ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	6.68723307
2	behavioral response to nicotine (GO:0035095)	5.48263326
3	L-fucose catabolic process (GO:0042355)	4.24275323
4	fucose catabolic process (GO:0019317)	4.24275323
5	L-fucose metabolic process (GO:0042354)	4.24275323
6	DNA deamination (GO:0045006)	3.75784535
7	epithelial cilium movement (GO:0003351)	3.71582392
8	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.69991211
9	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.69991211
10	indolalkylamine metabolic process (GO:0006586)	3.59456230
11	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.56181263
12	piRNA metabolic process (GO:0034587)	3.56160992
13	platelet dense granule organization (GO:0060155)	3.44520193
14	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.35466416
15	protein-cofactor linkage (GO:0018065)	3.33129179
16	DNA double-strand break processing (GO:0000729)	3.30867931
17	retinal cone cell development (GO:0046549)	3.30026187
18	neural tube formation (GO:0001841)	3.25774995
19	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.23224782
20	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.23224782
21	preassembly of GPI anchor in ER membrane (GO:0016254)	3.20589727
22	DNA integration (GO:0015074)	3.17777691
23	protein polyglutamylation (GO:0018095)	3.15737013
24	regulation of cilium movement (GO:0003352)	3.11705529
25	cornea development in camera-type eye (GO:0061303)	3.06172273
26	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.04634295
27	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.03997544
28	glycosphingolipid biosynthetic process (GO:0006688)	3.02762614
29	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.00886402
30	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.00886402
31	NADH dehydrogenase complex assembly (GO:0010257)	3.00886402
32	replication fork processing (GO:0031297)	2.99732279
33	negative regulation of telomere maintenance (GO:0032205)	2.91748269
34	axoneme assembly (GO:0035082)	2.91524705
35	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.89770587
36	regulation of telomere maintenance (GO:0032204)	2.89461827
37	DNA methylation involved in gamete generation (GO:0043046)	2.88950476
38	activated T cell proliferation (GO:0050798)	2.88611647
39	GPI anchor metabolic process (GO:0006505)	2.88329637
40	protein K11-linked deubiquitination (GO:0035871)	2.86508476
41	nonmotile primary cilium assembly (GO:0035058)	2.85955787
42	gamma-aminobutyric acid transport (GO:0015812)	2.84498658
43	mannosylation (GO:0097502)	2.84103607
44	cilium movement (GO:0003341)	2.83197450
45	L-methionine salvage (GO:0071267)	2.79299507
46	L-methionine biosynthetic process (GO:0071265)	2.79299507
47	amino acid salvage (GO:0043102)	2.79299507
48	cilium morphogenesis (GO:0060271)	2.79202865
49	behavioral response to ethanol (GO:0048149)	2.78118034
50	indole-containing compound metabolic process (GO:0042430)	2.76399369
51	pyrimidine nucleobase catabolic process (GO:0006208)	2.76024813
52	water-soluble vitamin biosynthetic process (GO:0042364)	2.72044676
53	respiratory chain complex IV assembly (GO:0008535)	2.71324724
54	primary amino compound metabolic process (GO:1901160)	2.71258681
55	protein complex biogenesis (GO:0070271)	2.71253586
56	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.69895656
57	detection of light stimulus involved in visual perception (GO:0050908)	2.69269450
58	detection of light stimulus involved in sensory perception (GO:0050962)	2.69269450
59	tryptophan metabolic process (GO:0006568)	2.68581998
60	nucleobase catabolic process (GO:0046113)	2.65020479
61	photoreceptor cell development (GO:0042461)	2.64889315
62	kynurenine metabolic process (GO:0070189)	2.64448579
63	cilium organization (GO:0044782)	2.62840096
64	recombinational repair (GO:0000725)	2.62805256
65	regulation of glucokinase activity (GO:0033131)	2.61789437
66	regulation of hexokinase activity (GO:1903299)	2.61789437
67	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.60939021
68	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.60939021
69	regulation of translation, ncRNA-mediated (GO:0045974)	2.60939021
70	double-strand break repair via homologous recombination (GO:0000724)	2.60486683
71	indole-containing compound catabolic process (GO:0042436)	2.59907973
72	indolalkylamine catabolic process (GO:0046218)	2.59907973
73	tryptophan catabolic process (GO:0006569)	2.59907973
74	kidney morphogenesis (GO:0060993)	2.59610021
75	photoreceptor cell maintenance (GO:0045494)	2.58362221
76	neuronal action potential (GO:0019228)	2.58221630
77	cilium assembly (GO:0042384)	2.56622208
78	regulation of microtubule-based movement (GO:0060632)	2.51987897
79	reflex (GO:0060004)	2.49479684
80	mitochondrial respiratory chain complex assembly (GO:0033108)	2.48570095
81	histone H3-K9 methylation (GO:0051567)	2.47566162
82	cell differentiation in spinal cord (GO:0021515)	2.47389083
83	centriole replication (GO:0007099)	2.47335845
84	reciprocal DNA recombination (GO:0035825)	2.47056806
85	reciprocal meiotic recombination (GO:0007131)	2.47056806
86	male meiosis I (GO:0007141)	2.46410915
87	serotonin metabolic process (GO:0042428)	2.45839853
88	resolution of meiotic recombination intermediates (GO:0000712)	2.43633099
89	anterograde synaptic vesicle transport (GO:0048490)	2.43149544
90	neuron fate specification (GO:0048665)	2.42580708
91	intraciliary transport (GO:0042073)	2.41190917
92	fucosylation (GO:0036065)	2.40672810
93	spinal cord development (GO:0021510)	2.40531615
94	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.39574194
95	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.39258873
96	glycolipid biosynthetic process (GO:0009247)	2.38335944
97	protein localization to cilium (GO:0061512)	2.35980690
98	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.33523556
99	embryonic epithelial tube formation (GO:0001838)	2.33293234
100	spinal cord motor neuron differentiation (GO:0021522)	2.33262412

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.86960831
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.18752251
3	VDR_22108803_ChIP-Seq_LS180_Human	3.13135723
4	EZH2_22144423_ChIP-Seq_EOC_Human	2.91933325
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.66643032
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.64734669
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.64624820
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.56711402
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.55592488
10	EWS_26573619_Chip-Seq_HEK293_Human	2.41662268
11	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.35713011
12	IRF1_19129219_ChIP-ChIP_H3396_Human	2.26568283
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.21638115
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.19444593
15	FUS_26573619_Chip-Seq_HEK293_Human	2.15817499
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.02444320
17	TAF15_26573619_Chip-Seq_HEK293_Human	1.99948088
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.97659073
19	P300_19829295_ChIP-Seq_ESCs_Human	1.95122195
20	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.93315587
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.89891902
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.83237544
23	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.80652210
24	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.78833835
25	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.77075672
26	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.77075672
27	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.75871485
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.74162897
29	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.72835832
30	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.72659648
31	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.71429064
32	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.69951964
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.60389154
34	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.57815962
35	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.54963139
36	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.54131764
37	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.53936493
38	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.50793280
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.50726912
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.50726912
41	SMAD4_21799915_ChIP-Seq_A2780_Human	1.47229793
42	STAT3_23295773_ChIP-Seq_U87_Human	1.46291484
43	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.45707027
44	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.43099417
45	TP53_22573176_ChIP-Seq_HFKS_Human	1.42959751
46	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.41126886
47	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.40000948
48	TCF4_23295773_ChIP-Seq_U87_Human	1.38961173
49	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.38896332
50	ELK1_19687146_ChIP-ChIP_HELA_Human	1.38332499
51	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.37910671
52	MYC_18940864_ChIP-ChIP_HL60_Human	1.37326247
53	AR_25329375_ChIP-Seq_VCAP_Human	1.37222874
54	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.37008475
55	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.36632836
56	BCAT_22108803_ChIP-Seq_LS180_Human	1.34161578
57	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.32754568
58	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.32569992
59	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.32338313
60	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.29856392
61	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.29769899
62	TCF4_22108803_ChIP-Seq_LS180_Human	1.28722456
63	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.27811750
64	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.26720462
65	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24919213
66	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.22102966
67	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.22102186
68	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.20411283
69	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.20006164
70	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.19988156
71	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.19375180
72	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.18064848
73	REST_21632747_ChIP-Seq_MESCs_Mouse	1.17820240
74	AR_21572438_ChIP-Seq_LNCaP_Human	1.17794783
75	RUNX2_22187159_ChIP-Seq_PCA_Human	1.17422097
76	RNF2_27304074_Chip-Seq_NSC_Mouse	1.17174852
77	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.16982430
78	P53_22387025_ChIP-Seq_ESCs_Mouse	1.16554613
79	NANOG_19829295_ChIP-Seq_ESCs_Human	1.15741628
80	SOX2_19829295_ChIP-Seq_ESCs_Human	1.15741628
81	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.14320419
82	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.13945819
83	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.12582919
84	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.12505638
85	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.12505638
86	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.11882021
87	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.09208781
88	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.07678943
89	VDR_23849224_ChIP-Seq_CD4+_Human	1.07246193
90	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.06990399
91	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.05224594
92	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.04104878
93	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.03271517
94	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01381859
95	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.01323634
96	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.99280507
97	CDX2_22108803_ChIP-Seq_LS180_Human	0.98866946
98	P300_18555785_Chip-Seq_ESCs_Mouse	0.98798914
99	NCOR_22424771_ChIP-Seq_293T_Human	0.98300111
100	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.96172201

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.08365184
2	MP0002653_abnormal_ependyma_morphology	2.66658628
3	MP0003787_abnormal_imprinting	2.56537182
4	MP0002102_abnormal_ear_morphology	2.45119119
5	MP0003880_abnormal_central_pattern	2.44838990
6	MP0006072_abnormal_retinal_apoptosis	2.38353912
7	MP0003136_yellow_coat_color	2.37797620
8	MP0003195_calcinosis	2.22781170
9	MP0006292_abnormal_olfactory_placode	2.19667922
10	MP0002638_abnormal_pupillary_reflex	2.18869376
11	MP0005551_abnormal_eye_electrophysiolog	2.14931785
12	MP0001968_abnormal_touch/_nociception	2.13599253
13	MP0005253_abnormal_eye_physiology	2.08852508
14	MP0000427_abnormal_hair_cycle	1.91984041
15	MP0009745_abnormal_behavioral_response	1.84944305
16	MP0002736_abnormal_nociception_after	1.84023682
17	MP0002837_dystrophic_cardiac_calcinosis	1.81455317
18	MP0004133_heterotaxia	1.72317728
19	MP0008789_abnormal_olfactory_epithelium	1.72254732
20	MP0008058_abnormal_DNA_repair	1.71304688
21	MP0008872_abnormal_physiological_respon	1.69893226
22	MP0003283_abnormal_digestive_organ	1.66924432
23	MP0002938_white_spotting	1.65560102
24	MP0000569_abnormal_digit_pigmentation	1.64724261
25	MP0005646_abnormal_pituitary_gland	1.64260276
26	MP0002272_abnormal_nervous_system	1.61926164
27	MP0005645_abnormal_hypothalamus_physiol	1.60976753
28	MP0001485_abnormal_pinna_reflex	1.58753049
29	MP0006276_abnormal_autonomic_nervous	1.57512990
30	MP0000631_abnormal_neuroendocrine_gland	1.56925823
31	MP0009046_muscle_twitch	1.56813879
32	MP0008995_early_reproductive_senescence	1.51401678
33	MP0003890_abnormal_embryonic-extraembry	1.51343252
34	MP0004885_abnormal_endolymph	1.51008527
35	MP0002751_abnormal_autonomic_nervous	1.50272629
36	MP0000778_abnormal_nervous_system	1.43605747
37	MP0010386_abnormal_urinary_bladder	1.43478906
38	MP0005499_abnormal_olfactory_system	1.41068262
39	MP0005394_taste/olfaction_phenotype	1.41068262
40	MP0004145_abnormal_muscle_electrophysio	1.40947110
41	MP0001986_abnormal_taste_sensitivity	1.38694449
42	MP0002064_seizures	1.38643361
43	MP0008875_abnormal_xenobiotic_pharmacok	1.38021104
44	MP0004142_abnormal_muscle_tone	1.37464378
45	MP0003119_abnormal_digestive_system	1.36127956
46	MP0000372_irregular_coat_pigmentation	1.35566739
47	MP0005379_endocrine/exocrine_gland_phen	1.34308690
48	MP0004043_abnormal_pH_regulation	1.32329830
49	MP0003121_genomic_imprinting	1.30254699
50	MP0001486_abnormal_startle_reflex	1.28754738
51	MP0002876_abnormal_thyroid_physiology	1.27874979
52	MP0002067_abnormal_sensory_capabilities	1.27448184
53	MP0002572_abnormal_emotion/affect_behav	1.26299140
54	MP0002163_abnormal_gland_morphology	1.25448757
55	MP0005084_abnormal_gallbladder_morpholo	1.24260851
56	MP0002928_abnormal_bile_duct	1.24115517
57	MP0004147_increased_porphyrin_level	1.21771510
58	MP0004742_abnormal_vestibular_system	1.17354890
59	MP0005171_absent_coat_pigmentation	1.15654730
60	MP0005187_abnormal_penis_morphology	1.15352959
61	MP0001529_abnormal_vocalization	1.14793652
62	MP0000383_abnormal_hair_follicle	1.14571127
63	MP0000647_abnormal_sebaceous_gland	1.14319965
64	MP0005195_abnormal_posterior_eye	1.12860079
65	MP0002557_abnormal_social/conspecific_i	1.11083784
66	MP0002095_abnormal_skin_pigmentation	1.09814762
67	MP0003011_delayed_dark_adaptation	1.09272826
68	MP0005174_abnormal_tail_pigmentation	1.07807786
69	MP0002277_abnormal_respiratory_mucosa	1.06211716
70	MP0001984_abnormal_olfaction	1.05210822
71	MP0001501_abnormal_sleep_pattern	1.04940738
72	MP0003635_abnormal_synaptic_transmissio	1.03466083
73	MP0001970_abnormal_pain_threshold	1.03158079
74	MP0002752_abnormal_somatic_nervous	1.01675962
75	MP0003786_premature_aging	1.00517061
76	MP0002063_abnormal_learning/memory/cond	0.99686949
77	MP0002234_abnormal_pharynx_morphology	0.98894634
78	MP0002184_abnormal_innervation	0.98330192
79	MP0005389_reproductive_system_phenotype	0.97265600
80	MP0003718_maternal_effect	0.96454383
81	MP0002160_abnormal_reproductive_system	0.96307342
82	MP0002210_abnormal_sex_determination	0.96074584
83	MP0001293_anophthalmia	0.93684061
84	MP0005391_vision/eye_phenotype	0.92984713
85	MP0008057_abnormal_DNA_replication	0.91617767
86	MP0002733_abnormal_thermal_nociception	0.91405051
87	MP0002735_abnormal_chemical_nociception	0.88734193
88	MP0003698_abnormal_male_reproductive	0.88019915
89	MP0001929_abnormal_gametogenesis	0.87291829
90	MP0001963_abnormal_hearing_physiology	0.86594837
91	MP0005386_behavior/neurological_phenoty	0.85872163
92	MP0004924_abnormal_behavior	0.85872163
93	MP0001919_abnormal_reproductive_system	0.84689242
94	MP0002254_reproductive_system_inflammat	0.83188307
95	MP0003567_abnormal_fetal_cardiomyocyte	0.83181770
96	MP0000955_abnormal_spinal_cord	0.82313226
97	MP0005075_abnormal_melanosome_morpholog	0.81302083
98	MP0002882_abnormal_neuron_morphology	0.81130081
99	MP0003937_abnormal_limbs/digits/tail_de	0.80369140
100	MP0000653_abnormal_sex_gland	0.79785938

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.28808894
2	Pancreatic fibrosis (HP:0100732)	3.93910629
3	Molar tooth sign on MRI (HP:0002419)	3.85563797
4	Abnormality of midbrain morphology (HP:0002418)	3.85563797
5	True hermaphroditism (HP:0010459)	3.81029879
6	Nephronophthisis (HP:0000090)	3.62199284
7	Congenital stationary night blindness (HP:0007642)	3.50257361
8	Hyperventilation (HP:0002883)	3.31259546
9	Abnormal biliary tract physiology (HP:0012439)	3.21866628
10	Bile duct proliferation (HP:0001408)	3.21866628
11	Abnormality of the renal medulla (HP:0100957)	3.21024484
12	Abnormality of the renal cortex (HP:0011035)	3.09681389
13	Abnormality of alanine metabolism (HP:0010916)	2.95585528
14	Hyperalaninemia (HP:0003348)	2.95585528
15	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.95585528
16	Medial flaring of the eyebrow (HP:0010747)	2.74834586
17	Abolished electroretinogram (ERG) (HP:0000550)	2.74492136
18	Type II lissencephaly (HP:0007260)	2.74467031
19	Renal cortical cysts (HP:0000803)	2.64370938
20	Febrile seizures (HP:0002373)	2.56018542
21	Cystic liver disease (HP:0006706)	2.48849034
22	Chronic hepatic failure (HP:0100626)	2.46969197
23	Progressive inability to walk (HP:0002505)	2.46789645
24	Intestinal atresia (HP:0011100)	2.43652866
25	Tubular atrophy (HP:0000092)	2.38242954
26	Inability to walk (HP:0002540)	2.37294703
27	Attenuation of retinal blood vessels (HP:0007843)	2.32922670
28	Lissencephaly (HP:0001339)	2.29943054
29	3-Methylglutaconic aciduria (HP:0003535)	2.27757839
30	Gait imbalance (HP:0002141)	2.24898607
31	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.23612234
32	Methylmalonic acidemia (HP:0002912)	2.22790741
33	Hypothermia (HP:0002045)	2.20821991
34	Sclerocornea (HP:0000647)	2.18258808
35	Abnormal rod and cone electroretinograms (HP:0008323)	2.16519688
36	Rhinitis (HP:0012384)	2.15668061
37	Pendular nystagmus (HP:0012043)	2.14477684
38	Gaze-evoked nystagmus (HP:0000640)	2.12758898
39	Cerebellar dysplasia (HP:0007033)	2.12152736
40	Congenital primary aphakia (HP:0007707)	2.11886921
41	Postaxial foot polydactyly (HP:0001830)	2.09608510
42	Polydipsia (HP:0001959)	2.08519734
43	Abnormal drinking behavior (HP:0030082)	2.08519734
44	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.07956224
45	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.02996079
46	Absent speech (HP:0001344)	2.01799970
47	Decreased circulating renin level (HP:0003351)	2.01031520
48	Nephrogenic diabetes insipidus (HP:0009806)	2.00930550
49	Polyuria (HP:0000103)	1.98325725
50	Male pseudohermaphroditism (HP:0000037)	1.97956617
51	Pachygyria (HP:0001302)	1.97739109
52	Oligodactyly (hands) (HP:0001180)	1.96441942
53	Anencephaly (HP:0002323)	1.96330127
54	Asplenia (HP:0001746)	1.93602425
55	Short tibia (HP:0005736)	1.93217112
56	Genital tract atresia (HP:0001827)	1.92575921
57	Abnormality of the labia minora (HP:0012880)	1.92206553
58	Increased corneal curvature (HP:0100692)	1.91865766
59	Keratoconus (HP:0000563)	1.91865766
60	Atonic seizures (HP:0010819)	1.91242588
61	Methylmalonic aciduria (HP:0012120)	1.89984153
62	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.87674557
63	Colon cancer (HP:0003003)	1.86794593
64	Chorioretinal atrophy (HP:0000533)	1.86544051
65	Severe muscular hypotonia (HP:0006829)	1.86229120
66	Fair hair (HP:0002286)	1.85995085
67	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.85824933
68	Dandy-Walker malformation (HP:0001305)	1.85354756
69	Hypoplasia of the pons (HP:0012110)	1.83595700
70	Preaxial hand polydactyly (HP:0001177)	1.82493968
71	Patellar aplasia (HP:0006443)	1.81769753
72	Vaginal atresia (HP:0000148)	1.80117233
73	Hyperglycinemia (HP:0002154)	1.79786014
74	Optic nerve hypoplasia (HP:0000609)	1.78131767
75	Congenital hepatic fibrosis (HP:0002612)	1.78115236
76	Abnormality of the ileum (HP:0001549)	1.76039002
77	Postaxial hand polydactyly (HP:0001162)	1.75607062
78	Hypomagnesemia (HP:0002917)	1.75343802
79	Bony spicule pigmentary retinopathy (HP:0007737)	1.75202244
80	Furrowed tongue (HP:0000221)	1.74790076
81	Aplasia/hypoplasia of the uterus (HP:0008684)	1.74687073
82	Progressive cerebellar ataxia (HP:0002073)	1.74627119
83	Aplasia/Hypoplasia of the patella (HP:0006498)	1.74602963
84	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.73217526
85	Optic disc pallor (HP:0000543)	1.71232702
86	Thyroid-stimulating hormone excess (HP:0002925)	1.70292791
87	Widely spaced teeth (HP:0000687)	1.68340562
88	Meckel diverticulum (HP:0002245)	1.66705916
89	Narrow forehead (HP:0000341)	1.66678132
90	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.66069628
91	Tubulointerstitial abnormality (HP:0001969)	1.65986915
92	Poor coordination (HP:0002370)	1.65864121
93	Increased CSF lactate (HP:0002490)	1.65050423
94	Broad-based gait (HP:0002136)	1.64335424
95	Anophthalmia (HP:0000528)	1.63711795
96	Abnormality of the pons (HP:0007361)	1.62887833
97	Aganglionic megacolon (HP:0002251)	1.61307187
98	Genetic anticipation (HP:0003743)	1.60534753
99	Tubulointerstitial nephritis (HP:0001970)	1.60427458
100	Drooling (HP:0002307)	1.60035036

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.45063664
2	WNK3	3.42893068
3	TRIM28	2.98019942
4	ADRBK2	2.96501324
5	NUAK1	2.71043549
6	ACVR1B	2.65238338
7	MAP3K4	2.63931802
8	BMPR1B	2.55579924
9	CASK	2.37378848
10	MAP4K2	2.17730898
11	GRK1	2.05209499
12	PINK1	1.98176672
13	MAP2K7	1.97904421
14	ZAK	1.96723471
15	MAPK13	1.93068583
16	MARK1	1.91141835
17	WNK4	1.87651608
18	TXK	1.71798805
19	BCR	1.71727257
20	STK39	1.68405577
21	TAOK3	1.58682782
22	OXSR1	1.55650370
23	DYRK2	1.43180313
24	MKNK2	1.33355919
25	VRK1	1.30161742
26	PAK3	1.29170970
27	TNIK	1.27011450
28	MUSK	1.24138966
29	PRKCE	1.21345962
30	PHKG2	1.20007277
31	PHKG1	1.20007277
32	TLK1	1.14465562
33	INSRR	1.13824476
34	PNCK	1.07361313
35	DAPK2	1.05907621
36	WEE1	1.04884946
37	PIK3CA	0.97841660
38	CSNK1G2	0.97635693
39	TGFBR1	0.96829035
40	MAP2K6	0.94347047
41	AKT3	0.94122091
42	ADRBK1	0.93593336
43	MAP2K4	0.92622761
44	PRKCG	0.92174184
45	CSNK1G1	0.91162935
46	ERBB3	0.89540232
47	PLK2	0.89474666
48	STK38L	0.87789715
49	CDK3	0.85988863
50	CSNK1G3	0.83315676
51	MAPK7	0.80737313
52	PLK4	0.80619330
53	CAMKK2	0.79783736
54	MKNK1	0.79593548
55	BMPR2	0.78547199
56	DYRK3	0.76480511
57	PRKCQ	0.76366045
58	MST4	0.76295293
59	NTRK3	0.75973501
60	CSNK1A1L	0.73268038
61	VRK2	0.72252812
62	DYRK1A	0.67977651
63	BCKDK	0.66657619
64	EPHA4	0.65134278
65	CAMK2A	0.62256494
66	EPHA3	0.60031929
67	CHEK2	0.58931993
68	PRKG1	0.57300129
69	PLK3	0.56531967
70	STK3	0.55177068
71	FLT3	0.55099174
72	ERBB2	0.55022237
73	SGK2	0.52428032
74	PRKACA	0.48651406
75	TEC	0.48052186
76	ATR	0.46902256
77	CAMK4	0.46312398
78	PASK	0.46279106
79	MINK1	0.46030656
80	IKBKB	0.45357599
81	EIF2AK3	0.44744358
82	PRKCZ	0.44023064
83	TNK2	0.42996028
84	CSNK1A1	0.42717837
85	SRPK1	0.41713152
86	RPS6KA5	0.39229997
87	TIE1	0.38882923
88	PIK3CG	0.37024172
89	TSSK6	0.35768323
90	PKN1	0.35365819
91	PRKCA	0.35143249
92	CSNK1D	0.34525524
93	PTK2B	0.34355376
94	BRSK2	0.33891723
95	MAP2K2	0.33316988
96	OBSCN	0.33188423
97	ATM	0.33008136
98	ITK	0.32971673
99	PLK1	0.32063692
100	TAF1	0.31837780

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.96279970
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.75112794
3	Phototransduction_Homo sapiens_hsa04744	2.56543063
4	Protein export_Homo sapiens_hsa03060	2.49640256
5	Nicotine addiction_Homo sapiens_hsa05033	2.31576000
6	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.30777599
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.29306243
8	Homologous recombination_Homo sapiens_hsa03440	2.26252994
9	Oxidative phosphorylation_Homo sapiens_hsa00190	2.23550238
10	Selenocompound metabolism_Homo sapiens_hsa00450	2.22754483
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.19716333
12	Basal transcription factors_Homo sapiens_hsa03022	2.12857138
13	Nitrogen metabolism_Homo sapiens_hsa00910	2.11533319
14	Linoleic acid metabolism_Homo sapiens_hsa00591	2.07569269
15	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.03155455
16	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.01550310
17	Butanoate metabolism_Homo sapiens_hsa00650	1.97932122
18	RNA polymerase_Homo sapiens_hsa03020	1.92393532
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.90861971
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.87833968
21	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.81629352
22	RNA degradation_Homo sapiens_hsa03018	1.78782896
23	Parkinsons disease_Homo sapiens_hsa05012	1.73720251
24	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.66261325
25	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.60718777
26	Taste transduction_Homo sapiens_hsa04742	1.51690489
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.46156984
28	Olfactory transduction_Homo sapiens_hsa04740	1.44363598
29	Ether lipid metabolism_Homo sapiens_hsa00565	1.39144742
30	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.31708712
31	Morphine addiction_Homo sapiens_hsa05032	1.31128067
32	Mismatch repair_Homo sapiens_hsa03430	1.27323220
33	Huntingtons disease_Homo sapiens_hsa05016	1.23068304
34	Caffeine metabolism_Homo sapiens_hsa00232	1.22882685
35	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.18421850
36	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.18227506
37	GABAergic synapse_Homo sapiens_hsa04727	1.16875052
38	Propanoate metabolism_Homo sapiens_hsa00640	1.16182711
39	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.07374114
40	Regulation of autophagy_Homo sapiens_hsa04140	1.05408128
41	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.04411526
42	Collecting duct acid secretion_Homo sapiens_hsa04966	1.02960394
43	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.01887558
44	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.99634432
45	Primary immunodeficiency_Homo sapiens_hsa05340	0.99130351
46	Peroxisome_Homo sapiens_hsa04146	0.98975746
47	Cardiac muscle contraction_Homo sapiens_hsa04260	0.97650237
48	Circadian entrainment_Homo sapiens_hsa04713	0.94831111
49	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.94296875
50	Alzheimers disease_Homo sapiens_hsa05010	0.93047765
51	Retinol metabolism_Homo sapiens_hsa00830	0.92639766
52	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.91587637
53	Glutamatergic synapse_Homo sapiens_hsa04724	0.90940343
54	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.90779478
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.86205642
56	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.85274643
57	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.83802727
58	Insulin secretion_Homo sapiens_hsa04911	0.82836925
59	One carbon pool by folate_Homo sapiens_hsa00670	0.79890458
60	Purine metabolism_Homo sapiens_hsa00230	0.78108543
61	Serotonergic synapse_Homo sapiens_hsa04726	0.78057821
62	Sulfur metabolism_Homo sapiens_hsa00920	0.77353642
63	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.74274913
64	Steroid biosynthesis_Homo sapiens_hsa00100	0.73738126
65	Pyrimidine metabolism_Homo sapiens_hsa00240	0.71945949
66	Nucleotide excision repair_Homo sapiens_hsa03420	0.70804418
67	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.70150813
68	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.69968555
69	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.69561725
70	Dopaminergic synapse_Homo sapiens_hsa04728	0.68407078
71	Metabolic pathways_Homo sapiens_hsa01100	0.65111951
72	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.64418916
73	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.64305492
74	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.60934811
75	Cocaine addiction_Homo sapiens_hsa05030	0.58357274
76	Non-homologous end-joining_Homo sapiens_hsa03450	0.56180381
77	Long-term depression_Homo sapiens_hsa04730	0.55877306
78	Proteasome_Homo sapiens_hsa03050	0.55779320
79	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.53778526
80	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.53444406
81	RNA transport_Homo sapiens_hsa03013	0.51676758
82	Calcium signaling pathway_Homo sapiens_hsa04020	0.51001142
83	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.50115144
84	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.48589863
85	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.48458591
86	Amphetamine addiction_Homo sapiens_hsa05031	0.47922079
87	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.47081344
88	ABC transporters_Homo sapiens_hsa02010	0.46761831
89	Basal cell carcinoma_Homo sapiens_hsa05217	0.46055409
90	Fat digestion and absorption_Homo sapiens_hsa04975	0.44664706
91	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.43960144
92	Circadian rhythm_Homo sapiens_hsa04710	0.42083016
93	Cholinergic synapse_Homo sapiens_hsa04725	0.42015008
94	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.38581810
95	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.38040728
96	Mineral absorption_Homo sapiens_hsa04978	0.34774091
97	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.34150771
98	Salivary secretion_Homo sapiens_hsa04970	0.33067872
99	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.32607149
100	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.30591204

ZNF90P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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