ZNF843

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.75761502
2DNA deamination (GO:0045006)5.53702740
3response to pheromone (GO:0019236)4.61895065
4cytidine deamination (GO:0009972)4.44079584
5cytidine metabolic process (GO:0046087)4.44079584
6cytidine catabolic process (GO:0006216)4.44079584
7fucose catabolic process (GO:0019317)4.09768354
8L-fucose metabolic process (GO:0042354)4.09768354
9L-fucose catabolic process (GO:0042355)4.09768354
10pyrimidine ribonucleoside catabolic process (GO:0046133)3.93151979
11regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.84110688
12platelet dense granule organization (GO:0060155)3.69906678
13detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.48687564
14indolalkylamine metabolic process (GO:0006586)3.47697839
15water-soluble vitamin biosynthetic process (GO:0042364)3.41406598
16cellular ketone body metabolic process (GO:0046950)3.38255174
17negative regulation of telomere maintenance (GO:0032205)3.30053712
18protein complex biogenesis (GO:0070271)3.27599181
19protein neddylation (GO:0045116)3.24585688
20piRNA metabolic process (GO:0034587)3.23031494
21epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.22638915
22ATP synthesis coupled proton transport (GO:0015986)3.22404581
23energy coupled proton transport, down electrochemical gradient (GO:0015985)3.22404581
24mitochondrial respiratory chain complex I assembly (GO:0032981)3.18848167
25NADH dehydrogenase complex assembly (GO:0010257)3.18848167
26mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.18848167
27tryptophan catabolic process (GO:0006569)3.18480678
28indole-containing compound catabolic process (GO:0042436)3.18480678
29indolalkylamine catabolic process (GO:0046218)3.18480678
30kynurenine metabolic process (GO:0070189)3.16351796
31respiratory chain complex IV assembly (GO:0008535)3.10469685
32cornea development in camera-type eye (GO:0061303)3.09585017
33detection of light stimulus involved in sensory perception (GO:0050962)3.05395192
34detection of light stimulus involved in visual perception (GO:0050908)3.05395192
35ketone body metabolic process (GO:1902224)3.04778699
36mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.98155313
37mitochondrial respiratory chain complex assembly (GO:0033108)2.97377860
38mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.94711618
39epithelial cilium movement (GO:0003351)2.93909668
40axoneme assembly (GO:0035082)2.92538606
41phosphatidylinositol acyl-chain remodeling (GO:0036149)2.91345649
42adaptation of signaling pathway (GO:0023058)2.90702077
43ubiquinone biosynthetic process (GO:0006744)2.90360292
44regulation of nuclear cell cycle DNA replication (GO:0033262)2.90232003
45nonmotile primary cilium assembly (GO:0035058)2.87800471
46cytochrome complex assembly (GO:0017004)2.87139067
47sulfation (GO:0051923)2.84176969
48protein-cofactor linkage (GO:0018065)2.82425954
49tryptophan metabolic process (GO:0006568)2.81797158
50preassembly of GPI anchor in ER membrane (GO:0016254)2.81499158
51behavioral response to ethanol (GO:0048149)2.79654658
52protein polyglutamylation (GO:0018095)2.75942265
53negative regulation of mast cell activation (GO:0033004)2.75212172
54somite development (GO:0061053)2.74415106
55indole-containing compound metabolic process (GO:0042430)2.74112231
56regulation of rhodopsin mediated signaling pathway (GO:0022400)2.71647863
57ubiquinone metabolic process (GO:0006743)2.70420077
58neuronal action potential (GO:0019228)2.70192986
59synaptic transmission, cholinergic (GO:0007271)2.68050989
60tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.65947483
61RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.65947483
62S-adenosylmethionine metabolic process (GO:0046500)2.65780827
63kidney morphogenesis (GO:0060993)2.63772471
64male meiosis I (GO:0007141)2.63730853
65rhodopsin mediated signaling pathway (GO:0016056)2.63352088
66cilium morphogenesis (GO:0060271)2.63225621
67primary amino compound metabolic process (GO:1901160)2.61024112
68regulation of glucokinase activity (GO:0033131)2.58723314
69regulation of hexokinase activity (GO:1903299)2.58723314
70mannosylation (GO:0097502)2.57501995
71positive regulation of fatty acid transport (GO:2000193)2.55880755
72regulation of cilium movement (GO:0003352)2.55555189
73photoreceptor cell development (GO:0042461)2.55072305
74regulation of action potential (GO:0098900)2.53451347
75nephron tubule morphogenesis (GO:0072078)2.53224134
76nephron epithelium morphogenesis (GO:0072088)2.53224134
77DNA methylation involved in gamete generation (GO:0043046)2.50993849
78dopamine transport (GO:0015872)2.50944204
79electron transport chain (GO:0022900)2.48537405
80G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.48040484
81parturition (GO:0007567)2.47856337
82gamma-aminobutyric acid transport (GO:0015812)2.46987241
83GPI anchor metabolic process (GO:0006505)2.45962360
84positive regulation of defense response to virus by host (GO:0002230)2.45676657
85establishment of protein localization to mitochondrial membrane (GO:0090151)2.45373318
86serotonin metabolic process (GO:0042428)2.43890239
87multicellular organism reproduction (GO:0032504)2.43283866
88negative regulation of cytosolic calcium ion concentration (GO:0051481)2.40232206
89respiratory electron transport chain (GO:0022904)2.39970906
90negative regulation by host of viral transcription (GO:0043922)2.39832405
91pyrimidine nucleobase catabolic process (GO:0006208)2.39826790
92phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.39213745
93cellular response to ATP (GO:0071318)2.38656151
94transmission of nerve impulse (GO:0019226)2.38388284
95cilium movement (GO:0003341)2.37325517
96DNA demethylation (GO:0080111)2.36035109
97phosphatidylcholine acyl-chain remodeling (GO:0036151)2.33973025
98photoreceptor cell maintenance (GO:0045494)2.33167941
99auditory receptor cell stereocilium organization (GO:0060088)2.32640500
100reflex (GO:0060004)2.31591852

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.79115120
2VDR_22108803_ChIP-Seq_LS180_Human3.52152897
3EZH2_22144423_ChIP-Seq_EOC_Human3.16616934
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.75633673
5GBX2_23144817_ChIP-Seq_PC3_Human2.70673563
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.40787167
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.36466357
8IGF1R_20145208_ChIP-Seq_DFB_Human2.26740530
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.17145688
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06524846
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06012940
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04621538
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.04396221
14TAF15_26573619_Chip-Seq_HEK293_Human1.89828780
15FUS_26573619_Chip-Seq_HEK293_Human1.88758664
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.87778826
17P300_19829295_ChIP-Seq_ESCs_Human1.87146614
18EWS_26573619_Chip-Seq_HEK293_Human1.87027042
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85547138
20EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.83890646
21ER_23166858_ChIP-Seq_MCF-7_Human1.83326188
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.78102207
23GABP_17652178_ChIP-ChIP_JURKAT_Human1.74084839
24TP53_22573176_ChIP-Seq_HFKS_Human1.70996527
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68883629
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.66242595
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65122299
28MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.61784302
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60005904
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54220598
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.47288658
32BCAT_22108803_ChIP-Seq_LS180_Human1.46249279
33REST_21632747_ChIP-Seq_MESCs_Mouse1.45719088
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44525554
35CBP_20019798_ChIP-Seq_JUKART_Human1.44525554
36EST1_17652178_ChIP-ChIP_JURKAT_Human1.40920027
37FOXA1_27270436_Chip-Seq_PROSTATE_Human1.40631868
38FOXA1_25329375_ChIP-Seq_VCAP_Human1.40631868
39MYC_18940864_ChIP-ChIP_HL60_Human1.39847704
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38466558
41IRF1_19129219_ChIP-ChIP_H3396_Human1.38443823
42PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37941073
43NANOG_19829295_ChIP-Seq_ESCs_Human1.37783588
44SOX2_19829295_ChIP-Seq_ESCs_Human1.37783588
45GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.37215159
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.36917993
47* GATA3_21878914_ChIP-Seq_MCF-7_Human1.30061720
48AR_25329375_ChIP-Seq_VCAP_Human1.28315341
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28056121
50NCOR_22424771_ChIP-Seq_293T_Human1.28014381
51STAT3_23295773_ChIP-Seq_U87_Human1.27705927
52SMAD4_21799915_ChIP-Seq_A2780_Human1.26785429
53NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24835478
54TCF4_23295773_ChIP-Seq_U87_Human1.24743187
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24326631
56TCF4_22108803_ChIP-Seq_LS180_Human1.24222469
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23172733
58AR_20517297_ChIP-Seq_VCAP_Human1.21683795
59RNF2_27304074_Chip-Seq_NSC_Mouse1.20990429
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.20761441
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.20691811
62ETV2_25802403_ChIP-Seq_MESCs_Mouse1.20515528
63NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19367982
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18462255
65HOXB7_26014856_ChIP-Seq_BT474_Human1.17031676
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.16440127
67FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15519519
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14945513
69NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14149815
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13528653
71SMAD4_21741376_ChIP-Seq_EPCs_Human1.13494671
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12957074
73EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12943313
74KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12682182
75IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12149679
76VDR_23849224_ChIP-Seq_CD4+_Human1.11812761
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.11244791
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.10866320
79SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10361495
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08914781
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08914781
82TAF2_19829295_ChIP-Seq_ESCs_Human1.08677520
83EED_16625203_ChIP-ChIP_MESCs_Mouse1.08626789
84* PRDM14_20953172_ChIP-Seq_ESCs_Human1.06855979
85SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.06710458
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06682747
87MYC_19829295_ChIP-Seq_ESCs_Human1.06625905
88PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06371077
89* CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.05391602
90RUNX2_22187159_ChIP-Seq_PCA_Human1.04929268
91HTT_18923047_ChIP-ChIP_STHdh_Human1.04834529
92* ERA_21632823_ChIP-Seq_H3396_Human1.04546967
93FOXH1_21741376_ChIP-Seq_EPCs_Human1.03977591
94FLI1_21867929_ChIP-Seq_TH2_Mouse1.01910816
95LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99229464
96* NANOG_20526341_ChIP-Seq_ESCs_Human0.99034141
97CRX_20693478_ChIP-Seq_RETINA_Mouse0.97716318
98EZH2_27304074_Chip-Seq_ESCs_Mouse0.97473518
99JARID2_20064375_ChIP-Seq_MESCs_Mouse0.97430138
100EZH2_27294783_Chip-Seq_ESCs_Mouse0.97324726

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology2.74698734
2MP0003195_calcinosis2.74296834
3MP0005551_abnormal_eye_electrophysiolog2.57012544
4MP0003011_delayed_dark_adaptation2.47936985
5MP0001968_abnormal_touch/_nociception2.41210893
6MP0008877_abnormal_DNA_methylation2.25292640
7MP0002653_abnormal_ependyma_morphology2.20921744
8MP0005646_abnormal_pituitary_gland2.14924139
9MP0002837_dystrophic_cardiac_calcinosis2.12241365
10MP0006072_abnormal_retinal_apoptosis2.11680433
11MP0003136_yellow_coat_color2.08303401
12MP0002876_abnormal_thyroid_physiology2.05779521
13MP0003646_muscle_fatigue2.02844610
14MP0002736_abnormal_nociception_after1.99448641
15MP0009745_abnormal_behavioral_response1.97645042
16MP0005645_abnormal_hypothalamus_physiol1.97119058
17MP0008875_abnormal_xenobiotic_pharmacok1.96251644
18MP0008872_abnormal_physiological_respon1.94956593
19MP0001986_abnormal_taste_sensitivity1.94394209
20MP0004147_increased_porphyrin_level1.92374482
21MP0004885_abnormal_endolymph1.90056044
22MP0006292_abnormal_olfactory_placode1.85276194
23MP0001984_abnormal_olfaction1.82889616
24MP0005253_abnormal_eye_physiology1.78498422
25MP0000372_irregular_coat_pigmentation1.74716772
26MP0003880_abnormal_central_pattern1.69621052
27MP0009046_muscle_twitch1.68944620
28MP0002272_abnormal_nervous_system1.67304059
29MP0002638_abnormal_pupillary_reflex1.63575259
30MP0004145_abnormal_muscle_electrophysio1.61966550
31MP0005671_abnormal_response_to1.61520824
32MP0003787_abnormal_imprinting1.60843440
33MP0000569_abnormal_digit_pigmentation1.59454779
34MP0002735_abnormal_chemical_nociception1.58759301
35MP0006276_abnormal_autonomic_nervous1.58255665
36MP0004142_abnormal_muscle_tone1.54761000
37MP0005174_abnormal_tail_pigmentation1.50684854
38MP0001529_abnormal_vocalization1.50152039
39MP0001486_abnormal_startle_reflex1.49608135
40MP0004133_heterotaxia1.49556766
41MP0000631_abnormal_neuroendocrine_gland1.48683653
42MP0001501_abnormal_sleep_pattern1.47237061
43MP0002938_white_spotting1.45445195
44MP0002160_abnormal_reproductive_system1.44221681
45MP0005389_reproductive_system_phenotype1.41740226
46MP0004043_abnormal_pH_regulation1.41161914
47MP0001485_abnormal_pinna_reflex1.38749943
48MP0005084_abnormal_gallbladder_morpholo1.34419669
49MP0002064_seizures1.33912436
50MP0001970_abnormal_pain_threshold1.32889086
51MP0002733_abnormal_thermal_nociception1.32425569
52MP0001919_abnormal_reproductive_system1.29351818
53MP0001905_abnormal_dopamine_level1.27739750
54MP0002572_abnormal_emotion/affect_behav1.26118634
55MP0002277_abnormal_respiratory_mucosa1.26046285
56MP0000427_abnormal_hair_cycle1.19753282
57MP0003283_abnormal_digestive_organ1.18791844
58MP0005386_behavior/neurological_phenoty1.18161697
59MP0004924_abnormal_behavior1.18161697
60MP0002138_abnormal_hepatobiliary_system1.17103589
61MP0002557_abnormal_social/conspecific_i1.16711473
62MP0002163_abnormal_gland_morphology1.14101586
63MP0004742_abnormal_vestibular_system1.09821495
64MP0005423_abnormal_somatic_nervous1.09226809
65MP0002234_abnormal_pharynx_morphology1.09186902
66MP0003635_abnormal_synaptic_transmissio1.07608280
67MP0005379_endocrine/exocrine_gland_phen1.05944923
68MP0005195_abnormal_posterior_eye1.04505200
69MP0002928_abnormal_bile_duct1.04020934
70MP0001188_hyperpigmentation1.02839465
71MP0002063_abnormal_learning/memory/cond1.02140435
72MP0005377_hearing/vestibular/ear_phenot1.00975946
73MP0003878_abnormal_ear_physiology1.00975946
74MP0005075_abnormal_melanosome_morpholog1.00014648
75MP0010386_abnormal_urinary_bladder0.99565905
76MP0002067_abnormal_sensory_capabilities0.98680685
77MP0005410_abnormal_fertilization0.96178306
78MP0002734_abnormal_mechanical_nocicepti0.95423178
79MP0002095_abnormal_skin_pigmentation0.94155107
80MP0002693_abnormal_pancreas_physiology0.92729130
81MP0003137_abnormal_impulse_conducting0.90873720
82MP0002752_abnormal_somatic_nervous0.90471922
83MP0003567_abnormal_fetal_cardiomyocyte0.84753286
84MP0001502_abnormal_circadian_rhythm0.84588080
85MP0002751_abnormal_autonomic_nervous0.83146023
86MP0000230_abnormal_systemic_arterial0.81250507
87MP0000026_abnormal_inner_ear0.79919086
88MP0002909_abnormal_adrenal_gland0.78441302
89MP0001440_abnormal_grooming_behavior0.77834113
90MP0002229_neurodegeneration0.77099570
91MP0008775_abnormal_heart_ventricle0.76706162
92MP0002184_abnormal_innervation0.76665954
93MP0001293_anophthalmia0.76413544
94MP0008995_early_reproductive_senescence0.76009186
95MP0001324_abnormal_eye_pigmentation0.74572036
96MP0008789_abnormal_olfactory_epithelium0.73852544
97MP0001963_abnormal_hearing_physiology0.73780788
98MP0003698_abnormal_male_reproductive0.72179966
99MP0000647_abnormal_sebaceous_gland0.71929537
100MP0000383_abnormal_hair_follicle0.69307750

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.47398344
2Abnormality of midbrain morphology (HP:0002418)4.38765163
3Molar tooth sign on MRI (HP:0002419)4.38765163
4Pancreatic fibrosis (HP:0100732)4.17634777
5Congenital stationary night blindness (HP:0007642)4.00096543
6True hermaphroditism (HP:0010459)3.96548178
7Nephronophthisis (HP:0000090)3.41526517
8Type II lissencephaly (HP:0007260)3.19501563
9Abnormality of the renal cortex (HP:0011035)3.17034875
10Attenuation of retinal blood vessels (HP:0007843)3.10159862
11Chronic hepatic failure (HP:0100626)3.05086300
12Pendular nystagmus (HP:0012043)2.95627809
13Abnormality of the renal medulla (HP:0100957)2.93259196
14Abolished electroretinogram (ERG) (HP:0000550)2.91800146
15Cystic liver disease (HP:0006706)2.79940207
16Medial flaring of the eyebrow (HP:0010747)2.77439872
17Decreased central vision (HP:0007663)2.77369052
18Mitochondrial inheritance (HP:0001427)2.64010029
19Hyperventilation (HP:0002883)2.63086606
20Acute necrotizing encephalopathy (HP:0006965)2.61695352
21Abnormal rod and cone electroretinograms (HP:0008323)2.60049583
22Decreased electroretinogram (ERG) amplitude (HP:0000654)2.57632780
23Large for gestational age (HP:0001520)2.57548570
24Abnormal drinking behavior (HP:0030082)2.51692867
25Polydipsia (HP:0001959)2.51692867
26Increased corneal curvature (HP:0100692)2.47332224
27Keratoconus (HP:0000563)2.47332224
28Renal cortical cysts (HP:0000803)2.46844005
29Increased CSF lactate (HP:0002490)2.46483823
30Sclerocornea (HP:0000647)2.45053196
31Congenital, generalized hypertrichosis (HP:0004540)2.35020718
323-Methylglutaconic aciduria (HP:0003535)2.34534000
33Tubular atrophy (HP:0000092)2.33511700
34Progressive macrocephaly (HP:0004481)2.33406050
35Absent rod-and cone-mediated responses on ERG (HP:0007688)2.29310633
36Abnormal respiratory epithelium morphology (HP:0012253)2.27075818
37Abnormal respiratory motile cilium morphology (HP:0005938)2.27075818
38Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.23442208
39Abnormality of alanine metabolism (HP:0010916)2.23442208
40Hyperalaninemia (HP:0003348)2.23442208
41Abnormal mitochondria in muscle tissue (HP:0008316)2.22742000
42Congenital hepatic fibrosis (HP:0002612)2.21129665
43Dynein arm defect of respiratory motile cilia (HP:0012255)2.20775989
44Absent/shortened dynein arms (HP:0200106)2.20775989
45Acute encephalopathy (HP:0006846)2.20644578
46Gait imbalance (HP:0002141)2.19490693
47Inability to walk (HP:0002540)2.18725726
48Optic disc pallor (HP:0000543)2.17371237
49Abnormal biliary tract physiology (HP:0012439)2.16277562
50Bile duct proliferation (HP:0001408)2.16277562
51Anencephaly (HP:0002323)2.15095288
52Hepatocellular necrosis (HP:0001404)2.12573930
53Lipid accumulation in hepatocytes (HP:0006561)2.11698238
54Congenital primary aphakia (HP:0007707)2.11692943
55Aplasia/Hypoplasia of the tongue (HP:0010295)2.10202002
56Cerebellar dysplasia (HP:0007033)2.09576063
57Polyuria (HP:0000103)2.08832687
58Lissencephaly (HP:0001339)2.07250496
59Aplasia/Hypoplasia of the spleen (HP:0010451)2.05690894
60Methylmalonic acidemia (HP:0002912)2.05535457
61Nephrogenic diabetes insipidus (HP:0009806)2.03084275
62Male pseudohermaphroditism (HP:0000037)2.01520327
63Furrowed tongue (HP:0000221)2.01502571
64Methylmalonic aciduria (HP:0012120)2.00808339
65Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.00804343
66Retinal dysplasia (HP:0007973)2.00062674
67Increased hepatocellular lipid droplets (HP:0006565)1.99596100
68Hepatic necrosis (HP:0002605)1.97260010
69Hypothermia (HP:0002045)1.97046059
70Concave nail (HP:0001598)1.95635910
71Optic nerve hypoplasia (HP:0000609)1.95560435
72Progressive cerebellar ataxia (HP:0002073)1.94289608
73Rib fusion (HP:0000902)1.92240164
74Asplenia (HP:0001746)1.89890394
75Postaxial foot polydactyly (HP:0001830)1.89467380
76Abnormality of the pons (HP:0007361)1.89203261
77Ketosis (HP:0001946)1.88814596
78Broad-based gait (HP:0002136)1.88017883
79Hypoproteinemia (HP:0003075)1.87641830
80Abnormal albumin level (HP:0012116)1.87464790
81Hypoalbuminemia (HP:0003073)1.87464790
82Aplasia/Hypoplasia of the tibia (HP:0005772)1.86238923
83Stomach cancer (HP:0012126)1.86222764
84Decreased circulating renin level (HP:0003351)1.85732056
85Progressive inability to walk (HP:0002505)1.84781835
86Genital tract atresia (HP:0001827)1.84255278
87Gaze-evoked nystagmus (HP:0000640)1.83792756
88Patellar aplasia (HP:0006443)1.83095418
89Hypoplasia of the pons (HP:0012110)1.82765292
90IgG deficiency (HP:0004315)1.82560455
91Aplasia/Hypoplasia of the patella (HP:0006498)1.81395745
92Thyroiditis (HP:0100646)1.79573504
93Protruding tongue (HP:0010808)1.79028099
94Pachygyria (HP:0001302)1.78141985
95Ketoacidosis (HP:0001993)1.78032134
96Abnormal ciliary motility (HP:0012262)1.78006999
97Severe muscular hypotonia (HP:0006829)1.77737575
98Vaginal atresia (HP:0000148)1.77376358
99Focal motor seizures (HP:0011153)1.77064251
100Chorioretinal atrophy (HP:0000533)1.76688359

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.45023900
2BMPR1B3.47166611
3ADRBK23.32877650
4TXK2.95923664
5ZAK2.95714691
6WNK42.61519931
7MAP4K22.59033091
8PINK12.51871757
9GRK12.50352575
10TLK12.32816219
11WNK32.26921819
12TAOK32.26263245
13CASK2.05567650
14ACVR1B1.93486997
15INSRR1.91191923
16MAPK131.82752823
17NUAK11.73671930
18BCKDK1.73064394
19DAPK21.72701225
20MUSK1.54489325
21MAP3K41.50675776
22CAMKK21.46277756
23OXSR11.30618681
24STK391.28251749
25DYRK21.21481191
26TNIK1.20020976
27ADRBK11.17090048
28TIE11.16414036
29STK161.09434283
30VRK11.08190645
31PAK31.02756936
32MARK10.98724707
33MAPK150.97256354
34MAP2K70.95786588
35KDR0.94278749
36MAP2K60.88225278
37TGFBR10.88219371
38PRKCG0.88209347
39PIK3CA0.88089310
40PRKCE0.86338719
41ITK0.84891272
42PLK20.84730160
43TRIM280.83540226
44MAPKAPK30.82503077
45PRKCQ0.80609176
46EPHA40.79425107
47GRK70.79078210
48TEC0.78380125
49CSNK1G20.78165546
50NTRK30.78071831
51PHKG20.75650628
52PHKG10.75650628
53CSNK1G10.75213027
54KIT0.74569151
55AKT30.74463782
56PNCK0.71942249
57CSNK1G30.69201155
58CAMK2A0.67378483
59VRK20.66415450
60MST40.66121635
61OBSCN0.65512727
62MKNK20.65165498
63IKBKB0.63336983
64RPS6KA50.60785339
65NME10.59923150
66FGFR20.57840741
67PRKACA0.57413249
68NTRK20.57075418
69PTK2B0.56352934
70CAMK10.55273103
71PKN10.54502260
72TAF10.51286616
73SYK0.50482179
74CSNK1A1L0.49622394
75TNK20.49449371
76BRSK20.48215481
77CSNK1A10.46655207
78NLK0.46654234
79STK38L0.45521596
80PRKCA0.45183029
81MAPKAPK50.44867126
82PRKCI0.44674792
83CAMKK10.44639541
84ERBB30.44549235
85PLK30.43833246
86LCK0.38006802
87IRAK40.37975967
88EPHA30.36017472
89STK110.35633387
90BCR0.35631016
91PLK40.35600656
92FLT30.35353219
93PRKCZ0.35135317
94WEE10.33658350
95IRAK10.33057178
96IGF1R0.32285491
97GRK50.31994811
98CSNK1D0.30035699
99LYN0.30004005
100PRKCH0.29862211

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.05011080
2Oxidative phosphorylation_Homo sapiens_hsa001902.84972038
3Linoleic acid metabolism_Homo sapiens_hsa005912.80078104
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.73265677
5Nitrogen metabolism_Homo sapiens_hsa009102.30827297
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.28657904
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.24170073
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.19863469
9Parkinsons disease_Homo sapiens_hsa050122.14970727
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.14460035
11Butanoate metabolism_Homo sapiens_hsa006502.07491891
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.04828475
13Protein export_Homo sapiens_hsa030602.00728273
14Selenocompound metabolism_Homo sapiens_hsa004501.92998463
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.90729421
16Nicotine addiction_Homo sapiens_hsa050331.90619977
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.90610217
18Ether lipid metabolism_Homo sapiens_hsa005651.87641152
19Primary immunodeficiency_Homo sapiens_hsa053401.86146967
20Caffeine metabolism_Homo sapiens_hsa002321.85133131
21RNA polymerase_Homo sapiens_hsa030201.80135778
22Tryptophan metabolism_Homo sapiens_hsa003801.70534610
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.64049875
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.62474031
25Homologous recombination_Homo sapiens_hsa034401.53083866
26Alzheimers disease_Homo sapiens_hsa050101.39679282
27Cardiac muscle contraction_Homo sapiens_hsa042601.37418086
28Huntingtons disease_Homo sapiens_hsa050161.35617984
29Sulfur relay system_Homo sapiens_hsa041221.33148282
30Proteasome_Homo sapiens_hsa030501.30598542
31Taste transduction_Homo sapiens_hsa047421.26092407
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21844004
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.21761261
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.20868191
35Fanconi anemia pathway_Homo sapiens_hsa034601.20671405
36Olfactory transduction_Homo sapiens_hsa047401.15682434
37Basal transcription factors_Homo sapiens_hsa030221.15195148
38Peroxisome_Homo sapiens_hsa041461.13213767
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11391576
40Propanoate metabolism_Homo sapiens_hsa006401.09594312
41One carbon pool by folate_Homo sapiens_hsa006701.08800503
42Arachidonic acid metabolism_Homo sapiens_hsa005901.07411870
43Morphine addiction_Homo sapiens_hsa050321.07335550
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06497526
45RNA degradation_Homo sapiens_hsa030181.05931108
46Ribosome_Homo sapiens_hsa030101.05103536
47Chemical carcinogenesis_Homo sapiens_hsa052041.03182935
48Retinol metabolism_Homo sapiens_hsa008301.01665904
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00477279
50Primary bile acid biosynthesis_Homo sapiens_hsa001200.98778944
51Type I diabetes mellitus_Homo sapiens_hsa049400.96717093
52Graft-versus-host disease_Homo sapiens_hsa053320.95297710
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.94685011
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91290475
55Autoimmune thyroid disease_Homo sapiens_hsa053200.86160913
56ABC transporters_Homo sapiens_hsa020100.84592273
57Insulin secretion_Homo sapiens_hsa049110.83895927
58Collecting duct acid secretion_Homo sapiens_hsa049660.82991793
59Regulation of autophagy_Homo sapiens_hsa041400.81585968
60Serotonergic synapse_Homo sapiens_hsa047260.80346858
61GABAergic synapse_Homo sapiens_hsa047270.79778386
62Asthma_Homo sapiens_hsa053100.78668069
63Allograft rejection_Homo sapiens_hsa053300.77979765
64Glutamatergic synapse_Homo sapiens_hsa047240.77356747
65Circadian entrainment_Homo sapiens_hsa047130.74784290
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73517848
67Vitamin digestion and absorption_Homo sapiens_hsa049770.73022140
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70517105
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66884525
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66801428
71Fat digestion and absorption_Homo sapiens_hsa049750.66444960
72Purine metabolism_Homo sapiens_hsa002300.65126087
73Rheumatoid arthritis_Homo sapiens_hsa053230.65112898
74Sulfur metabolism_Homo sapiens_hsa009200.63874617
75Ovarian steroidogenesis_Homo sapiens_hsa049130.62121905
76Metabolic pathways_Homo sapiens_hsa011000.59310101
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58612722
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58196009
79Antigen processing and presentation_Homo sapiens_hsa046120.57256036
80beta-Alanine metabolism_Homo sapiens_hsa004100.57148788
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56664353
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55899778
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55154346
84Calcium signaling pathway_Homo sapiens_hsa040200.54971489
85Salivary secretion_Homo sapiens_hsa049700.54719740
86Pyrimidine metabolism_Homo sapiens_hsa002400.53155526
87Glycerolipid metabolism_Homo sapiens_hsa005610.52961515
88Mineral absorption_Homo sapiens_hsa049780.48581541
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.48346008
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48100200
91Hematopoietic cell lineage_Homo sapiens_hsa046400.47823580
92Histidine metabolism_Homo sapiens_hsa003400.42044819
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37564679
94Dopaminergic synapse_Homo sapiens_hsa047280.37295542
95Fatty acid degradation_Homo sapiens_hsa000710.36315476
96Amphetamine addiction_Homo sapiens_hsa050310.33498752
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.33487499
98Steroid biosynthesis_Homo sapiens_hsa001000.31865506
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.29976524
100Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.29086149

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