ZNF883

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)4.80517316
2DNA double-strand break processing (GO:0000729)4.39938591
3presynaptic membrane organization (GO:0097090)4.34942886
4neuron cell-cell adhesion (GO:0007158)3.82386672
5pyrimidine nucleobase catabolic process (GO:0006208)3.65079842
6nonmotile primary cilium assembly (GO:0035058)3.56988310
7postsynaptic membrane organization (GO:0001941)3.42324980
8negative regulation of translation, ncRNA-mediated (GO:0040033)3.26199030
9regulation of translation, ncRNA-mediated (GO:0045974)3.26199030
10negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.26199030
11vocalization behavior (GO:0071625)3.17162943
12L-serine metabolic process (GO:0006563)3.12308797
13water-soluble vitamin biosynthetic process (GO:0042364)3.10272533
14DNA damage response, detection of DNA damage (GO:0042769)3.07158464
15negative regulation of DNA-dependent DNA replication (GO:2000104)3.05616849
16neurotransmitter-gated ion channel clustering (GO:0072578)3.01622855
17protein neddylation (GO:0045116)3.00613464
18cerebral cortex radially oriented cell migration (GO:0021799)2.93375059
19nucleobase catabolic process (GO:0046113)2.91324227
20chromatin remodeling at centromere (GO:0031055)2.91042757
21cullin deneddylation (GO:0010388)2.87687028
22histone H2A acetylation (GO:0043968)2.87626079
23C4-dicarboxylate transport (GO:0015740)2.86823685
24regulation of mitotic spindle checkpoint (GO:1903504)2.77670513
25regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.77670513
26regulation of meiosis I (GO:0060631)2.74998838
27negative regulation of transcription regulatory region DNA binding (GO:2000678)2.74905927
28CENP-A containing nucleosome assembly (GO:0034080)2.74443810
29limb bud formation (GO:0060174)2.74011215
30regulation of nuclear cell cycle DNA replication (GO:0033262)2.73463508
31negative regulation of DNA recombination (GO:0045910)2.72603223
32olfactory bulb development (GO:0021772)2.72361645
33cholesterol biosynthetic process (GO:0006695)2.69091868
34G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.65326348
35somite development (GO:0061053)2.64653623
36regulation of collateral sprouting (GO:0048670)2.64405596
37somatic diversification of immune receptors via somatic mutation (GO:0002566)2.62764230
38somatic hypermutation of immunoglobulin genes (GO:0016446)2.62764230
39replication fork processing (GO:0031297)2.59331623
40histone exchange (GO:0043486)2.58559895
41DNA replication-dependent nucleosome organization (GO:0034723)2.55966538
42DNA replication-dependent nucleosome assembly (GO:0006335)2.55966538
43retinal ganglion cell axon guidance (GO:0031290)2.55821763
44intraciliary transport (GO:0042073)2.55504801
45sterol biosynthetic process (GO:0016126)2.54469297
46positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.53666642
47respiratory chain complex IV assembly (GO:0008535)2.51406485
48protein localization to synapse (GO:0035418)2.50769635
49protein deneddylation (GO:0000338)2.49078726
50gamma-aminobutyric acid transport (GO:0015812)2.48883429
51regulation of development, heterochronic (GO:0040034)2.48822459
52response to nitrosative stress (GO:0051409)2.47239759
53peptidyl-cysteine modification (GO:0018198)2.46897323
54regulation of helicase activity (GO:0051095)2.46307342
55behavioral response to nicotine (GO:0035095)2.44468528
56DNA catabolic process, exonucleolytic (GO:0000738)2.37761407
57DNA replication-independent nucleosome organization (GO:0034724)2.37641044
58DNA replication-independent nucleosome assembly (GO:0006336)2.37641044
59righting reflex (GO:0060013)2.37364627
60synapse assembly (GO:0007416)2.37100877
61regulation of telomere maintenance (GO:0032204)2.36748242
62regulation of timing of cell differentiation (GO:0048505)2.35849940
63nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.35551893
64exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.34435029
65regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.33317832
66telomere maintenance via telomerase (GO:0007004)2.32993785
67cerebral cortex cell migration (GO:0021795)2.32515022
68resolution of meiotic recombination intermediates (GO:0000712)2.30852700
69positive regulation of mitochondrial fission (GO:0090141)2.30008250
70retinal cone cell development (GO:0046549)2.29310700
71protein-cofactor linkage (GO:0018065)2.28885970
72mechanosensory behavior (GO:0007638)2.28738345
73calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.27069223
74protein localization to cilium (GO:0061512)2.26963004
75photoreceptor cell maintenance (GO:0045494)2.26937160
76glycosphingolipid biosynthetic process (GO:0006688)2.23136367
77DNA replication checkpoint (GO:0000076)2.23124662
78isoprenoid biosynthetic process (GO:0008299)2.21870739
79cilium morphogenesis (GO:0060271)2.21713595
80protein K11-linked ubiquitination (GO:0070979)2.20500272
81neural tube formation (GO:0001841)2.20461507
82peptidyl-histidine modification (GO:0018202)2.20269337
83neuron recognition (GO:0008038)2.19774994
84histone mRNA metabolic process (GO:0008334)2.17376378
85positive regulation of dendritic spine morphogenesis (GO:0061003)2.17203897
86postreplication repair (GO:0006301)2.17001945
87branched-chain amino acid catabolic process (GO:0009083)2.16749840
88regulation of telomere maintenance via telomerase (GO:0032210)2.16396052
89regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.15161248
90female gonad development (GO:0008585)2.15104700
91maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.14791985
92negative regulation of telomere maintenance (GO:0032205)2.14642209
93atrial cardiac muscle cell action potential (GO:0086014)2.14536854
94IMP biosynthetic process (GO:0006188)2.14225237
95response to pheromone (GO:0019236)2.13221985
96cilium organization (GO:0044782)2.12079757
97cilium assembly (GO:0042384)2.11840574
98regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.11464910
99detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.10912766
100glutamate receptor signaling pathway (GO:0007215)2.09809834

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.51576862
2IGF1R_20145208_ChIP-Seq_DFB_Human3.03954456
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.91488800
4ZNF274_21170338_ChIP-Seq_K562_Hela2.86417204
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.85084327
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.65270009
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.58773319
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.58696559
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.49320248
10TAF15_26573619_Chip-Seq_HEK293_Human2.44663459
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.40128157
12FUS_26573619_Chip-Seq_HEK293_Human2.39781766
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.36019976
14EZH2_22144423_ChIP-Seq_EOC_Human2.32483027
15EWS_26573619_Chip-Seq_HEK293_Human2.32096933
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.26794909
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.26118684
18VDR_22108803_ChIP-Seq_LS180_Human2.22835663
19P300_19829295_ChIP-Seq_ESCs_Human2.08914198
20RBPJ_22232070_ChIP-Seq_NCS_Mouse2.06239378
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.99610630
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.97267955
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.94686368
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.91803489
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91789458
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.88739429
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86191215
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.81525404
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.71260869
30POU5F1_16153702_ChIP-ChIP_HESCs_Human1.69042894
31SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66569242
32ELK1_19687146_ChIP-ChIP_HELA_Human1.61728945
33SMAD4_21799915_ChIP-Seq_A2780_Human1.59838725
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56122362
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54862052
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49448730
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49341789
38E2F4_17652178_ChIP-ChIP_JURKAT_Human1.48533181
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.45181842
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45164565
41OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45110610
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43683359
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.38920585
44MYC_18940864_ChIP-ChIP_HL60_Human1.37626093
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.36818108
46NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.34780278
47ER_23166858_ChIP-Seq_MCF-7_Human1.32726620
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32249730
49RNF2_27304074_Chip-Seq_NSC_Mouse1.31793583
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.30067982
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29154060
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28647053
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28439517
54AR_25329375_ChIP-Seq_VCAP_Human1.28140312
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27757358
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27757358
57CBP_20019798_ChIP-Seq_JUKART_Human1.27457937
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27457937
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.26323805
60STAT3_23295773_ChIP-Seq_U87_Human1.26172912
61AR_21572438_ChIP-Seq_LNCaP_Human1.25276078
62BCAT_22108803_ChIP-Seq_LS180_Human1.24794572
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23043830
64KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21122162
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18256075
66IRF1_19129219_ChIP-ChIP_H3396_Human1.18140866
67FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.17946952
68* RUNX2_22187159_ChIP-Seq_PCA_Human1.15450147
69CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.14993883
70RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14436531
71SOX2_16153702_ChIP-ChIP_HESCs_Human1.14248463
72CREB1_15753290_ChIP-ChIP_HEK293T_Human1.13992282
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.13808308
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12761507
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12295580
76KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11692882
77TCF4_23295773_ChIP-Seq_U87_Human1.11586716
78REST_21632747_ChIP-Seq_MESCs_Mouse1.10469643
79TCF4_22108803_ChIP-Seq_LS180_Human1.09710246
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.09614110
81JUN_21703547_ChIP-Seq_K562_Human1.05616365
82BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03014072
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02450431
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01848344
85EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01840346
86NANOG_16153702_ChIP-ChIP_HESCs_Human1.01622773
87SOX9_26525672_Chip-Seq_HEART_Mouse1.00694852
88TAL1_26923725_Chip-Seq_HPCs_Mouse0.98776332
89TBX3_20139965_ChIP-Seq_ESCs_Mouse0.97953394
90NFE2_27457419_Chip-Seq_LIVER_Mouse0.97743398
91TBX3_20139965_ChIP-Seq_MESCs_Mouse0.97216737
92YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97139661
93P53_22387025_ChIP-Seq_ESCs_Mouse0.95956286
94VDR_23849224_ChIP-Seq_CD4+_Human0.95552958
95STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95498143
96TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93542323
97ETS1_20019798_ChIP-Seq_JURKAT_Human0.93348677
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93153148
99FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.92920825
100NANOG_19829295_ChIP-Seq_ESCs_Human0.92743310

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode2.87659749
2MP0008877_abnormal_DNA_methylation2.63851438
3MP0003122_maternal_imprinting2.59741474
4MP0003880_abnormal_central_pattern2.54313926
5MP0002736_abnormal_nociception_after2.48089017
6MP0001529_abnormal_vocalization2.08659500
7MP0003121_genomic_imprinting2.07616168
8MP0003941_abnormal_skin_development2.03480494
9MP0008789_abnormal_olfactory_epithelium2.01261196
10MP0003787_abnormal_imprinting2.00691126
11MP0001188_hyperpigmentation1.94705520
12MP0000778_abnormal_nervous_system1.94703924
13MP0005499_abnormal_olfactory_system1.91348417
14MP0005394_taste/olfaction_phenotype1.91348417
15MP0001968_abnormal_touch/_nociception1.89485618
16MP0003890_abnormal_embryonic-extraembry1.87586341
17MP0001984_abnormal_olfaction1.86571909
18MP0006072_abnormal_retinal_apoptosis1.81729455
19MP0004270_analgesia1.74856634
20MP0008058_abnormal_DNA_repair1.74682570
21MP0006276_abnormal_autonomic_nervous1.69747289
22MP0002102_abnormal_ear_morphology1.66051614
23MP0003567_abnormal_fetal_cardiomyocyte1.65286039
24MP0002938_white_spotting1.61505472
25MP0004133_heterotaxia1.59371503
26MP0004859_abnormal_synaptic_plasticity1.59201089
27MP0000569_abnormal_digit_pigmentation1.56187489
28MP0005551_abnormal_eye_electrophysiolog1.55006715
29MP0002272_abnormal_nervous_system1.54992559
30MP0009046_muscle_twitch1.54776851
31MP0005423_abnormal_somatic_nervous1.53719245
32MP0001486_abnormal_startle_reflex1.52574903
33MP0003635_abnormal_synaptic_transmissio1.46316234
34MP0001293_anophthalmia1.46101632
35MP0003195_calcinosis1.43056666
36MP0005253_abnormal_eye_physiology1.42947281
37MP0002234_abnormal_pharynx_morphology1.42666069
38MP0000049_abnormal_middle_ear1.39412350
39MP0003693_abnormal_embryo_hatching1.39087763
40MP0009745_abnormal_behavioral_response1.38136752
41MP0002734_abnormal_mechanical_nocicepti1.36559639
42MP0002751_abnormal_autonomic_nervous1.36407539
43MP0003011_delayed_dark_adaptation1.35219282
44MP0002233_abnormal_nose_morphology1.32326938
45MP0000631_abnormal_neuroendocrine_gland1.30124501
46MP0003937_abnormal_limbs/digits/tail_de1.27593641
47MP0008932_abnormal_embryonic_tissue1.27233611
48MP0003119_abnormal_digestive_system1.24052713
49MP0002063_abnormal_learning/memory/cond1.23127723
50MP0002572_abnormal_emotion/affect_behav1.22069800
51MP0002184_abnormal_innervation1.20391918
52MP0003136_yellow_coat_color1.16746296
53MP0003718_maternal_effect1.14950830
54MP0002067_abnormal_sensory_capabilities1.14733290
55MP0010094_abnormal_chromosome_stability1.14608526
56MP0000566_synostosis1.13709271
57MP0002638_abnormal_pupillary_reflex1.10406431
58MP0001177_atelectasis1.09819961
59MP0002735_abnormal_chemical_nociception1.09225391
60MP0002557_abnormal_social/conspecific_i1.09202939
61MP0006035_abnormal_mitochondrial_morpho1.08692111
62MP0004742_abnormal_vestibular_system1.08518756
63MP0003755_abnormal_palate_morphology1.07536854
64MP0002090_abnormal_vision1.06166136
65MP0005187_abnormal_penis_morphology1.05875527
66MP0001286_abnormal_eye_development1.03439845
67MP0001485_abnormal_pinna_reflex1.03348559
68MP0009697_abnormal_copulation1.02574405
69MP0000647_abnormal_sebaceous_gland1.02418721
70MP0002752_abnormal_somatic_nervous1.02129922
71MP0004215_abnormal_myocardial_fiber1.01690851
72MP0002064_seizures0.99800691
73MP0000955_abnormal_spinal_cord0.99003795
74MP0004142_abnormal_muscle_tone0.98839704
75MP0005084_abnormal_gallbladder_morpholo0.96886256
76MP0010386_abnormal_urinary_bladder0.96057160
77MP0003861_abnormal_nervous_system0.94526280
78MP0005195_abnormal_posterior_eye0.93265315
79MP0003938_abnormal_ear_development0.92967494
80MP0002882_abnormal_neuron_morphology0.92237661
81MP0005391_vision/eye_phenotype0.91931307
82MP0004885_abnormal_endolymph0.91260178
83MP0004957_abnormal_blastocyst_morpholog0.88405275
84MP0001970_abnormal_pain_threshold0.88224909
85MP0002152_abnormal_brain_morphology0.86224920
86MP0001299_abnormal_eye_distance/0.85750243
87MP0004811_abnormal_neuron_physiology0.84667989
88MP0003137_abnormal_impulse_conducting0.84382135
89MP0000427_abnormal_hair_cycle0.83604741
90MP0001929_abnormal_gametogenesis0.81422628
91MP0000516_abnormal_urinary_system0.80353251
92MP0005367_renal/urinary_system_phenotyp0.80353251
93MP0003698_abnormal_male_reproductive0.79798661
94MP0002733_abnormal_thermal_nociception0.79567468
95MP0000579_abnormal_nail_morphology0.78507281
96MP0009703_decreased_birth_body0.77350973
97MP0002254_reproductive_system_inflammat0.76945958
98MP0002210_abnormal_sex_determination0.76509798
99MP0005386_behavior/neurological_phenoty0.76224210
100MP0004924_abnormal_behavior0.76224210

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.51980198
2Hepatoblastoma (HP:0002884)3.05583773
3Colon cancer (HP:0003003)2.90780121
4Gait imbalance (HP:0002141)2.84280043
5Medial flaring of the eyebrow (HP:0010747)2.82144673
6True hermaphroditism (HP:0010459)2.80820710
7Hyperglycinemia (HP:0002154)2.79044101
8Pancreatic fibrosis (HP:0100732)2.73417887
9Congenital primary aphakia (HP:0007707)2.69366593
10Abnormality of midbrain morphology (HP:0002418)2.64493069
11Molar tooth sign on MRI (HP:0002419)2.64493069
12Nephrogenic diabetes insipidus (HP:0009806)2.60711320
13Methylmalonic acidemia (HP:0002912)2.59677520
14Genital tract atresia (HP:0001827)2.55686655
15Drooling (HP:0002307)2.54251800
16Pancreatic cysts (HP:0001737)2.53456076
17Vaginal atresia (HP:0000148)2.46049930
18Abnormality of the metopic suture (HP:0005556)2.43772553
19Retinal dysplasia (HP:0007973)2.40410333
20Nephronophthisis (HP:0000090)2.40084828
21Broad-based gait (HP:0002136)2.38809611
22Labial hypoplasia (HP:0000066)2.36124628
23Hyperventilation (HP:0002883)2.32620217
24Septo-optic dysplasia (HP:0100842)2.29949152
25Excessive salivation (HP:0003781)2.24956388
26Hypoplastic female external genitalia (HP:0012815)2.24459625
27Abnormality of glycine metabolism (HP:0010895)2.22266022
28Abnormality of serine family amino acid metabolism (HP:0010894)2.22266022
29Atonic seizures (HP:0010819)2.17541772
30Polyphagia (HP:0002591)2.17072676
31Acute necrotizing encephalopathy (HP:0006965)2.16764561
32Increased serum pyruvate (HP:0003542)2.15942179
33Abnormality of serum amino acid levels (HP:0003112)2.15772635
34Ependymoma (HP:0002888)2.13667405
35Aplasia/Hypoplasia of the sternum (HP:0006714)2.12758321
36Abnormality of glycolysis (HP:0004366)2.12289709
37Intestinal atresia (HP:0011100)2.12006362
38Lissencephaly (HP:0001339)2.11800166
39Acute encephalopathy (HP:0006846)2.11312330
40Cortical dysplasia (HP:0002539)2.10167034
41Poor coordination (HP:0002370)2.09049670
42Aplasia/Hypoplasia of the tongue (HP:0010295)2.08730381
43Optic nerve hypoplasia (HP:0000609)2.07192874
44Volvulus (HP:0002580)2.06775618
45Abolished electroretinogram (ERG) (HP:0000550)2.06014673
46Postaxial hand polydactyly (HP:0001162)2.05529592
47Sclerocornea (HP:0000647)2.03413643
48Focal motor seizures (HP:0011153)2.02402750
49Aplasia/Hypoplasia of the tibia (HP:0005772)1.99412074
50Progressive macrocephaly (HP:0004481)1.99251484
51Broad foot (HP:0001769)1.98872055
52Bifid tongue (HP:0010297)1.98419959
53Degeneration of the lateral corticospinal tracts (HP:0002314)1.97816418
54Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.97816418
55Preaxial hand polydactyly (HP:0001177)1.97426862
56Astrocytoma (HP:0009592)1.97136534
57Abnormality of the astrocytes (HP:0100707)1.97136534
58Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.97083770
59Chronic hepatic failure (HP:0100626)1.96379324
60Glioma (HP:0009733)1.95652265
61Abnormal hair whorl (HP:0010721)1.94628613
62Meckel diverticulum (HP:0002245)1.92665729
63Abnormal lung lobation (HP:0002101)1.91943559
64Methylmalonic aciduria (HP:0012120)1.89803127
65Abnormal biliary tract physiology (HP:0012439)1.89430670
66Bile duct proliferation (HP:0001408)1.89430670
67Abnormality of the ileum (HP:0001549)1.89296426
68Impaired vibration sensation in the lower limbs (HP:0002166)1.86181723
69Abnormality of the corticospinal tract (HP:0002492)1.85669274
70Specific learning disability (HP:0001328)1.85260509
71Myokymia (HP:0002411)1.84497803
72Progressive inability to walk (HP:0002505)1.84475504
73Dialeptic seizures (HP:0011146)1.84349918
74Scrotal hypoplasia (HP:0000046)1.82789078
75Narrow forehead (HP:0000341)1.82615469
76Abnormal mitochondria in muscle tissue (HP:0008316)1.80424384
77Abnormality of the renal medulla (HP:0100957)1.80120033
78Focal seizures (HP:0007359)1.79371563
79Abnormality of the labia (HP:0000058)1.78948695
80Hyperglycinuria (HP:0003108)1.78762049
81Anencephaly (HP:0002323)1.78630604
82Hypothermia (HP:0002045)1.77964731
83Prominent metopic ridge (HP:0005487)1.77767424
84Postaxial foot polydactyly (HP:0001830)1.76958276
85Hypoplastic labia majora (HP:0000059)1.76906706
86Aplasia/Hypoplasia of the uvula (HP:0010293)1.76497320
87Abnormality of chromosome stability (HP:0003220)1.76128493
88Median cleft lip (HP:0000161)1.75124716
89Renal hypoplasia (HP:0000089)1.74962430
90Short tibia (HP:0005736)1.74192753
91Birth length less than 3rd percentile (HP:0003561)1.72982112
92Absent speech (HP:0001344)1.72591637
93Exercise-induced muscle cramps (HP:0003710)1.72129731
94Dandy-Walker malformation (HP:0001305)1.70668821
95Facial hemangioma (HP:0000329)1.70590484
96Hyperinsulinemic hypoglycemia (HP:0000825)1.69987525
97Hyperalaninemia (HP:0003348)1.69967198
98Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.69967198
99Abnormality of alanine metabolism (HP:0010916)1.69967198
100Amyotrophic lateral sclerosis (HP:0007354)1.69398572

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK33.85208315
2CASK3.78426559
3MAP4K22.96882542
4TNIK2.88467887
5MAP3K42.82588450
6TRIM282.53023987
7MARK12.47772667
8MKNK22.35274921
9MAP2K72.20054565
10BCR2.07968081
11TSSK62.06881843
12FRK2.05397105
13MAPK131.99846066
14NUAK11.90398196
15SRPK11.85925061
16BMPR1B1.82996198
17DYRK21.77147283
18MKNK11.75719801
19PINK11.58760758
20CDC71.56550386
21PLK31.54377643
22CSNK1G11.49069511
23CSNK1G21.46071836
24NEK11.45359407
25ZAK1.43438473
26DYRK31.42617747
27PLK41.41167893
28CSNK1G31.37632828
29ERBB31.36785228
30PLK21.32669272
31EPHA41.32595861
32STK38L1.31508063
33CSNK1A1L1.31126400
34BUB11.28562624
35TTK1.19268162
36GRK11.18821256
37EIF2AK31.15453544
38BRSK21.13215306
39ACVR1B1.11172632
40VRK11.07241160
41PBK1.07041553
42INSRR1.04928529
43PAK31.04678138
44PNCK1.00710507
45MINK10.98750631
46RPS6KA40.98440197
47WEE10.96231491
48PLK10.95302261
49NTRK20.91585410
50PRKCE0.85266415
51NME10.83795598
52PRKCG0.80744612
53BCKDK0.79919825
54CDK30.79087277
55MAP2K40.73113683
56STK160.71347063
57FGFR20.68492715
58PKN10.67292897
59UHMK10.66309702
60CDK190.65833023
61VRK20.64045492
62CAMK2B0.63058244
63MST40.60958282
64CAMK2A0.60920428
65ATM0.60468322
66SGK2230.59859634
67SGK4940.59859634
68ATR0.58061983
69ADRBK20.57611830
70SGK20.56079560
71TGFBR10.54043506
72FGFR10.52995805
73EPHA30.52859347
74TAF10.51298653
75ERBB40.49325367
76CAMK2D0.49041425
77DYRK1A0.46869143
78OXSR10.45851225
79CSNK1E0.44976325
80CSNK1A10.44948118
81LMTK20.43539237
82EIF2AK10.43368061
83BRD40.43012198
84CAMK2G0.42934068
85CHEK20.42798796
86AKT30.39851787
87MAP3K60.39423224
88CDK50.38711715
89BRSK10.37032513
90PRKDC0.36792784
91CDK140.36227363
92PRKACA0.35600773
93CSNK1D0.34975605
94PASK0.34015267
95CDK180.33110203
96LIMK10.32598224
97NTRK30.32287587
98OBSCN0.31442286
99PRKG10.31430026
100EPHB20.30592898

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.72442881
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.69884798
3Protein export_Homo sapiens_hsa030602.61217683
4Steroid biosynthesis_Homo sapiens_hsa001002.46512461
5Propanoate metabolism_Homo sapiens_hsa006402.20488371
6Nicotine addiction_Homo sapiens_hsa050332.13986196
7Vitamin B6 metabolism_Homo sapiens_hsa007501.95843715
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.93780236
9Mismatch repair_Homo sapiens_hsa034301.92259842
10RNA polymerase_Homo sapiens_hsa030201.88074614
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.87340895
12Non-homologous end-joining_Homo sapiens_hsa034501.85849741
13Oxidative phosphorylation_Homo sapiens_hsa001901.76491014
14Proteasome_Homo sapiens_hsa030501.72137559
15Homologous recombination_Homo sapiens_hsa034401.70377783
16Basal transcription factors_Homo sapiens_hsa030221.69405419
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.63694916
18Fatty acid elongation_Homo sapiens_hsa000621.63426007
19Parkinsons disease_Homo sapiens_hsa050121.63258280
20Butanoate metabolism_Homo sapiens_hsa006501.61119437
21Fanconi anemia pathway_Homo sapiens_hsa034601.60122423
22Phototransduction_Homo sapiens_hsa047441.54143783
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.51972783
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.50975276
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.50339029
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.46252299
27RNA degradation_Homo sapiens_hsa030181.45276440
28Selenocompound metabolism_Homo sapiens_hsa004501.41812527
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.35612661
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.33296356
31RNA transport_Homo sapiens_hsa030131.24496981
32Huntingtons disease_Homo sapiens_hsa050161.22796216
33Pyruvate metabolism_Homo sapiens_hsa006201.21356456
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14524307
35GABAergic synapse_Homo sapiens_hsa047271.08581919
36DNA replication_Homo sapiens_hsa030301.08258749
37Taste transduction_Homo sapiens_hsa047421.03440012
38Spliceosome_Homo sapiens_hsa030401.03352596
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.03210511
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02378949
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.99280805
42Oocyte meiosis_Homo sapiens_hsa041140.98964213
43beta-Alanine metabolism_Homo sapiens_hsa004100.97972235
44Pentose and glucuronate interconversions_Homo sapiens_hsa000400.96180936
45Glutamatergic synapse_Homo sapiens_hsa047240.95917346
46Fatty acid metabolism_Homo sapiens_hsa012120.95105534
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94833271
48Alzheimers disease_Homo sapiens_hsa050100.94440084
49mRNA surveillance pathway_Homo sapiens_hsa030150.94215724
50Peroxisome_Homo sapiens_hsa041460.92207140
51Nucleotide excision repair_Homo sapiens_hsa034200.91657686
52Dopaminergic synapse_Homo sapiens_hsa047280.90783196
53Base excision repair_Homo sapiens_hsa034100.90416022
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88502892
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87580523
56Cell cycle_Homo sapiens_hsa041100.87454634
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84992196
58Cardiac muscle contraction_Homo sapiens_hsa042600.84980786
59Nitrogen metabolism_Homo sapiens_hsa009100.84770101
60Circadian rhythm_Homo sapiens_hsa047100.84255988
61Purine metabolism_Homo sapiens_hsa002300.82733575
62Tryptophan metabolism_Homo sapiens_hsa003800.81282387
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79282240
64Regulation of autophagy_Homo sapiens_hsa041400.77341358
65Morphine addiction_Homo sapiens_hsa050320.76263378
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75597209
67Cocaine addiction_Homo sapiens_hsa050300.75013772
68Pyrimidine metabolism_Homo sapiens_hsa002400.74841732
69Biosynthesis of amino acids_Homo sapiens_hsa012300.74041850
70Circadian entrainment_Homo sapiens_hsa047130.72858949
71Hedgehog signaling pathway_Homo sapiens_hsa043400.70848189
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70031843
73Retinol metabolism_Homo sapiens_hsa008300.69044559
74Fatty acid degradation_Homo sapiens_hsa000710.68914044
75Metabolic pathways_Homo sapiens_hsa011000.68238845
76Amphetamine addiction_Homo sapiens_hsa050310.68196224
77Carbon metabolism_Homo sapiens_hsa012000.67981670
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67788363
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66029824
80Arginine and proline metabolism_Homo sapiens_hsa003300.62559671
81Serotonergic synapse_Homo sapiens_hsa047260.61955311
82Collecting duct acid secretion_Homo sapiens_hsa049660.61737037
83Glutathione metabolism_Homo sapiens_hsa004800.61610332
84Chemical carcinogenesis_Homo sapiens_hsa052040.60879215
85Olfactory transduction_Homo sapiens_hsa047400.60378126
86Hippo signaling pathway_Homo sapiens_hsa043900.58203436
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.57259265
88Insulin secretion_Homo sapiens_hsa049110.55794730
89One carbon pool by folate_Homo sapiens_hsa006700.55269195
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.55058585
91Ether lipid metabolism_Homo sapiens_hsa005650.53325262
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52998584
93Basal cell carcinoma_Homo sapiens_hsa052170.50731020
94Axon guidance_Homo sapiens_hsa043600.50389681
95Lysine degradation_Homo sapiens_hsa003100.48920363
96Caffeine metabolism_Homo sapiens_hsa002320.47054113
97Long-term depression_Homo sapiens_hsa047300.47041259
98Wnt signaling pathway_Homo sapiens_hsa043100.46363479
99Vitamin digestion and absorption_Homo sapiens_hsa049770.42644904
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.40623012

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