ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.02037690
2	tryptophan catabolic process (GO:0006569)	4.54581000
3	indole-containing compound catabolic process (GO:0042436)	4.54581000
4	indolalkylamine catabolic process (GO:0046218)	4.54581000
5	indolalkylamine metabolic process (GO:0006586)	4.50121510
6	negative regulation of cytosolic calcium ion concentration (GO:0051481)	4.32061943
7	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.15909856
8	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.04570731
9	tryptophan metabolic process (GO:0006568)	3.98148071
10	cilium or flagellum-dependent cell motility (GO:0001539)	3.95688583
11	piRNA metabolic process (GO:0034587)	3.88704555
12	kynurenine metabolic process (GO:0070189)	3.75279310
13	neural tube formation (GO:0001841)	3.71520887
14	photoreceptor cell maintenance (GO:0045494)	3.70271076
15	detection of light stimulus involved in visual perception (GO:0050908)	3.68307870
16	detection of light stimulus involved in sensory perception (GO:0050962)	3.68307870
17	L-fucose catabolic process (GO:0042355)	3.66329808
18	fucose catabolic process (GO:0019317)	3.66329808
19	L-fucose metabolic process (GO:0042354)	3.66329808
20	gamma-aminobutyric acid transport (GO:0015812)	3.60745745
21	neuronal action potential (GO:0019228)	3.56580575
22	indole-containing compound metabolic process (GO:0042430)	3.43294939
23	kidney morphogenesis (GO:0060993)	3.39679045
24	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.37119181
25	platelet dense granule organization (GO:0060155)	3.35404600
26	adenosine metabolic process (GO:0046085)	3.26613786
27	axoneme assembly (GO:0035082)	3.23236444
28	spinal cord motor neuron differentiation (GO:0021522)	3.17226407
29	nonmotile primary cilium assembly (GO:0035058)	3.16354077
30	regulation of cytokine production involved in inflammatory response (GO:1900015)	3.15341103
31	reflex (GO:0060004)	3.11177380
32	epithelial cilium movement (GO:0003351)	3.08893694
33	response to pheromone (GO:0019236)	3.07860622
34	DNA methylation involved in gamete generation (GO:0043046)	2.98597514
35	cellular ketone body metabolic process (GO:0046950)	2.95619154
36	respiratory chain complex IV assembly (GO:0008535)	2.93910914
37	behavioral response to ethanol (GO:0048149)	2.91909742
38	protein localization to cilium (GO:0061512)	2.89886856
39	cilium movement (GO:0003341)	2.86776357
40	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.84972388
41	membrane depolarization during action potential (GO:0086010)	2.83544468
42	amine catabolic process (GO:0009310)	2.83361228
43	cellular biogenic amine catabolic process (GO:0042402)	2.83361228
44	sulfation (GO:0051923)	2.83347643
45	protein K11-linked deubiquitination (GO:0035871)	2.80197134
46	multicellular organism reproduction (GO:0032504)	2.76276017
47	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.74523943
48	retinal cone cell development (GO:0046549)	2.73440244
49	histone H3-K9 methylation (GO:0051567)	2.73361864
50	calcium ion import (GO:0070509)	2.70335894
51	cilium organization (GO:0044782)	2.69453906
52	negative regulation of systemic arterial blood pressure (GO:0003085)	2.68950436
53	somite development (GO:0061053)	2.67938868
54	photoreceptor cell development (GO:0042461)	2.66833872
55	dendritic spine morphogenesis (GO:0060997)	2.66095447
56	synaptic transmission, cholinergic (GO:0007271)	2.66020864
57	adaptation of signaling pathway (GO:0023058)	2.65488257
58	limb bud formation (GO:0060174)	2.63222755
59	ketone body metabolic process (GO:1902224)	2.61973198
60	cilium assembly (GO:0042384)	2.61879881
61	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.61189634
62	cell differentiation in spinal cord (GO:0021515)	2.60514730
63	action potential (GO:0001508)	2.58578468
64	cilium morphogenesis (GO:0060271)	2.57099264
65	regulation of hippo signaling (GO:0035330)	2.57048185
66	pyrimidine nucleobase catabolic process (GO:0006208)	2.56941035
67	regulation of translation, ncRNA-mediated (GO:0045974)	2.56915231
68	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.56915231
69	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.56915231
70	fatty acid transmembrane transport (GO:1902001)	2.56258938
71	oxidative demethylation (GO:0070989)	2.53893545
72	protein localization to synapse (GO:0035418)	2.52686328
73	response to caffeine (GO:0031000)	2.50788743
74	tachykinin receptor signaling pathway (GO:0007217)	2.49240518
75	vascular smooth muscle contraction (GO:0014829)	2.48981663
76	regulation of action potential (GO:0098900)	2.48647833
77	interkinetic nuclear migration (GO:0022027)	2.48352274
78	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.47804371
79	opioid receptor signaling pathway (GO:0038003)	2.47788699
80	monoubiquitinated protein deubiquitination (GO:0035520)	2.47555741
81	inner ear receptor stereocilium organization (GO:0060122)	2.44708344
82	microtubule anchoring (GO:0034453)	2.44482491
83	thyroid hormone metabolic process (GO:0042403)	2.44208890
84	regulation of gene silencing by miRNA (GO:0060964)	2.44134192
85	regulation of gene silencing by RNA (GO:0060966)	2.44134192
86	regulation of posttranscriptional gene silencing (GO:0060147)	2.44134192
87	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.44121252
88	primary amino compound metabolic process (GO:1901160)	2.43834149
89	protein polyglutamylation (GO:0018095)	2.43233025
90	gonadal mesoderm development (GO:0007506)	2.39621563
91	cytochrome complex assembly (GO:0017004)	2.39373768
92	inositol phosphate catabolic process (GO:0071545)	2.38966409
93	ncRNA catabolic process (GO:0034661)	2.38725492
94	cornea development in camera-type eye (GO:0061303)	2.38246936
95	prenylation (GO:0097354)	2.36875685
96	protein prenylation (GO:0018342)	2.36875685
97	serotonin metabolic process (GO:0042428)	2.36798736
98	regulation of cilium movement (GO:0003352)	2.36795222
99	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.36632303
100	regulation of timing of cell differentiation (GO:0048505)	2.36302610

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.54267271
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.47781799
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.30958618
4	VDR_22108803_ChIP-Seq_LS180_Human	3.30667810
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.91548776
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.67901239
7	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.67840689
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.52844782
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.47031474
10	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.38633470
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.28001778
12	FUS_26573619_Chip-Seq_HEK293_Human	2.21472459
13	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.21142146
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.20720349
15	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.08447141
16	P300_19829295_ChIP-Seq_ESCs_Human	2.05072453
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.98556655
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.94147388
19	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.93251176
20	EWS_26573619_Chip-Seq_HEK293_Human	1.91939416
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.81613980
22	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.81574800
23	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.79011377
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.78212128
25	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.72605955
26	STAT3_23295773_ChIP-Seq_U87_Human	1.71748699
27	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.71415091
28	BCAT_22108803_ChIP-Seq_LS180_Human	1.67116646
29	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.66535786
30	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.66535786
31	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.64381556
32	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.58904964
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.58789668
34	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.58123993
35	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.57766888
36	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.56256768
37	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.53682264
38	TCF4_23295773_ChIP-Seq_U87_Human	1.50665208
39	AR_21572438_ChIP-Seq_LNCaP_Human	1.46479948
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.43078075
41	CBP_20019798_ChIP-Seq_JUKART_Human	1.43078075
42	REST_21632747_ChIP-Seq_MESCs_Mouse	1.42485066
43	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.40596842
44	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.39928090
45	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.38708789
46	TP53_22573176_ChIP-Seq_HFKS_Human	1.37287603
47	AR_25329375_ChIP-Seq_VCAP_Human	1.37018371
48	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.35209518
49	RUNX2_22187159_ChIP-Seq_PCA_Human	1.31918676
50	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.29354409
51	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.28983451
52	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.26567067
53	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.26279958
54	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.26204237
55	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24458211
56	RNF2_27304074_Chip-Seq_NSC_Mouse	1.24240659
57	TP53_16413492_ChIP-PET_HCT116_Human	1.22519251
58	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.21894442
59	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.19937600
60	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.19484013
61	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.18739598
62	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.18675155
63	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.17756816
64	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.17438650
65	RXR_22108803_ChIP-Seq_LS180_Human	1.16028273
66	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.15569470
67	NANOG_19829295_ChIP-Seq_ESCs_Human	1.15438812
68	SOX2_19829295_ChIP-Seq_ESCs_Human	1.15438812
69	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.14835249
70	TCF4_22108803_ChIP-Seq_LS180_Human	1.13282280
71	IRF1_19129219_ChIP-ChIP_H3396_Human	1.12970891
72	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.12733749
73	DROSHA_22980978_ChIP-Seq_HELA_Human	1.11795845
74	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.09749073
75	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.09515663
76	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.08695536
77	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.07838375
78	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.07283819
79	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06352568
80	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.05760389
81	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.05709756
82	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.04686773
83	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.04686773
84	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.04068521
85	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.02618372
86	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.02443955
87	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.02263859
88	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.02089892
89	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.01915332
90	NCOR_22424771_ChIP-Seq_293T_Human	1.00742266
91	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.00396616
92	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99802617
93	KDM2B_26808549_Chip-Seq_REH_Human	0.98479325
94	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.98250756
95	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.98134122
96	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.97830664
97	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.97439331
98	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.97219202
99	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.95955262
100	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.95684624

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.34265660
2	MP0003136_yellow_coat_color	3.17240002
3	MP0003195_calcinosis	3.03725840
4	MP0000569_abnormal_digit_pigmentation	2.81077119
5	MP0005551_abnormal_eye_electrophysiolog	2.75125478
6	MP0006276_abnormal_autonomic_nervous	2.66742052
7	MP0002102_abnormal_ear_morphology	2.62079576
8	MP0005423_abnormal_somatic_nervous	2.58118942
9	MP0008877_abnormal_DNA_methylation	2.24919474
10	MP0002638_abnormal_pupillary_reflex	2.13293186
11	MP0003646_muscle_fatigue	2.00734992
12	MP0006292_abnormal_olfactory_placode	1.97468947
13	MP0002876_abnormal_thyroid_physiology	1.96149132
14	MP0002735_abnormal_chemical_nociception	1.94170376
15	MP0009745_abnormal_behavioral_response	1.91577164
16	MP0001986_abnormal_taste_sensitivity	1.89546911
17	MP0004133_heterotaxia	1.86581662
18	MP0001968_abnormal_touch/_nociception	1.81842739
19	MP0003183_abnormal_peptide_metabolism	1.78113503
20	MP0004142_abnormal_muscle_tone	1.76576618
21	MP0003890_abnormal_embryonic-extraembry	1.76569169
22	MP0002837_dystrophic_cardiac_calcinosis	1.74988396
23	MP0001501_abnormal_sleep_pattern	1.74901289
24	MP0002736_abnormal_nociception_after	1.73371879
25	MP0001485_abnormal_pinna_reflex	1.71655216
26	MP0008872_abnormal_physiological_respon	1.71573232
27	MP0002653_abnormal_ependyma_morphology	1.67157804
28	MP0000631_abnormal_neuroendocrine_gland	1.66005655
29	MP0005645_abnormal_hypothalamus_physiol	1.63033513
30	MP0009046_muscle_twitch	1.62308588
31	MP0001486_abnormal_startle_reflex	1.56992461
32	MP0003787_abnormal_imprinting	1.54250504
33	MP0005253_abnormal_eye_physiology	1.51146007
34	MP0002272_abnormal_nervous_system	1.47868190
35	MP0000427_abnormal_hair_cycle	1.44599096
36	MP0006072_abnormal_retinal_apoptosis	1.41069108
37	MP0005646_abnormal_pituitary_gland	1.40469724
38	MP0005174_abnormal_tail_pigmentation	1.39070855
39	MP0003011_delayed_dark_adaptation	1.36299666
40	MP0002572_abnormal_emotion/affect_behav	1.36179554
41	MP0002064_seizures	1.34790459
42	MP0004147_increased_porphyrin_level	1.34548323
43	MP0003950_abnormal_plasma_membrane	1.33203729
44	MP0001984_abnormal_olfaction	1.31415850
45	MP0002138_abnormal_hepatobiliary_system	1.31379629
46	MP0000778_abnormal_nervous_system	1.29293248
47	MP0002734_abnormal_mechanical_nocicepti	1.25796059
48	MP0002938_white_spotting	1.25554126
49	MP0005377_hearing/vestibular/ear_phenot	1.25368521
50	MP0003878_abnormal_ear_physiology	1.25368521
51	MP0004043_abnormal_pH_regulation	1.24781234
52	MP0004130_abnormal_muscle_cell	1.24740301
53	MP0003635_abnormal_synaptic_transmissio	1.24256283
54	MP0001970_abnormal_pain_threshold	1.23827095
55	MP0002067_abnormal_sensory_capabilities	1.23631003
56	MP0004145_abnormal_muscle_electrophysio	1.23055177
57	MP0010386_abnormal_urinary_bladder	1.22841973
58	MP0002928_abnormal_bile_duct	1.22220314
59	MP0002557_abnormal_social/conspecific_i	1.21249982
60	MP0000383_abnormal_hair_follicle	1.18811741
61	MP0005195_abnormal_posterior_eye	1.11932886
62	MP0000372_irregular_coat_pigmentation	1.11126184
63	MP0002063_abnormal_learning/memory/cond	1.10637668
64	MP0004924_abnormal_behavior	1.07388122
65	MP0005386_behavior/neurological_phenoty	1.07388122
66	MP0004885_abnormal_endolymph	1.06518210
67	MP0002234_abnormal_pharynx_morphology	1.02439610
68	MP0004742_abnormal_vestibular_system	0.99724145
69	MP0002752_abnormal_somatic_nervous	0.98337833
70	MP0001529_abnormal_vocalization	0.97476885
71	MP0004084_abnormal_cardiac_muscle	0.96536167
72	MP0002229_neurodegeneration	0.94852144
73	MP0005083_abnormal_biliary_tract	0.93785033
74	MP0004215_abnormal_myocardial_fiber	0.93228235
75	MP0000015_abnormal_ear_pigmentation	0.91542084
76	MP0005266_abnormal_metabolism	0.91372725
77	MP0008875_abnormal_xenobiotic_pharmacok	0.90758002
78	MP0002095_abnormal_skin_pigmentation	0.88786134
79	MP0001324_abnormal_eye_pigmentation	0.88424684
80	MP0002733_abnormal_thermal_nociception	0.87299061
81	MP0004085_abnormal_heartbeat	0.86565785
82	MP0000026_abnormal_inner_ear	0.86495984
83	MP0003283_abnormal_digestive_organ	0.86098140
84	MP0003698_abnormal_male_reproductive	0.85223826
85	MP0001963_abnormal_hearing_physiology	0.83393803
86	MP0002751_abnormal_autonomic_nervous	0.83085410
87	MP0008995_early_reproductive_senescence	0.82701417
88	MP0008775_abnormal_heart_ventricle	0.81994548
89	MP0005448_abnormal_energy_balance	0.81366812
90	MP0005410_abnormal_fertilization	0.80903694
91	MP0000230_abnormal_systemic_arterial	0.78759246
92	MP0008961_abnormal_basal_metabolism	0.77306308
93	MP0003119_abnormal_digestive_system	0.76250609
94	MP0002882_abnormal_neuron_morphology	0.75219700
95	MP0000955_abnormal_spinal_cord	0.74737472
96	MP0003137_abnormal_impulse_conducting	0.71880662
97	MP0001502_abnormal_circadian_rhythm	0.71242264
98	MP0000538_abnormal_urinary_bladder	0.69452123
99	MP0001440_abnormal_grooming_behavior	0.69138962
100	MP0001929_abnormal_gametogenesis	0.69053469

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.57990288
2	Molar tooth sign on MRI (HP:0002419)	4.51598450
3	Abnormality of midbrain morphology (HP:0002418)	4.51598450
4	Pancreatic fibrosis (HP:0100732)	4.05451793
5	True hermaphroditism (HP:0010459)	3.93789255
6	Congenital stationary night blindness (HP:0007642)	3.74385890
7	Attenuation of retinal blood vessels (HP:0007843)	3.46257120
8	Nephronophthisis (HP:0000090)	3.40196784
9	Abnormality of the renal cortex (HP:0011035)	3.31410523
10	Protruding tongue (HP:0010808)	3.24322145
11	Abnormality of the renal medulla (HP:0100957)	3.22593839
12	Hyperventilation (HP:0002883)	3.17936463
13	Type II lissencephaly (HP:0007260)	3.06352334
14	Chronic hepatic failure (HP:0100626)	3.00236618
15	Small hand (HP:0200055)	2.99164344
16	Abolished electroretinogram (ERG) (HP:0000550)	2.94556143
17	Cystic liver disease (HP:0006706)	2.93340441
18	Genetic anticipation (HP:0003743)	2.92738275
19	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.91327137
20	Broad-based gait (HP:0002136)	2.84378623
21	Abnormal drinking behavior (HP:0030082)	2.79443171
22	Polydipsia (HP:0001959)	2.79443171
23	Congenital sensorineural hearing impairment (HP:0008527)	2.73663175
24	Absent/shortened dynein arms (HP:0200106)	2.68119244
25	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.68119244
26	Inability to walk (HP:0002540)	2.67645362
27	Medial flaring of the eyebrow (HP:0010747)	2.67604835
28	Hip dysplasia (HP:0001385)	2.66262466
29	Tubular atrophy (HP:0000092)	2.64476311
30	Progressive cerebellar ataxia (HP:0002073)	2.62918083
31	Large for gestational age (HP:0001520)	2.62590065
32	Gaze-evoked nystagmus (HP:0000640)	2.54537198
33	Febrile seizures (HP:0002373)	2.53007426
34	Anencephaly (HP:0002323)	2.50271647
35	Cerebellar dysplasia (HP:0007033)	2.49941283
36	Bony spicule pigmentary retinopathy (HP:0007737)	2.47534644
37	Retinal dysplasia (HP:0007973)	2.46381070
38	Sclerocornea (HP:0000647)	2.42697725
39	Abnormal rod and cone electroretinograms (HP:0008323)	2.42054092
40	Progressive inability to walk (HP:0002505)	2.41455345
41	Hip contracture (HP:0003273)	2.34951834
42	Abnormal ciliary motility (HP:0012262)	2.33408841
43	Polyuria (HP:0000103)	2.32175031
44	Supernumerary spleens (HP:0009799)	2.31308616
45	Optic nerve hypoplasia (HP:0000609)	2.29447797
46	Increased corneal curvature (HP:0100692)	2.28016400
47	Keratoconus (HP:0000563)	2.28016400
48	Disproportionate short-trunk short stature (HP:0003521)	2.27751386
49	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.27505078
50	Short tibia (HP:0005736)	2.27111355
51	Decreased circulating renin level (HP:0003351)	2.24627009
52	Congenital hepatic fibrosis (HP:0002612)	2.24330818
53	Abnormal respiratory epithelium morphology (HP:0012253)	2.18374881
54	Abnormal respiratory motile cilium morphology (HP:0005938)	2.18374881
55	Renal cortical cysts (HP:0000803)	2.18172951
56	Pendular nystagmus (HP:0012043)	2.15835277
57	Abnormality of macular pigmentation (HP:0008002)	2.14353119
58	Gait imbalance (HP:0002141)	2.10970561
59	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.10870855
60	Furrowed tongue (HP:0000221)	2.10867291
61	Lissencephaly (HP:0001339)	2.10301949
62	Hypoplasia of the pons (HP:0012110)	2.09689642
63	Abnormality of the pons (HP:0007361)	2.09163632
64	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.08888384
65	Abnormality of alanine metabolism (HP:0010916)	2.08888384
66	Hyperalaninemia (HP:0003348)	2.08888384
67	Decreased central vision (HP:0007663)	2.06353935
68	Congenital, generalized hypertrichosis (HP:0004540)	2.04567980
69	Methylmalonic acidemia (HP:0002912)	2.01764295
70	Congenital primary aphakia (HP:0007707)	1.99552369
71	Hemiparesis (HP:0001269)	1.94159022
72	Male pseudohermaphroditism (HP:0000037)	1.93712898
73	Chorioretinal atrophy (HP:0000533)	1.92679307
74	Genital tract atresia (HP:0001827)	1.92594423
75	Clumsiness (HP:0002312)	1.89933046
76	Fetal akinesia sequence (HP:0001989)	1.88360124
77	Concave nail (HP:0001598)	1.88338692
78	Absent speech (HP:0001344)	1.87745079
79	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.87482230
80	Focal seizures (HP:0007359)	1.87462421
81	Fair hair (HP:0002286)	1.87376031
82	Constricted visual fields (HP:0001133)	1.87018972
83	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.86256411
84	Postaxial hand polydactyly (HP:0001162)	1.86150213
85	Postaxial foot polydactyly (HP:0001830)	1.85978151
86	Stomach cancer (HP:0012126)	1.83407241
87	Vaginal atresia (HP:0000148)	1.80601960
88	Bile duct proliferation (HP:0001408)	1.79754566
89	Abnormal biliary tract physiology (HP:0012439)	1.79754566
90	Nephrogenic diabetes insipidus (HP:0009806)	1.79663615
91	Abnormal respiratory motile cilium physiology (HP:0012261)	1.78559483
92	Abnormal urine output (HP:0012590)	1.77897912
93	Methylmalonic aciduria (HP:0012120)	1.76794614
94	Hypothermia (HP:0002045)	1.76042327
95	Preaxial hand polydactyly (HP:0001177)	1.75546440
96	Carpal bone hypoplasia (HP:0001498)	1.74738084
97	Aplasia of the musculature (HP:0100854)	1.74557622
98	Focal motor seizures (HP:0011153)	1.73550563
99	Facial hemangioma (HP:0000329)	1.72689973
100	Rib fusion (HP:0000902)	1.70996470

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	INSRR	6.14159972
2	FRK	4.79976326
3	LATS1	4.46670401
4	NUAK1	3.60865895
5	BMPR1B	2.56231562
6	ADRBK2	2.49891236
7	WNK3	2.44728799
8	ACVR1B	2.20254680
9	MAP3K4	2.00730292
10	MARK1	1.87011909
11	TLK1	1.72931568
12	ZAK	1.67979540
13	CASK	1.66807882
14	OXSR1	1.64596811
15	PINK1	1.57643998
16	MAP4K2	1.56464779
17	MAPK13	1.55747894
18	TNIK	1.55465559
19	GRK1	1.51799362
20	STK3	1.51017091
21	STK39	1.48912435
22	WNK4	1.48845301
23	DAPK2	1.34952165
24	TAOK3	1.27238466
25	MAP2K7	1.26389744
26	EPHA3	1.25920458
27	MKNK2	1.17286721
28	MAPK15	1.13415470
29	PNCK	1.10783169
30	MAP3K7	1.06173811
31	EIF2AK3	1.04555044
32	ADRBK1	1.02378475
33	AKT3	0.96653384
34	TGFBR1	0.94550517
35	MUSK	0.94230551
36	TXK	0.92541827
37	OBSCN	0.88861725
38	CAMKK2	0.88349469
39	PAK3	0.88256762
40	NTRK3	0.87572838
41	PRKCE	0.86435712
42	IRAK1	0.85888784
43	DYRK2	0.85097832
44	PTK2B	0.82410068
45	TEC	0.80599660
46	TIE1	0.80473799
47	NLK	0.75171870
48	PRKCG	0.73852040
49	PIK3CA	0.69789085
50	SGK2	0.69292891
51	NME1	0.68028863
52	FER	0.65976505
53	SIK2	0.63807041
54	STK38L	0.62907561
55	STK11	0.62633668
56	TNK2	0.61629214
57	CHEK2	0.56504161
58	BRSK2	0.56429095
59	KIT	0.56240714
60	PRKAA1	0.55244478
61	CAMK2A	0.52713445
62	PRKAA2	0.52325670
63	FGFR2	0.51422491
64	PHKG1	0.50862849
65	PHKG2	0.50862849
66	NTRK2	0.49557783
67	VRK1	0.48291221
68	CAMK1	0.47707073
69	MAP2K4	0.46956590
70	SGK223	0.46748728
71	SGK494	0.46748728
72	RPS6KA6	0.46441853
73	PKN1	0.46156736
74	MKNK1	0.45969905
75	PRKACA	0.45584863
76	CSNK1G2	0.45040820
77	EPHA4	0.45003914
78	PLK4	0.42405232
79	RPS6KA5	0.41557811
80	PLK2	0.39453501
81	PRKG1	0.38675870
82	BRD4	0.38657268
83	TYRO3	0.37765756
84	PIK3CG	0.36750905
85	MAP2K1	0.35932891
86	MAPKAPK3	0.35335997
87	DYRK1A	0.35176528
88	ITK	0.35128813
89	CAMK4	0.34227815
90	CSNK1G1	0.33471219
91	PRKCQ	0.32920310
92	CHUK	0.30650396
93	GRK7	0.30338278
94	PRKCA	0.29139317
95	NEK2	0.28103433
96	CSNK1D	0.27914340
97	SGK1	0.27867018
98	TRIM28	0.27534628
99	MAP2K6	0.27098899
100	FES	0.27057952

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.33885834
2	Linoleic acid metabolism_Homo sapiens_hsa00591	3.00181806
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.84690920
4	Phototransduction_Homo sapiens_hsa04744	2.69255635
5	Nicotine addiction_Homo sapiens_hsa05033	2.58137563
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.44736162
7	Tryptophan metabolism_Homo sapiens_hsa00380	2.43429255
8	Butanoate metabolism_Homo sapiens_hsa00650	2.43187201
9	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.16015832
10	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.04904583
11	Taste transduction_Homo sapiens_hsa04742	2.03245587
12	Ether lipid metabolism_Homo sapiens_hsa00565	1.88874701
13	ABC transporters_Homo sapiens_hsa02010	1.87353178
14	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.84533767
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.79256848
16	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.79031323
17	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.78146834
18	Olfactory transduction_Homo sapiens_hsa04740	1.77780981
19	Caffeine metabolism_Homo sapiens_hsa00232	1.74853674
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.57871169
21	RNA polymerase_Homo sapiens_hsa03020	1.54945859
22	Morphine addiction_Homo sapiens_hsa05032	1.47119590
23	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.46815978
24	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.42428725
25	Selenocompound metabolism_Homo sapiens_hsa00450	1.41369991
26	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.39508821
27	Circadian rhythm_Homo sapiens_hsa04710	1.39173392
28	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.35285599
29	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.34331232
30	Regulation of autophagy_Homo sapiens_hsa04140	1.26451618
31	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.25929869
32	Serotonergic synapse_Homo sapiens_hsa04726	1.24170590
33	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.23666883
34	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.22372100
35	Cardiac muscle contraction_Homo sapiens_hsa04260	1.20632091
36	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.18195942
37	Glutamatergic synapse_Homo sapiens_hsa04724	1.17260798
38	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.15556037
39	Propanoate metabolism_Homo sapiens_hsa00640	1.15336956
40	Basal transcription factors_Homo sapiens_hsa03022	1.15154804
41	Insulin secretion_Homo sapiens_hsa04911	1.15116352
42	GABAergic synapse_Homo sapiens_hsa04727	1.13790826
43	Chemical carcinogenesis_Homo sapiens_hsa05204	1.13404286
44	Circadian entrainment_Homo sapiens_hsa04713	1.11755092
45	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.10922021
46	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.07159322
47	Calcium signaling pathway_Homo sapiens_hsa04020	1.03374905
48	Retinol metabolism_Homo sapiens_hsa00830	1.02794635
49	Histidine metabolism_Homo sapiens_hsa00340	1.01724561
50	Salivary secretion_Homo sapiens_hsa04970	0.93598770
51	beta-Alanine metabolism_Homo sapiens_hsa00410	0.92527744
52	Homologous recombination_Homo sapiens_hsa03440	0.91878965
53	Fanconi anemia pathway_Homo sapiens_hsa03460	0.89145020
54	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.87798963
55	Oxidative phosphorylation_Homo sapiens_hsa00190	0.87649088
56	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.82280958
57	Mineral absorption_Homo sapiens_hsa04978	0.80772563
58	Fat digestion and absorption_Homo sapiens_hsa04975	0.80472928
59	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.78881680
60	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.76864120
61	Glycerolipid metabolism_Homo sapiens_hsa00561	0.74769723
62	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.74195548
63	Protein export_Homo sapiens_hsa03060	0.72798110
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.70779167
65	Peroxisome_Homo sapiens_hsa04146	0.70506312
66	Lysine degradation_Homo sapiens_hsa00310	0.65194464
67	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.64940150
68	Cocaine addiction_Homo sapiens_hsa05030	0.63993684
69	cAMP signaling pathway_Homo sapiens_hsa04024	0.63303936
70	RNA degradation_Homo sapiens_hsa03018	0.62116726
71	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.57956623
72	Cholinergic synapse_Homo sapiens_hsa04725	0.57314633
73	Collecting duct acid secretion_Homo sapiens_hsa04966	0.50827996
74	Dopaminergic synapse_Homo sapiens_hsa04728	0.49079583
75	Huntingtons disease_Homo sapiens_hsa05016	0.47611841
76	Gastric acid secretion_Homo sapiens_hsa04971	0.46863761
77	Parkinsons disease_Homo sapiens_hsa05012	0.46698191
78	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.46590156
79	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.46517298
80	Purine metabolism_Homo sapiens_hsa00230	0.46443769
81	Long-term depression_Homo sapiens_hsa04730	0.46439329
82	Pancreatic secretion_Homo sapiens_hsa04972	0.43243573
83	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.42739738
84	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.42007308
85	Basal cell carcinoma_Homo sapiens_hsa05217	0.41796022
86	Fatty acid degradation_Homo sapiens_hsa00071	0.41156518
87	Renin secretion_Homo sapiens_hsa04924	0.41016057
88	Amphetamine addiction_Homo sapiens_hsa05031	0.39947476
89	Asthma_Homo sapiens_hsa05310	0.39940083
90	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.39664101
91	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.37056352
92	Metabolic pathways_Homo sapiens_hsa01100	0.36288500
93	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.33157971
94	Bile secretion_Homo sapiens_hsa04976	0.32309101
95	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.31501045
96	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.29716591
97	Axon guidance_Homo sapiens_hsa04360	0.28367163
98	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.27230015
99	Ribosome_Homo sapiens_hsa03010	0.26762297
100	Alzheimers disease_Homo sapiens_hsa05010	0.26066809

ZNF844

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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