ZNF84

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.55002567
2nucleobase catabolic process (GO:0046113)5.14056169
3presynaptic membrane assembly (GO:0097105)4.97688245
4presynaptic membrane organization (GO:0097090)4.35933195
5central nervous system projection neuron axonogenesis (GO:0021952)4.20202874
6neuron cell-cell adhesion (GO:0007158)3.98080831
7neural tube formation (GO:0001841)3.87318429
8limb bud formation (GO:0060174)3.86368385
9axonal fasciculation (GO:0007413)3.75570097
10tachykinin receptor signaling pathway (GO:0007217)3.73272516
11postsynaptic membrane organization (GO:0001941)3.66488048
12neuron recognition (GO:0008038)3.60134084
13central nervous system neuron axonogenesis (GO:0021955)3.59162217
14positive regulation of action potential (GO:0045760)3.50940490
15vocalization behavior (GO:0071625)3.38746757
16intraciliary transport (GO:0042073)3.26080685
17neurotransmitter-gated ion channel clustering (GO:0072578)3.23472435
18sympathetic nervous system development (GO:0048485)3.22642585
19DNA double-strand break processing (GO:0000729)3.22347778
20somite development (GO:0061053)3.20068502
21behavioral response to nicotine (GO:0035095)3.17080173
22retinal ganglion cell axon guidance (GO:0031290)3.17047354
23olfactory bulb development (GO:0021772)3.15274798
24negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.11187510
25negative regulation of translation, ncRNA-mediated (GO:0040033)3.11187510
26regulation of translation, ncRNA-mediated (GO:0045974)3.11187510
27nonmotile primary cilium assembly (GO:0035058)3.09733565
28establishment of mitochondrion localization (GO:0051654)3.06411511
29gamma-aminobutyric acid transport (GO:0015812)3.06203775
30synapse assembly (GO:0007416)3.05422293
31positive regulation of dendritic spine morphogenesis (GO:0061003)3.00967956
32regulation of action potential (GO:0098900)2.99737610
33dendrite morphogenesis (GO:0048813)2.94652878
34regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.92765790
35transmission of nerve impulse (GO:0019226)2.91373299
36regulation of collateral sprouting (GO:0048670)2.84736850
37calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.84381150
38retinal cone cell development (GO:0046549)2.82581132
39microtubule anchoring (GO:0034453)2.81831266
40epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.80495675
41protein localization to synapse (GO:0035418)2.80339874
42cerebral cortex radially oriented cell migration (GO:0021799)2.79806659
43ionotropic glutamate receptor signaling pathway (GO:0035235)2.74199075
44regulation of development, heterochronic (GO:0040034)2.69744720
45brain morphogenesis (GO:0048854)2.68827136
46negative regulation of DNA recombination (GO:0045910)2.68391065
47spinal cord development (GO:0021510)2.67069917
48head development (GO:0060322)2.66600624
49behavioral response to ethanol (GO:0048149)2.64516212
50histone H2A acetylation (GO:0043968)2.64045491
51DNA integration (GO:0015074)2.63443673
52regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.62902271
53regulation of telomere maintenance (GO:0032204)2.62551716
54glutamate receptor signaling pathway (GO:0007215)2.62455017
55resolution of meiotic recombination intermediates (GO:0000712)2.61898119
56neuronal action potential propagation (GO:0019227)2.61745606
57regulation of feeding behavior (GO:0060259)2.61629441
58regulation of glucocorticoid secretion (GO:2000849)2.60673567
59positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.59973609
60forebrain neuron differentiation (GO:0021879)2.58893460
61regulation of timing of cell differentiation (GO:0048505)2.58682982
62negative regulation of heart rate (GO:0010459)2.58401395
63cell migration in hindbrain (GO:0021535)2.53799860
64glycosphingolipid biosynthetic process (GO:0006688)2.51719992
65kidney morphogenesis (GO:0060993)2.51609383
66DNA damage response, detection of DNA damage (GO:0042769)2.50760033
67positive regulation of synaptic transmission, GABAergic (GO:0032230)2.50470834
68synaptic transmission, glutamatergic (GO:0035249)2.50309580
69hindbrain development (GO:0030902)2.50025593
70regulation of dendritic spine morphogenesis (GO:0061001)2.47996547
71ganglion development (GO:0061548)2.47734757
72retinal rod cell development (GO:0046548)2.47511723
73positive regulation of oligodendrocyte differentiation (GO:0048714)2.46228305
74axonogenesis (GO:0007409)2.46144922
75regulation of cilium movement (GO:0003352)2.45854364
76regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.44310987
77cerebral cortex cell migration (GO:0021795)2.44304277
78acrosome assembly (GO:0001675)2.43685441
79hippocampus development (GO:0021766)2.40379789
80positive regulation of synapse assembly (GO:0051965)2.40329214
81limb development (GO:0060173)2.39822458
82appendage development (GO:0048736)2.39822458
83dendritic spine morphogenesis (GO:0060997)2.39057372
84epithelial cilium movement (GO:0003351)2.38940518
85cilium organization (GO:0044782)2.38667112
86protein localization to cilium (GO:0061512)2.37665881
87cilium assembly (GO:0042384)2.37566987
88cilium morphogenesis (GO:0060271)2.35679886
89microtubule depolymerization (GO:0007019)2.35027735
90neuronal stem cell maintenance (GO:0097150)2.33582028
91photoreceptor cell development (GO:0042461)2.31466516
92response to pheromone (GO:0019236)2.31210287
93negative regulation of dendrite development (GO:2000171)2.31138401
94G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.30643161
95regulation of mRNA splicing, via spliceosome (GO:0048024)2.29550950
96startle response (GO:0001964)2.27676655
97atrial cardiac muscle cell action potential (GO:0086014)2.26283008
98heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.25863638
99auditory behavior (GO:0031223)2.25600922
100homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.25441732

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.48251894
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.40322128
3GBX2_23144817_ChIP-Seq_PC3_Human3.34130869
4ZNF274_21170338_ChIP-Seq_K562_Hela3.18334707
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.08528347
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.95778803
7IGF1R_20145208_ChIP-Seq_DFB_Human2.87800890
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.84466212
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.80280146
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.78742325
11FUS_26573619_Chip-Seq_HEK293_Human2.71436217
12TAF15_26573619_Chip-Seq_HEK293_Human2.59877852
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.52437997
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.39750170
15EWS_26573619_Chip-Seq_HEK293_Human2.26537879
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.23240015
17VDR_22108803_ChIP-Seq_LS180_Human2.12104153
18P300_19829295_ChIP-Seq_ESCs_Human2.11214711
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.08986108
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08623274
21PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.00354410
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97954439
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.89388640
24SMAD4_21799915_ChIP-Seq_A2780_Human1.79707466
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77644120
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.74362256
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.74165369
28SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.73870177
29MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.71282203
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70217229
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.69343479
32RNF2_27304074_Chip-Seq_NSC_Mouse1.68588107
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.67092529
34OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66800116
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.59334133
36POU5F1_16153702_ChIP-ChIP_HESCs_Human1.57954322
37SMAD3_21741376_ChIP-Seq_EPCs_Human1.54707975
38TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52561159
39STAT3_23295773_ChIP-Seq_U87_Human1.51606890
40SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49673568
41REST_21632747_ChIP-Seq_MESCs_Mouse1.47814585
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46726015
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46511082
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45861526
45TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41926279
46POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41926279
47CBP_20019798_ChIP-Seq_JUKART_Human1.40268350
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40268350
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39715235
50AR_25329375_ChIP-Seq_VCAP_Human1.36304794
51TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35382604
52ER_23166858_ChIP-Seq_MCF-7_Human1.35103280
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32049520
54RUNX2_22187159_ChIP-Seq_PCA_Human1.31888624
55TCF4_23295773_ChIP-Seq_U87_Human1.31434003
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30398472
57EZH2_27304074_Chip-Seq_ESCs_Mouse1.28068496
58BCAT_22108803_ChIP-Seq_LS180_Human1.27962296
59NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26820628
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.26663435
61KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25060472
62TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22225313
63SOX9_26525672_Chip-Seq_HEART_Mouse1.20539730
64AR_21572438_ChIP-Seq_LNCaP_Human1.18820183
65EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17684758
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.17608948
67KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.17274943
68KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.14702259
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14666993
70ELK1_19687146_ChIP-ChIP_HELA_Human1.13895917
71TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13444825
72HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.13089653
73FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13025683
74TAL1_26923725_Chip-Seq_HPCs_Mouse1.12327691
75SOX2_21211035_ChIP-Seq_LN229_Gbm1.11278792
76SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.10879617
77TCF4_22108803_ChIP-Seq_LS180_Human1.10565232
78REST_18959480_ChIP-ChIP_MESCs_Mouse1.10496305
79JARID2_20064375_ChIP-Seq_MESCs_Mouse1.09877855
80EZH2_27294783_Chip-Seq_NPCs_Mouse1.09274836
81CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08848048
82BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08149739
83SOX2_16153702_ChIP-ChIP_HESCs_Human1.07177241
84STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06017451
85P53_22387025_ChIP-Seq_ESCs_Mouse1.05519485
86PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04139343
87GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03722395
88LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01018742
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00954549
90FLI1_21867929_ChIP-Seq_TH2_Mouse1.00494555
91E2F1_18555785_Chip-Seq_ESCs_Mouse0.99872314
92NFE2_27457419_Chip-Seq_LIVER_Mouse0.99564545
93RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98879708
94PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98304992
95RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98150324
96E2F4_17652178_ChIP-ChIP_JURKAT_Human0.96661067
97CMYC_18555785_Chip-Seq_ESCs_Mouse0.96292883
98TP53_22573176_ChIP-Seq_HFKS_Human0.95647338
99CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95422783
100CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95321539

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.39287707
2MP0000778_abnormal_nervous_system2.71515448
3MP0003787_abnormal_imprinting2.62139128
4MP0004859_abnormal_synaptic_plasticity2.56829006
5MP0004270_analgesia2.33121863
6MP0008877_abnormal_DNA_methylation2.32892608
7MP0008789_abnormal_olfactory_epithelium2.14645362
8MP0001529_abnormal_vocalization2.12529607
9MP0001486_abnormal_startle_reflex2.10297190
10MP0003122_maternal_imprinting2.09859766
11MP0010386_abnormal_urinary_bladder2.09362869
12MP0002822_catalepsy2.07426445
13MP0006276_abnormal_autonomic_nervous2.07040378
14MP0005499_abnormal_olfactory_system2.05091417
15MP0005394_taste/olfaction_phenotype2.05091417
16MP0003121_genomic_imprinting2.03792051
17MP0002102_abnormal_ear_morphology1.99766374
18MP0001984_abnormal_olfaction1.99285848
19MP0003635_abnormal_synaptic_transmissio1.89470920
20MP0006292_abnormal_olfactory_placode1.89168263
21MP0006072_abnormal_retinal_apoptosis1.80583124
22MP0002751_abnormal_autonomic_nervous1.73260476
23MP0004885_abnormal_endolymph1.73037681
24MP0001188_hyperpigmentation1.68873157
25MP0002735_abnormal_chemical_nociception1.67623410
26MP0002184_abnormal_innervation1.66179463
27MP0002638_abnormal_pupillary_reflex1.63810025
28MP0000566_synostosis1.63599012
29MP0002272_abnormal_nervous_system1.61961882
30MP0002063_abnormal_learning/memory/cond1.61108686
31MP0001968_abnormal_touch/_nociception1.60906915
32MP0009745_abnormal_behavioral_response1.59310272
33MP0002736_abnormal_nociception_after1.57653898
34MP0005248_abnormal_Harderian_gland1.55385650
35MP0002734_abnormal_mechanical_nocicepti1.54147638
36MP0004133_heterotaxia1.53482857
37MP0003890_abnormal_embryonic-extraembry1.50050911
38MP0000516_abnormal_urinary_system1.48544742
39MP0005367_renal/urinary_system_phenotyp1.48544742
40MP0000631_abnormal_neuroendocrine_gland1.48253910
41MP0002572_abnormal_emotion/affect_behav1.47530541
42MP0005423_abnormal_somatic_nervous1.46820988
43MP0005187_abnormal_penis_morphology1.44004851
44MP0005253_abnormal_eye_physiology1.43114617
45MP0001177_atelectasis1.40872863
46MP0000955_abnormal_spinal_cord1.40133329
47MP0005551_abnormal_eye_electrophysiolog1.37252347
48MP0002064_seizures1.36676155
49MP0002234_abnormal_pharynx_morphology1.34629955
50MP0000049_abnormal_middle_ear1.33056246
51MP0004924_abnormal_behavior1.31814173
52MP0005386_behavior/neurological_phenoty1.31814173
53MP0009046_muscle_twitch1.31320648
54MP0002233_abnormal_nose_morphology1.28676892
55MP0003119_abnormal_digestive_system1.27933853
56MP0004142_abnormal_muscle_tone1.27615953
57MP0002557_abnormal_social/conspecific_i1.27574694
58MP0003937_abnormal_limbs/digits/tail_de1.27492115
59MP0002882_abnormal_neuron_morphology1.26119523
60MP0001293_anophthalmia1.25096415
61MP0004811_abnormal_neuron_physiology1.23383849
62MP0008058_abnormal_DNA_repair1.23237839
63MP0003861_abnormal_nervous_system1.22914913
64MP0002653_abnormal_ependyma_morphology1.22477583
65MP0002067_abnormal_sensory_capabilities1.18508434
66MP0002752_abnormal_somatic_nervous1.16806747
67MP0002152_abnormal_brain_morphology1.14946476
68MP0000569_abnormal_digit_pigmentation1.14697215
69MP0003755_abnormal_palate_morphology1.09089818
70MP0003385_abnormal_body_wall1.06601778
71MP0001970_abnormal_pain_threshold1.05196725
72MP0005645_abnormal_hypothalamus_physiol1.04718182
73MP0005646_abnormal_pituitary_gland1.04688759
74MP0000647_abnormal_sebaceous_gland1.01963712
75MP0001485_abnormal_pinna_reflex1.00276024
76MP0000427_abnormal_hair_cycle0.98212836
77MP0002938_white_spotting0.97024709
78MP0001286_abnormal_eye_development0.95398993
79MP0001299_abnormal_eye_distance/0.94097687
80MP0005195_abnormal_posterior_eye0.93439549
81MP0004742_abnormal_vestibular_system0.91557644
82MP0005391_vision/eye_phenotype0.91253960
83MP0004147_increased_porphyrin_level0.90721611
84MP0003938_abnormal_ear_development0.90473946
85MP0000026_abnormal_inner_ear0.90074178
86MP0003567_abnormal_fetal_cardiomyocyte0.88796489
87MP0003136_yellow_coat_color0.87719655
88MP0002066_abnormal_motor_capabilities/c0.84194419
89MP0003698_abnormal_male_reproductive0.81387346
90MP0000534_abnormal_ureter_morphology0.80233677
91MP0008995_early_reproductive_senescence0.79664544
92MP0003935_abnormal_craniofacial_develop0.78162928
93MP0001346_abnormal_lacrimal_gland0.77018183
94MP0002733_abnormal_thermal_nociception0.76751486
95MP0002081_perinatal_lethality0.75774896
96MP0010030_abnormal_orbit_morphology0.75652028
97MP0002069_abnormal_eating/drinking_beha0.75236798
98MP0001963_abnormal_hearing_physiology0.73685981
99MP0000537_abnormal_urethra_morphology0.72454855
100MP0003718_maternal_effect0.72426125

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)3.46646844
2Hepatoblastoma (HP:0002884)3.26391723
3Gait imbalance (HP:0002141)3.22959812
4Hyperventilation (HP:0002883)3.11579579
5Focal motor seizures (HP:0011153)3.08059801
6Medial flaring of the eyebrow (HP:0010747)3.06386182
7Colon cancer (HP:0003003)3.04960826
8Congenital primary aphakia (HP:0007707)2.99739790
9Drooling (HP:0002307)2.96575986
10Volvulus (HP:0002580)2.92686278
11Genital tract atresia (HP:0001827)2.91426210
12Nephrogenic diabetes insipidus (HP:0009806)2.84337169
13Pancreatic fibrosis (HP:0100732)2.79957586
14Nephronophthisis (HP:0000090)2.78040069
15Vaginal atresia (HP:0000148)2.77189523
16Focal seizures (HP:0007359)2.77076833
17Abnormality of midbrain morphology (HP:0002418)2.75948213
18Molar tooth sign on MRI (HP:0002419)2.75948213
19Intestinal atresia (HP:0011100)2.68822540
20Pancreatic cysts (HP:0001737)2.66657118
21Excessive salivation (HP:0003781)2.66099850
22Broad-based gait (HP:0002136)2.59269894
23Lissencephaly (HP:0001339)2.58640829
24True hermaphroditism (HP:0010459)2.55134085
25Chronic hepatic failure (HP:0100626)2.54653395
26Abnormality of the renal medulla (HP:0100957)2.53967772
27Tubulointerstitial nephritis (HP:0001970)2.45228010
28Febrile seizures (HP:0002373)2.43699580
29Absent speech (HP:0001344)2.39213047
30Papillary thyroid carcinoma (HP:0002895)2.39069617
31Postaxial hand polydactyly (HP:0001162)2.34714689
32Renal hypoplasia (HP:0000089)2.31184623
33Retinal dysplasia (HP:0007973)2.30541753
34Hip dysplasia (HP:0001385)2.28396067
35Poor coordination (HP:0002370)2.26829455
36Aplasia/Hypoplasia of the tibia (HP:0005772)2.24612319
37Megalencephaly (HP:0001355)2.21428833
38Pachygyria (HP:0001302)2.19152663
39Hypsarrhythmia (HP:0002521)2.12830318
40Cortical dysplasia (HP:0002539)2.10611616
41Short tibia (HP:0005736)2.09671906
42Optic nerve hypoplasia (HP:0000609)2.05583707
43Specific learning disability (HP:0001328)2.04782587
44Atonic seizures (HP:0010819)2.03221816
45Degeneration of the lateral corticospinal tracts (HP:0002314)2.02650195
46Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.02650195
47EEG with generalized epileptiform discharges (HP:0011198)2.02298622
48Renal cortical cysts (HP:0000803)2.01598477
49Genetic anticipation (HP:0003743)2.01346775
50Protruding tongue (HP:0010808)2.01174120
51Epileptic encephalopathy (HP:0200134)2.00670056
52Astrocytoma (HP:0009592)2.00514626
53Abnormality of the astrocytes (HP:0100707)2.00514626
54Narrow forehead (HP:0000341)1.99771641
55Epileptiform EEG discharges (HP:0011182)1.97897255
56Amyotrophic lateral sclerosis (HP:0007354)1.97848096
57Abnormality of the renal cortex (HP:0011035)1.96657080
58Progressive cerebellar ataxia (HP:0002073)1.95863119
59Decreased testicular size (HP:0008734)1.95412358
60Type II lissencephaly (HP:0007260)1.94566337
61Gaze-evoked nystagmus (HP:0000640)1.93024575
62Abnormality of the corticospinal tract (HP:0002492)1.92440083
63Medulloblastoma (HP:0002885)1.92289960
64Postaxial foot polydactyly (HP:0001830)1.92277505
65Broad foot (HP:0001769)1.91012370
66Methylmalonic acidemia (HP:0002912)1.88588519
67Micropenis (HP:0000054)1.87478161
68Aplasia/Hypoplasia of the tongue (HP:0010295)1.85747197
69Cutaneous finger syndactyly (HP:0010554)1.85218197
70Preaxial hand polydactyly (HP:0001177)1.84299001
71Gastrointestinal atresia (HP:0002589)1.83754621
72Polyphagia (HP:0002591)1.83600651
73Aplasia/Hypoplasia of the sternum (HP:0006714)1.83199821
74Exotropia (HP:0000577)1.83087353
75Neoplasm of the adrenal cortex (HP:0100641)1.83085429
76Limb dystonia (HP:0002451)1.81189456
77Short foot (HP:0001773)1.80556272
78Aqueductal stenosis (HP:0002410)1.80391020
79Oligodactyly (hands) (HP:0001180)1.80223728
80Supernumerary spleens (HP:0009799)1.79180180
81Vitreoretinal degeneration (HP:0000655)1.78640133
82Cupped ear (HP:0000378)1.77173860
83Neoplasm of the oral cavity (HP:0100649)1.76865602
84Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76597977
85Glioma (HP:0009733)1.76148045
86Tented upper lip vermilion (HP:0010804)1.70768543
87Hyperglycinemia (HP:0002154)1.70491451
88Thyroid carcinoma (HP:0002890)1.69974208
89Anophthalmia (HP:0000528)1.69482823
90Dandy-Walker malformation (HP:0001305)1.68367320
91Urinary urgency (HP:0000012)1.67501807
92Dialeptic seizures (HP:0011146)1.66309944
93Cystic liver disease (HP:0006706)1.66155249
94Short 4th metacarpal (HP:0010044)1.61490745
95Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.61490745
96Astigmatism (HP:0000483)1.60830643
97Absent eyebrow (HP:0002223)1.59539056
98Impaired vibration sensation in the lower limbs (HP:0002166)1.58664936
99Prominent nasal bridge (HP:0000426)1.58599209
100Rib fusion (HP:0000902)1.58379377

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.53016455
2CASK3.73670097
3MAP3K43.21631251
4WNK32.86686815
5BCR2.68984481
6FRK2.66838615
7EPHA42.61619179
8MAPK132.32183399
9MAP2K72.32030335
10MAP4K22.17542863
11SRPK11.97752752
12TRIM281.88153317
13DYRK21.72906867
14NTRK21.71689948
15NTRK31.71498302
16ERBB31.70405813
17TNIK1.64874170
18FGFR21.59486323
19MKNK21.55659354
20AKT31.55495865
21CSNK1G21.51029652
22PINK11.44026469
23BMPR1B1.44005183
24CSNK1G11.41441710
25CSNK1A1L1.37045009
26MKNK11.34456948
27CSNK1G31.30294227
28BRD41.28738861
29UHMK11.19499562
30NUAK11.18471960
31DYRK31.17434886
32INSRR1.17057644
33SGK21.16906884
34ZAK1.16449660
35PAK31.12085602
36MAP2K41.08469979
37PLK41.05699986
38GRK11.04729669
39ADRBK20.96830358
40PNCK0.96400002
41SGK2230.94129108
42SGK4940.94129108
43RPS6KA40.93331696
44STK38L0.89862897
45MINK10.88109915
46SIK20.87523586
47EPHA30.84155303
48DYRK1A0.83198814
49EPHB20.82577869
50PRKCE0.81983978
51KSR10.81320290
52PLK20.79174971
53CDC70.78675980
54STK390.76984205
55PRKCG0.74266425
56TYRO30.72693101
57CDK50.71918189
58ACVR1B0.71910119
59CDK30.71708684
60PKN10.71300208
61PLK30.68127956
62CCNB10.66593135
63BCKDK0.65703686
64BUB10.63127603
65CDK190.62505048
66OXSR10.57492614
67CSNK1D0.55077262
68SGK30.54517983
69CAMK40.54415603
70PLK10.54408852
71PRKCZ0.54218947
72ATM0.53703648
73VRK10.52320318
74TTK0.50915254
75CAMK2A0.50406412
76MAP3K60.50322046
77WEE10.49782626
78ATR0.49437112
79LATS10.48731368
80FGFR10.48644076
81PAK60.48029461
82DAPK20.47091527
83CDK80.46215980
84WNK40.45878185
85ERBB20.44047614
86CSNK1E0.43553004
87CAMK1G0.41866618
88CHEK20.39352299
89EIF2AK30.39293235
90CSNK1A10.38919260
91CDK180.38318538
92PRKACB0.38285093
93CAMK2B0.36283929
94TSSK60.35619982
95CDK140.34946399
96PRKDC0.34770851
97OBSCN0.33955501
98YES10.33698455
99DYRK1B0.33642165
100CDK150.33626615

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.50504484
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.25321284
3Fanconi anemia pathway_Homo sapiens_hsa034602.28520398
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.15397694
5Basal transcription factors_Homo sapiens_hsa030222.14855486
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.99742607
7Taste transduction_Homo sapiens_hsa047421.89489744
8Butanoate metabolism_Homo sapiens_hsa006501.88195874
9Glutamatergic synapse_Homo sapiens_hsa047241.87904343
10Phototransduction_Homo sapiens_hsa047441.85622193
11Protein export_Homo sapiens_hsa030601.83323604
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83237112
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.79075529
14GABAergic synapse_Homo sapiens_hsa047271.78055482
15Propanoate metabolism_Homo sapiens_hsa006401.69787244
16Non-homologous end-joining_Homo sapiens_hsa034501.67540556
17Steroid biosynthesis_Homo sapiens_hsa001001.65717504
18Circadian entrainment_Homo sapiens_hsa047131.65430070
19Cocaine addiction_Homo sapiens_hsa050301.62943802
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.59424716
21Dopaminergic synapse_Homo sapiens_hsa047281.59357796
22Axon guidance_Homo sapiens_hsa043601.58345400
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.55620315
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49155894
25RNA degradation_Homo sapiens_hsa030181.46258391
26Synaptic vesicle cycle_Homo sapiens_hsa047211.44398780
27Amphetamine addiction_Homo sapiens_hsa050311.43544831
28Morphine addiction_Homo sapiens_hsa050321.42491516
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36087303
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27388983
31mRNA surveillance pathway_Homo sapiens_hsa030151.24740040
32RNA transport_Homo sapiens_hsa030131.23111621
33Homologous recombination_Homo sapiens_hsa034401.20281791
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18389197
35Spliceosome_Homo sapiens_hsa030401.14517385
36Insulin secretion_Homo sapiens_hsa049111.12514068
37Hedgehog signaling pathway_Homo sapiens_hsa043401.11604176
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11551898
39Long-term depression_Homo sapiens_hsa047301.10046390
40Regulation of autophagy_Homo sapiens_hsa041401.09604758
41Cholinergic synapse_Homo sapiens_hsa047251.08871542
42Basal cell carcinoma_Homo sapiens_hsa052171.07354925
43Circadian rhythm_Homo sapiens_hsa047101.07008547
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06058046
45Serotonergic synapse_Homo sapiens_hsa047260.98259372
46Oocyte meiosis_Homo sapiens_hsa041140.94853421
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94461129
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.92131668
49Dorso-ventral axis formation_Homo sapiens_hsa043200.91613618
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90540520
51Hippo signaling pathway_Homo sapiens_hsa043900.88465680
52Wnt signaling pathway_Homo sapiens_hsa043100.86388514
53Alcoholism_Homo sapiens_hsa050340.78077400
54RNA polymerase_Homo sapiens_hsa030200.77691576
55cAMP signaling pathway_Homo sapiens_hsa040240.76567189
56Olfactory transduction_Homo sapiens_hsa047400.76018665
57Ether lipid metabolism_Homo sapiens_hsa005650.75796783
58Cell cycle_Homo sapiens_hsa041100.75785887
59Gap junction_Homo sapiens_hsa045400.73974433
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73188929
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73108843
62Base excision repair_Homo sapiens_hsa034100.72292572
63Nucleotide excision repair_Homo sapiens_hsa034200.69900427
64beta-Alanine metabolism_Homo sapiens_hsa004100.69011962
65Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66870257
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.66690891
67Lysine degradation_Homo sapiens_hsa003100.66333696
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66282867
69Nitrogen metabolism_Homo sapiens_hsa009100.66209485
70Salivary secretion_Homo sapiens_hsa049700.65580226
71Mismatch repair_Homo sapiens_hsa034300.65325183
72Renin secretion_Homo sapiens_hsa049240.65194873
73Colorectal cancer_Homo sapiens_hsa052100.64223533
74Linoleic acid metabolism_Homo sapiens_hsa005910.63557855
75Peroxisome_Homo sapiens_hsa041460.59800682
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59271138
77Collecting duct acid secretion_Homo sapiens_hsa049660.58654200
78Huntingtons disease_Homo sapiens_hsa050160.56414882
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54087112
80Tryptophan metabolism_Homo sapiens_hsa003800.50984566
81Calcium signaling pathway_Homo sapiens_hsa040200.49912916
82Oxidative phosphorylation_Homo sapiens_hsa001900.48795660
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48328687
84Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.48127391
85Selenocompound metabolism_Homo sapiens_hsa004500.47454328
86Oxytocin signaling pathway_Homo sapiens_hsa049210.46174555
87TGF-beta signaling pathway_Homo sapiens_hsa043500.45899800
88Long-term potentiation_Homo sapiens_hsa047200.44324703
89Tight junction_Homo sapiens_hsa045300.43957310
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43736843
91Melanoma_Homo sapiens_hsa052180.42438249
92Melanogenesis_Homo sapiens_hsa049160.41046087
93Parkinsons disease_Homo sapiens_hsa050120.40751255
94Type II diabetes mellitus_Homo sapiens_hsa049300.40192547
95Ras signaling pathway_Homo sapiens_hsa040140.36489219
96Retinol metabolism_Homo sapiens_hsa008300.34638029
97Fatty acid metabolism_Homo sapiens_hsa012120.33900846
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33107222
99Purine metabolism_Homo sapiens_hsa002300.32995991
100Thyroid hormone synthesis_Homo sapiens_hsa049180.32967967

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