ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.71000530
2	negative regulation of translation, ncRNA-mediated (GO:0040033)	4.16478522
3	regulation of translation, ncRNA-mediated (GO:0045974)	4.16478522
4	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	4.16478522
5	response to pheromone (GO:0019236)	4.15963873
6	negative regulation of DNA-dependent DNA replication (GO:2000104)	4.13815289
7	replication fork processing (GO:0031297)	3.91496627
8	fucose catabolic process (GO:0019317)	3.88457700
9	L-fucose metabolic process (GO:0042354)	3.88457700
10	L-fucose catabolic process (GO:0042355)	3.88457700
11	regulation of gene silencing by RNA (GO:0060966)	3.80286646
12	regulation of posttranscriptional gene silencing (GO:0060147)	3.80286646
13	regulation of gene silencing by miRNA (GO:0060964)	3.80286646
14	meiotic chromosome segregation (GO:0045132)	3.78243068
15	DNA replication-dependent nucleosome assembly (GO:0006335)	3.75712463
16	DNA replication-dependent nucleosome organization (GO:0034723)	3.75712463
17	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.59985438
18	DNA replication checkpoint (GO:0000076)	3.46288777
19	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.44646582
20	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.44646582
21	DNA double-strand break processing (GO:0000729)	3.42190917
22	chromatin remodeling at centromere (GO:0031055)	3.40447050
23	DNA deamination (GO:0045006)	3.39695073
24	synapsis (GO:0007129)	3.32817472
25	recombinational repair (GO:0000725)	3.25192809
26	negative regulation of telomere maintenance (GO:0032205)	3.24689133
27	centriole replication (GO:0007099)	3.24509356
28	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.23933732
29	double-strand break repair via homologous recombination (GO:0000724)	3.23344981
30	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.19915439
31	regulation of mitotic spindle checkpoint (GO:1903504)	3.19915439
32	rRNA catabolic process (GO:0016075)	3.19553192
33	kidney morphogenesis (GO:0060993)	3.19151039
34	ncRNA catabolic process (GO:0034661)	3.19099748
35	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.18033825
36	regulation of hippo signaling (GO:0035330)	3.12072420
37	CENP-A containing nucleosome assembly (GO:0034080)	3.11702074
38	reciprocal DNA recombination (GO:0035825)	3.10613896
39	reciprocal meiotic recombination (GO:0007131)	3.10613896
40	regulation of centriole replication (GO:0046599)	3.05960874
41	regulation of mesoderm development (GO:2000380)	3.01913755
42	regulation of DNA endoreduplication (GO:0032875)	2.98952373
43	histone exchange (GO:0043486)	2.95605866
44	isotype switching (GO:0045190)	2.89598347
45	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.89598347
46	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.89598347
47	protein K6-linked ubiquitination (GO:0085020)	2.89227204
48	water-soluble vitamin biosynthetic process (GO:0042364)	2.85994648
49	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.83550570
50	histone-serine phosphorylation (GO:0035404)	2.82266263
51	regulation of telomere maintenance (GO:0032204)	2.81234877
52	neural tube formation (GO:0001841)	2.79691094
53	kynurenine metabolic process (GO:0070189)	2.79175175
54	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.76966482
55	resolution of meiotic recombination intermediates (GO:0000712)	2.71946004
56	indolalkylamine metabolic process (GO:0006586)	2.71297335
57	piRNA metabolic process (GO:0034587)	2.69681840
58	protein K11-linked deubiquitination (GO:0035871)	2.67356187
59	retinal cone cell development (GO:0046549)	2.67184412
60	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.66292651
61	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.66133775
62	somite rostral/caudal axis specification (GO:0032525)	2.65289168
63	regulation of centrosome cycle (GO:0046605)	2.63995396
64	prenylation (GO:0097354)	2.62678275
65	protein prenylation (GO:0018342)	2.62678275
66	regulation of meiosis I (GO:0060631)	2.61533958
67	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.61464739
68	indole-containing compound catabolic process (GO:0042436)	2.60707916
69	indolalkylamine catabolic process (GO:0046218)	2.60707916
70	tryptophan catabolic process (GO:0006569)	2.60707916
71	DNA methylation involved in gamete generation (GO:0043046)	2.60274023
72	protein-cofactor linkage (GO:0018065)	2.56554122
73	pseudouridine synthesis (GO:0001522)	2.53207855
74	somatic diversification of immunoglobulins (GO:0016445)	2.52822474
75	postreplication repair (GO:0006301)	2.51980880
76	centrosome organization (GO:0051297)	2.50493766
77	respiratory chain complex IV assembly (GO:0008535)	2.49544871
78	atrial cardiac muscle cell action potential (GO:0086014)	2.48906357
79	protein localization to kinetochore (GO:0034501)	2.46017136
80	sulfation (GO:0051923)	2.43370769
81	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.43362307
82	NADH dehydrogenase complex assembly (GO:0010257)	2.43362307
83	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.43362307
84	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.42221640
85	DNA demethylation (GO:0080111)	2.41895204
86	DNA recombination (GO:0006310)	2.41048934
87	regulation of centrosome duplication (GO:0010824)	2.39654875
88	maturation of 5.8S rRNA (GO:0000460)	2.39585128
89	somatic recombination of immunoglobulin gene segments (GO:0016447)	2.39373119
90	DNA strand renaturation (GO:0000733)	2.38419047
91	microtubule organizing center organization (GO:0031023)	2.37184508
92	tryptophan metabolic process (GO:0006568)	2.36882861
93	protein polyglutamylation (GO:0018095)	2.36821066
94	DNA-dependent DNA replication (GO:0006261)	2.36451199
95	somite development (GO:0061053)	2.36050329
96	mitochondrial RNA metabolic process (GO:0000959)	2.35857341
97	detection of light stimulus involved in visual perception (GO:0050908)	2.35739708
98	detection of light stimulus involved in sensory perception (GO:0050962)	2.35739708
99	kinetochore organization (GO:0051383)	2.34847693
100	mitochondrial respiratory chain complex assembly (GO:0033108)	2.34629542

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.18560144
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.25846191
3	E2F7_22180533_ChIP-Seq_HELA_Human	3.17493271
4	VDR_22108803_ChIP-Seq_LS180_Human	3.15879719
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.06612775
6	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.81728397
7	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.61032084
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.57482811
9	EWS_26573619_Chip-Seq_HEK293_Human	2.42569121
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.42546894
11	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.38077705
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.37011510
13	FUS_26573619_Chip-Seq_HEK293_Human	2.30540945
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.30117840
15	EZH2_22144423_ChIP-Seq_EOC_Human	2.27288917
16	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.24360710
17	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.18123349
18	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.13382644
19	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.07473109
20	TAF15_26573619_Chip-Seq_HEK293_Human	2.01163709
21	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.00340450
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.99988370
23	P300_19829295_ChIP-Seq_ESCs_Human	1.96174659
24	IGF1R_20145208_ChIP-Seq_DFB_Human	1.94729041
25	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.91667306
26	MYC_18940864_ChIP-ChIP_HL60_Human	1.89146799
27	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.88704795
28	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.83344090
29	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.81987461
30	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.81495720
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.69298857
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.66128005
33	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.64748142
34	ELK1_19687146_ChIP-ChIP_HELA_Human	1.60893800
35	ER_23166858_ChIP-Seq_MCF-7_Human	1.55518023
36	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.52500076
37	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.50936741
38	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.49425680
39	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.49304461
40	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.46522561
41	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.46522561
42	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.46419194
43	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.42886264
44	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.40033521
45	STAT3_23295773_ChIP-Seq_U87_Human	1.38854795
46	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.36802108
47	CBP_20019798_ChIP-Seq_JUKART_Human	1.36802108
48	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.35300003
49	BCAT_22108803_ChIP-Seq_LS180_Human	1.33824430
50	TP53_22573176_ChIP-Seq_HFKS_Human	1.32900230
51	VDR_23849224_ChIP-Seq_CD4+_Human	1.31786613
52	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.31160027
53	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.30501781
54	TCF4_23295773_ChIP-Seq_U87_Human	1.29976049
55	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.27255520
56	SMAD4_21799915_ChIP-Seq_A2780_Human	1.26899913
57	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.26746040
58	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.23963977
59	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.20889605
60	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.20265948
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.19996854
62	NANOG_19829295_ChIP-Seq_ESCs_Human	1.19996854
63	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.19752022
64	AR_25329375_ChIP-Seq_VCAP_Human	1.19655516
65	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.18425604
66	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.18282383
67	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.16970378
68	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.16422123
69	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.16422123
70	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.15244991
71	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.12259645
72	TCF4_22108803_ChIP-Seq_LS180_Human	1.10061978
73	RNF2_27304074_Chip-Seq_NSC_Mouse	1.09859792
74	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.09069216
75	RUNX2_22187159_ChIP-Seq_PCA_Human	1.09025522
76	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.05853178
77	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.04436897
78	HOXB7_26014856_ChIP-Seq_BT474_Human	1.04381040
79	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.03947408
80	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.03437329
81	FOXP3_21729870_ChIP-Seq_TREG_Human	1.03330095
82	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.03288076
83	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.03235591
84	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.02733188
85	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.02652441
86	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.02327797
87	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.01502172
88	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.99136902
89	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.98923111
90	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.98414937
91	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.95711000
92	AR_20517297_ChIP-Seq_VCAP_Human	0.95608253
93	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.94239620
94	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.93561049
95	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.92692362
96	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.92691088
97	AR_21572438_ChIP-Seq_LNCaP_Human	0.91337478
98	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.89142029
99	NCOR_22424771_ChIP-Seq_293T_Human	0.88994914
100	JUN_21703547_ChIP-Seq_K562_Human	0.86830719

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	4.02077591
2	MP0006292_abnormal_olfactory_placode	3.20074388
3	MP0002102_abnormal_ear_morphology	2.69005202
4	MP0003890_abnormal_embryonic-extraembry	2.60476480
5	MP0010094_abnormal_chromosome_stability	2.59827846
6	MP0008057_abnormal_DNA_replication	2.50394788
7	MP0008058_abnormal_DNA_repair	2.37786826
8	MP0003136_yellow_coat_color	2.28387274
9	MP0003693_abnormal_embryo_hatching	2.26969703
10	MP0003718_maternal_effect	2.24014874
11	MP0003195_calcinosis	2.15815700
12	MP0002938_white_spotting	2.10993616
13	MP0000569_abnormal_digit_pigmentation	2.09940049
14	MP0003646_muscle_fatigue	1.95627426
15	MP0005551_abnormal_eye_electrophysiolog	1.93199954
16	MP0006072_abnormal_retinal_apoptosis	1.92507623
17	MP0003787_abnormal_imprinting	1.91569428
18	MP0001293_anophthalmia	1.76746237
19	MP0004133_heterotaxia	1.72293033
20	MP0000631_abnormal_neuroendocrine_gland	1.65909641
21	MP0001485_abnormal_pinna_reflex	1.62094129
22	MP0004147_increased_porphyrin_level	1.61979235
23	MP0008872_abnormal_physiological_respon	1.61309731
24	MP0002736_abnormal_nociception_after	1.60832172
25	MP0001968_abnormal_touch/_nociception	1.60386376
26	MP0003937_abnormal_limbs/digits/tail_de	1.57491615
27	MP0004043_abnormal_pH_regulation	1.55182730
28	MP0005253_abnormal_eye_physiology	1.51793428
29	MP0009046_muscle_twitch	1.50629531
30	MP0002638_abnormal_pupillary_reflex	1.50510240
31	MP0003119_abnormal_digestive_system	1.45466545
32	MP0003111_abnormal_nucleus_morphology	1.43732527
33	MP0000427_abnormal_hair_cycle	1.42029781
34	MP0005645_abnormal_hypothalamus_physiol	1.37921758
35	MP0002837_dystrophic_cardiac_calcinosis	1.34966829
36	MP0000372_irregular_coat_pigmentation	1.34915746
37	MP0000383_abnormal_hair_follicle	1.28282174
38	MP0004742_abnormal_vestibular_system	1.27301886
39	MP0003567_abnormal_fetal_cardiomyocyte	1.27192812
40	MP0003077_abnormal_cell_cycle	1.25622325
41	MP0004142_abnormal_muscle_tone	1.23643970
42	MP0004885_abnormal_endolymph	1.23215179
43	MP0008007_abnormal_cellular_replicative	1.20051704
44	MP0005174_abnormal_tail_pigmentation	1.20009935
45	MP0002160_abnormal_reproductive_system	1.19154963
46	MP0003121_genomic_imprinting	1.17523945
47	MP0001929_abnormal_gametogenesis	1.15238166
48	MP0008995_early_reproductive_senescence	1.14927341
49	MP0009745_abnormal_behavioral_response	1.14165975
50	MP0006276_abnormal_autonomic_nervous	1.12781964
51	MP0005646_abnormal_pituitary_gland	1.12344494
52	MP0002210_abnormal_sex_determination	1.11621183
53	MP0000049_abnormal_middle_ear	1.09369987
54	MP0005389_reproductive_system_phenotype	1.08830348
55	MP0009697_abnormal_copulation	1.07985979
56	MP0002751_abnormal_autonomic_nervous	1.07338266
57	MP0001986_abnormal_taste_sensitivity	1.07049027
58	MP0004957_abnormal_blastocyst_morpholog	1.05005472
59	MP0002163_abnormal_gland_morphology	1.03324759
60	MP0001286_abnormal_eye_development	1.03027476
61	MP0002272_abnormal_nervous_system	1.01896158
62	MP0000647_abnormal_sebaceous_gland	1.01476972
63	MP0003786_premature_aging	0.98936775
64	MP0002254_reproductive_system_inflammat	0.98856593
65	MP0008875_abnormal_xenobiotic_pharmacok	0.97860400
66	MP0005195_abnormal_posterior_eye	0.97415866
67	MP0000653_abnormal_sex_gland	0.97398588
68	MP0008932_abnormal_embryonic_tissue	0.96040632
69	MP0002928_abnormal_bile_duct	0.95634311
70	MP0002653_abnormal_ependyma_morphology	0.95161786
71	MP0001919_abnormal_reproductive_system	0.95001193
72	MP0005391_vision/eye_phenotype	0.93799511
73	MP0001145_abnormal_male_reproductive	0.93607052
74	MP0003698_abnormal_male_reproductive	0.93480218
75	MP0001324_abnormal_eye_pigmentation	0.92743717
76	MP0005187_abnormal_penis_morphology	0.92736011
77	MP0002557_abnormal_social/conspecific_i	0.91979126
78	MP0002234_abnormal_pharynx_morphology	0.91305434
79	MP0001486_abnormal_startle_reflex	0.90623255
80	MP0001529_abnormal_vocalization	0.87008561
81	MP0001119_abnormal_female_reproductive	0.86009329
82	MP0010307_abnormal_tumor_latency	0.85100999
83	MP0008789_abnormal_olfactory_epithelium	0.83969703
84	MP0001984_abnormal_olfaction	0.82775534
85	MP0003880_abnormal_central_pattern	0.81816986
86	MP0004145_abnormal_muscle_electrophysio	0.81290922
87	MP0001501_abnormal_sleep_pattern	0.81027950
88	MP0002735_abnormal_chemical_nociception	0.80114686
89	MP0004215_abnormal_myocardial_fiber	0.78392535
90	MP0002095_abnormal_skin_pigmentation	0.78178311
91	MP0000778_abnormal_nervous_system	0.77761089
92	MP0002233_abnormal_nose_morphology	0.77540131
93	MP0005084_abnormal_gallbladder_morpholo	0.77239837
94	MP0003283_abnormal_digestive_organ	0.76894380
95	MP0005410_abnormal_fertilization	0.76690542
96	MP0002876_abnormal_thyroid_physiology	0.76011284
97	MP0003011_delayed_dark_adaptation	0.75872238
98	MP0005377_hearing/vestibular/ear_phenot	0.74674872
99	MP0003878_abnormal_ear_physiology	0.74674872
100	MP0003943_abnormal_hepatobiliary_system	0.74670654

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.99776403
2	Birth length less than 3rd percentile (HP:0003561)	3.77161243
3	Pancreatic fibrosis (HP:0100732)	3.68961094
4	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.59428396
5	Molar tooth sign on MRI (HP:0002419)	3.53303065
6	Abnormality of midbrain morphology (HP:0002418)	3.53303065
7	True hermaphroditism (HP:0010459)	3.46094113
8	Chromsome breakage (HP:0040012)	3.42808593
9	Congenital stationary night blindness (HP:0007642)	3.27174346
10	Abnormality of the labia minora (HP:0012880)	3.22550927
11	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.17156805
12	Nephronophthisis (HP:0000090)	3.02599574
13	Colon cancer (HP:0003003)	2.96061011
14	Meckel diverticulum (HP:0002245)	2.95600055
15	Abnormality of the ileum (HP:0001549)	2.93543591
16	Abnormality of chromosome stability (HP:0003220)	2.78808298
17	Type II lissencephaly (HP:0007260)	2.75599090
18	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.70652685
19	Abnormality of alanine metabolism (HP:0010916)	2.70652685
20	Hyperalaninemia (HP:0003348)	2.70652685
21	Abnormality of the renal cortex (HP:0011035)	2.66575305
22	Abnormality of the renal medulla (HP:0100957)	2.65776317
23	Cystic liver disease (HP:0006706)	2.60271897
24	Pendular nystagmus (HP:0012043)	2.58177552
25	Attenuation of retinal blood vessels (HP:0007843)	2.53743916
26	Patellar aplasia (HP:0006443)	2.49944641
27	Cerebellar dysplasia (HP:0007033)	2.43060397
28	Abnormality of the pons (HP:0007361)	2.41769731
29	Chronic hepatic failure (HP:0100626)	2.41107973
30	Abnormality of the preputium (HP:0100587)	2.37374383
31	Tubular atrophy (HP:0000092)	2.36741131
32	Progressive inability to walk (HP:0002505)	2.34659192
33	Aplasia/Hypoplasia of the patella (HP:0006498)	2.33949751
34	Sloping forehead (HP:0000340)	2.32053310
35	Abnormality of the carotid arteries (HP:0005344)	2.31970961
36	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.29115644
37	Protruding tongue (HP:0010808)	2.28989634
38	Hypoplasia of the pons (HP:0012110)	2.28173641
39	Ectopic kidney (HP:0000086)	2.27218919
40	Inability to walk (HP:0002540)	2.26893763
41	Clubbing of toes (HP:0100760)	2.25563423
42	Sclerocornea (HP:0000647)	2.24385175
43	Hyperventilation (HP:0002883)	2.22276146
44	Abolished electroretinogram (ERG) (HP:0000550)	2.19779120
45	Anencephaly (HP:0002323)	2.15828253
46	Optic nerve hypoplasia (HP:0000609)	2.15400745
47	Lissencephaly (HP:0001339)	2.14139358
48	Duplicated collecting system (HP:0000081)	2.13231379
49	Small intestinal stenosis (HP:0012848)	2.13037239
50	Duodenal stenosis (HP:0100867)	2.13037239
51	Bilateral microphthalmos (HP:0007633)	2.12820144
52	Triphalangeal thumb (HP:0001199)	2.09654840
53	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.08269256
54	Medial flaring of the eyebrow (HP:0010747)	2.07616410
55	Partial agenesis of the corpus callosum (HP:0001338)	2.06037528
56	Abnormality of the renal collecting system (HP:0004742)	2.05964954
57	Gaze-evoked nystagmus (HP:0000640)	2.03846432
58	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.03323641
59	Supernumerary spleens (HP:0009799)	2.03304278
60	Abnormal biliary tract physiology (HP:0012439)	2.02980685
61	Bile duct proliferation (HP:0001408)	2.02980685
62	Dandy-Walker malformation (HP:0001305)	2.02171534
63	Abnormality of the duodenum (HP:0002246)	2.01086260
64	Absent thumb (HP:0009777)	1.99519534
65	Septo-optic dysplasia (HP:0100842)	1.97500383
66	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.97080695
67	Neoplasm of the adrenal cortex (HP:0100641)	1.95209852
68	Oligodactyly (hands) (HP:0001180)	1.94414909
69	Preaxial hand polydactyly (HP:0001177)	1.91428901
70	Methylmalonic acidemia (HP:0002912)	1.89768574
71	Volvulus (HP:0002580)	1.88980317
72	Small hand (HP:0200055)	1.87347200
73	Intestinal atresia (HP:0011100)	1.87247064
74	Breast hypoplasia (HP:0003187)	1.85459906
75	Genetic anticipation (HP:0003743)	1.84123889
76	Abnormal drinking behavior (HP:0030082)	1.81454450
77	Polydipsia (HP:0001959)	1.81454450
78	Renal cortical cysts (HP:0000803)	1.79789993
79	Anophthalmia (HP:0000528)	1.79304922
80	Glioma (HP:0009733)	1.78080066
81	Absent radius (HP:0003974)	1.76211084
82	Furrowed tongue (HP:0000221)	1.76181882
83	Congenital hepatic fibrosis (HP:0002612)	1.75878123
84	Oligohydramnios (HP:0001562)	1.75718788
85	Postaxial foot polydactyly (HP:0001830)	1.75308965
86	Progressive cerebellar ataxia (HP:0002073)	1.74920530
87	Abnormal rod and cone electroretinograms (HP:0008323)	1.74406066
88	Abnormality of DNA repair (HP:0003254)	1.73756535
89	Aplasia involving forearm bones (HP:0009822)	1.73327400
90	Absent forearm bone (HP:0003953)	1.73327400
91	Broad-based gait (HP:0002136)	1.72014208
92	Chorioretinal atrophy (HP:0000533)	1.71297877
93	Fair hair (HP:0002286)	1.70862153
94	Genital tract atresia (HP:0001827)	1.69393887
95	Absent/shortened dynein arms (HP:0200106)	1.67981128
96	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.67981128
97	Male pseudohermaphroditism (HP:0000037)	1.67754970
98	Hyperglycinemia (HP:0002154)	1.66973067
99	Decreased central vision (HP:0007663)	1.66783804
100	Astigmatism (HP:0000483)	1.66423440

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	4.32601938
2	FRK	4.31272300
3	BMPR1B	3.14150613
4	ACVR1B	3.06220071
5	MKNK2	2.66450384
6	TLK1	2.52178602
7	WNK3	2.50942387
8	NUAK1	2.50578203
9	BRSK2	2.43296016
10	ADRBK2	2.32720222
11	TNIK	2.31390230
12	CDC7	2.07553950
13	WNK4	2.01300208
14	WEE1	1.88687734
15	CASK	1.87804323
16	PLK4	1.81632995
17	TTK	1.76522075
18	GRK1	1.75709261
19	TSSK6	1.75028043
20	MKNK1	1.69739421
21	BUB1	1.61182700
22	MAP4K2	1.57246261
23	PLK3	1.56976821
24	INSRR	1.54453615
25	VRK1	1.50915016
26	PNCK	1.44334056
27	TGFBR1	1.37277349
28	OXSR1	1.25786525
29	TRIM28	1.18827606
30	PLK1	1.18240918
31	PINK1	1.17633745
32	TAOK3	1.15270107
33	CHEK2	1.14938773
34	MAPK13	1.14749306
35	TAF1	1.11634909
36	STK38L	1.09853469
37	DAPK2	1.07962229
38	NEK2	1.06780061
39	STK3	1.05958299
40	SRPK1	1.03718223
41	MAP3K4	1.02709862
42	ATR	0.99080106
43	STK39	0.91383661
44	CAMK1D	0.90371481
45	TXK	0.90201229
46	NLK	0.88448524
47	TIE1	0.87979867
48	CAMK1G	0.84690724
49	ADRBK1	0.82835321
50	DYRK2	0.80383838
51	PBK	0.77918583
52	MELK	0.73085444
53	BRSK1	0.71007103
54	ATM	0.70634510
55	TEC	0.69449979
56	PRKCG	0.68193594
57	LATS1	0.63033433
58	RPS6KA5	0.61863914
59	FGFR2	0.61175425
60	NEK1	0.61018968
61	CSNK1G1	0.60988155
62	IRAK1	0.60601383
63	MST4	0.60203266
64	PLK2	0.58117607
65	EIF2AK3	0.56989492
66	PAK3	0.56336151
67	PKN1	0.55809675
68	PRKCE	0.54791116
69	MAPKAPK5	0.54340446
70	AURKB	0.51057888
71	EIF2AK2	0.44564686
72	FLT3	0.44559792
73	PASK	0.44135775
74	VRK2	0.43531174
75	CHEK1	0.42872371
76	DYRK3	0.41857694
77	PIK3CA	0.40299484
78	NME1	0.39504372
79	CSNK1G2	0.39371119
80	STK11	0.38447699
81	EPHA4	0.37791508
82	CDK3	0.36045028
83	CDK1	0.35825012
84	PIM1	0.35698029
85	PRKAA1	0.34828137
86	ERBB4	0.34824356
87	PRKCI	0.33203090
88	AKT3	0.31650828
89	CSNK1G3	0.31073901
90	CSNK1D	0.30884198
91	STK4	0.30866832
92	WNK1	0.30342163
93	CAMKK2	0.28942733
94	BRD4	0.28790295
95	MAP2K7	0.28122261
96	CSNK1A1L	0.27449219
97	PRKDC	0.27107544
98	SGK2	0.27054244
99	CSNK1E	0.26801428
100	PRKCQ	0.26678831

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Homologous recombination_Homo sapiens_hsa03440	3.36250269
2	Fanconi anemia pathway_Homo sapiens_hsa03460	3.06374147
3	Selenocompound metabolism_Homo sapiens_hsa00450	2.66978171
4	Basal transcription factors_Homo sapiens_hsa03022	2.60825636
5	RNA polymerase_Homo sapiens_hsa03020	2.42876311
6	Non-homologous end-joining_Homo sapiens_hsa03450	2.41947155
7	Phototransduction_Homo sapiens_hsa04744	2.36954054
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.23551568
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.15232024
10	Mismatch repair_Homo sapiens_hsa03430	2.13839669
11	Nitrogen metabolism_Homo sapiens_hsa00910	2.11123124
12	One carbon pool by folate_Homo sapiens_hsa00670	2.05318269
13	RNA degradation_Homo sapiens_hsa03018	2.00698999
14	Caffeine metabolism_Homo sapiens_hsa00232	1.90882401
15	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.89674672
16	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.85158803
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.78880028
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.75010917
19	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.70057054
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.69416607
21	DNA replication_Homo sapiens_hsa03030	1.68357758
22	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.65022477
23	Butanoate metabolism_Homo sapiens_hsa00650	1.64483668
24	Nicotine addiction_Homo sapiens_hsa05033	1.61086032
25	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.60210601
26	Protein export_Homo sapiens_hsa03060	1.49874552
27	RNA transport_Homo sapiens_hsa03013	1.48344175
28	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.48041265
29	Nucleotide excision repair_Homo sapiens_hsa03420	1.46658729
30	Propanoate metabolism_Homo sapiens_hsa00640	1.45186782
31	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.44715304
32	Tryptophan metabolism_Homo sapiens_hsa00380	1.41499223
33	Ether lipid metabolism_Homo sapiens_hsa00565	1.37681182
34	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.36291596
35	Cell cycle_Homo sapiens_hsa04110	1.35349870
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.32267131
37	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.24846223
38	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.16018417
39	Oxidative phosphorylation_Homo sapiens_hsa00190	1.15146909
40	Taste transduction_Homo sapiens_hsa04742	1.11429861
41	Olfactory transduction_Homo sapiens_hsa04740	1.10706578
42	Pyrimidine metabolism_Homo sapiens_hsa00240	1.03019143
43	Purine metabolism_Homo sapiens_hsa00230	1.02523809
44	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.00745444
45	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.99662814
46	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.94254391
47	Parkinsons disease_Homo sapiens_hsa05012	0.92510192
48	Lysine degradation_Homo sapiens_hsa00310	0.92422803
49	Huntingtons disease_Homo sapiens_hsa05016	0.88805721
50	Base excision repair_Homo sapiens_hsa03410	0.87804416
51	p53 signaling pathway_Homo sapiens_hsa04115	0.87530600
52	Spliceosome_Homo sapiens_hsa03040	0.81986865
53	ABC transporters_Homo sapiens_hsa02010	0.79008747
54	Proteasome_Homo sapiens_hsa03050	0.77386103
55	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.76512080
56	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.76429560
57	Basal cell carcinoma_Homo sapiens_hsa05217	0.75806021
58	Morphine addiction_Homo sapiens_hsa05032	0.75070471
59	Retinol metabolism_Homo sapiens_hsa00830	0.74710574
60	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.71551480
61	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.70341800
62	Serotonergic synapse_Homo sapiens_hsa04726	0.69309991
63	Glycerolipid metabolism_Homo sapiens_hsa00561	0.68834131
64	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.68545450
65	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.67487374
66	Alcoholism_Homo sapiens_hsa05034	0.66904631
67	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.66504456
68	Peroxisome_Homo sapiens_hsa04146	0.66000485
69	Steroid biosynthesis_Homo sapiens_hsa00100	0.64200740
70	Regulation of autophagy_Homo sapiens_hsa04140	0.64019658
71	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.62644527
72	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.62415388
73	Ribosome_Homo sapiens_hsa03010	0.61113604
74	Chemical carcinogenesis_Homo sapiens_hsa05204	0.60715660
75	beta-Alanine metabolism_Homo sapiens_hsa00410	0.59561480
76	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.58213774
77	Cardiac muscle contraction_Homo sapiens_hsa04260	0.57477483
78	mRNA surveillance pathway_Homo sapiens_hsa03015	0.54820507
79	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.54086917
80	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.52870778
81	Insulin secretion_Homo sapiens_hsa04911	0.52586947
82	Hippo signaling pathway_Homo sapiens_hsa04390	0.52210764
83	Glutamatergic synapse_Homo sapiens_hsa04724	0.52108198
84	Metabolic pathways_Homo sapiens_hsa01100	0.52070383
85	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.51170788
86	GABAergic synapse_Homo sapiens_hsa04727	0.47817755
87	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.47608665
88	Sulfur relay system_Homo sapiens_hsa04122	0.46768275
89	Circadian entrainment_Homo sapiens_hsa04713	0.45479785
90	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.45286110
91	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.43525456
92	Calcium signaling pathway_Homo sapiens_hsa04020	0.43049043
93	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.43006814
94	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.42179143
95	Alzheimers disease_Homo sapiens_hsa05010	0.39746451
96	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.39315481
97	Long-term depression_Homo sapiens_hsa04730	0.39213377
98	Primary immunodeficiency_Homo sapiens_hsa05340	0.38628953
99	Histidine metabolism_Homo sapiens_hsa00340	0.38493504
100	Oocyte meiosis_Homo sapiens_hsa04114	0.35535610

ZNF850

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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