ZNF876P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.14299703
2response to pheromone (GO:0019236)4.13066692
3centriole replication (GO:0007099)4.04628571
4negative regulation of DNA-dependent DNA replication (GO:2000104)3.95469246
5replication fork processing (GO:0031297)3.80921910
6chromatin remodeling at centromere (GO:0031055)3.73534538
7regulation of nuclear cell cycle DNA replication (GO:0033262)3.70757715
8behavioral response to nicotine (GO:0035095)3.69671773
9synapsis (GO:0007129)3.61122536
10regulation of meiosis I (GO:0060631)3.57880717
11CENP-A containing nucleosome assembly (GO:0034080)3.53579485
12protein neddylation (GO:0045116)3.44594725
13somatic hypermutation of immunoglobulin genes (GO:0016446)3.36397274
14somatic diversification of immune receptors via somatic mutation (GO:0002566)3.36397274
15DNA replication checkpoint (GO:0000076)3.29111392
16regulation of mitotic spindle checkpoint (GO:1903504)3.28102092
17regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.28102092
18kinetochore assembly (GO:0051382)3.27668265
19histone exchange (GO:0043486)3.25666035
20negative regulation of telomere maintenance (GO:0032205)3.14974645
21maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.14125840
22protein K6-linked ubiquitination (GO:0085020)3.14118631
23fucose catabolic process (GO:0019317)3.09681545
24L-fucose metabolic process (GO:0042354)3.09681545
25L-fucose catabolic process (GO:0042355)3.09681545
26protein-cofactor linkage (GO:0018065)3.09550664
27cullin deneddylation (GO:0010388)3.07776987
28mitochondrial respiratory chain complex I assembly (GO:0032981)3.05729714
29NADH dehydrogenase complex assembly (GO:0010257)3.05729714
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.05729714
31respiratory chain complex IV assembly (GO:0008535)3.04074905
32protein complex biogenesis (GO:0070271)3.02754070
33kinetochore organization (GO:0051383)3.02160736
34DNA deamination (GO:0045006)3.00964135
35single strand break repair (GO:0000012)2.98266852
36mitochondrial respiratory chain complex assembly (GO:0033108)2.92801025
37proteasome assembly (GO:0043248)2.91508146
38water-soluble vitamin biosynthetic process (GO:0042364)2.90142542
39RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.89486004
40behavioral response to ethanol (GO:0048149)2.89083326
41establishment of protein localization to mitochondrial membrane (GO:0090151)2.87436229
42nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.86424341
43DNA catabolic process, exonucleolytic (GO:0000738)2.84402449
44piRNA metabolic process (GO:0034587)2.83766781
45exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.83040924
46retinal cone cell development (GO:0046549)2.82786832
47recombinational repair (GO:0000725)2.82604940
48negative regulation of DNA recombination (GO:0045910)2.81026771
49double-strand break repair via homologous recombination (GO:0000724)2.79552595
50regulation of helicase activity (GO:0051095)2.78829954
51regulation of telomere maintenance (GO:0032204)2.77599207
52male meiosis (GO:0007140)2.77266604
53transcription elongation from RNA polymerase III promoter (GO:0006385)2.75829413
54termination of RNA polymerase III transcription (GO:0006386)2.75829413
55peptidyl-histidine modification (GO:0018202)2.74406951
56nonmotile primary cilium assembly (GO:0035058)2.74031031
57somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.72676683
58isotype switching (GO:0045190)2.72676683
59somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.72676683
60tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.72056772
61RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.72056772
62protein deneddylation (GO:0000338)2.71504641
63DNA damage response, detection of DNA damage (GO:0042769)2.69775312
64DNA replication-dependent nucleosome assembly (GO:0006335)2.69656934
65DNA replication-dependent nucleosome organization (GO:0034723)2.69656934
66platelet dense granule organization (GO:0060155)2.68187863
67L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.67566348
68resolution of meiotic recombination intermediates (GO:0000712)2.66872797
69centriole assembly (GO:0098534)2.64834564
70reciprocal DNA recombination (GO:0035825)2.63378279
71reciprocal meiotic recombination (GO:0007131)2.63378279
72cytochrome complex assembly (GO:0017004)2.59712083
73DNA replication-independent nucleosome assembly (GO:0006336)2.59104517
74DNA replication-independent nucleosome organization (GO:0034724)2.59104517
75intraciliary transport (GO:0042073)2.54664784
76regulation of translation, ncRNA-mediated (GO:0045974)2.54048881
77negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.54048881
78negative regulation of translation, ncRNA-mediated (GO:0040033)2.54048881
79postreplication repair (GO:0006301)2.52723155
80DNA-dependent DNA replication (GO:0006261)2.51934451
81negative regulation of transcription regulatory region DNA binding (GO:2000678)2.50582082
82DNA ligation (GO:0006266)2.50264126
83tRNA processing (GO:0008033)2.49059906
84epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.46935966
85nucleotide-excision repair, DNA gap filling (GO:0006297)2.46370755
86protein polyglutamylation (GO:0018095)2.45798080
87ubiquinone metabolic process (GO:0006743)2.44249905
88ubiquinone biosynthetic process (GO:0006744)2.44217824
89epithelial cilium movement (GO:0003351)2.43724829
90pseudouridine synthesis (GO:0001522)2.43292974
91regulation of telomere maintenance via telomerase (GO:0032210)2.42226008
92regulation of posttranscriptional gene silencing (GO:0060147)2.42038141
93regulation of gene silencing by miRNA (GO:0060964)2.42038141
94regulation of gene silencing by RNA (GO:0060966)2.42038141
95attachment of spindle microtubules to kinetochore (GO:0008608)2.40896207
96histone H2A acetylation (GO:0043968)2.40307217
97DNA demethylation (GO:0080111)2.38583839
98meiotic chromosome segregation (GO:0045132)2.37602529
99intracellular protein transmembrane import (GO:0044743)2.37552252
100lysine metabolic process (GO:0006553)2.36433381

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ZNF274_21170338_ChIP-Seq_K562_Hela3.78633416
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.30292033
3VDR_22108803_ChIP-Seq_LS180_Human2.97947856
4MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.94168318
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.85800375
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.74316524
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.65437178
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.64802480
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.47010673
10GBX2_23144817_ChIP-Seq_PC3_Human2.41338029
11IGF1R_20145208_ChIP-Seq_DFB_Human2.39160848
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.36264464
13FUS_26573619_Chip-Seq_HEK293_Human2.34632753
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.34362501
15EWS_26573619_Chip-Seq_HEK293_Human2.33060007
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.32918101
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.30932643
18E2F7_22180533_ChIP-Seq_HELA_Human2.27139971
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.26202759
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.17721471
21TAF15_26573619_Chip-Seq_HEK293_Human2.09045239
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07912185
23ELK1_19687146_ChIP-ChIP_HELA_Human2.00075343
24P300_19829295_ChIP-Seq_ESCs_Human1.98820162
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84841264
26MYC_18940864_ChIP-ChIP_HL60_Human1.77250960
27EZH2_22144423_ChIP-Seq_EOC_Human1.69454748
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68948789
29VDR_23849224_ChIP-Seq_CD4+_Human1.68827807
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68156923
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.63928564
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57225642
33IRF1_19129219_ChIP-ChIP_H3396_Human1.53515001
34FOXP3_21729870_ChIP-Seq_TREG_Human1.51348490
35POU5F1_16153702_ChIP-ChIP_HESCs_Human1.49785486
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.49440746
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47158615
38MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43989089
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.43049467
40ER_23166858_ChIP-Seq_MCF-7_Human1.42805084
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.40115772
42GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.37270856
43TP53_22573176_ChIP-Seq_HFKS_Human1.36839760
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36816974
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36805750
46CBP_20019798_ChIP-Seq_JUKART_Human1.36805750
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36042792
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34964415
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34066338
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33826246
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33558153
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.28355723
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27264645
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25558929
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24686877
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24686877
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23269864
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.23200805
59BCAT_22108803_ChIP-Seq_LS180_Human1.23062237
60SMAD4_21799915_ChIP-Seq_A2780_Human1.22877480
61STAT3_23295773_ChIP-Seq_U87_Human1.21662257
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20982259
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18158460
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.18158460
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17326298
66KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16380268
67AR_25329375_ChIP-Seq_VCAP_Human1.16143303
68NANOG_19829295_ChIP-Seq_ESCs_Human1.15038649
69SOX2_19829295_ChIP-Seq_ESCs_Human1.15038649
70SOX2_16153702_ChIP-ChIP_HESCs_Human1.14641687
71TCF4_22108803_ChIP-Seq_LS180_Human1.14199774
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.14057510
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13322566
74KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.10550730
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10215970
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09903778
77TCF4_23295773_ChIP-Seq_U87_Human1.09634102
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.09081757
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09042532
80TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07547715
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.05512758
82RUNX2_22187159_ChIP-Seq_PCA_Human1.05360265
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04450366
84HTT_18923047_ChIP-ChIP_STHdh_Human1.02978686
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02926984
86PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02209370
87FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.01185025
88NANOG_16153702_ChIP-ChIP_HESCs_Human1.01145411
89RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99364220
90FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99281690
91SMAD4_21741376_ChIP-Seq_EPCs_Human0.95396092
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95359565
93NCOR_22424771_ChIP-Seq_293T_Human0.95044195
94RNF2_27304074_Chip-Seq_NSC_Mouse0.95012880
95AR_20517297_ChIP-Seq_VCAP_Human0.94958019
96CRX_20693478_ChIP-Seq_RETINA_Mouse0.94200875
97YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94073735
98RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93791542
99FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93173155
100NANOG_18555785_Chip-Seq_ESCs_Mouse0.90518754

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.40127925
2MP0008058_abnormal_DNA_repair3.04693970
3MP0006292_abnormal_olfactory_placode2.84455712
4MP0003787_abnormal_imprinting2.73735395
5MP0002102_abnormal_ear_morphology2.63397968
6MP0010094_abnormal_chromosome_stability2.57352796
7MP0008057_abnormal_DNA_replication2.34137341
8MP0006072_abnormal_retinal_apoptosis2.31834378
9MP0003693_abnormal_embryo_hatching2.23583706
10MP0003195_calcinosis2.21283261
11MP0003718_maternal_effect2.00290350
12MP0003121_genomic_imprinting1.99252979
13MP0003880_abnormal_central_pattern1.97055657
14MP0002736_abnormal_nociception_after1.93387972
15MP0005551_abnormal_eye_electrophysiolog1.92440290
16MP0001188_hyperpigmentation1.91503814
17MP0003890_abnormal_embryonic-extraembry1.88731612
18MP0005253_abnormal_eye_physiology1.85309792
19MP0003136_yellow_coat_color1.80170638
20MP0008789_abnormal_olfactory_epithelium1.77933632
21MP0006276_abnormal_autonomic_nervous1.71308632
22MP0001968_abnormal_touch/_nociception1.66724312
23MP0002938_white_spotting1.63350725
24MP0001529_abnormal_vocalization1.61409210
25MP0003122_maternal_imprinting1.60380082
26MP0001293_anophthalmia1.59787893
27MP0004147_increased_porphyrin_level1.59080315
28MP0002638_abnormal_pupillary_reflex1.56990925
29MP0009046_muscle_twitch1.54672469
30MP0003111_abnormal_nucleus_morphology1.52562267
31MP0001984_abnormal_olfaction1.49326131
32MP0005646_abnormal_pituitary_gland1.46305564
33MP0005394_taste/olfaction_phenotype1.43655822
34MP0005499_abnormal_olfactory_system1.43655822
35MP0000427_abnormal_hair_cycle1.42078203
36MP0005084_abnormal_gallbladder_morpholo1.39745439
37MP0009745_abnormal_behavioral_response1.36541695
38MP0002837_dystrophic_cardiac_calcinosis1.36054969
39MP0001986_abnormal_taste_sensitivity1.34559599
40MP0003119_abnormal_digestive_system1.33672696
41MP0000631_abnormal_neuroendocrine_gland1.33154170
42MP0001929_abnormal_gametogenesis1.31375087
43MP0000647_abnormal_sebaceous_gland1.30176199
44MP0004957_abnormal_blastocyst_morpholog1.28733266
45MP0003786_premature_aging1.28679282
46MP0002272_abnormal_nervous_system1.27175578
47MP0002234_abnormal_pharynx_morphology1.26581356
48MP0008872_abnormal_physiological_respon1.25431923
49MP0003011_delayed_dark_adaptation1.24078630
50MP0004142_abnormal_muscle_tone1.23950379
51MP0004133_heterotaxia1.21625551
52MP0002210_abnormal_sex_determination1.21208433
53MP0004215_abnormal_myocardial_fiber1.19393141
54MP0003567_abnormal_fetal_cardiomyocyte1.19017253
55MP0005645_abnormal_hypothalamus_physiol1.15835609
56MP0003937_abnormal_limbs/digits/tail_de1.14282817
57MP0002751_abnormal_autonomic_nervous1.14189492
58MP0000372_irregular_coat_pigmentation1.13998621
59MP0006035_abnormal_mitochondrial_morpho1.10826331
60MP0004043_abnormal_pH_regulation1.08826232
61MP0002735_abnormal_chemical_nociception1.08791797
62MP0001486_abnormal_startle_reflex1.06474401
63MP0001485_abnormal_pinna_reflex1.06055388
64MP0004885_abnormal_endolymph1.05889650
65MP0000569_abnormal_digit_pigmentation1.04913857
66MP0008007_abnormal_cellular_replicative1.04766046
67MP0008932_abnormal_embryonic_tissue1.03139202
68MP0003698_abnormal_male_reproductive1.03063584
69MP0002160_abnormal_reproductive_system1.01419426
70MP0003077_abnormal_cell_cycle1.01211892
71MP0005389_reproductive_system_phenotype1.00520164
72MP0001919_abnormal_reproductive_system1.00512954
73MP0000653_abnormal_sex_gland1.00444531
74MP0002557_abnormal_social/conspecific_i0.99115441
75MP0001145_abnormal_male_reproductive0.98584725
76MP0002233_abnormal_nose_morphology0.98289970
77MP0006036_abnormal_mitochondrial_physio0.96745119
78MP0002572_abnormal_emotion/affect_behav0.95813084
79MP0008995_early_reproductive_senescence0.94456779
80MP0001764_abnormal_homeostasis0.94151908
81MP0005410_abnormal_fertilization0.93279295
82MP0002254_reproductive_system_inflammat0.93070740
83MP0003941_abnormal_skin_development0.92291050
84MP0002734_abnormal_mechanical_nocicepti0.90681505
85MP0005075_abnormal_melanosome_morpholog0.90064428
86MP0005377_hearing/vestibular/ear_phenot0.89856778
87MP0003878_abnormal_ear_physiology0.89856778
88MP0010386_abnormal_urinary_bladder0.88443500
89MP0002653_abnormal_ependyma_morphology0.87664418
90MP0005391_vision/eye_phenotype0.87531260
91MP0000778_abnormal_nervous_system0.86115745
92MP0005195_abnormal_posterior_eye0.85216908
93MP0004145_abnormal_muscle_electrophysio0.85089276
94MP0002067_abnormal_sensory_capabilities0.82731442
95MP0002822_catalepsy0.82020231
96MP0000049_abnormal_middle_ear0.79104043
97MP0002752_abnormal_somatic_nervous0.78989042
98MP0002184_abnormal_innervation0.77900586
99MP0003646_muscle_fatigue0.76743274
100MP0001501_abnormal_sleep_pattern0.74351597

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.65303448
2Colon cancer (HP:0003003)3.64308258
3Abnormality of the labia minora (HP:0012880)3.56362936
4Abnormality of midbrain morphology (HP:0002418)3.51220782
5Molar tooth sign on MRI (HP:0002419)3.51220782
6Pancreatic fibrosis (HP:0100732)3.23246188
7True hermaphroditism (HP:0010459)3.13896969
8Progressive inability to walk (HP:0002505)3.00534215
9Nephronophthisis (HP:0000090)2.85572215
10Congenital stationary night blindness (HP:0007642)2.82922043
11Methylmalonic acidemia (HP:0002912)2.81464117
12Aplasia/Hypoplasia of the uvula (HP:0010293)2.75172209
13Medial flaring of the eyebrow (HP:0010747)2.70088860
14Acute necrotizing encephalopathy (HP:0006965)2.65436049
15Meckel diverticulum (HP:0002245)2.64114782
16Inability to walk (HP:0002540)2.62652267
17Abolished electroretinogram (ERG) (HP:0000550)2.62053334
18Chromosomal breakage induced by crosslinking agents (HP:0003221)2.57752996
19Abnormality of the ileum (HP:0001549)2.55693083
20Abnormal biliary tract physiology (HP:0012439)2.51936479
21Bile duct proliferation (HP:0001408)2.51936479
22Hyperglycinemia (HP:0002154)2.44017953
233-Methylglutaconic aciduria (HP:0003535)2.42793187
24Chromsome breakage (HP:0040012)2.42702295
25Abnormality of the renal medulla (HP:0100957)2.42375344
26Abnormality of chromosome stability (HP:0003220)2.41149176
27Acute encephalopathy (HP:0006846)2.37900057
28Hyperglycinuria (HP:0003108)2.34347950
29Increased CSF lactate (HP:0002490)2.30588699
30Chronic hepatic failure (HP:0100626)2.29690908
31Abnormality of glycine metabolism (HP:0010895)2.28619584
32Abnormality of serine family amino acid metabolism (HP:0010894)2.28619584
33Abnormality of the renal cortex (HP:0011035)2.28579719
34Progressive macrocephaly (HP:0004481)2.27225311
35Sloping forehead (HP:0000340)2.26878742
36Birth length less than 3rd percentile (HP:0003561)2.24969048
37Increased hepatocellular lipid droplets (HP:0006565)2.19026447
38Mitochondrial inheritance (HP:0001427)2.18224201
39Gait imbalance (HP:0002141)2.15505856
40Abnormal mitochondria in muscle tissue (HP:0008316)2.15174341
41Congenital primary aphakia (HP:0007707)2.13968441
42Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.13572363
43Methylmalonic aciduria (HP:0012120)2.11233516
44Abnormality of alanine metabolism (HP:0010916)2.10252192
45Hyperalaninemia (HP:0003348)2.10252192
46Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.10252192
47Lipid accumulation in hepatocytes (HP:0006561)2.08987380
48Cystic liver disease (HP:0006706)2.07044811
49Abnormal hair whorl (HP:0010721)2.07028284
50Type II lissencephaly (HP:0007260)2.06179371
51Renal cortical cysts (HP:0000803)2.04825461
52Pendular nystagmus (HP:0012043)1.99694765
53Optic nerve hypoplasia (HP:0000609)1.98506633
54Aplasia/Hypoplasia of the tongue (HP:0010295)1.98238606
55Volvulus (HP:0002580)1.98036094
56Nephrogenic diabetes insipidus (HP:0009806)1.97464086
57Abnormality of the preputium (HP:0100587)1.97410638
58Sclerocornea (HP:0000647)1.96170708
59Lissencephaly (HP:0001339)1.94613271
60Abnormality of serum amino acid levels (HP:0003112)1.92989015
61Anencephaly (HP:0002323)1.90953071
62Genital tract atresia (HP:0001827)1.89662576
63Small intestinal stenosis (HP:0012848)1.88433032
64Duodenal stenosis (HP:0100867)1.88433032
65Ependymoma (HP:0002888)1.88178345
66Attenuation of retinal blood vessels (HP:0007843)1.86547922
67Abnormal lung lobation (HP:0002101)1.85940380
68Intestinal atresia (HP:0011100)1.85850532
69Hepatocellular necrosis (HP:0001404)1.85729666
70Cortical dysplasia (HP:0002539)1.85578317
71Retinal dysplasia (HP:0007973)1.84968306
72Supernumerary spleens (HP:0009799)1.84769765
73Glioma (HP:0009733)1.84276474
74Abnormality of aspartate family amino acid metabolism (HP:0010899)1.83129515
75Vaginal atresia (HP:0000148)1.82463540
76Preaxial hand polydactyly (HP:0001177)1.81944911
77Stomach cancer (HP:0012126)1.81477204
78Aplasia/Hypoplasia of the tibia (HP:0005772)1.80366259
79Abnormality of the duodenum (HP:0002246)1.79990770
80Postaxial foot polydactyly (HP:0001830)1.79741724
81Oligodactyly (hands) (HP:0001180)1.79219246
82Ectopic kidney (HP:0000086)1.78778047
83Optic disc pallor (HP:0000543)1.77729881
84Dandy-Walker malformation (HP:0001305)1.77612117
85Clubbing of toes (HP:0100760)1.74807306
86Abnormality of vitamin B metabolism (HP:0004340)1.74659832
87Hypomagnesemia (HP:0002917)1.74115054
88Increased serum lactate (HP:0002151)1.74018447
89Triphalangeal thumb (HP:0001199)1.73425320
90Median cleft lip (HP:0000161)1.73131892
91Pancreatic islet-cell hyperplasia (HP:0004510)1.72581399
92Abnormality of the carotid arteries (HP:0005344)1.72550980
93Renal Fanconi syndrome (HP:0001994)1.72400620
94Hepatic necrosis (HP:0002605)1.71932858
95Cerebral edema (HP:0002181)1.70914790
96Abnormality of the vitamin B12 metabolism (HP:0004341)1.70825854
97Congenital hepatic fibrosis (HP:0002612)1.69441321
98Astigmatism (HP:0000483)1.68352919
99Septo-optic dysplasia (HP:0100842)1.66840102
100Postaxial hand polydactyly (HP:0001162)1.66771158

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR1B4.09679819
2WNK33.27527511
3ZAK3.17363633
4MAP4K23.02084925
5FRK2.63643933
6TRIM282.50412233
7ACVR1B2.36550175
8PLK42.12259584
9NUAK12.09298231
10PINK11.97534819
11MAP3K41.95139755
12TNIK1.93834224
13ADRBK21.88453467
14BUB11.84605091
15GRK11.84178809
16MAPK131.81390216
17MST41.79542882
18TSSK61.76796641
19CDC71.69987587
20MKNK21.66107311
21TTK1.64306409
22PLK31.55483801
23CASK1.54729747
24SRPK11.37519422
25DYRK21.35314555
26MKNK11.33561017
27MUSK1.33325629
28OXSR11.32613213
29EIF2AK31.32120079
30WNK41.31910435
31MAP2K71.30184150
32BRSK21.28544240
33WEE11.21699142
34PLK11.19429416
35INSRR1.18816794
36NEK11.17939047
37VRK11.17908961
38VRK21.11294913
39BCR1.09922968
40NME11.09033242
41PNCK1.03533019
42PLK21.01424335
43TGFBR10.99928134
44TAOK30.98477617
45ATR0.97222951
46TIE10.96057344
47CDK190.95841585
48STK390.94787711
49STK160.93444755
50CSNK1G10.86161731
51PAK30.85157550
52PRKCG0.83905516
53CSNK1G20.79668446
54STK38L0.79054667
55CHEK20.78048349
56PRKCE0.77961263
57TLK10.77498382
58DYRK30.75667230
59TXK0.73867341
60CSNK1G30.72916925
61EPHA40.72818787
62BCKDK0.70205464
63RPS6KA40.69943271
64ERBB30.69901384
65STK30.68303219
66PASK0.67406569
67ATM0.64780009
68DAPK20.64644486
69PBK0.63096640
70TAF10.57629217
71MARK10.57128061
72CDK30.57020708
73AKT30.53404268
74FLT30.51778333
75TEC0.50981658
76CSNK1A1L0.49834937
77NEK20.46913526
78AURKB0.45535278
79MINK10.43029558
80ADRBK10.40678582
81EIF2AK20.40276698
82PKN10.37720442
83NTRK30.37717061
84CAMK2A0.35432446
85BRSK10.34466920
86NTRK20.34426513
87CSNK1A10.34035333
88PRKACA0.32886522
89CSNK2A10.31709290
90PDK20.31545015
91CSNK1D0.31500663
92PRKACB0.29957373
93RPS6KA50.29636508
94CHEK10.29555835
95DYRK1A0.29194868
96FGFR20.29062157
97PRKDC0.28784070
98PRKG10.28072183
99OBSCN0.27738146
100AURKA0.25931684

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034402.86958587
2Non-homologous end-joining_Homo sapiens_hsa034502.83712138
3Mismatch repair_Homo sapiens_hsa034302.75275807
4RNA polymerase_Homo sapiens_hsa030202.70665363
5Fanconi anemia pathway_Homo sapiens_hsa034602.59372597
6Protein export_Homo sapiens_hsa030602.53315097
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.37461671
8Phototransduction_Homo sapiens_hsa047442.25616019
9Proteasome_Homo sapiens_hsa030502.16489922
10Oxidative phosphorylation_Homo sapiens_hsa001902.15843555
11Basal transcription factors_Homo sapiens_hsa030222.14689168
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.09708725
13Selenocompound metabolism_Homo sapiens_hsa004502.02515105
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.98958512
15Propanoate metabolism_Homo sapiens_hsa006401.92258737
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.92056647
17DNA replication_Homo sapiens_hsa030301.91080327
18One carbon pool by folate_Homo sapiens_hsa006701.85343807
19Parkinsons disease_Homo sapiens_hsa050121.85065687
20RNA degradation_Homo sapiens_hsa030181.84668129
21Butanoate metabolism_Homo sapiens_hsa006501.78011420
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.66224448
23Base excision repair_Homo sapiens_hsa034101.64848944
24Steroid biosynthesis_Homo sapiens_hsa001001.59160724
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.58437130
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55620336
27Nicotine addiction_Homo sapiens_hsa050331.53861902
28Linoleic acid metabolism_Homo sapiens_hsa005911.49461180
29Nucleotide excision repair_Homo sapiens_hsa034201.46051946
30RNA transport_Homo sapiens_hsa030131.45312407
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38832999
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.35670888
33Purine metabolism_Homo sapiens_hsa002301.29414547
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29207411
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.29193870
36Huntingtons disease_Homo sapiens_hsa050161.27723053
37Nitrogen metabolism_Homo sapiens_hsa009101.27243257
38Pyrimidine metabolism_Homo sapiens_hsa002401.26638303
39Ether lipid metabolism_Homo sapiens_hsa005651.25252094
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.23088301
41Caffeine metabolism_Homo sapiens_hsa002321.22839888
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.21558465
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19425612
44Spliceosome_Homo sapiens_hsa030401.15833992
45Fatty acid elongation_Homo sapiens_hsa000621.13937566
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.12925155
47Cell cycle_Homo sapiens_hsa041101.05562946
48Peroxisome_Homo sapiens_hsa041461.04324484
49Tryptophan metabolism_Homo sapiens_hsa003800.98682608
50Taste transduction_Homo sapiens_hsa047420.92481454
51Primary bile acid biosynthesis_Homo sapiens_hsa001200.90778710
52Olfactory transduction_Homo sapiens_hsa047400.90342288
53Alzheimers disease_Homo sapiens_hsa050100.90142734
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87390738
55Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84913897
56Cardiac muscle contraction_Homo sapiens_hsa042600.83244803
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79322430
58Collecting duct acid secretion_Homo sapiens_hsa049660.79158324
59Metabolic pathways_Homo sapiens_hsa011000.74203641
60Oocyte meiosis_Homo sapiens_hsa041140.72300699
61Folate biosynthesis_Homo sapiens_hsa007900.70829874
62Morphine addiction_Homo sapiens_hsa050320.68650788
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68489902
64Regulation of autophagy_Homo sapiens_hsa041400.66923633
65Ribosome_Homo sapiens_hsa030100.65990411
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64740860
67Arachidonic acid metabolism_Homo sapiens_hsa005900.64683271
68beta-Alanine metabolism_Homo sapiens_hsa004100.64663834
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64006004
70GABAergic synapse_Homo sapiens_hsa047270.63895104
71Retinol metabolism_Homo sapiens_hsa008300.62247828
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61849943
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58839821
74Circadian rhythm_Homo sapiens_hsa047100.58699854
75mRNA surveillance pathway_Homo sapiens_hsa030150.58002277
76Serotonergic synapse_Homo sapiens_hsa047260.57928177
77Chemical carcinogenesis_Homo sapiens_hsa052040.56476448
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55630570
79Pyruvate metabolism_Homo sapiens_hsa006200.55160978
80Glutathione metabolism_Homo sapiens_hsa004800.52094388
81Circadian entrainment_Homo sapiens_hsa047130.50908968
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48025969
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47579949
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.47050198
85Insulin secretion_Homo sapiens_hsa049110.46267196
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45435627
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.42643688
88p53 signaling pathway_Homo sapiens_hsa041150.41030373
89Basal cell carcinoma_Homo sapiens_hsa052170.39983482
90Fatty acid degradation_Homo sapiens_hsa000710.38922613
91Vitamin B6 metabolism_Homo sapiens_hsa007500.38514283
92Ovarian steroidogenesis_Homo sapiens_hsa049130.37953004
93Fatty acid metabolism_Homo sapiens_hsa012120.37920289
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37677794
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37056273
96Glutamatergic synapse_Homo sapiens_hsa047240.36705156
97Long-term depression_Homo sapiens_hsa047300.36547526
98Sulfur metabolism_Homo sapiens_hsa009200.36369984
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34802777
100Hedgehog signaling pathway_Homo sapiens_hsa043400.33576964

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