ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of hippo signaling (GO:0035330)	6.87669552
2	preassembly of GPI anchor in ER membrane (GO:0016254)	5.91941628
3	cytoplasmic mRNA processing body assembly (GO:0033962)	5.43855051
4	histone H2A acetylation (GO:0043968)	5.26519435
5	regulation of centriole replication (GO:0046599)	4.99528527
6	regulation of posttranscriptional gene silencing (GO:0060147)	4.96485462
7	regulation of gene silencing by miRNA (GO:0060964)	4.96485462
8	regulation of gene silencing by RNA (GO:0060966)	4.96485462
9	mannosylation (GO:0097502)	4.51894193
10	kinetochore organization (GO:0051383)	4.38349866
11	protein K6-linked ubiquitination (GO:0085020)	4.29337059
12	positive regulation of histone H3-K4 methylation (GO:0051571)	4.17226978
13	L-fucose catabolic process (GO:0042355)	4.08163281
14	fucose catabolic process (GO:0019317)	4.08163281
15	L-fucose metabolic process (GO:0042354)	4.08163281
16	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	3.99196863
17	GPI anchor metabolic process (GO:0006505)	3.97681113
18	negative regulation of histone acetylation (GO:0035067)	3.96005926
19	GPI anchor biosynthetic process (GO:0006506)	3.92158188
20	response to pheromone (GO:0019236)	3.84687266
21	C-terminal protein amino acid modification (GO:0018410)	3.82254322
22	regulation of RIG-I signaling pathway (GO:0039535)	3.82120518
23	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.79434202
24	behavioral response to nicotine (GO:0035095)	3.76391625
25	neural tube formation (GO:0001841)	3.75783782
26	meiotic chromosome segregation (GO:0045132)	3.72227765
27	righting reflex (GO:0060013)	3.68171670
28	C-terminal protein lipidation (GO:0006501)	3.61588033
29	chromatin remodeling at centromere (GO:0031055)	3.58184943
30	CENP-A containing nucleosome assembly (GO:0034080)	3.50982308
31	behavioral response to ethanol (GO:0048149)	3.50578203
32	somite development (GO:0061053)	3.47043362
33	regulation of DNA endoreduplication (GO:0032875)	3.38362083
34	centriole replication (GO:0007099)	3.38115051
35	histone exchange (GO:0043486)	3.34935791
36	RNA-dependent DNA replication (GO:0006278)	3.34147887
37	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.31478744
38	alanine transport (GO:0032328)	3.31383984
39	negative regulation of peptidyl-lysine acetylation (GO:2000757)	3.28915946
40	positive regulation of respiratory burst (GO:0060267)	3.28198172
41	viral mRNA export from host cell nucleus (GO:0046784)	3.20886537
42	negative regulation of protein acetylation (GO:1901984)	3.11889513
43	regulation of protein polyubiquitination (GO:1902914)	3.09962987
44	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.09073639
45	regulation of mitotic spindle checkpoint (GO:1903504)	3.09073639
46	peptidyl-histidine modification (GO:0018202)	3.01284578
47	glycolipid biosynthetic process (GO:0009247)	2.95485855
48	cornea development in camera-type eye (GO:0061303)	2.95111582
49	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.93160815
50	peristalsis (GO:0030432)	2.89240601
51	dermatan sulfate biosynthetic process (GO:0030208)	2.86884902
52	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.85844722
53	substrate-independent telencephalic tangential migration (GO:0021826)	2.85844722
54	histone H3-K9 methylation (GO:0051567)	2.84622836
55	protein targeting to peroxisome (GO:0006625)	2.83901481
56	establishment of protein localization to peroxisome (GO:0072663)	2.83901481
57	protein localization to peroxisome (GO:0072662)	2.83901481
58	protein localization to cilium (GO:0061512)	2.82963024
59	protein-cofactor linkage (GO:0018065)	2.81773356
60	DNA double-strand break processing (GO:0000729)	2.80113258
61	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.79543954
62	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.79097671
63	platelet dense granule organization (GO:0060155)	2.78813568
64	kinetochore assembly (GO:0051382)	2.78650566
65	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.76619209
66	histone H2A ubiquitination (GO:0033522)	2.76208348
67	aggressive behavior (GO:0002118)	2.75697797
68	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	2.73074081
69	regulation of centrosome duplication (GO:0010824)	2.71896969
70	gene silencing by RNA (GO:0031047)	2.71253264
71	photoreceptor cell maintenance (GO:0045494)	2.69550182
72	response to X-ray (GO:0010165)	2.69522592
73	regulation of centrosome cycle (GO:0046605)	2.68952763
74	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.68889264
75	cholesterol biosynthetic process (GO:0006695)	2.68143052
76	DNA ligation (GO:0006266)	2.67324851
77	negative regulation of macrophage differentiation (GO:0045650)	2.65740190
78	serotonin receptor signaling pathway (GO:0007210)	2.64294164
79	sphingoid metabolic process (GO:0046519)	2.62571888
80	regulation of hexokinase activity (GO:1903299)	2.62310859
81	regulation of glucokinase activity (GO:0033131)	2.62310859
82	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.61167220
83	urinary tract smooth muscle contraction (GO:0014848)	2.60677273
84	mechanosensory behavior (GO:0007638)	2.59893942
85	regulation of gene silencing (GO:0060968)	2.58683698
86	water-soluble vitamin biosynthetic process (GO:0042364)	2.58587973
87	microtubule depolymerization (GO:0007019)	2.58335584
88	centriole assembly (GO:0098534)	2.55009168
89	replication fork processing (GO:0031297)	2.54419955
90	postreplication repair (GO:0006301)	2.51387194
91	protein complex biogenesis (GO:0070271)	2.50347318
92	male meiosis (GO:0007140)	2.48815451
93	protein localization to kinetochore (GO:0034501)	2.47494905
94	diol metabolic process (GO:0034311)	2.46582517
95	glial cell proliferation (GO:0014009)	2.46101762
96	limb bud formation (GO:0060174)	2.45776114
97	double-strand break repair via homologous recombination (GO:0000724)	2.44004330
98	recombinational repair (GO:0000725)	2.43498879
99	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	2.42175354
100	attachment of spindle microtubules to kinetochore (GO:0008608)	2.41363489

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	7.64176428
2	ZNF274_21170338_ChIP-Seq_K562_Hela	4.07399278
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.94262155
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.89116056
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.77703265
6	VDR_22108803_ChIP-Seq_LS180_Human	2.47965693
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.47634957
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.47048883
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.46557204
10	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.44209388
11	ELK1_19687146_ChIP-ChIP_HELA_Human	2.44053109
12	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.33390210
13	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.31706137
14	TAF15_26573619_Chip-Seq_HEK293_Human	2.26081061
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.22525790
16	FUS_26573619_Chip-Seq_HEK293_Human	2.20832854
17	EWS_26573619_Chip-Seq_HEK293_Human	2.14302849
18	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.12660139
19	P300_19829295_ChIP-Seq_ESCs_Human	1.96474448
20	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.94667759
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.94073722
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.90660904
23	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.88973870
24	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.86988863
25	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.81674641
26	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.75527950
27	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.74084031
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.68871613
29	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.62409081
30	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.59795559
31	VDR_23849224_ChIP-Seq_CD4+_Human	1.55947751
32	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.49281113
33	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.49072095
34	CBP_20019798_ChIP-Seq_JUKART_Human	1.49072095
35	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.47782498
36	ER_23166858_ChIP-Seq_MCF-7_Human	1.47500855
37	RNF2_27304074_Chip-Seq_NSC_Mouse	1.45150274
38	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.39693094
39	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.38391485
40	AR_25329375_ChIP-Seq_VCAP_Human	1.37262094
41	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.37207948
42	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.35759667
43	NANOG_19829295_ChIP-Seq_ESCs_Human	1.35387056
44	SOX2_19829295_ChIP-Seq_ESCs_Human	1.35387056
45	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.33802470
46	AR_21572438_ChIP-Seq_LNCaP_Human	1.33540543
47	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.33287173
48	MYC_18940864_ChIP-ChIP_HL60_Human	1.32467552
49	HTT_18923047_ChIP-ChIP_STHdh_Human	1.30643030
50	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.28322639
51	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.28322639
52	BCAT_22108803_ChIP-Seq_LS180_Human	1.27733168
53	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.27283147
54	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.27120107
55	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.26848492
56	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.24137216
57	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.22784698
58	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.22389012
59	SMAD4_21799915_ChIP-Seq_A2780_Human	1.22105279
60	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.21479772
61	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.19136351
62	E2F7_22180533_ChIP-Seq_HELA_Human	1.18785384
63	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.18105686
64	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.17486042
65	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.17258269
66	TCF4_23295773_ChIP-Seq_U87_Human	1.14735192
67	TP53_22573176_ChIP-Seq_HFKS_Human	1.14358814
68	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13840992
69	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.13632883
70	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.13292335
71	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.13217614
72	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.09514801
73	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.09164162
74	AR_20517297_ChIP-Seq_VCAP_Human	1.08941123
75	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.08863494
76	RUNX2_22187159_ChIP-Seq_PCA_Human	1.08856786
77	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.08777709
78	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.08753543
79	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.08714146
80	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.07580077
81	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.06993304
82	FOXP3_21729870_ChIP-Seq_TREG_Human	1.06974768
83	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.06250108
84	STAT3_23295773_ChIP-Seq_U87_Human	1.05862570
85	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.04378843
86	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.03007595
87	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01913595
88	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.01891871
89	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.01216096
90	TCF4_22108803_ChIP-Seq_LS180_Human	0.99482009
91	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.99120211
92	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.98953426
93	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.98060280
94	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.97737067
95	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.97249439
96	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.96093923
97	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.96009914
98	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.95267835
99	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.95253053
100	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.94757651

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.51087829
2	MP0000372_irregular_coat_pigmentation	2.98726509
3	MP0001529_abnormal_vocalization	2.96362915
4	MP0008877_abnormal_DNA_methylation	2.76857722
5	MP0004147_increased_porphyrin_level	2.67234119
6	MP0005503_abnormal_tendon_morphology	2.40263607
7	MP0003195_calcinosis	2.39281667
8	MP0000383_abnormal_hair_follicle	2.38624831
9	MP0006072_abnormal_retinal_apoptosis	2.31590059
10	MP0002876_abnormal_thyroid_physiology	2.22277019
11	MP0002009_preneoplasia	2.17354716
12	MP0003718_maternal_effect	2.02800335
13	MP0005253_abnormal_eye_physiology	2.02728881
14	MP0000427_abnormal_hair_cycle	1.99635546
15	MP0002254_reproductive_system_inflammat	1.99507634
16	MP0005275_abnormal_skin_tensile	1.97642693
17	MP0010094_abnormal_chromosome_stability	1.96831688
18	MP0002163_abnormal_gland_morphology	1.90888627
19	MP0002102_abnormal_ear_morphology	1.87179992
20	MP0005551_abnormal_eye_electrophysiolog	1.85876163
21	MP0000631_abnormal_neuroendocrine_gland	1.82107836
22	MP0004142_abnormal_muscle_tone	1.74196948
23	MP0005646_abnormal_pituitary_gland	1.71997335
24	MP0001293_anophthalmia	1.70989426
25	MP0002822_catalepsy	1.68960340
26	MP0000613_abnormal_salivary_gland	1.65632375
27	MP0008058_abnormal_DNA_repair	1.64297106
28	MP0000566_synostosis	1.62662386
29	MP0003880_abnormal_central_pattern	1.62163849
30	MP0002234_abnormal_pharynx_morphology	1.61254756
31	MP0009046_muscle_twitch	1.56528875
32	MP0004133_heterotaxia	1.56270395
33	MP0002938_white_spotting	1.55377990
34	MP0010678_abnormal_skin_adnexa	1.53312639
35	MP0003283_abnormal_digestive_organ	1.51997500
36	MP0004043_abnormal_pH_regulation	1.50339215
37	MP0006276_abnormal_autonomic_nervous	1.48354726
38	MP0006054_spinal_hemorrhage	1.46006479
39	MP0003950_abnormal_plasma_membrane	1.44084054
40	MP0002160_abnormal_reproductive_system	1.42446370
41	MP0005379_endocrine/exocrine_gland_phen	1.41354824
42	MP0001968_abnormal_touch/_nociception	1.39249428
43	MP0001177_atelectasis	1.38732180
44	MP0010030_abnormal_orbit_morphology	1.34796773
45	MP0003787_abnormal_imprinting	1.34774750
46	MP0003567_abnormal_fetal_cardiomyocyte	1.34539920
47	MP0002736_abnormal_nociception_after	1.32800213
48	MP0001486_abnormal_startle_reflex	1.32316205
49	MP0002751_abnormal_autonomic_nervous	1.29612065
50	MP0001929_abnormal_gametogenesis	1.24097002
51	MP0002735_abnormal_chemical_nociception	1.22851177
52	MP0003937_abnormal_limbs/digits/tail_de	1.20180290
53	MP0003011_delayed_dark_adaptation	1.19422417
54	MP0003693_abnormal_embryo_hatching	1.17425043
55	MP0005389_reproductive_system_phenotype	1.13676798
56	MP0004270_analgesia	1.11288939
57	MP0000653_abnormal_sex_gland	1.10513382
58	MP0002638_abnormal_pupillary_reflex	1.09636619
59	MP0009745_abnormal_behavioral_response	1.08194756
60	MP0001346_abnormal_lacrimal_gland	1.07444896
61	MP0001145_abnormal_male_reproductive	1.05941030
62	MP0008789_abnormal_olfactory_epithelium	1.04568841
63	MP0002272_abnormal_nervous_system	1.04073582
64	MP0005391_vision/eye_phenotype	1.03752512
65	MP0003698_abnormal_male_reproductive	1.02280153
66	MP0002277_abnormal_respiratory_mucosa	1.01615645
67	MP0002210_abnormal_sex_determination	0.99260257
68	MP0001324_abnormal_eye_pigmentation	0.98909683
69	MP0008872_abnormal_physiological_respon	0.97506241
70	MP0002108_abnormal_muscle_morphology	0.96295905
71	MP0000647_abnormal_sebaceous_gland	0.95854826
72	MP0003786_premature_aging	0.93690052
73	MP0005195_abnormal_posterior_eye	0.92838308
74	MP0000569_abnormal_digit_pigmentation	0.92200920
75	MP0010386_abnormal_urinary_bladder	0.91713615
76	MP0005410_abnormal_fertilization	0.91411668
77	MP0003943_abnormal_hepatobiliary_system	0.87354717
78	MP0003121_genomic_imprinting	0.85744157
79	MP0003119_abnormal_digestive_system	0.85013922
80	MP0002734_abnormal_mechanical_nocicepti	0.84568362
81	MP0000470_abnormal_stomach_morphology	0.84421728
82	MP0001243_abnormal_dermal_layer	0.82768961
83	MP0005248_abnormal_Harderian_gland	0.80550853
84	MP0002282_abnormal_trachea_morphology	0.80358955
85	MP0003136_yellow_coat_color	0.80252888
86	MP0001919_abnormal_reproductive_system	0.79993747
87	MP0002166_altered_tumor_susceptibility	0.79745104
88	MP0003890_abnormal_embryonic-extraembry	0.77883247
89	MP0000639_abnormal_adrenal_gland	0.77192774
90	MP0001119_abnormal_female_reproductive	0.77001763
91	MP0000778_abnormal_nervous_system	0.75171746
92	MP0001986_abnormal_taste_sensitivity	0.75169264
93	MP0001485_abnormal_pinna_reflex	0.73425068
94	MP0002557_abnormal_social/conspecific_i	0.73290677
95	MP0002837_dystrophic_cardiac_calcinosis	0.73206869
96	MP0005220_abnormal_exocrine_pancreas	0.73063315
97	MP0003137_abnormal_impulse_conducting	0.70880144
98	MP0001764_abnormal_homeostasis	0.70773104
99	MP0001286_abnormal_eye_development	0.70376645
100	MP0003191_abnormal_cellular_cholesterol	0.70363941

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.03644727
2	Pancreatic fibrosis (HP:0100732)	3.79682182
3	Supernumerary spleens (HP:0009799)	3.79332180
4	True hermaphroditism (HP:0010459)	3.79105998
5	Abnormality of alanine metabolism (HP:0010916)	3.65258809
6	Hyperalaninemia (HP:0003348)	3.65258809
7	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.65258809
8	Molar tooth sign on MRI (HP:0002419)	3.61405234
9	Abnormality of midbrain morphology (HP:0002418)	3.61405234
10	3-Methylglutaconic aciduria (HP:0003535)	3.35551756
11	Abnormal biliary tract physiology (HP:0012439)	3.17808943
12	Bile duct proliferation (HP:0001408)	3.17808943
13	Abnormality of the renal cortex (HP:0011035)	3.13273010
14	Nephronophthisis (HP:0000090)	2.99757200
15	Abnormality of the labia minora (HP:0012880)	2.91801411
16	Adrenal hypoplasia (HP:0000835)	2.90594582
17	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.90168979
18	Short tibia (HP:0005736)	2.88683326
19	Large for gestational age (HP:0001520)	2.86771144
20	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.84610392
21	Abnormality of the renal medulla (HP:0100957)	2.79478887
22	Medial flaring of the eyebrow (HP:0010747)	2.78583803
23	Hypothermia (HP:0002045)	2.64901962
24	Occipital encephalocele (HP:0002085)	2.64326073
25	Oligodactyly (HP:0012165)	2.50054681
26	Congenital primary aphakia (HP:0007707)	2.49854223
27	Renal cortical cysts (HP:0000803)	2.49269726
28	Abolished electroretinogram (ERG) (HP:0000550)	2.49080023
29	Congenital, generalized hypertrichosis (HP:0004540)	2.44413147
30	Gait imbalance (HP:0002141)	2.43065176
31	Tubular atrophy (HP:0000092)	2.32268897
32	Cystic liver disease (HP:0006706)	2.29067633
33	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.25141934
34	Hypoplasia of the fovea (HP:0007750)	2.25141934
35	Abnormality of the fovea (HP:0000493)	2.23638972
36	Nephrogenic diabetes insipidus (HP:0009806)	2.23636972
37	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.22910612
38	Parakeratosis (HP:0001036)	2.21286142
39	Patellar aplasia (HP:0006443)	2.20869313
40	Hypoplastic pelvis (HP:0008839)	2.20853673
41	Sclerocornea (HP:0000647)	2.18203278
42	Male pseudohermaphroditism (HP:0000037)	2.16682859
43	Acute necrotizing encephalopathy (HP:0006965)	2.16394660
44	Duplicated collecting system (HP:0000081)	2.16120673
45	Absent septum pellucidum (HP:0001331)	2.13593115
46	Genital tract atresia (HP:0001827)	2.11235273
47	Scotoma (HP:0000575)	2.11115062
48	Vaginal atresia (HP:0000148)	2.10980157
49	Anencephaly (HP:0002323)	2.10564377
50	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.07729594
51	Abnormality of the renal collecting system (HP:0004742)	2.05818703
52	Chromsome breakage (HP:0040012)	2.02556482
53	Postaxial hand polydactyly (HP:0001162)	1.99487745
54	Postaxial foot polydactyly (HP:0001830)	1.97506116
55	Methylmalonic acidemia (HP:0002912)	1.96249916
56	Congenital stationary night blindness (HP:0007642)	1.96182353
57	Progressive macrocephaly (HP:0004481)	1.92699494
58	Aplasia/Hypoplasia of the patella (HP:0006498)	1.92573881
59	Dandy-Walker malformation (HP:0001305)	1.91234148
60	Rhinitis (HP:0012384)	1.87903504
61	Leukodystrophy (HP:0002415)	1.87172163
62	Progressive inability to walk (HP:0002505)	1.84513169
63	Abnormality of the septum pellucidum (HP:0007375)	1.83867154
64	Decreased testicular size (HP:0008734)	1.82296086
65	Aplasia/hypoplasia of the uterus (HP:0008684)	1.81529816
66	Broad-based gait (HP:0002136)	1.81424832
67	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.80347244
68	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.80054755
69	Congenital hepatic fibrosis (HP:0002612)	1.79651397
70	Hypoplastic labia majora (HP:0000059)	1.79468825
71	Furrowed tongue (HP:0000221)	1.79287412
72	Spastic paraparesis (HP:0002313)	1.78644336
73	Central scotoma (HP:0000603)	1.77652982
74	Azoospermia (HP:0000027)	1.76106479
75	Type II lissencephaly (HP:0007260)	1.75146028
76	Hypsarrhythmia (HP:0002521)	1.73809310
77	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.73458472
78	Abnormality of serum amino acid levels (HP:0003112)	1.73423434
79	Abnormality of the pons (HP:0007361)	1.72172545
80	Hypoplasia of the uterus (HP:0000013)	1.69493472
81	Dyschromatopsia (HP:0007641)	1.66606170
82	Chronic hepatic failure (HP:0100626)	1.64852723
83	Brushfield spots (HP:0001088)	1.64307179
84	Asplenia (HP:0001746)	1.64290776
85	Anal atresia (HP:0002023)	1.64124246
86	Abnormality of macular pigmentation (HP:0008002)	1.63971289
87	Abnormality of methionine metabolism (HP:0010901)	1.63143511
88	Volvulus (HP:0002580)	1.62874453
89	Polydipsia (HP:0001959)	1.62298850
90	Abnormal drinking behavior (HP:0030082)	1.62298850
91	EEG with generalized epileptiform discharges (HP:0011198)	1.62246683
92	Muscular hypotonia of the trunk (HP:0008936)	1.62229284
93	Acute encephalopathy (HP:0006846)	1.62120363
94	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.61961299
95	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.61961299
96	Synostosis involving the elbow (HP:0003938)	1.60263500
97	Humeroradial synostosis (HP:0003041)	1.60263500
98	Abnormality of the metopic suture (HP:0005556)	1.59556138
99	Aganglionic megacolon (HP:0002251)	1.58051741
100	Broad foot (HP:0001769)	1.57994204

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIM28	3.94097993
2	BCR	2.84463090
3	FRK	2.59354840
4	WNK3	2.53670080
5	WEE1	2.47807736
6	PINK1	2.46848110
7	PLK4	2.45829028
8	PBK	2.31860644
9	ERBB3	2.23235964
10	CASK	2.20328139
11	NUAK1	2.19716635
12	MAP4K2	2.16280532
13	STK16	2.08372396
14	PLK3	2.06544707
15	ZAK	2.04399713
16	ADRBK2	1.90982056
17	CDK3	1.86153770
18	BRSK2	1.71405444
19	CDC7	1.69142396
20	TSSK6	1.64545367
21	PLK2	1.55673230
22	PNCK	1.55323420
23	VRK1	1.55245285
24	WNK4	1.52687415
25	GRK1	1.47637713
26	INSRR	1.43030069
27	FGFR2	1.40607616
28	MAPK13	1.34211504
29	OXSR1	1.33834409
30	TTK	1.30934890
31	PASK	1.30180392
32	MKNK1	1.29998824
33	BCKDK	1.25765349
34	MST4	1.24061821
35	MAP3K4	1.23120788
36	EIF2AK1	1.12282375
37	CSNK1G1	1.06105723
38	STK39	1.06094019
39	MKNK2	1.05685696
40	PAK3	0.99456513
41	BUB1	0.97293472
42	BMPR1B	0.93634304
43	PKN1	0.93232679
44	PLK1	0.92313077
45	TNIK	0.91360385
46	ATR	0.90884985
47	CHEK2	0.88751353
48	CAMKK2	0.86829651
49	SIK3	0.84128906
50	TIE1	0.82789315
51	RPS6KA5	0.82503196
52	EIF2AK3	0.82480743
53	CCNB1	0.79933189
54	TLK1	0.77048778
55	AURKB	0.76746070
56	SRPK1	0.71716979
57	CSNK1G2	0.69349809
58	ATM	0.65809417
59	CSNK1G3	0.65352992
60	STK3	0.64779982
61	MAP2K7	0.63602535
62	PRKCE	0.62154402
63	MAPK15	0.61583559
64	MINK1	0.60697772
65	PRKCG	0.60114265
66	CSNK1A1	0.53636230
67	FER	0.52806101
68	CSNK2A1	0.51109329
69	PHKG1	0.51069958
70	PHKG2	0.51069958
71	FLT3	0.50764118
72	PRKAA1	0.47832872
73	UHMK1	0.46826745
74	TGFBR1	0.46767282
75	CAMK2A	0.46728912
76	GRK5	0.45581614
77	CSNK1A1L	0.45025069
78	MAPKAPK5	0.44622990
79	STK4	0.44275749
80	EPHA4	0.43094160
81	DYRK2	0.42778870
82	NEK9	0.41595217
83	CDK1	0.40688615
84	PRKCI	0.40358820
85	CSF1R	0.40180283
86	YES1	0.40033561
87	AURKA	0.39592652
88	MUSK	0.39210243
89	PRKDC	0.39072644
90	PTK2B	0.39005567
91	MARK3	0.38589725
92	CDK6	0.37998190
93	CHUK	0.36195388
94	PRKACB	0.36062445
95	PRKACA	0.35823187
96	DYRK3	0.35603592
97	CHEK1	0.35519552
98	MAP3K12	0.34693832
99	CSNK1E	0.32831208
100	DYRK1B	0.32376934

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	4.33380043
2	Protein export_Homo sapiens_hsa03060	4.00192901
3	Steroid biosynthesis_Homo sapiens_hsa00100	3.26942045
4	Basal transcription factors_Homo sapiens_hsa03022	2.53751629
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.32722143
6	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.26376102
7	Homologous recombination_Homo sapiens_hsa03440	2.12074574
8	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.10703436
9	Non-homologous end-joining_Homo sapiens_hsa03450	2.10542206
10	RNA degradation_Homo sapiens_hsa03018	2.09522615
11	Proteasome_Homo sapiens_hsa03050	2.05369069
12	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.04419847
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.00247398
14	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.90968110
15	Fanconi anemia pathway_Homo sapiens_hsa03460	1.90551328
16	Oxidative phosphorylation_Homo sapiens_hsa00190	1.75160812
17	Propanoate metabolism_Homo sapiens_hsa00640	1.59066912
18	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.57231850
19	Phototransduction_Homo sapiens_hsa04744	1.48869988
20	Nitrogen metabolism_Homo sapiens_hsa00910	1.43827992
21	RNA polymerase_Homo sapiens_hsa03020	1.40937233
22	Asthma_Homo sapiens_hsa05310	1.40567617
23	Spliceosome_Homo sapiens_hsa03040	1.38874259
24	Mismatch repair_Homo sapiens_hsa03430	1.36494577
25	Caffeine metabolism_Homo sapiens_hsa00232	1.35627235
26	Nicotine addiction_Homo sapiens_hsa05033	1.33916108
27	Taste transduction_Homo sapiens_hsa04742	1.33095915
28	Peroxisome_Homo sapiens_hsa04146	1.32756547
29	RNA transport_Homo sapiens_hsa03013	1.31789616
30	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.29313866
31	Parkinsons disease_Homo sapiens_hsa05012	1.28557944
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.25877986
33	Selenocompound metabolism_Homo sapiens_hsa00450	1.25343025
34	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.24302186
35	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.10194050
36	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.09362392
37	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.05573113
38	Butanoate metabolism_Homo sapiens_hsa00650	1.03406029
39	Pyruvate metabolism_Homo sapiens_hsa00620	1.02260114
40	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.98318346
41	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.97393974
42	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.97085200
43	Cell cycle_Homo sapiens_hsa04110	0.96107107
44	Huntingtons disease_Homo sapiens_hsa05016	0.95879680
45	Oocyte meiosis_Homo sapiens_hsa04114	0.92043620
46	Collecting duct acid secretion_Homo sapiens_hsa04966	0.90771783
47	beta-Alanine metabolism_Homo sapiens_hsa00410	0.90312851
48	Base excision repair_Homo sapiens_hsa03410	0.90025781
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.89920243
50	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.89342251
51	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.87621164
52	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.87030530
53	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.81030094
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.79778190
55	Alcoholism_Homo sapiens_hsa05034	0.79762330
56	Tryptophan metabolism_Homo sapiens_hsa00380	0.76893260
57	Olfactory transduction_Homo sapiens_hsa04740	0.76638134
58	Insulin secretion_Homo sapiens_hsa04911	0.76569986
59	Type I diabetes mellitus_Homo sapiens_hsa04940	0.74893059
60	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.73815221
61	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.73232197
62	Purine metabolism_Homo sapiens_hsa00230	0.72095729
63	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.72016815
64	mRNA surveillance pathway_Homo sapiens_hsa03015	0.71108540
65	One carbon pool by folate_Homo sapiens_hsa00670	0.69396204
66	Retinol metabolism_Homo sapiens_hsa00830	0.69247784
67	Alzheimers disease_Homo sapiens_hsa05010	0.68910533
68	Fatty acid degradation_Homo sapiens_hsa00071	0.68019121
69	Linoleic acid metabolism_Homo sapiens_hsa00591	0.67336957
70	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.66141911
71	DNA replication_Homo sapiens_hsa03030	0.63953986
72	Amphetamine addiction_Homo sapiens_hsa05031	0.63638408
73	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.61875305
74	Fatty acid metabolism_Homo sapiens_hsa01212	0.60550235
75	Hippo signaling pathway_Homo sapiens_hsa04390	0.59698428
76	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.59395649
77	Nucleotide excision repair_Homo sapiens_hsa03420	0.58883023
78	Metabolic pathways_Homo sapiens_hsa01100	0.58241920
79	Ether lipid metabolism_Homo sapiens_hsa00565	0.56330471
80	Pyrimidine metabolism_Homo sapiens_hsa00240	0.55990248
81	p53 signaling pathway_Homo sapiens_hsa04115	0.55534740
82	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.53540722
83	Glutathione metabolism_Homo sapiens_hsa00480	0.52666527
84	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.49747980
85	Cardiac muscle contraction_Homo sapiens_hsa04260	0.49425400
86	Glycerolipid metabolism_Homo sapiens_hsa00561	0.47252955
87	Allograft rejection_Homo sapiens_hsa05330	0.46263215
88	Circadian rhythm_Homo sapiens_hsa04710	0.46086533
89	Histidine metabolism_Homo sapiens_hsa00340	0.45785889
90	Sphingolipid metabolism_Homo sapiens_hsa00600	0.44548195
91	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.39822641
92	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.39223218
93	Graft-versus-host disease_Homo sapiens_hsa05332	0.38221589
94	Circadian entrainment_Homo sapiens_hsa04713	0.37740269
95	Regulation of autophagy_Homo sapiens_hsa04140	0.36597460
96	GABAergic synapse_Homo sapiens_hsa04727	0.35878233
97	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.34834849
98	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.33891790
99	Morphine addiction_Homo sapiens_hsa05032	0.31357166
100	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.30887066

ZNF849P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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