ZNF879

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)9.62652605
2nucleobase catabolic process (GO:0046113)7.44097032
3response to pheromone (GO:0019236)6.03215958
4protein localization to cilium (GO:0061512)4.84150195
5regulation of cilium movement (GO:0003352)4.55254540
6intraciliary transport (GO:0042073)4.09718597
7neural tube formation (GO:0001841)4.02138631
8presynaptic membrane assembly (GO:0097105)3.99303058
9neuron cell-cell adhesion (GO:0007158)3.92987878
10postsynaptic membrane organization (GO:0001941)3.88751996
11C4-dicarboxylate transport (GO:0015740)3.72702584
12positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.70840583
13regulation of feeding behavior (GO:0060259)3.65715808
14piRNA metabolic process (GO:0034587)3.65164491
15acrosome assembly (GO:0001675)3.52456449
16DNA damage response, detection of DNA damage (GO:0042769)3.50362262
17presynaptic membrane organization (GO:0097090)3.49619023
18negative regulation of mast cell activation (GO:0033004)3.48265893
19snRNA processing (GO:0016180)3.46861764
20epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.46650990
21centriole replication (GO:0007099)3.46215899
22mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.42583717
23mitochondrial respiratory chain complex I assembly (GO:0032981)3.42583717
24NADH dehydrogenase complex assembly (GO:0010257)3.42583717
25regulation of DNA endoreduplication (GO:0032875)3.40653719
26regulation of glucokinase activity (GO:0033131)3.38744428
27regulation of hexokinase activity (GO:1903299)3.38744428
28gamma-aminobutyric acid transport (GO:0015812)3.29419862
29atrial cardiac muscle cell action potential (GO:0086014)3.27749672
30protein deneddylation (GO:0000338)3.19966953
31inositol phosphate catabolic process (GO:0071545)3.18016746
32L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.17043894
33DNA integration (GO:0015074)3.06128910
34vocalization behavior (GO:0071625)3.05389774
35cullin deneddylation (GO:0010388)3.04680151
36sympathetic nervous system development (GO:0048485)3.04286938
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.03931813
38behavioral response to ethanol (GO:0048149)3.03609050
39brain morphogenesis (GO:0048854)3.03149653
40central nervous system projection neuron axonogenesis (GO:0021952)3.01951997
41pyrimidine-containing compound catabolic process (GO:0072529)3.00453004
42pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.97922772
43UMP biosynthetic process (GO:0006222)2.97922772
44pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.97922772
45UMP metabolic process (GO:0046049)2.97922772
46snRNA metabolic process (GO:0016073)2.91537402
47protein complex biogenesis (GO:0070271)2.90910743
48inositol phosphate dephosphorylation (GO:0046855)2.90004719
49phosphorylated carbohydrate dephosphorylation (GO:0046838)2.90004719
50negative regulation of DNA-dependent DNA replication (GO:2000104)2.89495920
51magnesium ion transport (GO:0015693)2.89015846
52head development (GO:0060322)2.88086504
53regulation of microtubule-based movement (GO:0060632)2.87583962
54DNA methylation involved in gamete generation (GO:0043046)2.83233018
55synapse assembly (GO:0007416)2.82965427
56limb bud formation (GO:0060174)2.81411272
57positive regulation of mitochondrial fission (GO:0090141)2.81054885
58cilium morphogenesis (GO:0060271)2.78256742
59olfactory bulb development (GO:0021772)2.74447014
60glycosphingolipid biosynthetic process (GO:0006688)2.72488035
61positive regulation of megakaryocyte differentiation (GO:0045654)2.69012253
62epithelial cilium movement (GO:0003351)2.68151292
63photoreceptor cell maintenance (GO:0045494)2.67655618
64protein polyglutamylation (GO:0018095)2.67184069
65protein neddylation (GO:0045116)2.65704635
66calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.65651464
67retinal ganglion cell axon guidance (GO:0031290)2.64284938
68water-soluble vitamin biosynthetic process (GO:0042364)2.62958393
69indolalkylamine metabolic process (GO:0006586)2.62351056
70G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.62112535
71regulation of male gonad development (GO:2000018)2.60931878
72central nervous system neuron axonogenesis (GO:0021955)2.59781502
73neurotransmitter-gated ion channel clustering (GO:0072578)2.59098342
74negative regulation of transcription regulatory region DNA binding (GO:2000678)2.57118311
75regulation of development, heterochronic (GO:0040034)2.56511120
76fatty acid elongation (GO:0030497)2.56468126
77RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.56101386
78regulation of timing of cell differentiation (GO:0048505)2.55220344
79L-methionine salvage (GO:0071267)2.53687177
80L-methionine biosynthetic process (GO:0071265)2.53687177
81amino acid salvage (GO:0043102)2.53687177
82mitochondrial respiratory chain complex assembly (GO:0033108)2.53605445
83positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.49927595
84behavioral response to nicotine (GO:0035095)2.48775285
85histone H2A acetylation (GO:0043968)2.48181201
86glutamate receptor signaling pathway (GO:0007215)2.47590616
87positive regulation of potassium ion transmembrane transport (GO:1901381)2.46675481
88detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.46232218
89mitochondrion morphogenesis (GO:0070584)2.44935871
90pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.44848463
91histone mRNA metabolic process (GO:0008334)2.43560153
92neuron fate determination (GO:0048664)2.43447970
93membrane invagination (GO:0010324)2.43047629
94negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.42527401
95cilium organization (GO:0044782)2.41170905
96mitochondrial fission (GO:0000266)2.41158417
97nucleotide transmembrane transport (GO:1901679)2.39499288
98ganglion development (GO:0061548)2.39400280
99retinal cone cell development (GO:0046549)2.39239831
100GPI anchor metabolic process (GO:0006505)2.39236579

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ZNF274_21170338_ChIP-Seq_K562_Hela4.07819760
2IGF1R_20145208_ChIP-Seq_DFB_Human3.82884447
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.56666524
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.37353132
5GBX2_23144817_ChIP-Seq_PC3_Human3.35148625
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.00993577
7TAF15_26573619_Chip-Seq_HEK293_Human2.84521398
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.82039837
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.80955506
10VDR_22108803_ChIP-Seq_LS180_Human2.76686320
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.69625819
12FUS_26573619_Chip-Seq_HEK293_Human2.62669787
13EZH2_22144423_ChIP-Seq_EOC_Human2.54729235
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.40144905
15EWS_26573619_Chip-Seq_HEK293_Human2.36473316
16* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.27745803
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.23824414
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.19417458
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.17203455
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.11046228
21P300_19829295_ChIP-Seq_ESCs_Human2.10344923
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.06370997
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.04478502
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.90878412
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.90377507
26UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.78122716
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.77332039
28SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.71611229
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.69484505
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.63969966
31IRF1_19129219_ChIP-ChIP_H3396_Human1.62031407
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58261076
33SMAD4_21799915_ChIP-Seq_A2780_Human1.58157356
34MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56103390
35ER_23166858_ChIP-Seq_MCF-7_Human1.55190790
36OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53753659
37RNF2_27304074_Chip-Seq_NSC_Mouse1.50937756
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49117408
39TP53_22573176_ChIP-Seq_HFKS_Human1.47454249
40VDR_23849224_ChIP-Seq_CD4+_Human1.46681806
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46556558
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45772360
43STAT3_23295773_ChIP-Seq_U87_Human1.43096912
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.42208570
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42200516
46CBP_20019798_ChIP-Seq_JUKART_Human1.42200516
47ELK1_19687146_ChIP-ChIP_HELA_Human1.41459133
48AR_25329375_ChIP-Seq_VCAP_Human1.38508014
49BCAT_22108803_ChIP-Seq_LS180_Human1.34911298
50TCF4_23295773_ChIP-Seq_U87_Human1.30761745
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30206693
52KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29637187
53TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28578493
54RUNX2_22187159_ChIP-Seq_PCA_Human1.25792378
55CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22272118
56ETS1_20019798_ChIP-Seq_JURKAT_Human1.21481322
57NANOG_18555785_Chip-Seq_ESCs_Mouse1.21287776
58REST_21632747_ChIP-Seq_MESCs_Mouse1.21279505
59SOX2_19829295_ChIP-Seq_ESCs_Human1.19533565
60NANOG_19829295_ChIP-Seq_ESCs_Human1.19533565
61MYC_18940864_ChIP-ChIP_HL60_Human1.19091897
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18532990
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.18132038
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17583992
65EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17292442
66NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16055796
67NOTCH1_21737748_ChIP-Seq_TLL_Human1.14901002
68TCF4_22108803_ChIP-Seq_LS180_Human1.12815192
69FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12108239
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11703346
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10104640
72TAL1_26923725_Chip-Seq_HPCs_Mouse1.06501493
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05100697
74P53_22387025_ChIP-Seq_ESCs_Mouse1.03849927
75SRF_21415370_ChIP-Seq_HL-1_Mouse1.03601146
76NCOR_22424771_ChIP-Seq_293T_Human1.02306639
77BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01851963
78CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01427325
79ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01293379
80BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.99879342
81FLI1_21867929_ChIP-Seq_TH2_Mouse0.99599007
82PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99289868
83NFE2_27457419_Chip-Seq_LIVER_Mouse0.99045750
84EZH2_27294783_Chip-Seq_NPCs_Mouse0.98996489
85KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98548988
86NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98471225
87KDM2B_26808549_Chip-Seq_REH_Human0.98184184
88SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97884270
89FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97024165
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96469686
91RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95317479
92PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95099137
93CMYC_18555785_Chip-Seq_ESCs_Mouse0.94859607
94E2F1_18555785_Chip-Seq_ESCs_Mouse0.94624491
95SOX2_21211035_ChIP-Seq_LN229_Gbm0.94167313
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93945567
97REST_18959480_ChIP-ChIP_MESCs_Mouse0.93778064
98SMAD4_21741376_ChIP-Seq_EPCs_Human0.93537635
99PRDM14_20953172_ChIP-Seq_ESCs_Human0.93302192
100FOXP3_21729870_ChIP-Seq_TREG_Human0.92311801

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.57456719
2MP0003880_abnormal_central_pattern3.43243250
3MP0002102_abnormal_ear_morphology3.39054468
4MP0002837_dystrophic_cardiac_calcinosis3.32806526
5MP0001529_abnormal_vocalization3.02409052
6MP0008877_abnormal_DNA_methylation3.00199142
7MP0002736_abnormal_nociception_after2.53293703
8MP0000516_abnormal_urinary_system2.46867798
9MP0005367_renal/urinary_system_phenotyp2.46867798
10MP0001968_abnormal_touch/_nociception2.43425410
11MP0001984_abnormal_olfaction2.34288884
12MP0001986_abnormal_taste_sensitivity2.22144093
13MP0001486_abnormal_startle_reflex2.15460250
14MP0003787_abnormal_imprinting2.15430968
15MP0008789_abnormal_olfactory_epithelium2.09096637
16MP0004133_heterotaxia2.05528657
17MP0000778_abnormal_nervous_system1.88405553
18MP0002751_abnormal_autonomic_nervous1.88351922
19MP0005394_taste/olfaction_phenotype1.80794128
20MP0005499_abnormal_olfactory_system1.80794128
21MP0005187_abnormal_penis_morphology1.79947538
22MP0004859_abnormal_synaptic_plasticity1.78596066
23MP0004142_abnormal_muscle_tone1.77037639
24MP0009745_abnormal_behavioral_response1.70303026
25MP0008058_abnormal_DNA_repair1.68510272
26MP0000372_irregular_coat_pigmentation1.62649774
27MP0004885_abnormal_endolymph1.62192247
28MP0009046_muscle_twitch1.57866141
29MP0005386_behavior/neurological_phenoty1.57763761
30MP0004924_abnormal_behavior1.57763761
31MP0005174_abnormal_tail_pigmentation1.56501261
32MP0008872_abnormal_physiological_respon1.51111967
33MP0005075_abnormal_melanosome_morpholog1.48534375
34MP0002272_abnormal_nervous_system1.47784468
35MP0003635_abnormal_synaptic_transmissio1.46958437
36MP0000631_abnormal_neuroendocrine_gland1.45364891
37MP0005646_abnormal_pituitary_gland1.44464013
38MP0003646_muscle_fatigue1.41860340
39MP0006276_abnormal_autonomic_nervous1.41277963
40MP0003119_abnormal_digestive_system1.35719431
41MP0005551_abnormal_eye_electrophysiolog1.35379086
42MP0005084_abnormal_gallbladder_morpholo1.34983810
43MP0002067_abnormal_sensory_capabilities1.33577943
44MP0003121_genomic_imprinting1.33416509
45MP0006292_abnormal_olfactory_placode1.31707568
46MP0002735_abnormal_chemical_nociception1.24909233
47MP0002064_seizures1.20355034
48MP0002254_reproductive_system_inflammat1.19756599
49MP0001177_atelectasis1.19695333
50MP0004215_abnormal_myocardial_fiber1.17288203
51MP0001485_abnormal_pinna_reflex1.16525806
52MP0000955_abnormal_spinal_cord1.16147218
53MP0003136_yellow_coat_color1.12348137
54MP0002234_abnormal_pharynx_morphology1.11675188
55MP0000015_abnormal_ear_pigmentation1.11259233
56MP0002184_abnormal_innervation1.10667285
57MP0002063_abnormal_learning/memory/cond1.09176766
58MP0000647_abnormal_sebaceous_gland1.05426546
59MP0002233_abnormal_nose_morphology1.03807656
60MP0000749_muscle_degeneration1.01279055
61MP0005253_abnormal_eye_physiology1.00771162
62MP0003137_abnormal_impulse_conducting0.99657679
63MP0001764_abnormal_homeostasis0.99583598
64MP0002734_abnormal_mechanical_nocicepti0.99451697
65MP0002572_abnormal_emotion/affect_behav0.98941971
66MP0006035_abnormal_mitochondrial_morpho0.98627006
67MP0001970_abnormal_pain_threshold0.98024185
68MP0003937_abnormal_limbs/digits/tail_de0.97566346
69MP0002938_white_spotting0.96819734
70MP0003718_maternal_effect0.96494242
71MP0004811_abnormal_neuron_physiology0.96255114
72MP0002752_abnormal_somatic_nervous0.95560609
73MP0003698_abnormal_male_reproductive0.95105662
74MP0002733_abnormal_thermal_nociception0.94304039
75MP0005423_abnormal_somatic_nervous0.93125005
76MP0003890_abnormal_embryonic-extraembry0.90540940
77MP0002882_abnormal_neuron_morphology0.89768026
78MP0003195_calcinosis0.89538779
79MP0003122_maternal_imprinting0.87712583
80MP0002638_abnormal_pupillary_reflex0.87118701
81MP0000026_abnormal_inner_ear0.86805607
82MP0003943_abnormal_hepatobiliary_system0.86323716
83MP0002095_abnormal_skin_pigmentation0.86048996
84MP0000049_abnormal_middle_ear0.85271208
85MP0001324_abnormal_eye_pigmentation0.82137964
86MP0002163_abnormal_gland_morphology0.80871684
87MP0003755_abnormal_palate_morphology0.80783887
88MP0008995_early_reproductive_senescence0.79750295
89MP0000427_abnormal_hair_cycle0.79666722
90MP0002822_catalepsy0.79517407
91MP0002152_abnormal_brain_morphology0.79282219
92MP0004130_abnormal_muscle_cell0.79244457
93MP0002876_abnormal_thyroid_physiology0.79194775
94MP0005195_abnormal_posterior_eye0.78109552
95MP0001963_abnormal_hearing_physiology0.77986868
96MP0001929_abnormal_gametogenesis0.76991553
97MP0008057_abnormal_DNA_replication0.74097382
98MP0006072_abnormal_retinal_apoptosis0.74051599
99MP0004270_analgesia0.71798080
100MP0002229_neurodegeneration0.70229857

Predicted human phenotypes

RankGene SetZ-score
1Progressive inability to walk (HP:0002505)4.19711069
2Focal motor seizures (HP:0011153)4.16090015
3Aplasia/Hypoplasia of the tibia (HP:0005772)3.80217919
4Short tibia (HP:0005736)3.65871517
5Pancreatic cysts (HP:0001737)3.46136342
6True hermaphroditism (HP:0010459)3.38666452
7Nephronophthisis (HP:0000090)3.34590349
8Gaze-evoked nystagmus (HP:0000640)3.31372718
9Focal seizures (HP:0007359)3.27249112
10Pancreatic fibrosis (HP:0100732)3.13988663
11Medial flaring of the eyebrow (HP:0010747)3.10925821
12Inability to walk (HP:0002540)3.08693693
13Amyotrophic lateral sclerosis (HP:0007354)2.85115429
14Drooling (HP:0002307)2.85067820
15Lissencephaly (HP:0001339)2.83795811
16Gait imbalance (HP:0002141)2.77558076
17Abnormality of the renal medulla (HP:0100957)2.72783344
18Methylmalonic acidemia (HP:0002912)2.67845980
19Congenital primary aphakia (HP:0007707)2.67717655
20Nephrogenic diabetes insipidus (HP:0009806)2.64483759
21Excessive salivation (HP:0003781)2.62909963
22Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.59993386
23Short 1st metacarpal (HP:0010034)2.59993386
24Genetic anticipation (HP:0003743)2.53040208
25Abnormality of the labia minora (HP:0012880)2.49755183
26Genital tract atresia (HP:0001827)2.48641147
27Chronic hepatic failure (HP:0100626)2.47717040
28Tetraplegia (HP:0002445)2.38625787
29Supernumerary spleens (HP:0009799)2.38274430
30Aplasia/Hypoplasia of the tongue (HP:0010295)2.36011484
31Atrophy/Degeneration involving motor neurons (HP:0007373)2.35295680
32Hyperglycinemia (HP:0002154)2.30874226
33Tubulointerstitial nephritis (HP:0001970)2.28457598
34Molar tooth sign on MRI (HP:0002419)2.26200831
35Abnormality of midbrain morphology (HP:0002418)2.26200831
36Abnormality of the 1st metacarpal (HP:0010009)2.26190464
37Abnormality of the musculature of the pelvis (HP:0001469)2.19938180
38Abnormality of the hip-girdle musculature (HP:0001445)2.19938180
39Febrile seizures (HP:0002373)2.19669516
40Vaginal atresia (HP:0000148)2.19265527
41Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.19136279
42Polyphagia (HP:0002591)2.18338403
43Broad-based gait (HP:0002136)2.17050284
44Postaxial hand polydactyly (HP:0001162)2.16483534
45Pachygyria (HP:0001302)2.14504625
46Postaxial foot polydactyly (HP:0001830)2.13330786
47Hemiparesis (HP:0001269)2.12921210
48Progressive cerebellar ataxia (HP:0002073)2.12845294
49Methylmalonic aciduria (HP:0012120)2.12064717
50Abnormality of the anterior horn cell (HP:0006802)2.09975703
51Degeneration of anterior horn cells (HP:0002398)2.09975703
52Absent speech (HP:0001344)2.09964603
53Peripheral hypomyelination (HP:0007182)2.09925971
54Ulnar claw (HP:0001178)2.08261046
55Abnormality of the renal cortex (HP:0011035)2.04921515
56Cortical dysplasia (HP:0002539)2.01192569
57Acute necrotizing encephalopathy (HP:0006965)1.99260552
58Hyperventilation (HP:0002883)1.95004841
59Cystic liver disease (HP:0006706)1.94664418
60Congenital hepatic fibrosis (HP:0002612)1.93161751
61Poor coordination (HP:0002370)1.92924921
62Dyskinesia (HP:0100660)1.92745296
63Abolished electroretinogram (ERG) (HP:0000550)1.92727410
64Dysdiadochokinesis (HP:0002075)1.87714789
65Abnormal drinking behavior (HP:0030082)1.86969049
66Polydipsia (HP:0001959)1.86969049
67Generalized tonic-clonic seizures (HP:0002069)1.86764892
68Volvulus (HP:0002580)1.86290968
69Dialeptic seizures (HP:0011146)1.84531580
70Tubulointerstitial abnormality (HP:0001969)1.84428346
71Congenital stationary night blindness (HP:0007642)1.84402031
72Abnormal hair whorl (HP:0010721)1.83962850
73Optic disc pallor (HP:0000543)1.83309416
74Progressive macrocephaly (HP:0004481)1.82631653
75Abnormality of pyrimidine metabolism (HP:0004353)1.81348022
76Neonatal respiratory distress (HP:0002643)1.81196022
77Bile duct proliferation (HP:0001408)1.79840345
78Abnormal biliary tract physiology (HP:0012439)1.79840345
79CNS hypomyelination (HP:0003429)1.78809363
80Shoulder girdle muscle weakness (HP:0003547)1.78593788
81Increased CSF lactate (HP:0002490)1.77255859
82Agnosia (HP:0010524)1.76665557
83Attenuation of retinal blood vessels (HP:0007843)1.75356697
84Poor suck (HP:0002033)1.73544027
85Septo-optic dysplasia (HP:0100842)1.73470958
86Aplasia/Hypoplasia of the spleen (HP:0010451)1.72540574
87Failure to thrive in infancy (HP:0001531)1.72097964
88Optic nerve hypoplasia (HP:0000609)1.71948133
89Acute encephalopathy (HP:0006846)1.71877402
90Occipital encephalocele (HP:0002085)1.71070149
91Urinary urgency (HP:0000012)1.70850191
92Abnormal lung lobation (HP:0002101)1.69845670
93Fair hair (HP:0002286)1.69693268
94Generalized myoclonic seizures (HP:0002123)1.69609297
95Abnormality of the vitamin B12 metabolism (HP:0004341)1.68658117
96Anencephaly (HP:0002323)1.68537569
97Muscular hypotonia of the trunk (HP:0008936)1.67642552
98Tubular atrophy (HP:0000092)1.65768282
99Abnormality of vitamin B metabolism (HP:0004340)1.65621397
100Retinal dysplasia (HP:0007973)1.64086403

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.46028491
2FRK2.98471437
3WNK32.95531604
4MAP4K22.87178189
5CAMKK22.76888394
6CASK2.70447183
7TRIM282.58870509
8EPHA32.34379380
9MAP3K42.31835064
10BCR2.23579280
11EPHA42.11898034
12ERBB32.05997050
13MAPK132.03360541
14MAP2K71.97341665
15BMPR1B1.90756564
16PLK21.90115808
17CCNB11.80447777
18PRKD31.78688743
19PAK31.72150403
20DYRK21.62789655
21STK391.53208033
22CSNK1G21.51930515
23DYRK31.50437886
24WNK41.50312647
25SRPK11.49520958
26CSNK1G31.40103665
27ACVR1B1.34613701
28NUAK11.33389713
29RPS6KA41.28242071
30DAPK21.23204629
31PDK21.18850052
32CSNK1G11.17899299
33ADRBK21.17190310
34CSNK1A1L1.16414592
35PINK11.15109927
36PRKCE1.11404469
37MKNK21.10657922
38TNIK1.06544221
39DYRK1A1.05431102
40BRSK21.02442188
41CAMK41.00217316
42MINK10.99875819
43ZAK0.97736446
44GRK10.97705207
45FER0.95754383
46BCKDK0.93601498
47CLK10.93518900
48VRK10.90381130
49NTRK30.81355945
50OBSCN0.79266651
51TYRO30.77694179
52CAMK2B0.77330598
53MATK0.76018652
54YES10.74298030
55PLK30.73221548
56MKNK10.72307640
57IRAK10.71565693
58RPS6KA50.68619140
59PLK40.65937965
60CDK50.64890782
61PHKG20.64873973
62PHKG10.64873973
63CAMK2A0.64849617
64STK38L0.64684687
65MAP2K40.64641298
66FGR0.64553872
67PRKCG0.61010729
68PKN10.60088224
69INSRR0.58567568
70ADRBK10.54783333
71CAMK10.54634792
72PLK10.54010837
73TXK0.52861627
74PRKACA0.52838973
75TIE10.51286059
76PRKCZ0.51171831
77CSNK1D0.48504196
78PBK0.48277105
79MAP3K70.47025574
80PRKCQ0.46244781
81CSNK1A10.46192853
82DAPK10.45762552
83OXSR10.45159124
84CAMK2D0.44798354
85EIF2AK30.44097394
86GRK70.43984431
87STK380.42786658
88CDK190.41970948
89NTRK20.41100451
90PRKG10.40558952
91STK160.39773408
92NEK10.38962958
93DYRK1B0.38590573
94STK110.37982271
95CAMKK10.36534255
96NEK60.34161166
97UHMK10.33692637
98ATM0.32677192
99CDK30.32531719
100RPS6KA30.31093561

Predicted pathways (KEGG)

RankGene SetZ-score
1Pantothenate and CoA biosynthesis_Homo sapiens_hsa007703.20862774
2Nicotine addiction_Homo sapiens_hsa050332.94259027
3Basal transcription factors_Homo sapiens_hsa030222.92130840
4Protein export_Homo sapiens_hsa030602.58600188
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.55948148
6Selenocompound metabolism_Homo sapiens_hsa004502.17089477
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05246125
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.99471205
9Phototransduction_Homo sapiens_hsa047441.99447433
10beta-Alanine metabolism_Homo sapiens_hsa004101.95371138
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.90629790
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.89831039
13Oxidative phosphorylation_Homo sapiens_hsa001901.88549012
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.86130362
15Butanoate metabolism_Homo sapiens_hsa006501.81424626
16Non-homologous end-joining_Homo sapiens_hsa034501.79438103
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.78141734
18Ether lipid metabolism_Homo sapiens_hsa005651.73991550
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.71066248
20GABAergic synapse_Homo sapiens_hsa047271.67608219
21Collecting duct acid secretion_Homo sapiens_hsa049661.66487042
22Linoleic acid metabolism_Homo sapiens_hsa005911.62276588
23RNA polymerase_Homo sapiens_hsa030201.58546654
24Parkinsons disease_Homo sapiens_hsa050121.52332226
25Propanoate metabolism_Homo sapiens_hsa006401.52289934
26Regulation of autophagy_Homo sapiens_hsa041401.50032111
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.47811308
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44031667
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43121587
30RNA degradation_Homo sapiens_hsa030181.41628678
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39152129
32Peroxisome_Homo sapiens_hsa041461.38313814
33Dorso-ventral axis formation_Homo sapiens_hsa043201.35746425
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.35532896
35Morphine addiction_Homo sapiens_hsa050321.35035171
36Fanconi anemia pathway_Homo sapiens_hsa034601.32810919
37Huntingtons disease_Homo sapiens_hsa050161.31691460
38Glutamatergic synapse_Homo sapiens_hsa047241.30991435
39Circadian rhythm_Homo sapiens_hsa047101.28727589
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.27486916
41Steroid biosynthesis_Homo sapiens_hsa001001.26616022
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26318329
43Circadian entrainment_Homo sapiens_hsa047131.25125029
44Base excision repair_Homo sapiens_hsa034101.24164320
45Fatty acid elongation_Homo sapiens_hsa000621.13862426
46Synaptic vesicle cycle_Homo sapiens_hsa047211.12774788
47RNA transport_Homo sapiens_hsa030131.12033077
48Olfactory transduction_Homo sapiens_hsa047401.09609462
49Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.05876774
50Taste transduction_Homo sapiens_hsa047421.05289548
51Dopaminergic synapse_Homo sapiens_hsa047281.01601332
52Serotonergic synapse_Homo sapiens_hsa047261.00944561
53Spliceosome_Homo sapiens_hsa030401.00572726
54Pyrimidine metabolism_Homo sapiens_hsa002400.98814701
55Tryptophan metabolism_Homo sapiens_hsa003800.97895082
56Alzheimers disease_Homo sapiens_hsa050100.94526595
57Nitrogen metabolism_Homo sapiens_hsa009100.87023481
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85464833
59Homologous recombination_Homo sapiens_hsa034400.82789182
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82604905
61Caffeine metabolism_Homo sapiens_hsa002320.80542140
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78107405
63Amphetamine addiction_Homo sapiens_hsa050310.76094479
64Cocaine addiction_Homo sapiens_hsa050300.71972381
65Axon guidance_Homo sapiens_hsa043600.70678319
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68854680
67Fatty acid metabolism_Homo sapiens_hsa012120.67519225
68Purine metabolism_Homo sapiens_hsa002300.66621156
69Folate biosynthesis_Homo sapiens_hsa007900.65528180
70Sphingolipid metabolism_Homo sapiens_hsa006000.64354977
71Mismatch repair_Homo sapiens_hsa034300.63944373
72Renin secretion_Homo sapiens_hsa049240.63488676
73Insulin secretion_Homo sapiens_hsa049110.63387878
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.61509530
75Ovarian steroidogenesis_Homo sapiens_hsa049130.61050582
76Metabolic pathways_Homo sapiens_hsa011000.60213640
77Cholinergic synapse_Homo sapiens_hsa047250.59920256
78Pyruvate metabolism_Homo sapiens_hsa006200.59239178
79Calcium signaling pathway_Homo sapiens_hsa040200.56993304
80Salivary secretion_Homo sapiens_hsa049700.56912332
81Nucleotide excision repair_Homo sapiens_hsa034200.53495977
82Oocyte meiosis_Homo sapiens_hsa041140.51265350
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.51030199
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.47745306
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39642285
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39583430
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37983272
88Glycerolipid metabolism_Homo sapiens_hsa005610.37860629
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37303033
90Cardiac muscle contraction_Homo sapiens_hsa042600.37220889
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36766850
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36146137
93Retinol metabolism_Homo sapiens_hsa008300.35623559
94Gastric acid secretion_Homo sapiens_hsa049710.34266574
95Long-term depression_Homo sapiens_hsa047300.33745300
96Chemical carcinogenesis_Homo sapiens_hsa052040.30971795
97Proteasome_Homo sapiens_hsa030500.30486123
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27103159
99Shigellosis_Homo sapiens_hsa051310.26497202
100mRNA surveillance pathway_Homo sapiens_hsa030150.26439478

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