ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	6.13562436
2	positive regulation of amino acid transport (GO:0051957)	4.63331831
3	aggressive behavior (GO:0002118)	4.53638443
4	water-soluble vitamin biosynthetic process (GO:0042364)	4.28998637
5	pyrimidine nucleobase catabolic process (GO:0006208)	4.14921450
6	single strand break repair (GO:0000012)	4.10823601
7	DNA double-strand break processing (GO:0000729)	3.99335623
8	positive regulation of vascular permeability (GO:0043117)	3.69187055
9	regulation of transmission of nerve impulse (GO:0051969)	3.62897915
10	cellular ketone body metabolic process (GO:0046950)	3.58445330
11	iron-sulfur cluster assembly (GO:0016226)	3.56734687
12	metallo-sulfur cluster assembly (GO:0031163)	3.56734687
13	cullin deneddylation (GO:0010388)	3.56229759
14	presynaptic membrane assembly (GO:0097105)	3.52845508
15	negative regulation of neurological system process (GO:0031645)	3.43357363
16	protein deneddylation (GO:0000338)	3.42148029
17	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	3.40571545
18	regulation of feeding behavior (GO:0060259)	3.37875380
19	nucleobase catabolic process (GO:0046113)	3.29436510
20	presynaptic membrane organization (GO:0097090)	3.27977617
21	intraciliary transport (GO:0042073)	3.19079363
22	regulation of glutamate secretion (GO:0014048)	3.17448834
23	auditory behavior (GO:0031223)	3.15407663
24	negative regulation of response to food (GO:0032096)	3.14594405
25	negative regulation of appetite (GO:0032099)	3.14594405
26	ketone body metabolic process (GO:1902224)	3.14149417
27	hyperosmotic salinity response (GO:0042538)	3.08804107
28	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.06001260
29	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.06001260
30	NADH dehydrogenase complex assembly (GO:0010257)	3.06001260
31	negative regulation of DNA recombination (GO:0045910)	3.04738342
32	olfactory bulb development (GO:0021772)	3.01751425
33	branched-chain amino acid catabolic process (GO:0009083)	2.97411299
34	righting reflex (GO:0060013)	2.96872620
35	regulation of response to food (GO:0032095)	2.94951204
36	protein complex biogenesis (GO:0070271)	2.92368128
37	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.89542656
38	glycosphingolipid biosynthetic process (GO:0006688)	2.86457423
39	regulation of timing of cell differentiation (GO:0048505)	2.84147949
40	negative regulation of mast cell activation (GO:0033004)	2.80444474
41	regulation of appetite (GO:0032098)	2.80287662
42	cilium morphogenesis (GO:0060271)	2.77729846
43	regulation of development, heterochronic (GO:0040034)	2.76948130
44	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.76009837
45	response to auditory stimulus (GO:0010996)	2.72836731
46	proteasome assembly (GO:0043248)	2.72030006
47	mitochondrial respiratory chain complex assembly (GO:0033108)	2.71601409
48	negative regulation of activin receptor signaling pathway (GO:0032926)	2.71472989
49	tachykinin receptor signaling pathway (GO:0007217)	2.71360662
50	mechanosensory behavior (GO:0007638)	2.70587716
51	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.69142378
52	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.69115789
53	chaperone-mediated protein transport (GO:0072321)	2.67460385
54	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.66851665
55	peptidyl-histidine modification (GO:0018202)	2.66161316
56	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.66059788
57	DNA ligation (GO:0006266)	2.65757260
58	xenobiotic catabolic process (GO:0042178)	2.61304504
59	drinking behavior (GO:0042756)	2.59247991
60	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.59236648
61	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.59236648
62	parental behavior (GO:0060746)	2.58970571
63	prostate gland growth (GO:0060736)	2.58925126
64	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.57445521
65	histone H2A acetylation (GO:0043968)	2.57086929
66	acrosome reaction (GO:0007340)	2.56593553
67	calcium ion import (GO:0070509)	2.56465071
68	replication fork processing (GO:0031297)	2.55387031
69	translesion synthesis (GO:0019985)	2.54892176
70	non-recombinational repair (GO:0000726)	2.54183781
71	double-strand break repair via nonhomologous end joining (GO:0006303)	2.54183781
72	gamma-aminobutyric acid transport (GO:0015812)	2.52751493
73	synapse assembly (GO:0007416)	2.51599373
74	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	2.51092453
75	behavioral response to nicotine (GO:0035095)	2.50809423
76	signal peptide processing (GO:0006465)	2.50736158
77	negative regulation of cell aging (GO:0090344)	2.50689120
78	respiratory chain complex IV assembly (GO:0008535)	2.50500100
79	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.50486350
80	epithelial cilium movement (GO:0003351)	2.50139460
81	establishment of integrated proviral latency (GO:0075713)	2.49733366
82	maternal behavior (GO:0042711)	2.49216352
83	C-terminal protein lipidation (GO:0006501)	2.48955711
84	GPI anchor metabolic process (GO:0006505)	2.47506807
85	glycerophospholipid catabolic process (GO:0046475)	2.46854675
86	recombinational repair (GO:0000725)	2.45832364
87	positive regulation of organic acid transport (GO:0032892)	2.45589714
88	inositol phosphate catabolic process (GO:0071545)	2.45585155
89	regulation of male gonad development (GO:2000018)	2.45547663
90	regulation of meiosis I (GO:0060631)	2.44784721
91	establishment of mitochondrion localization (GO:0051654)	2.43586114
92	axoneme assembly (GO:0035082)	2.41903594
93	pteridine-containing compound biosynthetic process (GO:0042559)	2.41900984
94	platelet dense granule organization (GO:0060155)	2.41351605
95	cytochrome complex assembly (GO:0017004)	2.40500390
96	regulation of telomere maintenance (GO:0032204)	2.40384103
97	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.40221658
98	adult feeding behavior (GO:0008343)	2.39167901
99	reflex (GO:0060004)	2.38964800
100	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.38637128

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.01970572
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.78029031
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.59967726
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.02358115
5	TAF15_26573619_Chip-Seq_HEK293_Human	2.86249965
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.80143303
7	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.75552112
8	FUS_26573619_Chip-Seq_HEK293_Human	2.73598643
9	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.69571705
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.66910860
11	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.63670804
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.55934330
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.31871364
14	P300_19829295_ChIP-Seq_ESCs_Human	2.29658035
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.14562101
16	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.13162274
17	EWS_26573619_Chip-Seq_HEK293_Human	2.01639914
18	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.98036831
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.97391126
20	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.94766403
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.90398837
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.81239043
23	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.80112107
24	ELK1_19687146_ChIP-ChIP_HELA_Human	1.78118864
25	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.72650425
26	SMAD4_21799915_ChIP-Seq_A2780_Human	1.69710609
27	EZH2_22144423_ChIP-Seq_EOC_Human	1.65428793
28	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.64346163
29	VDR_22108803_ChIP-Seq_LS180_Human	1.64171575
30	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.61360815
31	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.58564671
32	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.55176747
33	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.52711062
34	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.52588319
35	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.52373325
36	ER_23166858_ChIP-Seq_MCF-7_Human	1.51378038
37	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.49629375
38	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.48904750
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.48904750
40	AR_25329375_ChIP-Seq_VCAP_Human	1.48500288
41	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.46924609
42	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.44036648
43	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.40082926
44	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.39397118
45	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.39307291
46	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.38140414
47	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.37368425
48	NANOG_19829295_ChIP-Seq_ESCs_Human	1.36540889
49	SOX2_19829295_ChIP-Seq_ESCs_Human	1.36540889
50	STAT3_23295773_ChIP-Seq_U87_Human	1.35527567
51	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.32325901
52	RNF2_27304074_Chip-Seq_NSC_Mouse	1.23400336
53	VDR_23849224_ChIP-Seq_CD4+_Human	1.22870885
54	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.22220547
55	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.22191216
56	RUNX2_22187159_ChIP-Seq_PCA_Human	1.21815740
57	IRF1_19129219_ChIP-ChIP_H3396_Human	1.21262510
58	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.20691612
59	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.20143522
60	REST_21632747_ChIP-Seq_MESCs_Mouse	1.19918064
61	HTT_18923047_ChIP-ChIP_STHdh_Human	1.19879880
62	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.19732763
63	TCF4_22108803_ChIP-Seq_LS180_Human	1.19408729
64	TP53_22573176_ChIP-Seq_HFKS_Human	1.19227615
65	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.19130658
66	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.19125548
67	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.18998136
68	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.18994159
69	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.18985041
70	BCAT_22108803_ChIP-Seq_LS180_Human	1.18808887
71	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.18702028
72	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.16831557
73	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.16656235
74	TCF4_23295773_ChIP-Seq_U87_Human	1.15764285
75	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.15241482
76	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.13309937
77	MYC_18940864_ChIP-ChIP_HL60_Human	1.12386619
78	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.10687015
79	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.10195287
80	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.09975142
81	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.08028373
82	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.08022485
83	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.07421988
84	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.07231251
85	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.03706382
86	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.02701362
87	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.02252260
88	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.02206762
89	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.00878070
90	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.99204258
91	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.98809737
92	P53_22387025_ChIP-Seq_ESCs_Mouse	0.98641350
93	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.97936596
94	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.96516618
95	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.96299951
96	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.96266076
97	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.96266076
98	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.96231424
99	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.95924644
100	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.95324324

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001529_abnormal_vocalization	3.39342999
2	MP0005645_abnormal_hypothalamus_physiol	3.11319273
3	MP0002102_abnormal_ear_morphology	3.11305243
4	MP0002736_abnormal_nociception_after	3.00152716
5	MP0008058_abnormal_DNA_repair	2.66366971
6	MP0000569_abnormal_digit_pigmentation	2.53593218
7	MP0001968_abnormal_touch/_nociception	2.52621710
8	MP0001984_abnormal_olfaction	2.45234427
9	MP0002822_catalepsy	2.41651580
10	MP0002735_abnormal_chemical_nociception	2.29348465
11	MP0003880_abnormal_central_pattern	2.24575142
12	MP0009780_abnormal_chondrocyte_physiolo	2.23279166
13	MP0008877_abnormal_DNA_methylation	2.15969954
14	MP0008789_abnormal_olfactory_epithelium	2.09156323
15	MP0003787_abnormal_imprinting	2.06811005
16	MP0002234_abnormal_pharynx_morphology	2.06429231
17	MP0003122_maternal_imprinting	2.04385482
18	MP0003718_maternal_effect	2.01392310
19	MP0006292_abnormal_olfactory_placode	1.98047089
20	MP0009046_muscle_twitch	1.94425067
21	MP0004859_abnormal_synaptic_plasticity	1.90254670
22	MP0002734_abnormal_mechanical_nocicepti	1.87254463
23	MP0005394_taste/olfaction_phenotype	1.83446264
24	MP0005499_abnormal_olfactory_system	1.83446264
25	MP0008057_abnormal_DNA_replication	1.81966702
26	MP0002638_abnormal_pupillary_reflex	1.79763282
27	MP0006276_abnormal_autonomic_nervous	1.79191751
28	MP0005551_abnormal_eye_electrophysiolog	1.78973027
29	MP0006072_abnormal_retinal_apoptosis	1.75508092
30	MP0001486_abnormal_startle_reflex	1.70472221
31	MP0005253_abnormal_eye_physiology	1.57048822
32	MP0003283_abnormal_digestive_organ	1.56122397
33	MP0002938_white_spotting	1.52813731
34	MP0009745_abnormal_behavioral_response	1.46329818
35	MP0002751_abnormal_autonomic_nervous	1.44426686
36	MP0003121_genomic_imprinting	1.43919881
37	MP0002572_abnormal_emotion/affect_behav	1.42690926
38	MP0004924_abnormal_behavior	1.42621849
39	MP0005386_behavior/neurological_phenoty	1.42621849
40	MP0004270_analgesia	1.39339543
41	MP0001970_abnormal_pain_threshold	1.38064011
42	MP0005084_abnormal_gallbladder_morpholo	1.37332076
43	MP0004043_abnormal_pH_regulation	1.35223606
44	MP0000778_abnormal_nervous_system	1.34547048
45	MP0002837_dystrophic_cardiac_calcinosis	1.33189233
46	MP0001905_abnormal_dopamine_level	1.31510494
47	MP0005367_renal/urinary_system_phenotyp	1.30317098
48	MP0000516_abnormal_urinary_system	1.30317098
49	MP0005187_abnormal_penis_morphology	1.28066213
50	MP0010386_abnormal_urinary_bladder	1.27616087
51	MP0002272_abnormal_nervous_system	1.26847791
52	MP0002733_abnormal_thermal_nociception	1.25710015
53	MP0003635_abnormal_synaptic_transmissio	1.23645768
54	MP0002090_abnormal_vision	1.22861977
55	MP0000613_abnormal_salivary_gland	1.20796431
56	MP0004133_heterotaxia	1.20749682
57	MP0002163_abnormal_gland_morphology	1.20635748
58	MP0002653_abnormal_ependyma_morphology	1.18460509
59	MP0002064_seizures	1.13059526
60	MP0003806_abnormal_nucleotide_metabolis	1.11742910
61	MP0004085_abnormal_heartbeat	1.11354847
62	MP0001188_hyperpigmentation	1.10534220
63	MP0005220_abnormal_exocrine_pancreas	1.09924235
64	MP0005379_endocrine/exocrine_gland_phen	1.06935572
65	MP0002254_reproductive_system_inflammat	1.06828338
66	MP0000427_abnormal_hair_cycle	1.04854757
67	MP0002067_abnormal_sensory_capabilities	1.02995044
68	MP0003137_abnormal_impulse_conducting	1.00947389
69	MP0006054_spinal_hemorrhage	0.99718274
70	MP0001293_anophthalmia	0.99537708
71	MP0002233_abnormal_nose_morphology	0.98970761
72	MP0002557_abnormal_social/conspecific_i	0.97838083
73	MP0000631_abnormal_neuroendocrine_gland	0.96304538
74	MP0003119_abnormal_digestive_system	0.95341921
75	MP0009697_abnormal_copulation	0.95299393
76	MP0000538_abnormal_urinary_bladder	0.94358382
77	MP0005195_abnormal_posterior_eye	0.93023659
78	MP0004142_abnormal_muscle_tone	0.91278190
79	MP0003011_delayed_dark_adaptation	0.90963496
80	MP0002909_abnormal_adrenal_gland	0.90705319
81	MP0010094_abnormal_chromosome_stability	0.90458525
82	MP0002063_abnormal_learning/memory/cond	0.90087926
83	MP0005646_abnormal_pituitary_gland	0.88564535
84	MP0001501_abnormal_sleep_pattern	0.87098841
85	MP0003693_abnormal_embryo_hatching	0.86566378
86	MP0004811_abnormal_neuron_physiology	0.85493015
87	MP0002752_abnormal_somatic_nervous	0.84822938
88	MP0003890_abnormal_embryonic-extraembry	0.84074140
89	MP0008872_abnormal_physiological_respon	0.82669542
90	MP0001986_abnormal_taste_sensitivity	0.80467176
91	MP0004215_abnormal_myocardial_fiber	0.80405385
92	MP0003567_abnormal_fetal_cardiomyocyte	0.78472846
93	MP0003183_abnormal_peptide_metabolism	0.77304591
94	MP0005248_abnormal_Harderian_gland	0.76853323
95	MP0003186_abnormal_redox_activity	0.75779238
96	MP0002184_abnormal_innervation	0.75003736
97	MP0003937_abnormal_limbs/digits/tail_de	0.74528477
98	MP0002069_abnormal_eating/drinking_beha	0.74245744
99	MP0005410_abnormal_fertilization	0.73133087
100	MP0002882_abnormal_neuron_morphology	0.72796282

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Intestinal atresia (HP:0011100)	3.70837663
2	Pancreatic cysts (HP:0001737)	3.49495479
3	Hypothermia (HP:0002045)	3.41291428
4	Oligodactyly (hands) (HP:0001180)	3.36527476
5	True hermaphroditism (HP:0010459)	3.28047058
6	Methylmalonic acidemia (HP:0002912)	3.24968677
7	Pancreatic fibrosis (HP:0100732)	3.24322158
8	Molar tooth sign on MRI (HP:0002419)	3.10917501
9	Abnormality of midbrain morphology (HP:0002418)	3.10917501
10	Hyperglycinemia (HP:0002154)	3.09134247
11	Gait imbalance (HP:0002141)	3.01598942
12	Methylmalonic aciduria (HP:0012120)	2.97301993
13	Thyroid-stimulating hormone excess (HP:0002925)	2.93997527
14	Medial flaring of the eyebrow (HP:0010747)	2.90863954
15	Congenital primary aphakia (HP:0007707)	2.83937571
16	Labial hypoplasia (HP:0000066)	2.80830402
17	Aqueductal stenosis (HP:0002410)	2.78952119
18	Abnormality of the labia minora (HP:0012880)	2.78115141
19	Neoplasm of the adrenal cortex (HP:0100641)	2.76946250
20	Nephrogenic diabetes insipidus (HP:0009806)	2.75195112
21	Acute necrotizing encephalopathy (HP:0006965)	2.66036066
22	Genital tract atresia (HP:0001827)	2.65322420
23	Progressive macrocephaly (HP:0004481)	2.65050504
24	Colon cancer (HP:0003003)	2.62508628
25	Hypoplastic female external genitalia (HP:0012815)	2.59750362
26	Polyphagia (HP:0002591)	2.59279879
27	Bifid tongue (HP:0010297)	2.55055679
28	Vaginal atresia (HP:0000148)	2.52497603
29	Esophageal atresia (HP:0002032)	2.50190680
30	Nephronophthisis (HP:0000090)	2.47452333
31	Oligodactyly (HP:0012165)	2.42183365
32	Renal cortical cysts (HP:0000803)	2.42113835
33	Mitochondrial inheritance (HP:0001427)	2.41578574
34	Gastrointestinal atresia (HP:0002589)	2.40717363
35	Congenital stationary night blindness (HP:0007642)	2.26387765
36	Hepatocellular necrosis (HP:0001404)	2.26370034
37	Delayed CNS myelination (HP:0002188)	2.26299546
38	Anophthalmia (HP:0000528)	2.25874696
39	Abnormal mitochondria in muscle tissue (HP:0008316)	2.24780020
40	Narrow forehead (HP:0000341)	2.24775262
41	Anencephaly (HP:0002323)	2.24517614
42	Increased CSF lactate (HP:0002490)	2.24104828
43	Chronic hepatic failure (HP:0100626)	2.23537377
44	Failure to thrive in infancy (HP:0001531)	2.21436857
45	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.21342553
46	Congenital malformation of the right heart (HP:0011723)	2.20746999
47	Double outlet right ventricle (HP:0001719)	2.20746999
48	Abnormality of the labia (HP:0000058)	2.19982774
49	Inability to walk (HP:0002540)	2.19687169
50	Acute encephalopathy (HP:0006846)	2.16227520
51	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.12762518
52	Abnormal biliary tract physiology (HP:0012439)	2.12306536
53	Bile duct proliferation (HP:0001408)	2.12306536
54	Preaxial hand polydactyly (HP:0001177)	2.10476202
55	Abnormality of vitamin B metabolism (HP:0004340)	2.09764813
56	Abnormality of the renal cortex (HP:0011035)	2.08244283
57	Febrile seizures (HP:0002373)	2.08044002
58	Optic nerve hypoplasia (HP:0000609)	2.07743001
59	Gaze-evoked nystagmus (HP:0000640)	2.06979708
60	Broad-based gait (HP:0002136)	2.06153644
61	Hyperventilation (HP:0002883)	2.06073175
62	Type II lissencephaly (HP:0007260)	2.04690825
63	Abnormality of glycine metabolism (HP:0010895)	2.03117630
64	Abnormality of serine family amino acid metabolism (HP:0010894)	2.03117630
65	Large for gestational age (HP:0001520)	2.02497357
66	Lissencephaly (HP:0001339)	2.02368077
67	Amblyopia (HP:0000646)	1.99413492
68	Abnormality of the renal medulla (HP:0100957)	1.98070772
69	Abnormality of the parathyroid morphology (HP:0011766)	1.97828724
70	Focal seizures (HP:0007359)	1.97508161
71	Anosmia (HP:0000458)	1.96738632
72	Cystic liver disease (HP:0006706)	1.94703647
73	Occipital encephalocele (HP:0002085)	1.93729726
74	Hyperglycinuria (HP:0003108)	1.91163843
75	Growth hormone deficiency (HP:0000824)	1.86990785
76	Abnormality of alanine metabolism (HP:0010916)	1.86763166
77	Hyperalaninemia (HP:0003348)	1.86763166
78	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.86763166
79	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.86137341
80	Hepatic necrosis (HP:0002605)	1.84286043
81	Abnormality of macular pigmentation (HP:0008002)	1.84030254
82	Abnormality of serum amino acid levels (HP:0003112)	1.83886424
83	3-Methylglutaconic aciduria (HP:0003535)	1.83069610
84	Volvulus (HP:0002580)	1.82833834
85	Renal hypoplasia (HP:0000089)	1.82774775
86	Neoplasm of the adrenal gland (HP:0100631)	1.82472899
87	Chorioretinal coloboma (HP:0000567)	1.81072781
88	Abnormality of methionine metabolism (HP:0010901)	1.78955357
89	Drooling (HP:0002307)	1.77368890
90	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.76817782
91	Absent eyebrow (HP:0002223)	1.76419192
92	Breast carcinoma (HP:0003002)	1.75883644
93	Retinal dysplasia (HP:0007973)	1.75816432
94	Poor coordination (HP:0002370)	1.75493224
95	Ketoacidosis (HP:0001993)	1.74499017
96	Glioma (HP:0009733)	1.73650662
97	Cerebral edema (HP:0002181)	1.72572815
98	Progressive cerebellar ataxia (HP:0002073)	1.72317979
99	Clitoromegaly (HP:0000057)	1.71923763
100	Atonic seizures (HP:0010819)	1.71694566

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.74438389
2	ZAK	2.86857107
3	TRIM28	2.81545136
4	BMPR1B	2.80822935
5	CASK	2.80139617
6	TNIK	2.73252163
7	MARK1	2.53932190
8	NME1	2.41703211
9	NUAK1	2.26183770
10	ERBB3	2.23619922
11	DYRK3	2.04530074
12	MAP4K2	1.97168146
13	FGFR2	1.84239218
14	CSNK1G1	1.82916483
15	WNK3	1.82459466
16	MAPK13	1.79704194
17	CDC7	1.77906543
18	GRK1	1.74623195
19	MKNK2	1.60543979
20	CAMKK2	1.44554775
21	DYRK2	1.44390167
22	BRSK2	1.42323813
23	PLK3	1.37498339
24	ACVR1B	1.36340941
25	AKT3	1.35878218
26	BCR	1.35163702
27	CDK19	1.33257456
28	EIF2AK3	1.31906511
29	CSNK1G3	1.30095427
30	PNCK	1.27737771
31	CSNK1G2	1.25487789
32	MAP3K4	1.25120016
33	PAK3	1.24633401
34	DYRK1A	1.24416405
35	PLK2	1.23682916
36	MKNK1	1.22821511
37	PINK1	1.20648298
38	CSNK1A1L	1.20478192
39	MINK1	1.19300023
40	INSRR	1.18362711
41	PRKCE	1.15693831
42	MST4	1.15405855
43	FER	1.13305191
44	BCKDK	1.12007861
45	ADRBK2	1.02406278
46	TSSK6	1.01334697
47	MAPKAPK3	0.97921075
48	MAP3K11	0.95498928
49	TGFBR1	0.83831269
50	PLK4	0.82081059
51	NTRK3	0.80727814
52	PRKCG	0.77672750
53	PLK1	0.76737283
54	OXSR1	0.71659668
55	NLK	0.71490868
56	NEK1	0.69464060
57	SRPK1	0.67763275
58	MAP2K7	0.64533337
59	VRK1	0.63263912
60	PBK	0.60213938
61	TIE1	0.59029074
62	DYRK1B	0.58479452
63	CAMK2A	0.57658891
64	SGK2	0.57480517
65	ATM	0.56350422
66	CSNK1A1	0.56202818
67	BUB1	0.55205523
68	ADRBK1	0.53160987
69	PHKG2	0.53003302
70	PHKG1	0.53003302
71	PRKG1	0.51528760
72	YES1	0.51276823
73	PDK2	0.50583142
74	STK16	0.50053833
75	TTK	0.49313064
76	PRKG2	0.48806638
77	MAP3K12	0.47927886
78	CHEK2	0.47479906
79	WEE1	0.46102219
80	MAP2K6	0.44900673
81	TYRO3	0.42387917
82	ERBB4	0.42284072
83	OBSCN	0.42046042
84	PKN1	0.41066582
85	FGR	0.41038941
86	CAMK4	0.40818624
87	PTK2B	0.39355027
88	SGK223	0.39172317
89	SGK494	0.39172317
90	LATS1	0.38630045
91	PRKACB	0.37992138
92	PRKCI	0.37806974
93	PRKDC	0.37376423
94	PRKACA	0.36416542
95	ATR	0.36286615
96	NTRK2	0.35038719
97	PRKCZ	0.33519454
98	CAMK2D	0.33281478
99	ABL2	0.32407626
100	GRK7	0.31362748

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.77298125
2	Protein export_Homo sapiens_hsa03060	3.14613289
3	Non-homologous end-joining_Homo sapiens_hsa03450	2.75417228
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.65727220
5	Fanconi anemia pathway_Homo sapiens_hsa03460	2.25484188
6	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.24177840
7	Nicotine addiction_Homo sapiens_hsa05033	2.23434978
8	Butanoate metabolism_Homo sapiens_hsa00650	2.20420243
9	Phototransduction_Homo sapiens_hsa04744	1.99977231
10	Homologous recombination_Homo sapiens_hsa03440	1.93629995
11	Mismatch repair_Homo sapiens_hsa03430	1.91584524
12	Steroid biosynthesis_Homo sapiens_hsa00100	1.91184911
13	Propanoate metabolism_Homo sapiens_hsa00640	1.87508286
14	Oxidative phosphorylation_Homo sapiens_hsa00190	1.77633567
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.74025135
16	One carbon pool by folate_Homo sapiens_hsa00670	1.68062708
17	Selenocompound metabolism_Homo sapiens_hsa00450	1.66801673
18	Basal transcription factors_Homo sapiens_hsa03022	1.63232412
19	Peroxisome_Homo sapiens_hsa04146	1.56977104
20	RNA degradation_Homo sapiens_hsa03018	1.55705876
21	Parkinsons disease_Homo sapiens_hsa05012	1.53891206
22	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.53475340
23	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.52072673
24	Taste transduction_Homo sapiens_hsa04742	1.51805836
25	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.48873972
26	Base excision repair_Homo sapiens_hsa03410	1.47205907
27	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.39220341
28	GABAergic synapse_Homo sapiens_hsa04727	1.36853345
29	Fatty acid elongation_Homo sapiens_hsa00062	1.31431551
30	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.30770790
31	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.29595804
32	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.25866658
33	Ether lipid metabolism_Homo sapiens_hsa00565	1.25768282
34	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.22673767
35	Regulation of autophagy_Homo sapiens_hsa04140	1.18952245
36	Proteasome_Homo sapiens_hsa03050	1.14858659
37	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.13795481
38	Linoleic acid metabolism_Homo sapiens_hsa00591	1.11399073
39	Glutathione metabolism_Homo sapiens_hsa00480	1.09966302
40	Nitrogen metabolism_Homo sapiens_hsa00910	1.07077856
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.03252025
42	Huntingtons disease_Homo sapiens_hsa05016	1.03221800
43	Morphine addiction_Homo sapiens_hsa05032	1.00390697
44	Olfactory transduction_Homo sapiens_hsa04740	0.99273630
45	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.99214646
46	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.98880243
47	RNA polymerase_Homo sapiens_hsa03020	0.98753056
48	DNA replication_Homo sapiens_hsa03030	0.98419391
49	Glutamatergic synapse_Homo sapiens_hsa04724	0.97986071
50	Serotonergic synapse_Homo sapiens_hsa04726	0.95218119
51	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.91551501
52	Circadian entrainment_Homo sapiens_hsa04713	0.90791241
53	RNA transport_Homo sapiens_hsa03013	0.90646887
54	Dopaminergic synapse_Homo sapiens_hsa04728	0.90274276
55	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.88667684
56	beta-Alanine metabolism_Homo sapiens_hsa00410	0.86450034
57	Folate biosynthesis_Homo sapiens_hsa00790	0.86067732
58	Collecting duct acid secretion_Homo sapiens_hsa04966	0.85850335
59	Purine metabolism_Homo sapiens_hsa00230	0.85719832
60	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.85023289
61	Nucleotide excision repair_Homo sapiens_hsa03420	0.84567363
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.84371007
63	Tryptophan metabolism_Homo sapiens_hsa00380	0.83426788
64	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.82752167
65	Alzheimers disease_Homo sapiens_hsa05010	0.82273587
66	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.79866192
67	Pyrimidine metabolism_Homo sapiens_hsa00240	0.79857057
68	Fatty acid metabolism_Homo sapiens_hsa01212	0.79061108
69	ABC transporters_Homo sapiens_hsa02010	0.78475549
70	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.74377140
71	Metabolic pathways_Homo sapiens_hsa01100	0.72369026
72	Chemical carcinogenesis_Homo sapiens_hsa05204	0.71792522
73	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.71743462
74	Insulin secretion_Homo sapiens_hsa04911	0.71187335
75	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.69692644
76	Sphingolipid metabolism_Homo sapiens_hsa00600	0.67508442
77	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.67148900
78	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.66670767
79	Amphetamine addiction_Homo sapiens_hsa05031	0.66573177
80	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.65576059
81	Fatty acid degradation_Homo sapiens_hsa00071	0.61802680
82	Oocyte meiosis_Homo sapiens_hsa04114	0.59885155
83	Carbon metabolism_Homo sapiens_hsa01200	0.59541756
84	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.58632320
85	Spliceosome_Homo sapiens_hsa03040	0.58618849
86	Pyruvate metabolism_Homo sapiens_hsa00620	0.56642233
87	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.54487805
88	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.52867192
89	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.52472241
90	Arginine and proline metabolism_Homo sapiens_hsa00330	0.50909038
91	Cocaine addiction_Homo sapiens_hsa05030	0.49022364
92	Calcium signaling pathway_Homo sapiens_hsa04020	0.48972236
93	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.46930102
94	Sulfur metabolism_Homo sapiens_hsa00920	0.41034243
95	Tight junction_Homo sapiens_hsa04530	0.40460728
96	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.37875821
97	Caffeine metabolism_Homo sapiens_hsa00232	0.36629557
98	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.35546053
99	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.33227350
100	Long-term depression_Homo sapiens_hsa04730	0.31418117

ZNF839P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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