ZNF862

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.25667742
2negative regulation of cell killing (GO:0031342)5.00033274
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.00033274
4regulation of gamma-delta T cell differentiation (GO:0045586)4.38566005
5negative regulation of erythrocyte differentiation (GO:0045647)4.32406581
6regulation of gamma-delta T cell activation (GO:0046643)4.29549631
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.18505789
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.14842605
9positive thymic T cell selection (GO:0045059)4.08771775
10antigen processing and presentation of endogenous antigen (GO:0019883)4.07857366
11negative thymic T cell selection (GO:0045060)3.97062613
12thymic T cell selection (GO:0045061)3.80693616
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.79238838
14negative T cell selection (GO:0043383)3.77988394
15positive T cell selection (GO:0043368)3.59217986
16activated T cell proliferation (GO:0050798)3.55884205
17T cell selection (GO:0045058)3.49350823
18leukocyte aggregation (GO:0070486)3.40169568
19positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.34614948
20regulation of ARF protein signal transduction (GO:0032012)3.31574446
21regulation of B cell receptor signaling pathway (GO:0050855)3.24268725
22regulation of ARF GTPase activity (GO:0032312)3.21119921
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.21002322
24positive regulation by symbiont of host defense response (GO:0052509)3.19897349
25modulation by symbiont of host defense response (GO:0052031)3.19897349
26modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.19897349
27modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.19897349
28positive regulation by organism of defense response of other organism involved in symbiotic interact3.19897349
29modulation by symbiont of host immune response (GO:0052553)3.19897349
30response to interleukin-15 (GO:0070672)3.18471997
31detection of bacterium (GO:0016045)3.13831224
32negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.12565234
33detection of other organism (GO:0098543)3.10208546
34macrophage activation involved in immune response (GO:0002281)3.09708219
35negative regulation of lymphocyte mediated immunity (GO:0002707)3.08379190
36B cell receptor signaling pathway (GO:0050853)3.01505766
37mannose metabolic process (GO:0006013)2.99736674
38response to muramyl dipeptide (GO:0032495)2.88100177
39signal complex assembly (GO:0007172)2.87889229
40negative regulation of leukocyte mediated immunity (GO:0002704)2.86882280
41positive regulation of granulocyte differentiation (GO:0030854)2.83583203
42positive regulation of Rap GTPase activity (GO:0032854)2.81082843
43cilium or flagellum-dependent cell motility (GO:0001539)2.74482288
44histone H3-K36 demethylation (GO:0070544)2.74370650
45regulation of T cell tolerance induction (GO:0002664)2.74111004
46peptidyl-tyrosine autophosphorylation (GO:0038083)2.74013176
47germinal center formation (GO:0002467)2.72902936
48regulation of tolerance induction (GO:0002643)2.69499215
49negative regulation of T cell mediated immunity (GO:0002710)2.64266832
50regulation of T-helper 2 cell differentiation (GO:0045628)2.63505237
51positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.62893177
52cellular response to interleukin-15 (GO:0071350)2.62008342
53positive regulation of B cell differentiation (GO:0045579)2.61423317
54tolerance induction (GO:0002507)2.60750534
55detection of external biotic stimulus (GO:0098581)2.59625923
56negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.59106941
57response to type I interferon (GO:0034340)2.56798681
58regulation of B cell differentiation (GO:0045577)2.55652763
59negative regulation of type 2 immune response (GO:0002829)2.52134665
60histone H3-K4 trimethylation (GO:0080182)2.51562902
61cellular response to type I interferon (GO:0071357)2.51040309
62type I interferon signaling pathway (GO:0060337)2.51040309
63positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.48910536
64regulation of granulocyte differentiation (GO:0030852)2.48212955
65response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.48114111
66response to host immune response (GO:0052572)2.48114111
67response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.47355973
68response to host (GO:0075136)2.47355973
69response to host defenses (GO:0052200)2.47355973
70positive regulation of histone deacetylation (GO:0031065)2.44757183
71negative regulation of T-helper cell differentiation (GO:0045623)2.43121010
72negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.43121010
73response to laminar fluid shear stress (GO:0034616)2.39249309
74positive regulation of CREB transcription factor activity (GO:0032793)2.38617130
75regulation of Rap GTPase activity (GO:0032317)2.34377682
76positive regulation of tolerance induction (GO:0002645)2.31323516
77immunoglobulin mediated immune response (GO:0016064)2.30891078
78T cell homeostasis (GO:0043029)2.29566881
79histone H4 deacetylation (GO:0070933)2.27772752
80detection of biotic stimulus (GO:0009595)2.27429087
81histone lysine demethylation (GO:0070076)2.26218045
82positive regulation of protein deacetylation (GO:0090312)2.23359496
83negative regulation of glycoprotein biosynthetic process (GO:0010561)2.23339231
84antigen receptor-mediated signaling pathway (GO:0050851)2.22837091
85histone H3-K9 demethylation (GO:0033169)2.21835086
86regulation of myeloid leukocyte mediated immunity (GO:0002886)2.21560849
87detection of molecule of bacterial origin (GO:0032490)2.20593211
88activation of JUN kinase activity (GO:0007257)2.19969750
89regulation of regulatory T cell differentiation (GO:0045589)2.19697322
90negative regulation of innate immune response (GO:0045824)2.19535856
91antigen processing and presentation via MHC class Ib (GO:0002475)2.19479949
92regulation of leukocyte degranulation (GO:0043300)2.18619676
93neutrophil activation involved in immune response (GO:0002283)2.18594105
94regulation of natural killer cell mediated immunity (GO:0002715)2.17888840
95regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.17888840
96negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.17536395
97interferon-gamma-mediated signaling pathway (GO:0060333)2.16459003
98cellular extravasation (GO:0045123)2.14418940
99regulation of amyloid precursor protein catabolic process (GO:1902991)2.14246635
100regulation of beta-amyloid formation (GO:1902003)2.14182324

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.23872791
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.11721224
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.92044060
4KDM2B_26808549_Chip-Seq_SUP-B15_Human2.80996982
5VDR_21846776_ChIP-Seq_THP-1_Human2.41017042
6KDM2B_26808549_Chip-Seq_DND41_Human2.36791190
7DROSHA_22980978_ChIP-Seq_HELA_Human2.34716332
8VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.33404372
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.25943427
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.25470813
11TCF7_22412390_ChIP-Seq_EML_Mouse2.19827470
12LXR_22292898_ChIP-Seq_THP-1_Human2.19266970
13KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.13621652
14RUNX_20019798_ChIP-Seq_JUKART_Human2.07324653
15EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.06674898
16MYC_22102868_ChIP-Seq_BL_Human2.06435368
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.89910233
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.89224811
19VDR_24763502_ChIP-Seq_THP-1_Human1.88045167
20E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.87995571
21KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.85109494
22MAF_26560356_Chip-Seq_TH1_Human1.84334757
23KDM2B_26808549_Chip-Seq_K562_Human1.80218300
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.78116689
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.77932088
26ELK3_25401928_ChIP-Seq_HUVEC_Human1.76311218
27KDM2B_26808549_Chip-Seq_JURKAT_Human1.75043627
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74039195
29SCL_19346495_ChIP-Seq_HPC-7_Human1.73784359
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.67453538
31UTX_26944678_Chip-Seq_JUKART_Human1.64682628
32SPI1_23127762_ChIP-Seq_K562_Human1.63736759
33GATA1_19941827_ChIP-Seq_MEL_Mouse1.61638997
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.61616958
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.59035390
36GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.56615728
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.56318843
38MAF_26560356_Chip-Seq_TH2_Human1.54630832
39CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.54104861
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.50918350
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.50672981
42EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.48357697
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.47925581
44DNAJC2_21179169_ChIP-ChIP_NT2_Human1.43433326
45SMC4_20622854_ChIP-Seq_HELA_Human1.42117736
46IRF8_27001747_Chip-Seq_BMDM_Mouse1.38329748
47RACK7_27058665_Chip-Seq_MCF-7_Human1.36966700
48NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35378137
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.33006790
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.30659513
51TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29210139
52P68_20966046_ChIP-Seq_HELA_Human1.26172580
53SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25531068
54SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.21832106
55SA1_27219007_Chip-Seq_ERYTHROID_Human1.21719910
56ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19122018
57MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19082217
58ZFP281_27345836_Chip-Seq_ESCs_Mouse1.19043372
59RUNX1_27514584_Chip-Seq_MCF-7_Human1.16814803
60CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16682408
61BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16588478
62STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.14359382
63CREB1_26743006_Chip-Seq_LNCaP_Human1.13530584
64TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13502407
65IRF8_21731497_ChIP-ChIP_J774_Mouse1.13047091
66MYB_26560356_Chip-Seq_TH2_Human1.11042572
67VDR_24787735_ChIP-Seq_THP-1_Human1.09546486
68BCL6_27268052_Chip-Seq_Bcells_Human1.08395406
69SMAD_19615063_ChIP-ChIP_OVARY_Human1.07904104
70EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.07565318
71MYB_26560356_Chip-Seq_TH1_Human1.05795772
72ERG_21242973_ChIP-ChIP_JURKAT_Human1.03834162
73TP63_22573176_ChIP-Seq_HFKS_Human1.02101112
74RARB_27405468_Chip-Seq_BRAIN_Mouse1.01797173
75ELF1_20517297_ChIP-Seq_JURKAT_Human1.01705854
76CTCF_27219007_Chip-Seq_Bcells_Human1.01067369
77WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00541339
78BCOR_27268052_Chip-Seq_Bcells_Human1.00094157
79DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99717409
80GATA1_19941826_ChIP-Seq_K562_Human0.99189284
81PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98820452
82MYB_21317192_ChIP-Seq_ERMYB_Mouse0.95920205
83SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.95577344
84GATA3_27048872_Chip-Seq_THYMUS_Human0.94837393
85GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94375295
86EGR1_19374776_ChIP-ChIP_THP-1_Human0.94146723
87PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93712083
88CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93703531
89SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93691880
90PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91550603
91RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.91348843
92SUZ12_27294783_Chip-Seq_ESCs_Mouse0.91048264
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90117438
94TP63_17297297_ChIP-ChIP_HaCaT_Human0.88828698
95LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88431213
96CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.88030248
97SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.87923136
98OCT4_19829295_ChIP-Seq_ESCs_Human0.87333074
99GATA2_21666600_ChIP-Seq_HMVEC_Human0.87327725
100NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.86718282

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to3.30990690
2MP0003172_abnormal_lysosome_physiology2.96517099
3MP0003763_abnormal_thymus_physiology2.87138923
4MP0003724_increased_susceptibility_to2.84340265
5MP0001835_abnormal_antigen_presentation2.63531687
6MP0003303_peritoneal_inflammation2.51441337
7MP0001800_abnormal_humoral_immune2.44281311
8MP0003300_gastrointestinal_ulcer2.40767864
9MP0004381_abnormal_hair_follicle2.35615214
10MP0001790_abnormal_immune_system2.33131849
11MP0005387_immune_system_phenotype2.33131849
12MP0005000_abnormal_immune_tolerance2.12661447
13MP0008260_abnormal_autophagy2.04079543
14MP0002419_abnormal_innate_immunity2.03648804
15MP0005025_abnormal_response_to2.01692614
16MP0002723_abnormal_immune_serum1.93828481
17MP0009278_abnormal_bone_marrow1.93676883
18MP0003866_abnormal_defecation1.90125805
19MP0002420_abnormal_adaptive_immunity1.89576046
20MP0001819_abnormal_immune_cell1.86712159
21MP0003183_abnormal_peptide_metabolism1.83371016
22MP0003690_abnormal_glial_cell1.83141676
23MP0004859_abnormal_synaptic_plasticity1.79758710
24MP0002452_abnormal_antigen_presenting1.75630143
25MP0001958_emphysema1.74865946
26MP0005671_abnormal_response_to1.70002754
27MP0005058_abnormal_lysosome_morphology1.66956119
28MP0002933_joint_inflammation1.66429700
29MP0004947_skin_inflammation1.64991837
30MP0002396_abnormal_hematopoietic_system1.63666928
31MP0001873_stomach_inflammation1.63419828
32MP0002405_respiratory_system_inflammati1.62114664
33MP0010155_abnormal_intestine_physiology1.61806459
34MP0003279_aneurysm1.61724325
35MP0000685_abnormal_immune_system1.60208322
36MP0003705_abnormal_hypodermis_morpholog1.58232463
37MP0003191_abnormal_cellular_cholesterol1.56199809
38MP0001533_abnormal_skeleton_physiology1.50853760
39MP0004858_abnormal_nervous_system1.50554263
40MP0000465_gastrointestinal_hemorrhage1.48166988
41MP0000716_abnormal_immune_system1.47563592
42MP0002398_abnormal_bone_marrow1.44459631
43MP0005409_darkened_coat_color1.37253778
44MP0004130_abnormal_muscle_cell1.35650215
45MP0000703_abnormal_thymus_morphology1.35556434
46MP0006082_CNS_inflammation1.34008618
47MP0003045_fibrosis1.26516626
48MP0003329_amyloid_beta_deposits1.26465344
49MP0003091_abnormal_cell_migration1.25066044
50MP0002822_catalepsy1.24998390
51MP0005464_abnormal_platelet_physiology1.19238379
52MP0002998_abnormal_bone_remodeling1.17755642
53MP0001851_eye_inflammation1.11034161
54MP0003828_pulmonary_edema1.09160184
55MP0000689_abnormal_spleen_morphology1.08212099
56MP0002249_abnormal_larynx_morphology1.07295017
57MP0001986_abnormal_taste_sensitivity1.06357055
58MP0000604_amyloidosis1.06081517
59MP0009785_altered_susceptibility_to1.05802638
60MP0002722_abnormal_immune_system1.05252794
61MP0002009_preneoplasia1.05103009
62MP0001845_abnormal_inflammatory_respons1.05061515
63MP0001849_ear_inflammation1.03566296
64MP0004808_abnormal_hematopoietic_stem1.03129419
65MP0002429_abnormal_blood_cell1.01482934
66MP0008961_abnormal_basal_metabolism1.00599631
67MP0005075_abnormal_melanosome_morpholog0.96896562
68MP0005397_hematopoietic_system_phenotyp0.96728879
69MP0001545_abnormal_hematopoietic_system0.96728879
70MP0008569_lethality_at_weaning0.95054125
71MP0004510_myositis0.94872856
72MP0001502_abnormal_circadian_rhythm0.92755459
73MP0004883_abnormal_blood_vessel0.92064550
74MP0003075_altered_response_to0.91433417
75MP0009333_abnormal_splenocyte_physiolog0.89868550
76MP0000920_abnormal_myelination0.89085659
77MP0002132_abnormal_respiratory_system0.87995326
78MP0002653_abnormal_ependyma_morphology0.86525864
79MP0001348_abnormal_lacrimal_gland0.85620955
80MP0005451_abnormal_body_composition0.85503735
81MP0002148_abnormal_hypersensitivity_rea0.85263355
82MP0002166_altered_tumor_susceptibility0.85151017
83MP0005310_abnormal_salivary_gland0.84494058
84MP0005423_abnormal_somatic_nervous0.84168155
85MP0008874_decreased_physiological_sensi0.84004380
86MP0003635_abnormal_synaptic_transmissio0.83795765
87MP0005390_skeleton_phenotype0.81076174
88MP0005248_abnormal_Harderian_gland0.80955538
89MP0000015_abnormal_ear_pigmentation0.79971231
90MP0009384_cardiac_valve_regurgitation0.79390036
91MP0002063_abnormal_learning/memory/cond0.77971492
92MP0005166_decreased_susceptibility_to0.75135117
93MP0005503_abnormal_tendon_morphology0.74671049
94MP0005535_abnormal_body_temperature0.74477271
95MP0000858_altered_metastatic_potential0.74351424
96MP0001663_abnormal_digestive_system0.73528563
97MP0000249_abnormal_blood_vessel0.73430856
98MP0003879_abnormal_hair_cell0.72753837
99MP0008469_abnormal_protein_level0.72656313
100MP0001853_heart_inflammation0.70831756

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)4.58886144
2Eczematoid dermatitis (HP:0000976)4.14668419
3Colitis (HP:0002583)3.43518137
4Papilledema (HP:0001085)3.38352261
5Abnormality of the fingertips (HP:0001211)3.32001381
6Recurrent abscess formation (HP:0002722)3.14510798
7Broad face (HP:0000283)3.13837293
8Myositis (HP:0100614)3.09436111
9Panhypogammaglobulinemia (HP:0003139)3.04575557
10Gastrointestinal inflammation (HP:0004386)3.00086413
11Abnormal delayed hypersensitivity skin test (HP:0002963)2.98988475
12Recurrent bacterial skin infections (HP:0005406)2.96623017
13Inflammation of the large intestine (HP:0002037)2.94225767
14Recurrent fungal infections (HP:0002841)2.91272004
15Chronic mucocutaneous candidiasis (HP:0002728)2.85697208
16Recurrent cutaneous fungal infections (HP:0011370)2.85697208
17Gingivitis (HP:0000230)2.82472357
18Increased IgE level (HP:0003212)2.72669298
19Gastrointestinal infarctions (HP:0005244)2.64573534
20Nasal polyposis (HP:0100582)2.60954468
21Spontaneous hematomas (HP:0007420)2.57954856
22Orchitis (HP:0100796)2.54635690
23Cerebral aneurysm (HP:0004944)2.52933069
24Recurrent gram-negative bacterial infections (HP:0005420)2.52335943
25Elevated erythrocyte sedimentation rate (HP:0003565)2.47066206
26Meningitis (HP:0001287)2.46967404
27Abnormality of the nasal mucosa (HP:0000433)2.44087356
28Prolonged bleeding time (HP:0003010)2.40597697
29Supranuclear gaze palsy (HP:0000605)2.38600370
30Cellulitis (HP:0100658)2.37288394
31Agammaglobulinemia (HP:0004432)2.33090791
32Recurrent skin infections (HP:0001581)2.32339091
33Genetic anticipation (HP:0003743)2.32291510
34Abnormality of macrophages (HP:0004311)2.31361374
35Mediastinal lymphadenopathy (HP:0100721)2.28741374
36Retrobulbar optic neuritis (HP:0100654)2.28358060
37Optic neuritis (HP:0100653)2.28358060
38Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.18699487
39Thin bony cortex (HP:0002753)2.18687398
40Chest pain (HP:0100749)2.17123695
41Ankle clonus (HP:0011448)2.15342272
42Recurrent bronchitis (HP:0002837)2.13904747
43Absent/shortened dynein arms (HP:0200106)2.10890302
44Dynein arm defect of respiratory motile cilia (HP:0012255)2.10890302
45Urinary glycosaminoglycan excretion (HP:0003541)2.09401127
46Mucopolysacchariduria (HP:0008155)2.09401127
47Chronic obstructive pulmonary disease (HP:0006510)2.09130491
48Obstructive lung disease (HP:0006536)2.09130491
49Recurrent viral infections (HP:0004429)2.08200446
50Slow saccadic eye movements (HP:0000514)2.06407218
51Vasculitis (HP:0002633)2.06084840
52Abnormality of glycosaminoglycan metabolism (HP:0004371)2.05033404
53Abnormality of mucopolysaccharide metabolism (HP:0011020)2.05033404
54Abnormality of polysaccharide metabolism (HP:0011012)2.05033404
55Encephalitis (HP:0002383)2.01264800
56Hemoptysis (HP:0002105)2.00860922
57Spinal canal stenosis (HP:0003416)2.00621192
58Emphysema (HP:0002097)1.99440623
59Dysostosis multiplex (HP:0000943)1.97422438
60Neoplasm of the heart (HP:0100544)1.96767257
61Abnormality of binocular vision (HP:0011514)1.96498633
62Diplopia (HP:0000651)1.96498633
63Stomatitis (HP:0010280)1.95246696
64Cervical subluxation (HP:0003308)1.93075056
65Aneurysm (HP:0002617)1.90338477
66Viral hepatitis (HP:0006562)1.90244056
67Chronic otitis media (HP:0000389)1.89012468
68T lymphocytopenia (HP:0005403)1.88800987
69Sleep apnea (HP:0010535)1.88159515
70Pustule (HP:0200039)1.87594173
71Abnormal ciliary motility (HP:0012262)1.87338854
72Neurofibrillary tangles (HP:0002185)1.86156478
73Pulmonary infiltrates (HP:0002113)1.84699432
74Annular pancreas (HP:0001734)1.84500459
75Gastrointestinal stroma tumor (HP:0100723)1.81501100
76Restrictive lung disease (HP:0002091)1.77309047
77Epistaxis (HP:0000421)1.74313272
78Aortic aneurysm (HP:0004942)1.73125055
79Hemiplegia (HP:0002301)1.71889315
80Recurrent sinusitis (HP:0011108)1.70737619
81Mitral regurgitation (HP:0001653)1.69364148
82Polygenic inheritance (HP:0010982)1.67012898
83Dilatation of the ascending aorta (HP:0005111)1.65361441
84Spondylolisthesis (HP:0003302)1.64958224
85J-shaped sella turcica (HP:0002680)1.62863687
86Asymmetric septal hypertrophy (HP:0001670)1.62540596
87Gingival bleeding (HP:0000225)1.62364991
88Interstitial pulmonary disease (HP:0006530)1.61364258
89Pulmonary embolism (HP:0002204)1.61003745
90Metaphyseal cupping (HP:0003021)1.60943609
91Abnormality of the columella (HP:0009929)1.60320776
92Hemorrhage of the eye (HP:0011885)1.60255464
93Neuronal loss in central nervous system (HP:0002529)1.60093829
94Increased CSF protein (HP:0002922)1.58948853
95Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.58212031
96Recurrent otitis media (HP:0000403)1.57691523
97Verrucae (HP:0200043)1.57238536
98Papilloma (HP:0012740)1.57238536
99Abnormality of T cell number (HP:0011839)1.56667085
100Dislocated radial head (HP:0003083)1.55965287

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.07139295
2TRIB32.92884825
3RIPK42.67229305
4TNK22.62429228
5ERN12.41907345
6PRPF4B2.34817636
7MARK22.12859676
8TYK22.11091788
9EPHB11.94476806
10FES1.93453940
11BLK1.84826357
12SIK11.84396462
13ZAP701.72337444
14MAP2K31.67761167
15TXK1.61309768
16MAPK151.60005830
17MAP3K131.55802164
18SIK21.55131391
19MAP3K71.54323023
20CDC42BPA1.52003792
21GRK61.48665048
22CSK1.44970336
23CAMKK11.42139602
24CDK121.40668561
25JAK11.40664173
26FGFR41.40173200
27BTK1.40121243
28RIPK11.33077462
29PRKD21.30856280
30TYRO31.21453413
31HCK1.20686387
32MAP3K61.19223635
33IRAK41.18227228
34TAOK11.16232122
35PKN21.11891774
36SYK1.11885696
37JAK31.10464340
38IKBKE1.10152175
39HIPK21.09003908
40MAPK71.06888420
41ITK1.05326408
42MAP3K31.01390895
43MAPK121.00850056
44SIK30.97640191
45MAP3K100.95089773
46PRKD30.94593893
47TBK10.92771512
48PTK60.90431878
49FGFR30.89295982
50MAP2K60.88779999
51STK380.88037306
52LCK0.87828595
53RET0.87393691
54SMG10.87059426
55KIT0.84969768
56CSF1R0.84950713
57FGFR20.81934952
58RPS6KA20.81816439
59SGK20.81386587
60PDK10.80987629
61PTK2B0.80429724
62SGK30.80060574
63PRKCH0.79636933
64JAK20.79463345
65NTRK20.78126068
66MAP3K10.77632910
67DYRK1B0.75354832
68KSR20.73798723
69MAP3K110.73730028
70SGK4940.71431078
71SGK2230.71431078
72PDGFRB0.71249095
73NTRK30.70899558
74PDPK10.69835279
75LYN0.67999735
76EPHA30.67700133
77ICK0.67257220
78FYN0.67208912
79RPS6KL10.66973440
80RPS6KC10.66973440
81STK110.66247115
82MAP3K140.63399837
83MARK30.61965431
84UHMK10.60740226
85MAP2K40.60016236
86PDGFRA0.59809507
87WNK10.58511233
88CAMKK20.56668761
89TTN0.56291073
90RPS6KA60.54940967
91TAOK30.54692393
92MTOR0.54315104
93ERBB20.53891996
94CAMK40.53592841
95MAP2K20.51495434
96LRRK20.50474202
97PRKD10.49963960
98NLK0.49647238
99EEF2K0.47833809
100CAMK10.46426953

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046621.87666930
2Osteoclast differentiation_Homo sapiens_hsa043801.86217802
3Acute myeloid leukemia_Homo sapiens_hsa052211.72734567
4Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.66193796
5Leishmaniasis_Homo sapiens_hsa051401.62850801
6Other glycan degradation_Homo sapiens_hsa005111.59680588
7T cell receptor signaling pathway_Homo sapiens_hsa046601.59246970
8Notch signaling pathway_Homo sapiens_hsa043301.58005096
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.54353820
10Primary immunodeficiency_Homo sapiens_hsa053401.46067734
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.44229879
12Staphylococcus aureus infection_Homo sapiens_hsa051501.38793776
13Non-small cell lung cancer_Homo sapiens_hsa052231.37200164
14Autoimmune thyroid disease_Homo sapiens_hsa053201.36360993
15Phospholipase D signaling pathway_Homo sapiens_hsa040721.35416044
16Graft-versus-host disease_Homo sapiens_hsa053321.34624379
17Allograft rejection_Homo sapiens_hsa053301.34443383
18VEGF signaling pathway_Homo sapiens_hsa043701.33667538
19Phosphatidylinositol signaling system_Homo sapiens_hsa040701.31016602
20Choline metabolism in cancer_Homo sapiens_hsa052311.28843521
21GnRH signaling pathway_Homo sapiens_hsa049121.23399552
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17703296
23Neurotrophin signaling pathway_Homo sapiens_hsa047221.17435359
24Chronic myeloid leukemia_Homo sapiens_hsa052201.17280242
25Tuberculosis_Homo sapiens_hsa051521.16720810
26Toxoplasmosis_Homo sapiens_hsa051451.15839928
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.15787732
28Prolactin signaling pathway_Homo sapiens_hsa049171.10538475
29mTOR signaling pathway_Homo sapiens_hsa041501.09595550
30Chemokine signaling pathway_Homo sapiens_hsa040621.09332644
31Inositol phosphate metabolism_Homo sapiens_hsa005621.07733277
32Endometrial cancer_Homo sapiens_hsa052131.07533969
33Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06503801
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06106718
35Viral myocarditis_Homo sapiens_hsa054161.05852016
36Long-term potentiation_Homo sapiens_hsa047201.05399667
37Platelet activation_Homo sapiens_hsa046111.05021793
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.04169425
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03818205
40Type I diabetes mellitus_Homo sapiens_hsa049401.02850860
41Hematopoietic cell lineage_Homo sapiens_hsa046401.00357842
42Influenza A_Homo sapiens_hsa051640.99758562
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99700341
44Renal cell carcinoma_Homo sapiens_hsa052110.99107262
45ErbB signaling pathway_Homo sapiens_hsa040120.98062513
46Dorso-ventral axis formation_Homo sapiens_hsa043200.97376727
47Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97169197
48Glycosaminoglycan degradation_Homo sapiens_hsa005310.96586692
49Estrogen signaling pathway_Homo sapiens_hsa049150.95044691
50Measles_Homo sapiens_hsa051620.94624889
51Jak-STAT signaling pathway_Homo sapiens_hsa046300.94605631
52Hepatitis C_Homo sapiens_hsa051600.93601961
53Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91607114
54Pancreatic cancer_Homo sapiens_hsa052120.89953652
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88938853
56Glioma_Homo sapiens_hsa052140.86858125
57TNF signaling pathway_Homo sapiens_hsa046680.86198131
58Aldosterone synthesis and secretion_Homo sapiens_hsa049250.85035171
59Malaria_Homo sapiens_hsa051440.84862852
60Intestinal immune network for IgA production_Homo sapiens_hsa046720.84024771
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.82643671
62Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82356193
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81819102
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81292661
65Hepatitis B_Homo sapiens_hsa051610.81120519
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.80672875
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.79862213
68Glycerophospholipid metabolism_Homo sapiens_hsa005640.79455164
69Colorectal cancer_Homo sapiens_hsa052100.78662781
70Endocytosis_Homo sapiens_hsa041440.77387591
71Insulin resistance_Homo sapiens_hsa049310.77273839
72FoxO signaling pathway_Homo sapiens_hsa040680.76002277
73Cholinergic synapse_Homo sapiens_hsa047250.75581487
74MAPK signaling pathway_Homo sapiens_hsa040100.74659229
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.74390344
76Gastric acid secretion_Homo sapiens_hsa049710.73455409
77Insulin signaling pathway_Homo sapiens_hsa049100.72824907
78Rap1 signaling pathway_Homo sapiens_hsa040150.70358329
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69116937
80Oxytocin signaling pathway_Homo sapiens_hsa049210.68499073
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.67572100
82Antigen processing and presentation_Homo sapiens_hsa046120.65925570
83Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.65216377
84Cocaine addiction_Homo sapiens_hsa050300.64710979
85Herpes simplex infection_Homo sapiens_hsa051680.63282376
86Circadian entrainment_Homo sapiens_hsa047130.62451318
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62450327
88ABC transporters_Homo sapiens_hsa020100.62077598
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61937076
90Type II diabetes mellitus_Homo sapiens_hsa049300.61233980
91Amoebiasis_Homo sapiens_hsa051460.60993370
92Ras signaling pathway_Homo sapiens_hsa040140.59274707
93Prostate cancer_Homo sapiens_hsa052150.58840783
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.58637617
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56145798
96Phagosome_Homo sapiens_hsa041450.55373579
97Insulin secretion_Homo sapiens_hsa049110.53886777
98cAMP signaling pathway_Homo sapiens_hsa040240.53707597
99Amphetamine addiction_Homo sapiens_hsa050310.53152754
100Glutamatergic synapse_Homo sapiens_hsa047240.52058787

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