ZNF852

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)4.16706805
2regulation of helicase activity (GO:0051095)3.87194577
3nuclear pore complex assembly (GO:0051292)3.85943222
4regulation of mitotic spindle checkpoint (GO:1903504)3.82597704
5regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.82597704
6DNA topological change (GO:0006265)3.76434366
7replication fork processing (GO:0031297)3.65698790
8exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.65584657
9positive regulation of histone H3-K4 methylation (GO:0051571)3.61869489
10DNA ligation (GO:0006266)3.61216424
11nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.55945742
12negative regulation of DNA-dependent DNA replication (GO:2000104)3.46484839
13nuclear pore organization (GO:0006999)3.43848212
14chromatin remodeling at centromere (GO:0031055)3.43416791
15CENP-A containing nucleosome assembly (GO:0034080)3.42745217
16DNA double-strand break processing (GO:0000729)3.39791752
17histone mRNA catabolic process (GO:0071044)3.32661540
18non-recombinational repair (GO:0000726)3.30727207
19double-strand break repair via nonhomologous end joining (GO:0006303)3.30727207
20mitotic metaphase plate congression (GO:0007080)3.29654407
21somatic diversification of immune receptors via somatic mutation (GO:0002566)3.28275272
22somatic hypermutation of immunoglobulin genes (GO:0016446)3.28275272
23maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.27084798
24DNA deamination (GO:0045006)3.19148034
25resolution of meiotic recombination intermediates (GO:0000712)3.18382088
26metaphase plate congression (GO:0051310)3.14796380
27histone mRNA metabolic process (GO:0008334)3.13141567
28DNA strand elongation involved in DNA replication (GO:0006271)3.12998883
29negative regulation of DNA recombination (GO:0045910)3.10041161
30protein prenylation (GO:0018342)3.08201202
31prenylation (GO:0097354)3.08201202
32positive regulation of granulocyte differentiation (GO:0030854)3.07447226
33protein localization to kinetochore (GO:0034501)3.06468255
34negative regulation of mitotic sister chromatid separation (GO:2000816)3.04175969
35negative regulation of sister chromatid segregation (GO:0033046)3.04175969
36negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.04175969
37negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.04175969
38negative regulation of mitotic sister chromatid segregation (GO:0033048)3.04175969
39histone exchange (GO:0043486)3.01833410
40pore complex assembly (GO:0046931)3.00260859
41spindle checkpoint (GO:0031577)2.99628189
42negative regulation of chromosome segregation (GO:0051985)2.99314086
43DNA strand elongation (GO:0022616)2.97283923
44regulation of nuclear cell cycle DNA replication (GO:0033262)2.96570861
45mitotic spindle checkpoint (GO:0071174)2.96556430
46base-excision repair, AP site formation (GO:0006285)2.95984546
47DNA catabolic process, exonucleolytic (GO:0000738)2.95014855
48mitotic recombination (GO:0006312)2.90902650
49histone H3-K4 trimethylation (GO:0080182)2.89271728
50somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.89157876
51isotype switching (GO:0045190)2.89157876
52somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.89157876
53transcription elongation from RNA polymerase I promoter (GO:0006362)2.87436020
54rRNA catabolic process (GO:0016075)2.86800205
55mitotic spindle assembly checkpoint (GO:0007094)2.86757576
56regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.85957417
57regulation of mitotic metaphase/anaphase transition (GO:0030071)2.85957417
58DNA replication-independent nucleosome organization (GO:0034724)2.85734687
59DNA replication-independent nucleosome assembly (GO:0006336)2.85734687
60negative regulation of B cell apoptotic process (GO:0002903)2.85734164
61regulation of centriole replication (GO:0046599)2.85582563
62regulation of sister chromatid segregation (GO:0033045)2.84935774
63regulation of mitotic sister chromatid separation (GO:0010965)2.84935774
64regulation of mitotic sister chromatid segregation (GO:0033047)2.84935774
65kinetochore organization (GO:0051383)2.84798282
66maturation of 5.8S rRNA (GO:0000460)2.84518488
67mitotic G2/M transition checkpoint (GO:0044818)2.84477088
68histone H2A acetylation (GO:0043968)2.84135772
69DNA replication-dependent nucleosome assembly (GO:0006335)2.82271857
70DNA replication-dependent nucleosome organization (GO:0034723)2.82271857
71spindle assembly checkpoint (GO:0071173)2.81712042
72ribosome assembly (GO:0042255)2.81301647
73mismatch repair (GO:0006298)2.80877137
74telomere maintenance via telomerase (GO:0007004)2.80452528
75DNA integration (GO:0015074)2.80158241
76protein localization to chromosome, centromeric region (GO:0071459)2.78912017
77telomere maintenance via semi-conservative replication (GO:0032201)2.78804489
78mitotic sister chromatid cohesion (GO:0007064)2.78373585
79telomere maintenance via recombination (GO:0000722)2.77244815
80dosage compensation (GO:0007549)2.77213483
81positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.76395262
82regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.76395262
83double-strand break repair via homologous recombination (GO:0000724)2.75987161
84nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)2.75670187
85termination of RNA polymerase I transcription (GO:0006363)2.75389851
86response to X-ray (GO:0010165)2.74618005
87DNA replication checkpoint (GO:0000076)2.74582127
88mitotic nuclear envelope disassembly (GO:0007077)2.74137953
89regulation of histone H3-K9 methylation (GO:0051570)2.73648387
90positive regulation of mRNA metabolic process (GO:1903313)2.73054454
91establishment of integrated proviral latency (GO:0075713)2.72410995
92centriole replication (GO:0007099)2.72383037
93purine deoxyribonucleotide catabolic process (GO:0009155)2.71947641
94recombinational repair (GO:0000725)2.71726315
95somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.70331771
96somatic cell DNA recombination (GO:0016444)2.70331771
97kinetochore assembly (GO:0051382)2.69588217
98positive regulation of histone methylation (GO:0031062)2.69248641
99somatic diversification of immune receptors (GO:0002200)2.69085693
100mitotic G2 DNA damage checkpoint (GO:0007095)2.68951768

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.38837546
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.61799072
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.48296514
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.08007949
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.87213073
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.82695479
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.61450622
8ELK1_19687146_ChIP-ChIP_HELA_Human2.57249792
9VDR_23849224_ChIP-Seq_CD4+_Human2.54092702
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.42400847
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.29786325
12ZNF274_21170338_ChIP-Seq_K562_Hela2.27129277
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.23834197
14PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22847925
15FOXP3_21729870_ChIP-Seq_TREG_Human2.10780462
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.10730404
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.09000946
18KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.07587449
19PADI4_21655091_ChIP-ChIP_MCF-7_Human2.07554499
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.07069269
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.06306062
22EWS_26573619_Chip-Seq_HEK293_Human2.04616218
23POU3F2_20337985_ChIP-ChIP_501MEL_Human2.02308799
24YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.96734944
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.96137876
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.94331518
27HOXB4_20404135_ChIP-ChIP_EML_Mouse1.85587090
28FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.85313328
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.85122302
30FUS_26573619_Chip-Seq_HEK293_Human1.83142707
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82801160
32FOXM1_23109430_ChIP-Seq_U2OS_Human1.76349171
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.76199558
34IGF1R_20145208_ChIP-Seq_DFB_Human1.71318290
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.69875647
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.66881744
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66440261
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.63910371
39VDR_22108803_ChIP-Seq_LS180_Human1.60431555
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.59349261
41CIITA_25753668_ChIP-Seq_RAJI_Human1.58747630
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.57647533
43TAF15_26573619_Chip-Seq_HEK293_Human1.51254275
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.50877659
45MYC_19030024_ChIP-ChIP_MESCs_Mouse1.46990425
46IRF8_22096565_ChIP-ChIP_GC-B_Human1.46862860
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.45800413
48IRF1_19129219_ChIP-ChIP_H3396_Human1.43048454
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.42708623
50IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.41340113
51DCP1A_22483619_ChIP-Seq_HELA_Human1.39249235
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34459417
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30855089
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.29732666
55MYC_18940864_ChIP-ChIP_HL60_Human1.27171159
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24654996
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22775821
58TTF2_22483619_ChIP-Seq_HELA_Human1.21168552
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20478555
60SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17424886
61MYC_18358816_ChIP-ChIP_MESCs_Mouse1.16382581
62GABP_19822575_ChIP-Seq_HepG2_Human1.15760499
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.14178104
64GBX2_23144817_ChIP-Seq_PC3_Human1.13800915
65NELFA_20434984_ChIP-Seq_ESCs_Mouse1.13598566
66THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11108845
67KDM5A_27292631_Chip-Seq_BREAST_Human1.09738409
68MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09330038
69P300_19829295_ChIP-Seq_ESCs_Human1.08930439
70HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.08792358
71YY1_21170310_ChIP-Seq_MESCs_Mouse1.07447422
72RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.06416707
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06045372
74ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04384572
75POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04209774
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.02591155
77ER_23166858_ChIP-Seq_MCF-7_Human1.01819073
78MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00480235
79SALL4_22934838_ChIP-ChIP_CD34+_Human0.97803836
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97320058
81MYB_26560356_Chip-Seq_TH2_Human0.95984379
82NFE2_27457419_Chip-Seq_LIVER_Mouse0.93886653
83SPI1_23547873_ChIP-Seq_NB4_Human0.93020782
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92907841
85SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91471738
86MYC_19079543_ChIP-ChIP_MESCs_Mouse0.90853001
87PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90409324
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.89091769
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89020472
90CBP_20019798_ChIP-Seq_JUKART_Human0.89020472
91EGR1_19374776_ChIP-ChIP_THP-1_Human0.88669892
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88426455
93RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88337451
94E2F1_18555785_ChIP-Seq_MESCs_Mouse0.88039440
95E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.86857390
96SUZ12_27294783_Chip-Seq_NPCs_Mouse0.86349621
97TP53_22573176_ChIP-Seq_HFKS_Human0.86133120
98SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.85084082
99MYB_26560356_Chip-Seq_TH1_Human0.85076708
100ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84845503

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.08494786
2MP0008058_abnormal_DNA_repair4.20306452
3MP0010094_abnormal_chromosome_stability3.95365592
4MP0009697_abnormal_copulation3.12223171
5MP0003111_abnormal_nucleus_morphology2.96716179
6MP0008877_abnormal_DNA_methylation2.78710299
7MP0003693_abnormal_embryo_hatching2.71641187
8MP0002396_abnormal_hematopoietic_system2.70709531
9MP0006292_abnormal_olfactory_placode2.62326680
10MP0003077_abnormal_cell_cycle2.33290809
11MP0003806_abnormal_nucleotide_metabolis2.26897649
12MP0003786_premature_aging2.26632564
13MP0004957_abnormal_blastocyst_morpholog2.23541766
14MP0008995_early_reproductive_senescence2.20984120
15MP0003718_maternal_effect2.09153311
16MP0003890_abnormal_embryonic-extraembry2.08625058
17MP0008007_abnormal_cellular_replicative2.04879094
18MP0002234_abnormal_pharynx_morphology1.97831826
19MP0002009_preneoplasia1.88906948
20MP0005645_abnormal_hypothalamus_physiol1.86932013
21MP0003195_calcinosis1.77387766
22MP0005367_renal/urinary_system_phenotyp1.67684875
23MP0000516_abnormal_urinary_system1.67684875
24MP0004808_abnormal_hematopoietic_stem1.64969983
25MP0006054_spinal_hemorrhage1.63189122
26MP0006072_abnormal_retinal_apoptosis1.63094831
27MP0001986_abnormal_taste_sensitivity1.62532762
28MP0008932_abnormal_embryonic_tissue1.61705988
29MP0006035_abnormal_mitochondrial_morpho1.55699857
30MP0000569_abnormal_digit_pigmentation1.55697510
31MP0001835_abnormal_antigen_presentation1.52537750
32MP0005220_abnormal_exocrine_pancreas1.48139740
33MP0002102_abnormal_ear_morphology1.43886993
34MP0002166_altered_tumor_susceptibility1.36896126
35MP0005084_abnormal_gallbladder_morpholo1.32875595
36MP0004043_abnormal_pH_regulation1.28344261
37MP0003787_abnormal_imprinting1.27489687
38MP0003656_abnormal_erythrocyte_physiolo1.23692890
39MP0000689_abnormal_spleen_morphology1.21334018
40MP0003763_abnormal_thymus_physiology1.20792762
41MP0010307_abnormal_tumor_latency1.19332988
42MP0003984_embryonic_growth_retardation1.18972226
43MP0005266_abnormal_metabolism1.17479369
44MP0001672_abnormal_embryogenesis/_devel1.17139011
45MP0005380_embryogenesis_phenotype1.17139011
46MP0002019_abnormal_tumor_incidence1.16879883
47MP0002006_tumorigenesis1.16852709
48MP0000350_abnormal_cell_proliferation1.14465097
49MP0002088_abnormal_embryonic_growth/wei1.14274835
50MP0003868_abnormal_feces_composition1.13814594
51MP0001697_abnormal_embryo_size1.13078676
52MP0000372_irregular_coat_pigmentation1.10571551
53MP0002398_abnormal_bone_marrow1.09146736
54MP0006036_abnormal_mitochondrial_physio1.06374497
55MP0005075_abnormal_melanosome_morpholog1.05298256
56MP0001730_embryonic_growth_arrest1.05057221
57MP0001293_anophthalmia1.01702337
58MP0003121_genomic_imprinting1.00901304
59MP0001666_abnormal_nutrient_absorption0.99428216
60MP0001929_abnormal_gametogenesis0.98352604
61MP0005397_hematopoietic_system_phenotyp0.98352044
62MP0001545_abnormal_hematopoietic_system0.98352044
63MP0000313_abnormal_cell_death0.98019744
64MP0002722_abnormal_immune_system0.96797021
65MP0004147_increased_porphyrin_level0.95937164
66MP0005253_abnormal_eye_physiology0.93756202
67MP0003221_abnormal_cardiomyocyte_apopto0.91464806
68MP0000465_gastrointestinal_hemorrhage0.89495338
69MP0000358_abnormal_cell_content/0.89348817
70MP0005395_other_phenotype0.88692682
71MP0000703_abnormal_thymus_morphology0.87231845
72MP0008961_abnormal_basal_metabolism0.86671113
73MP0002080_prenatal_lethality0.86011143
74MP0000631_abnormal_neuroendocrine_gland0.85945481
75MP0003567_abnormal_fetal_cardiomyocyte0.83814593
76MP0001764_abnormal_homeostasis0.83523962
77MP0003186_abnormal_redox_activity0.83427294
78MP0001853_heart_inflammation0.83375390
79MP0002638_abnormal_pupillary_reflex0.78513538
80MP0001119_abnormal_female_reproductive0.77506348
81MP0002822_catalepsy0.77274797
82MP0004197_abnormal_fetal_growth/weight/0.75882335
83MP0002084_abnormal_developmental_patter0.75766264
84MP0002837_dystrophic_cardiac_calcinosis0.75735425
85MP0002751_abnormal_autonomic_nervous0.75346423
86MP0002138_abnormal_hepatobiliary_system0.75280001
87MP0002086_abnormal_extraembryonic_tissu0.74945313
88MP0000653_abnormal_sex_gland0.73806085
89MP0003943_abnormal_hepatobiliary_system0.73204307
90MP0005187_abnormal_penis_morphology0.71915921
91MP0001188_hyperpigmentation0.71834160
92MP0010352_gastrointestinal_tract_polyps0.71385615
93MP0000716_abnormal_immune_system0.70702829
94MP0002429_abnormal_blood_cell0.69375189
95MP0005646_abnormal_pituitary_gland0.67537277
96MP0000613_abnormal_salivary_gland0.66989425
97MP0001661_extended_life_span0.66789100
98MP0005376_homeostasis/metabolism_phenot0.65780833
99MP0001145_abnormal_male_reproductive0.65322650
100MP0005384_cellular_phenotype0.64451235

Predicted human phenotypes

RankGene SetZ-score
1Colon cancer (HP:0003003)3.21228464
2Volvulus (HP:0002580)3.17767091
3Abnormality of B cell number (HP:0010975)2.94915684
4Abnormality of chromosome stability (HP:0003220)2.92040745
5Myelodysplasia (HP:0002863)2.88211532
6Methylmalonic acidemia (HP:0002912)2.68963329
7Renal cortical cysts (HP:0000803)2.67849243
8Abnormality of the labia minora (HP:0012880)2.62904462
9Acute lymphatic leukemia (HP:0006721)2.59232299
10Stomach cancer (HP:0012126)2.57956942
11Panhypogammaglobulinemia (HP:0003139)2.51471212
12Birth length less than 3rd percentile (HP:0003561)2.49407250
13Type I transferrin isoform profile (HP:0003642)2.46324255
14Abnormal hair whorl (HP:0010721)2.45047006
15Aplasia/Hypoplasia of the uvula (HP:0010293)2.44670699
16Neoplasm of the adrenal cortex (HP:0100641)2.44377427
17Tubulointerstitial nephritis (HP:0001970)2.43920995
18B lymphocytopenia (HP:0010976)2.42700715
19Abnormal glycosylation (HP:0012345)2.42675647
20Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.42675647
21Abnormal protein N-linked glycosylation (HP:0012347)2.42675647
22Abnormal protein glycosylation (HP:0012346)2.42675647
23Aplastic anemia (HP:0001915)2.42418069
24Pancreatic cysts (HP:0001737)2.41168859
25IgM deficiency (HP:0002850)2.40278805
26Acute myeloid leukemia (HP:0004808)2.31500589
27Abnormality of the renal cortex (HP:0011035)2.31465116
28Hypothermia (HP:0002045)2.29436733
29Medulloblastoma (HP:0002885)2.28702072
30Hyperglycinemia (HP:0002154)2.28367247
31Meckel diverticulum (HP:0002245)2.26549321
32Microvesicular hepatic steatosis (HP:0001414)2.25758786
33Severe combined immunodeficiency (HP:0004430)2.24852306
34Abnormality of the ileum (HP:0001549)2.20439920
35Cellular immunodeficiency (HP:0005374)2.20430583
36Hypomagnesemia (HP:0002917)2.17680493
37Long clavicles (HP:0000890)2.15261468
38Reduced antithrombin III activity (HP:0001976)2.15080046
39Thyroiditis (HP:0100646)2.14819762
40Gonadotropin excess (HP:0000837)2.12185831
41Intestinal atresia (HP:0011100)2.09798022
42Abnormality of the preputium (HP:0100587)2.09467301
43Chromosomal breakage induced by crosslinking agents (HP:0003221)2.07800330
44Methylmalonic aciduria (HP:0012120)2.07776256
45Sloping forehead (HP:0000340)2.05819629
46Combined immunodeficiency (HP:0005387)2.05748824
47Chromsome breakage (HP:0040012)2.03495063
48Papillary thyroid carcinoma (HP:0002895)2.02935121
49Chronic hepatic failure (HP:0100626)2.02814384
50Abnormality of the prostate (HP:0008775)2.01707784
51Hepatocellular necrosis (HP:0001404)1.99338392
52Lipid accumulation in hepatocytes (HP:0006561)1.98704885
53Neoplasm of the oral cavity (HP:0100649)1.96884452
54Clubbing of toes (HP:0100760)1.95446560
55Rhabdomyosarcoma (HP:0002859)1.94730689
56Increased hepatocellular lipid droplets (HP:0006565)1.92981530
57Autoimmune hemolytic anemia (HP:0001890)1.92599616
58Embryonal renal neoplasm (HP:0011794)1.92170044
59Pancreatic fibrosis (HP:0100732)1.90727107
60Aqueductal stenosis (HP:0002410)1.90571277
61Thyroid carcinoma (HP:0002890)1.88012967
62Glioma (HP:0009733)1.87725314
63Medial flaring of the eyebrow (HP:0010747)1.87152416
64Prominent nose (HP:0000448)1.86370535
65Mitochondrial inheritance (HP:0001427)1.85972033
66Nephroblastoma (Wilms tumor) (HP:0002667)1.85327930
67Abnormality of aspartate family amino acid metabolism (HP:0010899)1.84667084
68Neoplasm of the adrenal gland (HP:0100631)1.83809563
69Abnormality of serum amino acid levels (HP:0003112)1.83102573
70Pancreatic islet-cell hyperplasia (HP:0004510)1.80260355
71Hepatic necrosis (HP:0002605)1.80061448
72Growth hormone deficiency (HP:0000824)1.79737536
73Abnormality of methionine metabolism (HP:0010901)1.79482301
74Neoplasm of the colon (HP:0100273)1.78504295
75Abnormal delayed hypersensitivity skin test (HP:0002963)1.77830637
76Spontaneous abortion (HP:0005268)1.77589343
77Fair hair (HP:0002286)1.77545173
78Increased CSF lactate (HP:0002490)1.77497894
79Abnormality of homocysteine metabolism (HP:0010919)1.77312495
80Homocystinuria (HP:0002156)1.77312495
81Hypochromic microcytic anemia (HP:0004840)1.77177453
82Duodenal stenosis (HP:0100867)1.76364503
83Small intestinal stenosis (HP:0012848)1.76364503
84Abnormality of T cell number (HP:0011839)1.76164059
85Recurrent viral infections (HP:0004429)1.72881171
86Ependymoma (HP:0002888)1.71699117
87T lymphocytopenia (HP:0005403)1.71383152
88Multiple enchondromatosis (HP:0005701)1.71177259
89Abnormality of the vitamin B12 metabolism (HP:0004341)1.70913429
90Supernumerary spleens (HP:0009799)1.69992346
91Abnormality of the duodenum (HP:0002246)1.69370940
92Thrombocytosis (HP:0001894)1.69239935
93Abnormality of vitamin B metabolism (HP:0004340)1.67794195
94Acute encephalopathy (HP:0006846)1.66563444
95Neutropenia (HP:0001875)1.66524849
96Congenital stationary night blindness (HP:0007642)1.66089376
97Abnormality of lateral ventricle (HP:0030047)1.65367231
983-Methylglutaconic aciduria (HP:0003535)1.65117552
99Eosinophilia (HP:0001880)1.64832660
100Hyperalaninemia (HP:0003348)1.64454227

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.22693397
2ZAK3.00314892
3NUAK12.97791746
4SRPK12.82755047
5EIF2AK32.78365229
6PLK42.37195445
7AKT32.35302040
8MKNK22.24608505
9MST42.23801859
10CDC72.17102617
11MKNK12.13736011
12BRD42.12002282
13MAP3K42.02745987
14TAOK31.97371956
15TTK1.93825264
16TESK21.88802394
17BUB11.88552275
18SCYL21.85279096
19BMPR1B1.82701434
20WNK31.76324335
21ACVR1B1.74483877
22WEE11.73359558
23MAP2K71.73061227
24PBK1.71333963
25TEC1.67273866
26MAP4K21.54028078
27FLT31.49692998
28KIT1.44017362
29CCNB11.43317026
30ATR1.42009323
31PLK31.41374634
32BRSK21.40227125
33TNIK1.36415016
34VRK11.31058428
35ERBB31.17359794
36PASK1.16008368
37TRIM281.11792976
38MAPK131.02874216
39EIF2AK11.02832443
40ATM1.00222770
41PLK10.99605416
42MAP4K10.93035232
43GRK10.90993387
44EIF2AK20.90031268
45CHEK20.88241330
46VRK20.87856583
47STK40.87430715
48KDR0.84193274
49DYRK30.81098225
50YES10.80342134
51CSNK1G10.79231248
52PIK3CG0.78580345
53TSSK60.76776285
54CHEK10.74744476
55NLK0.74484842
56STK160.72725247
57SYK0.68774939
58CDK120.68690495
59AURKB0.68275475
60CSNK1A1L0.64905863
61ITK0.61708721
62RPS6KB20.60365610
63BTK0.59051107
64CASK0.55512131
65CDK30.55470880
66PLK20.54314237
67BMPR20.53304577
68MAP3K140.53206584
69CDK80.52966638
70NEK20.51685348
71CSNK1G30.51137756
72RPS6KA40.49233623
73TLK10.48964359
74LYN0.48104459
75CDK20.48007227
76CDK10.46119292
77IRAK10.45541693
78FER0.44262921
79CDK40.43167816
80CDK70.42182180
81BLK0.40424522
82SGK20.39748631
83NME10.39738922
84MAP3K50.39630555
85RPS6KA50.39570414
86EGFR0.39541371
87CSNK2A20.39360520
88TRPM70.38954831
89IKBKE0.37632306
90DYRK20.36967763
91TIE10.36923089
92PIM10.36654925
93BCR0.36142184
94MAP2K40.35842945
95TNK20.35725755
96CSNK2A10.35604012
97DYRK1A0.34771210
98FES0.34517467
99PAK30.34490836
100CAMK40.33837957

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.78585159
2Mismatch repair_Homo sapiens_hsa034303.53541555
3Homologous recombination_Homo sapiens_hsa034403.49799681
4DNA replication_Homo sapiens_hsa030303.22637736
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.13378781
6Base excision repair_Homo sapiens_hsa034103.02523167
7Fanconi anemia pathway_Homo sapiens_hsa034602.99298303
8RNA polymerase_Homo sapiens_hsa030202.73938081
9Proteasome_Homo sapiens_hsa030502.70540776
10RNA degradation_Homo sapiens_hsa030182.63530563
11Spliceosome_Homo sapiens_hsa030402.60528472
12RNA transport_Homo sapiens_hsa030132.26168601
13Basal transcription factors_Homo sapiens_hsa030222.24027993
14Nucleotide excision repair_Homo sapiens_hsa034202.20244800
15Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.94991978
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.93708685
17One carbon pool by folate_Homo sapiens_hsa006701.92660032
18Protein export_Homo sapiens_hsa030601.84417002
19Cell cycle_Homo sapiens_hsa041101.83006778
20Asthma_Homo sapiens_hsa053101.61491078
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.49805930
22Pyrimidine metabolism_Homo sapiens_hsa002401.47450037
23Propanoate metabolism_Homo sapiens_hsa006401.45255030
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39526808
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.39409543
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30585127
27mRNA surveillance pathway_Homo sapiens_hsa030151.29986392
28Systemic lupus erythematosus_Homo sapiens_hsa053221.26996050
29Purine metabolism_Homo sapiens_hsa002301.26343579
30Parkinsons disease_Homo sapiens_hsa050121.20815694
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.19570142
32Oxidative phosphorylation_Homo sapiens_hsa001901.19234297
33Primary immunodeficiency_Homo sapiens_hsa053401.18081358
34Lysine degradation_Homo sapiens_hsa003101.14894721
35Ribosome_Homo sapiens_hsa030101.06140729
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.04245818
37Peroxisome_Homo sapiens_hsa041461.03401070
38Selenocompound metabolism_Homo sapiens_hsa004501.02781930
39Allograft rejection_Homo sapiens_hsa053300.99719942
40Graft-versus-host disease_Homo sapiens_hsa053320.98534314
41Intestinal immune network for IgA production_Homo sapiens_hsa046720.97808488
42Autoimmune thyroid disease_Homo sapiens_hsa053200.97423827
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97342389
44Herpes simplex infection_Homo sapiens_hsa051680.96606547
45Type I diabetes mellitus_Homo sapiens_hsa049400.93061617
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90857235
47p53 signaling pathway_Homo sapiens_hsa041150.88280758
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87872946
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87842271
50Oocyte meiosis_Homo sapiens_hsa041140.87183086
51Huntingtons disease_Homo sapiens_hsa050160.83249256
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.82673125
53Butanoate metabolism_Homo sapiens_hsa006500.82422819
54Epstein-Barr virus infection_Homo sapiens_hsa051690.75813796
55Antigen processing and presentation_Homo sapiens_hsa046120.70652394
56Phototransduction_Homo sapiens_hsa047440.62424259
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62268876
58Fatty acid elongation_Homo sapiens_hsa000620.61743039
59Tryptophan metabolism_Homo sapiens_hsa003800.60987494
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60796847
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60109058
62Regulation of autophagy_Homo sapiens_hsa041400.59935014
63Hematopoietic cell lineage_Homo sapiens_hsa046400.59264088
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.58746175
65Pyruvate metabolism_Homo sapiens_hsa006200.57832761
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55958185
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55676930
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.53932500
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.51520499
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51436500
71Steroid biosynthesis_Homo sapiens_hsa001000.51042028
72Vitamin digestion and absorption_Homo sapiens_hsa049770.50743430
73Fatty acid metabolism_Homo sapiens_hsa012120.47741693
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45760967
75Metabolic pathways_Homo sapiens_hsa011000.45006504
76Alzheimers disease_Homo sapiens_hsa050100.37926658
77Legionellosis_Homo sapiens_hsa051340.37290179
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.36821406
79Circadian rhythm_Homo sapiens_hsa047100.36653458
80Alcoholism_Homo sapiens_hsa050340.35294394
81Taste transduction_Homo sapiens_hsa047420.35182686
82Retinol metabolism_Homo sapiens_hsa008300.35090168
83Leishmaniasis_Homo sapiens_hsa051400.33255276
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32472241
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31554574
86Viral carcinogenesis_Homo sapiens_hsa052030.30885543
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.29973375
88Staphylococcus aureus infection_Homo sapiens_hsa051500.29829493
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.28943653
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28513402
91Measles_Homo sapiens_hsa051620.27547071
92Fatty acid degradation_Homo sapiens_hsa000710.26262359
93Colorectal cancer_Homo sapiens_hsa052100.25958081
94Inositol phosphate metabolism_Homo sapiens_hsa005620.25436000
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25174324
96HTLV-I infection_Homo sapiens_hsa051660.25137269
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24959522
98Sulfur metabolism_Homo sapiens_hsa009200.22641885
99TGF-beta signaling pathway_Homo sapiens_hsa043500.22371782
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.21099509

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