

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | positive regulation of hematopoietic progenitor cell differentiation (GO:1901534) | 9.59049103 |
| 2 | snRNA processing (GO:0016180) | 8.01823433 |
| 3 | snRNA metabolic process (GO:0016073) | 7.66830086 |
| 4 | mRNA modification (GO:0016556) | 7.15834022 |
| 5 | terpenoid biosynthetic process (GO:0016114) | 6.95634392 |
| 6 | negative regulation of nitric-oxide synthase activity (GO:0051001) | 6.14565955 |
| 7 | radial glial cell differentiation (GO:0060019) | 5.92255508 |
| 8 | regulation of hematopoietic progenitor cell differentiation (GO:1901532) | 5.72958814 |
| 9 | regulation of megakaryocyte differentiation (GO:0045652) | 5.46573435 |
| 10 | Rap protein signal transduction (GO:0032486) | 5.39712747 |
| 11 | nerve growth factor signaling pathway (GO:0038180) | 5.29825659 |
| 12 | negative regulation of mesenchymal cell apoptotic process (GO:2001054) | 5.07058746 |
| 13 | positive regulation of triglyceride biosynthetic process (GO:0010867) | 5.02192824 |
| 14 | positive regulation of erythrocyte differentiation (GO:0045648) | 5.01747928 |
| 15 | positive regulation of cAMP-mediated signaling (GO:0043950) | 4.99960404 |
| 16 | negative regulation of monooxygenase activity (GO:0032769) | 4.91972093 |
| 17 | negative regulation of hematopoietic progenitor cell differentiation (GO:1901533) | 4.89061951 |
| 18 | fatty acid elongation (GO:0030497) | 4.83771655 |
| 19 | response to pheromone (GO:0019236) | 4.82313765 |
| 20 | cellular response to interferon-beta (GO:0035458) | 4.79855744 |
| 21 | negative regulation of oligodendrocyte differentiation (GO:0048715) | 4.79808148 |
| 22 | regulation of cAMP-dependent protein kinase activity (GO:2000479) | 4.78300182 |
| 23 | regulation of DNA endoreduplication (GO:0032875) | 4.75596350 |
| 24 | adrenergic receptor signaling pathway (GO:0071875) | 4.72498766 |
| 25 | intraciliary transport (GO:0042073) | 4.71829869 |
| 26 | positive regulation of vasculogenesis (GO:2001214) | 4.68480440 |
| 27 | negative regulation of dendrite morphogenesis (GO:0050774) | 4.65559389 |
| 28 | mitotic cell cycle arrest (GO:0071850) | 4.57015801 |
| 29 | regulation of cardioblast proliferation (GO:0003264) | 4.54029129 |
| 30 | regulation of secondary heart field cardioblast proliferation (GO:0003266) | 4.54029129 |
| 31 | G-protein coupled receptor internalization (GO:0002031) | 4.52722631 |
| 32 | positive regulation of receptor biosynthetic process (GO:0010870) | 4.40430415 |
| 33 | artery development (GO:0060840) | 4.38205450 |
| 34 | regulation of triglyceride biosynthetic process (GO:0010866) | 4.34187022 |
| 35 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 4.32211688 |
| 36 | protein localization to cilium (GO:0061512) | 4.30568077 |
| 37 | positive regulation of astrocyte differentiation (GO:0048711) | 4.29482404 |
| 38 | water-soluble vitamin biosynthetic process (GO:0042364) | 4.25111261 |
| 39 | neuronal stem cell maintenance (GO:0097150) | 4.21998966 |
| 40 | long-chain fatty acid biosynthetic process (GO:0042759) | 4.16657079 |
| 41 | cullin deneddylation (GO:0010388) | 4.05236611 |
| 42 | regulation of mesenchymal cell apoptotic process (GO:2001053) | 4.03876768 |
| 43 | pre-miRNA processing (GO:0031054) | 4.01828545 |
| 44 | nephron tubule morphogenesis (GO:0072078) | 3.98536274 |
| 45 | nephron epithelium morphogenesis (GO:0072088) | 3.98536274 |
| 46 | negative regulation of mast cell activation (GO:0033004) | 3.95196433 |
| 47 | pyrimidine dimer repair (GO:0006290) | 3.91616950 |
| 48 | positive regulation of microtubule polymerization (GO:0031116) | 3.90188847 |
| 49 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.84928881 |
| 50 | behavioral response to ethanol (GO:0048149) | 3.78378495 |
| 51 | mechanosensory behavior (GO:0007638) | 3.77382857 |
| 52 | positive regulation of gluconeogenesis (GO:0045722) | 3.74996498 |
| 53 | positive regulation of leukocyte apoptotic process (GO:2000108) | 3.71591584 |
| 54 | regulation of oxidative stress-induced neuron death (GO:1903203) | 3.59834276 |
| 55 | negative regulation of B cell apoptotic process (GO:0002903) | 3.52369848 |
| 56 | retinal rod cell development (GO:0046548) | 3.48814460 |
| 57 | protein deneddylation (GO:0000338) | 3.47682270 |
| 58 | L-fucose catabolic process (GO:0042355) | 3.43765375 |
| 59 | fucose catabolic process (GO:0019317) | 3.43765375 |
| 60 | L-fucose metabolic process (GO:0042354) | 3.43765375 |
| 61 | ventricular septum development (GO:0003281) | 3.39392403 |
| 62 | neuron fate determination (GO:0048664) | 3.35897150 |
| 63 | regulation of cAMP-mediated signaling (GO:0043949) | 3.35132424 |
| 64 | renal tubule morphogenesis (GO:0061333) | 3.34033854 |
| 65 | negative regulation of glial cell proliferation (GO:0060253) | 3.32703987 |
| 66 | cilium or flagellum-dependent cell motility (GO:0001539) | 3.31893579 |
| 67 | regulation of vasculogenesis (GO:2001212) | 3.31855655 |
| 68 | negative regulation of dendrite development (GO:2000171) | 3.31462749 |
| 69 | negative regulation of gene silencing (GO:0060969) | 3.28688572 |
| 70 | regulation of cellular senescence (GO:2000772) | 3.25865955 |
| 71 | peripheral nervous system neuron development (GO:0048935) | 3.25230869 |
| 72 | ventricular system development (GO:0021591) | 3.16658831 |
| 73 | S-adenosylmethionine metabolic process (GO:0046500) | 3.13795154 |
| 74 | regulation of B cell apoptotic process (GO:0002902) | 3.12950412 |
| 75 | potassium ion import (GO:0010107) | 3.11039251 |
| 76 | L-methionine salvage (GO:0071267) | 3.08829006 |
| 77 | L-methionine biosynthetic process (GO:0071265) | 3.08829006 |
| 78 | amino acid salvage (GO:0043102) | 3.08829006 |
| 79 | ADP metabolic process (GO:0046031) | 3.07777620 |
| 80 | left/right pattern formation (GO:0060972) | 3.07073919 |
| 81 | epithelial cilium movement (GO:0003351) | 3.05684578 |
| 82 | positive regulation of cholesterol efflux (GO:0010875) | 3.01889016 |
| 83 | cilium movement (GO:0003341) | 3.00920164 |
| 84 | negative regulation of multicellular organism growth (GO:0040015) | 2.99938303 |
| 85 | regulation of microtubule polymerization (GO:0031113) | 2.99832702 |
| 86 | protein homotrimerization (GO:0070207) | 2.98841106 |
| 87 | forebrain neuron development (GO:0021884) | 2.98243093 |
| 88 | positive regulation of triglyceride metabolic process (GO:0090208) | 2.97821545 |
| 89 | regulation of neuron migration (GO:2001222) | 2.95426441 |
| 90 | positive regulation of chondrocyte differentiation (GO:0032332) | 2.94096547 |
| 91 | heparin metabolic process (GO:0030202) | 2.91777167 |
| 92 | heparin biosynthetic process (GO:0030210) | 2.91777167 |
| 93 | negative regulation of epidermal cell differentiation (GO:0045605) | 2.91625826 |
| 94 | cellular response to nerve growth factor stimulus (GO:1990090) | 2.90130474 |
| 95 | response to nerve growth factor (GO:1990089) | 2.90130474 |
| 96 | carnitine shuttle (GO:0006853) | 2.90123479 |
| 97 | inner ear receptor stereocilium organization (GO:0060122) | 2.89786114 |
| 98 | mitochondrion morphogenesis (GO:0070584) | 2.83250297 |
| 99 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 2.81947791 |
| 100 | positive regulation of megakaryocyte differentiation (GO:0045654) | 11.0422291 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 5.59543481 |
| 2 | ZNF274_21170338_ChIP-Seq_K562_Hela | 5.58093398 |
| 3 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 3.81344805 |
| 4 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 3.74124264 |
| 5 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 3.05826360 |
| 6 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.86470780 |
| 7 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.85186105 |
| 8 | FUS_26573619_Chip-Seq_HEK293_Human | 2.81187623 |
| 9 | VDR_22108803_ChIP-Seq_LS180_Human | 2.75390649 |
| 10 | IRF1_19129219_ChIP-ChIP_H3396_Human | 2.34019255 |
| 11 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 2.29437334 |
| 12 | EGR1_19032775_ChIP-ChIP_M12_Human | 2.17721010 |
| 13 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.16647982 |
| 14 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.95125526 |
| 15 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.93457942 |
| 16 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.77192457 |
| 17 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.74975177 |
| 18 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.74800650 |
| 19 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.74586247 |
| 20 | EWS_26573619_Chip-Seq_HEK293_Human | 1.74417204 |
| 21 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.71677054 |
| 22 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.67804251 |
| 23 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.66297202 |
| 24 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.60787758 |
| 25 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.59894687 |
| 26 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.59894687 |
| 27 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.58639923 |
| 28 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.56226947 |
| 29 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.51040362 |
| 30 | AR_25329375_ChIP-Seq_VCAP_Human | 1.50320180 |
| 31 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.48872812 |
| 32 | RXR_22108803_ChIP-Seq_LS180_Human | 1.45721110 |
| 33 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 1.42627294 |
| 34 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.42460598 |
| 35 | AR_20517297_ChIP-Seq_VCAP_Human | 1.41165374 |
| 36 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.39902754 |
| 37 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.35867596 |
| 38 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.30536204 |
| 39 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.26709792 |
| 40 | P300_19829295_ChIP-Seq_ESCs_Human | 1.25976618 |
| 41 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.24458986 |
| 42 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.22676313 |
| 43 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.22352813 |
| 44 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.21942016 |
| 45 | TCF4_23295773_ChIP-Seq_U87_Human | 1.21455120 |
| 46 | NCOR_22424771_ChIP-Seq_293T_Human | 1.21151669 |
| 47 | ETV1_20927104_ChIP-Seq_GIST48_Human | 1.20791195 |
| 48 | TP53_16413492_ChIP-PET_HCT116_Human | 1.20422840 |
| 49 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.20072813 |
| 50 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.19448737 |
| 51 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 1.16882184 |
| 52 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.16133249 |
| 53 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.15866287 |
| 54 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.15546919 |
| 55 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.15244248 |
| 56 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.14441707 |
| 57 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 1.14123883 |
| 58 | SOX9_26525672_Chip-Seq_Limbbuds_Mouse | 1.11958564 |
| 59 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.11527576 |
| 60 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.09940097 |
| 61 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.09834330 |
| 62 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.09602910 |
| 63 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.09310637 |
| 64 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 1.07740944 |
| 65 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.07505364 |
| 66 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.06737361 |
| 67 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.05155822 |
| 68 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.05155822 |
| 69 | PHF8_20622853_ChIP-Seq_HELA_Human | 1.04669923 |
| 70 | PCGF4_22325352_ChIP-Seq_293T-Rex_Human | 1.03894902 |
| 71 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.02843920 |
| 72 | CBX2_22325352_ChIP-Seq_293T-Rex_Human | 1.02628546 |
| 73 | GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.02496949 |
| 74 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 1.01353873 |
| 75 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 1.01353873 |
| 76 | CDX2_21074721_ChIP-Seq_CACO-2_Mouse | 1.00610344 |
| 77 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.98979116 |
| 78 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.97706904 |
| 79 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.97697995 |
| 80 | STAT3_23295773_ChIP-Seq_U87_Human | 0.96879701 |
| 81 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.96220580 |
| 82 | TBL1_22424771_ChIP-Seq_293T_Human | 0.93905178 |
| 83 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 0.93766395 |
| 84 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.92754350 |
| 85 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 0.92469423 |
| 86 | NFYB_21822215_ChIP-Seq_K562_Human | 0.88616362 |
| 87 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.88025986 |
| 88 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 0.87491147 |
| 89 | MYC_19829295_ChIP-Seq_ESCs_Human | 0.86917837 |
| 90 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.85855022 |
| 91 | PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human | 0.84125013 |
| 92 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 0.83762586 |
| 93 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.83052113 |
| 94 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 0.82558096 |
| 95 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.81619140 |
| 96 | SOX9_26525672_Chip-Seq_HEART_Mouse | 0.81541708 |
| 97 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 0.81522647 |
| 98 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.81391811 |
| 99 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.81109796 |
| 100 | TP53_18474530_ChIP-ChIP_U2OS_Human | 0.80978903 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002139_abnormal_hepatobiliary_system | 5.41343272 |
| 2 | MP0000566_synostosis | 4.58971284 |
| 3 | MP0004133_heterotaxia | 4.52438849 |
| 4 | MP0005187_abnormal_penis_morphology | 4.40662502 |
| 5 | MP0004885_abnormal_endolymph | 3.47820238 |
| 6 | MP0002254_reproductive_system_inflammat | 3.12146437 |
| 7 | MP0002638_abnormal_pupillary_reflex | 2.91507183 |
| 8 | MP0003119_abnormal_digestive_system | 2.63819803 |
| 9 | MP0005647_abnormal_sex_gland | 2.51638051 |
| 10 | MP0005084_abnormal_gallbladder_morpholo | 2.35900122 |
| 11 | MP0003191_abnormal_cellular_cholesterol | 2.33793662 |
| 12 | MP0005365_abnormal_bile_salt | 2.28515332 |
| 13 | MP0002938_white_spotting | 2.27095029 |
| 14 | MP0002138_abnormal_hepatobiliary_system | 2.17020147 |
| 15 | MP0004808_abnormal_hematopoietic_stem | 2.14046425 |
| 16 | MP0003136_yellow_coat_color | 2.13425881 |
| 17 | MP0005174_abnormal_tail_pigmentation | 2.07184661 |
| 18 | MP0003943_abnormal_hepatobiliary_system | 2.04010828 |
| 19 | MP0008057_abnormal_DNA_replication | 2.01198562 |
| 20 | MP0003075_altered_response_to | 2.00080534 |
| 21 | MP0003329_amyloid_beta_deposits | 1.89375048 |
| 22 | MP0003937_abnormal_limbs/digits/tail_de | 1.88134992 |
| 23 | MP0005197_abnormal_uvea_morphology | 1.81302598 |
| 24 | MP0003938_abnormal_ear_development | 1.74808531 |
| 25 | MP0009703_decreased_birth_body | 1.67706616 |
| 26 | MP0001346_abnormal_lacrimal_gland | 1.63327707 |
| 27 | MP0001984_abnormal_olfaction | 1.63203326 |
| 28 | MP0005397_hematopoietic_system_phenotyp | 1.59103928 |
| 29 | MP0001545_abnormal_hematopoietic_system | 1.59103928 |
| 30 | MP0001348_abnormal_lacrimal_gland | 1.58731795 |
| 31 | MP0005394_taste/olfaction_phenotype | 1.56049383 |
| 32 | MP0005499_abnormal_olfactory_system | 1.56049383 |
| 33 | MP0001764_abnormal_homeostasis | 1.55643587 |
| 34 | MP0003880_abnormal_central_pattern | 1.55470093 |
| 35 | MP0000647_abnormal_sebaceous_gland | 1.54706777 |
| 36 | MP0000026_abnormal_inner_ear | 1.50766598 |
| 37 | MP0005165_increased_susceptibility_to | 1.49974071 |
| 38 | MP0000015_abnormal_ear_pigmentation | 1.49666797 |
| 39 | MP0000372_irregular_coat_pigmentation | 1.41906449 |
| 40 | MP0000613_abnormal_salivary_gland | 1.35206025 |
| 41 | MP0008789_abnormal_olfactory_epithelium | 1.35068416 |
| 42 | MP0009053_abnormal_anal_canal | 1.24795394 |
| 43 | MP0008961_abnormal_basal_metabolism | 1.23432403 |
| 44 | MP0005646_abnormal_pituitary_gland | 1.20112414 |
| 45 | MP0001324_abnormal_eye_pigmentation | 1.16992326 |
| 46 | MP0005220_abnormal_exocrine_pancreas | 1.12571614 |
| 47 | MP0010329_abnormal_lipoprotein_level | 1.07971063 |
| 48 | MP0000516_abnormal_urinary_system | 1.07673403 |
| 49 | MP0005367_renal/urinary_system_phenotyp | 1.07673403 |
| 50 | MP0006292_abnormal_olfactory_placode | 1.04992484 |
| 51 | MP0005551_abnormal_eye_electrophysiolog | 1.04231832 |
| 52 | MP0000462_abnormal_digestive_system | 1.03938039 |
| 53 | MP0000631_abnormal_neuroendocrine_gland | 1.01622938 |
| 54 | MP0001502_abnormal_circadian_rhythm | 0.99392861 |
| 55 | MP0001286_abnormal_eye_development | 0.95836928 |
| 56 | MP0004381_abnormal_hair_follicle | 0.94914192 |
| 57 | MP0005360_urolithiasis | 0.94664610 |
| 58 | MP0002184_abnormal_innervation | 0.91035759 |
| 59 | MP0003868_abnormal_feces_composition | 0.90964121 |
| 60 | MP0005310_abnormal_salivary_gland | 0.90138901 |
| 61 | MP0002752_abnormal_somatic_nervous | 0.87053393 |
| 62 | MP0000604_amyloidosis | 0.86613766 |
| 63 | MP0009672_abnormal_birth_weight | 0.86232451 |
| 64 | MP0001879_abnormal_lymphatic_vessel | 0.84233322 |
| 65 | MP0004215_abnormal_myocardial_fiber | 0.82826337 |
| 66 | MP0003828_pulmonary_edema | 0.82352136 |
| 67 | MP0008932_abnormal_embryonic_tissue | 0.81039496 |
| 68 | MP0008872_abnormal_physiological_respon | 0.80187491 |
| 69 | MP0002697_abnormal_eye_size | 0.79757379 |
| 70 | MP0002876_abnormal_thyroid_physiology | 0.79604890 |
| 71 | MP0005448_abnormal_energy_balance | 0.77398749 |
| 72 | MP0002084_abnormal_developmental_patter | 0.76796314 |
| 73 | MP0000537_abnormal_urethra_morphology | 0.76777733 |
| 74 | MP0002075_abnormal_coat/hair_pigmentati | 0.76392663 |
| 75 | MP0002928_abnormal_bile_duct | 0.75964650 |
| 76 | MP0003959_abnormal_lean_body | 0.75059870 |
| 77 | MP0002163_abnormal_gland_morphology | 0.74392097 |
| 78 | MP0003385_abnormal_body_wall | 0.73537396 |
| 79 | MP0005195_abnormal_posterior_eye | 0.73010788 |
| 80 | MP0008995_early_reproductive_senescence | 0.72312498 |
| 81 | MP0005171_absent_coat_pigmentation | 0.71192595 |
| 82 | MP0000230_abnormal_systemic_arterial | 0.69045142 |
| 83 | MP0002282_abnormal_trachea_morphology | 0.67492891 |
| 84 | MP0003315_abnormal_perineum_morphology | 0.65864409 |
| 85 | MP0003787_abnormal_imprinting | 0.65436288 |
| 86 | MP0000955_abnormal_spinal_cord | 0.62363426 |
| 87 | MP0005381_digestive/alimentary_phenotyp | 0.61446738 |
| 88 | MP0010030_abnormal_orbit_morphology | 0.59484070 |
| 89 | MP0001919_abnormal_reproductive_system | 0.59472037 |
| 90 | MP0003935_abnormal_craniofacial_develop | 0.58702762 |
| 91 | MP0001963_abnormal_hearing_physiology | 0.57861542 |
| 92 | MP0002095_abnormal_skin_pigmentation | 0.57634828 |
| 93 | MP0009115_abnormal_fat_cell | 0.57253807 |
| 94 | MP0003866_abnormal_defecation | 0.56725141 |
| 95 | MP0002971_abnormal_brown_adipose | 0.55888895 |
| 96 | MP0002249_abnormal_larynx_morphology | 0.55123691 |
| 97 | MP0008877_abnormal_DNA_methylation | 0.54212029 |
| 98 | MP0002272_abnormal_nervous_system | 0.52826502 |
| 99 | MP0003123_paternal_imprinting | 0.52642353 |
| 100 | MP0005334_abnormal_fat_pad | 0.51852207 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Arthropathy (HP:0003040) | 5.45169201 |
| 2 | Recurrent corneal erosions (HP:0000495) | 5.08459333 |
| 3 | Alacrima (HP:0000522) | 5.04012265 |
| 4 | Fibular aplasia (HP:0002990) | 4.89550278 |
| 5 | Progressive inability to walk (HP:0002505) | 4.81415284 |
| 6 | Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026) | 4.74746429 |
| 7 | Short 1st metacarpal (HP:0010034) | 4.74746429 |
| 8 | Severe visual impairment (HP:0001141) | 4.49348951 |
| 9 | Polydipsia (HP:0001959) | 4.41043215 |
| 10 | Abnormal drinking behavior (HP:0030082) | 4.41043215 |
| 11 | Short tibia (HP:0005736) | 4.27711665 |
| 12 | Tubular atrophy (HP:0000092) | 4.24322404 |
| 13 | Abnormality of the 1st metacarpal (HP:0010009) | 4.20278644 |
| 14 | Decreased lacrimation (HP:0000633) | 4.13699892 |
| 15 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 3.99480295 |
| 16 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 3.96712524 |
| 17 | Abnormality of the proximal phalanges of the hand (HP:0009834) | 3.72137291 |
| 18 | Fibular hypoplasia (HP:0003038) | 3.49666717 |
| 19 | Episodic fever (HP:0001954) | 3.48793787 |
| 20 | Nephronophthisis (HP:0000090) | 3.44341203 |
| 21 | Abnormality of the phalanges of the 2nd finger (HP:0009541) | 3.42865400 |
| 22 | Supernumerary spleens (HP:0009799) | 3.42432175 |
| 23 | Aplasia/Hypoplasia of the hallux (HP:0008362) | 3.42116624 |
| 24 | Enlarged kidneys (HP:0000105) | 3.39410267 |
| 25 | Humeroradial synostosis (HP:0003041) | 3.35793679 |
| 26 | Synostosis involving the elbow (HP:0003938) | 3.35793679 |
| 27 | Anomalous pulmonary venous return (HP:0010772) | 3.35598835 |
| 28 | Short hallux (HP:0010109) | 3.25774327 |
| 29 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 3.21438794 |
| 30 | Orthostatic hypotension (HP:0001278) | 3.18309869 |
| 31 | Double outlet right ventricle (HP:0001719) | 3.17919288 |
| 32 | Congenital malformation of the right heart (HP:0011723) | 3.17919288 |
| 33 | Abnormality of the renal cortex (HP:0011035) | 3.15434257 |
| 34 | Adactyly (HP:0009776) | 3.14448411 |
| 35 | Atonic seizures (HP:0010819) | 3.10459329 |
| 36 | Congenital stationary night blindness (HP:0007642) | 3.07193604 |
| 37 | Amblyopia (HP:0000646) | 3.00943826 |
| 38 | Aplasia/hypoplasia of the humerus (HP:0006507) | 3.00020600 |
| 39 | Mesomelia (HP:0003027) | 2.96399253 |
| 40 | Aplasia/Hypoplasia of the fibula (HP:0006492) | 2.94982061 |
| 41 | Abnormality of the renal medulla (HP:0100957) | 2.94710402 |
| 42 | Abnormality of the pulmonary veins (HP:0011718) | 2.91908176 |
| 43 | Abnormality of the middle phalanges of the toes (HP:0010183) | 2.88170542 |
| 44 | Short phalanx of the thumb (HP:0009660) | 2.84786743 |
| 45 | Polyuria (HP:0000103) | 2.83492571 |
| 46 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 2.78639824 |
| 47 | Malignant hyperthermia (HP:0002047) | 2.76755210 |
| 48 | Inability to walk (HP:0002540) | 2.74965530 |
| 49 | Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173) | 2.71141275 |
| 50 | Volvulus (HP:0002580) | 2.59524547 |
| 51 | Preauricular pit (HP:0004467) | 2.58247495 |
| 52 | Periauricular skin pits (HP:0100277) | 2.58247495 |
| 53 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 2.57782746 |
| 54 | Absent epiphyses (HP:0010577) | 2.57782746 |
| 55 | Abnormality of the middle phalanx of the 5th finger (HP:0004219) | 2.56208064 |
| 56 | Short humerus (HP:0005792) | 2.54810236 |
| 57 | Asplenia (HP:0001746) | 2.48056426 |
| 58 | Heterochromia iridis (HP:0001100) | 2.43951077 |
| 59 | Pancreatic cysts (HP:0001737) | 2.43351579 |
| 60 | Tubulointerstitial fibrosis (HP:0005576) | 2.39993935 |
| 61 | Renal dysplasia (HP:0000110) | 2.39933468 |
| 62 | Enlarged epiphyses (HP:0010580) | 2.38210279 |
| 63 | Abnormality of the phalanges of the 5th finger (HP:0004213) | 2.38129747 |
| 64 | Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161) | 2.37861753 |
| 65 | Deformed tarsal bones (HP:0008119) | 2.34356194 |
| 66 | Abnormal urine output (HP:0012590) | 2.29976711 |
| 67 | Broad hallux (HP:0010055) | 2.27272674 |
| 68 | Patchy hypopigmentation of hair (HP:0011365) | 2.23705682 |
| 69 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 2.22324222 |
| 70 | Severe muscular hypotonia (HP:0006829) | 2.20649094 |
| 71 | Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376) | 2.18299243 |
| 72 | Hyponatremia (HP:0002902) | 2.18016350 |
| 73 | Radial bowing (HP:0002986) | 2.16008529 |
| 74 | Symphalangism affecting the phalanges of the hand (HP:0009773) | 2.15585250 |
| 75 | Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658) | 2.12428004 |
| 76 | Abnormal lung lobation (HP:0002101) | 2.09908472 |
| 77 | Broad toe (HP:0001837) | 2.09566794 |
| 78 | Tubulointerstitial abnormality (HP:0001969) | 2.09483524 |
| 79 | Abnormal hair whorl (HP:0010721) | 2.09172790 |
| 80 | Cerebellar dysplasia (HP:0007033) | 2.08063730 |
| 81 | Stage 5 chronic kidney disease (HP:0003774) | 2.05309490 |
| 82 | Aplasia/hypoplasia of the femur (HP:0005613) | 2.02167941 |
| 83 | True hermaphroditism (HP:0010459) | 2.01820168 |
| 84 | Abnormality of the peritoneum (HP:0002585) | 2.01586966 |
| 85 | Abnormality of the 2nd finger (HP:0004100) | 1.98150313 |
| 86 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.97713635 |
| 87 | 3-Methylglutaconic aciduria (HP:0003535) | 1.92821415 |
| 88 | Dyskinesia (HP:0100660) | 1.91271519 |
| 89 | Congenital hepatic fibrosis (HP:0002612) | 1.90544127 |
| 90 | White forelock (HP:0002211) | 1.87484266 |
| 91 | Abnormality of renal excretion (HP:0011036) | 1.86717792 |
| 92 | Hypoproteinemia (HP:0003075) | 1.85360730 |
| 93 | Glomerulosclerosis (HP:0000096) | 1.83538907 |
| 94 | Abnormality of the anterior horn cell (HP:0006802) | 1.76816551 |
| 95 | Degeneration of anterior horn cells (HP:0002398) | 1.76816551 |
| 96 | Leukodystrophy (HP:0002415) | 1.72520337 |
| 97 | Prolonged neonatal jaundice (HP:0006579) | 1.72505370 |
| 98 | Aplasia/Hypoplasia of the ulna (HP:0006495) | 1.70338407 |
| 99 | Loss of speech (HP:0002371) | 1.70058674 |
| 100 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.69911772 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | STK39 | 7.12276857 |
| 2 | WNK4 | 6.95285396 |
| 3 | PRKD3 | 3.71854137 |
| 4 | RIPK1 | 3.14608656 |
| 5 | WNK3 | 2.98015960 |
| 6 | CASK | 2.95515499 |
| 7 | LMTK2 | 2.89995970 |
| 8 | FGR | 2.72757579 |
| 9 | EPHA4 | 2.64119953 |
| 10 | JAK3 | 2.47631940 |
| 11 | SRPK1 | 2.25236912 |
| 12 | EPHA3 | 2.20770226 |
| 13 | WNK1 | 2.15846624 |
| 14 | IRAK1 | 1.85382396 |
| 15 | TNIK | 1.79802519 |
| 16 | FER | 1.68485671 |
| 17 | YES1 | 1.64007454 |
| 18 | DYRK3 | 1.62244153 |
| 19 | PLK2 | 1.58827114 |
| 20 | PRKCQ | 1.55075008 |
| 21 | PHKG2 | 1.30722875 |
| 22 | PHKG1 | 1.30722875 |
| 23 | NLK | 1.27952460 |
| 24 | PDK2 | 1.27265543 |
| 25 | DYRK1A | 1.24818808 |
| 26 | GRK1 | 1.23153628 |
| 27 | FRK | 1.09283799 |
| 28 | RPS6KA5 | 1.05290913 |
| 29 | ADRBK2 | 1.00752781 |
| 30 | MAP3K13 | 0.89301620 |
| 31 | STK38L | 0.87693314 |
| 32 | IRAK4 | 0.87295428 |
| 33 | MAP4K2 | 0.85330987 |
| 34 | PLK3 | 0.84155753 |
| 35 | PRKCI | 0.78516587 |
| 36 | FGFR4 | 0.77257208 |
| 37 | BMPR1B | 0.77072972 |
| 38 | EPHA2 | 0.76763085 |
| 39 | CAMK1D | 0.72886623 |
| 40 | ITK | 0.71356618 |
| 41 | CHUK | 0.69866658 |
| 42 | MAPKAPK2 | 0.66394115 |
| 43 | ADRBK1 | 0.63977792 |
| 44 | NUAK1 | 0.63617913 |
| 45 | SCYL2 | 0.63057720 |
| 46 | MARK2 | 0.61120204 |
| 47 | DYRK2 | 0.59502642 |
| 48 | EPHB1 | 0.59233753 |
| 49 | TLK1 | 0.58045912 |
| 50 | ATR | 0.54220809 |
| 51 | DDR2 | 0.51065960 |
| 52 | IRAK2 | 0.49948871 |
| 53 | EIF2AK1 | 0.48447924 |
| 54 | MAPK13 | 0.46327879 |
| 55 | PIM2 | 0.45854361 |
| 56 | MKNK1 | 0.45031202 |
| 57 | CAMKK2 | 0.43521952 |
| 58 | DAPK2 | 0.43293560 |
| 59 | BRD4 | 0.43057606 |
| 60 | PRKCE | 0.42510040 |
| 61 | BRSK2 | 0.41979319 |
| 62 | IKBKB | 0.41570303 |
| 63 | EGFR | 0.37139538 |
| 64 | CAMK2B | 0.35386520 |
| 65 | INSRR | 0.34030335 |
| 66 | CSNK1D | 0.33731185 |
| 67 | PRKDC | 0.33492118 |
| 68 | GRK7 | 0.32043922 |
| 69 | MAPK15 | 0.31748880 |
| 70 | NTRK3 | 0.30501987 |
| 71 | TSSK6 | 0.30152508 |
| 72 | PRKACA | 0.30149172 |
| 73 | OBSCN | 0.29594867 |
| 74 | MARK3 | 0.27857461 |
| 75 | EPHB2 | 0.27315248 |
| 76 | PLK1 | 0.26147352 |
| 77 | PLK4 | 0.25947530 |
| 78 | MKNK2 | 0.25766746 |
| 79 | PDGFRB | 0.25675204 |
| 80 | CSNK1A1 | 0.25483185 |
| 81 | CAMK2A | 0.24461061 |
| 82 | RPS6KA4 | 0.24125031 |
| 83 | PRKG1 | 0.23674583 |
| 84 | PRKACB | 0.23101601 |
| 85 | PRKCA | 0.22034339 |
| 86 | GRK5 | 0.20721539 |
| 87 | GSK3B | 0.20627299 |
| 88 | ATM | 0.20401950 |
| 89 | MARK1 | 0.18880121 |
| 90 | NME2 | 0.18724475 |
| 91 | CAMK2G | 0.16945993 |
| 92 | TGFBR1 | 0.15395211 |
| 93 | CDC42BPA | 0.15171320 |
| 94 | HCK | 0.14834495 |
| 95 | MAP2K6 | 0.14787950 |
| 96 | MAPKAPK5 | 0.14580098 |
| 97 | CDK8 | 0.14509605 |
| 98 | IKBKE | 0.14440363 |
| 99 | CDK3 | 0.14274878 |
| 100 | NTRK2 | 0.13982419 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 4.07341897 |
| 2 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 3.48409499 |
| 3 | Phototransduction_Homo sapiens_hsa04744 | 2.99100282 |
| 4 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 2.81153069 |
| 5 | Steroid biosynthesis_Homo sapiens_hsa00100 | 2.78622130 |
| 6 | Ether lipid metabolism_Homo sapiens_hsa00565 | 2.74020278 |
| 7 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 2.69546671 |
| 8 | Regulation of autophagy_Homo sapiens_hsa04140 | 2.66374252 |
| 9 | Fatty acid elongation_Homo sapiens_hsa00062 | 2.54258140 |
| 10 | Selenocompound metabolism_Homo sapiens_hsa00450 | 2.42507320 |
| 11 | Protein export_Homo sapiens_hsa03060 | 2.39134768 |
| 12 | Circadian rhythm_Homo sapiens_hsa04710 | 2.00083108 |
| 13 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.89378418 |
| 14 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.88082503 |
| 15 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.85572659 |
| 16 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 1.69580557 |
| 17 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.63879390 |
| 18 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.62278385 |
| 19 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.59173781 |
| 20 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.57825449 |
| 21 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.57227689 |
| 22 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.55596509 |
| 23 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.46938275 |
| 24 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.46665758 |
| 25 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.43407717 |
| 26 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.40701610 |
| 27 | Purine metabolism_Homo sapiens_hsa00230 | 1.34290753 |
| 28 | RNA degradation_Homo sapiens_hsa03018 | 1.34046519 |
| 29 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.23894199 |
| 30 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.23836955 |
| 31 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.23633777 |
| 32 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 1.23533729 |
| 33 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.23230385 |
| 34 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 1.22008178 |
| 35 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.21946029 |
| 36 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.21580829 |
| 37 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.19808493 |
| 38 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 1.16886059 |
| 39 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.11526507 |
| 40 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.11498305 |
| 41 | Morphine addiction_Homo sapiens_hsa05032 | 1.08912922 |
| 42 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.08632583 |
| 43 | Bile secretion_Homo sapiens_hsa04976 | 1.08590853 |
| 44 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.00200799 |
| 45 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.94584014 |
| 46 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.92573231 |
| 47 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.91481411 |
| 48 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.91061110 |
| 49 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.89193231 |
| 50 | Retinol metabolism_Homo sapiens_hsa00830 | 0.88887838 |
| 51 | RNA transport_Homo sapiens_hsa03013 | 0.80980026 |
| 52 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.80964435 |
| 53 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.79031493 |
| 54 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.76108919 |
| 55 | GABAergic synapse_Homo sapiens_hsa04727 | 0.74826257 |
| 56 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.74186945 |
| 57 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.69081202 |
| 58 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.68640525 |
| 59 | Spliceosome_Homo sapiens_hsa03040 | 0.65412958 |
| 60 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.65277857 |
| 61 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.62216028 |
| 62 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.61758127 |
| 63 | RNA polymerase_Homo sapiens_hsa03020 | 0.61597118 |
| 64 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.60897180 |
| 65 | Metabolic pathways_Homo sapiens_hsa01100 | 0.60640332 |
| 66 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.60109082 |
| 67 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.60015124 |
| 68 | Basal transcription factors_Homo sapiens_hsa03022 | 0.58161044 |
| 69 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.57786572 |
| 70 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.57585012 |
| 71 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.55841909 |
| 72 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.53585206 |
| 73 | Salivary secretion_Homo sapiens_hsa04970 | 0.52124843 |
| 74 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.50934122 |
| 75 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.50653495 |
| 76 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.48251417 |
| 77 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.47446037 |
| 78 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.46170573 |
| 79 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.44932562 |
| 80 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.44510951 |
| 81 | Taste transduction_Homo sapiens_hsa04742 | 0.44315675 |
| 82 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.42755421 |
| 83 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.41676435 |
| 84 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.40172202 |
| 85 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.40020446 |
| 86 | Olfactory transduction_Homo sapiens_hsa04740 | 0.39043113 |
| 87 | Huntingtons disease_Homo sapiens_hsa05016 | 0.38109789 |
| 88 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.36938471 |
| 89 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.34287431 |
| 90 | Peroxisome_Homo sapiens_hsa04146 | 0.34250802 |
| 91 | Insulin secretion_Homo sapiens_hsa04911 | 0.33119799 |
| 92 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.32604707 |
| 93 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.32462701 |
| 94 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.32434220 |
| 95 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.31886655 |
| 96 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.31262722 |
| 97 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.31188460 |
| 98 | Circadian entrainment_Homo sapiens_hsa04713 | 0.30196435 |
| 99 | Nicotine addiction_Homo sapiens_hsa05033 | 0.29361977 |
| 100 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.29082944 |

