0002313)	2.49339465
27	Abnormality of the pulmonary veins (HP:0011718)	2.48803966
28	Abnormal umbilical cord blood vessels (HP:0011403)	2.48611844
29	Single umbilical artery (HP:0001195)	2.48611844
30	Abnormality of the fetal cardiovascular system (HP:0010948)	2.48611844
31	Abnormal ventriculo-arterial connection (HP:0011563)	2.46632436
32	Transposition of the great arteries (HP:0001669)	2.46632436
33	Abnormal connection of the cardiac segments (HP:0011545)	2.46632436
34	Achilles tendon contracture (HP:0001771)	2.43020346
35	Bulbar palsy (HP:0001283)	2.42341180
36	Anteriorly placed anus (HP:0001545)	2.42181279
37	Large eyes (HP:0001090)	2.40774015
38	Dry hair (HP:0011359)	2.38448660
39	Short nail (HP:0001799)	2.35747653
40	Flattened epiphyses (HP:0003071)	2.29711464
41	Colitis (HP:0002583)	2.29628514
42	Joint stiffness (HP:0001387)	2.29547629
43	Rough bone trabeculation (HP:0100670)	2.24577678
44	Gonadal dysgenesis (HP:0000133)	2.21352748
45	Panhypogammaglobulinemia (HP:0003139)	2.20481523
46	Mesangial abnormality (HP:0001966)	2.19102084
47	Abnormality of reticulocytes (HP:0004312)	2.18661212
48	Hyperthyroidism (HP:0000836)	2.15021172
49	Vertebral compression fractures (HP:0002953)	2.14926573
50	Long palpebral fissure (HP:0000637)	2.14592513
51	Abnormality of the Achilles tendon (HP:0005109)	2.09199975
52	Hypoplastic left heart (HP:0004383)	2.09187823
53	Distal lower limb amyotrophy (HP:0008944)	2.06615225
54	Cellulitis (HP:0100658)	2.05614643
55	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.05493448
56	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.05493448
57	Long toe (HP:0010511)	2.04320175
58	Ulnar bowing (HP:0003031)	2.02747534
59	Squamous cell carcinoma (HP:0002860)	2.01977045
60	Hypertensive crisis (HP:0100735)	2.00198010
61	Rhabdomyolysis (HP:0003201)	1.95124672
62	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.94107565
63	Pili torti (HP:0003777)	1.92661232
64	Hyperacusis (HP:0010780)	1.90226435
65	Prolonged neonatal jaundice (HP:0006579)	1.89488977
66	Diaphragmatic weakness (HP:0009113)	1.89440931
67	Pseudobulbar signs (HP:0002200)	1.89384409
68	Agammaglobulinemia (HP:0004432)	1.89323647
69	Tubulointerstitial nephritis (HP:0001970)	1.88330821
70	Abnormality of the anterior horn cell (HP:0006802)	1.87579959
71	Degeneration of anterior horn cells (HP:0002398)	1.87579959
72	Ankle clonus (HP:0011448)	1.86403914
73	Atelectasis (HP:0100750)	1.86240291
74	Microretrognathia (HP:0000308)	1.84783209
75	Muscle stiffness (HP:0003552)	1.82976280
76	Flat acetabular roof (HP:0003180)	1.82748591
77	Premature skin wrinkling (HP:0100678)	1.82265918
78	Gastrointestinal inflammation (HP:0004386)	1.80856200
79	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.80700450
80	Hepatocellular necrosis (HP:0001404)	1.80334155
81	Asymmetry of the thorax (HP:0001555)	1.79649283
82	Patent foramen ovale (HP:0001655)	1.79091808
83	Abnormal vertebral ossification (HP:0100569)	1.77036665
84	Broad face (HP:0000283)	1.76315881
85	Lipid accumulation in hepatocytes (HP:0006561)	1.75867061
86	Thrombocytosis (HP:0001894)	1.75569188
87	Hepatic necrosis (HP:0002605)	1.73054146
88	Abnormality of the tricuspid valve (HP:0001702)	1.72905299
89	Increased intramyocellular lipid droplets (HP:0012240)	1.71603806
90	Opisthotonus (HP:0002179)	1.71200683
91	Supernumerary nipples (HP:0002558)	1.69885837
92	Nasal polyposis (HP:0100582)	1.69756934
93	Polygenic inheritance (HP:0010982)	1.69427400
94	Dysostosis multiplex (HP:0000943)	1.68141224
95	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	1.67424549
96	Mediastinal lymphadenopathy (HP:0100721)	1.67357041
97	Easy fatigability (HP:0003388)	1.66600679
98	Myopathic facies (HP:0002058)	1.66107412
99	Fasciculations (HP:0002380)	1.65037913
100	Testicular neoplasm (HP:0010788)	1.64160239

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	4.11789958
2	MAP3K11	4.08921917
3	TESK2	3.88769455
4	SMG1	3.79981639
5	TRIB3	3.74639493
6	VRK2	3.34261620
7	TESK1	2.55443356
8	SIK1	2.55413767
9	BCKDK	2.45514607
10	ERN1	2.35492732
11	MAP3K10	2.31078427
12	KDR	2.27857165
13	MAP4K1	1.96994292
14	PRPF4B	1.95104609
15	PIM2	1.87528332
16	PRKD3	1.71921859
17	EPHA2	1.65672122
18	IRAK3	1.61432892
19	BUB1	1.58198224
20	MAPKAPK3	1.54051491
21	CSF1R	1.45747416
22	EEF2K	1.45532748
23	AURKA	1.41022923
24	ARAF	1.33496575
25	MAP2K2	1.28092852
26	HIPK2	1.26563743
27	TAF1	1.23726967
28	TAOK2	1.20575416
29	TBK1	1.16937013
30	CDK12	1.11183352
31	BMX	1.10144809
32	PKN2	1.04193953
33	CDK4	1.04103677
34	RPS6KA2	1.01438347
35	LIMK1	0.99327088
36	FLT3	0.99118882
37	CDK7	0.98903700
38	DAPK1	0.98365695
39	MARK2	0.97774185
40	RPS6KL1	0.96155805
41	RPS6KC1	0.96155805
42	RPS6KB2	0.95635130
43	PRKD2	0.95533553
44	ICK	0.93306267
45	ATR	0.93253064
46	MAP2K3	0.91968350
47	RPS6KA4	0.87451449
48	LRRK2	0.87036114
49	BRAF	0.84637629
50	STK16	0.78808237
51	RPS6KA6	0.78563265
52	MAPK11	0.76602593
53	MAP3K8	0.71969131
54	MTOR	0.67132241
55	RPS6KA1	0.63303713
56	RPS6KA5	0.62786256
57	CHEK2	0.61505856
58	MAPK15	0.61226905
59	ILK	0.60267488
60	DAPK3	0.59521848
61	KIT	0.59085443
62	ABL2	0.56237144
63	VRK1	0.55465006
64	BTK	0.54248693
65	EPHB1	0.54088525
66	MUSK	0.53234116
67	DYRK1B	0.52408031
68	DYRK3	0.51527828
69	JAK3	0.50352198
70	IKBKB	0.49654382
71	AURKB	0.49457596
72	CSNK1G3	0.48619699
73	MAPKAPK2	0.48254471
74	CHEK1	0.47912194
75	MAP3K1	0.47658416
76	TNK2	0.45729958
77	PTK2	0.45123881
78	TTN	0.43431170
79	CDK8	0.43428663
80	NUAK1	0.42150552
81	PRKCI	0.41966761
82	IKBKE	0.40398373
83	FGFR4	0.39594138
84	MAP2K4	0.39306093
85	PLK1	0.39107225
86	TYK2	0.39030488
87	MAPK4	0.39009217
88	GRK6	0.37940694
89	PTK6	0.35513604
90	NEK2	0.34882617
91	PAK4	0.34719938
92	DMPK	0.33318867
93	PAK1	0.33087278
94	CDK9	0.32749105
95	RIPK1	0.29988275
96	SCYL2	0.28653545
97	CDK2	0.27695191
98	MAPK3	0.25630513
99	PRKD1	0.25419294
100	AKT2	0.24889671

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Sulfur relay system_Homo sapiens_hsa04122	4.44994010
2	Ribosome_Homo sapiens_hsa03010	3.84284445
3	Base excision repair_Homo sapiens_hsa03410	3.49935897
4	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	3.23289277
5	DNA replication_Homo sapiens_hsa03030	3.16883417
6	Notch signaling pathway_Homo sapiens_hsa04330	2.59657135
7	Biosynthesis of amino acids_Homo sapiens_hsa01230	2.25436295
8	Nucleotide excision repair_Homo sapiens_hsa03420	2.07667597
9	Acute myeloid leukemia_Homo sapiens_hsa05221	1.98215620
10	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.97798667
11	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.96516913
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.96061460
13	Pentose phosphate pathway_Homo sapiens_hsa00030	1.89356925
14	Fatty acid elongation_Homo sapiens_hsa00062	1.87152713
15	Spliceosome_Homo sapiens_hsa03040	1.81333779
16	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.77501690
17	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.76955272
18	Mismatch repair_Homo sapiens_hsa03430	1.58611335
19	Pyrimidine metabolism_Homo sapiens_hsa00240	1.58591509
20	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.43896524
21	Bladder cancer_Homo sapiens_hsa05219	1.38277187
22	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.29545110
23	Galactose metabolism_Homo sapiens_hsa00052	1.29484841
24	Homologous recombination_Homo sapiens_hsa03440	1.27261200
25	Carbon metabolism_Homo sapiens_hsa01200	1.21366179
26	Thyroid cancer_Homo sapiens_hsa05216	1.20663484
27	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.20537853
28	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.16437349
29	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.15839988
30	Lysosome_Homo sapiens_hsa04142	1.15092409
31	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.07737989
32	Basal cell carcinoma_Homo sapiens_hsa05217	1.04483526
33	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.04402744
34	Non-small cell lung cancer_Homo sapiens_hsa05223	1.03621450
35	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.00687463
36	HTLV-I infection_Homo sapiens_hsa05166	0.95443805
37	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.90494825
38	Phenylalanine metabolism_Homo sapiens_hsa00360	0.88406789
39	Fanconi anemia pathway_Homo sapiens_hsa03460	0.87105223
40	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.85695379
41	Other glycan degradation_Homo sapiens_hsa00511	0.85460644
42	Primary immunodeficiency_Homo sapiens_hsa05340	0.83754403
43	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.83435573
44	Viral carcinogenesis_Homo sapiens_hsa05203	0.83121255
45	Arginine biosynthesis_Homo sapiens_hsa00220	0.82689949
46	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.78069437
47	Fatty acid metabolism_Homo sapiens_hsa01212	0.77642957
48	mTOR signaling pathway_Homo sapiens_hsa04150	0.77103968
49	Cell cycle_Homo sapiens_hsa04110	0.76093933
50	Hepatitis B_Homo sapiens_hsa05161	0.74949365
51	Herpes simplex infection_Homo sapiens_hsa05168	0.72689389
52	VEGF signaling pathway_Homo sapiens_hsa04370	0.72308311
53	Endometrial cancer_Homo sapiens_hsa05213	0.71498651
54	Huntingtons disease_Homo sapiens_hsa05016	0.70609084
55	Parkinsons disease_Homo sapiens_hsa05012	0.70179419
56	AMPK signaling pathway_Homo sapiens_hsa04152	0.68444270
57	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.68371530
58	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.67795453
59	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.67716328
60	Pancreatic cancer_Homo sapiens_hsa05212	0.66610409
61	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.66187610
62	Hepatitis C_Homo sapiens_hsa05160	0.66066917
63	Peroxisome_Homo sapiens_hsa04146	0.66006380
64	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.64886366
65	RNA transport_Homo sapiens_hsa03013	0.63743454
66	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.61853971
67	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.59792891
68	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.59777880
69	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.59557081
70	mRNA surveillance pathway_Homo sapiens_hsa03015	0.58202222
71	Tyrosine metabolism_Homo sapiens_hsa00350	0.57547050
72	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.56563903
73	Purine metabolism_Homo sapiens_hsa00230	0.55005528
74	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.54272081
75	Oxidative phosphorylation_Homo sapiens_hsa00190	0.54202864
76	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.51282324
77	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.51163357
78	Antigen processing and presentation_Homo sapiens_hsa04612	0.50910776
79	Apoptosis_Homo sapiens_hsa04210	0.50795602
80	RNA polymerase_Homo sapiens_hsa03020	0.49918672
81	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.48787492
82	Alcoholism_Homo sapiens_hsa05034	0.47711239
83	Folate biosynthesis_Homo sapiens_hsa00790	0.47180826
84	Prion diseases_Homo sapiens_hsa05020	0.47037027
85	Metabolic pathways_Homo sapiens_hsa01100	0.43855851
86	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.43694489
87	Small cell lung cancer_Homo sapiens_hsa05222	0.43006461
88	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.41017029
89	Colorectal cancer_Homo sapiens_hsa05210	0.39579106
90	Glutathione metabolism_Homo sapiens_hsa00480	0.38895654
91	Arginine and proline metabolism_Homo sapiens_hsa00330	0.38692012
92	Influenza A_Homo sapiens_hsa05164	0.38536327
93	Lysine degradation_Homo sapiens_hsa00310	0.38327579
94	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.35952402
95	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.35664359
96	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.33853238
97	Endocytosis_Homo sapiens_hsa04144	0.33140136
98	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.33055886
99	Glioma_Homo sapiens_hsa05214	0.29160720
100	MicroRNAs in cancer_Homo sapiens_hsa05206	0.29061577

ZNF837

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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