ZNF887P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1kinetochore organization (GO:0051383)5.61221855
2mitotic sister chromatid segregation (GO:0000070)5.41580123
3regulation of centriole replication (GO:0046599)5.38126871
4chromatin remodeling at centromere (GO:0031055)5.35390157
5sister chromatid segregation (GO:0000819)5.34369563
6CENP-A containing nucleosome assembly (GO:0034080)5.28486200
7kinetochore assembly (GO:0051382)5.07676740
8mitotic chromosome condensation (GO:0007076)5.04699807
9protein localization to kinetochore (GO:0034501)4.97660955
10DNA replication checkpoint (GO:0000076)4.96088395
11metaphase plate congression (GO:0051310)4.86866387
12telomere maintenance via semi-conservative replication (GO:0032201)4.85572298
13DNA strand elongation involved in DNA replication (GO:0006271)4.84348650
14DNA unwinding involved in DNA replication (GO:0006268)4.74276563
15mitotic sister chromatid cohesion (GO:0007064)4.69105310
16DNA strand elongation (GO:0022616)4.62434135
17protein localization to chromosome, centromeric region (GO:0071459)4.48072338
18regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.44484422
19histone exchange (GO:0043486)4.38084863
20replication fork processing (GO:0031297)4.36608378
21mitotic recombination (GO:0006312)4.35335656
22DNA double-strand break processing (GO:0000729)4.28527993
23telomere maintenance via recombination (GO:0000722)4.27361326
24mitotic metaphase plate congression (GO:0007080)4.27176712
25DNA replication-independent nucleosome assembly (GO:0006336)4.18330747
26DNA replication-independent nucleosome organization (GO:0034724)4.18330747
27regulation of DNA endoreduplication (GO:0032875)4.17122136
28nucleotide-excision repair, DNA gap filling (GO:0006297)4.16360697
29nuclear pore complex assembly (GO:0051292)4.15121058
30spindle checkpoint (GO:0031577)4.11495870
31protein K6-linked ubiquitination (GO:0085020)4.10526643
32synapsis (GO:0007129)4.07869734
33DNA ligation (GO:0006266)4.07478899
34DNA topological change (GO:0006265)4.07451841
35maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.03985819
36establishment of chromosome localization (GO:0051303)4.02505573
37mitotic spindle checkpoint (GO:0071174)3.95800190
38negative regulation of DNA-dependent DNA replication (GO:2000104)3.94940562
39negative regulation of chromosome segregation (GO:0051985)3.90937171
40DNA replication initiation (GO:0006270)3.89688357
41regulation of centrosome cycle (GO:0046605)3.87888275
42negative regulation of mitotic sister chromatid separation (GO:2000816)3.87154181
43negative regulation of sister chromatid segregation (GO:0033046)3.87154181
44negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.87154181
45negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.87154181
46negative regulation of mitotic sister chromatid segregation (GO:0033048)3.87154181
47nuclear pore organization (GO:0006999)3.86685095
48spindle assembly checkpoint (GO:0071173)3.83711434
49mitotic spindle assembly checkpoint (GO:0007094)3.80879578
50regulation of centrosome duplication (GO:0010824)3.80669793
51attachment of spindle microtubules to kinetochore (GO:0008608)3.80544790
52regulation of chromosome segregation (GO:0051983)3.72499311
53protein localization to chromosome (GO:0034502)3.71091186
54regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.71069036
55regulation of mitotic metaphase/anaphase transition (GO:0030071)3.71069036
56mitotic nuclear envelope disassembly (GO:0007077)3.69656350
57somatic diversification of immune receptors via somatic mutation (GO:0002566)3.69272792
58somatic hypermutation of immunoglobulin genes (GO:0016446)3.69272792
59regulation of sister chromatid segregation (GO:0033045)3.67905348
60regulation of mitotic sister chromatid separation (GO:0010965)3.67905348
61regulation of mitotic sister chromatid segregation (GO:0033047)3.67905348
62chromosome segregation (GO:0007059)3.62530856
63double-strand break repair via nonhomologous end joining (GO:0006303)3.62090322
64non-recombinational repair (GO:0000726)3.62090322
65DNA replication-dependent nucleosome organization (GO:0034723)3.61518343
66DNA replication-dependent nucleosome assembly (GO:0006335)3.61518343
67DNA synthesis involved in DNA repair (GO:0000731)3.60887229
68mitotic G2/M transition checkpoint (GO:0044818)3.55476155
69regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.51525812
70resolution of meiotic recombination intermediates (GO:0000712)3.50854368
71telomere maintenance via telomere lengthening (GO:0010833)3.50539801
72centriole replication (GO:0007099)3.50168069
73postreplication repair (GO:0006301)3.50089774
74histone H2A acetylation (GO:0043968)3.48866013
75chromosome condensation (GO:0030261)3.48619917
76translesion synthesis (GO:0019985)3.47488786
77meiotic chromosome segregation (GO:0045132)3.47216160
78membrane disassembly (GO:0030397)3.38004696
79nuclear envelope disassembly (GO:0051081)3.38004696
80regulation of mitotic spindle checkpoint (GO:1903504)3.36825205
81regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.36825205
82regulation of double-strand break repair via homologous recombination (GO:0010569)3.21597632
83DNA packaging (GO:0006323)3.19831557
84DNA catabolic process, exonucleolytic (GO:0000738)3.19213317
85recombinational repair (GO:0000725)3.13704008
86ATP-dependent chromatin remodeling (GO:0043044)3.11806031
87double-strand break repair via homologous recombination (GO:0000724)3.11725638
88negative regulation of mitosis (GO:0045839)3.11028984
89chromatin assembly or disassembly (GO:0006333)3.10204028
90telomere maintenance (GO:0000723)3.09794651
91regulation of sister chromatid cohesion (GO:0007063)3.07063893
92telomere organization (GO:0032200)3.06506358
93positive regulation of chromosome segregation (GO:0051984)3.05085739
94pore complex assembly (GO:0046931)3.04994621
95regulation of mitotic spindle organization (GO:0060236)3.04575380
96negative regulation of DNA recombination (GO:0045910)3.02536778
97regulation of spindle organization (GO:0090224)3.02267921
98establishment of integrated proviral latency (GO:0075713)3.01962411
99mitotic cell cycle (GO:0000278)2.97650042
100purine nucleobase biosynthetic process (GO:0009113)2.95418158

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.79667366
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.81029844
3E2F4_17652178_ChIP-ChIP_JURKAT_Human5.38199288
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.97422300
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.81132539
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.55195778
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.14338564
8AR_21909140_ChIP-Seq_LNCAP_Human2.98142264
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.65000116
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.62723706
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.53260697
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.51275072
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.47675730
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.45354563
15ELK1_19687146_ChIP-ChIP_HELA_Human2.14402982
16PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09458125
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.07143289
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.02509121
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89026816
20ZNF274_21170338_ChIP-Seq_K562_Hela1.88279904
21MYC_19030024_ChIP-ChIP_MESCs_Mouse1.87645918
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.84910855
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.77427578
24VDR_23849224_ChIP-Seq_CD4+_Human1.76878429
25YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76855591
26FOXP3_21729870_ChIP-Seq_TREG_Human1.74753855
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.73998364
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.73577025
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.73255706
30FUS_26573619_Chip-Seq_HEK293_Human1.70064162
31DCP1A_22483619_ChIP-Seq_HELA_Human1.69337434
32PADI4_21655091_ChIP-ChIP_MCF-7_Human1.68402977
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67849676
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.67195290
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.64814911
36EWS_26573619_Chip-Seq_HEK293_Human1.62314528
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62267283
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53777636
39VDR_22108803_ChIP-Seq_LS180_Human1.50332914
40MYC_18358816_ChIP-ChIP_MESCs_Mouse1.49525965
41TTF2_22483619_ChIP-Seq_HELA_Human1.49227355
42MYC_18940864_ChIP-ChIP_HL60_Human1.45698988
43TAF15_26573619_Chip-Seq_HEK293_Human1.42348775
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41228834
45TP63_19390658_ChIP-ChIP_HaCaT_Human1.40562531
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.37906907
47PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.37451234
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37046224
49EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.35086738
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.32819214
51GABP_19822575_ChIP-Seq_HepG2_Human1.29443226
52E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.28948928
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27078331
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.25151626
55XRN2_22483619_ChIP-Seq_HELA_Human1.23793090
56KDM5A_27292631_Chip-Seq_BREAST_Human1.22586083
57SOX2_16153702_ChIP-ChIP_HESCs_Human1.22486498
58E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.22385807
59IRF1_19129219_ChIP-ChIP_H3396_Human1.21588719
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18653215
61NANOG_16153702_ChIP-ChIP_HESCs_Human1.14687503
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13497588
63HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.11600100
64IGF1R_20145208_ChIP-Seq_DFB_Human1.11041169
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10362064
66CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.08914777
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.08035113
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06551770
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.02663100
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01223092
71SRF_21415370_ChIP-Seq_HL-1_Mouse1.01086731
72RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95311571
73ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94157840
74ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92824872
75P300_19829295_ChIP-Seq_ESCs_Human0.91740704
76SOX2_18555785_ChIP-Seq_MESCs_Mouse0.88272066
77PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.86840735
78ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86498359
79NOTCH1_21737748_ChIP-Seq_TLL_Human0.79876507
80ELF1_17652178_ChIP-ChIP_JURKAT_Human0.79639762
81FLI1_27457419_Chip-Seq_LIVER_Mouse0.79481342
82SOX17_20123909_ChIP-Seq_XEN_Mouse0.75574544
83SOX9_26525672_Chip-Seq_HEART_Mouse0.75570490
84CTBP2_25329375_ChIP-Seq_LNCAP_Human0.74835151
85FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.74017716
86SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.73131351
87FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.71589480
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.70907247
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.70630467
90ERG_20887958_ChIP-Seq_HPC-7_Mouse0.69581520
91CTBP1_25329375_ChIP-Seq_LNCAP_Human0.69425438
92NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.69379636
93GBX2_23144817_ChIP-Seq_PC3_Human0.69112016
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.67871055
95CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.66016726
96CIITA_25753668_ChIP-Seq_RAJI_Human0.65949672
97YY1_21170310_ChIP-Seq_MESCs_Mouse0.63196620
98HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.62030982
99TP53_22573176_ChIP-Seq_HFKS_Human0.61934950
100CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.61326220

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.55923591
2MP0008057_abnormal_DNA_replication4.60137607
3MP0008058_abnormal_DNA_repair3.89043661
4MP0003111_abnormal_nucleus_morphology3.77415051
5MP0003693_abnormal_embryo_hatching3.62671732
6MP0004957_abnormal_blastocyst_morpholog3.18702340
7MP0003077_abnormal_cell_cycle3.14916430
8MP0008877_abnormal_DNA_methylation2.67338934
9MP0008932_abnormal_embryonic_tissue2.53733047
10MP0008007_abnormal_cellular_replicative2.16945912
11MP0006292_abnormal_olfactory_placode2.16518111
12MP0000566_synostosis1.97530949
13MP0009697_abnormal_copulation1.96818439
14MP0003718_maternal_effect1.89919295
15MP0002938_white_spotting1.89005141
16MP0003890_abnormal_embryonic-extraembry1.88790483
17MP0002102_abnormal_ear_morphology1.85358388
18MP0010307_abnormal_tumor_latency1.81199249
19MP0003121_genomic_imprinting1.75244111
20MP0008789_abnormal_olfactory_epithelium1.71703240
21MP0003937_abnormal_limbs/digits/tail_de1.70367634
22MP0002736_abnormal_nociception_after1.61089296
23MP0001529_abnormal_vocalization1.56048020
24MP0004147_increased_porphyrin_level1.55057814
25MP0003786_premature_aging1.54409474
26MP0001293_anophthalmia1.53731159
27MP0005499_abnormal_olfactory_system1.52301956
28MP0005394_taste/olfaction_phenotype1.52301956
29MP0006072_abnormal_retinal_apoptosis1.49286672
30MP0000569_abnormal_digit_pigmentation1.47695303
31MP0010030_abnormal_orbit_morphology1.47174246
32MP0002210_abnormal_sex_determination1.43205321
33MP0002233_abnormal_nose_morphology1.38252684
34MP0001730_embryonic_growth_arrest1.36753056
35MP0000350_abnormal_cell_proliferation1.35689759
36MP0003123_paternal_imprinting1.34830350
37MP0001697_abnormal_embryo_size1.33221183
38MP0001929_abnormal_gametogenesis1.32300584
39MP0005248_abnormal_Harderian_gland1.31577884
40MP0002084_abnormal_developmental_patter1.30315405
41MP0001672_abnormal_embryogenesis/_devel1.29293033
42MP0005380_embryogenesis_phenotype1.29293033
43MP0002085_abnormal_embryonic_tissue1.29164433
44MP0002697_abnormal_eye_size1.28193697
45MP0003787_abnormal_imprinting1.27842444
46MP0002234_abnormal_pharynx_morphology1.23350801
47MP0000372_irregular_coat_pigmentation1.21858339
48MP0001984_abnormal_olfaction1.19701548
49MP0010352_gastrointestinal_tract_polyps1.17688804
50MP0004197_abnormal_fetal_growth/weight/1.16127646
51MP0000015_abnormal_ear_pigmentation1.11937435
52MP0001145_abnormal_male_reproductive1.11134482
53MP0000653_abnormal_sex_gland1.08189195
54MP0002080_prenatal_lethality1.05959854
55MP0001286_abnormal_eye_development1.05577356
56MP0000427_abnormal_hair_cycle1.04099455
57MP0003136_yellow_coat_color1.03946376
58MP0005253_abnormal_eye_physiology1.03480778
59MP0000313_abnormal_cell_death1.03228621
60MP0003984_embryonic_growth_retardation1.02864624
61MP0008995_early_reproductive_senescence1.01790918
62MP0002088_abnormal_embryonic_growth/wei1.00461051
63MP0003567_abnormal_fetal_cardiomyocyte0.97889849
64MP0002160_abnormal_reproductive_system0.96573233
65MP0005408_hypopigmentation0.96538209
66MP0003119_abnormal_digestive_system0.94509335
67MP0003861_abnormal_nervous_system0.93237365
68MP0001119_abnormal_female_reproductive0.92620702
69MP0002111_abnormal_tail_morphology0.92202128
70MP0002095_abnormal_skin_pigmentation0.91924776
71MP0000428_abnormal_craniofacial_morphol0.91341961
72MP0003698_abnormal_male_reproductive0.91229350
73MP0003755_abnormal_palate_morphology0.90992499
74MP0000647_abnormal_sebaceous_gland0.90550189
75MP0009672_abnormal_birth_weight0.88874271
76MP0009703_decreased_birth_body0.87613160
77MP0005391_vision/eye_phenotype0.86134894
78MP0001324_abnormal_eye_pigmentation0.85090040
79MP0000383_abnormal_hair_follicle0.82397324
80MP0006035_abnormal_mitochondrial_morpho0.82315048
81MP0000778_abnormal_nervous_system0.80672587
82MP0002751_abnormal_autonomic_nervous0.80528787
83MP0000631_abnormal_neuroendocrine_gland0.77443554
84MP0001968_abnormal_touch/_nociception0.77013612
85MP0005551_abnormal_eye_electrophysiolog0.74448068
86MP0003935_abnormal_craniofacial_develop0.73769026
87MP0001346_abnormal_lacrimal_gland0.71660735
88MP0002092_abnormal_eye_morphology0.71347675
89MP0002282_abnormal_trachea_morphology0.70783841
90MP0005174_abnormal_tail_pigmentation0.69982628
91MP0000358_abnormal_cell_content/0.69906599
92MP0002638_abnormal_pupillary_reflex0.69443064
93MP0003122_maternal_imprinting0.69388575
94MP0003385_abnormal_body_wall0.69323550
95MP0002009_preneoplasia0.67685856
96MP0010678_abnormal_skin_adnexa0.66590977
97MP0002161_abnormal_fertility/fecundity0.66573136
98MP0001188_hyperpigmentation0.66458194
99MP0003880_abnormal_central_pattern0.65325282
100MP0006036_abnormal_mitochondrial_physio0.64597896

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.71862107
2Chromsome breakage (HP:0040012)5.31764852
3Abnormality of chromosome stability (HP:0003220)4.22862772
4Meckel diverticulum (HP:0002245)4.11030464
5Aplasia/Hypoplasia of the uvula (HP:0010293)4.04025985
6Abnormality of the ileum (HP:0001549)3.92729827
7Abnormality of the labia minora (HP:0012880)3.49341505
8Duodenal stenosis (HP:0100867)3.47101079
9Small intestinal stenosis (HP:0012848)3.47101079
10Abnormality of the preputium (HP:0100587)3.42847373
11Volvulus (HP:0002580)3.42153269
12Increased nuchal translucency (HP:0010880)3.38554003
13Birth length less than 3rd percentile (HP:0003561)3.38483955
14Ependymoma (HP:0002888)3.33986933
15Abnormal lung lobation (HP:0002101)3.33861661
16Abnormality of the duodenum (HP:0002246)3.10855685
17Aplasia/Hypoplasia of the sacrum (HP:0008517)3.05822619
18Sloping forehead (HP:0000340)3.02924762
19Abnormality of the astrocytes (HP:0100707)2.97765867
20Astrocytoma (HP:0009592)2.97765867
21Glioma (HP:0009733)2.95133448
22Abnormality of the carotid arteries (HP:0005344)2.92042968
23Colon cancer (HP:0003003)2.90428933
24Ectopic kidney (HP:0000086)2.86485156
25Cortical dysplasia (HP:0002539)2.81564827
26Hypoplastic pelvis (HP:0008839)2.76040508
27Nephroblastoma (Wilms tumor) (HP:0002667)2.71626077
28Medulloblastoma (HP:0002885)2.67875134
29Absent radius (HP:0003974)2.66233500
30Triphalangeal thumb (HP:0001199)2.62931949
31Myelodysplasia (HP:0002863)2.60383849
32Embryonal renal neoplasm (HP:0011794)2.60170625
33Absent forearm bone (HP:0003953)2.47396585
34Aplasia involving forearm bones (HP:0009822)2.47396585
35Oligodactyly (HP:0012165)2.43967064
36Intestinal atresia (HP:0011100)2.43071860
37Oligodactyly (hands) (HP:0001180)2.42252912
38Rhabdomyosarcoma (HP:0002859)2.40923816
39Small hand (HP:0200055)2.38620869
40Clubbing of toes (HP:0100760)2.38095797
41Breast hypoplasia (HP:0003187)2.28652639
42Cafe-au-lait spot (HP:0000957)2.26648059
43Supernumerary spleens (HP:0009799)2.23120466
44Abnormality of cochlea (HP:0000375)2.21534472
45Pancreatic cysts (HP:0001737)2.13335298
46True hermaphroditism (HP:0010459)2.06023658
47Horseshoe kidney (HP:0000085)2.03631341
48Abnormality of chromosome segregation (HP:0002916)2.00137256
49Bifid tongue (HP:0010297)1.99759550
50Neoplasm of the oral cavity (HP:0100649)1.98821655
51Embryonal neoplasm (HP:0002898)1.97279854
52Astigmatism (HP:0000483)1.96579242
53Facial hemangioma (HP:0000329)1.96543630
54High pitched voice (HP:0001620)1.95225265
55Neoplasm of the colon (HP:0100273)1.93717374
56Abnormality of midbrain morphology (HP:0002418)1.92523788
57Molar tooth sign on MRI (HP:0002419)1.92523788
58Aplasia/Hypoplasia of the sternum (HP:0006714)1.92042088
59Pancreatic fibrosis (HP:0100732)1.88621306
60Stenosis of the external auditory canal (HP:0000402)1.86103801
61Hypoplastic female external genitalia (HP:0012815)1.85722000
62Preaxial hand polydactyly (HP:0001177)1.85586362
63Neoplasm of striated muscle (HP:0009728)1.84552651
64Microglossia (HP:0000171)1.84547427
65Aplasia/Hypoplasia of the tongue (HP:0010295)1.84280721
66Abnormality of methionine metabolism (HP:0010901)1.83507707
67Short thumb (HP:0009778)1.80887220
68Arteriovenous malformation (HP:0100026)1.78333743
69Patellar aplasia (HP:0006443)1.78159950
70Carpal bone hypoplasia (HP:0001498)1.75510616
71Reticulocytopenia (HP:0001896)1.74183093
72Oligohydramnios (HP:0001562)1.73375317
73Choanal atresia (HP:0000453)1.72350695
74Agnosia (HP:0010524)1.71384595
75Nephronophthisis (HP:0000090)1.69929839
76Gonadotropin excess (HP:0000837)1.69634344
77Increased serum pyruvate (HP:0003542)1.67766099
78Abnormal spermatogenesis (HP:0008669)1.66287242
79Aganglionic megacolon (HP:0002251)1.63898690
80Postaxial foot polydactyly (HP:0001830)1.63669858
81Congenital primary aphakia (HP:0007707)1.62038025
82Impulsivity (HP:0100710)1.61046036
83Aqueductal stenosis (HP:0002410)1.59842105
84Morphological abnormality of the inner ear (HP:0011390)1.59509278
85Abnormality of the metopic suture (HP:0005556)1.57855359
86Abnormality of glycolysis (HP:0004366)1.57792431
87Aplasia/Hypoplasia of the patella (HP:0006498)1.57067174
88Abnormality of alanine metabolism (HP:0010916)1.55636591
89Hyperalaninemia (HP:0003348)1.55636591
90Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.55636591
91Dandy-Walker malformation (HP:0001305)1.54786138
92Capillary hemangiomas (HP:0005306)1.54334435
93Medial flaring of the eyebrow (HP:0010747)1.53191808
94Abnormality of aspartate family amino acid metabolism (HP:0010899)1.52749848
95Bone marrow hypocellularity (HP:0005528)1.52210666
96Neoplasm of the adrenal cortex (HP:0100641)1.51086894
97Aplasia/Hypoplasia of the tibia (HP:0005772)1.50813016
98Gait imbalance (HP:0002141)1.50488547
99Long clavicles (HP:0000890)1.50331336
100Ovarian neoplasm (HP:0100615)1.50043942

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK44.09985847
2WEE14.05999201
3CDC74.02139352
4BUB13.66824653
5NEK13.61709237
6TTK3.49001238
7SRPK12.69989024
8BRSK22.66686081
9ZAK2.64790225
10WNK32.41191858
11MKNK22.23571055
12PLK32.15550911
13BRD42.12777336
14TSSK62.04712885
15PLK12.03126753
16PBK1.96223185
17MKNK11.94124302
18MST41.93190223
19EIF2AK11.76048062
20ATR1.69086500
21CHEK21.62739490
22CCNB11.51046411
23EIF2AK31.49415838
24CASK1.47384150
25AURKB1.47250650
26PNCK1.46353617
27NEK21.44275159
28BRSK11.42716037
29DYRK31.38922276
30TRIM281.38400614
31ACVR1B1.31064601
32NUAK11.31057547
33BMPR1B1.29736761
34PASK1.20154707
35ATM1.13906723
36VRK11.11698863
37TAF11.10710610
38BRAF1.05330849
39CHEK11.05279150
40MAP4K21.02427539
41STK31.01234953
42EIF2AK21.00704561
43MAP3K41.00287872
44CDK80.95706564
45CDK70.95506019
46EPHA40.94797974
47ERBB40.94233176
48STK160.86666241
49PLK20.84692735
50CSNK1G10.78922985
51MAPK130.75622464
52FRK0.72676609
53AURKA0.72581088
54CDK10.72479405
55CSNK1G30.71726771
56TNIK0.69109197
57SCYL20.68694290
58STK40.66184256
59BCR0.65731639
60TGFBR10.65256127
61CDK30.65116682
62CSNK1G20.60023776
63CDK20.58566630
64ERBB30.57053452
65AKT30.55860903
66VRK20.55216459
67CSNK1A1L0.52535293
68PDK20.52378272
69MAP3K80.50931625
70STK38L0.49168901
71MELK0.47689367
72DYRK20.47275469
73PRKDC0.47177337
74CLK10.46853054
75MET0.45926487
76RPS6KB20.43991792
77NTRK30.43638019
78LATS10.41933074
79TLK10.40855349
80CSNK2A10.40418462
81MAP2K70.38663765
82CSNK2A20.37092277
83INSRR0.35825542
84STK390.35254100
85MAP3K120.34321247
86MINK10.34285338
87MARK10.34224005
88CSNK1E0.33299186
89CDK40.31579084
90CDK180.30883124
91CDK150.27564890
92RPS6KA40.27063236
93FGFR10.25893565
94CSNK1D0.25797851
95CDK11A0.24719793
96GSK3B0.23169429
97PRKCI0.21814878
98AKT20.21300523
99PRKCG0.21032207
100FGFR20.20229370

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.81280499
2Mismatch repair_Homo sapiens_hsa034304.55842630
3Homologous recombination_Homo sapiens_hsa034403.63470825
4Fanconi anemia pathway_Homo sapiens_hsa034603.54254924
5Non-homologous end-joining_Homo sapiens_hsa034503.35907896
6Cell cycle_Homo sapiens_hsa041102.83761032
7Base excision repair_Homo sapiens_hsa034102.73664727
8Nucleotide excision repair_Homo sapiens_hsa034202.70188615
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.56701623
10One carbon pool by folate_Homo sapiens_hsa006702.38860440
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.34105354
12RNA transport_Homo sapiens_hsa030132.28236223
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.28073434
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.23661439
15Basal transcription factors_Homo sapiens_hsa030222.14393845
16Proteasome_Homo sapiens_hsa030502.14352277
17RNA polymerase_Homo sapiens_hsa030202.05536286
18Protein export_Homo sapiens_hsa030602.03291793
19Spliceosome_Homo sapiens_hsa030402.00921966
20Propanoate metabolism_Homo sapiens_hsa006401.90609721
21RNA degradation_Homo sapiens_hsa030181.76848878
22Pyrimidine metabolism_Homo sapiens_hsa002401.76214320
23Steroid biosynthesis_Homo sapiens_hsa001001.58739230
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.55600537
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.40358211
26mRNA surveillance pathway_Homo sapiens_hsa030151.37244365
27Folate biosynthesis_Homo sapiens_hsa007901.30968330
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30655028
29Oocyte meiosis_Homo sapiens_hsa041141.30116327
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.29464359
31p53 signaling pathway_Homo sapiens_hsa041151.22270998
32Butanoate metabolism_Homo sapiens_hsa006501.18532773
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16153196
34Pyruvate metabolism_Homo sapiens_hsa006201.12962239
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.06799147
36Purine metabolism_Homo sapiens_hsa002301.06354282
37Vitamin B6 metabolism_Homo sapiens_hsa007501.03538359
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02758465
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02474151
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94670528
41Selenocompound metabolism_Homo sapiens_hsa004500.94302720
42Lysine degradation_Homo sapiens_hsa003100.91992195
43Fatty acid elongation_Homo sapiens_hsa000620.86283267
44Ribosome_Homo sapiens_hsa030100.84324819
45Glutathione metabolism_Homo sapiens_hsa004800.82825466
46Biosynthesis of amino acids_Homo sapiens_hsa012300.82461953
47Fatty acid metabolism_Homo sapiens_hsa012120.80808455
48Carbon metabolism_Homo sapiens_hsa012000.79909204
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74542838
50Systemic lupus erythematosus_Homo sapiens_hsa053220.73318488
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71450189
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70880910
53Alcoholism_Homo sapiens_hsa050340.69789671
54TGF-beta signaling pathway_Homo sapiens_hsa043500.63707496
55Huntingtons disease_Homo sapiens_hsa050160.62801553
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60424302
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55515036
58MicroRNAs in cancer_Homo sapiens_hsa052060.48312398
59Parkinsons disease_Homo sapiens_hsa050120.46429469
60Phototransduction_Homo sapiens_hsa047440.45029675
61Basal cell carcinoma_Homo sapiens_hsa052170.44747979
62Viral carcinogenesis_Homo sapiens_hsa052030.41402636
63Metabolic pathways_Homo sapiens_hsa011000.41283742
64Hippo signaling pathway_Homo sapiens_hsa043900.40966339
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39900583
66Hedgehog signaling pathway_Homo sapiens_hsa043400.39870265
67Olfactory transduction_Homo sapiens_hsa047400.39509288
68Fatty acid degradation_Homo sapiens_hsa000710.39265087
69Peroxisome_Homo sapiens_hsa041460.35639064
70N-Glycan biosynthesis_Homo sapiens_hsa005100.34920701
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33410388
72Oxidative phosphorylation_Homo sapiens_hsa001900.32642769
73Regulation of autophagy_Homo sapiens_hsa041400.29453600
74Wnt signaling pathway_Homo sapiens_hsa043100.29081473
75Prostate cancer_Homo sapiens_hsa052150.27350879
76Nicotine addiction_Homo sapiens_hsa050330.26519733
77Nitrogen metabolism_Homo sapiens_hsa009100.26509583
78Melanoma_Homo sapiens_hsa052180.25535538
79Colorectal cancer_Homo sapiens_hsa052100.24180959
80Thyroid cancer_Homo sapiens_hsa052160.22772984
81Arginine and proline metabolism_Homo sapiens_hsa003300.21258526
82beta-Alanine metabolism_Homo sapiens_hsa004100.20289288
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.20152491
84Epstein-Barr virus infection_Homo sapiens_hsa051690.19890430
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.18570877
86Taste transduction_Homo sapiens_hsa047420.17027983
87Tryptophan metabolism_Homo sapiens_hsa003800.15769804
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.14420750
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.12727674
90Pentose phosphate pathway_Homo sapiens_hsa000300.12396243
91Small cell lung cancer_Homo sapiens_hsa052220.10526233
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.08221369
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.05552578
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.03794744
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.02044058
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.01920101
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.01866825
98Arginine biosynthesis_Homo sapiens_hsa002200.01745778
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.01482933
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.00927840

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