ZNF90P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)9.59049103
2snRNA processing (GO:0016180)8.01823433
3snRNA metabolic process (GO:0016073)7.66830086
4mRNA modification (GO:0016556)7.15834022
5terpenoid biosynthetic process (GO:0016114)6.95634392
6negative regulation of nitric-oxide synthase activity (GO:0051001)6.14565955
7radial glial cell differentiation (GO:0060019)5.92255508
8regulation of hematopoietic progenitor cell differentiation (GO:1901532)5.72958814
9regulation of megakaryocyte differentiation (GO:0045652)5.46573435
10Rap protein signal transduction (GO:0032486)5.39712747
11nerve growth factor signaling pathway (GO:0038180)5.29825659
12negative regulation of mesenchymal cell apoptotic process (GO:2001054)5.07058746
13positive regulation of triglyceride biosynthetic process (GO:0010867)5.02192824
14positive regulation of erythrocyte differentiation (GO:0045648)5.01747928
15positive regulation of cAMP-mediated signaling (GO:0043950)4.99960404
16negative regulation of monooxygenase activity (GO:0032769)4.91972093
17negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.89061951
18fatty acid elongation (GO:0030497)4.83771655
19response to pheromone (GO:0019236)4.82313765
20cellular response to interferon-beta (GO:0035458)4.79855744
21negative regulation of oligodendrocyte differentiation (GO:0048715)4.79808148
22regulation of cAMP-dependent protein kinase activity (GO:2000479)4.78300182
23regulation of DNA endoreduplication (GO:0032875)4.75596350
24adrenergic receptor signaling pathway (GO:0071875)4.72498766
25intraciliary transport (GO:0042073)4.71829869
26positive regulation of vasculogenesis (GO:2001214)4.68480440
27negative regulation of dendrite morphogenesis (GO:0050774)4.65559389
28mitotic cell cycle arrest (GO:0071850)4.57015801
29regulation of cardioblast proliferation (GO:0003264)4.54029129
30regulation of secondary heart field cardioblast proliferation (GO:0003266)4.54029129
31G-protein coupled receptor internalization (GO:0002031)4.52722631
32positive regulation of receptor biosynthetic process (GO:0010870)4.40430415
33artery development (GO:0060840)4.38205450
34regulation of triglyceride biosynthetic process (GO:0010866)4.34187022
35epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.32211688
36protein localization to cilium (GO:0061512)4.30568077
37positive regulation of astrocyte differentiation (GO:0048711)4.29482404
38water-soluble vitamin biosynthetic process (GO:0042364)4.25111261
39neuronal stem cell maintenance (GO:0097150)4.21998966
40long-chain fatty acid biosynthetic process (GO:0042759)4.16657079
41cullin deneddylation (GO:0010388)4.05236611
42regulation of mesenchymal cell apoptotic process (GO:2001053)4.03876768
43pre-miRNA processing (GO:0031054)4.01828545
44nephron tubule morphogenesis (GO:0072078)3.98536274
45nephron epithelium morphogenesis (GO:0072088)3.98536274
46negative regulation of mast cell activation (GO:0033004)3.95196433
47pyrimidine dimer repair (GO:0006290)3.91616950
48positive regulation of microtubule polymerization (GO:0031116)3.90188847
49L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.84928881
50behavioral response to ethanol (GO:0048149)3.78378495
51mechanosensory behavior (GO:0007638)3.77382857
52positive regulation of gluconeogenesis (GO:0045722)3.74996498
53positive regulation of leukocyte apoptotic process (GO:2000108)3.71591584
54regulation of oxidative stress-induced neuron death (GO:1903203)3.59834276
55negative regulation of B cell apoptotic process (GO:0002903)3.52369848
56retinal rod cell development (GO:0046548)3.48814460
57protein deneddylation (GO:0000338)3.47682270
58L-fucose catabolic process (GO:0042355)3.43765375
59fucose catabolic process (GO:0019317)3.43765375
60L-fucose metabolic process (GO:0042354)3.43765375
61ventricular septum development (GO:0003281)3.39392403
62neuron fate determination (GO:0048664)3.35897150
63regulation of cAMP-mediated signaling (GO:0043949)3.35132424
64renal tubule morphogenesis (GO:0061333)3.34033854
65negative regulation of glial cell proliferation (GO:0060253)3.32703987
66cilium or flagellum-dependent cell motility (GO:0001539)3.31893579
67regulation of vasculogenesis (GO:2001212)3.31855655
68negative regulation of dendrite development (GO:2000171)3.31462749
69negative regulation of gene silencing (GO:0060969)3.28688572
70regulation of cellular senescence (GO:2000772)3.25865955
71peripheral nervous system neuron development (GO:0048935)3.25230869
72ventricular system development (GO:0021591)3.16658831
73S-adenosylmethionine metabolic process (GO:0046500)3.13795154
74regulation of B cell apoptotic process (GO:0002902)3.12950412
75potassium ion import (GO:0010107)3.11039251
76L-methionine salvage (GO:0071267)3.08829006
77L-methionine biosynthetic process (GO:0071265)3.08829006
78amino acid salvage (GO:0043102)3.08829006
79ADP metabolic process (GO:0046031)3.07777620
80left/right pattern formation (GO:0060972)3.07073919
81epithelial cilium movement (GO:0003351)3.05684578
82positive regulation of cholesterol efflux (GO:0010875)3.01889016
83cilium movement (GO:0003341)3.00920164
84negative regulation of multicellular organism growth (GO:0040015)2.99938303
85regulation of microtubule polymerization (GO:0031113)2.99832702
86protein homotrimerization (GO:0070207)2.98841106
87forebrain neuron development (GO:0021884)2.98243093
88positive regulation of triglyceride metabolic process (GO:0090208)2.97821545
89regulation of neuron migration (GO:2001222)2.95426441
90positive regulation of chondrocyte differentiation (GO:0032332)2.94096547
91heparin metabolic process (GO:0030202)2.91777167
92heparin biosynthetic process (GO:0030210)2.91777167
93negative regulation of epidermal cell differentiation (GO:0045605)2.91625826
94cellular response to nerve growth factor stimulus (GO:1990090)2.90130474
95response to nerve growth factor (GO:1990089)2.90130474
96carnitine shuttle (GO:0006853)2.90123479
97inner ear receptor stereocilium organization (GO:0060122)2.89786114
98mitochondrion morphogenesis (GO:0070584)2.83250297
99negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.81947791
100positive regulation of megakaryocyte differentiation (GO:0045654)11.0422291

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human5.59543481
2ZNF274_21170338_ChIP-Seq_K562_Hela5.58093398
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.81344805
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.74124264
5NOTCH1_21737748_ChIP-Seq_TLL_Human3.05826360
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.86470780
7TAF15_26573619_Chip-Seq_HEK293_Human2.85186105
8FUS_26573619_Chip-Seq_HEK293_Human2.81187623
9VDR_22108803_ChIP-Seq_LS180_Human2.75390649
10IRF1_19129219_ChIP-ChIP_H3396_Human2.34019255
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.29437334
12EGR1_19032775_ChIP-ChIP_M12_Human2.17721010
13PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.16647982
14UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.95125526
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.93457942
16IGF1R_20145208_ChIP-Seq_DFB_Human1.77192457
17ZFP57_27257070_Chip-Seq_ESCs_Mouse1.74975177
18PIAS1_25552417_ChIP-Seq_VCAP_Human1.74800650
19CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.74586247
20EWS_26573619_Chip-Seq_HEK293_Human1.74417204
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71677054
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67804251
23AUTS2_25519132_ChIP-Seq_293T-REX_Human1.66297202
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60787758
25NANOG_19829295_ChIP-Seq_ESCs_Human1.59894687
26SOX2_19829295_ChIP-Seq_ESCs_Human1.59894687
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58639923
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.56226947
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.51040362
30AR_25329375_ChIP-Seq_VCAP_Human1.50320180
31TP53_22573176_ChIP-Seq_HFKS_Human1.48872812
32RXR_22108803_ChIP-Seq_LS180_Human1.45721110
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.42627294
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42460598
35AR_20517297_ChIP-Seq_VCAP_Human1.41165374
36GATA1_26923725_Chip-Seq_HPCs_Mouse1.39902754
37GABP_17652178_ChIP-ChIP_JURKAT_Human1.35867596
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30536204
39CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26709792
40P300_19829295_ChIP-Seq_ESCs_Human1.25976618
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24458986
42GBX2_23144817_ChIP-Seq_PC3_Human1.22676313
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.22352813
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.21942016
45TCF4_23295773_ChIP-Seq_U87_Human1.21455120
46NCOR_22424771_ChIP-Seq_293T_Human1.21151669
47ETV1_20927104_ChIP-Seq_GIST48_Human1.20791195
48TP53_16413492_ChIP-PET_HCT116_Human1.20422840
49TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20072813
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19448737
51CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.16882184
52RNF2_27304074_Chip-Seq_NSC_Mouse1.16133249
53GATA3_21878914_ChIP-Seq_MCF-7_Human1.15866287
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15546919
55RUNX2_22187159_ChIP-Seq_PCA_Human1.15244248
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14441707
57TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.14123883
58SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.11958564
59MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11527576
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09940097
61FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09834330
62NANOG_18555785_Chip-Seq_ESCs_Mouse1.09602910
63NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09310637
64ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07740944
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.07505364
66FOXP3_21729870_ChIP-Seq_TREG_Human1.06737361
67CBP_20019798_ChIP-Seq_JUKART_Human1.05155822
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05155822
69PHF8_20622853_ChIP-Seq_HELA_Human1.04669923
70PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.03894902
71NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.02843920
72CBX2_22325352_ChIP-Seq_293T-Rex_Human1.02628546
73GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.02496949
74NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01353873
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01353873
76CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.00610344
77HOXB7_26014856_ChIP-Seq_BT474_Human0.98979116
78ESR1_21235772_ChIP-Seq_MCF-7_Human0.97706904
79TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97697995
80STAT3_23295773_ChIP-Seq_U87_Human0.96879701
81BCAT_22108803_ChIP-Seq_LS180_Human0.96220580
82TBL1_22424771_ChIP-Seq_293T_Human0.93905178
83PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93766395
84KAP1_22055183_ChIP-Seq_ESCs_Mouse0.92754350
85SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92469423
86NFYB_21822215_ChIP-Seq_K562_Human0.88616362
87FOXA1_21572438_ChIP-Seq_LNCaP_Human0.88025986
88SRF_21415370_ChIP-Seq_HL-1_Mouse0.87491147
89MYC_19829295_ChIP-Seq_ESCs_Human0.86917837
90LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85855022
91PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.84125013
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.83762586
93RBPJ_21746931_ChIP-Seq_IB4_Human0.83052113
94TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.82558096
95MYCN_18555785_ChIP-Seq_MESCs_Mouse0.81619140
96SOX9_26525672_Chip-Seq_HEART_Mouse0.81541708
97EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.81522647
98RBPJ_22232070_ChIP-Seq_NCS_Mouse0.81391811
99KDM5A_27292631_Chip-Seq_BREAST_Human0.81109796
100TP53_18474530_ChIP-ChIP_U2OS_Human0.80978903

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.41343272
2MP0000566_synostosis4.58971284
3MP0004133_heterotaxia4.52438849
4MP0005187_abnormal_penis_morphology4.40662502
5MP0004885_abnormal_endolymph3.47820238
6MP0002254_reproductive_system_inflammat3.12146437
7MP0002638_abnormal_pupillary_reflex2.91507183
8MP0003119_abnormal_digestive_system2.63819803
9MP0005647_abnormal_sex_gland2.51638051
10MP0005084_abnormal_gallbladder_morpholo2.35900122
11MP0003191_abnormal_cellular_cholesterol2.33793662
12MP0005365_abnormal_bile_salt2.28515332
13MP0002938_white_spotting2.27095029
14MP0002138_abnormal_hepatobiliary_system2.17020147
15MP0004808_abnormal_hematopoietic_stem2.14046425
16MP0003136_yellow_coat_color2.13425881
17MP0005174_abnormal_tail_pigmentation2.07184661
18MP0003943_abnormal_hepatobiliary_system2.04010828
19MP0008057_abnormal_DNA_replication2.01198562
20MP0003075_altered_response_to2.00080534
21MP0003329_amyloid_beta_deposits1.89375048
22MP0003937_abnormal_limbs/digits/tail_de1.88134992
23MP0005197_abnormal_uvea_morphology1.81302598
24MP0003938_abnormal_ear_development1.74808531
25MP0009703_decreased_birth_body1.67706616
26MP0001346_abnormal_lacrimal_gland1.63327707
27MP0001984_abnormal_olfaction1.63203326
28MP0005397_hematopoietic_system_phenotyp1.59103928
29MP0001545_abnormal_hematopoietic_system1.59103928
30MP0001348_abnormal_lacrimal_gland1.58731795
31MP0005394_taste/olfaction_phenotype1.56049383
32MP0005499_abnormal_olfactory_system1.56049383
33MP0001764_abnormal_homeostasis1.55643587
34MP0003880_abnormal_central_pattern1.55470093
35MP0000647_abnormal_sebaceous_gland1.54706777
36MP0000026_abnormal_inner_ear1.50766598
37MP0005165_increased_susceptibility_to1.49974071
38MP0000015_abnormal_ear_pigmentation1.49666797
39MP0000372_irregular_coat_pigmentation1.41906449
40MP0000613_abnormal_salivary_gland1.35206025
41MP0008789_abnormal_olfactory_epithelium1.35068416
42MP0009053_abnormal_anal_canal1.24795394
43MP0008961_abnormal_basal_metabolism1.23432403
44MP0005646_abnormal_pituitary_gland1.20112414
45MP0001324_abnormal_eye_pigmentation1.16992326
46MP0005220_abnormal_exocrine_pancreas1.12571614
47MP0010329_abnormal_lipoprotein_level1.07971063
48MP0000516_abnormal_urinary_system1.07673403
49MP0005367_renal/urinary_system_phenotyp1.07673403
50MP0006292_abnormal_olfactory_placode1.04992484
51MP0005551_abnormal_eye_electrophysiolog1.04231832
52MP0000462_abnormal_digestive_system1.03938039
53MP0000631_abnormal_neuroendocrine_gland1.01622938
54MP0001502_abnormal_circadian_rhythm0.99392861
55MP0001286_abnormal_eye_development0.95836928
56MP0004381_abnormal_hair_follicle0.94914192
57MP0005360_urolithiasis0.94664610
58MP0002184_abnormal_innervation0.91035759
59MP0003868_abnormal_feces_composition0.90964121
60MP0005310_abnormal_salivary_gland0.90138901
61MP0002752_abnormal_somatic_nervous0.87053393
62MP0000604_amyloidosis0.86613766
63MP0009672_abnormal_birth_weight0.86232451
64MP0001879_abnormal_lymphatic_vessel0.84233322
65MP0004215_abnormal_myocardial_fiber0.82826337
66MP0003828_pulmonary_edema0.82352136
67MP0008932_abnormal_embryonic_tissue0.81039496
68MP0008872_abnormal_physiological_respon0.80187491
69MP0002697_abnormal_eye_size0.79757379
70MP0002876_abnormal_thyroid_physiology0.79604890
71MP0005448_abnormal_energy_balance0.77398749
72MP0002084_abnormal_developmental_patter0.76796314
73MP0000537_abnormal_urethra_morphology0.76777733
74MP0002075_abnormal_coat/hair_pigmentati0.76392663
75MP0002928_abnormal_bile_duct0.75964650
76MP0003959_abnormal_lean_body0.75059870
77MP0002163_abnormal_gland_morphology0.74392097
78MP0003385_abnormal_body_wall0.73537396
79MP0005195_abnormal_posterior_eye0.73010788
80MP0008995_early_reproductive_senescence0.72312498
81MP0005171_absent_coat_pigmentation0.71192595
82MP0000230_abnormal_systemic_arterial0.69045142
83MP0002282_abnormal_trachea_morphology0.67492891
84MP0003315_abnormal_perineum_morphology0.65864409
85MP0003787_abnormal_imprinting0.65436288
86MP0000955_abnormal_spinal_cord0.62363426
87MP0005381_digestive/alimentary_phenotyp0.61446738
88MP0010030_abnormal_orbit_morphology0.59484070
89MP0001919_abnormal_reproductive_system0.59472037
90MP0003935_abnormal_craniofacial_develop0.58702762
91MP0001963_abnormal_hearing_physiology0.57861542
92MP0002095_abnormal_skin_pigmentation0.57634828
93MP0009115_abnormal_fat_cell0.57253807
94MP0003866_abnormal_defecation0.56725141
95MP0002971_abnormal_brown_adipose0.55888895
96MP0002249_abnormal_larynx_morphology0.55123691
97MP0008877_abnormal_DNA_methylation0.54212029
98MP0002272_abnormal_nervous_system0.52826502
99MP0003123_paternal_imprinting0.52642353
100MP0005334_abnormal_fat_pad0.51852207

Predicted human phenotypes

RankGene SetZ-score
1Arthropathy (HP:0003040)5.45169201
2Recurrent corneal erosions (HP:0000495)5.08459333
3Alacrima (HP:0000522)5.04012265
4Fibular aplasia (HP:0002990)4.89550278
5Progressive inability to walk (HP:0002505)4.81415284
6Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)4.74746429
7Short 1st metacarpal (HP:0010034)4.74746429
8Severe visual impairment (HP:0001141)4.49348951
9Polydipsia (HP:0001959)4.41043215
10Abnormal drinking behavior (HP:0030082)4.41043215
11Short tibia (HP:0005736)4.27711665
12Tubular atrophy (HP:0000092)4.24322404
13Abnormality of the 1st metacarpal (HP:0010009)4.20278644
14Decreased lacrimation (HP:0000633)4.13699892
15Aplasia/Hypoplasia of the tibia (HP:0005772)3.99480295
16Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.96712524
17Abnormality of the proximal phalanges of the hand (HP:0009834)3.72137291
18Fibular hypoplasia (HP:0003038)3.49666717
19Episodic fever (HP:0001954)3.48793787
20Nephronophthisis (HP:0000090)3.44341203
21Abnormality of the phalanges of the 2nd finger (HP:0009541)3.42865400
22Supernumerary spleens (HP:0009799)3.42432175
23Aplasia/Hypoplasia of the hallux (HP:0008362)3.42116624
24Enlarged kidneys (HP:0000105)3.39410267
25Humeroradial synostosis (HP:0003041)3.35793679
26Synostosis involving the elbow (HP:0003938)3.35793679
27Anomalous pulmonary venous return (HP:0010772)3.35598835
28Short hallux (HP:0010109)3.25774327
29Hypoplasia of the capital femoral epiphysis (HP:0003090)3.21438794
30Orthostatic hypotension (HP:0001278)3.18309869
31Double outlet right ventricle (HP:0001719)3.17919288
32Congenital malformation of the right heart (HP:0011723)3.17919288
33Abnormality of the renal cortex (HP:0011035)3.15434257
34Adactyly (HP:0009776)3.14448411
35Atonic seizures (HP:0010819)3.10459329
36Congenital stationary night blindness (HP:0007642)3.07193604
37Amblyopia (HP:0000646)3.00943826
38Aplasia/hypoplasia of the humerus (HP:0006507)3.00020600
39Mesomelia (HP:0003027)2.96399253
40Aplasia/Hypoplasia of the fibula (HP:0006492)2.94982061
41Abnormality of the renal medulla (HP:0100957)2.94710402
42Abnormality of the pulmonary veins (HP:0011718)2.91908176
43Abnormality of the middle phalanges of the toes (HP:0010183)2.88170542
44Short phalanx of the thumb (HP:0009660)2.84786743
45Polyuria (HP:0000103)2.83492571
46Aplasia/Hypoplasia of the spleen (HP:0010451)2.78639824
47Malignant hyperthermia (HP:0002047)2.76755210
48Inability to walk (HP:0002540)2.74965530
49Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.71141275
50Volvulus (HP:0002580)2.59524547
51Preauricular pit (HP:0004467)2.58247495
52Periauricular skin pits (HP:0100277)2.58247495
53Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.57782746
54Absent epiphyses (HP:0010577)2.57782746
55Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.56208064
56Short humerus (HP:0005792)2.54810236
57Asplenia (HP:0001746)2.48056426
58Heterochromia iridis (HP:0001100)2.43951077
59Pancreatic cysts (HP:0001737)2.43351579
60Tubulointerstitial fibrosis (HP:0005576)2.39993935
61Renal dysplasia (HP:0000110)2.39933468
62Enlarged epiphyses (HP:0010580)2.38210279
63Abnormality of the phalanges of the 5th finger (HP:0004213)2.38129747
64Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.37861753
65Deformed tarsal bones (HP:0008119)2.34356194
66Abnormal urine output (HP:0012590)2.29976711
67Broad hallux (HP:0010055)2.27272674
68Patchy hypopigmentation of hair (HP:0011365)2.23705682
69Aplasia/Hypoplasia of the sternum (HP:0006714)2.22324222
70Severe muscular hypotonia (HP:0006829)2.20649094
71Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.18299243
72Hyponatremia (HP:0002902)2.18016350
73Radial bowing (HP:0002986)2.16008529
74Symphalangism affecting the phalanges of the hand (HP:0009773)2.15585250
75Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.12428004
76Abnormal lung lobation (HP:0002101)2.09908472
77Broad toe (HP:0001837)2.09566794
78Tubulointerstitial abnormality (HP:0001969)2.09483524
79Abnormal hair whorl (HP:0010721)2.09172790
80Cerebellar dysplasia (HP:0007033)2.08063730
81Stage 5 chronic kidney disease (HP:0003774)2.05309490
82Aplasia/hypoplasia of the femur (HP:0005613)2.02167941
83True hermaphroditism (HP:0010459)2.01820168
84Abnormality of the peritoneum (HP:0002585)2.01586966
85Abnormality of the 2nd finger (HP:0004100)1.98150313
86Abnormal rod and cone electroretinograms (HP:0008323)1.97713635
873-Methylglutaconic aciduria (HP:0003535)1.92821415
88Dyskinesia (HP:0100660)1.91271519
89Congenital hepatic fibrosis (HP:0002612)1.90544127
90White forelock (HP:0002211)1.87484266
91Abnormality of renal excretion (HP:0011036)1.86717792
92Hypoproteinemia (HP:0003075)1.85360730
93Glomerulosclerosis (HP:0000096)1.83538907
94Abnormality of the anterior horn cell (HP:0006802)1.76816551
95Degeneration of anterior horn cells (HP:0002398)1.76816551
96Leukodystrophy (HP:0002415)1.72520337
97Prolonged neonatal jaundice (HP:0006579)1.72505370
98Aplasia/Hypoplasia of the ulna (HP:0006495)1.70338407
99Loss of speech (HP:0002371)1.70058674
100Aplasia/Hypoplasia of the patella (HP:0006498)1.69911772

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK397.12276857
2WNK46.95285396
3PRKD33.71854137
4RIPK13.14608656
5WNK32.98015960
6CASK2.95515499
7LMTK22.89995970
8FGR2.72757579
9EPHA42.64119953
10JAK32.47631940
11SRPK12.25236912
12EPHA32.20770226
13WNK12.15846624
14IRAK11.85382396
15TNIK1.79802519
16FER1.68485671
17YES11.64007454
18DYRK31.62244153
19PLK21.58827114
20PRKCQ1.55075008
21PHKG21.30722875
22PHKG11.30722875
23NLK1.27952460
24PDK21.27265543
25DYRK1A1.24818808
26GRK11.23153628
27FRK1.09283799
28RPS6KA51.05290913
29ADRBK21.00752781
30MAP3K130.89301620
31STK38L0.87693314
32IRAK40.87295428
33MAP4K20.85330987
34PLK30.84155753
35PRKCI0.78516587
36FGFR40.77257208
37BMPR1B0.77072972
38EPHA20.76763085
39CAMK1D0.72886623
40ITK0.71356618
41CHUK0.69866658
42MAPKAPK20.66394115
43ADRBK10.63977792
44NUAK10.63617913
45SCYL20.63057720
46MARK20.61120204
47DYRK20.59502642
48EPHB10.59233753
49TLK10.58045912
50ATR0.54220809
51DDR20.51065960
52IRAK20.49948871
53EIF2AK10.48447924
54MAPK130.46327879
55PIM20.45854361
56MKNK10.45031202
57CAMKK20.43521952
58DAPK20.43293560
59BRD40.43057606
60PRKCE0.42510040
61BRSK20.41979319
62IKBKB0.41570303
63EGFR0.37139538
64CAMK2B0.35386520
65INSRR0.34030335
66CSNK1D0.33731185
67PRKDC0.33492118
68GRK70.32043922
69MAPK150.31748880
70NTRK30.30501987
71TSSK60.30152508
72PRKACA0.30149172
73OBSCN0.29594867
74MARK30.27857461
75EPHB20.27315248
76PLK10.26147352
77PLK40.25947530
78MKNK20.25766746
79PDGFRB0.25675204
80CSNK1A10.25483185
81CAMK2A0.24461061
82RPS6KA40.24125031
83PRKG10.23674583
84PRKACB0.23101601
85PRKCA0.22034339
86GRK50.20721539
87GSK3B0.20627299
88ATM0.20401950
89MARK10.18880121
90NME20.18724475
91CAMK2G0.16945993
92TGFBR10.15395211
93CDC42BPA0.15171320
94HCK0.14834495
95MAP2K60.14787950
96MAPKAPK50.14580098
97CDK80.14509605
98IKBKE0.14440363
99CDK30.14274878
100NTRK20.13982419

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.07341897
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.48409499
3Phototransduction_Homo sapiens_hsa047442.99100282
4Fatty acid biosynthesis_Homo sapiens_hsa000612.81153069
5Steroid biosynthesis_Homo sapiens_hsa001002.78622130
6Ether lipid metabolism_Homo sapiens_hsa005652.74020278
7Collecting duct acid secretion_Homo sapiens_hsa049662.69546671
8Regulation of autophagy_Homo sapiens_hsa041402.66374252
9Fatty acid elongation_Homo sapiens_hsa000622.54258140
10Selenocompound metabolism_Homo sapiens_hsa004502.42507320
11Protein export_Homo sapiens_hsa030602.39134768
12Circadian rhythm_Homo sapiens_hsa047102.00083108
13Maturity onset diabetes of the young_Homo sapiens_hsa049501.89378418
14Fatty acid metabolism_Homo sapiens_hsa012121.88082503
15One carbon pool by folate_Homo sapiens_hsa006701.85572659
16Sphingolipid metabolism_Homo sapiens_hsa006001.69580557
17Fanconi anemia pathway_Homo sapiens_hsa034601.63879390
18Butanoate metabolism_Homo sapiens_hsa006501.62278385
19Linoleic acid metabolism_Homo sapiens_hsa005911.59173781
20Folate biosynthesis_Homo sapiens_hsa007901.57825449
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.57227689
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.55596509
23Notch signaling pathway_Homo sapiens_hsa043301.46938275
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.46665758
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.43407717
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.40701610
27Purine metabolism_Homo sapiens_hsa002301.34290753
28RNA degradation_Homo sapiens_hsa030181.34046519
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23894199
30Propanoate metabolism_Homo sapiens_hsa006401.23836955
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.23633777
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.23533729
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23230385
34Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.22008178
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.21946029
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21580829
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.19808493
38Ovarian steroidogenesis_Homo sapiens_hsa049131.16886059
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.11526507
40p53 signaling pathway_Homo sapiens_hsa041151.11498305
41Morphine addiction_Homo sapiens_hsa050321.08912922
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.08632583
43Bile secretion_Homo sapiens_hsa049761.08590853
44Pyrimidine metabolism_Homo sapiens_hsa002401.00200799
45Glutamatergic synapse_Homo sapiens_hsa047240.94584014
46PPAR signaling pathway_Homo sapiens_hsa033200.92573231
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91481411
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91061110
49Nitrogen metabolism_Homo sapiens_hsa009100.89193231
50Retinol metabolism_Homo sapiens_hsa008300.88887838
51RNA transport_Homo sapiens_hsa030130.80980026
52Oxidative phosphorylation_Homo sapiens_hsa001900.80964435
53Intestinal immune network for IgA production_Homo sapiens_hsa046720.79031493
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.76108919
55GABAergic synapse_Homo sapiens_hsa047270.74826257
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74186945
57Synaptic vesicle cycle_Homo sapiens_hsa047210.69081202
58TGF-beta signaling pathway_Homo sapiens_hsa043500.68640525
59Spliceosome_Homo sapiens_hsa030400.65412958
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65277857
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.62216028
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61758127
63RNA polymerase_Homo sapiens_hsa030200.61597118
64Arachidonic acid metabolism_Homo sapiens_hsa005900.60897180
65Metabolic pathways_Homo sapiens_hsa011000.60640332
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60109082
67Basal cell carcinoma_Homo sapiens_hsa052170.60015124
68Basal transcription factors_Homo sapiens_hsa030220.58161044
69Fat digestion and absorption_Homo sapiens_hsa049750.57786572
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57585012
71Vibrio cholerae infection_Homo sapiens_hsa051100.55841909
72N-Glycan biosynthesis_Homo sapiens_hsa005100.53585206
73Salivary secretion_Homo sapiens_hsa049700.52124843
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50934122
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50653495
76Serotonergic synapse_Homo sapiens_hsa047260.48251417
77Glycerolipid metabolism_Homo sapiens_hsa005610.47446037
78Rheumatoid arthritis_Homo sapiens_hsa053230.46170573
79beta-Alanine metabolism_Homo sapiens_hsa004100.44932562
80Gastric acid secretion_Homo sapiens_hsa049710.44510951
81Taste transduction_Homo sapiens_hsa047420.44315675
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42755421
83Phenylalanine metabolism_Homo sapiens_hsa003600.41676435
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.40172202
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40020446
86Olfactory transduction_Homo sapiens_hsa047400.39043113
87Huntingtons disease_Homo sapiens_hsa050160.38109789
88Tryptophan metabolism_Homo sapiens_hsa003800.36938471
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34287431
90Peroxisome_Homo sapiens_hsa041460.34250802
91Insulin secretion_Homo sapiens_hsa049110.33119799
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32604707
93Vitamin B6 metabolism_Homo sapiens_hsa007500.32462701
94Pyruvate metabolism_Homo sapiens_hsa006200.32434220
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.31886655
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31262722
97Fatty acid degradation_Homo sapiens_hsa000710.31188460
98Circadian entrainment_Homo sapiens_hsa047130.30196435
99Nicotine addiction_Homo sapiens_hsa050330.29361977
100Primary immunodeficiency_Homo sapiens_hsa053400.29082944

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