ZNF90

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.92475781
2energy coupled proton transport, down electrochemical gradient (GO:0015985)4.48990621
3ATP synthesis coupled proton transport (GO:0015986)4.48990621
4water-soluble vitamin biosynthetic process (GO:0042364)4.23197435
5regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.15815344
6regulation of mitotic spindle checkpoint (GO:1903504)4.15815344
7DNA replication checkpoint (GO:0000076)3.97714524
8chaperone-mediated protein transport (GO:0072321)3.91848567
9DNA deamination (GO:0045006)3.82793867
10chromatin remodeling at centromere (GO:0031055)3.79483482
11viral transcription (GO:0019083)3.76979998
12cullin deneddylation (GO:0010388)3.75987008
13translational termination (GO:0006415)3.69695624
14DNA double-strand break processing (GO:0000729)3.68010029
15establishment of protein localization to mitochondrial membrane (GO:0090151)3.67380224
16regulation of posttranscriptional gene silencing (GO:0060147)3.64153674
17regulation of gene silencing by miRNA (GO:0060964)3.64153674
18regulation of gene silencing by RNA (GO:0060966)3.64153674
19mitochondrial respiratory chain complex assembly (GO:0033108)3.59886777
20negative regulation of DNA-dependent DNA replication (GO:2000104)3.58738334
21CENP-A containing nucleosome assembly (GO:0034080)3.53052147
22mitochondrial respiratory chain complex I assembly (GO:0032981)3.51601158
23NADH dehydrogenase complex assembly (GO:0010257)3.51601158
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.51601158
25exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.51559830
26protein complex biogenesis (GO:0070271)3.50823884
27respiratory chain complex IV assembly (GO:0008535)3.50748104
28regulation of nuclear cell cycle DNA replication (GO:0033262)3.48870291
29protein deneddylation (GO:0000338)3.48717734
30ribosomal small subunit biogenesis (GO:0042274)3.47727663
31nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.46008104
32behavioral response to nicotine (GO:0035095)3.44290373
33ribosomal small subunit assembly (GO:0000028)3.43786319
34pseudouridine synthesis (GO:0001522)3.43461609
35replication fork processing (GO:0031297)3.42096159
36SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.37976590
37transcription elongation from RNA polymerase III promoter (GO:0006385)3.37207414
38termination of RNA polymerase III transcription (GO:0006386)3.37207414
39cotranslational protein targeting to membrane (GO:0006613)3.36395777
40mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.35071235
41ribosomal large subunit biogenesis (GO:0042273)3.32579418
42protein-cofactor linkage (GO:0018065)3.29879937
43protein targeting to ER (GO:0045047)3.29724632
44histone exchange (GO:0043486)3.24749551
45maturation of SSU-rRNA (GO:0030490)3.21778018
46translational elongation (GO:0006414)3.17013702
47DNA catabolic process, exonucleolytic (GO:0000738)3.16817093
48cytochrome complex assembly (GO:0017004)3.16676111
49rRNA modification (GO:0000154)3.15660964
50establishment of protein localization to endoplasmic reticulum (GO:0072599)3.13567786
51proteasome assembly (GO:0043248)3.11768753
52protein localization to endoplasmic reticulum (GO:0070972)3.08886458
53regulation of mesoderm development (GO:2000380)3.08511065
54detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.07910517
55recombinational repair (GO:0000725)3.05717500
56protein neddylation (GO:0045116)3.04174816
57RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.03926488
58double-strand break repair via homologous recombination (GO:0000724)3.03024495
59electron transport chain (GO:0022900)3.01316853
60translation (GO:0006412)3.01199717
61rRNA processing (GO:0006364)2.99459451
62respiratory electron transport chain (GO:0022904)2.95998956
63maturation of 5.8S rRNA (GO:0000460)2.95313627
64RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.94920495
65tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.94920495
66rRNA metabolic process (GO:0016072)2.94726454
67translational initiation (GO:0006413)2.91835056
68somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.91651153
69somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.91651153
70isotype switching (GO:0045190)2.91651153
71fucose catabolic process (GO:0019317)2.88149200
72L-fucose metabolic process (GO:0042354)2.88149200
73L-fucose catabolic process (GO:0042355)2.88149200
74rRNA methylation (GO:0031167)2.84980274
75cellular component biogenesis (GO:0044085)2.81235819
76DNA damage response, detection of DNA damage (GO:0042769)2.78316844
77kinetochore assembly (GO:0051382)2.78253599
78tRNA processing (GO:0008033)2.77495430
79mitochondrial RNA metabolic process (GO:0000959)2.77314836
80somatic hypermutation of immunoglobulin genes (GO:0016446)2.77085984
81somatic diversification of immune receptors via somatic mutation (GO:0002566)2.77085984
82protein K6-linked ubiquitination (GO:0085020)2.76910114
83ribonucleoprotein complex biogenesis (GO:0022613)2.76884368
84maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.76667198
85regulation of mitochondrial translation (GO:0070129)2.73198314
86DNA replication-dependent nucleosome assembly (GO:0006335)2.71427440
87DNA replication-dependent nucleosome organization (GO:0034723)2.71427440
88preassembly of GPI anchor in ER membrane (GO:0016254)2.71288806
89histone mRNA metabolic process (GO:0008334)2.70467862
90cellular protein complex disassembly (GO:0043624)2.69771812
91viral life cycle (GO:0019058)2.68487807
92synapsis (GO:0007129)2.68297100
93kidney morphogenesis (GO:0060993)2.68262890
94telomere maintenance via telomerase (GO:0007004)2.68052299
95nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.66147742
96transcription elongation from RNA polymerase I promoter (GO:0006362)2.65139325
97negative regulation of telomere maintenance (GO:0032205)2.62678090
98nucleobase biosynthetic process (GO:0046112)2.62586799
99kinetochore organization (GO:0051383)2.61158911
100spliceosomal snRNP assembly (GO:0000387)2.61122731

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.04620399
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.74879793
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.53902801
4ZNF274_21170338_ChIP-Seq_K562_Hela3.27703178
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.11386632
6* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.99301466
7E2F7_22180533_ChIP-Seq_HELA_Human2.87679786
8VDR_22108803_ChIP-Seq_LS180_Human2.84303984
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.67626354
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.63836709
11ELK1_19687146_ChIP-ChIP_HELA_Human2.53532466
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.45265659
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.42061739
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.37833401
15EWS_26573619_Chip-Seq_HEK293_Human2.31893287
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.31538482
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.26328805
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.23548613
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.21559615
20VDR_23849224_ChIP-Seq_CD4+_Human2.20441590
21MYC_18940864_ChIP-ChIP_HL60_Human2.14096950
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.10114005
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.02097544
24FUS_26573619_Chip-Seq_HEK293_Human1.98992738
25FOXP3_21729870_ChIP-Seq_TREG_Human1.86742179
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.83962312
27POU5F1_16153702_ChIP-ChIP_HESCs_Human1.82946255
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.68291793
29P300_19829295_ChIP-Seq_ESCs_Human1.68040294
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66903180
31TAF15_26573619_Chip-Seq_HEK293_Human1.65705172
32IRF1_19129219_ChIP-ChIP_H3396_Human1.65154982
33IGF1R_20145208_ChIP-Seq_DFB_Human1.62535333
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61177178
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52846815
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50637168
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49994472
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48369623
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45972338
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.45380352
41SOX2_16153702_ChIP-ChIP_HESCs_Human1.43792114
42GBX2_23144817_ChIP-Seq_PC3_Human1.43466935
43MYC_19030024_ChIP-ChIP_MESCs_Mouse1.42803118
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42518926
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.40085553
46MYC_19079543_ChIP-ChIP_MESCs_Mouse1.38592790
47NANOG_16153702_ChIP-ChIP_HESCs_Human1.38492351
48TTF2_22483619_ChIP-Seq_HELA_Human1.37640812
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35950169
50TP53_22573176_ChIP-Seq_HFKS_Human1.34106769
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33404883
52EZH2_22144423_ChIP-Seq_EOC_Human1.32623171
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31856872
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.30575094
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29996960
56GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29690985
57KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.27018027
58KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.27018027
59KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.27018027
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.19080904
61NANOG_19829295_ChIP-Seq_ESCs_Human1.18801379
62SOX2_19829295_ChIP-Seq_ESCs_Human1.18801379
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18547294
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17528698
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16540597
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.16540597
67NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.15105179
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14592859
69E2F1_18555785_ChIP-Seq_MESCs_Mouse1.10681615
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10093262
71RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08332245
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07856245
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07836766
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05371727
75ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04644329
76YY1_21170310_ChIP-Seq_MESCs_Mouse1.04341841
77ER_23166858_ChIP-Seq_MCF-7_Human1.03863213
78CBP_20019798_ChIP-Seq_JUKART_Human1.03618655
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03618655
80E2F1_21310950_ChIP-Seq_MCF-7_Human1.03607453
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.01504612
82ELK1_22589737_ChIP-Seq_MCF10A_Human1.00868900
83BCAT_22108803_ChIP-Seq_LS180_Human1.00785128
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99218614
85SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98917328
86GABP_19822575_ChIP-Seq_HepG2_Human0.98822802
87HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98401510
88DCP1A_22483619_ChIP-Seq_HELA_Human0.97126474
89KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96852651
90TCF4_22108803_ChIP-Seq_LS180_Human0.96438008
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94859158
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94859158
93AR_20517297_ChIP-Seq_VCAP_Human0.93273954
94EZH2_27294783_Chip-Seq_NPCs_Mouse0.92335445
95NCOR_22424771_ChIP-Seq_293T_Human0.91622965
96AUTS2_25519132_ChIP-Seq_293T-REX_Human0.91513712
97KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.90458806
98HOXB7_26014856_ChIP-Seq_BT474_Human0.90083901
99XRN2_22483619_ChIP-Seq_HELA_Human0.89828956
100HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.89038019

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.15350172
2MP0008877_abnormal_DNA_methylation3.33203101
3MP0003693_abnormal_embryo_hatching2.75252524
4MP0003718_maternal_effect2.59881799
5MP0002102_abnormal_ear_morphology2.56131226
6MP0008058_abnormal_DNA_repair2.51465959
7MP0003890_abnormal_embryonic-extraembry2.48444293
8MP0010094_abnormal_chromosome_stability2.27398126
9MP0001293_anophthalmia2.25258122
10MP0006072_abnormal_retinal_apoptosis2.21677527
11MP0009379_abnormal_foot_pigmentation2.15846496
12MP0002938_white_spotting2.09031807
13MP0002254_reproductive_system_inflammat2.04150834
14MP0004133_heterotaxia2.03585051
15MP0004957_abnormal_blastocyst_morpholog2.01782254
16MP0008789_abnormal_olfactory_epithelium1.99195376
17MP0002736_abnormal_nociception_after1.95597509
18MP0003136_yellow_coat_color1.85051120
19MP0003119_abnormal_digestive_system1.77541617
20MP0003195_calcinosis1.75133869
21MP0010030_abnormal_orbit_morphology1.74457127
22MP0008872_abnormal_physiological_respon1.73855643
23MP0003567_abnormal_fetal_cardiomyocyte1.73466410
24MP0005551_abnormal_eye_electrophysiolog1.68494013
25MP0001968_abnormal_touch/_nociception1.66253391
26MP0008875_abnormal_xenobiotic_pharmacok1.63387585
27MP0003941_abnormal_skin_development1.55003010
28MP0003111_abnormal_nucleus_morphology1.54651271
29MP0008057_abnormal_DNA_replication1.54375091
30MP0003937_abnormal_limbs/digits/tail_de1.51599966
31MP0003806_abnormal_nucleotide_metabolis1.50305652
32MP0005394_taste/olfaction_phenotype1.48421288
33MP0005499_abnormal_olfactory_system1.48421288
34MP0002277_abnormal_respiratory_mucosa1.43691914
35MP0003646_muscle_fatigue1.43495876
36MP0002234_abnormal_pharynx_morphology1.40308048
37MP0000631_abnormal_neuroendocrine_gland1.40281078
38MP0000049_abnormal_middle_ear1.37465493
39MP0003077_abnormal_cell_cycle1.36486713
40MP0001485_abnormal_pinna_reflex1.36002415
41MP0001986_abnormal_taste_sensitivity1.31753715
42MP0003283_abnormal_digestive_organ1.31597590
43MP0000372_irregular_coat_pigmentation1.30078381
44MP0002837_dystrophic_cardiac_calcinosis1.29734738
45MP0002638_abnormal_pupillary_reflex1.24832698
46MP0008932_abnormal_embryonic_tissue1.20962939
47MP0005253_abnormal_eye_physiology1.20875227
48MP0002160_abnormal_reproductive_system1.20620664
49MP0002876_abnormal_thyroid_physiology1.20221100
50MP0009697_abnormal_copulation1.19934589
51MP0003786_premature_aging1.16964656
52MP0003011_delayed_dark_adaptation1.15703945
53MP0001286_abnormal_eye_development1.15531051
54MP0005377_hearing/vestibular/ear_phenot1.15266312
55MP0003878_abnormal_ear_physiology1.15266312
56MP0000516_abnormal_urinary_system1.14749794
57MP0005367_renal/urinary_system_phenotyp1.14749794
58MP0004147_increased_porphyrin_level1.14403826
59MP0002751_abnormal_autonomic_nervous1.13159621
60MP0005084_abnormal_gallbladder_morpholo1.12522708
61MP0005389_reproductive_system_phenotype1.12433793
62MP0003938_abnormal_ear_development1.11958624
63MP0000427_abnormal_hair_cycle1.11180380
64MP0002233_abnormal_nose_morphology1.11025319
65MP0004885_abnormal_endolymph1.08334377
66MP0005645_abnormal_hypothalamus_physiol1.05612337
67MP0001188_hyperpigmentation1.05053052
68MP0003186_abnormal_redox_activity1.04179233
69MP0001984_abnormal_olfaction1.01648960
70MP0008007_abnormal_cellular_replicative0.99973253
71MP0005646_abnormal_pituitary_gland0.97187274
72MP0003880_abnormal_central_pattern0.97007615
73MP0002210_abnormal_sex_determination0.95999869
74MP0001919_abnormal_reproductive_system0.94183080
75MP0001929_abnormal_gametogenesis0.90915597
76MP0006036_abnormal_mitochondrial_physio0.90217616
77MP0005410_abnormal_fertilization0.89852821
78MP0004142_abnormal_muscle_tone0.89841676
79MP0005075_abnormal_melanosome_morpholog0.89823984
80MP0000647_abnormal_sebaceous_gland0.87998991
81MP0002163_abnormal_gland_morphology0.87724292
82MP0008995_early_reproductive_senescence0.87109916
83MP0005195_abnormal_posterior_eye0.85395389
84MP0000653_abnormal_sex_gland0.83557717
85MP0001529_abnormal_vocalization0.80847087
86MP0001119_abnormal_female_reproductive0.80690258
87MP0009745_abnormal_behavioral_response0.79650078
88MP0001145_abnormal_male_reproductive0.79506445
89MP0002653_abnormal_ependyma_morphology0.79236239
90MP0004742_abnormal_vestibular_system0.76888592
91MP0002272_abnormal_nervous_system0.76852326
92MP0001324_abnormal_eye_pigmentation0.76726947
93MP0004145_abnormal_muscle_electrophysio0.76245322
94MP0003137_abnormal_impulse_conducting0.75379283
95MP0005391_vision/eye_phenotype0.75112673
96MP0004043_abnormal_pH_regulation0.74466531
97MP0002111_abnormal_tail_morphology0.73829689
98MP0004215_abnormal_myocardial_fiber0.73651161
99MP0003315_abnormal_perineum_morphology0.73482013
100MP0009046_muscle_twitch0.72092884

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.39156218
2Molar tooth sign on MRI (HP:0002419)3.14367948
3Abnormality of midbrain morphology (HP:0002418)3.14367948
4Septo-optic dysplasia (HP:0100842)2.94259626
5Colon cancer (HP:0003003)2.92067852
6Lipid accumulation in hepatocytes (HP:0006561)2.90902844
7Abnormal number of erythroid precursors (HP:0012131)2.90697340
8Increased hepatocellular lipid droplets (HP:0006565)2.89504527
9Abnormality of the labia minora (HP:0012880)2.88976169
10Methylmalonic acidemia (HP:0002912)2.84156191
11Acute necrotizing encephalopathy (HP:0006965)2.79082143
12Abnormality of cells of the erythroid lineage (HP:0012130)2.77367196
13Nephronophthisis (HP:0000090)2.76061482
14Pancreatic fibrosis (HP:0100732)2.71654509
15Mitochondrial inheritance (HP:0001427)2.69725351
16Abnormality of alanine metabolism (HP:0010916)2.66936195
17Hyperalaninemia (HP:0003348)2.66936195
18Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.66936195
19Acute encephalopathy (HP:0006846)2.64066695
20Increased CSF lactate (HP:0002490)2.62812309
21True hermaphroditism (HP:0010459)2.57926075
22Bilateral microphthalmos (HP:0007633)2.55972538
23Meckel diverticulum (HP:0002245)2.53702487
24Congenital, generalized hypertrichosis (HP:0004540)2.53077417
253-Methylglutaconic aciduria (HP:0003535)2.50518932
26Abnormality of the ileum (HP:0001549)2.49029663
27Macrocytic anemia (HP:0001972)2.45511032
28Stenosis of the external auditory canal (HP:0000402)2.45418429
29Reticulocytopenia (HP:0001896)2.40540496
30Methylmalonic aciduria (HP:0012120)2.39089157
31Aplasia/Hypoplasia of the uvula (HP:0010293)2.37342849
32Abnormality of serum amino acid levels (HP:0003112)2.34243276
33Hyperglycinemia (HP:0002154)2.28058814
34Abnormal mitochondria in muscle tissue (HP:0008316)2.27331619
35Abnormality of the renal medulla (HP:0100957)2.26273158
36Congenital stationary night blindness (HP:0007642)2.24429178
37Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.22610481
38Abnormality of chromosome stability (HP:0003220)2.21906374
39Progressive macrocephaly (HP:0004481)2.21465489
40Abnormality of aspartate family amino acid metabolism (HP:0010899)2.17376618
41Pendular nystagmus (HP:0012043)2.16921102
42Hyperglycinuria (HP:0003108)2.16637500
43Abolished electroretinogram (ERG) (HP:0000550)2.15226643
44Abnormality of the renal cortex (HP:0011035)2.14406236
45Absent thumb (HP:0009777)2.11537655
46Abnormality of the pons (HP:0007361)2.10975786
47Hepatocellular necrosis (HP:0001404)2.08757815
48Anophthalmia (HP:0000528)2.08028633
49Birth length less than 3rd percentile (HP:0003561)2.05474664
50Triphalangeal thumb (HP:0001199)2.05102792
51Renal Fanconi syndrome (HP:0001994)2.04744359
52Increased serum lactate (HP:0002151)2.03847180
53Chromsome breakage (HP:0040012)2.03788888
54Hypoplasia of the pons (HP:0012110)2.00280578
55Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.99093097
56Decreased activity of mitochondrial respiratory chain (HP:0008972)1.99093097
57Optic nerve hypoplasia (HP:0000609)1.98956793
58IgG deficiency (HP:0004315)1.98024901
59Abnormality of serine family amino acid metabolism (HP:0010894)1.97742504
60Abnormality of glycine metabolism (HP:0010895)1.97742504
61Intestinal atresia (HP:0011100)1.97510475
62Chronic hepatic failure (HP:0100626)1.97275357
63Tubular atrophy (HP:0000092)1.96644359
64Chromosomal breakage induced by crosslinking agents (HP:0003221)1.95928580
65Medial flaring of the eyebrow (HP:0010747)1.94424342
66Abnormality of the preputium (HP:0100587)1.93914370
67Horseshoe kidney (HP:0000085)1.93388824
68Absent septum pellucidum (HP:0001331)1.91022165
69Cleft eyelid (HP:0000625)1.88367817
70Oligodactyly (hands) (HP:0001180)1.87770117
71Maternal diabetes (HP:0009800)1.86817374
72Hepatic necrosis (HP:0002605)1.86463845
73Sclerocornea (HP:0000647)1.85512106
74Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.84974559
75Abnormality of methionine metabolism (HP:0010901)1.84357714
76Abnormal lung lobation (HP:0002101)1.83850629
77Patellar aplasia (HP:0006443)1.83784180
78Absent radius (HP:0003974)1.83585856
79Exertional dyspnea (HP:0002875)1.82789368
80Aplasia/hypoplasia of the uterus (HP:0008684)1.82472061
81Absent forearm bone (HP:0003953)1.82265798
82Aplasia involving forearm bones (HP:0009822)1.82265798
83Anencephaly (HP:0002323)1.81535338
84Aplasia/Hypoplasia of the patella (HP:0006498)1.80944452
85Ectopic kidney (HP:0000086)1.80821171
86Abnormality of abdominal situs (HP:0011620)1.80744915
87Abdominal situs inversus (HP:0003363)1.80744915
88Aplasia/Hypoplasia of the spleen (HP:0010451)1.79978451
89Type I transferrin isoform profile (HP:0003642)1.79075458
90Supernumerary spleens (HP:0009799)1.77045807
91Pallor (HP:0000980)1.76679281
92Abnormality of the duodenum (HP:0002246)1.76412998
93Abnormality of homocysteine metabolism (HP:0010919)1.76259325
94Homocystinuria (HP:0002156)1.76259325
95Progressive inability to walk (HP:0002505)1.75721883
96Duodenal stenosis (HP:0100867)1.75397572
97Small intestinal stenosis (HP:0012848)1.75397572
98Clubbing of toes (HP:0100760)1.74780844
99Lactic acidosis (HP:0003128)1.74698791
100Cerebral edema (HP:0002181)1.74588660

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.27238357
2TLK13.25849501
3NUAK13.20329247
4VRK22.73040643
5BMPR1B2.60321793
6BUB12.57357213
7WNK32.51220227
8CDC72.31490003
9STK162.30955565
10MKNK22.25202185
11ADRBK22.22124354
12GRK12.14217251
13PLK42.14087509
14ACVR1B2.12839416
15MAP4K22.10346216
16FRK2.07043050
17VRK12.03062378
18TNIK2.01087419
19MST41.89621237
20SRPK11.79333581
21PLK31.71372718
22MKNK11.71340765
23WNK41.69209844
24OXSR11.62711936
25INSRR1.49782181
26BRSK21.49717554
27TTK1.49645162
28TSSK61.46763657
29CDK191.46524666
30WEE11.42699023
31TRIM281.39253726
32PBK1.33989926
33NME11.33068732
34TAF11.27426864
35STK391.23639538
36PLK11.18849712
37DYRK21.16257897
38TXK1.14583962
39PASK1.06421658
40EIF2AK31.06268479
41TGFBR11.03356934
42MAPK131.02372819
43PNCK1.00606511
44PINK10.98124701
45STK38L0.95939575
46TIE10.94044393
47TAOK30.92322437
48ERBB40.89660473
49BCKDK0.89031537
50CHEK20.86831426
51ATR0.86238625
52NEK20.79829559
53MAP3K40.78977624
54NEK10.78591727
55CSNK1G10.75789583
56AURKB0.75651814
57STK30.75456606
58MAP2K20.71636867
59EIF2AK20.68569233
60PRKCG0.65452966
61RPS6KA50.64919357
62TEC0.64001698
63PRKCE0.63966866
64PDK20.63346231
65ATM0.62401174
66PLK20.58234597
67CASK0.58151084
68CSNK1G20.57969475
69WNK10.55839483
70ADRBK10.55553227
71EIF2AK10.54858766
72FLT30.54485312
73CSNK1G30.53451348
74CSNK2A10.51478501
75PRKCI0.51137676
76RPS6KB20.48768113
77PAK30.47309321
78CSNK2A20.46524111
79CHEK10.46283670
80PHKG10.44804575
81PHKG20.44804575
82CSNK1A10.43067688
83FGFR20.43000195
84FGFR10.42650999
85CSNK1E0.41799761
86MAP3K120.40450823
87PKN10.38729083
88NLK0.38093375
89CDK30.37899786
90OBSCN0.37899439
91DYRK30.36668384
92CSNK1A1L0.36316450
93MAPKAPK50.36141090
94IKBKB0.35515811
95DAPK20.35113547
96CDK80.35095743
97BCR0.34887670
98CDK10.34108930
99PIM10.33513336
100CSNK1D0.33063438

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.01453677
2Oxidative phosphorylation_Homo sapiens_hsa001903.17063094
3Homologous recombination_Homo sapiens_hsa034402.83492988
4Protein export_Homo sapiens_hsa030602.70109753
5RNA polymerase_Homo sapiens_hsa030202.64446562
6Proteasome_Homo sapiens_hsa030502.63824518
7Parkinsons disease_Homo sapiens_hsa050122.55906740
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.43818808
9Mismatch repair_Homo sapiens_hsa034302.42386928
10Basal transcription factors_Homo sapiens_hsa030222.38089524
11DNA replication_Homo sapiens_hsa030302.19983282
12RNA degradation_Homo sapiens_hsa030181.98522263
13One carbon pool by folate_Homo sapiens_hsa006701.96784629
14Fanconi anemia pathway_Homo sapiens_hsa034601.93430680
15Selenocompound metabolism_Homo sapiens_hsa004501.91520256
16Nucleotide excision repair_Homo sapiens_hsa034201.89697408
17Huntingtons disease_Homo sapiens_hsa050161.89560146
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.74353437
19Non-homologous end-joining_Homo sapiens_hsa034501.68142369
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.67907230
21Spliceosome_Homo sapiens_hsa030401.63708422
22RNA transport_Homo sapiens_hsa030131.59664624
23Alzheimers disease_Homo sapiens_hsa050101.57516081
24Linoleic acid metabolism_Homo sapiens_hsa005911.51340713
25Phototransduction_Homo sapiens_hsa047441.47973072
26Base excision repair_Homo sapiens_hsa034101.45797531
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43803584
28Caffeine metabolism_Homo sapiens_hsa002321.42864944
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.35245493
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.33977520
31Propanoate metabolism_Homo sapiens_hsa006401.33847102
32Pyrimidine metabolism_Homo sapiens_hsa002401.29064127
33Cardiac muscle contraction_Homo sapiens_hsa042601.25504353
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.25495265
35Nitrogen metabolism_Homo sapiens_hsa009101.25318071
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.22823044
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20883118
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17170938
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.15005887
40Vitamin digestion and absorption_Homo sapiens_hsa049771.11083105
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09722024
42Tryptophan metabolism_Homo sapiens_hsa003801.08648441
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08189956
44Purine metabolism_Homo sapiens_hsa002301.05654410
45Chemical carcinogenesis_Homo sapiens_hsa052041.02836519
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02711001
47Pentose and glucuronate interconversions_Homo sapiens_hsa000400.99996203
48Asthma_Homo sapiens_hsa053100.98051934
49Intestinal immune network for IgA production_Homo sapiens_hsa046720.97465808
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95786544
51Ether lipid metabolism_Homo sapiens_hsa005650.95030632
52Retinol metabolism_Homo sapiens_hsa008300.93807443
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.91632167
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90731276
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89910896
56Butanoate metabolism_Homo sapiens_hsa006500.88936010
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84961014
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81600375
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80520920
60Steroid biosynthesis_Homo sapiens_hsa001000.77646563
61Nicotine addiction_Homo sapiens_hsa050330.77163771
62Cell cycle_Homo sapiens_hsa041100.75279921
63Peroxisome_Homo sapiens_hsa041460.74717233
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.74119912
65Folate biosynthesis_Homo sapiens_hsa007900.73866801
66Regulation of autophagy_Homo sapiens_hsa041400.73101361
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72026517
68Arachidonic acid metabolism_Homo sapiens_hsa005900.71822574
69Metabolic pathways_Homo sapiens_hsa011000.71073544
70Fat digestion and absorption_Homo sapiens_hsa049750.67760592
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.67048349
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.66031362
73Glutathione metabolism_Homo sapiens_hsa004800.60147616
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58484280
75Collecting duct acid secretion_Homo sapiens_hsa049660.56834144
76Olfactory transduction_Homo sapiens_hsa047400.55188978
77Pyruvate metabolism_Homo sapiens_hsa006200.54795579
78p53 signaling pathway_Homo sapiens_hsa041150.53934375
79beta-Alanine metabolism_Homo sapiens_hsa004100.53921123
80Sulfur metabolism_Homo sapiens_hsa009200.53109841
81Systemic lupus erythematosus_Homo sapiens_hsa053220.53091827
82Autoimmune thyroid disease_Homo sapiens_hsa053200.52602958
83Sulfur relay system_Homo sapiens_hsa041220.51400896
84Primary immunodeficiency_Homo sapiens_hsa053400.51295787
85Graft-versus-host disease_Homo sapiens_hsa053320.51235952
86Taste transduction_Homo sapiens_hsa047420.50894530
87Allograft rejection_Homo sapiens_hsa053300.50047047
88mRNA surveillance pathway_Homo sapiens_hsa030150.46316827
89Type I diabetes mellitus_Homo sapiens_hsa049400.43565839
90Fatty acid elongation_Homo sapiens_hsa000620.43350221
91Fatty acid degradation_Homo sapiens_hsa000710.36445952
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34888541
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33230816
94Basal cell carcinoma_Homo sapiens_hsa052170.32102643
95Hedgehog signaling pathway_Homo sapiens_hsa043400.31844128
96Vitamin B6 metabolism_Homo sapiens_hsa007500.31708635
97TGF-beta signaling pathway_Homo sapiens_hsa043500.31425659
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30403914
99Mineral absorption_Homo sapiens_hsa049780.28826987
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27408954

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