ZNF890P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cAMP-mediated signaling (GO:0043951)6.29370447
2negative regulation of cell killing (GO:0031342)6.29169609
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.29169609
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.88657450
5positive regulation of gamma-delta T cell activation (GO:0046645)5.86799651
6negative regulation of glycoprotein biosynthetic process (GO:0010561)5.78093965
7negative thymic T cell selection (GO:0045060)5.39295516
8negative T cell selection (GO:0043383)5.36657226
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.15458148
10regulation of gamma-delta T cell differentiation (GO:0045586)5.09124007
11regulation of gamma-delta T cell activation (GO:0046643)4.84990096
12sphingosine metabolic process (GO:0006670)4.82115171
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.57587333
14activated T cell proliferation (GO:0050798)4.53259960
15positive regulation of granulocyte differentiation (GO:0030854)4.44977126
16positive T cell selection (GO:0043368)4.40950825
17regulation of B cell receptor signaling pathway (GO:0050855)4.27602078
18T cell selection (GO:0045058)4.26225227
19tolerance induction (GO:0002507)4.23165993
20diol metabolic process (GO:0034311)4.20687272
21positive thymic T cell selection (GO:0045059)4.17744770
22thymic T cell selection (GO:0045061)4.16992651
23response to interleukin-15 (GO:0070672)4.14317851
24negative regulation of T cell mediated immunity (GO:0002710)4.08916831
25antigen processing and presentation of endogenous antigen (GO:0019883)4.06207286
26negative regulation of glycoprotein metabolic process (GO:1903019)4.01386317
27negative regulation of lymphocyte mediated immunity (GO:0002707)3.92693987
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.90351386
29regulation of protein glycosylation (GO:0060049)3.85694214
30positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.83581021
31cellular response to interleukin-15 (GO:0071350)3.83344684
32signal complex assembly (GO:0007172)3.82364871
33leukocyte aggregation (GO:0070486)3.80519730
34regulation of regulatory T cell differentiation (GO:0045589)3.78294226
35opioid receptor signaling pathway (GO:0038003)3.76655867
36regulation of T cell mediated cytotoxicity (GO:0001914)3.72048662
37positive regulation of T cell mediated cytotoxicity (GO:0001916)3.68431552
38sphingoid metabolic process (GO:0046519)3.55894766
39T cell migration (GO:0072678)3.54344747
40regulation of isotype switching to IgG isotypes (GO:0048302)3.36931417
41regulation of T cell tolerance induction (GO:0002664)3.34703167
42B cell receptor signaling pathway (GO:0050853)3.31607845
43negative regulation of leukocyte mediated immunity (GO:0002704)3.31215071
44regulation of alpha-beta T cell proliferation (GO:0046640)3.23179311
45regulation of granulocyte differentiation (GO:0030852)3.21981758
46interferon-gamma secretion (GO:0072643)3.19710759
47piRNA metabolic process (GO:0034587)3.18663472
48positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.09468053
49interferon-gamma production (GO:0032609)3.08566591
50adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.06588675
51negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.95317553
52modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.94264876
53positive regulation by organism of defense response of other organism involved in symbiotic interact2.94264876
54modulation by symbiont of host immune response (GO:0052553)2.94264876
55positive regulation by symbiont of host defense response (GO:0052509)2.94264876
56modulation by symbiont of host defense response (GO:0052031)2.94264876
57modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.94264876
58regulation of defense response to virus by virus (GO:0050690)2.94100071
59positive regulation of alpha-beta T cell proliferation (GO:0046641)2.92514901
60positive regulation of isotype switching (GO:0045830)2.91895171
61regulation of tolerance induction (GO:0002643)2.91145818
62regulation of B cell differentiation (GO:0045577)2.89642461
63antigen receptor-mediated signaling pathway (GO:0050851)2.88837771
64positive regulation of humoral immune response (GO:0002922)2.84645622
65phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.84633667
66regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.83466409
67behavioral response to ethanol (GO:0048149)2.83172649
68positive regulation of B cell differentiation (GO:0045579)2.80738771
69negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.80457937
70pyrimidine nucleobase catabolic process (GO:0006208)2.80015870
71negative regulation of cytosolic calcium ion concentration (GO:0051481)2.79562316
72positive regulation of T cell mediated immunity (GO:0002711)2.79359874
73T cell receptor signaling pathway (GO:0050852)2.78778813
74negative regulation of interleukin-12 production (GO:0032695)2.77997565
75alpha-beta T cell differentiation (GO:0046632)2.77449266
76regulation of T cell mediated immunity (GO:0002709)2.76086299
77positive regulation of mast cell activation (GO:0033005)2.75452663
78regulation of isotype switching (GO:0045191)2.74334009
79positive regulation of interleukin-4 production (GO:0032753)2.73978638
80positive regulation of tolerance induction (GO:0002645)2.72332540
81negative regulation of adaptive immune response (GO:0002820)2.72316594
82positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.71109403
83regulation of leukocyte mediated cytotoxicity (GO:0001910)2.70799884
84regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.69936292
85regulation of natural killer cell mediated immunity (GO:0002715)2.69936292
86cellular extravasation (GO:0045123)2.69789863
87histone H3-K4 trimethylation (GO:0080182)2.69672785
88mast cell activation (GO:0045576)2.68856060
89myeloid dendritic cell activation (GO:0001773)2.68826012
90alpha-beta T cell activation (GO:0046631)2.68636567
91regulation of interleukin-2 biosynthetic process (GO:0045076)2.68517193
92histone H3-K4 methylation (GO:0051568)2.68218235
93regulation of interleukin-5 production (GO:0032674)2.67506064
94macrophage activation involved in immune response (GO:0002281)2.66755737
95positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.61679809
96histone H3-K36 demethylation (GO:0070544)2.61497118
97positive regulation of DNA recombination (GO:0045911)2.59491782
98positive regulation of interleukin-2 production (GO:0032743)2.56016488
99T cell homeostasis (GO:0043029)2.55927811
100response to muramyl dipeptide (GO:0032495)2.54823371

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.69090252
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.65219077
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.84499364
4RUNX_20019798_ChIP-Seq_JUKART_Human3.54936708
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.27633923
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.25338778
7VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human3.16189776
8SCL_19346495_ChIP-Seq_HPC-7_Human2.70671811
9FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.69232920
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.48341715
11MYB_26560356_Chip-Seq_TH2_Human2.46084634
12CIITA_25753668_ChIP-Seq_RAJI_Human2.40864879
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.24360100
14MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.16376193
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.15250082
16MYB_26560356_Chip-Seq_TH1_Human2.14578778
17MYC_22102868_ChIP-Seq_BL_Human2.08035494
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.06584842
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.06529481
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.03777485
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.03086979
22E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.02666239
23GATA3_27048872_Chip-Seq_THYMUS_Human2.00098118
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.89733372
25UTX_26944678_Chip-Seq_JUKART_Human1.86617710
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.84290830
27IRF8_27001747_Chip-Seq_BMDM_Mouse1.76043280
28MAF_26560356_Chip-Seq_TH2_Human1.75096885
29MAF_26560356_Chip-Seq_TH1_Human1.73164194
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.71434544
31SPI1_23127762_ChIP-Seq_K562_Human1.70250976
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.63515713
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.63409817
34KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.61777766
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.58586654
36SPI1_23547873_ChIP-Seq_NB4_Human1.55105709
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.53514591
38LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.51522273
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.51315118
40VDR_21846776_ChIP-Seq_THP-1_Human1.45448653
41NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42560963
42TCF7_22412390_ChIP-Seq_EML_Mouse1.42202607
43GATA1_19941827_ChIP-Seq_MEL_Mouse1.41727929
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37231023
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36929503
46MYB_21317192_ChIP-Seq_ERMYB_Mouse1.35980264
47KDM2B_26808549_Chip-Seq_DND41_Human1.31007856
48GATA3_26560356_Chip-Seq_TH2_Human1.29846408
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.29014914
50GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28373384
51NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.23440914
52VDR_24763502_ChIP-Seq_THP-1_Human1.22672894
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22636637
54DROSHA_22980978_ChIP-Seq_HELA_Human1.21614210
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19798062
56BP1_19119308_ChIP-ChIP_Hs578T_Human1.16491530
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16442130
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15188809
59RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.12136431
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11824988
61VDR_24787735_ChIP-Seq_THP-1_Human1.10376961
62SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09191900
63GATA3_26560356_Chip-Seq_TH1_Human1.07361204
64ELK4_26923725_Chip-Seq_MESODERM_Mouse1.06917740
65GATA1_19941826_ChIP-Seq_K562_Human1.05804006
66KDM2B_26808549_Chip-Seq_JURKAT_Human1.04264331
67PRDM14_20953172_ChIP-Seq_ESCs_Human1.01114276
68BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00557113
69VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00270543
70PKCTHETA_26484144_Chip-Seq_BREAST_Human0.99303021
71LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.98103189
72OCT4_19829295_ChIP-Seq_ESCs_Human0.97083307
73AR_21572438_ChIP-Seq_LNCaP_Human0.96959185
74EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96803715
75RAC3_21632823_ChIP-Seq_H3396_Human0.96569344
76REST_18959480_ChIP-ChIP_MESCs_Mouse0.96125838
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93207287
78CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92079195
79CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91842425
80KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.91477121
81RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.90905615
82CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.90713989
83BCL6_27268052_Chip-Seq_Bcells_Human0.89921712
84PU_27001747_Chip-Seq_BMDM_Mouse0.89616971
85RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88371199
86EGR1_19032775_ChIP-ChIP_M12_Human0.87319560
87FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87119857
88GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87074983
89ELF1_20517297_ChIP-Seq_JURKAT_Human0.86988900
90CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86224186
91CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85068214
92DNAJC2_21179169_ChIP-ChIP_NT2_Human0.84152271
93TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.83857763
94CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83136756
95E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.82993627
96IGF1R_20145208_ChIP-Seq_DFB_Human0.82917964
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82454891
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.82454891
99SMRT_27268052_Chip-Seq_Bcells_Human0.81956373
100SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.81714614

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology3.98913650
2MP0003724_increased_susceptibility_to2.97303967
3MP0009278_abnormal_bone_marrow2.93522960
4MP0005671_abnormal_response_to2.76250948
5MP0003436_decreased_susceptibility_to2.72795026
6MP0001800_abnormal_humoral_immune2.68718393
7MP0003045_fibrosis2.55920840
8MP0001835_abnormal_antigen_presentation2.54100986
9MP0004381_abnormal_hair_follicle2.53598052
10MP0009333_abnormal_splenocyte_physiolog2.43328613
11MP0002653_abnormal_ependyma_morphology2.30350873
12MP0005000_abnormal_immune_tolerance2.24655121
13MP0002420_abnormal_adaptive_immunity2.19373323
14MP0002723_abnormal_immune_serum2.16985098
15MP0001819_abnormal_immune_cell2.14191288
16MP0002452_abnormal_antigen_presenting2.11459335
17MP0000569_abnormal_digit_pigmentation2.05771620
18MP0003866_abnormal_defecation2.04285159
19MP0000703_abnormal_thymus_morphology2.03418149
20MP0000685_abnormal_immune_system2.03040415
21MP0005387_immune_system_phenotype1.96600734
22MP0001790_abnormal_immune_system1.96600734
23MP0003300_gastrointestinal_ulcer1.92302783
24MP0003183_abnormal_peptide_metabolism1.91253847
25MP0005025_abnormal_response_to1.90410600
26MP0002398_abnormal_bone_marrow1.88637867
27MP0008260_abnormal_autophagy1.86051578
28MP0002419_abnormal_innate_immunity1.84955259
29MP0002837_dystrophic_cardiac_calcinosis1.84157396
30MP0000716_abnormal_immune_system1.79940408
31MP0005075_abnormal_melanosome_morpholog1.79442992
32MP0002148_abnormal_hypersensitivity_rea1.72922848
33MP0003303_peritoneal_inflammation1.72049796
34MP0005310_abnormal_salivary_gland1.68590016
35MP0003787_abnormal_imprinting1.65622969
36MP0000015_abnormal_ear_pigmentation1.61265047
37MP0000689_abnormal_spleen_morphology1.59600636
38MP0002722_abnormal_immune_system1.58315141
39MP0003329_amyloid_beta_deposits1.54834113
40MP0003172_abnormal_lysosome_physiology1.54267129
41MP0004859_abnormal_synaptic_plasticity1.52881572
42MP0009785_altered_susceptibility_to1.52823743
43MP0003879_abnormal_hair_cell1.49978985
44MP0002138_abnormal_hepatobiliary_system1.46576167
45MP0006082_CNS_inflammation1.43363163
46MP0006035_abnormal_mitochondrial_morpho1.41602773
47MP0009764_decreased_sensitivity_to1.41514508
48MP0001986_abnormal_taste_sensitivity1.39789642
49MP0003656_abnormal_erythrocyte_physiolo1.35879811
50MP0002405_respiratory_system_inflammati1.35375903
51MP0003221_abnormal_cardiomyocyte_apopto1.34673200
52MP0002429_abnormal_blood_cell1.34551174
53MP0005464_abnormal_platelet_physiology1.33900230
54MP0010155_abnormal_intestine_physiology1.32507282
55MP0001545_abnormal_hematopoietic_system1.29227996
56MP0005397_hematopoietic_system_phenotyp1.29227996
57MP0002396_abnormal_hematopoietic_system1.28555875
58MP0000604_amyloidosis1.18505694
59MP0004883_abnormal_blood_vessel1.17833592
60MP0002132_abnormal_respiratory_system1.16112909
61MP0001845_abnormal_inflammatory_respons1.15540958
62MP0001851_eye_inflammation1.14025921
63MP0004947_skin_inflammation1.11255203
64MP0001873_stomach_inflammation1.11001591
65MP0002928_abnormal_bile_duct1.09677968
66MP0001533_abnormal_skeleton_physiology1.08849439
67MP0004142_abnormal_muscle_tone1.07927749
68MP0008874_decreased_physiological_sensi1.07528803
69MP0005171_absent_coat_pigmentation1.01388852
70MP0002876_abnormal_thyroid_physiology1.00974861
71MP0003646_muscle_fatigue0.99864446
72MP0008961_abnormal_basal_metabolism0.99639820
73MP0003635_abnormal_synaptic_transmissio0.95823607
74MP0000465_gastrointestinal_hemorrhage0.93856355
75MP0003690_abnormal_glial_cell0.93855988
76MP0004130_abnormal_muscle_cell0.93791668
77MP0008569_lethality_at_weaning0.92881223
78MP0003880_abnormal_central_pattern0.92266452
79MP0001968_abnormal_touch/_nociception0.91400442
80MP0003191_abnormal_cellular_cholesterol0.91203626
81MP0004742_abnormal_vestibular_system0.87294899
82MP0001501_abnormal_sleep_pattern0.86860359
83MP0005083_abnormal_biliary_tract0.84994921
84MP0008469_abnormal_protein_level0.83354754
85MP0009765_abnormal_xenobiotic_induced0.81879192
86MP0002063_abnormal_learning/memory/cond0.81204550
87MP0000681_abnormal_thyroid_gland0.78801237
88MP0002933_joint_inflammation0.78313488
89MP0005076_abnormal_cell_differentiation0.77275758
90MP0003091_abnormal_cell_migration0.76867225
91MP0001486_abnormal_startle_reflex0.76110300
92MP0009745_abnormal_behavioral_response0.74900957
93MP0002168_other_aberrant_phenotype0.73310448
94MP0005334_abnormal_fat_pad0.71703376
95MP0002064_seizures0.71418904
96MP0003136_yellow_coat_color0.71055038
97MP0008057_abnormal_DNA_replication0.64230294
98MP0003959_abnormal_lean_body0.63434603
99MP0005670_abnormal_white_adipose0.62462345
100MP0005423_abnormal_somatic_nervous0.61830963

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.89782932
2Thyroid-stimulating hormone excess (HP:0002925)4.84059796
3Stomatitis (HP:0010280)4.48452993
4Myositis (HP:0100614)4.28331065
5Focal motor seizures (HP:0011153)4.27498129
6T lymphocytopenia (HP:0005403)4.22766827
7Elevated erythrocyte sedimentation rate (HP:0003565)4.12875674
8Recurrent bacterial skin infections (HP:0005406)4.03943721
9Spontaneous hematomas (HP:0007420)3.88025392
10Abnormality of T cell number (HP:0011839)3.86403991
11Recurrent abscess formation (HP:0002722)3.75545662
12Orchitis (HP:0100796)3.53501040
13Peripheral hypomyelination (HP:0007182)3.41918601
14Optic neuritis (HP:0100653)3.35810358
15Retrobulbar optic neuritis (HP:0100654)3.35810358
16Gastrointestinal infarctions (HP:0005244)3.08487511
17Pustule (HP:0200039)3.04236335
18Amelogenesis imperfecta (HP:0000705)3.01781172
19Panhypogammaglobulinemia (HP:0003139)2.96724877
20Recurrent fungal infections (HP:0002841)2.96491567
21Abnormality of T cells (HP:0002843)2.91751338
22Mediastinal lymphadenopathy (HP:0100721)2.91222870
23Abnormal delayed hypersensitivity skin test (HP:0002963)2.91190827
24Autoimmune hemolytic anemia (HP:0001890)2.72389584
25Volvulus (HP:0002580)2.72310078
26Amyotrophic lateral sclerosis (HP:0007354)2.71383518
27IgM deficiency (HP:0002850)2.69443143
28Chest pain (HP:0100749)2.64969201
29Abnormality of macrophages (HP:0004311)2.61414468
30Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.59385389
31Parakeratosis (HP:0001036)2.59042512
32Recurrent skin infections (HP:0001581)2.58399261
33Encephalitis (HP:0002383)2.56480978
34Broad alveolar ridges (HP:0000187)2.56112100
35Stomach cancer (HP:0012126)2.51711316
36Ankle clonus (HP:0011448)2.51476901
37Progressive inability to walk (HP:0002505)2.46893222
38Basal cell carcinoma (HP:0002671)2.45715511
39Slow saccadic eye movements (HP:0000514)2.44467657
40Vasculitis (HP:0002633)2.42320350
41Meningitis (HP:0001287)2.35707680
42Verrucae (HP:0200043)2.33348069
43Papilloma (HP:0012740)2.33348069
44Leukocytosis (HP:0001974)2.32258295
45Prolonged bleeding time (HP:0003010)2.30139813
46Agitation (HP:0000713)2.29466780
47Postural instability (HP:0002172)2.28701618
48Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.27809639
49Episodic fever (HP:0001954)2.27598727
50Dialeptic seizures (HP:0011146)2.25314340
51Chronic diarrhea (HP:0002028)2.25058280
52Abnormality of the columella (HP:0009929)2.22360198
53Recurrent cutaneous fungal infections (HP:0011370)2.21142089
54Chronic mucocutaneous candidiasis (HP:0002728)2.21142089
55Papilledema (HP:0001085)2.18837265
56Recurrent viral infections (HP:0004429)2.18449938
57Obstructive lung disease (HP:0006536)2.17947718
58Chronic obstructive pulmonary disease (HP:0006510)2.17947718
59Hemoptysis (HP:0002105)2.17041672
60Increased IgM level (HP:0003496)2.14144099
61Epistaxis (HP:0000421)2.13767945
62Colitis (HP:0002583)2.10862843
63Inflammation of the large intestine (HP:0002037)2.10489672
64Lymphopenia (HP:0001888)2.09779813
65Focal seizures (HP:0007359)2.09657166
66Severe combined immunodeficiency (HP:0004430)2.08950873
67Pulmonary infiltrates (HP:0002113)2.08632376
68Keratoconjunctivitis sicca (HP:0001097)2.06724522
69Gastrointestinal inflammation (HP:0004386)2.05585245
70Gangrene (HP:0100758)2.05481081
71Recurrent sinusitis (HP:0011108)2.05468056
72Abnormality of the fingertips (HP:0001211)2.04509305
73Recurrent gram-negative bacterial infections (HP:0005420)2.03667469
74Gingivitis (HP:0000230)2.03637473
75Gingival bleeding (HP:0000225)1.99654215
76Abnormality of the aortic arch (HP:0012303)1.99173069
77Tented upper lip vermilion (HP:0010804)1.98157283
78Abnormality of T cell physiology (HP:0011840)1.97049636
79IgG deficiency (HP:0004315)1.95524026
80Abnormality of cells of the lymphoid lineage (HP:0012140)1.93177242
81Sepsis (HP:0100806)1.91930830
82Cellulitis (HP:0100658)1.91721263
83Keratoconjunctivitis (HP:0001096)1.90989639
84Spastic gait (HP:0002064)1.90218834
85Abnormality of eosinophils (HP:0001879)1.89647044
86Granulocytopenia (HP:0001913)1.89607373
87Keratitis (HP:0000491)1.88857302
88Amaurosis fugax (HP:0100576)1.87808732
89Truncal obesity (HP:0001956)1.86829489
90Acute hepatic failure (HP:0006554)1.86720280
91Arterial thrombosis (HP:0004420)1.86118321
92Subacute progressive viral hepatitis (HP:0006572)1.84735215
93Acanthocytosis (HP:0001927)1.84037108
94Hypoplasia of the thymus (HP:0000778)1.81008875
95Memory impairment (HP:0002354)1.79695517
96Hypochromic anemia (HP:0001931)1.75476722
97Eosinophilia (HP:0001880)1.74850602
98Pulmonary embolism (HP:0002204)1.72817517
99Urticaria (HP:0001025)1.71383138
100Gaze-evoked nystagmus (HP:0000640)1.70439351

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.38549570
2MAP4K13.43753890
3RIPK42.68750209
4SIK32.58190726
5PRPF4B2.35137054
6TXK2.34097077
7FES2.29554470
8SIK22.24269279
9STK382.23090746
10CAMKK22.13935604
11STK38L1.89378886
12NLK1.83965456
13ITK1.76426259
14KSR21.73854421
15ADRBK21.70696348
16CAMKK11.69913530
17BLK1.66019486
18ZAP701.56027717
19MAP4K21.55708560
20GRK61.55387100
21ERN11.53407457
22CDK191.53065491
23TAOK31.49858786
24IRAK41.42707627
25HCK1.42504048
26BTK1.41624635
27IKBKE1.36475875
28MAP3K131.35085457
29CSK1.31207561
30TYK21.30257712
31JAK31.29821648
32PASK1.28953438
33FRK1.23932070
34MARK21.23640436
35MELK1.22749340
36LCK1.17783434
37CAMK41.16742681
38TNK21.15714321
39TYRO31.15217731
40SYK1.15161638
41MAP2K71.06706220
42JAK11.05281345
43IRAK11.03706872
44EPHB11.02943616
45PRKD21.02837539
46MAP3K41.00271005
47UHMK10.98164716
48TEC0.97929369
49MAP2K20.97235426
50RET0.95798889
51MAP2K30.94841012
52JAK20.94333926
53FGFR40.92239347
54PRKD30.91657751
55PDK10.89882861
56NTRK20.89226754
57PDPK10.88199056
58CSF1R0.87893587
59PINK10.86810244
60MARK30.86057932
61LYN0.84566880
62LATS20.84142621
63GRK70.83444941
64MAP3K90.83302230
65ACVR1B0.79942936
66CDK120.77637808
67MAP3K60.76253724
68BCR0.75868954
69DYRK1B0.73674718
70MAP3K10.73133917
71FGFR30.69338922
72EPHA30.68782651
73ADRBK10.67213704
74MAPK110.67167968
75MAP3K70.61181959
76MAPK130.56456441
77MAP3K140.56151821
78FGR0.55591585
79TGFBR20.53003510
80TBK10.52698302
81IKBKB0.52553709
82MAP3K100.52055791
83TAOK10.49841284
84MAP3K20.48361753
85YES10.47742852
86MAPK120.46858883
87STK110.43839121
88KSR10.42287148
89PRKD10.42011027
90PIM10.41945942
91MAPK70.41774171
92PRKCH0.40914889
93GRK50.40463464
94MAP3K30.39330706
95IRAK30.38428450
96NEK60.37961458
97CDK40.37909716
98CSNK1A1L0.37396617
99PKN20.36607036
100MAP2K40.36223762

Predicted pathways (KEGG)

RankGene SetZ-score
1T cell receptor signaling pathway_Homo sapiens_hsa046602.62267785
2Primary immunodeficiency_Homo sapiens_hsa053402.49401768
3Dorso-ventral axis formation_Homo sapiens_hsa043202.40340396
4Osteoclast differentiation_Homo sapiens_hsa043802.28013583
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.09848511
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.03166834
7Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.91535031
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.90615186
9B cell receptor signaling pathway_Homo sapiens_hsa046621.90390220
10Acute myeloid leukemia_Homo sapiens_hsa052211.87811167
11Morphine addiction_Homo sapiens_hsa050321.64860227
12Allograft rejection_Homo sapiens_hsa053301.58698035
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.58185146
14Phosphatidylinositol signaling system_Homo sapiens_hsa040701.56587113
15Autoimmune thyroid disease_Homo sapiens_hsa053201.55657078
16Nicotine addiction_Homo sapiens_hsa050331.54619769
17Graft-versus-host disease_Homo sapiens_hsa053321.53604535
18Viral myocarditis_Homo sapiens_hsa054161.52562801
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.51274806
20Measles_Homo sapiens_hsa051621.46951502
21Colorectal cancer_Homo sapiens_hsa052101.46940884
22Sphingolipid signaling pathway_Homo sapiens_hsa040711.40517609
23Tuberculosis_Homo sapiens_hsa051521.39032738
24Leishmaniasis_Homo sapiens_hsa051401.38630190
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.38488989
26Chemokine signaling pathway_Homo sapiens_hsa040621.36353532
27Endometrial cancer_Homo sapiens_hsa052131.32081441
28VEGF signaling pathway_Homo sapiens_hsa043701.31061721
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.30056701
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.29796771
31Non-small cell lung cancer_Homo sapiens_hsa052231.24947478
32Type I diabetes mellitus_Homo sapiens_hsa049401.19556848
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.19202383
34Hepatitis B_Homo sapiens_hsa051611.15030735
35Legionellosis_Homo sapiens_hsa051341.12529983
36Hematopoietic cell lineage_Homo sapiens_hsa046401.11105947
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.10325655
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.09887231
39GABAergic synapse_Homo sapiens_hsa047271.08130727
40Herpes simplex infection_Homo sapiens_hsa051681.06815994
41Sphingolipid metabolism_Homo sapiens_hsa006001.05994140
42Pancreatic cancer_Homo sapiens_hsa052121.04836062
43Neurotrophin signaling pathway_Homo sapiens_hsa047221.04475655
44Inositol phosphate metabolism_Homo sapiens_hsa005621.01752236
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.00278497
46FoxO signaling pathway_Homo sapiens_hsa040680.99619346
47Influenza A_Homo sapiens_hsa051640.98763603
48Phototransduction_Homo sapiens_hsa047440.98180189
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.98005099
50Prolactin signaling pathway_Homo sapiens_hsa049170.96854774
51Platelet activation_Homo sapiens_hsa046110.96382004
52Long-term potentiation_Homo sapiens_hsa047200.92917559
53Toxoplasmosis_Homo sapiens_hsa051450.90605520
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89986943
55Renal cell carcinoma_Homo sapiens_hsa052110.89761038
56TNF signaling pathway_Homo sapiens_hsa046680.89666110
57mTOR signaling pathway_Homo sapiens_hsa041500.88175343
58Endocytosis_Homo sapiens_hsa041440.87064932
59Antigen processing and presentation_Homo sapiens_hsa046120.85648548
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84958309
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84045224
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.83437659
63Choline metabolism in cancer_Homo sapiens_hsa052310.82602938
64Phagosome_Homo sapiens_hsa041450.81128428
65ErbB signaling pathway_Homo sapiens_hsa040120.79125676
66Type II diabetes mellitus_Homo sapiens_hsa049300.78938922
67Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78539518
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77967118
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77691802
70Olfactory transduction_Homo sapiens_hsa047400.75680835
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.74451885
72Estrogen signaling pathway_Homo sapiens_hsa049150.73972086
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73881557
74Thyroid cancer_Homo sapiens_hsa052160.73603854
75Taste transduction_Homo sapiens_hsa047420.72986924
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69704911
77Apoptosis_Homo sapiens_hsa042100.69584533
78Cholinergic synapse_Homo sapiens_hsa047250.69262128
79Staphylococcus aureus infection_Homo sapiens_hsa051500.68758444
80Viral carcinogenesis_Homo sapiens_hsa052030.68325406
81Chronic myeloid leukemia_Homo sapiens_hsa052200.67002918
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.62433647
83MAPK signaling pathway_Homo sapiens_hsa040100.62228824
84Hepatitis C_Homo sapiens_hsa051600.62198842
85Salmonella infection_Homo sapiens_hsa051320.62036210
86Synaptic vesicle cycle_Homo sapiens_hsa047210.61989002
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61557894
88Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61222231
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59093397
90HTLV-I infection_Homo sapiens_hsa051660.58950822
91Epstein-Barr virus infection_Homo sapiens_hsa051690.57783842
92GnRH signaling pathway_Homo sapiens_hsa049120.57187298
93Shigellosis_Homo sapiens_hsa051310.54002153
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53481025
95Notch signaling pathway_Homo sapiens_hsa043300.53289585
96Ras signaling pathway_Homo sapiens_hsa040140.51665668
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51645885
98Glutamatergic synapse_Homo sapiens_hsa047240.49133808
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46163597
100Other glycan degradation_Homo sapiens_hsa005110.46073614

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