ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of acrosome reaction (GO:0060046)	9.48777370
2	regulation of meiosis I (GO:0060631)	8.31843014
3	piRNA metabolic process (GO:0034587)	8.31438614
4	meiotic cell cycle (GO:0051321)	8.18366905
5	retinal cone cell development (GO:0046549)	7.66000645
6	multicellular organism reproduction (GO:0032504)	7.27538381
7	DNA methylation involved in gamete generation (GO:0043046)	6.92282693
8	positive regulation of histone H3-K4 methylation (GO:0051571)	6.88674203
9	oocyte development (GO:0048599)	6.82239441
10	regulation of histone H3-K9 methylation (GO:0051570)	6.75085613
11	female gamete generation (GO:0007292)	6.39909124
12	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	6.25906596
13	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	6.25906596
14	positive regulation of mitotic sister chromatid separation (GO:1901970)	6.25906596
15	negative regulation of reproductive process (GO:2000242)	6.16307276
16	regulation of cell maturation (GO:1903429)	6.02159075
17	protein kinase C signaling (GO:0070528)	5.98920154
18	regulation of steroid hormone secretion (GO:2000831)	5.86721188
19	negative regulation of histone methylation (GO:0031061)	5.85774026
20	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	5.62995354
21	protein localization to kinetochore (GO:0034501)	5.58226632
22	positive regulation of humoral immune response (GO:0002922)	5.49005361
23	centriole replication (GO:0007099)	5.47692277
24	protein localization to chromosome, centromeric region (GO:0071459)	5.17575713
25	positive regulation of chromosome segregation (GO:0051984)	5.16610274
26	gene silencing by RNA (GO:0031047)	5.10285152
27	positive regulation of gastrulation (GO:2000543)	5.06638985
28	mitotic chromosome condensation (GO:0007076)	4.99300803
29	mitotic metaphase plate congression (GO:0007080)	4.90251946
30	establishment of chromosome localization (GO:0051303)	4.87577082
31	reproduction (GO:0000003)	4.80421122
32	glycine transport (GO:0015816)	4.79291050
33	primitive streak formation (GO:0090009)	4.53797353
34	positive regulation of histone methylation (GO:0031062)	4.37671012
35	regulation of steroid hormone biosynthetic process (GO:0090030)	4.23310037
36	citrulline biosynthetic process (GO:0019240)	4.23154891
37	regulation of meiosis (GO:0040020)	4.21208230
38	synaptonemal complex assembly (GO:0007130)	4.20460092
39	synapsis (GO:0007129)	4.14202526
40	protein localization to chromosome (GO:0034502)	4.10011714
41	binding of sperm to zona pellucida (GO:0007339)	4.06365776
42	fertilization (GO:0009566)	4.03750577
43	regulation of histone H3-K4 methylation (GO:0051569)	3.98676836
44	metaphase plate congression (GO:0051310)	3.96738947
45	DNA methylation (GO:0006306)	3.93975998
46	DNA alkylation (GO:0006305)	3.93975998
47	attachment of spindle microtubules to kinetochore (GO:0008608)	3.86296765
48	chromosome organization involved in meiosis (GO:0070192)	3.85981114
49	regulation of histone methylation (GO:0031060)	3.79408313
50	male meiosis (GO:0007140)	3.75223869
51	phosphorelay signal transduction system (GO:0000160)	3.74755044
52	positive regulation of reproductive process (GO:2000243)	3.74104153
53	centriole assembly (GO:0098534)	3.73259083
54	relaxation of smooth muscle (GO:0044557)	3.72594789
55	synaptonemal complex organization (GO:0070193)	3.71795381
56	negative regulation of hormone biosynthetic process (GO:0032353)	3.71345607
57	negative regulation of cAMP-mediated signaling (GO:0043951)	3.69856006
58	male meiosis I (GO:0007141)	3.65690587
59	oogenesis (GO:0048477)	3.64745069
60	regulation of spindle organization (GO:0090224)	3.60251461
61	single fertilization (GO:0007338)	3.54355574
62	regulation of reproductive process (GO:2000241)	3.53389995
63	regulation of chromatin silencing (GO:0031935)	3.51599927
64	negative regulation of hormone metabolic process (GO:0032351)	3.49007480
65	neuron fate determination (GO:0048664)	3.46651424
66	regulation of calcium ion-dependent exocytosis (GO:0017158)	3.46021161
67	regulation of meiotic cell cycle (GO:0051445)	3.45308358
68	gene silencing (GO:0016458)	3.45059995
69	negative regulation of histone modification (GO:0031057)	3.44797458
70	CENP-A containing nucleosome assembly (GO:0034080)	3.41982207
71	somite rostral/caudal axis specification (GO:0032525)	3.41062143
72	meiotic nuclear division (GO:0007126)	3.39830743
73	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.37994145
74	nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)	3.36626680
75	labyrinthine layer development (GO:0060711)	3.35094247
76	regulation of spindle checkpoint (GO:0090231)	3.34795514
77	L-amino acid import (GO:0043092)	3.33883600
78	regulation of corticosteroid hormone secretion (GO:2000846)	3.33239113
79	negative regulation of execution phase of apoptosis (GO:1900118)	3.32854343
80	meiotic cell cycle process (GO:1903046)	3.29741063
81	DNA damage induced protein phosphorylation (GO:0006975)	3.26008158
82	genitalia morphogenesis (GO:0035112)	3.17997934
83	regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:0043	3.14489880
84	sperm-egg recognition (GO:0035036)	3.14372529
85	DNA replication-dependent nucleosome organization (GO:0034723)	3.12752848
86	DNA replication-dependent nucleosome assembly (GO:0006335)	3.12752848
87	interkinetic nuclear migration (GO:0022027)	3.12656042
88	regulation of phospholipid biosynthetic process (GO:0071071)	3.11645731
89	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	3.11201858
90	regulation of G2/M transition of mitotic cell cycle (GO:0010389)	3.10654773
91	translesion synthesis (GO:0019985)	3.09814061
92	regulation of hypersensitivity (GO:0002883)	3.09545314
93	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.09539858
94	regulation of RNA export from nucleus (GO:0046831)	3.09035013
95	chromatin remodeling at centromere (GO:0031055)	3.07941006
96	negative regulation of chromatin modification (GO:1903309)	3.06227419
97	centrosome duplication (GO:0051298)	3.06205265
98	N-terminal protein amino acid acetylation (GO:0006474)	3.05985269
99	regulation of DNA methylation (GO:0044030)	10.7117617
100	regulation of female gonad development (GO:2000194)	10.4531149

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.95714617
2	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	5.29626746
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.17696992
4	E2F7_22180533_ChIP-Seq_HELA_Human	3.26078678
5	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	2.77102825
6	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	2.77102825
7	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	2.77102825
8	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.74299813
9	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.72361352
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.71384898
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.58427963
12	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.54867805
13	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.05764969
14	EZH2_22144423_ChIP-Seq_EOC_Human	14.8036748
15	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.93381263
16	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.90648241
17	GBX2_23144817_ChIP-Seq_PC3_Human	1.90378671
18	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.88428968
19	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.74573737
20	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.65321813
21	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.63180339
22	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.60755553
23	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.52706100
24	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.50103272
25	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.45975327
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.43050259
27	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.36425817
28	AR_21909140_ChIP-Seq_LNCAP_Human	1.33711158
29	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.25802075
30	CBP_20019798_ChIP-Seq_JUKART_Human	1.25126680
31	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.25126680
32	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.24327684
33	TCF4_23295773_ChIP-Seq_U87_Human	1.21693211
34	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.20886263
35	IRF1_19129219_ChIP-ChIP_H3396_Human	1.19963928
36	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.16820928
37	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.10718966
38	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.07992619
39	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.07016928
40	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.07016928
41	AR_25329375_ChIP-Seq_VCAP_Human	1.06395482
42	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.05528604
43	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.03198141
44	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.02637940
45	SMAD4_21799915_ChIP-Seq_A2780_Human	1.02347605
46	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01736586
47	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01211632
48	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.99791500
49	STAT3_23295773_ChIP-Seq_U87_Human	0.96969530
50	RUNX2_22187159_ChIP-Seq_PCA_Human	0.96651707
51	EWS_26573619_Chip-Seq_HEK293_Human	0.96145026
52	GF1_26923725_Chip-Seq_HPCs_Mouse	0.94246376
53	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.93779480
54	HTT_18923047_ChIP-ChIP_STHdh_Human	0.93762629
55	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.92111461
56	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.91760779
57	CBP_21632823_ChIP-Seq_H3396_Human	0.90757499
58	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.88355073
59	NANOG_20526341_ChIP-Seq_ESCs_Human	0.87693340
60	P300_19829295_ChIP-Seq_ESCs_Human	0.87424851
61	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.86915707
62	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.84782679
63	AHR_22903824_ChIP-Seq_MCF-7_Human	0.83596486
64	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.83311062
65	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.82564099
66	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.81894311
67	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.81602565
68	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.81478152
69	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.80962971
70	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.80957095
71	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.80071535
72	TP53_16413492_ChIP-PET_HCT116_Human	0.79481965
73	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.78815022
74	GATA1_19941827_ChIP-Seq_MEL86_Mouse	0.77012181
75	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.76542024
76	SMRT_27268052_Chip-Seq_Bcells_Human	0.73908338
77	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.73305186
78	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.72820285
79	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.68829885
80	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.68548202
81	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.66842370
82	TP53_22573176_ChIP-Seq_HFKS_Human	0.66351343
83	KLF4_19829295_ChIP-Seq_ESCs_Human	0.65782283
84	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.64506745
85	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.64310537
86	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.63792462
87	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.63735054
88	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.63236577
89	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	0.62604813
90	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.62484148
91	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.62104528
92	CDX2_22108803_ChIP-Seq_LS180_Human	0.61869888
93	DROSHA_22980978_ChIP-Seq_HELA_Human	0.61859451
94	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.61819687
95	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.61036881
96	REST_21632747_ChIP-Seq_MESCs_Mouse	0.60391645
97	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.60276361
98	ZNF274_21170338_ChIP-Seq_K562_Hela	0.58428617
99	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.58344449
100	RNF2_27304074_Chip-Seq_NSC_Mouse	0.58309304

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003718_maternal_effect	8.52213331
2	MP0008877_abnormal_DNA_methylation	4.80903792
3	MP0006292_abnormal_olfactory_placode	4.69290104
4	MP0008789_abnormal_olfactory_epithelium	4.56913476
5	MP0005394_taste/olfaction_phenotype	3.99333371
6	MP0005499_abnormal_olfactory_system	3.99333371
7	MP0002139_abnormal_hepatobiliary_system	3.63806410
8	MP0005395_other_phenotype	3.34098393
9	MP0003890_abnormal_embryonic-extraembry	3.20319633
10	MP0002138_abnormal_hepatobiliary_system	2.93346126
11	MP0008057_abnormal_DNA_replication	2.87895520
12	MP0003693_abnormal_embryo_hatching	2.74005354
13	MP0010030_abnormal_orbit_morphology	2.59539911
14	MP0003699_abnormal_female_reproductive	2.57229772
15	MP0010234_abnormal_vibrissa_follicle	2.43835784
16	MP0005360_urolithiasis	2.43016045
17	MP0002234_abnormal_pharynx_morphology	2.40685282
18	MP0003183_abnormal_peptide_metabolism	2.38246609
19	MP0001929_abnormal_gametogenesis	2.21632872
20	MP0003879_abnormal_hair_cell	2.12478668
21	MP0008058_abnormal_DNA_repair	2.07526341
22	MP0002210_abnormal_sex_determination	2.04979682
23	MP0003077_abnormal_cell_cycle	2.01183678
24	MP0010094_abnormal_chromosome_stability	1.99276227
25	MP0005410_abnormal_fertilization	1.76255127
26	MP0000653_abnormal_sex_gland	1.68755720
27	MP0003950_abnormal_plasma_membrane	1.67986178
28	MP0002161_abnormal_fertility/fecundity	1.67703394
29	MP0010307_abnormal_tumor_latency	1.58838111
30	MP0003121_genomic_imprinting	1.58230813
31	MP0000566_synostosis	1.54916536
32	MP0003111_abnormal_nucleus_morphology	1.54677845
33	MP0001984_abnormal_olfaction	1.40813743
34	MP0001293_anophthalmia	1.39198451
35	MP0001119_abnormal_female_reproductive	1.35888692
36	MP0002160_abnormal_reproductive_system	1.34590834
37	MP0001730_embryonic_growth_arrest	1.32554867
38	MP0003252_abnormal_bile_duct	1.28906521
39	MP0001145_abnormal_male_reproductive	1.26115181
40	MP0008932_abnormal_embryonic_tissue	1.22111099
41	MP0005647_abnormal_sex_gland	1.17555410
42	MP0000762_abnormal_tongue_morphology	1.16350903
43	MP0002233_abnormal_nose_morphology	1.15632935
44	MP0005646_abnormal_pituitary_gland	1.15499926
45	MP0000631_abnormal_neuroendocrine_gland	1.14818690
46	MP0009840_abnormal_foam_cell	1.09577494
47	MP0003698_abnormal_male_reproductive	1.09357464
48	MP0005389_reproductive_system_phenotype	1.08060048
49	MP0010368_abnormal_lymphatic_system	1.07285863
50	MP0000427_abnormal_hair_cycle	1.03200057
51	MP0003119_abnormal_digestive_system	0.93858711
52	MP0005085_abnormal_gallbladder_physiolo	0.93100944
53	MP0005380_embryogenesis_phenotype	0.89419625
54	MP0001672_abnormal_embryogenesis/_devel	0.89419625
55	MP0010678_abnormal_skin_adnexa	0.88304288
56	MP0002272_abnormal_nervous_system	0.87731532
57	MP0001666_abnormal_nutrient_absorption	0.83036118
58	MP0003868_abnormal_feces_composition	0.82394644
59	MP0005551_abnormal_eye_electrophysiolog	0.82300813
60	MP0000350_abnormal_cell_proliferation	0.82020659
61	MP0004142_abnormal_muscle_tone	0.78477368
62	MP0001986_abnormal_taste_sensitivity	0.77865733
63	MP0001664_abnormal_digestion	0.77820026
64	MP0003136_yellow_coat_color	0.71571367
65	MP0001324_abnormal_eye_pigmentation	0.69361062
66	MP0006276_abnormal_autonomic_nervous	0.66416879
67	MP0000049_abnormal_middle_ear	0.65566122
68	MP0002396_abnormal_hematopoietic_system	0.60269667
69	MP0002928_abnormal_bile_duct	0.56276138
70	MP0002084_abnormal_developmental_patter	0.55921239
71	MP0004043_abnormal_pH_regulation	0.55325736
72	MP0004957_abnormal_blastocyst_morpholog	0.54760098
73	MP0002089_abnormal_postnatal_growth/wei	0.54190055
74	MP0001963_abnormal_hearing_physiology	0.51321910
75	MP0002796_impaired_skin_barrier	0.50438092
76	MP0000678_abnormal_parathyroid_gland	0.48393239
77	MP0001919_abnormal_reproductive_system	0.48366057
78	MP0001502_abnormal_circadian_rhythm	0.47825520
79	MP0000015_abnormal_ear_pigmentation	0.47254378
80	MP0002090_abnormal_vision	0.46535994
81	MP0005075_abnormal_melanosome_morpholog	0.45176365
82	MP0002127_abnormal_cardiovascular_syste	0.44341311
83	MP0003935_abnormal_craniofacial_develop	0.43130477
84	MP0005501_abnormal_skin_physiology	0.42022106
85	MP0003941_abnormal_skin_development	0.41952911
86	MP0002638_abnormal_pupillary_reflex	0.41683914
87	MP0000428_abnormal_craniofacial_morphol	0.41556029
88	MP0003755_abnormal_palate_morphology	0.41344477
89	MP0003959_abnormal_lean_body	0.40187509
90	MP0002085_abnormal_embryonic_tissue	0.38903284
91	MP0005503_abnormal_tendon_morphology	0.38322484
92	MP0000377_abnormal_hair_follicle	0.37137721
93	MP0005319_abnormal_enzyme/_coenzyme	0.35870596
94	MP0002751_abnormal_autonomic_nervous	0.35194615
95	MP0005076_abnormal_cell_differentiation	0.35173453
96	MP0002873_normal_phenotype	0.34809851
97	MP0002169_no_abnormal_phenotype	0.34264990
98	MP0002019_abnormal_tumor_incidence	0.33989468
99	MP0001697_abnormal_embryo_size	0.33865328
100	MP0003984_embryonic_growth_retardation	0.32704795

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Supernumerary spleens (HP:0009799)	6.43040690
2	Facial hemangioma (HP:0000329)	5.54529239
3	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	5.46091943
4	Abnormality of abdominal situs (HP:0011620)	5.21330224
5	Abdominal situs inversus (HP:0003363)	5.21330224
6	Abnormal gallbladder physiology (HP:0012438)	5.01360520
7	Cholecystitis (HP:0001082)	5.01360520
8	Aplasia/Hypoplasia of the fovea (HP:0008060)	4.84229073
9	Hypoplasia of the fovea (HP:0007750)	4.84229073
10	Osteomalacia (HP:0002749)	4.74521508
11	Impulsivity (HP:0100710)	4.73521462
12	Lip pit (HP:0100267)	4.68186614
13	Oligodactyly (hands) (HP:0001180)	4.64633192
14	Anterior segment dysgenesis (HP:0007700)	4.51644048
15	Septo-optic dysplasia (HP:0100842)	4.26028237
16	Chromsome breakage (HP:0040012)	4.24752354
17	Papillary thyroid carcinoma (HP:0002895)	4.20474982
18	Abnormality of the fovea (HP:0000493)	4.12005252
19	Hypophosphatemic rickets (HP:0004912)	4.07671567
20	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.99624525
21	Male infertility (HP:0003251)	3.79611236
22	Median cleft lip (HP:0000161)	3.78441094
23	Azoospermia (HP:0000027)	3.69038753
24	Abnormality of the labia minora (HP:0012880)	3.65640263
25	Infertility (HP:0000789)	3.62689404
26	Absent septum pellucidum (HP:0001331)	3.47031064
27	Capillary hemangiomas (HP:0005306)	3.35915571
28	Enlarged penis (HP:0000040)	3.34741113
29	Oligodactyly (HP:0012165)	3.32143030
30	Short tibia (HP:0005736)	3.28298657
31	Wrist flexion contracture (HP:0001239)	3.20969670
32	Hypokinesia (HP:0002375)	3.16774445
33	Apathy (HP:0000741)	3.16749670
34	Gonadotropin excess (HP:0000837)	3.16313861
35	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	3.14082288
36	Aplasia/Hypoplasia of the macula (HP:0008059)	3.06153492
37	Diminished motivation (HP:0000745)	3.03448650
38	Abnormality of the septum pellucidum (HP:0007375)	2.97708088
39	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.94299917
40	Fair hair (HP:0002286)	2.86304350
41	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.80506813
42	Malnutrition (HP:0004395)	2.79400977
43	Abnormal spermatogenesis (HP:0008669)	2.78845332
44	Truncal obesity (HP:0001956)	2.70178270
45	Premature ovarian failure (HP:0008209)	2.66646771
46	Spinal cord compression (HP:0002176)	2.58573548
47	Lower limb hyperreflexia (HP:0002395)	2.56795309
48	Stillbirth (HP:0003826)	2.50873955
49	Posterior subcapsular cataract (HP:0007787)	2.48490545
50	Intrahepatic cholestasis (HP:0001406)	2.45800616
51	Metaphyseal irregularity (HP:0003025)	2.44930926
52	Urethral obstruction (HP:0000796)	2.41583214
53	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.37747817
54	Bile duct proliferation (HP:0001408)	2.37727038
55	Abnormal biliary tract physiology (HP:0012439)	2.37727038
56	Thyroid carcinoma (HP:0002890)	2.36557779
57	Nephroblastoma (Wilms tumor) (HP:0002667)	2.31626090
58	Dysdiadochokinesis (HP:0002075)	2.31346501
59	Ankle contracture (HP:0006466)	2.30971712
60	Congenital sensorineural hearing impairment (HP:0008527)	2.30141936
61	Maternal diabetes (HP:0009800)	2.28644747
62	Abnormality of chromosome stability (HP:0003220)	2.27627011
63	Heterotopia (HP:0002282)	2.27331239
64	Striae distensae (HP:0001065)	2.25136159
65	Abnormality of the phalanges of the hallux (HP:0010057)	2.23487952
66	Abnormal ciliary motility (HP:0012262)	2.22752466
67	Aplasia of the musculature (HP:0100854)	2.22563020
68	Embryonal renal neoplasm (HP:0011794)	2.18657685
69	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.18406900
70	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.16208579
71	Skin pits (HP:0100276)	2.10074741
72	Proximal tubulopathy (HP:0000114)	2.08214345
73	Abnormal lung lobation (HP:0002101)	2.05389766
74	Conjunctival telangiectasia (HP:0000524)	2.03566879
75	Generalized hypopigmentation of hair (HP:0011358)	2.03191371
76	Abnormality of the preputium (HP:0100587)	2.00626170
77	Hypergonadotropic hypogonadism (HP:0000815)	1.99949690
78	Hip contracture (HP:0003273)	1.99637215
79	Subcapsular cataract (HP:0000523)	1.99493251
80	Meckel diverticulum (HP:0002245)	1.97777686
81	Anhidrosis (HP:0000970)	1.97311034
82	Myokymia (HP:0002411)	1.93471621
83	Loss of speech (HP:0002371)	1.93246932
84	Duodenal stenosis (HP:0100867)	1.93174484
85	Small intestinal stenosis (HP:0012848)	1.93174484
86	Abnormality of chromosome segregation (HP:0002916)	1.92531770
87	Bicornuate uterus (HP:0000813)	1.91941726
88	Microglossia (HP:0000171)	1.91908875
89	Bundle branch block (HP:0011710)	1.90733972
90	Sensory axonal neuropathy (HP:0003390)	1.90156423
91	Shallow orbits (HP:0000586)	1.87553021
92	Abnormality of the anterior chamber (HP:0000593)	1.87280005
93	Abnormality of the ileum (HP:0001549)	1.85841901
94	Muscle stiffness (HP:0003552)	1.84878602
95	Abnormality of monocarboxylic acid metabolism (HP:0010996)	1.81409834
96	Neoplasm of the oral cavity (HP:0100649)	1.81408034
97	Abnormal respiratory motile cilium physiology (HP:0012261)	1.81196213
98	Broad alveolar ridges (HP:0000187)	1.80756091
99	Cone-rod dystrophy (HP:0000548)	1.80392423
100	Optic nerve hypoplasia (HP:0000609)	1.79543204

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K9	6.14299918
2	MAP3K13	5.50796100
3	ARAF	5.46034634
4	NEK6	3.46554318
5	TAOK3	3.35558235
6	TTK	3.15958363
7	CDK9	3.10001624
8	BRAF	2.97915647
9	CDK12	2.95838657
10	STK24	2.84639517
11	AURKA	2.47293391
12	MET	2.39415511
13	MOS	2.38533104
14	CDC7	2.21806505
15	NTRK2	2.12164187
16	RAF1	1.87286555
17	PRKCI	1.87025024
18	KSR2	1.79610250
19	TNIK	1.73258387
20	EIF2AK3	1.51287387
21	CDK7	1.42820637
22	PLK1	1.41486732
23	MELK	1.38371139
24	STK3	1.26930819
25	KSR1	1.20913553
26	TRIM28	1.20256778
27	MST4	1.19038866
28	NUAK1	1.16187075
29	NEK9	1.14674537
30	MAP3K8	0.93195757
31	CHEK1	0.89965443
32	ZAK	0.88076455
33	NEK2	0.87893425
34	BUB1	0.87381237
35	BRSK1	0.85730244
36	MARK3	0.83603830
37	TNK2	0.83546509
38	STK39	0.83393328
39	PIM1	0.83118069
40	DMPK	0.79951054
41	CDK2	0.78501457
42	CSNK1G1	0.76951032
43	PLK3	0.76911252
44	TIE1	0.75113047
45	PTK2	0.74297234
46	AURKB	0.73643113
47	CHEK2	0.72322277
48	ATM	0.68367422
49	WNK1	0.68005709
50	BMPR1B	0.67873445
51	TGFBR1	0.67177395
52	CSNK1D	0.65163980
53	PRKG1	0.60506817
54	CDK1	0.58651157
55	MAPKAPK3	0.55361912
56	CDK8	0.55052219
57	MTOR	0.52976064
58	PRKCZ	0.52485775
59	MAPK13	0.51661036
60	CAMK1D	0.49991267
61	CSNK1G3	0.49798825
62	BRD4	0.48849644
63	CHUK	0.47103733
64	PAK1	0.46926183
65	ATR	0.45487460
66	CSNK1E	0.45033471
67	BRSK2	0.44532677
68	EEF2K	0.43731746
69	VRK1	0.42013651
70	PKN1	0.40995701
71	CAMK2A	0.40602330
72	NTRK3	0.37925329
73	PRKACB	0.37475848
74	CDK5	0.36922293
75	ACVR1B	0.36120951
76	PRKACA	0.34190692
77	CSNK1A1L	0.30798133
78	TYRO3	0.30295499
79	MAP3K4	0.29726455
80	PBK	0.29276736
81	CSNK1G2	0.28871674
82	GSK3B	0.28852410
83	MAPK1	0.28743164
84	LRRK2	0.26411673
85	OXSR1	0.26398674
86	MAP3K5	0.25033485
87	PLK4	0.20830022
88	CDK19	0.20808718
89	PDK1	0.20468520
90	EPHA4	0.20073754
91	MAPK10	0.18849767
92	CAMK1G	0.18408165
93	TRPM7	0.18233140
94	SRPK1	0.15953667
95	AKT2	0.13992273
96	LMTK2	0.12907665
97	EGFR	0.12028785
98	PRKAA2	0.10303188
99	PRKAA1	0.09315861
100	LATS1	0.08835419

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	5.10661237
2	Cell cycle_Homo sapiens_hsa04110	4.57356508
3	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.85235748
4	Ovarian steroidogenesis_Homo sapiens_hsa04913	3.73102812
5	Mismatch repair_Homo sapiens_hsa03430	3.50459303
6	Oocyte meiosis_Homo sapiens_hsa04114	3.41282296
7	Caffeine metabolism_Homo sapiens_hsa00232	3.29580067
8	RNA degradation_Homo sapiens_hsa03018	2.92981941
9	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.58082587
10	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.56333776
11	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.53934402
12	Homologous recombination_Homo sapiens_hsa03440	2.52641639
13	Base excision repair_Homo sapiens_hsa03410	2.41284685
14	Fanconi anemia pathway_Homo sapiens_hsa03460	2.30651316
15	Nucleotide excision repair_Homo sapiens_hsa03420	2.29940464
16	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.14154968
17	Circadian rhythm_Homo sapiens_hsa04710	2.05203558
18	DNA replication_Homo sapiens_hsa03030	2.03246824
19	Olfactory transduction_Homo sapiens_hsa04740	1.87557676
20	RNA transport_Homo sapiens_hsa03013	1.80775461
21	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.74872678
22	p53 signaling pathway_Homo sapiens_hsa04115	1.73729634
23	Gap junction_Homo sapiens_hsa04540	1.64758550
24	Folate biosynthesis_Homo sapiens_hsa00790	1.57113744
25	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.44577919
26	Phototransduction_Homo sapiens_hsa04744	1.42203215
27	Thyroid cancer_Homo sapiens_hsa05216	1.34381684
28	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.27924194
29	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.21587726
30	ABC transporters_Homo sapiens_hsa02010	1.15715665
31	Nicotine addiction_Homo sapiens_hsa05033	1.13123989
32	mRNA surveillance pathway_Homo sapiens_hsa03015	1.01543036
33	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.99642894
34	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.96312693
35	Bile secretion_Homo sapiens_hsa04976	0.94157950
36	Morphine addiction_Homo sapiens_hsa05032	0.91138142
37	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.89394592
38	GABAergic synapse_Homo sapiens_hsa04727	0.88185809
39	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.80998573
40	mTOR signaling pathway_Homo sapiens_hsa04150	0.78916435
41	RNA polymerase_Homo sapiens_hsa03020	0.72248875
42	FoxO signaling pathway_Homo sapiens_hsa04068	0.67590643
43	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.60076494
44	Taste transduction_Homo sapiens_hsa04742	0.57378130
45	Adherens junction_Homo sapiens_hsa04520	0.55706115
46	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.54887889
47	Long-term depression_Homo sapiens_hsa04730	0.54263864
48	MicroRNAs in cancer_Homo sapiens_hsa05206	0.53442685
49	Purine metabolism_Homo sapiens_hsa00230	0.52959507
50	Serotonergic synapse_Homo sapiens_hsa04726	0.51194058
51	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.51156133
52	Non-homologous end-joining_Homo sapiens_hsa03450	0.50062003
53	Fatty acid elongation_Homo sapiens_hsa00062	0.45241392
54	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.45160443
55	Herpes simplex infection_Homo sapiens_hsa05168	0.39259804
56	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.35870812
57	Viral carcinogenesis_Homo sapiens_hsa05203	0.35543103
58	Hippo signaling pathway_Homo sapiens_hsa04390	0.35402074
59	Small cell lung cancer_Homo sapiens_hsa05222	0.32780657
60	HTLV-I infection_Homo sapiens_hsa05166	0.32341393
61	Notch signaling pathway_Homo sapiens_hsa04330	0.30930594
62	Ras signaling pathway_Homo sapiens_hsa04014	0.30445361
63	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.30341300
64	ErbB signaling pathway_Homo sapiens_hsa04012	0.29641627
65	Wnt signaling pathway_Homo sapiens_hsa04310	0.29226906
66	cAMP signaling pathway_Homo sapiens_hsa04024	0.28285344
67	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.28095421
68	Endometrial cancer_Homo sapiens_hsa05213	0.26557133
69	Phagosome_Homo sapiens_hsa04145	0.24287115
70	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.24111963
71	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.23672552
72	Regulation of autophagy_Homo sapiens_hsa04140	0.21572162
73	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.21415878
74	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.21057451
75	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.19706233
76	Protein digestion and absorption_Homo sapiens_hsa04974	0.19641148
77	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.19178359
78	Lysine degradation_Homo sapiens_hsa00310	0.16626597
79	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.16149669
80	Renal cell carcinoma_Homo sapiens_hsa05211	0.15440364
81	Cholinergic synapse_Homo sapiens_hsa04725	0.14758786
82	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.13127995
83	Circadian entrainment_Homo sapiens_hsa04713	0.12522123
84	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.11549018
85	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.10973670
86	Propanoate metabolism_Homo sapiens_hsa00640	0.09972184
87	Glutamatergic synapse_Homo sapiens_hsa04724	0.09225011
88	Long-term potentiation_Homo sapiens_hsa04720	0.09007299
89	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.08018113
90	Huntingtons disease_Homo sapiens_hsa05016	0.07855812
91	Colorectal cancer_Homo sapiens_hsa05210	0.07756929
92	Arginine and proline metabolism_Homo sapiens_hsa00330	0.07558285
93	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.06591561
94	Dopaminergic synapse_Homo sapiens_hsa04728	0.06000491
95	Tight junction_Homo sapiens_hsa04530	0.05954812
96	Rap1 signaling pathway_Homo sapiens_hsa04015	0.05548858
97	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.05517771
98	Pathways in cancer_Homo sapiens_hsa05200	0.04782103
99	Melanogenesis_Homo sapiens_hsa04916	0.04767264
100	Arginine biosynthesis_Homo sapiens_hsa00220	0.04530731

ZNF840P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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