ZNF841

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to Golgi (GO:0072600)5.04976807
2protein K11-linked deubiquitination (GO:0035871)4.71348380
3protein targeting to Golgi (GO:0000042)4.67767455
4cytoplasmic mRNA processing body assembly (GO:0033962)4.51519351
5neural tube formation (GO:0001841)4.48581146
6retrograde transport, vesicle recycling within Golgi (GO:0000301)4.36252107
7regulation of cilium movement (GO:0003352)4.23963504
8UDP-N-acetylglucosamine metabolic process (GO:0006047)3.97157270
9regulation of hippo signaling (GO:0035330)3.94802250
10response to pheromone (GO:0019236)3.87232720
11regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.83921852
12protein localization to Golgi apparatus (GO:0034067)3.78105067
13microtubule anchoring (GO:0034453)3.76809775
14acrosome assembly (GO:0001675)3.63641966
15intra-Golgi vesicle-mediated transport (GO:0006891)3.63492344
16cilium morphogenesis (GO:0060271)3.63182866
17negative regulation of translation, ncRNA-mediated (GO:0040033)3.56959169
18regulation of translation, ncRNA-mediated (GO:0045974)3.56959169
19negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.56959169
20histone mRNA catabolic process (GO:0071044)3.55155743
21cellular response to ethanol (GO:0071361)3.46125622
22nonmotile primary cilium assembly (GO:0035058)3.41816139
23negative regulation of systemic arterial blood pressure (GO:0003085)3.39172268
24maintenance of protein location in nucleus (GO:0051457)3.23560662
25regulation of memory T cell differentiation (GO:0043380)3.20452821
26regulation of telomere maintenance (GO:0032204)3.19551927
27protein K48-linked deubiquitination (GO:0071108)3.18719788
28regulation of hexokinase activity (GO:1903299)3.15354996
29regulation of glucokinase activity (GO:0033131)3.15354996
30histone H3-K4 trimethylation (GO:0080182)3.13399551
31monoubiquitinated protein deubiquitination (GO:0035520)3.12020590
32interkinetic nuclear migration (GO:0022027)3.05864241
33protein localization to cilium (GO:0061512)2.99780759
34negative regulation of mast cell activation (GO:0033004)2.99599667
35L-fucose catabolic process (GO:0042355)2.99238035
36fucose catabolic process (GO:0019317)2.99238035
37L-fucose metabolic process (GO:0042354)2.99238035
38epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.95709128
39protein K63-linked deubiquitination (GO:0070536)2.91500015
40positive regulation of chemokine secretion (GO:0090197)2.91383612
41gamma-aminobutyric acid transport (GO:0015812)2.91242555
42protein localization to microtubule cytoskeleton (GO:0072698)2.90238916
43iron ion import (GO:0097286)2.89878170
44negative regulation of axon guidance (GO:1902668)2.89145517
45platelet dense granule organization (GO:0060155)2.87764684
46histone H3-K9 methylation (GO:0051567)2.87107000
47prenylation (GO:0097354)2.86313153
48protein prenylation (GO:0018342)2.86313153
49peptidyl-lysine trimethylation (GO:0018023)2.86007878
50regulation of establishment of cell polarity (GO:2000114)2.85371302
51nephron tubule morphogenesis (GO:0072078)2.83582546
52nephron epithelium morphogenesis (GO:0072088)2.83582546
53early endosome to late endosome transport (GO:0045022)2.83145084
54regulation of establishment or maintenance of cell polarity (GO:0032878)2.83107126
55regulation of protein polyubiquitination (GO:1902914)2.81227932
56response to lipoprotein particle (GO:0055094)2.79631882
57spermatid nucleus differentiation (GO:0007289)2.79308908
58photoreceptor cell development (GO:0042461)2.76162172
59regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.75876805
60protein localization to cytoskeleton (GO:0044380)2.75732743
61negative regulation of axon extension involved in axon guidance (GO:0048843)2.74196482
62protein polyglutamylation (GO:0018095)2.72916386
63RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.69473495
64macroautophagy (GO:0016236)2.69467471
65protein targeting to vacuole (GO:0006623)2.68367061
66protein targeting to lysosome (GO:0006622)2.68367061
67establishment of protein localization to vacuole (GO:0072666)2.68367061
68sulfation (GO:0051923)2.68255589
69negative regulation of macrophage differentiation (GO:0045650)2.65688549
70adaptation of signaling pathway (GO:0023058)2.64344423
71cilium organization (GO:0044782)2.62593208
72endocrine hormone secretion (GO:0060986)2.61363615
73regulation of MHC class I biosynthetic process (GO:0045343)2.60976191
74photoreceptor cell maintenance (GO:0045494)2.60576568
75eye photoreceptor cell development (GO:0042462)2.59633627
76water-soluble vitamin biosynthetic process (GO:0042364)2.57112485
77cilium assembly (GO:0042384)2.55876331
78renal tubule morphogenesis (GO:0061333)2.55259322
79cellular response to sterol (GO:0036315)2.54729980
80COPII vesicle coating (GO:0048208)2.53436128
81positive regulation of mRNA catabolic process (GO:0061014)2.53036152
82phospholipid translocation (GO:0045332)2.51496072
83lipid translocation (GO:0034204)2.51496072
84cAMP catabolic process (GO:0006198)2.51022388
85cellular ketone body metabolic process (GO:0046950)2.49835131
86nerve growth factor signaling pathway (GO:0038180)2.49440024
87phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.47699973
88regulation of microtubule-based movement (GO:0060632)2.44878480
89positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.44442153
90regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.44442153
91regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.40972201
92positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.40972201
93detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.39521398
94positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)2.39368259
95tryptophan metabolic process (GO:0006568)2.39262391
96regulation of interleukin-12 biosynthetic process (GO:0045075)2.37195338
97ovulation from ovarian follicle (GO:0001542)2.36145799
98indole-containing compound catabolic process (GO:0042436)2.34159672
99indolalkylamine catabolic process (GO:0046218)2.34159672
100tryptophan catabolic process (GO:0006569)2.34159672

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.96952233
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.24951382
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.09669318
4POU3F2_20337985_ChIP-ChIP_501MEL_Human2.81312189
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.75363785
6GBX2_23144817_ChIP-Seq_PC3_Human2.66891285
7VDR_22108803_ChIP-Seq_LS180_Human2.57758071
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.53222923
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.52427985
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.30361895
11AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.29484411
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.25287277
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.24584525
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.14606288
15SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.13521884
16TAF15_26573619_Chip-Seq_HEK293_Human2.08976439
17PIAS1_25552417_ChIP-Seq_VCAP_Human2.08806832
18FUS_26573619_Chip-Seq_HEK293_Human2.01219482
19ER_23166858_ChIP-Seq_MCF-7_Human1.98101653
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.93247164
21IGF1R_20145208_ChIP-Seq_DFB_Human1.85281214
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.84592961
23EWS_26573619_Chip-Seq_HEK293_Human1.82202597
24STAT3_23295773_ChIP-Seq_U87_Human1.82088515
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81965047
26P300_19829295_ChIP-Seq_ESCs_Human1.79526839
27SMAD4_21799915_ChIP-Seq_A2780_Human1.75352901
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.73523947
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.70823214
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.66735966
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59324302
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58799483
33TP53_16413492_ChIP-PET_HCT116_Human1.58461661
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.58445397
35CBP_20019798_ChIP-Seq_JUKART_Human1.56656056
36IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56656056
37TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.56250988
38* TCF4_23295773_ChIP-Seq_U87_Human1.52171258
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51107673
40ELK1_19687146_ChIP-ChIP_HELA_Human1.50203137
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47733942
42EZH2_27294783_Chip-Seq_NPCs_Mouse1.44549403
43OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43587975
44BCAT_22108803_ChIP-Seq_LS180_Human1.43230067
45AR_25329375_ChIP-Seq_VCAP_Human1.42564966
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41911702
47SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41678695
48AR_21572438_ChIP-Seq_LNCaP_Human1.41263290
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38148955
50NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35679558
51STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.34762556
52CDX2_22108803_ChIP-Seq_LS180_Human1.34185145
53ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33104892
54TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32104527
55CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.31042691
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27382340
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27382340
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.26401342
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.26100941
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.25964950
61EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22019192
62RUNX2_22187159_ChIP-Seq_PCA_Human1.21319010
63HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20676760
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20551877
65AHR_22903824_ChIP-Seq_MCF-7_Human1.20383473
66CRX_20693478_ChIP-Seq_RETINA_Mouse1.17801676
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17674449
68CJUN_26792858_Chip-Seq_BT549_Human1.16697097
69FLI1_21867929_ChIP-Seq_TH2_Mouse1.15082940
70KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14189185
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13562082
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.13461468
73CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.11511730
74IRF8_22096565_ChIP-ChIP_GC-B_Human1.10833769
75IRF1_19129219_ChIP-ChIP_H3396_Human1.10553586
76PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10521697
77CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10387553
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10299366
79TCF4_22108803_ChIP-Seq_LS180_Human1.09881127
80E2F1_18555785_Chip-Seq_ESCs_Mouse1.09421467
81NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09240322
82NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09240322
83PRDM14_20953172_ChIP-Seq_ESCs_Human1.07997214
84HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07656955
85WT1_19549856_ChIP-ChIP_CCG9911_Human1.06117731
86FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05815180
87VDR_23849224_ChIP-Seq_CD4+_Human1.04489584
88KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04399844
89EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04243181
90BRD4_25478319_ChIP-Seq_HGPS_Human1.03539291
91OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03268450
92P53_22387025_ChIP-Seq_ESCs_Mouse1.03093883
93FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01399083
94SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.00892129
95ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00844511
96ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99209697
97RXR_22108803_ChIP-Seq_LS180_Human0.98888563
98SMAD4_21741376_ChIP-Seq_EPCs_Human0.97378000
99STAT3_18555785_Chip-Seq_ESCs_Mouse0.97243751
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96999901

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.98695358
2MP0003950_abnormal_plasma_membrane4.44760236
3MP0008877_abnormal_DNA_methylation3.83681137
4MP0005187_abnormal_penis_morphology3.29149420
5MP0008995_early_reproductive_senescence3.02935065
6MP0008057_abnormal_DNA_replication2.93133831
7MP0000427_abnormal_hair_cycle2.65114278
8MP0005645_abnormal_hypothalamus_physiol2.44995477
9MP0001984_abnormal_olfaction2.43060298
10MP0000383_abnormal_hair_follicle2.37833857
11MP0003122_maternal_imprinting2.34762145
12MP0004043_abnormal_pH_regulation1.94559326
13MP0006072_abnormal_retinal_apoptosis1.90576020
14MP0002102_abnormal_ear_morphology1.83610792
15MP0002009_preneoplasia1.83514161
16MP0005551_abnormal_eye_electrophysiolog1.79821679
17MP0005171_absent_coat_pigmentation1.75402264
18MP0003121_genomic_imprinting1.75369192
19MP0001986_abnormal_taste_sensitivity1.75161585
20MP0003011_delayed_dark_adaptation1.72653228
21MP0002095_abnormal_skin_pigmentation1.69632897
22MP0003656_abnormal_erythrocyte_physiolo1.66507510
23MP0000647_abnormal_sebaceous_gland1.66007095
24MP0005253_abnormal_eye_physiology1.64009796
25MP0000015_abnormal_ear_pigmentation1.60528749
26MP0000013_abnormal_adipose_tissue1.59155725
27MP0005174_abnormal_tail_pigmentation1.55525901
28MP0000371_diluted_coat_color1.55380944
29MP0000372_irregular_coat_pigmentation1.50510571
30MP0003787_abnormal_imprinting1.50393388
31MP0005310_abnormal_salivary_gland1.47822335
32MP0006054_spinal_hemorrhage1.39542440
33MP0004134_abnormal_chest_morphology1.39011817
34MP0003136_yellow_coat_color1.33262453
35MP0001501_abnormal_sleep_pattern1.32641804
36MP0005408_hypopigmentation1.30142917
37MP0003646_muscle_fatigue1.29195917
38MP0009046_muscle_twitch1.27449816
39MP0010678_abnormal_skin_adnexa1.26582171
40MP0000613_abnormal_salivary_gland1.24178301
41MP0004142_abnormal_muscle_tone1.23326360
42MP0003786_premature_aging1.22927136
43MP0008775_abnormal_heart_ventricle1.22766177
44MP0001968_abnormal_touch/_nociception1.22697253
45MP0003252_abnormal_bile_duct1.15325410
46MP0002166_altered_tumor_susceptibility1.13445355
47MP0002928_abnormal_bile_duct1.12843642
48MP0002006_tumorigenesis1.12442269
49MP0002751_abnormal_autonomic_nervous1.10749793
50MP0001324_abnormal_eye_pigmentation1.07919674
51MP0002876_abnormal_thyroid_physiology1.03157477
52MP0002736_abnormal_nociception_after1.02596175
53MP0002735_abnormal_chemical_nociception1.02088927
54MP0005167_abnormal_blood-brain_barrier1.01872539
55MP0006276_abnormal_autonomic_nervous1.00674852
56MP0002168_other_aberrant_phenotype1.00663171
57MP0002909_abnormal_adrenal_gland0.98714265
58MP0008058_abnormal_DNA_repair0.89297300
59MP0008789_abnormal_olfactory_epithelium0.89113319
60MP0009780_abnormal_chondrocyte_physiolo0.88720868
61MP0002184_abnormal_innervation0.88686054
62MP0003195_calcinosis0.87375115
63MP0000516_abnormal_urinary_system0.86023308
64MP0005367_renal/urinary_system_phenotyp0.86023308
65MP0005646_abnormal_pituitary_gland0.84123393
66MP0003890_abnormal_embryonic-extraembry0.83715220
67MP0005394_taste/olfaction_phenotype0.83448399
68MP0005499_abnormal_olfactory_system0.83448399
69MP0003045_fibrosis0.82050942
70MP0003868_abnormal_feces_composition0.80724927
71MP0003937_abnormal_limbs/digits/tail_de0.80605298
72MP0001299_abnormal_eye_distance/0.77801815
73MP0005275_abnormal_skin_tensile0.77284983
74MP0005386_behavior/neurological_phenoty0.76315252
75MP0004924_abnormal_behavior0.76315252
76MP0002234_abnormal_pharynx_morphology0.75839478
77MP0009697_abnormal_copulation0.75197515
78MP0006292_abnormal_olfactory_placode0.74989115
79MP0002098_abnormal_vibrissa_morphology0.73428609
80MP0002075_abnormal_coat/hair_pigmentati0.72935300
81MP0003385_abnormal_body_wall0.72542624
82MP0004264_abnormal_extraembryonic_tissu0.71641586
83MP0001919_abnormal_reproductive_system0.71556018
84MP0001756_abnormal_urination0.70679137
85MP0002295_abnormal_pulmonary_circulatio0.70574349
86MP0000778_abnormal_nervous_system0.69888968
87MP0001873_stomach_inflammation0.69320068
88MP0003183_abnormal_peptide_metabolism0.68961679
89MP0003943_abnormal_hepatobiliary_system0.67201319
90MP0003755_abnormal_palate_morphology0.66464164
91MP0009764_decreased_sensitivity_to0.66432207
92MP0001929_abnormal_gametogenesis0.65523063
93MP0004808_abnormal_hematopoietic_stem0.65046968
94MP0001502_abnormal_circadian_rhythm0.64778561
95MP0001119_abnormal_female_reproductive0.63624136
96MP0005195_abnormal_posterior_eye0.63345659
97MP0001879_abnormal_lymphatic_vessel0.62136363
98MP0004885_abnormal_endolymph0.61365797
99MP0000639_abnormal_adrenal_gland0.61365176
100MP0002938_white_spotting0.61158146

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.98879355
2Genetic anticipation (HP:0003743)3.97506211
3Abnormality of midbrain morphology (HP:0002418)3.90694694
4Molar tooth sign on MRI (HP:0002419)3.90694694
5Hyperventilation (HP:0002883)3.80554228
6Chronic hepatic failure (HP:0100626)3.78583170
7Pancreatic fibrosis (HP:0100732)3.42327019
8Abnormality of the renal cortex (HP:0011035)3.40114208
9Medial flaring of the eyebrow (HP:0010747)3.26659665
10True hermaphroditism (HP:0010459)3.22139973
11Nephronophthisis (HP:0000090)3.21884955
12Renal cortical cysts (HP:0000803)3.08851161
13Absent speech (HP:0001344)3.07338390
14Congenital primary aphakia (HP:0007707)3.06893918
15Gait imbalance (HP:0002141)3.06457080
16Abnormality of the renal medulla (HP:0100957)3.04826487
17Nephrogenic diabetes insipidus (HP:0009806)3.00575750
18Poor coordination (HP:0002370)2.88662984
19Progressive cerebellar ataxia (HP:0002073)2.78940451
20Protruding tongue (HP:0010808)2.77995412
21Gaze-evoked nystagmus (HP:0000640)2.76926294
22Fair hair (HP:0002286)2.67921819
23Tubular atrophy (HP:0000092)2.64486305
24Abnormality of the nasal septum (HP:0000419)2.61970497
25Drooling (HP:0002307)2.60072834
26Generalized hypopigmentation of hair (HP:0011358)2.55136104
27Vaginal atresia (HP:0000148)2.45684894
28Large for gestational age (HP:0001520)2.44875478
29Widely spaced teeth (HP:0000687)2.44744363
30Genital tract atresia (HP:0001827)2.41973301
31Excessive salivation (HP:0003781)2.38461028
32Stomach cancer (HP:0012126)2.38427689
33Intestinal atresia (HP:0011100)2.36140201
34Broad-based gait (HP:0002136)2.34879216
35Cystic liver disease (HP:0006706)2.29096865
36Aplasia/Hypoplasia of the tibia (HP:0005772)2.28821904
37Methylmalonic acidemia (HP:0002912)2.27035631
38Keratoconus (HP:0000563)2.21654884
39Increased corneal curvature (HP:0100692)2.21654884
40Thyroiditis (HP:0100646)2.20326009
41Hypoplastic labia majora (HP:0000059)2.16321875
42Aplasia/Hypoplasia of the tongue (HP:0010295)2.13885416
43Furrowed tongue (HP:0000221)2.12809648
44Progressive inability to walk (HP:0002505)2.10771790
45Short foot (HP:0001773)2.09364177
46Hip dysplasia (HP:0001385)2.04110291
47Hypothermia (HP:0002045)2.03473055
48Tented upper lip vermilion (HP:0010804)2.02059562
49Volvulus (HP:0002580)2.01341291
50Aplasia/Hypoplasia of the lens (HP:0008063)2.01234053
51Abnormality of the labia majora (HP:0012881)2.00615503
52Postaxial foot polydactyly (HP:0001830)2.00612802
53Neonatal respiratory distress (HP:0002643)1.99185119
54Increased number of teeth (HP:0011069)1.96392186
55Tubulointerstitial nephritis (HP:0001970)1.93760265
56Neoplasm of the tracheobronchial system (HP:0100552)1.93285472
57Albinism (HP:0001022)1.92874496
58Ectropion (HP:0000656)1.92577862
59Decreased testicular size (HP:0008734)1.92354647
60Congenital hepatic fibrosis (HP:0002612)1.91925088
61Delayed puberty (HP:0000823)1.91859937
62Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.90555842
63Abnormality of alanine metabolism (HP:0010916)1.90555842
64Hyperalaninemia (HP:0003348)1.90555842
65Postaxial hand polydactyly (HP:0001162)1.90315148
66Labial hypoplasia (HP:0000066)1.88525826
67Febrile seizures (HP:0002373)1.87556104
68Astrocytoma (HP:0009592)1.86711940
69Abnormality of the astrocytes (HP:0100707)1.86711940
70Hypoplastic iliac wings (HP:0002866)1.85304865
71Clumsiness (HP:0002312)1.85204780
72Pendular nystagmus (HP:0012043)1.84717162
73Narrow forehead (HP:0000341)1.83335870
74Alveolar cell carcinoma (HP:0006519)1.81118836
75Abnormality of incisor morphology (HP:0011063)1.80725932
76Glioma (HP:0009733)1.80150676
77Prominent nasal bridge (HP:0000426)1.79765844
78Epidermoid cyst (HP:0200040)1.78871510
79Astigmatism (HP:0000483)1.77501964
80Severe Myopia (HP:0011003)1.77443479
81Attenuation of retinal blood vessels (HP:0007843)1.76479981
82Failure to thrive in infancy (HP:0001531)1.74833363
83Congenital stationary night blindness (HP:0007642)1.73666497
84Macroglossia (HP:0000158)1.71819709
85Hypoplastic nipples (HP:0002557)1.71063315
86Fibular hypoplasia (HP:0003038)1.70777086
87Fibular aplasia (HP:0002990)1.69464530
88Broad ribs (HP:0000885)1.69380911
89Short tibia (HP:0005736)1.68828053
90Highly arched eyebrow (HP:0002553)1.68205621
91Exotropia (HP:0000577)1.67861467
92Disproportionate short-trunk short stature (HP:0003521)1.67048843
93Pachygyria (HP:0001302)1.66317208
94Thyroid-stimulating hormone excess (HP:0002925)1.66195024
95Lissencephaly (HP:0001339)1.65324915
96Abnormality of the vitamin B12 metabolism (HP:0004341)1.65263697
97Narrow palate (HP:0000189)1.65249890
98Tapered finger (HP:0001182)1.65152050
99Hepatoblastoma (HP:0002884)1.63731067
100Blue irides (HP:0000635)1.63721005

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.56389339
2CASK3.14323557
3EPHA32.95217641
4AKT32.79790000
5MAP4K22.37422575
6TRIM282.17068279
7TAOK32.13395245
8BCR2.11577505
9NUAK12.07709613
10EIF2AK31.90344054
11MAP3K41.88405476
12LATS11.84456551
13CAMK1D1.80236520
14PAK31.76443178
15PINK11.76434194
16STK38L1.73128017
17BMPR1B1.72675977
18ADRBK21.71923099
19BRSK21.71760206
20ZAK1.67729014
21ACVR1B1.67673932
22BRD41.66710802
23SIK21.62272147
24GRK11.52922438
25WNK41.51253867
26CAMK1G1.37707589
27WNK31.34706131
28MAPK131.34037784
29TLK11.28072512
30STK31.25273100
31SIK31.23186265
32FER1.22967253
33MKNK21.19473321
34SGK21.14906058
35IRAK11.10381502
36TIE11.03321134
37MARK11.02460428
38CLK11.01598369
39FGFR30.97488711
40ERBB30.96705906
41TEC0.96114997
42CHUK0.94390896
43PRKCE0.89058289
44JAK10.87976949
45CAMKK20.87653194
46MARK30.86772291
47TRPM70.85237374
48INSRR0.82729296
49NLK0.82168670
50STK380.80915202
51FGFR10.80913664
52IKBKE0.79980167
53PIK3CA0.79062679
54IRAK40.76028135
55FLT30.73554829
56PKN20.72401787
57STK240.69766843
58WNK10.69183423
59FGFR20.67964622
60SGK2230.65395750
61SGK4940.65395750
62PRKCH0.62419535
63PRKAA10.61982088
64SGK30.61115752
65PKN10.58569971
66TXK0.56899705
67ABL10.55822364
68RPS6KA50.55391604
69PDGFRB0.55207791
70ERBB20.55051627
71ERBB40.54928539
72PRKAA20.53442151
73IKBKB0.53417858
74STK390.53314117
75PNCK0.52701495
76PIM10.51474320
77OXSR10.51017470
78YES10.49341043
79TNIK0.47193605
80CSNK1A1L0.46648313
81PLK20.46171741
82PRKCQ0.44524346
83TGFBR10.44426617
84ATM0.43348558
85MAP2K70.42782991
86CDK120.40041477
87FGFR40.39698350
88BMPR20.39416783
89HCK0.38409213
90MAPK80.37598950
91CSNK1D0.37441064
92PRKD20.37233326
93DYRK1A0.36371105
94ADRBK10.36016911
95SGK10.34624435
96PTK2B0.33702693
97NTRK30.33307452
98CDK30.32722984
99LCK0.32353477
100NTRK20.31568157

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030222.28901897
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.28153304
3Butanoate metabolism_Homo sapiens_hsa006502.13209130
4Propanoate metabolism_Homo sapiens_hsa006402.10436107
5Non-homologous end-joining_Homo sapiens_hsa034502.07690589
6Dorso-ventral axis formation_Homo sapiens_hsa043202.06337476
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.04800730
8Selenocompound metabolism_Homo sapiens_hsa004502.04750914
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.04311589
10ABC transporters_Homo sapiens_hsa020101.98859864
11Fanconi anemia pathway_Homo sapiens_hsa034601.96510352
12Nicotine addiction_Homo sapiens_hsa050331.81463104
13Fatty acid biosynthesis_Homo sapiens_hsa000611.80109326
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.74142308
15Ether lipid metabolism_Homo sapiens_hsa005651.73493274
16Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.70191827
17Linoleic acid metabolism_Homo sapiens_hsa005911.69914154
18Taste transduction_Homo sapiens_hsa047421.67184789
19Circadian rhythm_Homo sapiens_hsa047101.56026290
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.53139598
21Protein export_Homo sapiens_hsa030601.43382395
22Lysine degradation_Homo sapiens_hsa003101.43336195
23RNA degradation_Homo sapiens_hsa030181.39339316
24Nitrogen metabolism_Homo sapiens_hsa009101.37333000
25Phototransduction_Homo sapiens_hsa047441.36624127
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34368105
27Homologous recombination_Homo sapiens_hsa034401.33465375
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29792700
29Regulation of autophagy_Homo sapiens_hsa041401.28697550
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.26462574
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.18962733
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.14526461
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.11248552
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.09781514
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09270330
36Sphingolipid metabolism_Homo sapiens_hsa006001.08530119
37p53 signaling pathway_Homo sapiens_hsa041151.05241426
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.05132046
39RNA polymerase_Homo sapiens_hsa030201.05076920
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.04600523
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.01267038
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00863932
43Morphine addiction_Homo sapiens_hsa050320.99056630
44Olfactory transduction_Homo sapiens_hsa047400.93823545
45Inositol phosphate metabolism_Homo sapiens_hsa005620.93709698
46TGF-beta signaling pathway_Homo sapiens_hsa043500.92038912
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90343038
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89631303
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.88705890
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84734257
51Glycerolipid metabolism_Homo sapiens_hsa005610.84418027
52GABAergic synapse_Homo sapiens_hsa047270.80700143
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80251988
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78412498
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76954009
56Ovarian steroidogenesis_Homo sapiens_hsa049130.75971254
57Mineral absorption_Homo sapiens_hsa049780.75940735
58FoxO signaling pathway_Homo sapiens_hsa040680.69957631
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68251023
60Axon guidance_Homo sapiens_hsa043600.68172874
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67867830
62Sulfur metabolism_Homo sapiens_hsa009200.65505595
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.64571059
64One carbon pool by folate_Homo sapiens_hsa006700.64372833
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.62613761
66Glutamatergic synapse_Homo sapiens_hsa047240.58816692
67Steroid biosynthesis_Homo sapiens_hsa001000.58487643
68Measles_Homo sapiens_hsa051620.53111933
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51737879
70Serotonergic synapse_Homo sapiens_hsa047260.51365891
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.48903097
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48279333
73Choline metabolism in cancer_Homo sapiens_hsa052310.47685765
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47447219
75Peroxisome_Homo sapiens_hsa041460.45877816
76Circadian entrainment_Homo sapiens_hsa047130.45080863
77RNA transport_Homo sapiens_hsa030130.43260636
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43043835
79Salivary secretion_Homo sapiens_hsa049700.42977212
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42804272
81Arachidonic acid metabolism_Homo sapiens_hsa005900.42705949
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42372452
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.42321755
84Retinol metabolism_Homo sapiens_hsa008300.41750181
85MAPK signaling pathway_Homo sapiens_hsa040100.41151471
86Calcium signaling pathway_Homo sapiens_hsa040200.40807185
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39101211
88Insulin resistance_Homo sapiens_hsa049310.38137319
89Caffeine metabolism_Homo sapiens_hsa002320.37821942
90Systemic lupus erythematosus_Homo sapiens_hsa053220.37651423
91Tight junction_Homo sapiens_hsa045300.37244078
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.37190324
93Dopaminergic synapse_Homo sapiens_hsa047280.36655498
94Type II diabetes mellitus_Homo sapiens_hsa049300.35836165
95TNF signaling pathway_Homo sapiens_hsa046680.35551138
96Hepatitis C_Homo sapiens_hsa051600.35537600
97Long-term depression_Homo sapiens_hsa047300.35496605
98MicroRNAs in cancer_Homo sapiens_hsa052060.34915495
99Hippo signaling pathway_Homo sapiens_hsa043900.34913021
100Ras signaling pathway_Homo sapiens_hsa040140.34451601

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