ZNF850

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.71000530
2negative regulation of translation, ncRNA-mediated (GO:0040033)4.16478522
3regulation of translation, ncRNA-mediated (GO:0045974)4.16478522
4negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.16478522
5response to pheromone (GO:0019236)4.15963873
6negative regulation of DNA-dependent DNA replication (GO:2000104)4.13815289
7replication fork processing (GO:0031297)3.91496627
8fucose catabolic process (GO:0019317)3.88457700
9L-fucose metabolic process (GO:0042354)3.88457700
10L-fucose catabolic process (GO:0042355)3.88457700
11regulation of gene silencing by RNA (GO:0060966)3.80286646
12regulation of posttranscriptional gene silencing (GO:0060147)3.80286646
13regulation of gene silencing by miRNA (GO:0060964)3.80286646
14meiotic chromosome segregation (GO:0045132)3.78243068
15DNA replication-dependent nucleosome organization (GO:0034723)3.75712463
16DNA replication-dependent nucleosome assembly (GO:0006335)3.75712463
17regulation of nuclear cell cycle DNA replication (GO:0033262)3.59985438
18DNA replication checkpoint (GO:0000076)3.46288777
19somatic hypermutation of immunoglobulin genes (GO:0016446)3.44646582
20somatic diversification of immune receptors via somatic mutation (GO:0002566)3.44646582
21DNA double-strand break processing (GO:0000729)3.42190917
22chromatin remodeling at centromere (GO:0031055)3.40447050
23DNA deamination (GO:0045006)3.39695073
24synapsis (GO:0007129)3.32817472
25recombinational repair (GO:0000725)3.25192809
26negative regulation of telomere maintenance (GO:0032205)3.24689133
27centriole replication (GO:0007099)3.24509356
28maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.23933732
29double-strand break repair via homologous recombination (GO:0000724)3.23344981
30regulation of mitotic spindle checkpoint (GO:1903504)3.19915439
31regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.19915439
32rRNA catabolic process (GO:0016075)3.19553192
33kidney morphogenesis (GO:0060993)3.19151039
34ncRNA catabolic process (GO:0034661)3.19099748
35RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.18033825
36regulation of hippo signaling (GO:0035330)3.12072420
37CENP-A containing nucleosome assembly (GO:0034080)3.11702074
38reciprocal DNA recombination (GO:0035825)3.10613896
39reciprocal meiotic recombination (GO:0007131)3.10613896
40regulation of centriole replication (GO:0046599)3.05960874
41regulation of mesoderm development (GO:2000380)3.01913755
42regulation of DNA endoreduplication (GO:0032875)2.98952373
43histone exchange (GO:0043486)2.95605866
44somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.89598347
45isotype switching (GO:0045190)2.89598347
46somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.89598347
47protein K6-linked ubiquitination (GO:0085020)2.89227204
48water-soluble vitamin biosynthetic process (GO:0042364)2.85994648
49negative regulation of transcription regulatory region DNA binding (GO:2000678)2.83550570
50histone-serine phosphorylation (GO:0035404)2.82266263
51regulation of telomere maintenance (GO:0032204)2.81234877
52neural tube formation (GO:0001841)2.79691094
53kynurenine metabolic process (GO:0070189)2.79175175
54detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.76966482
55resolution of meiotic recombination intermediates (GO:0000712)2.71946004
56indolalkylamine metabolic process (GO:0006586)2.71297335
57piRNA metabolic process (GO:0034587)2.69681840
58protein K11-linked deubiquitination (GO:0035871)2.67356187
59retinal cone cell development (GO:0046549)2.67184412
60exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.66292651
61nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.66133775
62somite rostral/caudal axis specification (GO:0032525)2.65289168
63regulation of centrosome cycle (GO:0046605)2.63995396
64protein prenylation (GO:0018342)2.62678275
65prenylation (GO:0097354)2.62678275
66regulation of meiosis I (GO:0060631)2.61533958
67epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.61464739
68indole-containing compound catabolic process (GO:0042436)2.60707916
69indolalkylamine catabolic process (GO:0046218)2.60707916
70tryptophan catabolic process (GO:0006569)2.60707916
71DNA methylation involved in gamete generation (GO:0043046)2.60274023
72protein-cofactor linkage (GO:0018065)2.56554122
73pseudouridine synthesis (GO:0001522)2.53207855
74somatic diversification of immunoglobulins (GO:0016445)2.52822474
75postreplication repair (GO:0006301)2.51980880
76centrosome organization (GO:0051297)2.50493766
77respiratory chain complex IV assembly (GO:0008535)2.49544871
78atrial cardiac muscle cell action potential (GO:0086014)2.48906357
79protein localization to kinetochore (GO:0034501)2.46017136
80sulfation (GO:0051923)2.43370769
81mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.43362307
82mitochondrial respiratory chain complex I assembly (GO:0032981)2.43362307
83NADH dehydrogenase complex assembly (GO:0010257)2.43362307
84regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.42221640
85DNA demethylation (GO:0080111)2.41895204
86DNA recombination (GO:0006310)2.41048934
87regulation of centrosome duplication (GO:0010824)2.39654875
88maturation of 5.8S rRNA (GO:0000460)2.39585128
89somatic recombination of immunoglobulin gene segments (GO:0016447)2.39373119
90DNA strand renaturation (GO:0000733)2.38419047
91microtubule organizing center organization (GO:0031023)2.37184508
92tryptophan metabolic process (GO:0006568)2.36882861
93protein polyglutamylation (GO:0018095)2.36821066
94DNA-dependent DNA replication (GO:0006261)2.36451199
95somite development (GO:0061053)2.36050329
96mitochondrial RNA metabolic process (GO:0000959)2.35857341
97detection of light stimulus involved in sensory perception (GO:0050962)2.35739708
98detection of light stimulus involved in visual perception (GO:0050908)2.35739708
99kinetochore organization (GO:0051383)2.34847693
100mitochondrial respiratory chain complex assembly (GO:0033108)2.34629542

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.18560144
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.25846191
3E2F7_22180533_ChIP-Seq_HELA_Human3.17493271
4VDR_22108803_ChIP-Seq_LS180_Human3.15879719
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.06612775
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.81728397
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.61032084
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.57482811
9EWS_26573619_Chip-Seq_HEK293_Human2.42569121
10GBX2_23144817_ChIP-Seq_PC3_Human2.42546894
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.38077705
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.37011510
13FUS_26573619_Chip-Seq_HEK293_Human2.30540945
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.30117840
15EZH2_22144423_ChIP-Seq_EOC_Human2.27288917
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.24360710
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.18123349
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.13382644
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07473109
20TAF15_26573619_Chip-Seq_HEK293_Human2.01163709
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.00340450
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.99988370
23P300_19829295_ChIP-Seq_ESCs_Human1.96174659
24IGF1R_20145208_ChIP-Seq_DFB_Human1.94729041
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91667306
26MYC_18940864_ChIP-ChIP_HL60_Human1.89146799
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.88704795
28POU5F1_16153702_ChIP-ChIP_HESCs_Human1.83344090
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81987461
30GABP_17652178_ChIP-ChIP_JURKAT_Human1.81495720
31IRF1_19129219_ChIP-ChIP_H3396_Human1.69298857
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66128005
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64748142
34ELK1_19687146_ChIP-ChIP_HELA_Human1.60893800
35ER_23166858_ChIP-Seq_MCF-7_Human1.55518023
36TP63_19390658_ChIP-ChIP_HaCaT_Human1.52500076
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50936741
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49425680
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49304461
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46522561
41POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.46522561
42MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46419194
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42886264
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40033521
45STAT3_23295773_ChIP-Seq_U87_Human1.38854795
46CBP_20019798_ChIP-Seq_JUKART_Human1.36802108
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36802108
48FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.35300003
49BCAT_22108803_ChIP-Seq_LS180_Human1.33824430
50TP53_22573176_ChIP-Seq_HFKS_Human1.32900230
51VDR_23849224_ChIP-Seq_CD4+_Human1.31786613
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.31160027
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30501781
54TCF4_23295773_ChIP-Seq_U87_Human1.29976049
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27255520
56SMAD4_21799915_ChIP-Seq_A2780_Human1.26899913
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26746040
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23963977
59SOX2_16153702_ChIP-ChIP_HESCs_Human1.20889605
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20265948
61NANOG_19829295_ChIP-Seq_ESCs_Human1.19996854
62SOX2_19829295_ChIP-Seq_ESCs_Human1.19996854
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19752022
64AR_25329375_ChIP-Seq_VCAP_Human1.19655516
65KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.18425604
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.18282383
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16970378
68FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16422123
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.16422123
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15244991
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12259645
72TCF4_22108803_ChIP-Seq_LS180_Human1.10061978
73RNF2_27304074_Chip-Seq_NSC_Mouse1.09859792
74KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09069216
75RUNX2_22187159_ChIP-Seq_PCA_Human1.09025522
76SMAD4_21741376_ChIP-Seq_EPCs_Human1.05853178
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04436897
78HOXB7_26014856_ChIP-Seq_BT474_Human1.04381040
79ETS1_20019798_ChIP-Seq_JURKAT_Human1.03947408
80CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.03437329
81FOXP3_21729870_ChIP-Seq_TREG_Human1.03330095
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.03288076
83E2F1_21310950_ChIP-Seq_MCF-7_Human1.03235591
84BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02733188
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02652441
86PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02327797
87CBX2_27304074_Chip-Seq_ESCs_Mouse1.01502172
88GATA3_21878914_ChIP-Seq_MCF-7_Human0.99136902
89FLI1_21867929_ChIP-Seq_TH2_Mouse0.98923111
90NANOG_16153702_ChIP-ChIP_HESCs_Human0.98414937
91FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95711000
92AR_20517297_ChIP-Seq_VCAP_Human0.95608253
93SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94239620
94NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.93561049
95OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92692362
96NFE2_27457419_Chip-Seq_LIVER_Mouse0.92691088
97AR_21572438_ChIP-Seq_LNCaP_Human0.91337478
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.89142029
99NCOR_22424771_ChIP-Seq_293T_Human0.88994914
100JUN_21703547_ChIP-Seq_K562_Human0.86830719

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.02077591
2MP0006292_abnormal_olfactory_placode3.20074388
3MP0002102_abnormal_ear_morphology2.69005202
4MP0003890_abnormal_embryonic-extraembry2.60476480
5MP0010094_abnormal_chromosome_stability2.59827846
6MP0008057_abnormal_DNA_replication2.50394788
7MP0008058_abnormal_DNA_repair2.37786826
8MP0003136_yellow_coat_color2.28387274
9MP0003693_abnormal_embryo_hatching2.26969703
10MP0003718_maternal_effect2.24014874
11MP0003195_calcinosis2.15815700
12MP0002938_white_spotting2.10993616
13MP0000569_abnormal_digit_pigmentation2.09940049
14MP0003646_muscle_fatigue1.95627426
15MP0005551_abnormal_eye_electrophysiolog1.93199954
16MP0006072_abnormal_retinal_apoptosis1.92507623
17MP0003787_abnormal_imprinting1.91569428
18MP0001293_anophthalmia1.76746237
19MP0004133_heterotaxia1.72293033
20MP0000631_abnormal_neuroendocrine_gland1.65909641
21MP0001485_abnormal_pinna_reflex1.62094129
22MP0004147_increased_porphyrin_level1.61979235
23MP0008872_abnormal_physiological_respon1.61309731
24MP0002736_abnormal_nociception_after1.60832172
25MP0001968_abnormal_touch/_nociception1.60386376
26MP0003937_abnormal_limbs/digits/tail_de1.57491615
27MP0004043_abnormal_pH_regulation1.55182730
28MP0005253_abnormal_eye_physiology1.51793428
29MP0009046_muscle_twitch1.50629531
30MP0002638_abnormal_pupillary_reflex1.50510240
31MP0003119_abnormal_digestive_system1.45466545
32MP0003111_abnormal_nucleus_morphology1.43732527
33MP0000427_abnormal_hair_cycle1.42029781
34MP0005645_abnormal_hypothalamus_physiol1.37921758
35MP0002837_dystrophic_cardiac_calcinosis1.34966829
36MP0000372_irregular_coat_pigmentation1.34915746
37MP0000383_abnormal_hair_follicle1.28282174
38MP0004742_abnormal_vestibular_system1.27301886
39MP0003567_abnormal_fetal_cardiomyocyte1.27192812
40MP0003077_abnormal_cell_cycle1.25622325
41MP0004142_abnormal_muscle_tone1.23643970
42MP0004885_abnormal_endolymph1.23215179
43MP0008007_abnormal_cellular_replicative1.20051704
44MP0005174_abnormal_tail_pigmentation1.20009935
45MP0002160_abnormal_reproductive_system1.19154963
46MP0003121_genomic_imprinting1.17523945
47MP0001929_abnormal_gametogenesis1.15238166
48MP0008995_early_reproductive_senescence1.14927341
49MP0009745_abnormal_behavioral_response1.14165975
50MP0006276_abnormal_autonomic_nervous1.12781964
51MP0005646_abnormal_pituitary_gland1.12344494
52MP0002210_abnormal_sex_determination1.11621183
53MP0000049_abnormal_middle_ear1.09369987
54MP0005389_reproductive_system_phenotype1.08830348
55MP0009697_abnormal_copulation1.07985979
56MP0002751_abnormal_autonomic_nervous1.07338266
57MP0001986_abnormal_taste_sensitivity1.07049027
58MP0004957_abnormal_blastocyst_morpholog1.05005472
59MP0002163_abnormal_gland_morphology1.03324759
60MP0001286_abnormal_eye_development1.03027476
61MP0002272_abnormal_nervous_system1.01896158
62MP0000647_abnormal_sebaceous_gland1.01476972
63MP0003786_premature_aging0.98936775
64MP0002254_reproductive_system_inflammat0.98856593
65MP0008875_abnormal_xenobiotic_pharmacok0.97860400
66MP0005195_abnormal_posterior_eye0.97415866
67MP0000653_abnormal_sex_gland0.97398588
68MP0008932_abnormal_embryonic_tissue0.96040632
69MP0002928_abnormal_bile_duct0.95634311
70MP0002653_abnormal_ependyma_morphology0.95161786
71MP0001919_abnormal_reproductive_system0.95001193
72MP0005391_vision/eye_phenotype0.93799511
73MP0001145_abnormal_male_reproductive0.93607052
74MP0003698_abnormal_male_reproductive0.93480218
75MP0001324_abnormal_eye_pigmentation0.92743717
76MP0005187_abnormal_penis_morphology0.92736011
77MP0002557_abnormal_social/conspecific_i0.91979126
78MP0002234_abnormal_pharynx_morphology0.91305434
79MP0001486_abnormal_startle_reflex0.90623255
80MP0001529_abnormal_vocalization0.87008561
81MP0001119_abnormal_female_reproductive0.86009329
82MP0010307_abnormal_tumor_latency0.85100999
83MP0008789_abnormal_olfactory_epithelium0.83969703
84MP0001984_abnormal_olfaction0.82775534
85MP0003880_abnormal_central_pattern0.81816986
86MP0004145_abnormal_muscle_electrophysio0.81290922
87MP0001501_abnormal_sleep_pattern0.81027950
88MP0002735_abnormal_chemical_nociception0.80114686
89MP0004215_abnormal_myocardial_fiber0.78392535
90MP0002095_abnormal_skin_pigmentation0.78178311
91MP0000778_abnormal_nervous_system0.77761089
92MP0002233_abnormal_nose_morphology0.77540131
93MP0005084_abnormal_gallbladder_morpholo0.77239837
94MP0003283_abnormal_digestive_organ0.76894380
95MP0005410_abnormal_fertilization0.76690542
96MP0002876_abnormal_thyroid_physiology0.76011284
97MP0003011_delayed_dark_adaptation0.75872238
98MP0005377_hearing/vestibular/ear_phenot0.74674872
99MP0003878_abnormal_ear_physiology0.74674872
100MP0003943_abnormal_hepatobiliary_system0.74670654

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.99776403
2Birth length less than 3rd percentile (HP:0003561)3.77161243
3Pancreatic fibrosis (HP:0100732)3.68961094
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.59428396
5Molar tooth sign on MRI (HP:0002419)3.53303065
6Abnormality of midbrain morphology (HP:0002418)3.53303065
7True hermaphroditism (HP:0010459)3.46094113
8Chromsome breakage (HP:0040012)3.42808593
9Congenital stationary night blindness (HP:0007642)3.27174346
10Abnormality of the labia minora (HP:0012880)3.22550927
11Aplasia/Hypoplasia of the uvula (HP:0010293)3.17156805
12Nephronophthisis (HP:0000090)3.02599574
13Colon cancer (HP:0003003)2.96061011
14Meckel diverticulum (HP:0002245)2.95600055
15Abnormality of the ileum (HP:0001549)2.93543591
16Abnormality of chromosome stability (HP:0003220)2.78808298
17Type II lissencephaly (HP:0007260)2.75599090
18Hyperalaninemia (HP:0003348)2.70652685
19Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.70652685
20Abnormality of alanine metabolism (HP:0010916)2.70652685
21Abnormality of the renal cortex (HP:0011035)2.66575305
22Abnormality of the renal medulla (HP:0100957)2.65776317
23Cystic liver disease (HP:0006706)2.60271897
24Pendular nystagmus (HP:0012043)2.58177552
25Attenuation of retinal blood vessels (HP:0007843)2.53743916
26Patellar aplasia (HP:0006443)2.49944641
27Cerebellar dysplasia (HP:0007033)2.43060397
28Abnormality of the pons (HP:0007361)2.41769731
29Chronic hepatic failure (HP:0100626)2.41107973
30Abnormality of the preputium (HP:0100587)2.37374383
31Tubular atrophy (HP:0000092)2.36741131
32Progressive inability to walk (HP:0002505)2.34659192
33Aplasia/Hypoplasia of the patella (HP:0006498)2.33949751
34Sloping forehead (HP:0000340)2.32053310
35Abnormality of the carotid arteries (HP:0005344)2.31970961
36Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.29115644
37Protruding tongue (HP:0010808)2.28989634
38Hypoplasia of the pons (HP:0012110)2.28173641
39Ectopic kidney (HP:0000086)2.27218919
40Inability to walk (HP:0002540)2.26893763
41Clubbing of toes (HP:0100760)2.25563423
42Sclerocornea (HP:0000647)2.24385175
43Hyperventilation (HP:0002883)2.22276146
44Abolished electroretinogram (ERG) (HP:0000550)2.19779120
45Anencephaly (HP:0002323)2.15828253
46Optic nerve hypoplasia (HP:0000609)2.15400745
47Lissencephaly (HP:0001339)2.14139358
48Duplicated collecting system (HP:0000081)2.13231379
49Duodenal stenosis (HP:0100867)2.13037239
50Small intestinal stenosis (HP:0012848)2.13037239
51Bilateral microphthalmos (HP:0007633)2.12820144
52Triphalangeal thumb (HP:0001199)2.09654840
53Aplasia/Hypoplasia of the tibia (HP:0005772)2.08269256
54Medial flaring of the eyebrow (HP:0010747)2.07616410
55Partial agenesis of the corpus callosum (HP:0001338)2.06037528
56Abnormality of the renal collecting system (HP:0004742)2.05964954
57Gaze-evoked nystagmus (HP:0000640)2.03846432
58Aplasia/Hypoplasia of the tongue (HP:0010295)2.03323641
59Supernumerary spleens (HP:0009799)2.03304278
60Bile duct proliferation (HP:0001408)2.02980685
61Abnormal biliary tract physiology (HP:0012439)2.02980685
62Dandy-Walker malformation (HP:0001305)2.02171534
63Abnormality of the duodenum (HP:0002246)2.01086260
64Absent thumb (HP:0009777)1.99519534
65Septo-optic dysplasia (HP:0100842)1.97500383
66Aplasia/Hypoplasia of the sternum (HP:0006714)1.97080695
67Neoplasm of the adrenal cortex (HP:0100641)1.95209852
68Oligodactyly (hands) (HP:0001180)1.94414909
69Preaxial hand polydactyly (HP:0001177)1.91428901
70Methylmalonic acidemia (HP:0002912)1.89768574
71Volvulus (HP:0002580)1.88980317
72Small hand (HP:0200055)1.87347200
73Intestinal atresia (HP:0011100)1.87247064
74Breast hypoplasia (HP:0003187)1.85459906
75Genetic anticipation (HP:0003743)1.84123889
76Abnormal drinking behavior (HP:0030082)1.81454450
77Polydipsia (HP:0001959)1.81454450
78Renal cortical cysts (HP:0000803)1.79789993
79Anophthalmia (HP:0000528)1.79304922
80Glioma (HP:0009733)1.78080066
81Absent radius (HP:0003974)1.76211084
82Furrowed tongue (HP:0000221)1.76181882
83Congenital hepatic fibrosis (HP:0002612)1.75878123
84Oligohydramnios (HP:0001562)1.75718788
85Postaxial foot polydactyly (HP:0001830)1.75308965
86Progressive cerebellar ataxia (HP:0002073)1.74920530
87Abnormal rod and cone electroretinograms (HP:0008323)1.74406066
88Abnormality of DNA repair (HP:0003254)1.73756535
89Aplasia involving forearm bones (HP:0009822)1.73327400
90Absent forearm bone (HP:0003953)1.73327400
91Broad-based gait (HP:0002136)1.72014208
92Chorioretinal atrophy (HP:0000533)1.71297877
93Fair hair (HP:0002286)1.70862153
94Genital tract atresia (HP:0001827)1.69393887
95Dynein arm defect of respiratory motile cilia (HP:0012255)1.67981128
96Absent/shortened dynein arms (HP:0200106)1.67981128
97Male pseudohermaphroditism (HP:0000037)1.67754970
98Hyperglycinemia (HP:0002154)1.66973067
99Decreased central vision (HP:0007663)1.66783804
100Astigmatism (HP:0000483)1.66423440

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK4.32601938
2FRK4.31272300
3BMPR1B3.14150613
4ACVR1B3.06220071
5MKNK22.66450384
6TLK12.52178602
7WNK32.50942387
8NUAK12.50578203
9BRSK22.43296016
10ADRBK22.32720222
11TNIK2.31390230
12CDC72.07553950
13WNK42.01300208
14WEE11.88687734
15CASK1.87804323
16PLK41.81632995
17TTK1.76522075
18GRK11.75709261
19TSSK61.75028043
20MKNK11.69739421
21BUB11.61182700
22MAP4K21.57246261
23PLK31.56976821
24INSRR1.54453615
25VRK11.50915016
26PNCK1.44334056
27TGFBR11.37277349
28OXSR11.25786525
29TRIM281.18827606
30PLK11.18240918
31PINK11.17633745
32TAOK31.15270107
33CHEK21.14938773
34MAPK131.14749306
35TAF11.11634909
36STK38L1.09853469
37DAPK21.07962229
38NEK21.06780061
39STK31.05958299
40SRPK11.03718223
41MAP3K41.02709862
42ATR0.99080106
43STK390.91383661
44CAMK1D0.90371481
45TXK0.90201229
46NLK0.88448524
47TIE10.87979867
48CAMK1G0.84690724
49ADRBK10.82835321
50DYRK20.80383838
51PBK0.77918583
52MELK0.73085444
53BRSK10.71007103
54ATM0.70634510
55TEC0.69449979
56PRKCG0.68193594
57LATS10.63033433
58RPS6KA50.61863914
59FGFR20.61175425
60NEK10.61018968
61CSNK1G10.60988155
62IRAK10.60601383
63MST40.60203266
64PLK20.58117607
65EIF2AK30.56989492
66PAK30.56336151
67PKN10.55809675
68PRKCE0.54791116
69MAPKAPK50.54340446
70AURKB0.51057888
71EIF2AK20.44564686
72FLT30.44559792
73PASK0.44135775
74VRK20.43531174
75CHEK10.42872371
76DYRK30.41857694
77PIK3CA0.40299484
78NME10.39504372
79CSNK1G20.39371119
80STK110.38447699
81EPHA40.37791508
82CDK30.36045028
83CDK10.35825012
84PIM10.35698029
85PRKAA10.34828137
86ERBB40.34824356
87PRKCI0.33203090
88AKT30.31650828
89CSNK1G30.31073901
90CSNK1D0.30884198
91STK40.30866832
92WNK10.30342163
93CAMKK20.28942733
94BRD40.28790295
95MAP2K70.28122261
96CSNK1A1L0.27449219
97PRKDC0.27107544
98SGK20.27054244
99CSNK1E0.26801428
100PRKCQ0.26678831

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034403.36250269
2Fanconi anemia pathway_Homo sapiens_hsa034603.06374147
3Selenocompound metabolism_Homo sapiens_hsa004502.66978171
4Basal transcription factors_Homo sapiens_hsa030222.60825636
5RNA polymerase_Homo sapiens_hsa030202.42876311
6Non-homologous end-joining_Homo sapiens_hsa034502.41947155
7Phototransduction_Homo sapiens_hsa047442.36954054
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.23551568
9Linoleic acid metabolism_Homo sapiens_hsa005912.15232024
10Mismatch repair_Homo sapiens_hsa034302.13839669
11Nitrogen metabolism_Homo sapiens_hsa009102.11123124
12One carbon pool by folate_Homo sapiens_hsa006702.05318269
13RNA degradation_Homo sapiens_hsa030182.00698999
14Caffeine metabolism_Homo sapiens_hsa002321.90882401
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.89674672
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.85158803
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.78880028
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.75010917
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70057054
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.69416607
21DNA replication_Homo sapiens_hsa030301.68357758
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.65022477
23Butanoate metabolism_Homo sapiens_hsa006501.64483668
24Nicotine addiction_Homo sapiens_hsa050331.61086032
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.60210601
26Protein export_Homo sapiens_hsa030601.49874552
27RNA transport_Homo sapiens_hsa030131.48344175
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.48041265
29Nucleotide excision repair_Homo sapiens_hsa034201.46658729
30Propanoate metabolism_Homo sapiens_hsa006401.45186782
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.44715304
32Tryptophan metabolism_Homo sapiens_hsa003801.41499223
33Ether lipid metabolism_Homo sapiens_hsa005651.37681182
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.36291596
35Cell cycle_Homo sapiens_hsa041101.35349870
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32267131
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.24846223
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.16018417
39Oxidative phosphorylation_Homo sapiens_hsa001901.15146909
40Taste transduction_Homo sapiens_hsa047421.11429861
41Olfactory transduction_Homo sapiens_hsa047401.10706578
42Pyrimidine metabolism_Homo sapiens_hsa002401.03019143
43Purine metabolism_Homo sapiens_hsa002301.02523809
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00745444
45Systemic lupus erythematosus_Homo sapiens_hsa053220.99662814
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94254391
47Parkinsons disease_Homo sapiens_hsa050120.92510192
48Lysine degradation_Homo sapiens_hsa003100.92422803
49Huntingtons disease_Homo sapiens_hsa050160.88805721
50Base excision repair_Homo sapiens_hsa034100.87804416
51p53 signaling pathway_Homo sapiens_hsa041150.87530600
52Spliceosome_Homo sapiens_hsa030400.81986865
53ABC transporters_Homo sapiens_hsa020100.79008747
54Proteasome_Homo sapiens_hsa030500.77386103
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76512080
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76429560
57Basal cell carcinoma_Homo sapiens_hsa052170.75806021
58Morphine addiction_Homo sapiens_hsa050320.75070471
59Retinol metabolism_Homo sapiens_hsa008300.74710574
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71551480
61Hedgehog signaling pathway_Homo sapiens_hsa043400.70341800
62Serotonergic synapse_Homo sapiens_hsa047260.69309991
63Glycerolipid metabolism_Homo sapiens_hsa005610.68834131
64TGF-beta signaling pathway_Homo sapiens_hsa043500.68545450
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.67487374
66Alcoholism_Homo sapiens_hsa050340.66904631
67Ovarian steroidogenesis_Homo sapiens_hsa049130.66504456
68Peroxisome_Homo sapiens_hsa041460.66000485
69Steroid biosynthesis_Homo sapiens_hsa001000.64200740
70Regulation of autophagy_Homo sapiens_hsa041400.64019658
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.62644527
72Arachidonic acid metabolism_Homo sapiens_hsa005900.62415388
73Ribosome_Homo sapiens_hsa030100.61113604
74Chemical carcinogenesis_Homo sapiens_hsa052040.60715660
75beta-Alanine metabolism_Homo sapiens_hsa004100.59561480
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.58213774
77Cardiac muscle contraction_Homo sapiens_hsa042600.57477483
78mRNA surveillance pathway_Homo sapiens_hsa030150.54820507
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54086917
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52870778
81Insulin secretion_Homo sapiens_hsa049110.52586947
82Hippo signaling pathway_Homo sapiens_hsa043900.52210764
83Glutamatergic synapse_Homo sapiens_hsa047240.52108198
84Metabolic pathways_Homo sapiens_hsa011000.52070383
85Vitamin digestion and absorption_Homo sapiens_hsa049770.51170788
86GABAergic synapse_Homo sapiens_hsa047270.47817755
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47608665
88Sulfur relay system_Homo sapiens_hsa041220.46768275
89Circadian entrainment_Homo sapiens_hsa047130.45479785
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45286110
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43525456
92Calcium signaling pathway_Homo sapiens_hsa040200.43049043
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.43006814
94Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42179143
95Alzheimers disease_Homo sapiens_hsa050100.39746451
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39315481
97Long-term depression_Homo sapiens_hsa047300.39213377
98Primary immunodeficiency_Homo sapiens_hsa053400.38628953
99Histidine metabolism_Homo sapiens_hsa003400.38493504
100Oocyte meiosis_Homo sapiens_hsa041140.35535610

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