ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	4.63689586
2	platelet dense granule organization (GO:0060155)	4.41195645
3	respiratory chain complex IV assembly (GO:0008535)	4.12290461
4	water-soluble vitamin biosynthetic process (GO:0042364)	3.89072891
5	L-fucose catabolic process (GO:0042355)	3.82388028
6	fucose catabolic process (GO:0019317)	3.82388028
7	L-fucose metabolic process (GO:0042354)	3.82388028
8	cytochrome complex assembly (GO:0017004)	3.81847984
9	protein complex biogenesis (GO:0070271)	3.76900148
10	DNA double-strand break processing (GO:0000729)	3.56154244
11	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.54809215
12	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.54809215
13	NADH dehydrogenase complex assembly (GO:0010257)	3.54809215
14	protein prenylation (GO:0018342)	3.48032227
15	prenylation (GO:0097354)	3.48032227
16	mitochondrial respiratory chain complex assembly (GO:0033108)	3.47277496
17	protein neddylation (GO:0045116)	3.47275268
18	regulation of cilium movement (GO:0003352)	3.45103041
19	response to pheromone (GO:0019236)	3.37869173
20	axoneme assembly (GO:0035082)	3.31643732
21	preassembly of GPI anchor in ER membrane (GO:0016254)	3.23341204
22	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.18085770
23	indolalkylamine metabolic process (GO:0006586)	3.15426802
24	inositol phosphate catabolic process (GO:0071545)	3.11235946
25	ubiquinone biosynthetic process (GO:0006744)	3.09257551
26	cellular ketone body metabolic process (GO:0046950)	3.05046398
27	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.04697411
28	epithelial cilium movement (GO:0003351)	3.01725005
29	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.01501620
30	protein deneddylation (GO:0000338)	3.00517622
31	protein polyglutamylation (GO:0018095)	3.00245510
32	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.99630759
33	ubiquinone metabolic process (GO:0006743)	2.99521767
34	establishment of protein localization to Golgi (GO:0072600)	2.98272514
35	regulation of hypersensitivity (GO:0002883)	2.96200623
36	cullin deneddylation (GO:0010388)	2.94360280
37	tryptophan metabolic process (GO:0006568)	2.91214948
38	indole-containing compound catabolic process (GO:0042436)	2.88515089
39	indolalkylamine catabolic process (GO:0046218)	2.88515089
40	tryptophan catabolic process (GO:0006569)	2.88515089
41	inositol phosphate dephosphorylation (GO:0046855)	2.87369520
42	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.87369520
43	cilium morphogenesis (GO:0060271)	2.86620917
44	branched-chain amino acid catabolic process (GO:0009083)	2.86176618
45	S-adenosylmethionine metabolic process (GO:0046500)	2.83439946
46	behavioral response to nicotine (GO:0035095)	2.83409464
47	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.82371257
48	piRNA metabolic process (GO:0034587)	2.81503309
49	cell wall macromolecule catabolic process (GO:0016998)	2.80462899
50	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.79439021
51	ketone body metabolic process (GO:1902224)	2.77600680
52	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	2.76035135
53	protein targeting to Golgi (GO:0000042)	2.74603388
54	mannosylation (GO:0097502)	2.74480410
55	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.70849137
56	protein-cofactor linkage (GO:0018065)	2.70719972
57	polyol catabolic process (GO:0046174)	2.70692190
58	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.70670597
59	protein K11-linked deubiquitination (GO:0035871)	2.69301334
60	detection of light stimulus involved in sensory perception (GO:0050962)	2.64975479
61	detection of light stimulus involved in visual perception (GO:0050908)	2.64975479
62	L-methionine salvage (GO:0071267)	2.64945836
63	L-methionine biosynthetic process (GO:0071265)	2.64945836
64	amino acid salvage (GO:0043102)	2.64945836
65	protein localization to Golgi apparatus (GO:0034067)	2.63607400
66	neural tube formation (GO:0001841)	2.62831829
67	kidney morphogenesis (GO:0060993)	2.61420303
68	synapsis (GO:0007129)	2.60250516
69	retinal cone cell development (GO:0046549)	2.59973438
70	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.58654472
71	cilium organization (GO:0044782)	2.56592700
72	regulation of hexokinase activity (GO:1903299)	2.56021561
73	regulation of glucokinase activity (GO:0033131)	2.56021561
74	negative regulation of heart rate (GO:0010459)	2.54375945
75	quinone biosynthetic process (GO:1901663)	2.50225947
76	centriole replication (GO:0007099)	2.50005728
77	negative regulation of mast cell activation (GO:0033004)	2.47542396
78	positive regulation of mast cell degranulation (GO:0043306)	2.47191784
79	positive regulation of mast cell activation involved in immune response (GO:0033008)	2.47191784
80	anterograde synaptic vesicle transport (GO:0048490)	2.46873315
81	intraciliary transport (GO:0042073)	2.46592361
82	cilium movement (GO:0003341)	2.46390565
83	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.46218061
84	regulation of mitotic spindle checkpoint (GO:1903504)	2.46218061
85	nonmotile primary cilium assembly (GO:0035058)	2.46211759
86	cilium assembly (GO:0042384)	2.46034179
87	photoreceptor cell maintenance (GO:0045494)	2.45113666
88	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.43171458
89	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.43171458
90	monoubiquitinated protein deubiquitination (GO:0035520)	2.42985287
91	GPI anchor metabolic process (GO:0006505)	2.40715261
92	regulation of action potential (GO:0098900)	2.39458563
93	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.39230917
94	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.38806964
95	regulation of microtubule-based movement (GO:0060632)	2.37338556
96	dopamine transport (GO:0015872)	2.36674503
97	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.35011498
98	cell wall macromolecule metabolic process (GO:0044036)	2.34986823
99	protein localization to cilium (GO:0061512)	2.34725308
100	amine catabolic process (GO:0009310)	2.34593305

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.87816452
2	VDR_22108803_ChIP-Seq_LS180_Human	3.13487307
3	IGF1R_20145208_ChIP-Seq_DFB_Human	2.97241298
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.76649034
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.71301574
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.54429296
7	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.52319984
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.48381284
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.36328915
10	P300_19829295_ChIP-Seq_ESCs_Human	2.14425920
11	EWS_26573619_Chip-Seq_HEK293_Human	2.11744675
12	FUS_26573619_Chip-Seq_HEK293_Human	2.07815352
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.07672457
14	TAF15_26573619_Chip-Seq_HEK293_Human	2.05350570
15	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.02517817
16	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.02063001
17	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.97154906
18	ER_23166858_ChIP-Seq_MCF-7_Human	1.91706914
19	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.90294184
20	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.84939644
21	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.78580012
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.70467365
23	* CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.70319220
24	BCAT_22108803_ChIP-Seq_LS180_Human	1.69212653
25	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.68020619
26	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.58345274
27	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.56598443
28	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.56543474
29	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.56362499
30	ELK1_19687146_ChIP-ChIP_HELA_Human	1.55459926
31	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.55114728
32	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.54158774
33	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.52636258
34	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.51958144
35	CBP_20019798_ChIP-Seq_JUKART_Human	1.51958144
36	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.50545666
37	TP53_22573176_ChIP-Seq_HFKS_Human	1.49819838
38	SOX2_19829295_ChIP-Seq_ESCs_Human	1.47080974
39	NANOG_19829295_ChIP-Seq_ESCs_Human	1.47080974
40	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.46019595
41	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.45805303
42	* VDR_23849224_ChIP-Seq_CD4+_Human	1.45710943
43	SMAD4_21799915_ChIP-Seq_A2780_Human	1.44742297
44	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.44309627
45	STAT3_23295773_ChIP-Seq_U87_Human	1.44266721
46	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.40691625
47	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.40284368
48	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37554272
49	AR_25329375_ChIP-Seq_VCAP_Human	1.36252951
50	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.35933316
51	* TCF4_23295773_ChIP-Seq_U87_Human	1.33732083
52	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.33694667
53	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.31337777
54	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.29451874
55	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.29153443
56	TCF4_22108803_ChIP-Seq_LS180_Human	1.29057778
57	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.28871705
58	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.28388691
59	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.28316748
60	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.27362469
61	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.27362469
62	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.27136534
63	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.26887036
64	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.25708428
65	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.25247460
66	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.24830277
67	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.24830277
68	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.23540738
69	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.20542637
70	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.19963394
71	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.17868257
72	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.17455883
73	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.17303757
74	P53_22387025_ChIP-Seq_ESCs_Mouse	1.17145787
75	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.17104372
76	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.17051986
77	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.16903150
78	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.15970005
79	* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.15184262
80	GATA3_26560356_Chip-Seq_TH2_Human	1.13554285
81	AR_20517297_ChIP-Seq_VCAP_Human	1.12829890
82	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.12271037
83	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.11186013
84	MYC_18940864_ChIP-ChIP_HL60_Human	1.10325369
85	CDX2_22108803_ChIP-Seq_LS180_Human	1.09381661
86	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.09081749
87	NCOR_22424771_ChIP-Seq_293T_Human	1.08455056
88	RUNX2_22187159_ChIP-Seq_PCA_Human	1.07913134
89	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.07703225
90	IRF1_19129219_ChIP-ChIP_H3396_Human	1.07103347
91	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.06479879
92	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.06161356
93	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.02486235
94	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.02051459
95	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.01677775
96	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.01610852
97	* HOXB7_26014856_ChIP-Seq_BT474_Human	1.01111054
98	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.00787928
99	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.99948189
100	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.99340263

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.07489453
2	MP0002837_dystrophic_cardiac_calcinosis	2.95009467
3	MP0008877_abnormal_DNA_methylation	2.91826065
4	MP0004147_increased_porphyrin_level	2.59514527
5	MP0000569_abnormal_digit_pigmentation	2.54610801
6	MP0000372_irregular_coat_pigmentation	2.42723912
7	MP0003646_muscle_fatigue	2.38244081
8	MP0002102_abnormal_ear_morphology	2.36156088
9	MP0001984_abnormal_olfaction	2.34322655
10	MP0005551_abnormal_eye_electrophysiolog	2.27500200
11	MP0008872_abnormal_physiological_respon	2.17943331
12	MP0005174_abnormal_tail_pigmentation	2.10476474
13	MP0004215_abnormal_myocardial_fiber	2.00729617
14	MP0005084_abnormal_gallbladder_morpholo	1.94839780
15	MP0006072_abnormal_retinal_apoptosis	1.90962256
16	MP0002876_abnormal_thyroid_physiology	1.90496117
17	MP0003787_abnormal_imprinting	1.81703140
18	MP0001968_abnormal_touch/_nociception	1.80699730
19	MP0008875_abnormal_xenobiotic_pharmacok	1.79237103
20	MP0000516_abnormal_urinary_system	1.78184076
21	MP0005367_renal/urinary_system_phenotyp	1.78184076
22	MP0002638_abnormal_pupillary_reflex	1.75198633
23	MP0005253_abnormal_eye_physiology	1.72596666
24	MP0010386_abnormal_urinary_bladder	1.72206367
25	MP0001986_abnormal_taste_sensitivity	1.70686367
26	MP0004043_abnormal_pH_regulation	1.70293885
27	MP0002736_abnormal_nociception_after	1.69823942
28	MP0001529_abnormal_vocalization	1.66014155
29	MP0004142_abnormal_muscle_tone	1.57524636
30	MP0009046_muscle_twitch	1.49888663
31	MP0003252_abnormal_bile_duct	1.48930979
32	MP0005645_abnormal_hypothalamus_physiol	1.43762288
33	MP0005646_abnormal_pituitary_gland	1.41486256
34	MP0001501_abnormal_sleep_pattern	1.36103221
35	MP0002254_reproductive_system_inflammat	1.34357908
36	MP0001486_abnormal_startle_reflex	1.33321672
37	MP0003137_abnormal_impulse_conducting	1.28702203
38	MP0009764_decreased_sensitivity_to	1.27993860
39	MP0004084_abnormal_cardiac_muscle	1.27123644
40	MP0008058_abnormal_DNA_repair	1.26011805
41	MP0006036_abnormal_mitochondrial_physio	1.24995036
42	MP0009745_abnormal_behavioral_response	1.24143064
43	MP0008995_early_reproductive_senescence	1.22373976
44	MP0000230_abnormal_systemic_arterial	1.20091344
45	MP0005410_abnormal_fertilization	1.19259876
46	MP0006276_abnormal_autonomic_nervous	1.18032184
47	MP0003880_abnormal_central_pattern	1.16669675
48	MP0001835_abnormal_antigen_presentation	1.16613929
49	MP0001905_abnormal_dopamine_level	1.16421390
50	MP0002928_abnormal_bile_duct	1.16119942
51	MP0002272_abnormal_nervous_system	1.12673535
52	MP0001970_abnormal_pain_threshold	1.11424172
53	MP0000015_abnormal_ear_pigmentation	1.11219589
54	MP0005365_abnormal_bile_salt	1.09933257
55	MP0001485_abnormal_pinna_reflex	1.09326796
56	MP0003806_abnormal_nucleotide_metabolis	1.08639672
57	MP0004145_abnormal_muscle_electrophysio	1.07149098
58	MP0000427_abnormal_hair_cycle	1.04115971
59	MP0002095_abnormal_skin_pigmentation	1.03441005
60	MP0002735_abnormal_chemical_nociception	1.02649798
61	MP0004133_heterotaxia	0.99921602
62	MP0005332_abnormal_amino_acid	0.96963794
63	MP0005647_abnormal_sex_gland	0.96948005
64	MP0001756_abnormal_urination	0.95361111
65	MP0005386_behavior/neurological_phenoty	0.94663954
66	MP0004924_abnormal_behavior	0.94663954
67	MP0008775_abnormal_heart_ventricle	0.92897210
68	MP0005671_abnormal_response_to	0.92626034
69	MP0006054_spinal_hemorrhage	0.92260356
70	MP0005167_abnormal_blood-brain_barrier	0.90573586
71	MP0010329_abnormal_lipoprotein_level	0.89813521
72	MP0005075_abnormal_melanosome_morpholog	0.89582995
73	MP0003121_genomic_imprinting	0.89326917
74	MP0002277_abnormal_respiratory_mucosa	0.88601826
75	MP0002148_abnormal_hypersensitivity_rea	0.88389908
76	MP0002138_abnormal_hepatobiliary_system	0.85242990
77	MP0005085_abnormal_gallbladder_physiolo	0.84988991
78	MP0002938_white_spotting	0.83675158
79	MP0003718_maternal_effect	0.83177260
80	MP0005389_reproductive_system_phenotype	0.82313522
81	MP0004885_abnormal_endolymph	0.81541459
82	MP0002572_abnormal_emotion/affect_behav	0.80322899
83	MP0003186_abnormal_redox_activity	0.77177168
84	MP0009785_altered_susceptibility_to	0.77111699
85	MP0005636_abnormal_mineral_homeostasis	0.77076033
86	MP0003011_delayed_dark_adaptation	0.76859567
87	MP0001764_abnormal_homeostasis	0.76738433
88	MP0004085_abnormal_heartbeat	0.76241231
89	MP0008789_abnormal_olfactory_epithelium	0.75329108
90	MP0002733_abnormal_thermal_nociception	0.74760785
91	MP0005379_endocrine/exocrine_gland_phen	0.74248918
92	MP0002090_abnormal_vision	0.74120470
93	MP0005195_abnormal_posterior_eye	0.74080814
94	MP0002229_neurodegeneration	0.73206109
95	MP0002557_abnormal_social/conspecific_i	0.72539063
96	MP0005220_abnormal_exocrine_pancreas	0.71931712
97	MP0002163_abnormal_gland_morphology	0.71828725
98	MP0005448_abnormal_energy_balance	0.71048983
99	MP0003786_premature_aging	0.69739627
100	MP0004484_altered_response_of	0.69124021

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.33248819
2	Molar tooth sign on MRI (HP:0002419)	4.09214409
3	Abnormality of midbrain morphology (HP:0002418)	4.09214409
4	Nephronophthisis (HP:0000090)	3.89008010
5	Pancreatic fibrosis (HP:0100732)	3.73211140
6	True hermaphroditism (HP:0010459)	3.69437268
7	Abnormality of the renal cortex (HP:0011035)	3.64961578
8	Abnormality of the renal medulla (HP:0100957)	3.50962198
9	Renal cortical cysts (HP:0000803)	3.46887850
10	Congenital stationary night blindness (HP:0007642)	3.41877841
11	Medial flaring of the eyebrow (HP:0010747)	3.22973680
12	Abolished electroretinogram (ERG) (HP:0000550)	3.20189160
13	Acute necrotizing encephalopathy (HP:0006965)	3.19716889
14	Mitochondrial inheritance (HP:0001427)	3.12596112
15	Progressive macrocephaly (HP:0004481)	3.06775180
16	Increased CSF lactate (HP:0002490)	2.90223767
17	Tubular atrophy (HP:0000092)	2.86319035
18	Renal Fanconi syndrome (HP:0001994)	2.82407064
19	Acute encephalopathy (HP:0006846)	2.80571380
20	Type II lissencephaly (HP:0007260)	2.80193114
21	Increased hepatocellular lipid droplets (HP:0006565)	2.77684792
22	Lipid accumulation in hepatocytes (HP:0006561)	2.75487826
23	Hepatocellular necrosis (HP:0001404)	2.72545788
24	Hepatic necrosis (HP:0002605)	2.70784730
25	Tubulointerstitial nephritis (HP:0001970)	2.70475266
26	Attenuation of retinal blood vessels (HP:0007843)	2.69679560
27	Congenital primary aphakia (HP:0007707)	2.64674818
28	3-Methylglutaconic aciduria (HP:0003535)	2.63560925
29	Abnormal biliary tract physiology (HP:0012439)	2.59796679
30	Bile duct proliferation (HP:0001408)	2.59796679
31	Gait imbalance (HP:0002141)	2.58936297
32	Hypothermia (HP:0002045)	2.51320552
33	Methylmalonic acidemia (HP:0002912)	2.49994286
34	Chronic hepatic failure (HP:0100626)	2.49582038
35	Abnormal mitochondria in muscle tissue (HP:0008316)	2.49252832
36	Nephrogenic diabetes insipidus (HP:0009806)	2.41932223
37	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.40794539
38	Exertional dyspnea (HP:0002875)	2.32488033
39	Disproportionate short-trunk short stature (HP:0003521)	2.31069361
40	Congenital hepatic fibrosis (HP:0002612)	2.30379111
41	Cystic liver disease (HP:0006706)	2.30372982
42	Congenital, generalized hypertrichosis (HP:0004540)	2.30002938
43	Abnormal rod and cone electroretinograms (HP:0008323)	2.27999133
44	Abnormal drinking behavior (HP:0030082)	2.27735388
45	Polydipsia (HP:0001959)	2.27735388
46	Hyperventilation (HP:0002883)	2.24926852
47	Male pseudohermaphroditism (HP:0000037)	2.18555859
48	Genital tract atresia (HP:0001827)	2.13483853
49	Stomatitis (HP:0010280)	2.12548120
50	Inability to walk (HP:0002540)	2.06342929
51	Abnormality of renal resorption (HP:0011038)	2.05595884
52	Metaphyseal dysplasia (HP:0100255)	2.04543109
53	Abnormality of urine glucose concentration (HP:0011016)	2.04281998
54	Glycosuria (HP:0003076)	2.04281998
55	Vaginal atresia (HP:0000148)	2.03397211
56	Absent speech (HP:0001344)	2.02405059
57	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.00766223
58	Optic disc pallor (HP:0000543)	1.99160601
59	Progressive microcephaly (HP:0000253)	1.98799262
60	Progressive inability to walk (HP:0002505)	1.96397816
61	Polyuria (HP:0000103)	1.95046803
62	Cerebral edema (HP:0002181)	1.92770903
63	Lissencephaly (HP:0001339)	1.92651007
64	Cerebellar dysplasia (HP:0007033)	1.91977530
65	Methylmalonic aciduria (HP:0012120)	1.91725780
66	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.88694234
67	Abnormal protein N-linked glycosylation (HP:0012347)	1.88694234
68	Abnormal protein glycosylation (HP:0012346)	1.88694234
69	Abnormal glycosylation (HP:0012345)	1.88694234
70	Fair hair (HP:0002286)	1.88135268
71	Increased serum lactate (HP:0002151)	1.87820673
72	Widely spaced teeth (HP:0000687)	1.86734919
73	CNS demyelination (HP:0007305)	1.86309424
74	Keratoconus (HP:0000563)	1.86232513
75	Increased corneal curvature (HP:0100692)	1.86232513
76	Lactic acidosis (HP:0003128)	1.83485806
77	Hypomagnesemia (HP:0002917)	1.82677276
78	Stomach cancer (HP:0012126)	1.81221745
79	Protruding tongue (HP:0010808)	1.80909687
80	Furrowed tongue (HP:0000221)	1.80556325
81	Ketosis (HP:0001946)	1.80283120
82	Hypoplastic iliac wings (HP:0002866)	1.79854633
83	Intestinal atresia (HP:0011100)	1.79412101
84	Sclerocornea (HP:0000647)	1.79218410
85	Hyperglycinemia (HP:0002154)	1.79171813
86	Tubulointerstitial abnormality (HP:0001969)	1.78559233
87	Hypoproteinemia (HP:0003075)	1.77298981
88	Facial diplegia (HP:0001349)	1.77009595
89	Large for gestational age (HP:0001520)	1.75679131
90	Gaze-evoked nystagmus (HP:0000640)	1.73742534
91	Thyroiditis (HP:0100646)	1.71786590
92	Lethargy (HP:0001254)	1.69875518
93	Postaxial foot polydactyly (HP:0001830)	1.69536908
94	Volvulus (HP:0002580)	1.67826729
95	Decreased central vision (HP:0007663)	1.66972372
96	Opisthotonus (HP:0002179)	1.66368977
97	Constricted visual fields (HP:0001133)	1.66194667
98	Anencephaly (HP:0002323)	1.65986898
99	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.65407479
100	Abnormality of the prostate (HP:0008775)	1.64964045

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.93085398
2	FRK	4.72111953
3	NUAK1	2.85488789
4	BMPR1B	2.75601231
5	ACVR1B	2.39941039
6	WNK3	2.26379004
7	ADRBK2	2.10871538
8	TAOK3	2.04887032
9	PINK1	2.01832689
10	WNK4	1.92955256
11	ZAK	1.87001704
12	BCKDK	1.80555575
13	TXK	1.74610845
14	GRK1	1.74155612
15	MAPK13	1.73709285
16	INSRR	1.73203370
17	ERBB3	1.66260140
18	OXSR1	1.54447474
19	CASK	1.52857887
20	TLK1	1.51519297
21	MKNK2	1.36716822
22	MST4	1.33470769
23	TRIM28	1.31996024
24	CAMKK2	1.31948630
25	MUSK	1.29793079
26	TEC	1.29075601
27	STK16	1.25188968
28	PAK3	1.25045123
29	CCNB1	1.18439307
30	STK39	1.17034213
31	STK38L	1.11954943
32	MAP3K4	1.10760674
33	TNIK	1.03886958
34	TGFBR1	1.03186040
35	VRK1	1.03178637
36	FLT3	1.03045176
37	BMPR2	1.02619755
38	CSNK1G2	1.01630478
39	ADRBK1	0.97180641
40	BRSK2	0.97167928
41	IKBKB	0.96628448
42	CSNK1G1	0.93430622
43	PRKCE	0.91143865
44	PLK2	0.90094590
45	CSNK1G3	0.87262810
46	MKNK1	0.83804155
47	CSNK1A1L	0.82244160
48	PRKCQ	0.80485958
49	KIT	0.78858350
50	FGFR2	0.77735412
51	OBSCN	0.77266187
52	EIF2AK3	0.74275109
53	ITK	0.73257890
54	MAP2K6	0.73192716
55	PTK2B	0.71418631
56	GRK7	0.68120567
57	AKT3	0.66711409
58	DAPK2	0.66258993
59	PIK3CG	0.65908837
60	TNK2	0.64543137
61	TIE1	0.64108549
62	PLK3	0.63186708
63	NTRK3	0.63121646
64	PIK3CA	0.62032228
65	TRPM7	0.61206598
66	STK3	0.59506367
67	MYLK	0.58328873
68	SYK	0.57554502
69	NEK2	0.56896406
70	PRKCG	0.55398873
71	PLK4	0.55033425
72	IGF1R	0.53108265
73	PRKG1	0.50139633
74	CSF1R	0.49659807
75	IKBKE	0.47767286
76	BCR	0.46467342
77	ABL1	0.46248311
78	DYRK2	0.44275481
79	CSNK1A1	0.44253789
80	CHUK	0.43625590
81	PRKACA	0.42912831
82	MAPK15	0.42115981
83	CAMK2A	0.41396823
84	LYN	0.41151825
85	SRPK1	0.40755766
86	RPS6KA5	0.40557218
87	MARK3	0.39782534
88	MAPKAPK5	0.37912509
89	CAMK1	0.37333855
90	ROCK1	0.37188603
91	PHKG2	0.36478152
92	PHKG1	0.36478152
93	BLK	0.35581788
94	PKN1	0.35304568
95	CSNK1D	0.34797627
96	PRKCA	0.33852379
97	MAP2K7	0.33721022
98	ATM	0.33027639
99	PRKAA2	0.32213040
100	MAP3K12	0.31201819

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.14203194
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.60450835
3	Protein export_Homo sapiens_hsa03060	2.54721557
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.38245227
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.33768252
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.32461063
7	Butanoate metabolism_Homo sapiens_hsa00650	2.24555878
8	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.06885535
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.00727801
10	Propanoate metabolism_Homo sapiens_hsa00640	2.00058551
11	Phototransduction_Homo sapiens_hsa04744	1.99707301
12	Type I diabetes mellitus_Homo sapiens_hsa04940	1.98449789
13	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.96071181
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.93527443
15	Allograft rejection_Homo sapiens_hsa05330	1.85204570
16	Parkinsons disease_Homo sapiens_hsa05012	1.84318104
17	Peroxisome_Homo sapiens_hsa04146	1.78311162
18	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.75612859
19	Graft-versus-host disease_Homo sapiens_hsa05332	1.73571869
20	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.71838263
21	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.62186083
22	Homologous recombination_Homo sapiens_hsa03440	1.61791784
23	Tryptophan metabolism_Homo sapiens_hsa00380	1.60894966
24	Regulation of autophagy_Homo sapiens_hsa04140	1.55414456
25	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.54706421
26	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.53416433
27	Nitrogen metabolism_Homo sapiens_hsa00910	1.47396712
28	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.45475422
29	Fanconi anemia pathway_Homo sapiens_hsa03460	1.41404831
30	RNA polymerase_Homo sapiens_hsa03020	1.40250976
31	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.39328551
32	RNA degradation_Homo sapiens_hsa03018	1.39013506
33	Ether lipid metabolism_Homo sapiens_hsa00565	1.31265914
34	Rheumatoid arthritis_Homo sapiens_hsa05323	1.30774562
35	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.30394285
36	Selenocompound metabolism_Homo sapiens_hsa00450	1.26441448
37	Basal transcription factors_Homo sapiens_hsa03022	1.25350090
38	Caffeine metabolism_Homo sapiens_hsa00232	1.24570297
39	Nicotine addiction_Homo sapiens_hsa05033	1.17862005
40	Huntingtons disease_Homo sapiens_hsa05016	1.17439798
41	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.12682455
42	Alzheimers disease_Homo sapiens_hsa05010	1.12363205
43	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.10489475
44	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.08597879
45	Proteasome_Homo sapiens_hsa03050	1.07311361
46	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.05715600
47	Cardiac muscle contraction_Homo sapiens_hsa04260	1.05414367
48	Collecting duct acid secretion_Homo sapiens_hsa04966	1.05263738
49	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.03701484
50	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.00321078
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.98275746
52	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.97670676
53	Olfactory transduction_Homo sapiens_hsa04740	0.96988230
54	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.95444318
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.95053286
56	Taste transduction_Homo sapiens_hsa04742	0.94090774
57	ABC transporters_Homo sapiens_hsa02010	0.91910218
58	Circadian rhythm_Homo sapiens_hsa04710	0.82552016
59	beta-Alanine metabolism_Homo sapiens_hsa00410	0.79454108
60	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.78022408
61	Retinol metabolism_Homo sapiens_hsa00830	0.76486450
62	Purine metabolism_Homo sapiens_hsa00230	0.75690985
63	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.74418353
64	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.74235222
65	Non-homologous end-joining_Homo sapiens_hsa03450	0.72284889
66	Salivary secretion_Homo sapiens_hsa04970	0.69522121
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.68959558
68	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.68657919
69	Sulfur metabolism_Homo sapiens_hsa00920	0.68404447
70	Fatty acid elongation_Homo sapiens_hsa00062	0.67990661
71	Fatty acid degradation_Homo sapiens_hsa00071	0.67936639
72	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.66154502
73	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.64222335
74	One carbon pool by folate_Homo sapiens_hsa00670	0.63849235
75	Insulin secretion_Homo sapiens_hsa04911	0.62020086
76	Metabolic pathways_Homo sapiens_hsa01100	0.61316093
77	Serotonergic synapse_Homo sapiens_hsa04726	0.60902114
78	Morphine addiction_Homo sapiens_hsa05032	0.59642539
79	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.59159902
80	Circadian entrainment_Homo sapiens_hsa04713	0.58460965
81	Antigen processing and presentation_Homo sapiens_hsa04612	0.57975096
82	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.57934897
83	Glutathione metabolism_Homo sapiens_hsa00480	0.55708999
84	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.52462192
85	Glycerolipid metabolism_Homo sapiens_hsa00561	0.52400045
86	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.50034802
87	GABAergic synapse_Homo sapiens_hsa04727	0.48494344
88	Steroid biosynthesis_Homo sapiens_hsa00100	0.47995979
89	Primary immunodeficiency_Homo sapiens_hsa05340	0.47375039
90	Histidine metabolism_Homo sapiens_hsa00340	0.44447805
91	Viral myocarditis_Homo sapiens_hsa05416	0.43777526
92	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.43565464
93	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.42507079
94	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.41581070
95	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.41391497
96	Calcium signaling pathway_Homo sapiens_hsa04020	0.40208154
97	Fatty acid metabolism_Homo sapiens_hsa01212	0.37962767
98	Legionellosis_Homo sapiens_hsa05134	0.37166616
99	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.32660484
100	Leishmaniasis_Homo sapiens_hsa05140	0.32292320

ZNF846

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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