ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	artery smooth muscle contraction (GO:0014824)	9.09166789
2	endosome to pigment granule transport (GO:0043485)	8.87931028
3	endosome to melanosome transport (GO:0035646)	8.87931028
4	cellular response to leptin stimulus (GO:0044320)	8.69598187
5	regulation of cilium movement (GO:0003352)	8.36834623
6	tonic smooth muscle contraction (GO:0014820)	7.90651828
7	acrosome reaction (GO:0007340)	7.58237622
8	negative regulation of multicellular organism growth (GO:0040015)	7.34521670
9	response to leptin (GO:0044321)	7.14709359
10	negative regulation of appetite (GO:0032099)	6.66829963
11	negative regulation of response to food (GO:0032096)	6.66829963
12	vasodilation (GO:0042311)	6.14272325
13	nonmotile primary cilium assembly (GO:0035058)	6.01344649
14	axoneme assembly (GO:0035082)	5.91522351
15	Golgi to endosome transport (GO:0006895)	5.83328215
16	striatum development (GO:0021756)	5.77481270
17	peptidyl-threonine dephosphorylation (GO:0035970)	5.70512535
18	brain morphogenesis (GO:0048854)	5.39636134
19	positive regulation of leukocyte degranulation (GO:0043302)	5.36996107
20	vascular smooth muscle contraction (GO:0014829)	5.25972056
21	regulation of microtubule-based movement (GO:0060632)	5.09620073
22	potassium ion import (GO:0010107)	5.02086092
23	negative regulation of cAMP-mediated signaling (GO:0043951)	4.94338222
24	G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)	4.64451857
25	regulation of response to food (GO:0032095)	4.45576725
26	mannose metabolic process (GO:0006013)	4.26859095
27	positive regulation of developmental pigmentation (GO:0048087)	4.26007776
28	regulation of appetite (GO:0032098)	4.15777660
29	calcium ion-dependent exocytosis (GO:0017156)	4.10244335
30	smooth muscle contraction (GO:0006939)	3.85783373
31	ectoderm development (GO:0007398)	3.83435068
32	rRNA catabolic process (GO:0016075)	3.71857679
33	sphingomyelin metabolic process (GO:0006684)	3.62813771
34	melanosome organization (GO:0032438)	3.55816791
35	embryonic body morphogenesis (GO:0010172)	3.52887641
36	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	3.52520081
37	regulation of mesoderm development (GO:2000380)	3.51056541
38	phospholipid dephosphorylation (GO:0046839)	3.50388619
39	phosphatidylinositol dephosphorylation (GO:0046856)	3.50138815
40	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.47791397
41	inositol phosphate dephosphorylation (GO:0046855)	3.47791397
42	positive regulation of natural killer cell activation (GO:0032816)	3.40871278
43	photoreceptor cell maintenance (GO:0045494)	3.38818310
44	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	3.38481945
45	phospholipid catabolic process (GO:0009395)	3.38247797
46	positive regulation of regulated secretory pathway (GO:1903307)	3.34317886
47	body morphogenesis (GO:0010171)	3.31948230
48	inositol phosphate catabolic process (GO:0071545)	3.31738055
49	pigment granule organization (GO:0048753)	3.31540018
50	CDP-diacylglycerol biosynthetic process (GO:0016024)	3.30932892
51	positive regulation of cAMP-mediated signaling (GO:0043950)	3.29287515
52	melanosome transport (GO:0032402)	3.27032666
53	high-density lipoprotein particle remodeling (GO:0034375)	3.23576475
54	embryonic foregut morphogenesis (GO:0048617)	3.23504981
55	peristalsis (GO:0030432)	3.23086839
56	anterior/posterior axis specification, embryo (GO:0008595)	3.18584707
57	glycerophospholipid catabolic process (GO:0046475)	3.17457280
58	heparin biosynthetic process (GO:0030210)	3.16589265
59	heparin metabolic process (GO:0030202)	3.16589265
60	pigment granule transport (GO:0051904)	3.10771747
61	behavioral response to ethanol (GO:0048149)	3.10630075
62	positive regulation of natural killer cell mediated immunity (GO:0002717)	3.07941342
63	negative regulation of response to nutrient levels (GO:0032108)	3.05434977
64	negative regulation of response to extracellular stimulus (GO:0032105)	3.05434977
65	establishment of melanosome localization (GO:0032401)	3.05416360
66	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	3.04942776
67	reverse cholesterol transport (GO:0043691)	3.03013480
68	Golgi to plasma membrane protein transport (GO:0043001)	2.94784764
69	melanosome localization (GO:0032400)	2.92072849
70	establishment of pigment granule localization (GO:0051905)	2.90802277
71	negative regulation of NF-kappaB import into nucleus (GO:0042347)	2.89960198
72	phasic smooth muscle contraction (GO:0014821)	2.89619792
73	endocrine pancreas development (GO:0031018)	2.86166640
74	hindbrain development (GO:0030902)	2.84654510
75	piRNA metabolic process (GO:0034587)	2.82316863
76	pigment granule localization (GO:0051875)	2.79161633
77	male meiosis (GO:0007140)	2.78948706
78	cellular response to sterol (GO:0036315)	2.77022772
79	cilium morphogenesis (GO:0060271)	2.76197725
80	regulation of blood vessel size (GO:0050880)	2.75207741
81	regulation of DNA damage checkpoint (GO:2000001)	2.74970694
82	regulation of tube size (GO:0035150)	2.74809529
83	single strand break repair (GO:0000012)	2.73689174
84	response to pH (GO:0009268)	2.73520935
85	urinary tract smooth muscle contraction (GO:0014848)	2.72857715
86	resolution of meiotic recombination intermediates (GO:0000712)	2.72392433
87	positive regulation of smooth muscle contraction (GO:0045987)	2.71648408
88	hematopoietic stem cell proliferation (GO:0071425)	2.70378215
89	vasoconstriction (GO:0042310)	2.70044429
90	UDP-N-acetylglucosamine metabolic process (GO:0006047)	2.69654140
91	NAD biosynthetic process (GO:0009435)	2.67807814
92	epithelial cell fate commitment (GO:0072148)	2.65450421
93	nucleoside diphosphate catabolic process (GO:0009134)	2.64059922
94	positive regulation of neurological system process (GO:0031646)	2.61610726
95	negative regulation of neurological system process (GO:0031645)	2.61140436
96	CDP-diacylglycerol metabolic process (GO:0046341)	2.60038869
97	protein polyglutamylation (GO:0018095)	2.58855645
98	spinal cord motor neuron differentiation (GO:0021522)	2.56825856
99	sulfation (GO:0051923)	2.56402291
100	response to pheromone (GO:0019236)	12.0142614

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	3.90345580
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.18970920
3	IRF1_19129219_ChIP-ChIP_H3396_Human	3.13462432
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.84498916
5	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.62773460
6	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.58287192
7	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.54584370
8	SMAD3_21741376_ChIP-Seq_EPCs_Human	2.43410908
9	EZH2_22144423_ChIP-Seq_EOC_Human	2.32116314
10	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.22244832
11	P300_19829295_ChIP-Seq_ESCs_Human	2.10484335
12	BCAT_22108803_ChIP-Seq_LS180_Human	2.07101756
13	ER_23166858_ChIP-Seq_MCF-7_Human	2.06221447
14	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.05988018
15	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.05520598
16	GBX2_23144817_ChIP-Seq_PC3_Human	1.99698225
17	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.99113992
18	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.91639724
19	RNF2_27304074_Chip-Seq_NSC_Mouse	1.88431709
20	FUS_26573619_Chip-Seq_HEK293_Human	1.86935058
21	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.84948505
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.78278320
23	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.77485419
24	IGF1R_20145208_ChIP-Seq_DFB_Human	1.76398994
25	STAT3_23295773_ChIP-Seq_U87_Human	1.76307846
26	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.74721687
27	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.73631628
28	AR_25329375_ChIP-Seq_VCAP_Human	1.67695233
29	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.65750796
30	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.64050917
31	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.62530000
32	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.62069411
33	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.61570060
34	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.60894997
35	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.60223759
36	KDM2B_26808549_Chip-Seq_REH_Human	1.57725422
37	TCF4_22108803_ChIP-Seq_LS180_Human	1.53695388
38	EWS_26573619_Chip-Seq_HEK293_Human	1.53035290
39	HTT_18923047_ChIP-ChIP_STHdh_Human	1.51378818
40	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.51359646
41	TCF4_23295773_ChIP-Seq_U87_Human	1.47241249
42	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.46680929
43	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.46202776
44	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.45116925
45	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.37391983
46	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.37281143
47	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.35450980
48	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.34448401
49	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.33996315
50	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.33823420
51	RUNX2_22187159_ChIP-Seq_PCA_Human	1.33447622
52	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.33406251
53	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.31329921
54	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.31329921
55	SMAD4_21799915_ChIP-Seq_A2780_Human	1.29899940
56	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.28623587
57	TP53_22573176_ChIP-Seq_HFKS_Human	1.28571983
58	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.28048576
59	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.25711072
60	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.25428061
61	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.24307380
62	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.22805283
63	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.22364109
64	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.21122559
65	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.20856024
66	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.20856024
67	DROSHA_22980978_ChIP-Seq_HELA_Human	1.19868790
68	REST_21632747_ChIP-Seq_MESCs_Mouse	1.18198151
69	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.17790502
70	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.17601398
71	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.16565288
72	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.15085338
73	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.14354109
74	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.13989146
75	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.13810978
76	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.13671370
77	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.12733379
78	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.12462580
79	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.12079616
80	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.12060219
81	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.11566786
82	NFYA_21822215_ChIP-Seq_K562_Human	1.11394485
83	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.11105278
84	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.09465438
85	CDX2_22108803_ChIP-Seq_LS180_Human	1.08252872
86	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.06661922
87	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.06013169
88	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.05649844
89	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.05062521
90	TP63_23658742_ChIP-Seq_EP156T_Human	1.04251265
91	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.02957342
92	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.01989519
93	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.00369647
94	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00006873
95	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.99274110
96	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.96632647
97	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.96358252
98	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.96183777
99	CBP_20019798_ChIP-Seq_JUKART_Human	0.95311074
100	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.95311074

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010386_abnormal_urinary_bladder	4.93240925
2	MP0005310_abnormal_salivary_gland	4.44252306
3	MP0001984_abnormal_olfaction	3.67225860
4	MP0002876_abnormal_thyroid_physiology	3.48058028
5	MP0002638_abnormal_pupillary_reflex	3.25847160
6	MP0001958_emphysema	3.20860892
7	MP0003941_abnormal_skin_development	2.86710072
8	MP0004145_abnormal_muscle_electrophysio	2.79250682
9	MP0002971_abnormal_brown_adipose	2.75713830
10	MP0008877_abnormal_DNA_methylation	2.72631186
11	MP0003172_abnormal_lysosome_physiology	2.59001504
12	MP0004019_abnormal_vitamin_homeostasis	2.56178595
13	MP0004215_abnormal_myocardial_fiber	2.46965452
14	MP0003186_abnormal_redox_activity	2.42118870
15	MP0000631_abnormal_neuroendocrine_gland	2.40455077
16	MP0001501_abnormal_sleep_pattern	2.37475370
17	MP0005075_abnormal_melanosome_morpholog	2.27696614
18	MP0000383_abnormal_hair_follicle	2.25949401
19	MP0000538_abnormal_urinary_bladder	2.25770027
20	MP0000015_abnormal_ear_pigmentation	2.18374967
21	MP0005085_abnormal_gallbladder_physiolo	2.10312505
22	MP0005666_abnormal_adipose_tissue	2.10163413
23	MP0010368_abnormal_lymphatic_system	1.92096042
24	MP0004885_abnormal_endolymph	1.82372664
25	MP0002168_other_aberrant_phenotype	1.79859446
26	MP0005551_abnormal_eye_electrophysiolog	1.75219843
27	MP0004510_myositis	1.73750277
28	MP0003786_premature_aging	1.70521062
29	MP0002693_abnormal_pancreas_physiology	1.67552078
30	MP0002102_abnormal_ear_morphology	1.67008601
31	MP0009046_muscle_twitch	1.60972497
32	MP0003137_abnormal_impulse_conducting	1.54140449
33	MP0001944_abnormal_pancreas_morphology	1.53051333
34	MP0002108_abnormal_muscle_morphology	1.50627619
35	MP0001764_abnormal_homeostasis	1.49823159
36	MP0010678_abnormal_skin_adnexa	1.44714837
37	MP0000566_synostosis	1.44361000
38	MP0002734_abnormal_mechanical_nocicepti	1.42918890
39	MP0000371_diluted_coat_color	1.42169127
40	MP0006072_abnormal_retinal_apoptosis	1.30802144
41	MP0003633_abnormal_nervous_system	1.27139884
42	MP0004043_abnormal_pH_regulation	1.26579418
43	MP0001486_abnormal_startle_reflex	1.21365680
44	MP0005395_other_phenotype	1.17256400
45	MP0005448_abnormal_energy_balance	1.14356014
46	MP0005535_abnormal_body_temperature	1.13869529
47	MP0002272_abnormal_nervous_system	1.13377085
48	MP0003195_calcinosis	1.12408068
49	MP0001968_abnormal_touch/_nociception	1.09226147
50	MP0001299_abnormal_eye_distance/	1.05938036
51	MP0009697_abnormal_copulation	1.05455840
52	MP0005253_abnormal_eye_physiology	1.05001256
53	MP0001765_abnormal_ion_homeostasis	1.03258329
54	MP0001188_hyperpigmentation	1.03216348
55	MP0008057_abnormal_DNA_replication	1.03116374
56	MP0005334_abnormal_fat_pad	1.02474315
57	MP0001970_abnormal_pain_threshold	1.02439591
58	MP0005646_abnormal_pituitary_gland	1.02322961
59	MP0002938_white_spotting	1.00918530
60	MP0001879_abnormal_lymphatic_vessel	1.00782981
61	MP0005377_hearing/vestibular/ear_phenot	0.99931333
62	MP0003878_abnormal_ear_physiology	0.99931333
63	MP0005375_adipose_tissue_phenotype	0.96634949
64	MP0002090_abnormal_vision	0.94703573
65	MP0002229_neurodegeneration	0.94695715
66	MP0004270_analgesia	0.94630899
67	MP0009745_abnormal_behavioral_response	0.94213685
68	MP0005257_abnormal_intraocular_pressure	0.90590252
69	MP0003646_muscle_fatigue	0.90531650
70	MP0001929_abnormal_gametogenesis	0.89558938
71	MP0002735_abnormal_chemical_nociception	0.88542896
72	MP0003119_abnormal_digestive_system	0.87071407
73	MP0000427_abnormal_hair_cycle	0.86668763
74	MP0005220_abnormal_exocrine_pancreas	0.86422277
75	MP0005369_muscle_phenotype	0.85799545
76	MP0002277_abnormal_respiratory_mucosa	0.85473189
77	MP0005197_abnormal_uvea_morphology	0.84678580
78	MP0001324_abnormal_eye_pigmentation	0.83625427
79	MP0008775_abnormal_heart_ventricle	0.81041572
80	MP0005171_absent_coat_pigmentation	0.79892183
81	MP0009780_abnormal_chondrocyte_physiolo	0.79307737
82	MP0005195_abnormal_posterior_eye	0.78514740
83	MP0001664_abnormal_digestion	0.78032593
84	MP0001485_abnormal_pinna_reflex	0.77931648
85	MP0000249_abnormal_blood_vessel	0.76803742
86	MP0002909_abnormal_adrenal_gland	0.73227544
87	MP0003937_abnormal_limbs/digits/tail_de	0.72113101
88	MP0002064_seizures	0.72068895
89	MP0002970_abnormal_white_adipose	0.70717971
90	MP0002078_abnormal_glucose_homeostasis	0.68815049
91	MP0003698_abnormal_male_reproductive	0.68135582
92	MP0005330_cardiomyopathy	0.67488329
93	MP0008872_abnormal_physiological_respon	0.66951470
94	MP0001186_pigmentation_phenotype	0.64527400
95	MP0002733_abnormal_thermal_nociception	0.64089993
96	MP0004085_abnormal_heartbeat	0.62467488
97	MP0002095_abnormal_skin_pigmentation	0.58785787
98	MP0001666_abnormal_nutrient_absorption	0.58545895
99	MP0002069_abnormal_eating/drinking_beha	0.58178764
100	MP0002572_abnormal_emotion/affect_behav	0.57645666

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Urethral obstruction (HP:0000796)	8.32240313
2	Vascular calcification (HP:0004934)	7.10181796
3	Volvulus (HP:0002580)	6.78228936
4	Cardiovascular calcification (HP:0011915)	6.32386514
5	Hyperphosphatemia (HP:0002905)	5.67933372
6	Abnormality of renal resorption (HP:0011038)	5.28478338
7	Ulnar claw (HP:0001178)	5.23552845
8	Abnormality of renal excretion (HP:0011036)	4.41454592
9	Abnormality of the dental root (HP:0006486)	3.88290492
10	Taurodontia (HP:0000679)	3.88290492
11	Abnormality of permanent molar morphology (HP:0011071)	3.88290492
12	Medial flaring of the eyebrow (HP:0010747)	3.81021791
13	Congenital primary aphakia (HP:0007707)	3.78949258
14	Hydroureter (HP:0000072)	3.77037841
15	Gait imbalance (HP:0002141)	3.75657597
16	Chronic hepatic failure (HP:0100626)	3.72868914
17	Abnormality of the dental pulp (HP:0006479)	3.66716803
18	Abnormality of molar (HP:0011077)	3.65768975
19	Abnormality of molar morphology (HP:0011070)	3.65768975
20	Short hallux (HP:0010109)	3.52069808
21	Nephrogenic diabetes insipidus (HP:0009806)	3.41498778
22	Severe visual impairment (HP:0001141)	3.27445585
23	Hypoplastic labia majora (HP:0000059)	3.24654234
24	Aplasia/Hypoplasia of the hallux (HP:0008362)	3.22951680
25	Progressive inability to walk (HP:0002505)	3.22031444
26	Prominent supraorbital ridges (HP:0000336)	3.20725325
27	Global brain atrophy (HP:0002283)	3.13239783
28	Albinism (HP:0001022)	3.02179921
29	Gaze-evoked nystagmus (HP:0000640)	2.96169977
30	Abnormality of the labia majora (HP:0012881)	2.94246943
31	Poor coordination (HP:0002370)	2.82868981
32	Abnormal eating behavior (HP:0100738)	2.80400162
33	Vaginal atresia (HP:0000148)	2.73203732
34	Polydipsia (HP:0001959)	2.68764509
35	Abnormal drinking behavior (HP:0030082)	2.68764509
36	Genital tract atresia (HP:0001827)	2.66490328
37	Wrist flexion contracture (HP:0001239)	2.64963587
38	Tubular atrophy (HP:0000092)	2.54613886
39	Preaxial foot polydactyly (HP:0001841)	2.54068304
40	Aplasia/Hypoplasia of the lens (HP:0008063)	2.46731607
41	Palpebral edema (HP:0100540)	2.45143216
42	Agitation (HP:0000713)	2.44645320
43	Specific learning disability (HP:0001328)	2.44109776
44	Spontaneous abortion (HP:0005268)	2.43380431
45	Arthropathy (HP:0003040)	2.36230475
46	Nephronophthisis (HP:0000090)	2.35981920
47	Hypoplasia of dental enamel (HP:0006297)	2.27891861
48	Constricted visual fields (HP:0001133)	2.24576005
49	Abnormality of the renal cortex (HP:0011035)	2.22220822
50	Abnormal urine output (HP:0012590)	2.22102465
51	Peripheral hypomyelination (HP:0007182)	2.21508150
52	Hypoglycemic seizures (HP:0002173)	2.20244849
53	Xerostomia (HP:0000217)	2.18537368
54	Pendular nystagmus (HP:0012043)	2.15414858
55	Overlapping toe (HP:0001845)	2.15047690
56	Reduced antithrombin III activity (HP:0001976)	2.14040479
57	Hypoplasia of the fovea (HP:0007750)	2.08900698
58	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.08900698
59	Labial hypoplasia (HP:0000066)	2.07804042
60	Generalized hypopigmentation (HP:0007513)	2.07453256
61	Inability to walk (HP:0002540)	2.03233248
62	Low anterior hairline (HP:0000294)	1.99298793
63	Abnormality of endocrine pancreas physiology (HP:0012093)	1.98215262
64	Abnormality of the pancreatic islet cells (HP:0006476)	1.98215262
65	Large for gestational age (HP:0001520)	1.97598889
66	Molar tooth sign on MRI (HP:0002419)	1.96618574
67	Abnormality of midbrain morphology (HP:0002418)	1.96618574
68	Abnormality of the renal medulla (HP:0100957)	1.95377014
69	Polyuria (HP:0000103)	1.94133022
70	Prominent nasal bridge (HP:0000426)	1.92570458
71	Abnormality of the vocal cords (HP:0008777)	1.90392105
72	Accelerated skeletal maturation (HP:0005616)	1.88854528
73	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.85493145
74	Unsteady gait (HP:0002317)	1.84019764
75	Congenital stationary night blindness (HP:0007642)	1.80976555
76	Hypoplastic female external genitalia (HP:0012815)	1.80445679
77	Attenuation of retinal blood vessels (HP:0007843)	1.80137140
78	Nephrocalcinosis (HP:0000121)	1.76880554
79	Broad foot (HP:0001769)	1.76341630
80	Pancreatic cysts (HP:0001737)	1.75229843
81	Irregular vertebral endplates (HP:0003301)	1.74901433
82	Hypothermia (HP:0002045)	1.73368166
83	Hyperinsulinemic hypoglycemia (HP:0000825)	1.69433422
84	Left ventricular hypertrophy (HP:0001712)	1.67215339
85	Optic nerve hypoplasia (HP:0000609)	1.66665279
86	Progressive cerebellar ataxia (HP:0002073)	1.66516382
87	Retinitis pigmentosa (HP:0000510)	1.65036673
88	Type I transferrin isoform profile (HP:0003642)	1.63746106
89	Tubulointerstitial abnormality (HP:0001969)	1.61864694
90	Potter facies (HP:0002009)	1.60711966
91	Facial shape deformation (HP:0011334)	1.60711966
92	Ketoacidosis (HP:0001993)	1.59967396
93	Multicystic kidney dysplasia (HP:0000003)	1.59893869
94	Abnormality of the fovea (HP:0000493)	1.58075440
95	Dyskinesia (HP:0100660)	1.57827311
96	Tubulointerstitial fibrosis (HP:0005576)	1.55138396
97	Genetic anticipation (HP:0003743)	1.54814193
98	Synophrys (HP:0000664)	1.54709144
99	Pheochromocytoma (HP:0002666)	1.54321611
100	Abnormality of macular pigmentation (HP:0008002)	1.52622457

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ACVR1B	7.16260124
2	PIK3CG	5.74920153
3	FRK	4.28765618
4	MAP3K2	3.62167641
5	EEF2K	3.39780407
6	MAPKAPK3	3.17027214
7	NTRK3	2.70155683
8	TRPM7	2.57679112
9	EIF2AK3	2.56327735
10	CASK	2.32748335
11	CAMKK2	2.30499983
12	PIK3CA	2.20761444
13	STK39	2.09734117
14	TESK1	2.02327200
15	INSRR	2.01477423
16	ADRBK2	1.86654268
17	MAPK13	1.83885824
18	WNK4	1.81270144
19	BMX	1.76910777
20	RIPK1	1.75091907
21	BMPR1B	1.73713523
22	MAP2K7	1.69004696
23	LIMK1	1.42616130
24	BRSK2	1.39430055
25	MAPKAPK5	1.31811135
26	STK24	1.23677745
27	OXSR1	1.22597789
28	TIE1	1.21841920
29	PDPK1	1.10603558
30	PDK1	1.09164538
31	KSR2	1.08141953
32	GRK1	1.07325665
33	MST4	1.00260061
34	DYRK3	0.98440592
35	SIK2	0.90652088
36	TGFBR1	0.85446839
37	VRK2	0.85165618
38	TNK2	0.77983892
39	TAOK1	0.74455866
40	PTK2B	0.71990166
41	ADRBK1	0.70474074
42	TAOK3	0.69183611
43	NUAK1	0.68372998
44	PRKAA2	0.68081086
45	STK38L	0.65546417
46	PRKCE	0.63430172
47	RPS6KB2	0.61798979
48	CAMKK1	0.59958725
49	FGFR2	0.57214828
50	TLK1	0.56375675
51	UHMK1	0.56190339
52	CDC42BPA	0.51707697
53	PAK3	0.51403081
54	IRAK2	0.50156606
55	CAMK1	0.48032129
56	MAPK15	0.47895821
57	MELK	0.47652076
58	MAP2K1	0.46126893
59	EPHB2	0.44225803
60	RPS6KA5	0.43318288
61	DYRK1A	0.42101751
62	MAP3K1	0.40705277
63	WNK3	0.39590963
64	ABL2	0.39103451
65	PRKAA1	0.39044097
66	GRK5	0.38688057
67	MAPK11	0.38328846
68	MAP3K4	0.33848089
69	RET	0.31626905
70	MET	0.31382288
71	PKN1	0.30983115
72	KSR1	0.30857546
73	NTRK2	0.29803960
74	STK11	0.29439159
75	PRKCG	0.28121290
76	WNK1	0.28081884
77	CAMK2A	0.27252156
78	TNIK	0.25918401
79	CSNK1A1	0.25911778
80	PHKG1	0.24917974
81	PHKG2	0.24917974
82	VRK1	0.24652218
83	MAP2K4	0.23808024
84	ZAK	0.22654555
85	CAMK4	0.17962222
86	CAMK2D	0.17438832
87	BRSK1	0.16747489
88	JAK3	0.16695936
89	CAMK1D	0.16276414
90	STK3	0.15243596
91	PLK4	0.14420368
92	OBSCN	0.12783313
93	MAP2K2	0.12762770
94	MAP3K7	0.12407846
95	IRAK1	0.12252955
96	PRKACA	0.11926547
97	MAPK7	0.11145275
98	DAPK2	0.10687307
99	PLK2	0.10158122
100	CAMK1G	0.10034397

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	3.95856155
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.67686547
3	Butanoate metabolism_Homo sapiens_hsa00650	3.17536834
4	Sulfur metabolism_Homo sapiens_hsa00920	2.95045765
5	Starch and sucrose metabolism_Homo sapiens_hsa00500	2.56578476
6	Insulin secretion_Homo sapiens_hsa04911	2.25281444
7	Sphingolipid metabolism_Homo sapiens_hsa00600	2.22439193
8	ABC transporters_Homo sapiens_hsa02010	2.20757809
9	Inositol phosphate metabolism_Homo sapiens_hsa00562	2.20524246
10	Selenocompound metabolism_Homo sapiens_hsa00450	2.13482712
11	Protein export_Homo sapiens_hsa03060	2.11529477
12	Circadian rhythm_Homo sapiens_hsa04710	1.99167875
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.98739231
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.92122388
15	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.90063445
16	Ether lipid metabolism_Homo sapiens_hsa00565	1.80865989
17	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.77944617
18	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.76153111
19	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.72018485
20	Oxidative phosphorylation_Homo sapiens_hsa00190	1.71425008
21	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.68389447
22	Nitrogen metabolism_Homo sapiens_hsa00910	1.66688066
23	Taste transduction_Homo sapiens_hsa04742	1.59248245
24	Phototransduction_Homo sapiens_hsa04744	1.42599250
25	Oocyte meiosis_Homo sapiens_hsa04114	1.41432410
26	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.38726613
27	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.38374599
28	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.33274974
29	Caffeine metabolism_Homo sapiens_hsa00232	1.26059506
30	Calcium signaling pathway_Homo sapiens_hsa04020	1.22919684
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.17895358
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.17539067
33	Type II diabetes mellitus_Homo sapiens_hsa04930	1.17273180
34	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.09717969
35	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	1.08907987
36	Pancreatic secretion_Homo sapiens_hsa04972	1.06809953
37	Salivary secretion_Homo sapiens_hsa04970	1.06671223
38	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.03987690
39	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.00438328
40	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.99705780
41	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.99131564
42	Renin-angiotensin system_Homo sapiens_hsa04614	0.96179073
43	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.95596233
44	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.93077622
45	Folate biosynthesis_Homo sapiens_hsa00790	0.90194084
46	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.89683408
47	Circadian entrainment_Homo sapiens_hsa04713	0.88411184
48	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.88377023
49	Long-term depression_Homo sapiens_hsa04730	0.88139498
50	Tryptophan metabolism_Homo sapiens_hsa00380	0.86894606
51	Gastric acid secretion_Homo sapiens_hsa04971	0.84062825
52	Serotonergic synapse_Homo sapiens_hsa04726	0.83617967
53	Huntingtons disease_Homo sapiens_hsa05016	0.83405134
54	Nicotine addiction_Homo sapiens_hsa05033	0.81423619
55	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.79508910
56	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.79383645
57	Fatty acid elongation_Homo sapiens_hsa00062	0.78994263
58	Alzheimers disease_Homo sapiens_hsa05010	0.78789403
59	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.75969718
60	Parkinsons disease_Homo sapiens_hsa05012	0.75934533
61	Cardiac muscle contraction_Homo sapiens_hsa04260	0.74268090
62	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.74037391
63	Propanoate metabolism_Homo sapiens_hsa00640	0.73974149
64	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.70954194
65	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.70244601
66	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.68671890
67	Cholinergic synapse_Homo sapiens_hsa04725	0.68297885
68	Chemical carcinogenesis_Homo sapiens_hsa05204	0.66230431
69	Retinol metabolism_Homo sapiens_hsa00830	0.66222867
70	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.64220971
71	Collecting duct acid secretion_Homo sapiens_hsa04966	0.62242288
72	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.61117584
73	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.59845890
74	Renin secretion_Homo sapiens_hsa04924	0.58635209
75	Metabolic pathways_Homo sapiens_hsa01100	0.58318287
76	Amphetamine addiction_Homo sapiens_hsa05031	0.57892266
77	Lysosome_Homo sapiens_hsa04142	0.55853638
78	Fanconi anemia pathway_Homo sapiens_hsa03460	0.55840233
79	Basal transcription factors_Homo sapiens_hsa03022	0.54944985
80	Homologous recombination_Homo sapiens_hsa03440	0.53496264
81	Olfactory transduction_Homo sapiens_hsa04740	0.49671716
82	Fat digestion and absorption_Homo sapiens_hsa04975	0.47644783
83	Glycerolipid metabolism_Homo sapiens_hsa00561	0.47080949
84	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.45778498
85	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.42527279
86	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.42315340
87	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.41270874
88	Morphine addiction_Homo sapiens_hsa05032	0.40032086
89	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.39082363
90	Dopaminergic synapse_Homo sapiens_hsa04728	0.38254913
91	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.34654725
92	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.34290420
93	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.33550466
94	Glutamatergic synapse_Homo sapiens_hsa04724	0.31094144
95	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.30556993
96	Mineral absorption_Homo sapiens_hsa04978	0.29838045
97	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.29027069
98	cAMP signaling pathway_Homo sapiens_hsa04024	0.28260681
99	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.24272729
100	RNA polymerase_Homo sapiens_hsa03020	0.22609917

ZNF859P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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