ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	presynaptic membrane assembly (GO:0097105)	4.80517316
2	DNA double-strand break processing (GO:0000729)	4.39938591
3	presynaptic membrane organization (GO:0097090)	4.34942886
4	neuron cell-cell adhesion (GO:0007158)	3.82386672
5	pyrimidine nucleobase catabolic process (GO:0006208)	3.65079842
6	nonmotile primary cilium assembly (GO:0035058)	3.56988310
7	postsynaptic membrane organization (GO:0001941)	3.42324980
8	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.26199030
9	regulation of translation, ncRNA-mediated (GO:0045974)	3.26199030
10	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.26199030
11	vocalization behavior (GO:0071625)	3.17162943
12	L-serine metabolic process (GO:0006563)	3.12308797
13	water-soluble vitamin biosynthetic process (GO:0042364)	3.10272533
14	DNA damage response, detection of DNA damage (GO:0042769)	3.07158464
15	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.05616849
16	neurotransmitter-gated ion channel clustering (GO:0072578)	3.01622855
17	protein neddylation (GO:0045116)	3.00613464
18	cerebral cortex radially oriented cell migration (GO:0021799)	2.93375059
19	nucleobase catabolic process (GO:0046113)	2.91324227
20	chromatin remodeling at centromere (GO:0031055)	2.91042757
21	cullin deneddylation (GO:0010388)	2.87687028
22	histone H2A acetylation (GO:0043968)	2.87626079
23	C4-dicarboxylate transport (GO:0015740)	2.86823685
24	regulation of mitotic spindle checkpoint (GO:1903504)	2.77670513
25	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.77670513
26	regulation of meiosis I (GO:0060631)	2.74998838
27	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.74905927
28	CENP-A containing nucleosome assembly (GO:0034080)	2.74443810
29	limb bud formation (GO:0060174)	2.74011215
30	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.73463508
31	negative regulation of DNA recombination (GO:0045910)	2.72603223
32	olfactory bulb development (GO:0021772)	2.72361645
33	cholesterol biosynthetic process (GO:0006695)	2.69091868
34	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.65326348
35	somite development (GO:0061053)	2.64653623
36	regulation of collateral sprouting (GO:0048670)	2.64405596
37	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.62764230
38	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.62764230
39	replication fork processing (GO:0031297)	2.59331623
40	histone exchange (GO:0043486)	2.58559895
41	DNA replication-dependent nucleosome organization (GO:0034723)	2.55966538
42	DNA replication-dependent nucleosome assembly (GO:0006335)	2.55966538
43	retinal ganglion cell axon guidance (GO:0031290)	2.55821763
44	intraciliary transport (GO:0042073)	2.55504801
45	sterol biosynthetic process (GO:0016126)	2.54469297
46	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.53666642
47	respiratory chain complex IV assembly (GO:0008535)	2.51406485
48	protein localization to synapse (GO:0035418)	2.50769635
49	protein deneddylation (GO:0000338)	2.49078726
50	gamma-aminobutyric acid transport (GO:0015812)	2.48883429
51	regulation of development, heterochronic (GO:0040034)	2.48822459
52	response to nitrosative stress (GO:0051409)	2.47239759
53	peptidyl-cysteine modification (GO:0018198)	2.46897323
54	regulation of helicase activity (GO:0051095)	2.46307342
55	behavioral response to nicotine (GO:0035095)	2.44468528
56	DNA catabolic process, exonucleolytic (GO:0000738)	2.37761407
57	DNA replication-independent nucleosome organization (GO:0034724)	2.37641044
58	DNA replication-independent nucleosome assembly (GO:0006336)	2.37641044
59	righting reflex (GO:0060013)	2.37364627
60	synapse assembly (GO:0007416)	2.37100877
61	regulation of telomere maintenance (GO:0032204)	2.36748242
62	regulation of timing of cell differentiation (GO:0048505)	2.35849940
63	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.35551893
64	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.34435029
65	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.33317832
66	telomere maintenance via telomerase (GO:0007004)	2.32993785
67	cerebral cortex cell migration (GO:0021795)	2.32515022
68	resolution of meiotic recombination intermediates (GO:0000712)	2.30852700
69	positive regulation of mitochondrial fission (GO:0090141)	2.30008250
70	retinal cone cell development (GO:0046549)	2.29310700
71	protein-cofactor linkage (GO:0018065)	2.28885970
72	mechanosensory behavior (GO:0007638)	2.28738345
73	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.27069223
74	protein localization to cilium (GO:0061512)	2.26963004
75	photoreceptor cell maintenance (GO:0045494)	2.26937160
76	glycosphingolipid biosynthetic process (GO:0006688)	2.23136367
77	DNA replication checkpoint (GO:0000076)	2.23124662
78	isoprenoid biosynthetic process (GO:0008299)	2.21870739
79	cilium morphogenesis (GO:0060271)	2.21713595
80	protein K11-linked ubiquitination (GO:0070979)	2.20500272
81	neural tube formation (GO:0001841)	2.20461507
82	peptidyl-histidine modification (GO:0018202)	2.20269337
83	neuron recognition (GO:0008038)	2.19774994
84	histone mRNA metabolic process (GO:0008334)	2.17376378
85	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.17203897
86	postreplication repair (GO:0006301)	2.17001945
87	branched-chain amino acid catabolic process (GO:0009083)	2.16749840
88	regulation of telomere maintenance via telomerase (GO:0032210)	2.16396052
89	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.15161248
90	female gonad development (GO:0008585)	2.15104700
91	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.14791985
92	negative regulation of telomere maintenance (GO:0032205)	2.14642209
93	atrial cardiac muscle cell action potential (GO:0086014)	2.14536854
94	IMP biosynthetic process (GO:0006188)	2.14225237
95	response to pheromone (GO:0019236)	2.13221985
96	cilium organization (GO:0044782)	2.12079757
97	cilium assembly (GO:0042384)	2.11840574
98	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.11464910
99	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.10912766
100	glutamate receptor signaling pathway (GO:0007215)	2.09809834

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.51576862
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.03954456
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.91488800
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.86417204
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.85084327
6	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.65270009
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.58773319
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.58696559
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.49320248
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.44663459
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.40128157
12	FUS_26573619_Chip-Seq_HEK293_Human	2.39781766
13	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.36019976
14	EZH2_22144423_ChIP-Seq_EOC_Human	2.32483027
15	EWS_26573619_Chip-Seq_HEK293_Human	2.32096933
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.26794909
17	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.26118684
18	VDR_22108803_ChIP-Seq_LS180_Human	2.22835663
19	P300_19829295_ChIP-Seq_ESCs_Human	2.08914198
20	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.06239378
21	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.99610630
22	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.97267955
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.94686368
24	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.91803489
25	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.91789458
26	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.88739429
27	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.86191215
28	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.81525404
29	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.71260869
30	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.69042894
31	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.66569242
32	ELK1_19687146_ChIP-ChIP_HELA_Human	1.61728945
33	SMAD4_21799915_ChIP-Seq_A2780_Human	1.59838725
34	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.56122362
35	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.54862052
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.49448730
37	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.49341789
38	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.48533181
39	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.45181842
40	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.45164565
41	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.45110610
42	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.43683359
43	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.38920585
44	MYC_18940864_ChIP-ChIP_HL60_Human	1.37626093
45	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.36818108
46	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.34780278
47	ER_23166858_ChIP-Seq_MCF-7_Human	1.32726620
48	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.32249730
49	RNF2_27304074_Chip-Seq_NSC_Mouse	1.31793583
50	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.30067982
51	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.29154060
52	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.28647053
53	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.28439517
54	AR_25329375_ChIP-Seq_VCAP_Human	1.28140312
55	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.27757358
56	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.27757358
57	CBP_20019798_ChIP-Seq_JUKART_Human	1.27457937
58	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.27457937
59	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.26323805
60	STAT3_23295773_ChIP-Seq_U87_Human	1.26172912
61	AR_21572438_ChIP-Seq_LNCaP_Human	1.25276078
62	BCAT_22108803_ChIP-Seq_LS180_Human	1.24794572
63	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.23043830
64	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.21122162
65	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.18256075
66	IRF1_19129219_ChIP-ChIP_H3396_Human	1.18140866
67	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.17946952
68	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.15450147
69	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.14993883
70	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.14436531
71	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.14248463
72	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.13992282
73	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.13808308
74	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.12761507
75	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.12295580
76	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.11692882
77	TCF4_23295773_ChIP-Seq_U87_Human	1.11586716
78	REST_21632747_ChIP-Seq_MESCs_Mouse	1.10469643
79	TCF4_22108803_ChIP-Seq_LS180_Human	1.09710246
80	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.09614110
81	JUN_21703547_ChIP-Seq_K562_Human	1.05616365
82	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.03014072
83	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.02450431
84	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.01848344
85	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.01840346
86	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.01622773
87	SOX9_26525672_Chip-Seq_HEART_Mouse	1.00694852
88	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.98776332
89	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.97953394
90	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.97743398
91	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.97216737
92	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.97139661
93	P53_22387025_ChIP-Seq_ESCs_Mouse	0.95956286
94	VDR_23849224_ChIP-Seq_CD4+_Human	0.95552958
95	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.95498143
96	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.93542323
97	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.93348677
98	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.93153148
99	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.92920825
100	NANOG_19829295_ChIP-Seq_ESCs_Human	0.92743310

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	2.87659749
2	MP0008877_abnormal_DNA_methylation	2.63851438
3	MP0003122_maternal_imprinting	2.59741474
4	MP0003880_abnormal_central_pattern	2.54313926
5	MP0002736_abnormal_nociception_after	2.48089017
6	MP0001529_abnormal_vocalization	2.08659500
7	MP0003121_genomic_imprinting	2.07616168
8	MP0003941_abnormal_skin_development	2.03480494
9	MP0008789_abnormal_olfactory_epithelium	2.01261196
10	MP0003787_abnormal_imprinting	2.00691126
11	MP0001188_hyperpigmentation	1.94705520
12	MP0000778_abnormal_nervous_system	1.94703924
13	MP0005499_abnormal_olfactory_system	1.91348417
14	MP0005394_taste/olfaction_phenotype	1.91348417
15	MP0001968_abnormal_touch/_nociception	1.89485618
16	MP0003890_abnormal_embryonic-extraembry	1.87586341
17	MP0001984_abnormal_olfaction	1.86571909
18	MP0006072_abnormal_retinal_apoptosis	1.81729455
19	MP0004270_analgesia	1.74856634
20	MP0008058_abnormal_DNA_repair	1.74682570
21	MP0006276_abnormal_autonomic_nervous	1.69747289
22	MP0002102_abnormal_ear_morphology	1.66051614
23	MP0003567_abnormal_fetal_cardiomyocyte	1.65286039
24	MP0002938_white_spotting	1.61505472
25	MP0004133_heterotaxia	1.59371503
26	MP0004859_abnormal_synaptic_plasticity	1.59201089
27	MP0000569_abnormal_digit_pigmentation	1.56187489
28	MP0005551_abnormal_eye_electrophysiolog	1.55006715
29	MP0002272_abnormal_nervous_system	1.54992559
30	MP0009046_muscle_twitch	1.54776851
31	MP0005423_abnormal_somatic_nervous	1.53719245
32	MP0001486_abnormal_startle_reflex	1.52574903
33	MP0003635_abnormal_synaptic_transmissio	1.46316234
34	MP0001293_anophthalmia	1.46101632
35	MP0003195_calcinosis	1.43056666
36	MP0005253_abnormal_eye_physiology	1.42947281
37	MP0002234_abnormal_pharynx_morphology	1.42666069
38	MP0000049_abnormal_middle_ear	1.39412350
39	MP0003693_abnormal_embryo_hatching	1.39087763
40	MP0009745_abnormal_behavioral_response	1.38136752
41	MP0002734_abnormal_mechanical_nocicepti	1.36559639
42	MP0002751_abnormal_autonomic_nervous	1.36407539
43	MP0003011_delayed_dark_adaptation	1.35219282
44	MP0002233_abnormal_nose_morphology	1.32326938
45	MP0000631_abnormal_neuroendocrine_gland	1.30124501
46	MP0003937_abnormal_limbs/digits/tail_de	1.27593641
47	MP0008932_abnormal_embryonic_tissue	1.27233611
48	MP0003119_abnormal_digestive_system	1.24052713
49	MP0002063_abnormal_learning/memory/cond	1.23127723
50	MP0002572_abnormal_emotion/affect_behav	1.22069800
51	MP0002184_abnormal_innervation	1.20391918
52	MP0003136_yellow_coat_color	1.16746296
53	MP0003718_maternal_effect	1.14950830
54	MP0002067_abnormal_sensory_capabilities	1.14733290
55	MP0010094_abnormal_chromosome_stability	1.14608526
56	MP0000566_synostosis	1.13709271
57	MP0002638_abnormal_pupillary_reflex	1.10406431
58	MP0001177_atelectasis	1.09819961
59	MP0002735_abnormal_chemical_nociception	1.09225391
60	MP0002557_abnormal_social/conspecific_i	1.09202939
61	MP0006035_abnormal_mitochondrial_morpho	1.08692111
62	MP0004742_abnormal_vestibular_system	1.08518756
63	MP0003755_abnormal_palate_morphology	1.07536854
64	MP0002090_abnormal_vision	1.06166136
65	MP0005187_abnormal_penis_morphology	1.05875527
66	MP0001286_abnormal_eye_development	1.03439845
67	MP0001485_abnormal_pinna_reflex	1.03348559
68	MP0009697_abnormal_copulation	1.02574405
69	MP0000647_abnormal_sebaceous_gland	1.02418721
70	MP0002752_abnormal_somatic_nervous	1.02129922
71	MP0004215_abnormal_myocardial_fiber	1.01690851
72	MP0002064_seizures	0.99800691
73	MP0000955_abnormal_spinal_cord	0.99003795
74	MP0004142_abnormal_muscle_tone	0.98839704
75	MP0005084_abnormal_gallbladder_morpholo	0.96886256
76	MP0010386_abnormal_urinary_bladder	0.96057160
77	MP0003861_abnormal_nervous_system	0.94526280
78	MP0005195_abnormal_posterior_eye	0.93265315
79	MP0003938_abnormal_ear_development	0.92967494
80	MP0002882_abnormal_neuron_morphology	0.92237661
81	MP0005391_vision/eye_phenotype	0.91931307
82	MP0004885_abnormal_endolymph	0.91260178
83	MP0004957_abnormal_blastocyst_morpholog	0.88405275
84	MP0001970_abnormal_pain_threshold	0.88224909
85	MP0002152_abnormal_brain_morphology	0.86224920
86	MP0001299_abnormal_eye_distance/	0.85750243
87	MP0004811_abnormal_neuron_physiology	0.84667989
88	MP0003137_abnormal_impulse_conducting	0.84382135
89	MP0000427_abnormal_hair_cycle	0.83604741
90	MP0001929_abnormal_gametogenesis	0.81422628
91	MP0000516_abnormal_urinary_system	0.80353251
92	MP0005367_renal/urinary_system_phenotyp	0.80353251
93	MP0003698_abnormal_male_reproductive	0.79798661
94	MP0002733_abnormal_thermal_nociception	0.79567468
95	MP0000579_abnormal_nail_morphology	0.78507281
96	MP0009703_decreased_birth_body	0.77350973
97	MP0002254_reproductive_system_inflammat	0.76945958
98	MP0002210_abnormal_sex_determination	0.76509798
99	MP0005386_behavior/neurological_phenoty	0.76224210
100	MP0004924_abnormal_behavior	0.76224210

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the labia minora (HP:0012880)	4.51980198
2	Hepatoblastoma (HP:0002884)	3.05583773
3	Colon cancer (HP:0003003)	2.90780121
4	Gait imbalance (HP:0002141)	2.84280043
5	Medial flaring of the eyebrow (HP:0010747)	2.82144673
6	True hermaphroditism (HP:0010459)	2.80820710
7	Hyperglycinemia (HP:0002154)	2.79044101
8	Pancreatic fibrosis (HP:0100732)	2.73417887
9	Congenital primary aphakia (HP:0007707)	2.69366593
10	Abnormality of midbrain morphology (HP:0002418)	2.64493069
11	Molar tooth sign on MRI (HP:0002419)	2.64493069
12	Nephrogenic diabetes insipidus (HP:0009806)	2.60711320
13	Methylmalonic acidemia (HP:0002912)	2.59677520
14	Genital tract atresia (HP:0001827)	2.55686655
15	Drooling (HP:0002307)	2.54251800
16	Pancreatic cysts (HP:0001737)	2.53456076
17	Vaginal atresia (HP:0000148)	2.46049930
18	Abnormality of the metopic suture (HP:0005556)	2.43772553
19	Retinal dysplasia (HP:0007973)	2.40410333
20	Nephronophthisis (HP:0000090)	2.40084828
21	Broad-based gait (HP:0002136)	2.38809611
22	Labial hypoplasia (HP:0000066)	2.36124628
23	Hyperventilation (HP:0002883)	2.32620217
24	Septo-optic dysplasia (HP:0100842)	2.29949152
25	Excessive salivation (HP:0003781)	2.24956388
26	Hypoplastic female external genitalia (HP:0012815)	2.24459625
27	Abnormality of glycine metabolism (HP:0010895)	2.22266022
28	Abnormality of serine family amino acid metabolism (HP:0010894)	2.22266022
29	Atonic seizures (HP:0010819)	2.17541772
30	Polyphagia (HP:0002591)	2.17072676
31	Acute necrotizing encephalopathy (HP:0006965)	2.16764561
32	Increased serum pyruvate (HP:0003542)	2.15942179
33	Abnormality of serum amino acid levels (HP:0003112)	2.15772635
34	Ependymoma (HP:0002888)	2.13667405
35	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.12758321
36	Abnormality of glycolysis (HP:0004366)	2.12289709
37	Intestinal atresia (HP:0011100)	2.12006362
38	Lissencephaly (HP:0001339)	2.11800166
39	Acute encephalopathy (HP:0006846)	2.11312330
40	Cortical dysplasia (HP:0002539)	2.10167034
41	Poor coordination (HP:0002370)	2.09049670
42	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.08730381
43	Optic nerve hypoplasia (HP:0000609)	2.07192874
44	Volvulus (HP:0002580)	2.06775618
45	Abolished electroretinogram (ERG) (HP:0000550)	2.06014673
46	Postaxial hand polydactyly (HP:0001162)	2.05529592
47	Sclerocornea (HP:0000647)	2.03413643
48	Focal motor seizures (HP:0011153)	2.02402750
49	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.99412074
50	Progressive macrocephaly (HP:0004481)	1.99251484
51	Broad foot (HP:0001769)	1.98872055
52	Bifid tongue (HP:0010297)	1.98419959
53	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.97816418
54	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.97816418
55	Preaxial hand polydactyly (HP:0001177)	1.97426862
56	Astrocytoma (HP:0009592)	1.97136534
57	Abnormality of the astrocytes (HP:0100707)	1.97136534
58	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.97083770
59	Chronic hepatic failure (HP:0100626)	1.96379324
60	Glioma (HP:0009733)	1.95652265
61	Abnormal hair whorl (HP:0010721)	1.94628613
62	Meckel diverticulum (HP:0002245)	1.92665729
63	Abnormal lung lobation (HP:0002101)	1.91943559
64	Methylmalonic aciduria (HP:0012120)	1.89803127
65	Abnormal biliary tract physiology (HP:0012439)	1.89430670
66	Bile duct proliferation (HP:0001408)	1.89430670
67	Abnormality of the ileum (HP:0001549)	1.89296426
68	Impaired vibration sensation in the lower limbs (HP:0002166)	1.86181723
69	Abnormality of the corticospinal tract (HP:0002492)	1.85669274
70	Specific learning disability (HP:0001328)	1.85260509
71	Myokymia (HP:0002411)	1.84497803
72	Progressive inability to walk (HP:0002505)	1.84475504
73	Dialeptic seizures (HP:0011146)	1.84349918
74	Scrotal hypoplasia (HP:0000046)	1.82789078
75	Narrow forehead (HP:0000341)	1.82615469
76	Abnormal mitochondria in muscle tissue (HP:0008316)	1.80424384
77	Abnormality of the renal medulla (HP:0100957)	1.80120033
78	Focal seizures (HP:0007359)	1.79371563
79	Abnormality of the labia (HP:0000058)	1.78948695
80	Hyperglycinuria (HP:0003108)	1.78762049
81	Anencephaly (HP:0002323)	1.78630604
82	Hypothermia (HP:0002045)	1.77964731
83	Prominent metopic ridge (HP:0005487)	1.77767424
84	Postaxial foot polydactyly (HP:0001830)	1.76958276
85	Hypoplastic labia majora (HP:0000059)	1.76906706
86	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.76497320
87	Abnormality of chromosome stability (HP:0003220)	1.76128493
88	Median cleft lip (HP:0000161)	1.75124716
89	Renal hypoplasia (HP:0000089)	1.74962430
90	Short tibia (HP:0005736)	1.74192753
91	Birth length less than 3rd percentile (HP:0003561)	1.72982112
92	Absent speech (HP:0001344)	1.72591637
93	Exercise-induced muscle cramps (HP:0003710)	1.72129731
94	Dandy-Walker malformation (HP:0001305)	1.70668821
95	Facial hemangioma (HP:0000329)	1.70590484
96	Hyperinsulinemic hypoglycemia (HP:0000825)	1.69987525
97	Hyperalaninemia (HP:0003348)	1.69967198
98	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.69967198
99	Abnormality of alanine metabolism (HP:0010916)	1.69967198
100	Amyotrophic lateral sclerosis (HP:0007354)	1.69398572

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK3	3.85208315
2	CASK	3.78426559
3	MAP4K2	2.96882542
4	TNIK	2.88467887
5	MAP3K4	2.82588450
6	TRIM28	2.53023987
7	MARK1	2.47772667
8	MKNK2	2.35274921
9	MAP2K7	2.20054565
10	BCR	2.07968081
11	TSSK6	2.06881843
12	FRK	2.05397105
13	MAPK13	1.99846066
14	NUAK1	1.90398196
15	SRPK1	1.85925061
16	BMPR1B	1.82996198
17	DYRK2	1.77147283
18	MKNK1	1.75719801
19	PINK1	1.58760758
20	CDC7	1.56550386
21	PLK3	1.54377643
22	CSNK1G1	1.49069511
23	CSNK1G2	1.46071836
24	NEK1	1.45359407
25	ZAK	1.43438473
26	DYRK3	1.42617747
27	PLK4	1.41167893
28	CSNK1G3	1.37632828
29	ERBB3	1.36785228
30	PLK2	1.32669272
31	EPHA4	1.32595861
32	STK38L	1.31508063
33	CSNK1A1L	1.31126400
34	BUB1	1.28562624
35	TTK	1.19268162
36	GRK1	1.18821256
37	EIF2AK3	1.15453544
38	BRSK2	1.13215306
39	ACVR1B	1.11172632
40	VRK1	1.07241160
41	PBK	1.07041553
42	INSRR	1.04928529
43	PAK3	1.04678138
44	PNCK	1.00710507
45	MINK1	0.98750631
46	RPS6KA4	0.98440197
47	WEE1	0.96231491
48	PLK1	0.95302261
49	NTRK2	0.91585410
50	PRKCE	0.85266415
51	NME1	0.83795598
52	PRKCG	0.80744612
53	BCKDK	0.79919825
54	CDK3	0.79087277
55	MAP2K4	0.73113683
56	STK16	0.71347063
57	FGFR2	0.68492715
58	PKN1	0.67292897
59	UHMK1	0.66309702
60	CDK19	0.65833023
61	VRK2	0.64045492
62	CAMK2B	0.63058244
63	MST4	0.60958282
64	CAMK2A	0.60920428
65	ATM	0.60468322
66	SGK223	0.59859634
67	SGK494	0.59859634
68	ATR	0.58061983
69	ADRBK2	0.57611830
70	SGK2	0.56079560
71	TGFBR1	0.54043506
72	FGFR1	0.52995805
73	EPHA3	0.52859347
74	TAF1	0.51298653
75	ERBB4	0.49325367
76	CAMK2D	0.49041425
77	DYRK1A	0.46869143
78	OXSR1	0.45851225
79	CSNK1E	0.44976325
80	CSNK1A1	0.44948118
81	LMTK2	0.43539237
82	EIF2AK1	0.43368061
83	BRD4	0.43012198
84	CAMK2G	0.42934068
85	CHEK2	0.42798796
86	AKT3	0.39851787
87	MAP3K6	0.39423224
88	CDK5	0.38711715
89	BRSK1	0.37032513
90	PRKDC	0.36792784
91	CDK14	0.36227363
92	PRKACA	0.35600773
93	CSNK1D	0.34975605
94	PASK	0.34015267
95	CDK18	0.33110203
96	LIMK1	0.32598224
97	NTRK3	0.32287587
98	OBSCN	0.31442286
99	PRKG1	0.31430026
100	EPHB2	0.30592898

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.72442881
2	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.69884798
3	Protein export_Homo sapiens_hsa03060	2.61217683
4	Steroid biosynthesis_Homo sapiens_hsa00100	2.46512461
5	Propanoate metabolism_Homo sapiens_hsa00640	2.20488371
6	Nicotine addiction_Homo sapiens_hsa05033	2.13986196
7	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.95843715
8	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.93780236
9	Mismatch repair_Homo sapiens_hsa03430	1.92259842
10	RNA polymerase_Homo sapiens_hsa03020	1.88074614
11	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.87340895
12	Non-homologous end-joining_Homo sapiens_hsa03450	1.85849741
13	Oxidative phosphorylation_Homo sapiens_hsa00190	1.76491014
14	Proteasome_Homo sapiens_hsa03050	1.72137559
15	Homologous recombination_Homo sapiens_hsa03440	1.70377783
16	Basal transcription factors_Homo sapiens_hsa03022	1.69405419
17	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.63694916
18	Fatty acid elongation_Homo sapiens_hsa00062	1.63426007
19	Parkinsons disease_Homo sapiens_hsa05012	1.63258280
20	Butanoate metabolism_Homo sapiens_hsa00650	1.61119437
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.60122423
22	Phototransduction_Homo sapiens_hsa04744	1.54143783
23	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.51972783
24	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.50975276
25	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.50339029
26	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.46252299
27	RNA degradation_Homo sapiens_hsa03018	1.45276440
28	Selenocompound metabolism_Homo sapiens_hsa00450	1.41812527
29	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.35612661
30	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.33296356
31	RNA transport_Homo sapiens_hsa03013	1.24496981
32	Huntingtons disease_Homo sapiens_hsa05016	1.22796216
33	Pyruvate metabolism_Homo sapiens_hsa00620	1.21356456
34	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.14524307
35	GABAergic synapse_Homo sapiens_hsa04727	1.08581919
36	DNA replication_Homo sapiens_hsa03030	1.08258749
37	Taste transduction_Homo sapiens_hsa04742	1.03440012
38	Spliceosome_Homo sapiens_hsa03040	1.03352596
39	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.03210511
40	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.02378949
41	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.99280805
42	Oocyte meiosis_Homo sapiens_hsa04114	0.98964213
43	beta-Alanine metabolism_Homo sapiens_hsa00410	0.97972235
44	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.96180936
45	Glutamatergic synapse_Homo sapiens_hsa04724	0.95917346
46	Fatty acid metabolism_Homo sapiens_hsa01212	0.95105534
47	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.94833271
48	Alzheimers disease_Homo sapiens_hsa05010	0.94440084
49	mRNA surveillance pathway_Homo sapiens_hsa03015	0.94215724
50	Peroxisome_Homo sapiens_hsa04146	0.92207140
51	Nucleotide excision repair_Homo sapiens_hsa03420	0.91657686
52	Dopaminergic synapse_Homo sapiens_hsa04728	0.90783196
53	Base excision repair_Homo sapiens_hsa03410	0.90416022
54	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.88502892
55	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.87580523
56	Cell cycle_Homo sapiens_hsa04110	0.87454634
57	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.84992196
58	Cardiac muscle contraction_Homo sapiens_hsa04260	0.84980786
59	Nitrogen metabolism_Homo sapiens_hsa00910	0.84770101
60	Circadian rhythm_Homo sapiens_hsa04710	0.84255988
61	Purine metabolism_Homo sapiens_hsa00230	0.82733575
62	Tryptophan metabolism_Homo sapiens_hsa00380	0.81282387
63	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.79282240
64	Regulation of autophagy_Homo sapiens_hsa04140	0.77341358
65	Morphine addiction_Homo sapiens_hsa05032	0.76263378
66	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.75597209
67	Cocaine addiction_Homo sapiens_hsa05030	0.75013772
68	Pyrimidine metabolism_Homo sapiens_hsa00240	0.74841732
69	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.74041850
70	Circadian entrainment_Homo sapiens_hsa04713	0.72858949
71	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.70848189
72	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.70031843
73	Retinol metabolism_Homo sapiens_hsa00830	0.69044559
74	Fatty acid degradation_Homo sapiens_hsa00071	0.68914044
75	Metabolic pathways_Homo sapiens_hsa01100	0.68238845
76	Amphetamine addiction_Homo sapiens_hsa05031	0.68196224
77	Carbon metabolism_Homo sapiens_hsa01200	0.67981670
78	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.67788363
79	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.66029824
80	Arginine and proline metabolism_Homo sapiens_hsa00330	0.62559671
81	Serotonergic synapse_Homo sapiens_hsa04726	0.61955311
82	Collecting duct acid secretion_Homo sapiens_hsa04966	0.61737037
83	Glutathione metabolism_Homo sapiens_hsa00480	0.61610332
84	Chemical carcinogenesis_Homo sapiens_hsa05204	0.60879215
85	Olfactory transduction_Homo sapiens_hsa04740	0.60378126
86	Hippo signaling pathway_Homo sapiens_hsa04390	0.58203436
87	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.57259265
88	Insulin secretion_Homo sapiens_hsa04911	0.55794730
89	One carbon pool by folate_Homo sapiens_hsa00670	0.55269195
90	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.55058585
91	Ether lipid metabolism_Homo sapiens_hsa00565	0.53325262
92	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.52998584
93	Basal cell carcinoma_Homo sapiens_hsa05217	0.50731020
94	Axon guidance_Homo sapiens_hsa04360	0.50389681
95	Lysine degradation_Homo sapiens_hsa00310	0.48920363
96	Caffeine metabolism_Homo sapiens_hsa00232	0.47054113
97	Long-term depression_Homo sapiens_hsa04730	0.47041259
98	Wnt signaling pathway_Homo sapiens_hsa04310	0.46363479
99	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.42644904
100	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.40623012

ZNF883

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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