ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.74188508
2	fucose catabolic process (GO:0019317)	4.15897906
3	L-fucose metabolic process (GO:0042354)	4.15897906
4	L-fucose catabolic process (GO:0042355)	4.15897906
5	response to pheromone (GO:0019236)	3.76113692
6	tryptophan catabolic process (GO:0006569)	3.73327587
7	indole-containing compound catabolic process (GO:0042436)	3.73327587
8	indolalkylamine catabolic process (GO:0046218)	3.73327587
9	indolalkylamine metabolic process (GO:0006586)	3.58289579
10	sulfation (GO:0051923)	3.53976217
11	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.53938121
12	regulation of translation, ncRNA-mediated (GO:0045974)	3.53938121
13	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.53938121
14	kynurenine metabolic process (GO:0070189)	3.50135027
15	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.36865718
16	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.35531219
17	DNA deamination (GO:0045006)	3.33310278
18	gamma-aminobutyric acid transport (GO:0015812)	3.29617463
19	protein polyglutamylation (GO:0018095)	3.28996984
20	cellular ketone body metabolic process (GO:0046950)	3.26931079
21	tryptophan metabolic process (GO:0006568)	3.19326971
22	kidney morphogenesis (GO:0060993)	3.13267616
23	nonmotile primary cilium assembly (GO:0035058)	3.12443270
24	reflex (GO:0060004)	3.11596358
25	detection of light stimulus involved in visual perception (GO:0050908)	3.10486568
26	detection of light stimulus involved in sensory perception (GO:0050962)	3.10486568
27	neuronal action potential (GO:0019228)	3.08258469
28	neural tube formation (GO:0001841)	3.00349626
29	regulation of action potential (GO:0098900)	2.99928704
30	water-soluble vitamin biosynthetic process (GO:0042364)	2.97031397
31	ketone body metabolic process (GO:1902224)	2.93448334
32	indole-containing compound metabolic process (GO:0042430)	2.91398068
33	axoneme assembly (GO:0035082)	2.91118264
34	negative regulation of telomere maintenance (GO:0032205)	2.87820349
35	replication fork processing (GO:0031297)	2.87157014
36	spinal cord motor neuron differentiation (GO:0021522)	2.83919134
37	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.83868031
38	somite development (GO:0061053)	2.83582833
39	piRNA metabolic process (GO:0034587)	2.82726178
40	presynaptic membrane assembly (GO:0097105)	2.81145960
41	epithelial cilium movement (GO:0003351)	2.80366085
42	nephron epithelium morphogenesis (GO:0072088)	2.79864233
43	nephron tubule morphogenesis (GO:0072078)	2.79864233
44	platelet dense granule organization (GO:0060155)	2.75959645
45	protein localization to cilium (GO:0061512)	2.75882809
46	serotonin metabolic process (GO:0042428)	2.72527583
47	protein K11-linked deubiquitination (GO:0035871)	2.71987119
48	behavioral response to ethanol (GO:0048149)	2.70671347
49	primary amino compound metabolic process (GO:1901160)	2.70516689
50	cilium organization (GO:0044782)	2.70436607
51	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.69217544
52	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.67653645
53	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.67653645
54	regulation of posttranscriptional gene silencing (GO:0060147)	2.67633589
55	regulation of gene silencing by miRNA (GO:0060964)	2.67633589
56	regulation of gene silencing by RNA (GO:0060966)	2.67633589
57	DNA double-strand break processing (GO:0000729)	2.67057519
58	regulation of telomere maintenance (GO:0032204)	2.65232746
59	preassembly of GPI anchor in ER membrane (GO:0016254)	2.64935348
60	photoreceptor cell maintenance (GO:0045494)	2.64058291
61	cell proliferation in forebrain (GO:0021846)	2.63475025
62	cornea development in camera-type eye (GO:0061303)	2.63415824
63	cilium assembly (GO:0042384)	2.62324344
64	recombinational repair (GO:0000725)	2.61970109
65	cilium morphogenesis (GO:0060271)	2.61656361
66	double-strand break repair via homologous recombination (GO:0000724)	2.61603740
67	startle response (GO:0001964)	2.61485142
68	negative regulation of mast cell activation (GO:0033004)	2.61183317
69	pyrimidine nucleobase catabolic process (GO:0006208)	2.60682998
70	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.59480166
71	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.58605476
72	cilium or flagellum-dependent cell motility (GO:0001539)	2.58011268
73	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.57613002
74	NADH dehydrogenase complex assembly (GO:0010257)	2.57613002
75	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.57613002
76	cAMP catabolic process (GO:0006198)	2.57056875
77	retinal cone cell development (GO:0046549)	2.53901236
78	peristalsis (GO:0030432)	2.53851404
79	presynaptic membrane organization (GO:0097090)	2.52908245
80	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.52206387
81	DNA methylation involved in gamete generation (GO:0043046)	2.52025519
82	cellular response to ATP (GO:0071318)	2.51487629
83	interkinetic nuclear migration (GO:0022027)	2.50417276
84	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.50017590
85	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.48376635
86	photoreceptor cell development (GO:0042461)	2.47866679
87	reciprocal meiotic recombination (GO:0007131)	2.47660406
88	reciprocal DNA recombination (GO:0035825)	2.47660406
89	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.45387849
90	cilium movement (GO:0003341)	2.44759114
91	positive regulation of fatty acid transport (GO:2000193)	2.44593090
92	transmission of nerve impulse (GO:0019226)	2.44160619
93	protein complex biogenesis (GO:0070271)	2.43007767
94	synaptic transmission, cholinergic (GO:0007271)	2.41548940
95	negative regulation of systemic arterial blood pressure (GO:0003085)	2.40803394
96	regulation of mesoderm development (GO:2000380)	2.40785718
97	membrane depolarization during action potential (GO:0086010)	2.40713392
98	regulation of hippo signaling (GO:0035330)	2.39432829
99	regulation of glucokinase activity (GO:0033131)	2.35580384
100	regulation of hexokinase activity (GO:1903299)	2.35580384

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.75045457
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.25987574
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.21842462
4	VDR_22108803_ChIP-Seq_LS180_Human	3.10766275
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.74978125
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.72918126
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.61831115
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.58281306
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.43172079
10	FUS_26573619_Chip-Seq_HEK293_Human	2.42585932
11	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.39639994
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.34729134
13	EWS_26573619_Chip-Seq_HEK293_Human	2.28592015
14	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.18081535
15	TAF15_26573619_Chip-Seq_HEK293_Human	2.15858642
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.12841321
17	P300_19829295_ChIP-Seq_ESCs_Human	2.04533081
18	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.02112652
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.97902320
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.93934465
21	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.79484363
22	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.78237403
23	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.70103242
24	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.70070987
25	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.68870389
26	IRF1_19129219_ChIP-ChIP_H3396_Human	1.68613031
27	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.66859321
28	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.66754008
29	STAT3_23295773_ChIP-Seq_U87_Human	1.65278807
30	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.64237022
31	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.63164029
32	SMAD4_21799915_ChIP-Seq_A2780_Human	1.61402251
33	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.60770752
34	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.60454872
35	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.59466128
36	BCAT_22108803_ChIP-Seq_LS180_Human	1.58840433
37	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.57193877
38	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.54143928
39	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.51894248
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.50454124
41	CBP_20019798_ChIP-Seq_JUKART_Human	1.50454124
42	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.49366520
43	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.48817218
44	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.48817218
45	TCF4_23295773_ChIP-Seq_U87_Human	1.48077160
46	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.48001502
47	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.47232979
48	AR_25329375_ChIP-Seq_VCAP_Human	1.45617201
49	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.43525240
50	REST_21632747_ChIP-Seq_MESCs_Mouse	1.42599264
51	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.39691783
52	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.36727228
53	RNF2_27304074_Chip-Seq_NSC_Mouse	1.35518281
54	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.35072489
55	TP53_22573176_ChIP-Seq_HFKS_Human	1.33323304
56	AR_21572438_ChIP-Seq_LNCaP_Human	1.32012417
57	MYC_18940864_ChIP-ChIP_HL60_Human	1.26329169
58	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.25813205
59	RUNX2_22187159_ChIP-Seq_PCA_Human	1.24585462
60	TCF4_22108803_ChIP-Seq_LS180_Human	1.23691612
61	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.23501960
62	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.22966054
63	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.22445553
64	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.20470593
65	SOX2_19829295_ChIP-Seq_ESCs_Human	1.20275940
66	NANOG_19829295_ChIP-Seq_ESCs_Human	1.20275940
67	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.20138750
68	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.20041893
69	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.19314631
70	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.17482925
71	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.16739520
72	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.16320356
73	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.16320356
74	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.15943826
75	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.15491135
76	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.14813724
77	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.12790921
78	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.08716607
79	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.08187956
80	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.07439348
81	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.07210201
82	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.07100753
83	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.07081516
84	NCOR_22424771_ChIP-Seq_293T_Human	1.05818296
85	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.03597627
86	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.02851368
87	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.02501074
88	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.02218247
89	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.01751201
90	P53_22387025_ChIP-Seq_ESCs_Mouse	0.99379900
91	TP53_16413492_ChIP-PET_HCT116_Human	0.99354003
92	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.99328173
93	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.99032798
94	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.98971161
95	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.98552760
96	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.97922151
97	HOXB7_26014856_ChIP-Seq_BT474_Human	0.97886005
98	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.94902529
99	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.94894097
100	JUN_21703547_ChIP-Seq_K562_Human	0.93304797

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	2.81975923
2	MP0000569_abnormal_digit_pigmentation	2.64176931
3	MP0003195_calcinosis	2.63201653
4	MP0001968_abnormal_touch/_nociception	2.49014450
5	MP0002102_abnormal_ear_morphology	2.45682939
6	MP0005551_abnormal_eye_electrophysiolog	2.32007189
7	MP0003646_muscle_fatigue	2.17740413
8	MP0009046_muscle_twitch	2.11688841
9	MP0003136_yellow_coat_color	2.10073899
10	MP0006072_abnormal_retinal_apoptosis	2.05822290
11	MP0002837_dystrophic_cardiac_calcinosis	2.03320932
12	MP0006292_abnormal_olfactory_placode	2.02644668
13	MP0001485_abnormal_pinna_reflex	1.97214406
14	MP0003787_abnormal_imprinting	1.95839562
15	MP0009745_abnormal_behavioral_response	1.89086478
16	MP0005174_abnormal_tail_pigmentation	1.85009280
17	MP0002736_abnormal_nociception_after	1.84392869
18	MP0005646_abnormal_pituitary_gland	1.84382861
19	MP0001986_abnormal_taste_sensitivity	1.83927448
20	MP0004142_abnormal_muscle_tone	1.79987891
21	MP0000631_abnormal_neuroendocrine_gland	1.78672954
22	MP0002638_abnormal_pupillary_reflex	1.73838241
23	MP0005253_abnormal_eye_physiology	1.73578957
24	MP0004885_abnormal_endolymph	1.72532198
25	MP0004043_abnormal_pH_regulation	1.70148902
26	MP0002272_abnormal_nervous_system	1.70069558
27	MP0006276_abnormal_autonomic_nervous	1.67053924
28	MP0000427_abnormal_hair_cycle	1.66510759
29	MP0008872_abnormal_physiological_respon	1.66015379
30	MP0003880_abnormal_central_pattern	1.65611682
31	MP0002653_abnormal_ependyma_morphology	1.63171922
32	MP0005645_abnormal_hypothalamus_physiol	1.62528501
33	MP0004145_abnormal_muscle_electrophysio	1.58941335
34	MP0004133_heterotaxia	1.54337944
35	MP0000372_irregular_coat_pigmentation	1.49867229
36	MP0002876_abnormal_thyroid_physiology	1.47949744
37	MP0001486_abnormal_startle_reflex	1.46618327
38	MP0002938_white_spotting	1.46574895
39	MP0001501_abnormal_sleep_pattern	1.46424245
40	MP0002160_abnormal_reproductive_system	1.44842762
41	MP0001984_abnormal_olfaction	1.34851492
42	MP0002064_seizures	1.33647490
43	MP0002735_abnormal_chemical_nociception	1.33218407
44	MP0002572_abnormal_emotion/affect_behav	1.28904527
45	MP0002557_abnormal_social/conspecific_i	1.28883467
46	MP0004742_abnormal_vestibular_system	1.27232203
47	MP0000778_abnormal_nervous_system	1.25094762
48	MP0005389_reproductive_system_phenotype	1.23028747
49	MP0005386_behavior/neurological_phenoty	1.20191590
50	MP0004924_abnormal_behavior	1.20191590
51	MP0002067_abnormal_sensory_capabilities	1.19486467
52	MP0002928_abnormal_bile_duct	1.19171810
53	MP0000383_abnormal_hair_follicle	1.18839958
54	MP0003890_abnormal_embryonic-extraembry	1.17928070
55	MP0005084_abnormal_gallbladder_morpholo	1.15900479
56	MP0005423_abnormal_somatic_nervous	1.15783003
57	MP0003635_abnormal_synaptic_transmissio	1.15186845
58	MP0001529_abnormal_vocalization	1.14603384
59	MP0008875_abnormal_xenobiotic_pharmacok	1.11677159
60	MP0002734_abnormal_mechanical_nocicepti	1.10770223
61	MP0010386_abnormal_urinary_bladder	1.10715832
62	MP0001970_abnormal_pain_threshold	1.10333833
63	MP0002063_abnormal_learning/memory/cond	1.10236917
64	MP0003937_abnormal_limbs/digits/tail_de	1.10011974
65	MP0003121_genomic_imprinting	1.09064727
66	MP0005187_abnormal_penis_morphology	1.08718139
67	MP0002138_abnormal_hepatobiliary_system	1.08523062
68	MP0002095_abnormal_skin_pigmentation	1.07105339
69	MP0005195_abnormal_posterior_eye	1.05543042
70	MP0003119_abnormal_digestive_system	1.02702149
71	MP0003011_delayed_dark_adaptation	1.01024983
72	MP0002751_abnormal_autonomic_nervous	1.00143649
73	MP0002184_abnormal_innervation	0.99167092
74	MP0004215_abnormal_myocardial_fiber	0.98220907
75	MP0002234_abnormal_pharynx_morphology	0.97442394
76	MP0008995_early_reproductive_senescence	0.96995386
77	MP0004147_increased_porphyrin_level	0.95652245
78	MP0002733_abnormal_thermal_nociception	0.94712446
79	MP0002752_abnormal_somatic_nervous	0.93802584
80	MP0001919_abnormal_reproductive_system	0.92296991
81	MP0003878_abnormal_ear_physiology	0.91268025
82	MP0005377_hearing/vestibular/ear_phenot	0.91268025
83	MP0000647_abnormal_sebaceous_gland	0.90330701
84	MP0003283_abnormal_digestive_organ	0.88784116
85	MP0000516_abnormal_urinary_system	0.87618759
86	MP0005367_renal/urinary_system_phenotyp	0.87618759
87	MP0000538_abnormal_urinary_bladder	0.86995241
88	MP0001324_abnormal_eye_pigmentation	0.86661189
89	MP0000230_abnormal_systemic_arterial	0.86405847
90	MP0001188_hyperpigmentation	0.85013215
91	MP0003698_abnormal_male_reproductive	0.84961987
92	MP0000026_abnormal_inner_ear	0.84888134
93	MP0001905_abnormal_dopamine_level	0.84812820
94	MP0008057_abnormal_DNA_replication	0.84731390
95	MP0008058_abnormal_DNA_repair	0.84589823
96	MP0001502_abnormal_circadian_rhythm	0.82584830
97	MP0001963_abnormal_hearing_physiology	0.81623420
98	MP0003567_abnormal_fetal_cardiomyocyte	0.80739281
99	MP0003122_maternal_imprinting	0.80696212
100	MP0000955_abnormal_spinal_cord	0.80380311

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.53042269
2	Molar tooth sign on MRI (HP:0002419)	4.11045946
3	Abnormality of midbrain morphology (HP:0002418)	4.11045946
4	Pancreatic fibrosis (HP:0100732)	4.06253796
5	True hermaphroditism (HP:0010459)	3.91843871
6	Nephronophthisis (HP:0000090)	3.61829117
7	Congenital stationary night blindness (HP:0007642)	3.60001456
8	Hyperventilation (HP:0002883)	3.22528281
9	Abnormality of the renal medulla (HP:0100957)	3.18870360
10	Chronic hepatic failure (HP:0100626)	3.12596264
11	Abnormality of the renal cortex (HP:0011035)	3.04247959
12	Genetic anticipation (HP:0003743)	3.03092408
13	Medial flaring of the eyebrow (HP:0010747)	2.90396934
14	Attenuation of retinal blood vessels (HP:0007843)	2.81528794
15	Type II lissencephaly (HP:0007260)	2.81180051
16	Cystic liver disease (HP:0006706)	2.80390000
17	Gaze-evoked nystagmus (HP:0000640)	2.77433954
18	Progressive cerebellar ataxia (HP:0002073)	2.74845003
19	Abolished electroretinogram (ERG) (HP:0000550)	2.71905541
20	Pendular nystagmus (HP:0012043)	2.65033059
21	Tubular atrophy (HP:0000092)	2.59564507
22	Polydipsia (HP:0001959)	2.54664286
23	Abnormal drinking behavior (HP:0030082)	2.54664286
24	Protruding tongue (HP:0010808)	2.51250868
25	Abnormality of alanine metabolism (HP:0010916)	2.45469239
26	Hyperalaninemia (HP:0003348)	2.45469239
27	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.45469239
28	Sclerocornea (HP:0000647)	2.43861657
29	Broad-based gait (HP:0002136)	2.40126739
30	Gait imbalance (HP:0002141)	2.39725834
31	Furrowed tongue (HP:0000221)	2.36518225
32	Inability to walk (HP:0002540)	2.30477035
33	Congenital primary aphakia (HP:0007707)	2.30411675
34	Anencephaly (HP:0002323)	2.28012054
35	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.25203923
36	Cerebellar dysplasia (HP:0007033)	2.23477049
37	Decreased circulating renin level (HP:0003351)	2.23025455
38	Patellar aplasia (HP:0006443)	2.22620454
39	Large for gestational age (HP:0001520)	2.21448326
40	Abnormal biliary tract physiology (HP:0012439)	2.20920570
41	Bile duct proliferation (HP:0001408)	2.20920570
42	Stomach cancer (HP:0012126)	2.17569276
43	Male pseudohermaphroditism (HP:0000037)	2.16999547
44	Increased corneal curvature (HP:0100692)	2.15372657
45	Keratoconus (HP:0000563)	2.15372657
46	Progressive inability to walk (HP:0002505)	2.15227152
47	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.14783791
48	Aplasia/Hypoplasia of the patella (HP:0006498)	2.14661100
49	Clumsiness (HP:0002312)	2.13554607
50	Nephrogenic diabetes insipidus (HP:0009806)	2.10151185
51	Chorioretinal atrophy (HP:0000533)	2.09728972
52	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.08978871
53	Absent/shortened dynein arms (HP:0200106)	2.08978871
54	Congenital hepatic fibrosis (HP:0002612)	2.08899825
55	Genital tract atresia (HP:0001827)	2.05424736
56	Hypothermia (HP:0002045)	2.04402768
57	Congenital, generalized hypertrichosis (HP:0004540)	2.03330377
58	Febrile seizures (HP:0002373)	2.02906719
59	Vaginal atresia (HP:0000148)	2.01827384
60	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.00950328
61	Renal cortical cysts (HP:0000803)	2.00252363
62	Bony spicule pigmentary retinopathy (HP:0007737)	1.99538541
63	Congenital sensorineural hearing impairment (HP:0008527)	1.99094157
64	Lissencephaly (HP:0001339)	1.96638526
65	Polyuria (HP:0000103)	1.96142417
66	Postaxial foot polydactyly (HP:0001830)	1.95478112
67	Ectopic kidney (HP:0000086)	1.94564923
68	Colon cancer (HP:0003003)	1.93742196
69	Abnormal rod and cone electroretinograms (HP:0008323)	1.93424175
70	Fair hair (HP:0002286)	1.93002402
71	Decreased central vision (HP:0007663)	1.92717480
72	Abnormality of the pons (HP:0007361)	1.92444349
73	Methylmalonic acidemia (HP:0002912)	1.91229212
74	Birth length less than 3rd percentile (HP:0003561)	1.91036572
75	Hypoplasia of the pons (HP:0012110)	1.87430904
76	Small hand (HP:0200055)	1.87378319
77	Concave nail (HP:0001598)	1.86711165
78	Poor coordination (HP:0002370)	1.86568330
79	Absent thumb (HP:0009777)	1.86538857
80	Intestinal atresia (HP:0011100)	1.85123376
81	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.82971234
82	Abnormality of the renal collecting system (HP:0004742)	1.82376784
83	Abnormality of the labia minora (HP:0012880)	1.81812777
84	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.80454633
85	Hemiparesis (HP:0001269)	1.79738029
86	Optic nerve hypoplasia (HP:0000609)	1.79091961
87	Oligodactyly (hands) (HP:0001180)	1.77074393
88	Abnormality of the ileum (HP:0001549)	1.76389957
89	Tachypnea (HP:0002789)	1.76185941
90	Preaxial hand polydactyly (HP:0001177)	1.75441592
91	Thyroiditis (HP:0100646)	1.74400237
92	Absent speech (HP:0001344)	1.71726862
93	Abnormal respiratory epithelium morphology (HP:0012253)	1.70867542
94	Abnormal respiratory motile cilium morphology (HP:0005938)	1.70867542
95	Severe muscular hypotonia (HP:0006829)	1.70802393
96	Dandy-Walker malformation (HP:0001305)	1.70778354
97	Focal motor seizures (HP:0011153)	1.70764963
98	Aplasia/hypoplasia of the uterus (HP:0008684)	1.70732497
99	Meckel diverticulum (HP:0002245)	1.69182483
100	Ketosis (HP:0001946)	1.68872523

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.64104626
2	BMPR1B	3.20443978
3	ADRBK2	2.97929558
4	ACVR1B	2.82789884
5	TLK1	2.60472390
6	ZAK	2.57591990
7	WNK3	2.45869051
8	MAP4K2	2.34739773
9	GRK1	2.27041270
10	INSRR	2.21280236
11	PINK1	2.20471238
12	MAPK13	2.14621092
13	CASK	2.07618003
14	MAP3K4	2.06577331
15	WNK4	2.04604662
16	NUAK1	1.99197085
17	MKNK2	1.87292103
18	TNIK	1.69045227
19	TAOK3	1.49256380
20	STK39	1.43219945
21	OXSR1	1.42077027
22	PNCK	1.36025229
23	MAP2K7	1.25298930
24	FGFR2	1.23641854
25	CAMKK2	1.22499986
26	BRSK2	1.19785202
27	MARK1	1.15759797
28	ADRBK1	1.10539109
29	TGFBR1	1.10147226
30	TXK	1.05744532
31	DAPK2	1.04597733
32	NTRK3	1.00390212
33	MAPKAPK3	1.00337070
34	AKT3	0.95174657
35	MKNK1	0.93094253
36	DYRK2	0.90926278
37	MAPK15	0.90324955
38	PAK3	0.89145261
39	PRKCG	0.83867762
40	STK38L	0.80184369
41	VRK1	0.79124620
42	PRKCE	0.78381100
43	CSNK1G2	0.77548605
44	CSNK1G1	0.76424748
45	NLK	0.76145582
46	WEE1	0.75704332
47	PLK2	0.75583532
48	TEC	0.71518626
49	OBSCN	0.71262867
50	NTRK2	0.69802212
51	TRIM28	0.69562506
52	PIK3CA	0.67176499
53	CSNK1A1L	0.66363467
54	PHKG2	0.64186193
55	PHKG1	0.64186193
56	SGK2	0.62331521
57	CSNK1G3	0.61488266
58	TIE1	0.60472364
59	MAPKAPK5	0.60450863
60	RPS6KA5	0.57486773
61	EPHA4	0.56372876
62	FLT3	0.53904924
63	PTK2B	0.53809175
64	CAMK1G	0.52679491
65	STK11	0.51911423
66	CAMK1	0.50743418
67	MAP2K6	0.49491371
68	BCR	0.48455228
69	PKN1	0.48296369
70	MUSK	0.48076471
71	CAMK2A	0.47893166
72	PLK3	0.46616064
73	PRKCQ	0.46329276
74	NEK2	0.46084916
75	SGK223	0.45217078
76	SGK494	0.45217078
77	CAMK1D	0.44623414
78	ATR	0.44497999
79	CSNK1D	0.43969740
80	TAF1	0.43477722
81	ERBB3	0.41423785
82	PRKACA	0.40708696
83	WNK1	0.40568268
84	ERBB2	0.40439776
85	SIK2	0.39653200
86	PRKAA2	0.39490168
87	MAP2K4	0.38871633
88	CSNK1A1	0.37834181
89	PRKAA1	0.36511614
90	PLK1	0.36399050
91	STK3	0.36036224
92	CDC7	0.35460475
93	IKBKB	0.35074954
94	PRKCZ	0.34949735
95	CAMK4	0.34495468
96	PLK4	0.34029963
97	ATM	0.33792679
98	IRAK1	0.33118202
99	CHEK2	0.32800635
100	TRPM7	0.31487393

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.82106772
2	Nicotine addiction_Homo sapiens_hsa05033	2.67297805
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.61540198
4	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.57087748
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.34529896
6	Butanoate metabolism_Homo sapiens_hsa00650	2.25013178
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.24366672
8	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.19689694
9	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.18367887
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.18125956
11	Fanconi anemia pathway_Homo sapiens_hsa03460	2.12182953
12	Selenocompound metabolism_Homo sapiens_hsa00450	2.05291760
13	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.04918307
14	Homologous recombination_Homo sapiens_hsa03440	2.01736836
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.94439927
16	Taste transduction_Homo sapiens_hsa04742	1.85472701
17	Ether lipid metabolism_Homo sapiens_hsa00565	1.85012550
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.82204689
19	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.80734625
20	RNA polymerase_Homo sapiens_hsa03020	1.78991630
21	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.67056373
22	Tryptophan metabolism_Homo sapiens_hsa00380	1.61548876
23	Morphine addiction_Homo sapiens_hsa05032	1.60281313
24	Basal transcription factors_Homo sapiens_hsa03022	1.54052619
25	Olfactory transduction_Homo sapiens_hsa04740	1.44577203
26	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.42365032
27	Oxidative phosphorylation_Homo sapiens_hsa00190	1.42116850
28	Caffeine metabolism_Homo sapiens_hsa00232	1.28340363
29	Propanoate metabolism_Homo sapiens_hsa00640	1.25813067
30	Circadian entrainment_Homo sapiens_hsa04713	1.25706532
31	RNA degradation_Homo sapiens_hsa03018	1.24937045
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.22076621
33	Protein export_Homo sapiens_hsa03060	1.21688980
34	Insulin secretion_Homo sapiens_hsa04911	1.18740388
35	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.18456702
36	Glutamatergic synapse_Homo sapiens_hsa04724	1.18208979
37	ABC transporters_Homo sapiens_hsa02010	1.18059515
38	GABAergic synapse_Homo sapiens_hsa04727	1.16876637
39	Chemical carcinogenesis_Homo sapiens_hsa05204	1.10169224
40	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.09442891
41	Serotonergic synapse_Homo sapiens_hsa04726	1.09228619
42	Regulation of autophagy_Homo sapiens_hsa04140	1.05616965
43	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.01505594
44	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.00910207
45	Parkinsons disease_Homo sapiens_hsa05012	1.00367958
46	Peroxisome_Homo sapiens_hsa04146	0.98866714
47	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.98797999
48	One carbon pool by folate_Homo sapiens_hsa00670	0.97457149
49	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.93344863
50	Calcium signaling pathway_Homo sapiens_hsa04020	0.91669415
51	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.89088618
52	Retinol metabolism_Homo sapiens_hsa00830	0.88493039
53	Non-homologous end-joining_Homo sapiens_hsa03450	0.87967386
54	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.86280755
55	Cardiac muscle contraction_Homo sapiens_hsa04260	0.81244737
56	Circadian rhythm_Homo sapiens_hsa04710	0.80424720
57	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.80330436
58	Glycerolipid metabolism_Homo sapiens_hsa00561	0.79010855
59	Dopaminergic synapse_Homo sapiens_hsa04728	0.77017282
60	Salivary secretion_Homo sapiens_hsa04970	0.76014624
61	Huntingtons disease_Homo sapiens_hsa05016	0.74243963
62	beta-Alanine metabolism_Homo sapiens_hsa00410	0.73516567
63	Sulfur metabolism_Homo sapiens_hsa00920	0.72930977
64	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.71568753
65	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.67932236
66	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.67230618
67	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.66595663
68	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.65932595
69	Long-term depression_Homo sapiens_hsa04730	0.64785100
70	Purine metabolism_Homo sapiens_hsa00230	0.64378986
71	Alzheimers disease_Homo sapiens_hsa05010	0.64077829
72	Cholinergic synapse_Homo sapiens_hsa04725	0.63906204
73	Fat digestion and absorption_Homo sapiens_hsa04975	0.63059113
74	Histidine metabolism_Homo sapiens_hsa00340	0.62535866
75	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.61668795
76	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.60892615
77	Sulfur relay system_Homo sapiens_hsa04122	0.60292089
78	Amphetamine addiction_Homo sapiens_hsa05031	0.59369933
79	Cocaine addiction_Homo sapiens_hsa05030	0.59212948
80	Asthma_Homo sapiens_hsa05310	0.57276480
81	cAMP signaling pathway_Homo sapiens_hsa04024	0.56308542
82	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.55665882
83	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.52914968
84	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.51950098
85	Primary immunodeficiency_Homo sapiens_hsa05340	0.50771999
86	Basal cell carcinoma_Homo sapiens_hsa05217	0.49009097
87	Renin secretion_Homo sapiens_hsa04924	0.47393390
88	Lysine degradation_Homo sapiens_hsa00310	0.46784470
89	Collecting duct acid secretion_Homo sapiens_hsa04966	0.45772658
90	Metabolic pathways_Homo sapiens_hsa01100	0.43097746
91	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.41563094
92	Type II diabetes mellitus_Homo sapiens_hsa04930	0.41538176
93	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.40201697
94	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.39319781
95	Gastric acid secretion_Homo sapiens_hsa04971	0.37708848
96	Type I diabetes mellitus_Homo sapiens_hsa04940	0.36710345
97	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.35789842
98	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.34264311
99	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.32020285
100	Mineral absorption_Homo sapiens_hsa04978	0.31621049

ZNF891

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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