ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	6.32581473
2	fucose catabolic process (GO:0019317)	4.88159365
3	L-fucose metabolic process (GO:0042354)	4.88159365
4	L-fucose catabolic process (GO:0042355)	4.88159365
5	response to pheromone (GO:0019236)	4.35475357
6	water-soluble vitamin biosynthetic process (GO:0042364)	3.88907578
7	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.84835811
8	pyrimidine nucleobase catabolic process (GO:0006208)	3.66898507
9	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.59205548
10	platelet dense granule organization (GO:0060155)	3.56907489
11	negative regulation of telomere maintenance (GO:0032205)	3.55903045
12	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.49004969
13	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.49004969
14	NADH dehydrogenase complex assembly (GO:0010257)	3.49004969
15	DNA deamination (GO:0045006)	3.41690961
16	protein complex biogenesis (GO:0070271)	3.39614769
17	epithelial cilium movement (GO:0003351)	3.36858029
18	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.35819615
19	ATP synthesis coupled proton transport (GO:0015986)	3.29146341
20	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.29146341
21	kynurenine metabolic process (GO:0070189)	3.28838563
22	nucleobase catabolic process (GO:0046113)	3.26733073
23	protein neddylation (GO:0045116)	3.26153315
24	protein-cofactor linkage (GO:0018065)	3.23662681
25	cellular ketone body metabolic process (GO:0046950)	3.22366232
26	nonmotile primary cilium assembly (GO:0035058)	3.21225045
27	negative regulation of mast cell activation (GO:0033004)	3.16535379
28	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.14126856
29	indolalkylamine metabolic process (GO:0006586)	3.12977377
30	mitochondrial respiratory chain complex assembly (GO:0033108)	3.12550734
31	neuronal action potential (GO:0019228)	3.12063426
32	indole-containing compound catabolic process (GO:0042436)	3.10768514
33	indolalkylamine catabolic process (GO:0046218)	3.10768514
34	tryptophan catabolic process (GO:0006569)	3.10768514
35	regulation of action potential (GO:0098900)	3.09150190
36	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.06219129
37	piRNA metabolic process (GO:0034587)	3.04908043
38	protein localization to cilium (GO:0061512)	2.97281280
39	nephron tubule morphogenesis (GO:0072078)	2.96471113
40	nephron epithelium morphogenesis (GO:0072088)	2.96471113
41	synaptic transmission, cholinergic (GO:0007271)	2.94389109
42	detection of light stimulus involved in visual perception (GO:0050908)	2.87831122
43	detection of light stimulus involved in sensory perception (GO:0050962)	2.87831122
44	respiratory chain complex IV assembly (GO:0008535)	2.84862420
45	ketone body metabolic process (GO:1902224)	2.84628616
46	regulation of cilium movement (GO:0003352)	2.83690640
47	fucosylation (GO:0036065)	2.80613904
48	sulfation (GO:0051923)	2.77858812
49	electron transport chain (GO:0022900)	2.74990555
50	preassembly of GPI anchor in ER membrane (GO:0016254)	2.74495974
51	behavioral response to ethanol (GO:0048149)	2.72570090
52	gamma-aminobutyric acid transport (GO:0015812)	2.72264289
53	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.70410724
54	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.70410724
55	cilium morphogenesis (GO:0060271)	2.68278633
56	positive regulation of fatty acid transport (GO:2000193)	2.67820642
57	kidney morphogenesis (GO:0060993)	2.65588331
58	respiratory electron transport chain (GO:0022904)	2.64436002
59	cilium movement (GO:0003341)	2.62851007
60	amine catabolic process (GO:0009310)	2.62593118
61	cellular biogenic amine catabolic process (GO:0042402)	2.62593118
62	neural tube formation (GO:0001841)	2.57172277
63	transmission of nerve impulse (GO:0019226)	2.56846393
64	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.56735539
65	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.56303605
66	positive regulation of prostaglandin secretion (GO:0032308)	2.55732662
67	tryptophan metabolic process (GO:0006568)	2.55013455
68	regulation of hexokinase activity (GO:1903299)	2.54848709
69	regulation of glucokinase activity (GO:0033131)	2.54848709
70	hydrogen ion transmembrane transport (GO:1902600)	2.54755716
71	protein polyglutamylation (GO:0018095)	2.53327031
72	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.52257711
73	reflex (GO:0060004)	2.52052156
74	startle response (GO:0001964)	2.50670506
75	proton transport (GO:0015992)	2.50481392
76	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.49501197
77	axoneme assembly (GO:0035082)	2.48764771
78	ubiquinone biosynthetic process (GO:0006744)	2.48307288
79	postsynaptic membrane organization (GO:0001941)	2.47397313
80	cytochrome complex assembly (GO:0017004)	2.46593895
81	protein localization to synapse (GO:0035418)	2.46054077
82	indole-containing compound metabolic process (GO:0042430)	2.45793583
83	hydrogen transport (GO:0006818)	2.44351232
84	neuron fate determination (GO:0048664)	2.43821807
85	cilium organization (GO:0044782)	2.43204156
86	rRNA catabolic process (GO:0016075)	2.42924207
87	cell proliferation in forebrain (GO:0021846)	2.41359635
88	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.40545088
89	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.40503056
90	primary amino compound metabolic process (GO:1901160)	2.39931500
91	glycerophospholipid catabolic process (GO:0046475)	2.38371461
92	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.37933011
93	somite rostral/caudal axis specification (GO:0032525)	2.37640770
94	multicellular organism reproduction (GO:0032504)	2.37608089
95	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.37444522
96	regulation of telomere maintenance (GO:0032204)	2.36872516
97	cilium assembly (GO:0042384)	2.35609662
98	dopamine transport (GO:0015872)	2.34695909
99	regulation of microtubule-based movement (GO:0060632)	2.34213143
100	smoothened signaling pathway (GO:0007224)	2.32061331

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.78366713
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.64036294
3	VDR_22108803_ChIP-Seq_LS180_Human	3.25547423
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.79509677
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.63328527
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.47550664
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.44480994
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.27089615
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.26191068
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.14318492
11	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.08516798
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.07743443
13	IGF1R_20145208_ChIP-Seq_DFB_Human	2.07347703
14	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.99131690
15	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.99112599
16	FUS_26573619_Chip-Seq_HEK293_Human	1.94079591
17	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.93561933
18	EWS_26573619_Chip-Seq_HEK293_Human	1.92177994
19	P300_19829295_ChIP-Seq_ESCs_Human	1.84372675
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.80719508
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.80551907
22	TAF15_26573619_Chip-Seq_HEK293_Human	1.79840097
23	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.77875685
24	IRF1_19129219_ChIP-ChIP_H3396_Human	1.74764179
25	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.73925942
26	REST_21632747_ChIP-Seq_MESCs_Mouse	1.71829160
27	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.69088275
28	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.66222150
29	ER_23166858_ChIP-Seq_MCF-7_Human	1.62272862
30	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.61237915
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.58261051
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.57563360
33	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.54083403
34	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.54013569
35	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.53854593
36	MYC_18940864_ChIP-ChIP_HL60_Human	1.41241040
37	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.38390013
38	AR_25329375_ChIP-Seq_VCAP_Human	1.37231812
39	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.36509657
40	CBP_20019798_ChIP-Seq_JUKART_Human	1.35461251
41	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.35461251
42	RNF2_27304074_Chip-Seq_NSC_Mouse	1.35458428
43	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.34414020
44	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.34414020
45	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.33549701
46	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.32374268
47	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.31718806
48	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.31227728
49	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.31227728
50	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.30846103
51	NANOG_19829295_ChIP-Seq_ESCs_Human	1.28729968
52	SOX2_19829295_ChIP-Seq_ESCs_Human	1.28729968
53	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.28088664
54	STAT3_23295773_ChIP-Seq_U87_Human	1.27742441
55	SMAD4_21799915_ChIP-Seq_A2780_Human	1.26728080
56	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.25808294
57	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.24421244
58	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.24063889
59	NCOR_22424771_ChIP-Seq_293T_Human	1.23346177
60	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.23259663
61	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.22340254
62	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.21518132
63	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.21314981
64	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.20277452
65	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.20253967
66	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.20246186
67	TCF4_23295773_ChIP-Seq_U87_Human	1.20042207
68	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.19912171
69	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.18786937
70	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.18033655
71	TCF4_22108803_ChIP-Seq_LS180_Human	1.17133093
72	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.17070054
73	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.16713829
74	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.16360362
75	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.16325943
76	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.15976188
77	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.13003818
78	ELK1_19687146_ChIP-ChIP_HELA_Human	1.11355907
79	RUNX2_22187159_ChIP-Seq_PCA_Human	1.08984692
80	AR_20517297_ChIP-Seq_VCAP_Human	1.08195513
81	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.07770526
82	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.06963347
83	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.06827147
84	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.06550166
85	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.05521554
86	VDR_23849224_ChIP-Seq_CD4+_Human	1.05183534
87	HOXB7_26014856_ChIP-Seq_BT474_Human	1.04709057
88	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.04599151
89	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.03631041
90	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.03170457
91	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.02930124
92	TAF2_19829295_ChIP-Seq_ESCs_Human	1.02638710
93	ERA_21632823_ChIP-Seq_H3396_Human	1.02198421
94	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.00492150
95	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.96787325
96	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.96670655
97	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.96470894
98	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.96211214
99	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.95447918
100	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.95174270

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	2.96477227
2	MP0003195_calcinosis	2.61664172
3	MP0004885_abnormal_endolymph	2.49814871
4	MP0001968_abnormal_touch/_nociception	2.41685274
5	MP0004142_abnormal_muscle_tone	2.37818561
6	MP0003136_yellow_coat_color	2.32348277
7	MP0002653_abnormal_ependyma_morphology	2.25863701
8	MP0003011_delayed_dark_adaptation	2.15387093
9	MP0009745_abnormal_behavioral_response	2.15183702
10	MP0000569_abnormal_digit_pigmentation	2.15101772
11	MP0005551_abnormal_eye_electrophysiolog	2.14730808
12	MP0002736_abnormal_nociception_after	2.02003884
13	MP0006292_abnormal_olfactory_placode	1.98084707
14	MP0004742_abnormal_vestibular_system	1.94315137
15	MP0006072_abnormal_retinal_apoptosis	1.92943943
16	MP0002272_abnormal_nervous_system	1.91258146
17	MP0003880_abnormal_central_pattern	1.86683589
18	MP0002938_white_spotting	1.86394719
19	MP0002102_abnormal_ear_morphology	1.85517369
20	MP0008872_abnormal_physiological_respon	1.84208066
21	MP0004133_heterotaxia	1.82692743
22	MP0002876_abnormal_thyroid_physiology	1.82448535
23	MP0001485_abnormal_pinna_reflex	1.82310393
24	MP0009046_muscle_twitch	1.82262636
25	MP0002837_dystrophic_cardiac_calcinosis	1.81552901
26	MP0001984_abnormal_olfaction	1.81173355
27	MP0006276_abnormal_autonomic_nervous	1.79186436
28	MP0001986_abnormal_taste_sensitivity	1.75404078
29	MP0005646_abnormal_pituitary_gland	1.73121568
30	MP0003122_maternal_imprinting	1.67980310
31	MP0001486_abnormal_startle_reflex	1.66408011
32	MP0003787_abnormal_imprinting	1.66132222
33	MP0004147_increased_porphyrin_level	1.64083564
34	MP0005084_abnormal_gallbladder_morpholo	1.62351406
35	MP0008875_abnormal_xenobiotic_pharmacok	1.59367368
36	MP0002064_seizures	1.58415450
37	MP0001501_abnormal_sleep_pattern	1.57364240
38	MP0002735_abnormal_chemical_nociception	1.53562815
39	MP0002638_abnormal_pupillary_reflex	1.52152616
40	MP0005253_abnormal_eye_physiology	1.51766312
41	MP0005645_abnormal_hypothalamus_physiol	1.50498674
42	MP0002733_abnormal_thermal_nociception	1.50493498
43	MP0004145_abnormal_muscle_electrophysio	1.48738775
44	MP0003878_abnormal_ear_physiology	1.47834275
45	MP0005377_hearing/vestibular/ear_phenot	1.47834275
46	MP0002572_abnormal_emotion/affect_behav	1.45635476
47	MP0005174_abnormal_tail_pigmentation	1.42885365
48	MP0000427_abnormal_hair_cycle	1.42528252
49	MP0001970_abnormal_pain_threshold	1.41723567
50	MP0004043_abnormal_pH_regulation	1.39222858
51	MP0000631_abnormal_neuroendocrine_gland	1.38335765
52	MP0001529_abnormal_vocalization	1.35693127
53	MP0003646_muscle_fatigue	1.35657479
54	MP0000372_irregular_coat_pigmentation	1.34623480
55	MP0002557_abnormal_social/conspecific_i	1.33628347
56	MP0003635_abnormal_synaptic_transmissio	1.27222958
57	MP0002063_abnormal_learning/memory/cond	1.26649155
58	MP0002067_abnormal_sensory_capabilities	1.25961360
59	MP0005423_abnormal_somatic_nervous	1.23756636
60	MP0003283_abnormal_digestive_organ	1.23334895
61	MP0002928_abnormal_bile_duct	1.18027030
62	MP0005389_reproductive_system_phenotype	1.17174203
63	MP0001919_abnormal_reproductive_system	1.15569099
64	MP0002734_abnormal_mechanical_nocicepti	1.14578778
65	MP0002277_abnormal_respiratory_mucosa	1.14379549
66	MP0003121_genomic_imprinting	1.10324028
67	MP0003890_abnormal_embryonic-extraembry	1.07091304
68	MP0009379_abnormal_foot_pigmentation	1.06326673
69	MP0002160_abnormal_reproductive_system	1.05132107
70	MP0000778_abnormal_nervous_system	1.04889228
71	MP0004924_abnormal_behavior	1.03031357
72	MP0005386_behavior/neurological_phenoty	1.03031357
73	MP0001905_abnormal_dopamine_level	1.01498818
74	MP0005195_abnormal_posterior_eye	1.00046908
75	MP0002163_abnormal_gland_morphology	0.99353904
76	MP0002184_abnormal_innervation	0.98744602
77	MP0000026_abnormal_inner_ear	0.98728590
78	MP0010386_abnormal_urinary_bladder	0.95151813
79	MP0003252_abnormal_bile_duct	0.95071206
80	MP0001440_abnormal_grooming_behavior	0.93912754
81	MP0002752_abnormal_somatic_nervous	0.92793998
82	MP0001963_abnormal_hearing_physiology	0.92363504
83	MP0005075_abnormal_melanosome_morpholog	0.91991673
84	MP0005379_endocrine/exocrine_gland_phen	0.90606588
85	MP0003718_maternal_effect	0.87870952
86	MP0002095_abnormal_skin_pigmentation	0.87037292
87	MP0001324_abnormal_eye_pigmentation	0.85779341
88	MP0005410_abnormal_fertilization	0.85101547
89	MP0000230_abnormal_systemic_arterial	0.83075595
90	MP0002138_abnormal_hepatobiliary_system	0.83061118
91	MP0001502_abnormal_circadian_rhythm	0.82249898
92	MP0002909_abnormal_adrenal_gland	0.81713742
93	MP0002751_abnormal_autonomic_nervous	0.81538134
94	MP0002693_abnormal_pancreas_physiology	0.80233523
95	MP0005332_abnormal_amino_acid	0.77250588
96	MP0000955_abnormal_spinal_cord	0.76707887
97	MP0002234_abnormal_pharynx_morphology	0.75610977
98	MP0002229_neurodegeneration	0.75480041
99	MP0005167_abnormal_blood-brain_barrier	0.73930739
100	MP0008789_abnormal_olfactory_epithelium	0.73620669

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of midbrain morphology (HP:0002418)	4.34611911
2	Molar tooth sign on MRI (HP:0002419)	4.34611911
3	Pancreatic cysts (HP:0001737)	4.15583824
4	Pancreatic fibrosis (HP:0100732)	3.96422428
5	True hermaphroditism (HP:0010459)	3.75009396
6	Nephronophthisis (HP:0000090)	3.67550556
7	Type II lissencephaly (HP:0007260)	3.33000289
8	Congenital stationary night blindness (HP:0007642)	3.28414570
9	Abnormality of alanine metabolism (HP:0010916)	3.09530239
10	Hyperalaninemia (HP:0003348)	3.09530239
11	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.09530239
12	Abnormality of the renal medulla (HP:0100957)	3.09169188
13	Medial flaring of the eyebrow (HP:0010747)	3.01524586
14	Abnormality of the renal cortex (HP:0011035)	3.00896456
15	Tubular atrophy (HP:0000092)	2.72388742
16	Large for gestational age (HP:0001520)	2.69076413
17	Hyperventilation (HP:0002883)	2.68909289
18	Mitochondrial inheritance (HP:0001427)	2.64961967
19	Pendular nystagmus (HP:0012043)	2.59182505
20	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.59085147
21	Absent/shortened dynein arms (HP:0200106)	2.59085147
22	Acute necrotizing encephalopathy (HP:0006965)	2.58686464
23	Polydipsia (HP:0001959)	2.58423100
24	Abnormal drinking behavior (HP:0030082)	2.58423100
25	Sclerocornea (HP:0000647)	2.56196714
26	Abolished electroretinogram (ERG) (HP:0000550)	2.56105510
27	Abnormality of the labia minora (HP:0012880)	2.55214006
28	Attenuation of retinal blood vessels (HP:0007843)	2.51802537
29	Increased CSF lactate (HP:0002490)	2.48420408
30	Gait imbalance (HP:0002141)	2.45625873
31	Congenital, generalized hypertrichosis (HP:0004540)	2.45486977
32	Cystic liver disease (HP:0006706)	2.44495719
33	Abnormal rod and cone electroretinograms (HP:0008323)	2.34904273
34	Abnormality of the pons (HP:0007361)	2.31975458
35	Congenital primary aphakia (HP:0007707)	2.31086526
36	Lissencephaly (HP:0001339)	2.30789693
37	Polyuria (HP:0000103)	2.27743971
38	Chronic hepatic failure (HP:0100626)	2.27629870
39	Progressive cerebellar ataxia (HP:0002073)	2.27010887
40	Abnormal respiratory motile cilium morphology (HP:0005938)	2.26116776
41	Abnormal respiratory epithelium morphology (HP:0012253)	2.26116776
42	Inability to walk (HP:0002540)	2.25811084
43	Hypoplasia of the pons (HP:0012110)	2.23717537
44	Progressive macrocephaly (HP:0004481)	2.22959869
45	Hepatocellular necrosis (HP:0001404)	2.22039876
46	Cerebellar dysplasia (HP:0007033)	2.21647631
47	Acute encephalopathy (HP:0006846)	2.21078694
48	Abnormal mitochondria in muscle tissue (HP:0008316)	2.20777936
49	Broad-based gait (HP:0002136)	2.20040803
50	Nephrogenic diabetes insipidus (HP:0009806)	2.18233007
51	Concave nail (HP:0001598)	2.15921505
52	Abnormal number of erythroid precursors (HP:0012131)	2.14673455
53	Renal cortical cysts (HP:0000803)	2.14303450
54	Anencephaly (HP:0002323)	2.13559492
55	Hepatic necrosis (HP:0002605)	2.13295461
56	Optic disc pallor (HP:0000543)	2.12951261
57	Focal motor seizures (HP:0011153)	2.10759873
58	Lipid accumulation in hepatocytes (HP:0006561)	2.10072967
59	Furrowed tongue (HP:0000221)	2.09433934
60	Polyphagia (HP:0002591)	2.07249934
61	Methylmalonic acidemia (HP:0002912)	2.05020915
62	Increased hepatocellular lipid droplets (HP:0006565)	2.04667359
63	Rib fusion (HP:0000902)	2.02763735
64	Pachygyria (HP:0001302)	2.01101919
65	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.99701841
66	Bile duct proliferation (HP:0001408)	1.99443547
67	Abnormal biliary tract physiology (HP:0012439)	1.99443547
68	Hypothermia (HP:0002045)	1.99097117
69	Congenital hepatic fibrosis (HP:0002612)	1.96361639
70	Keratoconus (HP:0000563)	1.95658206
71	Increased corneal curvature (HP:0100692)	1.95658206
72	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.95590848
73	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.95414745
74	3-Methylglutaconic aciduria (HP:0003535)	1.93940682
75	Oligodactyly (hands) (HP:0001180)	1.93388240
76	Abnormality of cells of the erythroid lineage (HP:0012130)	1.91350033
77	Severe muscular hypotonia (HP:0006829)	1.90197336
78	Male pseudohermaphroditism (HP:0000037)	1.89894876
79	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.88782767
80	Genital tract atresia (HP:0001827)	1.88011756
81	Agitation (HP:0000713)	1.86953098
82	Hemiparesis (HP:0001269)	1.86119470
83	Septo-optic dysplasia (HP:0100842)	1.85604000
84	Postaxial foot polydactyly (HP:0001830)	1.82594674
85	Methylmalonic aciduria (HP:0012120)	1.82467689
86	Optic nerve hypoplasia (HP:0000609)	1.82456883
87	Aplasia/hypoplasia of the uterus (HP:0008684)	1.82358303
88	Bilateral microphthalmos (HP:0007633)	1.82304413
89	Vaginal atresia (HP:0000148)	1.81933265
90	Limb dystonia (HP:0002451)	1.81710302
91	Genetic anticipation (HP:0003743)	1.79615870
92	Retinal dysplasia (HP:0007973)	1.79551691
93	Gaze-evoked nystagmus (HP:0000640)	1.78849092
94	Abnormal urine output (HP:0012590)	1.78507220
95	Stomach cancer (HP:0012126)	1.78393355
96	Congenital sensorineural hearing impairment (HP:0008527)	1.78112906
97	Progressive inability to walk (HP:0002505)	1.77209380
98	Patellar aplasia (HP:0006443)	1.76943574
99	Decreased central vision (HP:0007663)	1.76694497
100	Bony spicule pigmentary retinopathy (HP:0007737)	1.75857773

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.82073765
2	ADRBK2	3.43505499
3	WNK4	3.40754688
4	ZAK	2.84182194
5	TLK1	2.81374277
6	WNK3	2.69490114
7	BMPR1B	2.69057666
8	PINK1	2.64270867
9	GRK1	2.58783122
10	CASK	2.21651569
11	INSRR	2.09202564
12	OXSR1	2.08537423
13	PNCK	2.08140084
14	TAOK3	2.04888461
15	STK39	1.98089106
16	TXK	1.84850953
17	MAPK13	1.80819040
18	MAP4K2	1.80536788
19	MAP3K4	1.68810366
20	NUAK1	1.68450835
21	DYRK2	1.61023476
22	ACVR1B	1.53557849
23	MARK1	1.51240970
24	DAPK2	1.49028334
25	CDK19	1.42552515
26	MAPK15	1.35549354
27	PRKCG	1.28275310
28	ADRBK1	1.16711476
29	TRIM28	1.12177467
30	TGFBR1	1.09302972
31	MKNK2	1.08387389
32	CAMKK2	1.07811584
33	PAK3	1.06569264
34	PHKG2	1.03317747
35	PHKG1	1.03317747
36	MUSK	1.00648159
37	MAP2K7	1.00393675
38	TNIK	0.94042209
39	STK16	0.93217408
40	VRK1	0.92189547
41	PRKCE	0.92175665
42	BCKDK	0.87566981
43	CSNK1G1	0.86434686
44	CSNK1G2	0.85796953
45	EPHA3	0.83594219
46	PIK3CA	0.79117687
47	NTRK2	0.77938238
48	CSNK1G3	0.74587102
49	WEE1	0.70734581
50	PLK2	0.68838547
51	SIK2	0.68791363
52	TAF1	0.66536142
53	PRKCI	0.65550954
54	RPS6KA5	0.63645993
55	TIE1	0.63522449
56	MAP2K6	0.61900889
57	PRKCQ	0.61773857
58	CAMK2A	0.60598391
59	PASK	0.58781085
60	CSNK1A1L	0.58186731
61	BUB1	0.57564546
62	PLK4	0.56953183
63	EPHB2	0.55608757
64	PRKACA	0.54333378
65	CAMK1	0.53425932
66	VRK2	0.52763674
67	DYRK1A	0.52014270
68	TSSK6	0.51524885
69	TEC	0.51043446
70	KIT	0.50592460
71	IRAK1	0.49644103
72	GRK7	0.49406369
73	MST4	0.49400856
74	MAP2K2	0.48982584
75	PRKCZ	0.48432101
76	MAPKAPK5	0.48322082
77	PTK2B	0.47730744
78	WNK1	0.47310776
79	NLK	0.45962254
80	PLK3	0.45283594
81	IKBKB	0.44467342
82	PRKCA	0.43860514
83	TYRO3	0.42496313
84	CSNK1A1	0.42257856
85	NTRK3	0.41207761
86	PKN1	0.40701307
87	MKNK1	0.39681246
88	STK38L	0.39432471
89	CAMKK1	0.38763830
90	NME1	0.38725165
91	STK11	0.37985847
92	CDK8	0.37121763
93	PRKG1	0.34558739
94	BCR	0.34523542
95	CSNK1D	0.34050052
96	MINK1	0.33532213
97	OBSCN	0.33448799
98	PRKCH	0.32659038
99	ITK	0.31788046
100	CAMK2D	0.31250932

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.25228853
2	Parkinsons disease_Homo sapiens_hsa05012	2.51658588
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.41703354
4	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.39420620
5	Protein export_Homo sapiens_hsa03060	2.38813605
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.38337366
7	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.32766002
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.32053120
9	Phototransduction_Homo sapiens_hsa04744	2.29510462
10	Nicotine addiction_Homo sapiens_hsa05033	2.25174600
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.19778842
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.03100791
13	Butanoate metabolism_Homo sapiens_hsa00650	1.98569462
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.97286754
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.88078299
16	RNA polymerase_Homo sapiens_hsa03020	1.84894890
17	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.80890439
18	Alzheimers disease_Homo sapiens_hsa05010	1.70134874
19	Ribosome_Homo sapiens_hsa03010	1.70028906
20	Cardiac muscle contraction_Homo sapiens_hsa04260	1.66851890
21	Ether lipid metabolism_Homo sapiens_hsa00565	1.66520137
22	Huntingtons disease_Homo sapiens_hsa05016	1.64575481
23	Basal transcription factors_Homo sapiens_hsa03022	1.63996914
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.62893344
25	Selenocompound metabolism_Homo sapiens_hsa00450	1.62547239
26	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.57875155
27	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.55743824
28	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.51003998
29	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.45578201
30	Caffeine metabolism_Homo sapiens_hsa00232	1.40551522
31	Proteasome_Homo sapiens_hsa03050	1.33922907
32	Taste transduction_Homo sapiens_hsa04742	1.27184372
33	Morphine addiction_Homo sapiens_hsa05032	1.26117933
34	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.25220822
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.19742941
36	Homologous recombination_Homo sapiens_hsa03440	1.19416106
37	Propanoate metabolism_Homo sapiens_hsa00640	1.17524073
38	RNA degradation_Homo sapiens_hsa03018	1.14801369
39	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.13716029
40	Olfactory transduction_Homo sapiens_hsa04740	1.12325074
41	Insulin secretion_Homo sapiens_hsa04911	1.08406783
42	Peroxisome_Homo sapiens_hsa04146	1.07276994
43	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.06408082
44	Fanconi anemia pathway_Homo sapiens_hsa03460	1.04636245
45	Chemical carcinogenesis_Homo sapiens_hsa05204	1.04570860
46	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.03126007
47	Asthma_Homo sapiens_hsa05310	1.01901624
48	Collecting duct acid secretion_Homo sapiens_hsa04966	1.01031830
49	GABAergic synapse_Homo sapiens_hsa04727	0.98242028
50	Sulfur metabolism_Homo sapiens_hsa00920	0.97978143
51	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.94791665
52	Glutamatergic synapse_Homo sapiens_hsa04724	0.92984895
53	Serotonergic synapse_Homo sapiens_hsa04726	0.90659481
54	Steroid biosynthesis_Homo sapiens_hsa00100	0.89151669
55	Fat digestion and absorption_Homo sapiens_hsa04975	0.86684057
56	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.86157254
57	Circadian entrainment_Homo sapiens_hsa04713	0.85413323
58	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.84682423
59	One carbon pool by folate_Homo sapiens_hsa00670	0.82598834
60	Retinol metabolism_Homo sapiens_hsa00830	0.82037151
61	Primary immunodeficiency_Homo sapiens_hsa05340	0.77292747
62	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.77200432
63	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.73767130
64	Sulfur relay system_Homo sapiens_hsa04122	0.72290767
65	Regulation of autophagy_Homo sapiens_hsa04140	0.71084964
66	beta-Alanine metabolism_Homo sapiens_hsa00410	0.69792483
67	Type I diabetes mellitus_Homo sapiens_hsa04940	0.68698284
68	ABC transporters_Homo sapiens_hsa02010	0.67550447
69	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.64632158
70	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.64179701
71	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.64102106
72	Metabolic pathways_Homo sapiens_hsa01100	0.63355407
73	Histidine metabolism_Homo sapiens_hsa00340	0.63268294
74	Purine metabolism_Homo sapiens_hsa00230	0.62355591
75	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.61502853
76	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.61384400
77	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.59759230
78	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.59740178
79	Allograft rejection_Homo sapiens_hsa05330	0.54398332
80	Pyrimidine metabolism_Homo sapiens_hsa00240	0.53500920
81	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.53196831
82	Mineral absorption_Homo sapiens_hsa04978	0.51504362
83	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.51276486
84	Rheumatoid arthritis_Homo sapiens_hsa05323	0.48902089
85	Cocaine addiction_Homo sapiens_hsa05030	0.48677096
86	Graft-versus-host disease_Homo sapiens_hsa05332	0.48464389
87	Dopaminergic synapse_Homo sapiens_hsa04728	0.47442494
88	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.46883730
89	Calcium signaling pathway_Homo sapiens_hsa04020	0.46703060
90	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.41317593
91	Circadian rhythm_Homo sapiens_hsa04710	0.39516666
92	Glycerolipid metabolism_Homo sapiens_hsa00561	0.39489005
93	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.38574180
94	Basal cell carcinoma_Homo sapiens_hsa05217	0.36780879
95	Fatty acid degradation_Homo sapiens_hsa00071	0.36318945
96	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.35691273
97	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.35498382
98	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.35136818
99	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.34421529
100	Amphetamine addiction_Homo sapiens_hsa05031	0.34263127

ZNF90P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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