ZNF878

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of retinoic acid receptor signaling pathway (GO:0048387)7.83873364
2regulation of retinoic acid receptor signaling pathway (GO:0048385)6.93211860
3neurotransmitter catabolic process (GO:0042135)5.26386123
4neurofilament cytoskeleton organization (GO:0060052)5.09499108
5replication fork processing (GO:0031297)4.79391984
6negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.67147033
7positive regulation of amino acid transport (GO:0051957)4.63548478
8establishment of integrated proviral latency (GO:0075713)4.61948712
9DNA strand renaturation (GO:0000733)4.46187539
10chromatin remodeling at centromere (GO:0031055)4.36134568
11CENP-A containing nucleosome assembly (GO:0034080)4.28956388
12protein localization to kinetochore (GO:0034501)4.22171242
13DNA replication checkpoint (GO:0000076)4.17052310
14DNA replication-dependent nucleosome organization (GO:0034723)4.13140005
15DNA replication-dependent nucleosome assembly (GO:0006335)4.13140005
16somatic diversification of immune receptors via somatic mutation (GO:0002566)4.11325535
17somatic hypermutation of immunoglobulin genes (GO:0016446)4.11325535
18nuclear pore complex assembly (GO:0051292)4.06838872
19ribosome assembly (GO:0042255)4.02307733
20negative regulation of DNA-dependent DNA replication (GO:2000104)4.02226404
21positive regulation of synaptic transmission, GABAergic (GO:0032230)4.01727634
22DNA strand elongation involved in DNA replication (GO:0006271)4.01603006
23maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.00343608
24DNA double-strand break processing (GO:0000729)3.94219567
25DNA replication-independent nucleosome organization (GO:0034724)3.85829018
26DNA replication-independent nucleosome assembly (GO:0006336)3.85829018
27mitotic sister chromatid segregation (GO:0000070)3.85489217
28proteasome assembly (GO:0043248)3.84404196
29DNA strand elongation (GO:0022616)3.83333930
30histone exchange (GO:0043486)3.81195008
31nuclear pore organization (GO:0006999)3.77270103
32sister chromatid segregation (GO:0000819)3.75996526
33somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.70119343
34somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.70119343
35isotype switching (GO:0045190)3.70119343
36regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.69524040
37kinetochore organization (GO:0051383)3.63529434
38negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.63319421
39negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.63319421
40negative regulation of mitotic sister chromatid segregation (GO:0033048)3.63319421
41negative regulation of mitotic sister chromatid separation (GO:2000816)3.63319421
42negative regulation of sister chromatid segregation (GO:0033046)3.63319421
43negative regulation of DNA recombination (GO:0045910)3.60884352
44spindle checkpoint (GO:0031577)3.60561161
45telomere maintenance via semi-conservative replication (GO:0032201)3.59920005
46negative regulation of chromosome segregation (GO:0051985)3.58103024
47non-recombinational repair (GO:0000726)3.56918003
48double-strand break repair via nonhomologous end joining (GO:0006303)3.56918003
49protein localization to chromosome, centromeric region (GO:0071459)3.55724648
50mitotic metaphase plate congression (GO:0007080)3.51907544
51mitotic spindle checkpoint (GO:0071174)3.51338534
52regulation of mitotic metaphase/anaphase transition (GO:0030071)3.51152030
53regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.51152030
54nucleotide-excision repair, DNA gap filling (GO:0006297)3.50547043
55DNA ligation (GO:0006266)3.42030366
56establishment of viral latency (GO:0019043)3.41734474
57mitotic chromosome condensation (GO:0007076)3.40931447
58DNA unwinding involved in DNA replication (GO:0006268)3.38171047
59regulation of DNA methylation (GO:0044030)3.37612547
60regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.34423071
61intra-S DNA damage checkpoint (GO:0031573)3.32518945
62postreplication repair (GO:0006301)3.32216798
63regulation of sister chromatid segregation (GO:0033045)3.32072098
64regulation of mitotic sister chromatid separation (GO:0010965)3.32072098
65regulation of mitotic sister chromatid segregation (GO:0033047)3.32072098
66negative regulation of mRNA processing (GO:0050686)3.30459936
67mitotic recombination (GO:0006312)3.30312930
68somatic recombination of immunoglobulin gene segments (GO:0016447)3.29957974
69regulation of chromosome segregation (GO:0051983)3.29656183
70mitotic spindle assembly checkpoint (GO:0007094)3.28280782
71DNA replication initiation (GO:0006270)3.27205044
72DNA catabolic process, exonucleolytic (GO:0000738)3.25287772
73spindle assembly checkpoint (GO:0071173)3.22333799
74metaphase plate congression (GO:0051310)3.21808268
75exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.17336654
76regulation of helicase activity (GO:0051095)3.15421691
77response to X-ray (GO:0010165)3.13929500
78translesion synthesis (GO:0019985)3.13079997
79telomere maintenance via recombination (GO:0000722)3.12067503
80mitotic nuclear envelope disassembly (GO:0007077)3.10150910
81pore complex assembly (GO:0046931)3.09111995
82regulation of centriole replication (GO:0046599)3.08709976
83regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.08453205
84telomere maintenance via telomere lengthening (GO:0010833)3.08089029
85IMP biosynthetic process (GO:0006188)3.07800573
86attachment of spindle microtubules to kinetochore (GO:0008608)3.05149191
87nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.05097243
88DNA damage response, detection of DNA damage (GO:0042769)3.02876960
89kinetochore assembly (GO:0051382)3.02072429
90DNA topological change (GO:0006265)2.99520884
91positive regulation of chromosome segregation (GO:0051984)2.97921252
92ribosomal large subunit biogenesis (GO:0042273)2.96433422
93RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.95510763
94negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.94586558
95membrane disassembly (GO:0030397)2.93367981
96nuclear envelope disassembly (GO:0051081)2.93367981
97regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.91234591
98somatic diversification of immunoglobulins (GO:0016445)2.90856640
99histone H2A acetylation (GO:0043968)2.90721407
100protein K6-linked ubiquitination (GO:0085020)2.89992619

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.14676380
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.47454030
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.16282829
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.72999332
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.43076401
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.31369762
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.21737738
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.18221424
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.89440686
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.76623170
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.60322140
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.57168104
13AR_21909140_ChIP-Seq_LNCAP_Human2.56759351
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.48235025
15GBX2_23144817_ChIP-Seq_PC3_Human2.42843359
16IRF1_19129219_ChIP-ChIP_H3396_Human2.41626177
17KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.40623504
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.36021057
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.25399670
20ELK1_19687146_ChIP-ChIP_HELA_Human2.16145922
21E2F1_21310950_ChIP-Seq_MCF-7_Human2.15255841
22POU5F1_16153702_ChIP-ChIP_HESCs_Human2.14217379
23NOTCH1_21737748_ChIP-Seq_TLL_Human1.99747902
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.98797124
25EWS_26573619_Chip-Seq_HEK293_Human1.86093849
26FUS_26573619_Chip-Seq_HEK293_Human1.84401854
27SOX2_16153702_ChIP-ChIP_HESCs_Human1.79309820
28MYC_19030024_ChIP-ChIP_MESCs_Mouse1.79164201
29TAF15_26573619_Chip-Seq_HEK293_Human1.78111737
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77345444
31NANOG_16153702_ChIP-ChIP_HESCs_Human1.77220196
32HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.75718198
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75696357
34* ZNF274_21170338_ChIP-Seq_K562_Hela1.73215849
35MYC_19079543_ChIP-ChIP_MESCs_Mouse1.73198699
36KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.69011642
37KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.69011642
38KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.69011642
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.67563161
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60471756
41VDR_23849224_ChIP-Seq_CD4+_Human1.56688151
42MYC_18940864_ChIP-ChIP_HL60_Human1.49689646
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48420167
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.47614167
45TP63_19390658_ChIP-ChIP_HaCaT_Human1.46999909
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.46508546
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43878089
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43502957
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.42143175
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41957485
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.41673991
52TTF2_22483619_ChIP-Seq_HELA_Human1.41446607
53NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.41283611
54DCP1A_22483619_ChIP-Seq_HELA_Human1.38495266
55FOXP3_21729870_ChIP-Seq_TREG_Human1.32150641
56VDR_22108803_ChIP-Seq_LS180_Human1.30243780
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27708052
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26430499
59P300_19829295_ChIP-Seq_ESCs_Human1.24715243
60DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.23889393
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18981347
62SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.18725173
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15646203
64MYCN_18555785_ChIP-Seq_MESCs_Mouse1.13899480
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12995920
66MYC_18358816_ChIP-ChIP_MESCs_Mouse1.12454609
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11435930
68RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08563165
69E2F1_18555785_ChIP-Seq_MESCs_Mouse1.07094611
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01271968
71JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.01133352
72NANOG_18555785_ChIP-Seq_MESCs_Mouse0.98695374
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96611892
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95366996
75XRN2_22483619_ChIP-Seq_HELA_Human0.95058789
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93664743
77THAP11_20581084_ChIP-Seq_MESCs_Mouse0.93111475
78BCAT_22108803_ChIP-Seq_LS180_Human0.91204370
79ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91057707
80SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90984209
81POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.89992648
82E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.86733978
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85580227
84PCGF2_27294783_Chip-Seq_NPCs_Mouse0.85408446
85POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.85144856
86FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.83571084
87CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.83501885
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82485540
89SOX9_26525672_Chip-Seq_HEART_Mouse0.82360778
90PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.81956669
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.80657822
92EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.80475407
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.79777534
94CTBP1_25329375_ChIP-Seq_LNCAP_Human0.78469535
95EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.78049700
96CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.78010989
97STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.77933424
98SUZ12_27294783_Chip-Seq_NPCs_Mouse0.77197869
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.76881113
100GATA1_26923725_Chip-Seq_HPCs_Mouse0.75604946

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.81242581
2MP0008057_abnormal_DNA_replication4.80564577
3MP0008058_abnormal_DNA_repair3.97332797
4MP0002735_abnormal_chemical_nociception3.93200776
5MP0003111_abnormal_nucleus_morphology3.38652049
6MP0004957_abnormal_blastocyst_morpholog3.12542730
7MP0003941_abnormal_skin_development3.08714229
8MP0003693_abnormal_embryo_hatching3.08679353
9MP0003077_abnormal_cell_cycle2.89374217
10MP0008877_abnormal_DNA_methylation2.70344184
11MP0002638_abnormal_pupillary_reflex2.61185483
12MP0008007_abnormal_cellular_replicative2.56200044
13MP0003890_abnormal_embryonic-extraembry2.45959094
14MP0000537_abnormal_urethra_morphology2.43284635
15MP0008932_abnormal_embryonic_tissue2.40063792
16MP0003718_maternal_effect2.30422804
17MP0010307_abnormal_tumor_latency2.17281916
18MP0003121_genomic_imprinting1.99598105
19MP0002254_reproductive_system_inflammat1.93023130
20MP0001730_embryonic_growth_arrest1.92102454
21MP0003787_abnormal_imprinting1.65530431
22MP0009697_abnormal_copulation1.58037715
23MP0006292_abnormal_olfactory_placode1.56334750
24MP0000350_abnormal_cell_proliferation1.53896291
25MP0006035_abnormal_mitochondrial_morpho1.53785530
26MP0009672_abnormal_birth_weight1.48150220
27MP0005076_abnormal_cell_differentiation1.43168863
28MP0003119_abnormal_digestive_system1.39175486
29MP0001697_abnormal_embryo_size1.38273349
30MP0001346_abnormal_lacrimal_gland1.36029116
31MP0001672_abnormal_embryogenesis/_devel1.34289024
32MP0005380_embryogenesis_phenotype1.34289024
33MP0003122_maternal_imprinting1.33377806
34MP0001286_abnormal_eye_development1.27100442
35MP0010352_gastrointestinal_tract_polyps1.25000617
36MP0003221_abnormal_cardiomyocyte_apopto1.24520991
37MP0005367_renal/urinary_system_phenotyp1.23609763
38MP0000516_abnormal_urinary_system1.23609763
39MP0002085_abnormal_embryonic_tissue1.22152274
40MP0001529_abnormal_vocalization1.21832079
41MP0003786_premature_aging1.21276749
42MP0000647_abnormal_sebaceous_gland1.20663104
43MP0002396_abnormal_hematopoietic_system1.19791460
44MP0002084_abnormal_developmental_patter1.18546384
45MP0009703_decreased_birth_body1.16638994
46MP0003937_abnormal_limbs/digits/tail_de1.15451196
47MP0001929_abnormal_gametogenesis1.15099791
48MP0002210_abnormal_sex_determination1.14443800
49MP0003123_paternal_imprinting1.13113939
50MP0004197_abnormal_fetal_growth/weight/1.11671903
51MP0010386_abnormal_urinary_bladder1.11390055
52MP0001293_anophthalmia1.11297065
53MP0004215_abnormal_myocardial_fiber1.10543600
54MP0003984_embryonic_growth_retardation1.07497621
55MP0002088_abnormal_embryonic_growth/wei1.06832173
56MP0006036_abnormal_mitochondrial_physio1.05984410
57MP0002080_prenatal_lethality1.04050839
58MP0001986_abnormal_taste_sensitivity1.03895479
59MP0001666_abnormal_nutrient_absorption1.02337221
60MP0002697_abnormal_eye_size1.02285152
61MP0000313_abnormal_cell_death0.99688610
62MP0001486_abnormal_startle_reflex0.97790226
63MP0003646_muscle_fatigue0.96766177
64MP0002163_abnormal_gland_morphology0.96534729
65MP0002233_abnormal_nose_morphology0.96403641
66MP0001145_abnormal_male_reproductive0.94915232
67MP0000653_abnormal_sex_gland0.93673733
68MP0003567_abnormal_fetal_cardiomyocyte0.91423141
69MP0001188_hyperpigmentation0.89853791
70MP0002111_abnormal_tail_morphology0.87101720
71MP0002751_abnormal_autonomic_nervous0.82361073
72MP0006072_abnormal_retinal_apoptosis0.81037920
73MP0003861_abnormal_nervous_system0.80983434
74MP0003755_abnormal_palate_morphology0.80765849
75MP0008873_increased_physiological_sensi0.78547713
76MP0010030_abnormal_orbit_morphology0.78365179
77MP0001177_atelectasis0.77250300
78MP0002938_white_spotting0.76364122
79MP0002086_abnormal_extraembryonic_tissu0.76077935
80MP0005395_other_phenotype0.74859504
81MP0000428_abnormal_craniofacial_morphol0.72056556
82MP0003699_abnormal_female_reproductive0.70926541
83MP0001970_abnormal_pain_threshold0.69961338
84MP0003698_abnormal_male_reproductive0.68757564
85MP0002736_abnormal_nociception_after0.68362595
86MP0001119_abnormal_female_reproductive0.66239034
87MP0009379_abnormal_foot_pigmentation0.66176035
88MP0009250_abnormal_appendicular_skeleto0.65960788
89MP0002090_abnormal_vision0.65934125
90MP0002282_abnormal_trachea_morphology0.65069183
91MP0006276_abnormal_autonomic_nervous0.63920918
92MP0000358_abnormal_cell_content/0.63794033
93MP0000427_abnormal_hair_cycle0.63505161
94MP0002102_abnormal_ear_morphology0.62050369
95MP0003935_abnormal_craniofacial_develop0.61350501
96MP0002161_abnormal_fertility/fecundity0.60627375
97MP0008995_early_reproductive_senescence0.59975433
98MP0004133_heterotaxia0.59722948
99MP0002081_perinatal_lethality0.58051510
100MP0000579_abnormal_nail_morphology0.57036187

Predicted human phenotypes

RankGene SetZ-score
1Ulnar claw (HP:0001178)5.93303117
2Birth length less than 3rd percentile (HP:0003561)4.83780011
3Colon cancer (HP:0003003)4.37528981
4Abnormality of the labia minora (HP:0012880)4.19369620
5Ependymoma (HP:0002888)4.01947503
6Segmental peripheral demyelination/remyelination (HP:0003481)3.95047170
7Agnosia (HP:0010524)3.80013513
8Abnormality of chromosome stability (HP:0003220)3.77715665
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.67455378
10Meckel diverticulum (HP:0002245)3.65156319
11Volvulus (HP:0002580)3.59245498
12Abnormality of the ileum (HP:0001549)3.57450567
13Aplasia/Hypoplasia of the uvula (HP:0010293)3.50853277
14Abnormality of the preputium (HP:0100587)3.26258145
15Chromsome breakage (HP:0040012)3.23482494
16Type 2 muscle fiber atrophy (HP:0003554)3.14912399
17Rhabdomyosarcoma (HP:0002859)3.11477787
18Medulloblastoma (HP:0002885)3.07226140
19Duodenal stenosis (HP:0100867)3.02821531
20Small intestinal stenosis (HP:0012848)3.02821531
21Nephroblastoma (Wilms tumor) (HP:0002667)2.80946384
22Abnormality of the duodenum (HP:0002246)2.77391040
23Abnormal lung lobation (HP:0002101)2.74334490
24Decreased muscle mass (HP:0003199)2.66195201
25Pancreatic islet-cell hyperplasia (HP:0004510)2.66172548
26Abnormality of the astrocytes (HP:0100707)2.65157021
27Astrocytoma (HP:0009592)2.65157021
28Glioma (HP:0009733)2.62511496
29Embryonal renal neoplasm (HP:0011794)2.62179609
30Shoulder girdle muscle weakness (HP:0003547)2.60882009
31Muscle fiber atrophy (HP:0100295)2.44378240
32Myelodysplasia (HP:0002863)2.39096335
33Spastic diplegia (HP:0001264)2.36426482
34Pelvic girdle muscle weakness (HP:0003749)2.30993589
35Septo-optic dysplasia (HP:0100842)2.30617395
36Absent radius (HP:0003974)2.30050847
37Cortical dysplasia (HP:0002539)2.28069474
38Abnormality of the carotid arteries (HP:0005344)2.25132266
39Upper limb muscle weakness (HP:0003484)2.22745775
40Neoplasm of the colon (HP:0100273)2.22470801
41Intestinal atresia (HP:0011100)2.19621057
42Triphalangeal thumb (HP:0001199)2.18943249
43Clubbing of toes (HP:0100760)2.18038884
44Aplasia involving forearm bones (HP:0009822)2.13317015
45Absent forearm bone (HP:0003953)2.13317015
46Aplasia/Hypoplasia of the sacrum (HP:0008517)2.11916659
47Neoplasm of striated muscle (HP:0009728)2.11899086
48Amniotic constriction ring (HP:0009775)2.11358097
49Abnormality of placental membranes (HP:0011409)2.11358097
50Absent septum pellucidum (HP:0001331)2.11036056
51Acute encephalopathy (HP:0006846)2.09362693
52Sloping forehead (HP:0000340)2.09123578
53Aqueductal stenosis (HP:0002410)2.08244543
54Abnormality of the musculature of the hand (HP:0001421)2.07473822
55Abnormality of the hip-girdle musculature (HP:0001445)2.07443559
56Abnormality of the musculature of the pelvis (HP:0001469)2.07443559
57Carpal bone hypoplasia (HP:0001498)2.06231052
58Small hand (HP:0200055)2.06038444
59Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.04855686
60Neoplasm of the oral cavity (HP:0100649)2.04141763
61Atonic seizures (HP:0010819)2.03035426
62Depressed nasal tip (HP:0000437)2.00912840
63Increased nuchal translucency (HP:0010880)1.95089718
64Aplasia/Hypoplasia of the sternum (HP:0006714)1.93723183
65Progressive external ophthalmoplegia (HP:0000590)1.93301802
66Abnormality of serum amino acid levels (HP:0003112)1.90797365
67Lower limb amyotrophy (HP:0007210)1.89701480
68Biliary tract neoplasm (HP:0100574)1.89683272
69Dyschromatopsia (HP:0007641)1.88251530
70Abnormality of the septum pellucidum (HP:0007375)1.87722539
71Breast aplasia (HP:0100783)1.84956962
72Hyperglycinuria (HP:0003108)1.83521197
73Symptomatic seizures (HP:0011145)1.83224813
74Limb hypertonia (HP:0002509)1.80217608
75Ovarian neoplasm (HP:0100615)1.79177716
76Abnormality of endocrine pancreas physiology (HP:0012093)1.78715002
77Abnormality of the pancreatic islet cells (HP:0006476)1.78715002
78Gonadotropin excess (HP:0000837)1.78537882
79Stenosis of the external auditory canal (HP:0000402)1.75827114
80Urethral obstruction (HP:0000796)1.73827424
81Multiple enchondromatosis (HP:0005701)1.72854710
82Decreased motor nerve conduction velocity (HP:0003431)1.72801302
83Hammertoe (HP:0001765)1.72526533
84Pendular nystagmus (HP:0012043)1.71833476
85Ectopic kidney (HP:0000086)1.70850009
86Aplasia/Hypoplasia of the breasts (HP:0010311)1.68007050
87Absent thumb (HP:0009777)1.67726307
88Bone marrow hypocellularity (HP:0005528)1.67725368
89Long nose (HP:0003189)1.67037182
90Facial hemangioma (HP:0000329)1.66929843
91Steppage gait (HP:0003376)1.64320056
92Hypoglycemic seizures (HP:0002173)1.64173990
93Small epiphyses (HP:0010585)1.64140171
94Bilateral microphthalmos (HP:0007633)1.62403500
95Supernumerary spleens (HP:0009799)1.61446246
96Abnormality of cochlea (HP:0000375)1.60482716
97Abnormality of glycine metabolism (HP:0010895)1.59978907
98Abnormality of serine family amino acid metabolism (HP:0010894)1.59978907
99Hyperalaninemia (HP:0003348)1.59324550
100Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.59324550

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.28521274
2BMPR1B3.91636442
3ACVR1B3.61890003
4CDC73.35435676
5MKNK23.14840274
6WEE12.74377445
7WNK32.60009366
8TSSK62.52495676
9BRSK22.46777655
10MKNK12.35188242
11TAF12.33775941
12TTK2.28500382
13ZAK2.27648068
14EIF2AK32.22385421
15PLK42.19860037
16PLK32.16458046
17PBK2.14513883
18SRPK12.10176437
19PNCK1.85487508
20VRK11.84673674
21TGFBR11.79861874
22CASK1.74839338
23MST41.73663050
24PLK11.70248623
25MAP3K101.67767302
26TNIK1.67434444
27FRK1.54229945
28TRIM281.46797594
29ERBB41.41882319
30EIF2AK21.41233101
31NUAK11.31458511
32BRD41.26844266
33ATR1.26247623
34NEK11.21471835
35SCYL21.12447651
36MAP4K21.11253914
37CCNB11.10146766
38AURKB1.09550781
39BRSK11.08876117
40CHEK21.05533520
41MELK0.97841329
42ATM0.97594788
43DYRK30.92366652
44OXSR10.89980494
45STK160.88917323
46AURKA0.88036424
47MARK10.86926968
48ALK0.80993759
49NEK20.79017606
50TLK10.76241543
51LATS20.76083425
52DYRK20.75098485
53STK390.71601855
54CHEK10.71390551
55CDK30.70054152
56VRK20.67634010
57EIF2AK10.66249401
58PASK0.62761070
59PRKCG0.62578207
60STK40.61647053
61SGK20.60403205
62PIM20.59760226
63CDK70.52587400
64CDK10.50522102
65PRKCH0.48018105
66PRKDC0.47310484
67MINK10.46553614
68YES10.45802729
69STK30.45093821
70CDK20.44983369
71CSNK2A20.44524567
72CSNK1E0.44254473
73FGFR20.41675538
74INSRR0.41281771
75STK110.39603632
76RPS6KB10.38762814
77PIM10.38732048
78ERBB30.38698703
79TESK20.38161839
80NME10.37069853
81DYRK1A0.36924534
82CSNK2A10.35185610
83CDK80.33082695
84FGFR10.31905358
85TIE10.31787799
86CSNK1G10.29530139
87PRKACB0.29334073
88RPS6KA50.28782050
89MAP2K10.28423579
90MAP3K40.26413803
91PRKCE0.26363542
92GSK3B0.24698096
93GSK3A0.23769440
94PIK3CA0.22562825
95CAMK2A0.22364203
96MAPK90.20911349
97CDK190.20266547
98NEK60.19347508
99SGK2230.19047627
100SGK4940.19047627

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.93524820
2DNA replication_Homo sapiens_hsa030303.88510254
3Non-homologous end-joining_Homo sapiens_hsa034503.67385297
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.64810433
5Proteasome_Homo sapiens_hsa030503.37901225
6Fanconi anemia pathway_Homo sapiens_hsa034603.01000794
7Cell cycle_Homo sapiens_hsa041102.79760883
8RNA polymerase_Homo sapiens_hsa030202.79106322
9RNA transport_Homo sapiens_hsa030132.50903462
10Homologous recombination_Homo sapiens_hsa034402.49924153
11Basal transcription factors_Homo sapiens_hsa030222.35834491
12Base excision repair_Homo sapiens_hsa034102.22979055
13Protein export_Homo sapiens_hsa030602.20299049
14RNA degradation_Homo sapiens_hsa030182.19884675
15Spliceosome_Homo sapiens_hsa030402.08963215
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.07273410
17Selenocompound metabolism_Homo sapiens_hsa004501.91528761
18Nucleotide excision repair_Homo sapiens_hsa034201.84619238
19mRNA surveillance pathway_Homo sapiens_hsa030151.84291854
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.83931674
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.83253333
22One carbon pool by folate_Homo sapiens_hsa006701.77931279
23Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.72295068
24Pyrimidine metabolism_Homo sapiens_hsa002401.56693684
25Propanoate metabolism_Homo sapiens_hsa006401.54551785
26Pyruvate metabolism_Homo sapiens_hsa006201.47932595
27Vitamin B6 metabolism_Homo sapiens_hsa007501.45905659
28Systemic lupus erythematosus_Homo sapiens_hsa053221.41606846
29Oocyte meiosis_Homo sapiens_hsa041141.36796650
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35786076
31p53 signaling pathway_Homo sapiens_hsa041151.31421946
32Fatty acid elongation_Homo sapiens_hsa000621.18443501
33Purine metabolism_Homo sapiens_hsa002301.16036561
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16030282
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.05492604
36Ribosome_Homo sapiens_hsa030101.04444805
37Taste transduction_Homo sapiens_hsa047421.03812002
38TGF-beta signaling pathway_Homo sapiens_hsa043501.03607065
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02889436
40Steroid biosynthesis_Homo sapiens_hsa001001.00469643
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.98213997
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94754711
43Parkinsons disease_Homo sapiens_hsa050120.92795015
44Alcoholism_Homo sapiens_hsa050340.86763384
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86748309
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85328261
47Huntingtons disease_Homo sapiens_hsa050160.84575540
48Circadian rhythm_Homo sapiens_hsa047100.79455530
49Oxidative phosphorylation_Homo sapiens_hsa001900.72244021
50Epstein-Barr virus infection_Homo sapiens_hsa051690.67715864
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67062483
52Hippo signaling pathway_Homo sapiens_hsa043900.65275533
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59904844
54Viral carcinogenesis_Homo sapiens_hsa052030.59199341
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58090832
56Phototransduction_Homo sapiens_hsa047440.55666730
57Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54936074
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53457984
59Fatty acid metabolism_Homo sapiens_hsa012120.51744226
60Colorectal cancer_Homo sapiens_hsa052100.50661419
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50411542
62Caffeine metabolism_Homo sapiens_hsa002320.49633225
63MicroRNAs in cancer_Homo sapiens_hsa052060.47269260
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44348384
65Biosynthesis of amino acids_Homo sapiens_hsa012300.43926406
66Wnt signaling pathway_Homo sapiens_hsa043100.42592220
67Lysine degradation_Homo sapiens_hsa003100.41167862
68Nicotine addiction_Homo sapiens_hsa050330.40066728
69Fatty acid degradation_Homo sapiens_hsa000710.38603167
70beta-Alanine metabolism_Homo sapiens_hsa004100.38598735
71Alzheimers disease_Homo sapiens_hsa050100.38241493
72Carbon metabolism_Homo sapiens_hsa012000.37630413
73Glutamatergic synapse_Homo sapiens_hsa047240.36325498
74Glutathione metabolism_Homo sapiens_hsa004800.35946950
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35084071
76Butanoate metabolism_Homo sapiens_hsa006500.34953194
77Vitamin digestion and absorption_Homo sapiens_hsa049770.31770802
78Basal cell carcinoma_Homo sapiens_hsa052170.31565004
79Ovarian steroidogenesis_Homo sapiens_hsa049130.31028810
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30386311
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30024627
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29759121
83Metabolic pathways_Homo sapiens_hsa011000.28995203
84HTLV-I infection_Homo sapiens_hsa051660.28262967
85Hedgehog signaling pathway_Homo sapiens_hsa043400.27264915
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.25208008
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.25089282
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.23444232
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.22371604
90Retinol metabolism_Homo sapiens_hsa008300.20534897
91Intestinal immune network for IgA production_Homo sapiens_hsa046720.20488764
92Fatty acid biosynthesis_Homo sapiens_hsa000610.20334534
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.17914279
94Tryptophan metabolism_Homo sapiens_hsa003800.17887466
95Olfactory transduction_Homo sapiens_hsa047400.17665528
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.16781513
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.14643368
98Tight junction_Homo sapiens_hsa045300.14109592
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.13874307
100Herpes simplex infection_Homo sapiens_hsa051680.13837732

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