ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	piRNA metabolic process (GO:0034587)	5.04711693
2	behavioral response to nicotine (GO:0035095)	4.78758817
3	DNA methylation involved in gamete generation (GO:0043046)	4.19431631
4	L-fucose metabolic process (GO:0042354)	3.73104101
5	L-fucose catabolic process (GO:0042355)	3.73104101
6	fucose catabolic process (GO:0019317)	3.73104101
7	synapsis (GO:0007129)	3.67525993
8	cilium or flagellum-dependent cell motility (GO:0001539)	3.67474852
9	indolalkylamine metabolic process (GO:0006586)	3.60713562
10	peptidyl-histidine modification (GO:0018202)	3.60470897
11	male meiosis (GO:0007140)	3.53549054
12	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.50708577
13	indole-containing compound catabolic process (GO:0042436)	3.49803164
14	indolalkylamine catabolic process (GO:0046218)	3.49803164
15	tryptophan catabolic process (GO:0006569)	3.49803164
16	tryptophan metabolic process (GO:0006568)	3.28778940
17	ubiquinone biosynthetic process (GO:0006744)	3.21181122
18	axoneme assembly (GO:0035082)	3.19371239
19	neural tube formation (GO:0001841)	3.18529090
20	male meiosis I (GO:0007141)	3.15728566
21	regulation of cilium movement (GO:0003352)	3.12732931
22	DNA deamination (GO:0045006)	3.11814205
23	detection of light stimulus involved in visual perception (GO:0050908)	3.09228474
24	detection of light stimulus involved in sensory perception (GO:0050962)	3.09228474
25	protein polyglutamylation (GO:0018095)	3.05732092
26	cellular ketone body metabolic process (GO:0046950)	3.04165624
27	epithelial cilium movement (GO:0003351)	3.03883211
28	DNA double-strand break processing (GO:0000729)	3.01475861
29	establishment of protein localization to Golgi (GO:0072600)	2.98956018
30	regulation of hippo signaling (GO:0035330)	2.98245420
31	negative regulation of cAMP-mediated signaling (GO:0043951)	2.97836112
32	histone H3-K9 methylation (GO:0051567)	2.97465483
33	photoreceptor cell maintenance (GO:0045494)	2.96082344
34	preassembly of GPI anchor in ER membrane (GO:0016254)	2.92795925
35	cilium movement (GO:0003341)	2.92365022
36	rRNA catabolic process (GO:0016075)	2.91720962
37	replication fork processing (GO:0031297)	2.90714365
38	multicellular organism reproduction (GO:0032504)	2.90601572
39	reciprocal DNA recombination (GO:0035825)	2.87581508
40	reciprocal meiotic recombination (GO:0007131)	2.87581508
41	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.82910536
42	ubiquinone metabolic process (GO:0006743)	2.82658418
43	sulfation (GO:0051923)	2.81136912
44	DNA methylation or demethylation (GO:0044728)	2.79283713
45	gene silencing by RNA (GO:0031047)	2.76849125
46	DNA demethylation (GO:0080111)	2.76796197
47	regulation of meiosis I (GO:0060631)	2.76565091
48	DNA methylation (GO:0006306)	2.74751831
49	DNA alkylation (GO:0006305)	2.74751831
50	mast cell degranulation (GO:0043303)	2.72206521
51	mast cell activation involved in immune response (GO:0002279)	2.72206521
52	DNA modification (GO:0006304)	2.70893813
53	double-strand break repair via homologous recombination (GO:0000724)	2.69830341
54	protein K63-linked deubiquitination (GO:0070536)	2.68270462
55	recombinational repair (GO:0000725)	2.67627126
56	interkinetic nuclear migration (GO:0022027)	2.67315763
57	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.67146460
58	regulation of gamma-delta T cell differentiation (GO:0045586)	2.65652127
59	negative regulation of mast cell activation (GO:0033004)	2.65621083
60	ketone body metabolic process (GO:1902224)	2.65577148
61	protein targeting to Golgi (GO:0000042)	2.64206869
62	cilium organization (GO:0044782)	2.63905955
63	protein K11-linked deubiquitination (GO:0035871)	2.63581396
64	intraciliary transport (GO:0042073)	2.62923093
65	iron-sulfur cluster assembly (GO:0016226)	2.62741180
66	metallo-sulfur cluster assembly (GO:0031163)	2.62741180
67	quinone biosynthetic process (GO:1901663)	2.61394687
68	cornea development in camera-type eye (GO:0061303)	2.61057904
69	resolution of meiotic recombination intermediates (GO:0000712)	2.60765042
70	motile cilium assembly (GO:0044458)	2.60729819
71	adenosine metabolic process (GO:0046085)	2.60633339
72	protein localization to Golgi apparatus (GO:0034067)	2.60572463
73	inositol phosphate catabolic process (GO:0071545)	2.58739004
74	cilium assembly (GO:0042384)	2.56557825
75	tRNA modification (GO:0006400)	2.55321562
76	regulation of action potential (GO:0098900)	2.55162589
77	organic cation transport (GO:0015695)	2.54314418
78	meiotic chromosome segregation (GO:0045132)	2.53447035
79	positive regulation of granulocyte differentiation (GO:0030854)	2.51648517
80	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.51504339
81	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.49698112
82	snRNA transcription (GO:0009301)	2.48756111
83	polyol catabolic process (GO:0046174)	2.46609511
84	chromosome organization involved in meiosis (GO:0070192)	2.46331177
85	protein localization to cilium (GO:0061512)	2.45954125
86	response to pheromone (GO:0019236)	2.44129860
87	mannosylation (GO:0097502)	2.43405978
88	negative regulation of telomere maintenance (GO:0032205)	2.42609699
89	indole-containing compound metabolic process (GO:0042430)	2.42261678
90	histone H4-K5 acetylation (GO:0043981)	2.40071440
91	histone H4-K8 acetylation (GO:0043982)	2.40071440
92	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.39371636
93	sperm motility (GO:0030317)	2.39086125
94	positive regulation of defense response to virus by host (GO:0002230)	2.37288095
95	lysosome localization (GO:0032418)	2.37115731
96	methionine biosynthetic process (GO:0009086)	2.36772343
97	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.36728476
98	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.35695956
99	histone H3-K9 modification (GO:0061647)	2.34228829
100	spermatid development (GO:0007286)	2.34013719

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.95685291
2	ZNF274_21170338_ChIP-Seq_K562_Hela	4.46952031
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.90832975
4	VDR_22108803_ChIP-Seq_LS180_Human	3.43510663
5	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.64782917
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.45976821
7	ER_23166858_ChIP-Seq_MCF-7_Human	2.36567872
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.35276451
9	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.29670772
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.15535304
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.04079366
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.87817788
13	EWS_26573619_Chip-Seq_HEK293_Human	1.84924140
14	EZH2_22144423_ChIP-Seq_EOC_Human	1.83213148
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.78762829
16	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.77895768
17	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.77832049
18	IRF1_19129219_ChIP-ChIP_H3396_Human	1.75991558
19	FUS_26573619_Chip-Seq_HEK293_Human	1.72680343
20	AR_21572438_ChIP-Seq_LNCaP_Human	1.69608623
21	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.65178970
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.61554766
23	* VDR_23849224_ChIP-Seq_CD4+_Human	1.57470606
24	ERA_21632823_ChIP-Seq_H3396_Human	1.55525337
25	TP53_22573176_ChIP-Seq_HFKS_Human	1.54455968
26	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.51683327
27	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.47118411
28	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.47038411
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.45342667
30	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.41442183
31	CBP_20019798_ChIP-Seq_JUKART_Human	1.41442183
32	GATA3_26560356_Chip-Seq_TH2_Human	1.41102379
33	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.40737370
34	FOXP3_21729870_ChIP-Seq_TREG_Human	1.40579684
35	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.40428827
36	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.40330187
37	CIITA_25753668_ChIP-Seq_RAJI_Human	1.38158194
38	HOXB7_26014856_ChIP-Seq_BT474_Human	1.37502757
39	BCAT_22108803_ChIP-Seq_LS180_Human	1.36096418
40	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.34837814
41	P300_19829295_ChIP-Seq_ESCs_Human	1.34561240
42	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.34187643
43	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.31656195
44	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.31656195
45	STAT3_23295773_ChIP-Seq_U87_Human	1.31090223
46	MYC_18940864_ChIP-ChIP_HL60_Human	1.27054344
47	NCOR_22424771_ChIP-Seq_293T_Human	1.26591405
48	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.25917951
49	OCT4_20526341_ChIP-Seq_ESCs_Human	1.25676001
50	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.24806733
51	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.24772298
52	NANOG_20526341_ChIP-Seq_ESCs_Human	1.24688481
53	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.23654102
54	TCF4_23295773_ChIP-Seq_U87_Human	1.20303247
55	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.20062681
56	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.20062681
57	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.19922437
58	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.19411508
59	AR_20517297_ChIP-Seq_VCAP_Human	1.17990162
60	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17335187
61	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.16419387
62	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.16253720
63	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.15203442
64	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.13005783
65	RAC3_21632823_ChIP-Seq_H3396_Human	1.12857816
66	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.11441892
67	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.11005526
68	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.10871608
69	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.10681180
70	TAF15_26573619_Chip-Seq_HEK293_Human	1.09672627
71	AR_25329375_ChIP-Seq_VCAP_Human	1.09393413
72	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.06463674
73	RUNX2_22187159_ChIP-Seq_PCA_Human	1.06359607
74	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.05635028
75	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05431450
76	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.04842577
77	GATA3_27048872_Chip-Seq_THYMUS_Human	1.04719598
78	KDM5A_27292631_Chip-Seq_BREAST_Human	1.04450993
79	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.02445550
80	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.01595182
81	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.01308142
82	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.01024367
83	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.99480627
84	MYC_19829295_ChIP-Seq_ESCs_Human	0.99413572
85	NANOG_19829295_ChIP-Seq_ESCs_Human	0.98369673
86	SOX2_19829295_ChIP-Seq_ESCs_Human	0.98369673
87	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.97552489
88	TCF4_22108803_ChIP-Seq_LS180_Human	0.97369958
89	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.97244810
90	MYB_26560356_Chip-Seq_TH2_Human	0.96790322
91	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95154672
92	RUNX_20019798_ChIP-Seq_JUKART_Human	0.93384092
93	GATA3_26560356_Chip-Seq_TH1_Human	0.89820951
94	SMAD4_21799915_ChIP-Seq_A2780_Human	0.88992492
95	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.86475761
96	GATA1_22025678_ChIP-Seq_K562_Human	0.86427698
97	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.86119770
98	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.86036649
99	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.84524373
100	P300_27268052_Chip-Seq_Bcells_Human	0.84363161

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	2.88677401
2	MP0001986_abnormal_taste_sensitivity	2.62231526
3	MP0000569_abnormal_digit_pigmentation	2.40600137
4	MP0005075_abnormal_melanosome_morpholog	2.32688590
5	MP0008058_abnormal_DNA_repair	2.32204575
6	MP0008995_early_reproductive_senescence	2.31684137
7	MP0003763_abnormal_thymus_physiology	2.15848345
8	MP0005645_abnormal_hypothalamus_physiol	2.10942726
9	MP0005174_abnormal_tail_pigmentation	2.10055909
10	MP0004381_abnormal_hair_follicle	2.02963311
11	MP0005551_abnormal_eye_electrophysiolog	2.00875967
12	MP0001968_abnormal_touch/_nociception	2.00606589
13	MP0002138_abnormal_hepatobiliary_system	1.95625944
14	MP0003646_muscle_fatigue	1.93730731
15	MP0000015_abnormal_ear_pigmentation	1.93051643
16	MP0002160_abnormal_reproductive_system	1.87986299
17	MP0002837_dystrophic_cardiac_calcinosis	1.84433794
18	MP0000427_abnormal_hair_cycle	1.81657650
19	MP0002638_abnormal_pupillary_reflex	1.81161350
20	MP0003136_yellow_coat_color	1.80291615
21	MP0005646_abnormal_pituitary_gland	1.69664866
22	MP0002102_abnormal_ear_morphology	1.68394323
23	MP0008789_abnormal_olfactory_epithelium	1.54633046
24	MP0006292_abnormal_olfactory_placode	1.50658932
25	MP0008872_abnormal_physiological_respon	1.47971782
26	MP0005389_reproductive_system_phenotype	1.46815300
27	MP0001929_abnormal_gametogenesis	1.46106871
28	MP0003698_abnormal_male_reproductive	1.45252131
29	MP0008057_abnormal_DNA_replication	1.44218272
30	MP0002132_abnormal_respiratory_system	1.43437648
31	MP0005410_abnormal_fertilization	1.41751314
32	MP0006072_abnormal_retinal_apoptosis	1.38687061
33	MP0003787_abnormal_imprinting	1.36998187
34	MP0004145_abnormal_muscle_electrophysio	1.36294114
35	MP0000631_abnormal_neuroendocrine_gland	1.34266773
36	MP0010386_abnormal_urinary_bladder	1.31723296
37	MP0001873_stomach_inflammation	1.27611332
38	MP0004043_abnormal_pH_regulation	1.27602775
39	MP0005499_abnormal_olfactory_system	1.26436654
40	MP0005394_taste/olfaction_phenotype	1.26436654
41	MP0003786_premature_aging	1.25241506
42	MP0005253_abnormal_eye_physiology	1.25054121
43	MP0000372_irregular_coat_pigmentation	1.24093045
44	MP0002210_abnormal_sex_determination	1.22842402
45	MP0006036_abnormal_mitochondrial_physio	1.22780642
46	MP0003195_calcinosis	1.21868135
47	MP0001764_abnormal_homeostasis	1.18586935
48	MP0002736_abnormal_nociception_after	1.17940925
49	MP0001984_abnormal_olfaction	1.17825688
50	MP0002876_abnormal_thyroid_physiology	1.17163849
51	MP0001501_abnormal_sleep_pattern	1.16143954
52	MP0001145_abnormal_male_reproductive	1.14939632
53	MP0010094_abnormal_chromosome_stability	1.13414500
54	MP0000653_abnormal_sex_gland	1.11634987
55	MP0001485_abnormal_pinna_reflex	1.08604824
56	MP0002095_abnormal_skin_pigmentation	1.07262098
57	MP0006276_abnormal_autonomic_nervous	1.05795065
58	MP0001919_abnormal_reproductive_system	1.04650556
59	MP0006035_abnormal_mitochondrial_morpho	1.01125202
60	MP0001800_abnormal_humoral_immune	1.00486945
61	MP0004133_heterotaxia	0.97135785
62	MP0000703_abnormal_thymus_morphology	0.96512297
63	MP0008961_abnormal_basal_metabolism	0.94479850
64	MP0008875_abnormal_xenobiotic_pharmacok	0.94131888
65	MP0000383_abnormal_hair_follicle	0.93808626
66	MP0002396_abnormal_hematopoietic_system	0.91679383
67	MP0002653_abnormal_ependyma_morphology	0.90684644
68	MP0005266_abnormal_metabolism	0.88248804
69	MP0001324_abnormal_eye_pigmentation	0.88017929
70	MP0004084_abnormal_cardiac_muscle	0.87443941
71	MP0002735_abnormal_chemical_nociception	0.84359575
72	MP0005171_absent_coat_pigmentation	0.82450183
73	MP0005220_abnormal_exocrine_pancreas	0.81312533
74	MP0000689_abnormal_spleen_morphology	0.81043408
75	MP0002254_reproductive_system_inflammat	0.80951638
76	MP0001188_hyperpigmentation	0.80921919
77	MP0009745_abnormal_behavioral_response	0.79785823
78	MP0003806_abnormal_nucleotide_metabolis	0.79342414
79	MP0002234_abnormal_pharynx_morphology	0.78326436
80	MP0002693_abnormal_pancreas_physiology	0.77723754
81	MP0001664_abnormal_digestion	0.77690104
82	MP0002127_abnormal_cardiovascular_syste	0.76058156
83	MP0002163_abnormal_gland_morphology	0.75703485
84	MP0005377_hearing/vestibular/ear_phenot	0.75438849
85	MP0003878_abnormal_ear_physiology	0.75438849
86	MP0004484_altered_response_of	0.74407797
87	MP0000230_abnormal_systemic_arterial	0.72562686
88	MP0001486_abnormal_startle_reflex	0.72009189
89	MP0002009_preneoplasia	0.71450359
90	MP0000749_muscle_degeneration	0.69998624
91	MP0000013_abnormal_adipose_tissue	0.69485014
92	MP0002277_abnormal_respiratory_mucosa	0.69466701
93	MP0003943_abnormal_hepatobiliary_system	0.69247214
94	MP0002722_abnormal_immune_system	0.69157185
95	MP0001119_abnormal_female_reproductive	0.68858342
96	MP0002928_abnormal_bile_duct	0.68766967
97	MP0001661_extended_life_span	0.68665153
98	MP0009697_abnormal_copulation	0.66882398
99	MP0009046_muscle_twitch	0.66613426
100	MP0002723_abnormal_immune_serum	0.66247079

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.46620532
2	Type II lissencephaly (HP:0007260)	3.85612400
3	Molar tooth sign on MRI (HP:0002419)	3.77321951
4	Abnormality of midbrain morphology (HP:0002418)	3.77321951
5	True hermaphroditism (HP:0010459)	3.74222162
6	Nephronophthisis (HP:0000090)	3.54678580
7	Chronic hepatic failure (HP:0100626)	3.49004862
8	Pancreatic fibrosis (HP:0100732)	3.44251413
9	Abnormality of the renal cortex (HP:0011035)	3.18412412
10	Cerebellar dysplasia (HP:0007033)	3.16189665
11	Congenital stationary night blindness (HP:0007642)	3.15341828
12	Abnormality of the renal medulla (HP:0100957)	3.06277432
13	Attenuation of retinal blood vessels (HP:0007843)	3.00247153
14	Panhypogammaglobulinemia (HP:0003139)	2.93645133
15	Hypoplasia of the pons (HP:0012110)	2.86068338
16	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.84438902
17	Abolished electroretinogram (ERG) (HP:0000550)	2.77319816
18	Retinal dysplasia (HP:0007973)	2.74675083
19	Abnormal rod and cone electroretinograms (HP:0008323)	2.73578593
20	Stomach cancer (HP:0012126)	2.72433181
21	Cystic liver disease (HP:0006706)	2.71736060
22	Protruding tongue (HP:0010808)	2.69058147
23	Abnormality of the pons (HP:0007361)	2.63507801
24	Medial flaring of the eyebrow (HP:0010747)	2.57990213
25	Clumsiness (HP:0002312)	2.50858129
26	Abnormality of DNA repair (HP:0003254)	2.48183302
27	Abnormal respiratory motile cilium morphology (HP:0005938)	2.43894882
28	Abnormal respiratory epithelium morphology (HP:0012253)	2.43894882
29	Polydipsia (HP:0001959)	2.42467503
30	Abnormal drinking behavior (HP:0030082)	2.42467503
31	Abnormality of B cell number (HP:0010975)	2.40518224
32	Renal cortical cysts (HP:0000803)	2.31937141
33	Tubular atrophy (HP:0000092)	2.31684892
34	Abnormal biliary tract physiology (HP:0012439)	2.29635325
35	Bile duct proliferation (HP:0001408)	2.29635325
36	Anencephaly (HP:0002323)	2.27309713
37	Male pseudohermaphroditism (HP:0000037)	2.27135562
38	Abnormal ciliary motility (HP:0012262)	2.23580572
39	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.21656173
40	Lissencephaly (HP:0001339)	2.21527225
41	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.16595357
42	Ketosis (HP:0001946)	2.16418500
43	Inability to walk (HP:0002540)	2.15733598
44	Congenital hepatic fibrosis (HP:0002612)	2.12901182
45	Gaze-evoked nystagmus (HP:0000640)	2.09930594
46	Abnormality of the columella (HP:0009929)	2.04749518
47	Chromsome breakage (HP:0040012)	2.04503722
48	Stomatitis (HP:0010280)	2.04341992
49	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.03608264
50	Acute lymphatic leukemia (HP:0006721)	2.03283977
51	Reduced antithrombin III activity (HP:0001976)	2.02129627
52	Abnormality of the ileum (HP:0001549)	2.00658138
53	Hyperglycinemia (HP:0002154)	2.00396652
54	Sclerocornea (HP:0000647)	1.96386574
55	Concave nail (HP:0001598)	1.95107511
56	Hypoplastic iliac wings (HP:0002866)	1.94982630
57	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.93930054
58	Abnormality of alanine metabolism (HP:0010916)	1.93930054
59	Hyperalaninemia (HP:0003348)	1.93930054
60	Nephrogenic diabetes insipidus (HP:0009806)	1.93137180
61	Absent/shortened dynein arms (HP:0200106)	1.92608454
62	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.92608454
63	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.91016945
64	Pendular nystagmus (HP:0012043)	1.90501001
65	Small hand (HP:0200055)	1.89736512
66	Abnormal protein glycosylation (HP:0012346)	1.89610755
67	Abnormal glycosylation (HP:0012345)	1.89610755
68	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.89610755
69	Abnormal protein N-linked glycosylation (HP:0012347)	1.89610755
70	Abnormal respiratory motile cilium physiology (HP:0012261)	1.89571048
71	B lymphocytopenia (HP:0010976)	1.87955739
72	Sloping forehead (HP:0000340)	1.87254369
73	Meckel diverticulum (HP:0002245)	1.86804874
74	Asplenia (HP:0001746)	1.85719323
75	Postaxial foot polydactyly (HP:0001830)	1.85653046
76	Occipital encephalocele (HP:0002085)	1.85358523
77	Bony spicule pigmentary retinopathy (HP:0007737)	1.85251788
78	Clubbing of toes (HP:0100760)	1.84888156
79	Genetic anticipation (HP:0003743)	1.84811999
80	Thyroiditis (HP:0100646)	1.84315463
81	Hyperventilation (HP:0002883)	1.83185489
82	Abnormality of the renal collecting system (HP:0004742)	1.81930185
83	IgG deficiency (HP:0004315)	1.79472750
84	Absent thumb (HP:0009777)	1.78554442
85	Polyuria (HP:0000103)	1.78293471
86	Progressive inability to walk (HP:0002505)	1.76325308
87	Severe muscular hypotonia (HP:0006829)	1.75942639
88	Neoplasm of the adrenal cortex (HP:0100641)	1.73694420
89	Furrowed tongue (HP:0000221)	1.72428451
90	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.72130614
91	Duplicated collecting system (HP:0000081)	1.72034272
92	Hyperglycinuria (HP:0003108)	1.71697675
93	Large for gestational age (HP:0001520)	1.70855403
94	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.70447002
95	Eosinophilia (HP:0001880)	1.70245905
96	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.69085199
97	Congenital primary aphakia (HP:0007707)	1.67804120
98	Hypoproteinemia (HP:0003075)	1.65114412
99	Abnormality of the preputium (HP:0100587)	1.65086347
100	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.64134600

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.36143219
2	PINK1	3.40706124
3	ZAK	3.39676925
4	MARK3	2.75800819
5	TLK1	2.49900956
6	NUAK1	2.26908556
7	BMPR1B	2.26766671
8	INSRR	2.24737181
9	ADRBK2	2.24574141
10	TAOK3	2.18572520
11	TNK2	2.17713995
12	MAP4K2	2.15026677
13	TRIM28	2.08691341
14	OBSCN	2.08569648
15	LATS1	1.91199121
16	TXK	1.90130671
17	EIF2AK3	1.62428945
18	MAP3K4	1.62255562
19	GRK1	1.55063512
20	NLK	1.41914081
21	MAPK13	1.40787602
22	MAP2K7	1.33654867
23	ACVR1B	1.33264175
24	WNK4	1.26588356
25	WNK3	1.26224713
26	MAP2K6	1.26087618
27	MAP4K1	1.12877594
28	STK38L	1.10070573
29	BTK	1.09504044
30	MAP3K7	1.05254995
31	TEC	1.03338077
32	MUSK	1.02806410
33	CSNK1G1	1.01651053
34	CSNK1A1L	0.99052921
35	GRK6	0.98677070
36	ITK	0.97880471
37	MAP2K2	0.97549238
38	PHKG1	0.95553928
39	PHKG2	0.95553928
40	FGFR2	0.94259619
41	PRKCQ	0.93940358
42	NME1	0.93674710
43	CSNK1G3	0.91313665
44	PTK2B	0.90713127
45	RPS6KA5	0.89282871
46	IKBKE	0.85947394
47	CDK3	0.85826997
48	FES	0.80247715
49	IKBKB	0.79164002
50	IRAK2	0.78724176
51	MAPK12	0.76838937
52	IRAK1	0.75905065
53	CASK	0.74539890
54	OXSR1	0.73917875
55	CAMKK2	0.71627414
56	AKT3	0.69832721
57	PRKCI	0.69658330
58	SYK	0.68049737
59	STK11	0.67459584
60	MAPKAPK3	0.61741713
61	CSNK1G2	0.61405473
62	MKNK2	0.61043470
63	MAP2K3	0.58846791
64	CAMK4	0.58818830
65	STK39	0.58790980
66	KIT	0.58415065
67	ATR	0.58363763
68	MAP2K4	0.58044594
69	DYRK3	0.57752452
70	VRK1	0.57565476
71	NEK2	0.56355536
72	CDK19	0.56196608
73	STK38	0.56087056
74	BRSK2	0.55474909
75	CHUK	0.55198672
76	RPS6KA6	0.54863711
77	EEF2K	0.53244488
78	SIK2	0.52257458
79	FLT3	0.51885532
80	ADRBK1	0.51179911
81	HCK	0.50399887
82	PRKAA2	0.48217231
83	PRKAA1	0.47849928
84	PKN2	0.47645770
85	PIM1	0.47619851
86	CAMK1	0.46520119
87	MAPK15	0.46142169
88	PAK3	0.45335324
89	ATM	0.45086813
90	CHEK2	0.43543324
91	RPS6KB1	0.42893944
92	BCKDK	0.42314003
93	LCK	0.39766006
94	PRKD2	0.39208567
95	CSNK1D	0.37974239
96	LYN	0.36985189
97	DYRK2	0.34802048
98	CDK8	0.33932882
99	PRKCE	0.33876789
100	MAPK11	0.33750044

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.04065953
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.73935945
3	Butanoate metabolism_Homo sapiens_hsa00650	2.65391058
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.50204871
5	Fanconi anemia pathway_Homo sapiens_hsa03460	2.48064865
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.42792706
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.42303325
8	Primary immunodeficiency_Homo sapiens_hsa05340	2.35057473
9	Basal transcription factors_Homo sapiens_hsa03022	2.32253525
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.29759654
11	Homologous recombination_Homo sapiens_hsa03440	2.28934278
12	Nitrogen metabolism_Homo sapiens_hsa00910	2.23152502
13	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.17856472
14	Selenocompound metabolism_Homo sapiens_hsa00450	2.06949080
15	Regulation of autophagy_Homo sapiens_hsa04140	1.97622487
16	Olfactory transduction_Homo sapiens_hsa04740	1.96128925
17	ABC transporters_Homo sapiens_hsa02010	1.87924339
18	One carbon pool by folate_Homo sapiens_hsa00670	1.62073464
19	Ether lipid metabolism_Homo sapiens_hsa00565	1.56894489
20	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.50290894
21	Taste transduction_Homo sapiens_hsa04742	1.49216815
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.48782158
23	Propanoate metabolism_Homo sapiens_hsa00640	1.40164945
24	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.38828143
25	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.38052414
26	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.37554749
27	Caffeine metabolism_Homo sapiens_hsa00232	1.28220357
28	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.26995446
29	RNA degradation_Homo sapiens_hsa03018	1.25055897
30	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.20107884
31	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.18468525
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.16498217
33	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.14848647
34	RNA polymerase_Homo sapiens_hsa03020	1.13038385
35	Tryptophan metabolism_Homo sapiens_hsa00380	1.11497086
36	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.09182884
37	Chemical carcinogenesis_Homo sapiens_hsa05204	1.08325170
38	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.07637030
39	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.01169582
40	Non-homologous end-joining_Homo sapiens_hsa03450	0.99996337
41	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.99914121
42	Peroxisome_Homo sapiens_hsa04146	0.97175117
43	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.96154772
44	Calcium signaling pathway_Homo sapiens_hsa04020	0.95837125
45	Lysine degradation_Homo sapiens_hsa00310	0.88116215
46	Circadian rhythm_Homo sapiens_hsa04710	0.87437995
47	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.87046150
48	Purine metabolism_Homo sapiens_hsa00230	0.86630187
49	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.81864098
50	Base excision repair_Homo sapiens_hsa03410	0.81303076
51	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.80080555
52	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.77301049
53	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.75658661
54	Pyrimidine metabolism_Homo sapiens_hsa00240	0.75393115
55	Circadian entrainment_Homo sapiens_hsa04713	0.74744733
56	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.73262023
57	Salivary secretion_Homo sapiens_hsa04970	0.71438748
58	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.71413317
59	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.70976287
60	Asthma_Homo sapiens_hsa05310	0.69573436
61	Nucleotide excision repair_Homo sapiens_hsa03420	0.66687167
62	mTOR signaling pathway_Homo sapiens_hsa04150	0.66508894
63	Nicotine addiction_Homo sapiens_hsa05033	0.65353014
64	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.65217861
65	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.64692636
66	beta-Alanine metabolism_Homo sapiens_hsa00410	0.63304671
67	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.62256629
68	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.60906133
69	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.58005555
70	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.57807488
71	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.55539090
72	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.55232324
73	Glycerolipid metabolism_Homo sapiens_hsa00561	0.53606226
74	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.53020190
75	RNA transport_Homo sapiens_hsa03013	0.52819250
76	Alcoholism_Homo sapiens_hsa05034	0.51672322
77	Type I diabetes mellitus_Homo sapiens_hsa04940	0.49077454
78	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.48485039
79	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.48234968
80	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.47956512
81	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.45094223
82	Platelet activation_Homo sapiens_hsa04611	0.44657861
83	Graft-versus-host disease_Homo sapiens_hsa05332	0.43568438
84	Metabolic pathways_Homo sapiens_hsa01100	0.42450720
85	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.42373227
86	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.42084424
87	Retinol metabolism_Homo sapiens_hsa00830	0.41638825
88	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.41111546
89	Morphine addiction_Homo sapiens_hsa05032	0.40872747
90	Insulin resistance_Homo sapiens_hsa04931	0.40436751
91	Allograft rejection_Homo sapiens_hsa05330	0.40270398
92	Serotonergic synapse_Homo sapiens_hsa04726	0.40252496
93	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.39812933
94	Choline metabolism in cancer_Homo sapiens_hsa05231	0.39451226
95	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.38966094
96	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.37955445
97	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.35422781
98	Glucagon signaling pathway_Homo sapiens_hsa04922	0.35162792
99	Sphingolipid metabolism_Homo sapiens_hsa00600	0.35152663
100	Herpes simplex infection_Homo sapiens_hsa05168	0.34870209

ZNF839

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »