ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synapsis (GO:0007129)	5.89175507
2	regulation of meiosis I (GO:0060631)	5.86835088
3	piRNA metabolic process (GO:0034587)	4.91774181
4	male meiosis I (GO:0007141)	4.65823598
5	DNA double-strand break processing (GO:0000729)	4.46773743
6	chromatin remodeling at centromere (GO:0031055)	4.42880055
7	CENP-A containing nucleosome assembly (GO:0034080)	4.35680392
8	male meiosis (GO:0007140)	4.33208571
9	mitotic metaphase plate congression (GO:0007080)	4.25758491
10	chromosome organization involved in meiosis (GO:0070192)	4.25083996
11	meiotic chromosome segregation (GO:0045132)	4.23918731
12	meiotic nuclear division (GO:0007126)	3.92440304
13	histone exchange (GO:0043486)	3.85092954
14	DNA synthesis involved in DNA repair (GO:0000731)	3.82628665
15	meiosis I (GO:0007127)	3.81680176
16	DNA replication checkpoint (GO:0000076)	3.81028878
17	histone H2A acetylation (GO:0043968)	3.72623164
18	mitotic sister chromatid cohesion (GO:0007064)	3.69092928
19	DNA catabolic process, exonucleolytic (GO:0000738)	3.66250058
20	metaphase plate congression (GO:0051310)	3.63678740
21	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.62835733
22	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.62835733
23	postreplication repair (GO:0006301)	3.59308907
24	DNA replication-independent nucleosome assembly (GO:0006336)	3.58166539
25	DNA replication-independent nucleosome organization (GO:0034724)	3.58166539
26	DNA methylation involved in gamete generation (GO:0043046)	3.53457296
27	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.53364981
28	mitotic spindle checkpoint (GO:0071174)	3.50363471
29	sister chromatid cohesion (GO:0007062)	3.49087088
30	negative regulation of gene silencing (GO:0060969)	3.48196459
31	kinetochore organization (GO:0051383)	3.46285664
32	negative regulation of mitotic sister chromatid separation (GO:2000816)	3.43151313
33	negative regulation of sister chromatid segregation (GO:0033046)	3.43151313
34	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	3.43151313
35	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	3.43151313
36	negative regulation of mitotic sister chromatid segregation (GO:0033048)	3.43151313
37	negative regulation of chromosome segregation (GO:0051985)	3.43072923
38	spindle checkpoint (GO:0031577)	3.39862166
39	resolution of meiotic recombination intermediates (GO:0000712)	3.37550245
40	nuclear pore organization (GO:0006999)	3.36511105
41	regulation of mitotic metaphase/anaphase transition (GO:0030071)	3.34580029
42	regulation of metaphase/anaphase transition of cell cycle (GO:1902099)	3.34580029
43	DNA replication-dependent nucleosome organization (GO:0034723)	3.32250655
44	DNA replication-dependent nucleosome assembly (GO:0006335)	3.32250655
45	IMP biosynthetic process (GO:0006188)	3.32056092
46	mitotic spindle assembly checkpoint (GO:0007094)	3.31626801
47	meiotic cell cycle process (GO:1903046)	3.30208519
48	spindle assembly checkpoint (GO:0071173)	3.30028422
49	regulation of sister chromatid segregation (GO:0033045)	3.26617500
50	regulation of mitotic sister chromatid separation (GO:0010965)	3.26617500
51	regulation of mitotic sister chromatid segregation (GO:0033047)	3.26617500
52	protein K11-linked ubiquitination (GO:0070979)	3.20319232
53	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.17592105
54	nuclear pore complex assembly (GO:0051292)	3.12851456
55	purine nucleobase biosynthetic process (GO:0009113)	3.11699751
56	mismatch repair (GO:0006298)	3.10748501
57	positive regulation of meiosis (GO:0045836)	3.08861646
58	telomere maintenance via semi-conservative replication (GO:0032201)	3.08849986
59	synaptonemal complex organization (GO:0070193)	3.04891377
60	protein localization to kinetochore (GO:0034501)	3.04030239
61	kinetochore assembly (GO:0051382)	3.03322497
62	regulation of transcription from RNA polymerase I promoter (GO:0006356)	3.02650196
63	regulation of centriole replication (GO:0046599)	3.02001982
64	DNA strand elongation involved in DNA replication (GO:0006271)	2.97341479
65	regulation of chromatin silencing (GO:0031935)	2.96722669
66	positive regulation of meiotic cell cycle (GO:0051446)	2.96164030
67	negative regulation of meiosis (GO:0045835)	2.95517770
68	regulation of chromosome segregation (GO:0051983)	2.95494057
69	proteasome assembly (GO:0043248)	2.95174774
70	negative regulation of mitosis (GO:0045839)	2.89445736
71	protein K6-linked ubiquitination (GO:0085020)	2.89001827
72	gene silencing by RNA (GO:0031047)	2.88960548
73	synaptonemal complex assembly (GO:0007130)	2.88555307
74	translesion synthesis (GO:0019985)	2.88437376
75	negative regulation of nuclear division (GO:0051784)	2.88080056
76	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.87251146
77	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.87251146
78	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.87251146
79	cholesterol biosynthetic process (GO:0006695)	2.85805855
80	DNA strand elongation (GO:0022616)	2.85560260
81	intra-S DNA damage checkpoint (GO:0031573)	2.85546695
82	attachment of spindle microtubules to kinetochore (GO:0008608)	2.84790830
83	mitotic spindle organization (GO:0007052)	2.81462446
84	microtubule depolymerization (GO:0007019)	2.80974946
85	DNA ligation (GO:0006266)	2.80716473
86	centriole replication (GO:0007099)	2.80051358
87	nucleobase biosynthetic process (GO:0046112)	2.79831089
88	reciprocal meiotic recombination (GO:0007131)	2.78462034
89	reciprocal DNA recombination (GO:0035825)	2.78462034
90	histone H3-K36 demethylation (GO:0070544)	2.78157397
91	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.77463474
92	mitotic chromosome condensation (GO:0007076)	2.76005986
93	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.75711414
94	establishment of chromosome localization (GO:0051303)	2.75586879
95	protein neddylation (GO:0045116)	2.74877361
96	mitotic recombination (GO:0006312)	2.74431092
97	IMP metabolic process (GO:0046040)	2.73986115
98	regulation of histone H3-K9 methylation (GO:0051570)	2.73693620
99	regulation of DNA endoreduplication (GO:0032875)	2.71717947
100	apical protein localization (GO:0045176)	2.70954503

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	5.30080907
2	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.86787158
3	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.68471705
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.67967433
5	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	3.14645428
6	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.97192107
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.73768746
8	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.63863019
9	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.48653941
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.43506609
11	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.41668192
12	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.37419688
13	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.32357452
14	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.32077374
15	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.17623827
16	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.09013631
17	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.03915711
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.01283378
19	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.99283155
20	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.97103805
21	AR_21909140_ChIP-Seq_LNCAP_Human	1.91617634
22	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.91514553
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.90671550
24	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.90175508
25	FUS_26573619_Chip-Seq_HEK293_Human	1.90063435
26	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.86272128
27	ELK1_19687146_ChIP-ChIP_HELA_Human	1.85989194
28	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.83481822
29	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.80309838
30	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.77496955
31	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.73892400
32	EWS_26573619_Chip-Seq_HEK293_Human	1.69131196
33	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.65045551
34	TAF15_26573619_Chip-Seq_HEK293_Human	1.58588395
35	VDR_23849224_ChIP-Seq_CD4+_Human	1.57264120
36	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.56578033
37	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.50588016
38	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.49282695
39	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.48676782
40	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.45936674
41	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.45392507
42	P300_19829295_ChIP-Seq_ESCs_Human	1.42088956
43	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.39136595
44	FOXP3_21729870_ChIP-Seq_TREG_Human	1.38943189
45	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.37576919
46	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.32651681
47	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.31887650
48	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.30242255
49	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.29391947
50	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.28331632
51	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.25708501
52	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.25662647
53	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.22291333
54	IRF1_19129219_ChIP-ChIP_H3396_Human	1.21612783
55	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.20706272
56	MYC_18940864_ChIP-ChIP_HL60_Human	1.20243791
57	VDR_22108803_ChIP-Seq_LS180_Human	1.20210009
58	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.19427330
59	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.18500019
60	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.18456054
61	GBX2_23144817_ChIP-Seq_PC3_Human	1.17440975
62	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.16673828
63	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.16586479
64	GABP_19822575_ChIP-Seq_HepG2_Human	1.16497526
65	DCP1A_22483619_ChIP-Seq_HELA_Human	1.15732995
66	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.15266591
67	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.14638611
68	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.13620580
69	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.12807723
70	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.12694781
71	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.12451940
72	BCAT_22108803_ChIP-Seq_LS180_Human	1.12184654
73	TTF2_22483619_ChIP-Seq_HELA_Human	1.10104576
74	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.06855398
75	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.06580555
76	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.05092755
77	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.03312690
78	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.01548713
79	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.00854811
80	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.00302846
81	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.00302846
82	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.00302846
83	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.00211986
84	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.99924984
85	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.99183901
86	RNF2_27304074_Chip-Seq_NSC_Mouse	0.98988710
87	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.98842038
88	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.96653068
89	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.96468690
90	SALL4_18804426_ChIP-ChIP_MESCs_Mouse	0.95833816
91	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.95806140
92	ER_23166858_ChIP-Seq_MCF-7_Human	0.94837786
93	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.94593439
94	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.92479599
95	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.92383886
96	RUNX2_22187159_ChIP-Seq_PCA_Human	0.92379644
97	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.91541561
98	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.90992925
99	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.90364883
100	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.90200563

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	5.17845724
2	MP0008058_abnormal_DNA_repair	3.54835360
3	MP0003890_abnormal_embryonic-extraembry	3.40573458
4	MP0010094_abnormal_chromosome_stability	3.30287364
5	MP0008057_abnormal_DNA_replication	3.18268188
6	MP0003693_abnormal_embryo_hatching	2.96579719
7	MP0004957_abnormal_blastocyst_morpholog	2.59851919
8	MP0002102_abnormal_ear_morphology	2.38806327
9	MP0003111_abnormal_nucleus_morphology	2.37690824
10	MP0003077_abnormal_cell_cycle	2.21338745
11	MP0008932_abnormal_embryonic_tissue	2.16606108
12	MP0003787_abnormal_imprinting	2.11271593
13	MP0003718_maternal_effect	1.95393639
14	MP0008789_abnormal_olfactory_epithelium	1.87825237
15	MP0003567_abnormal_fetal_cardiomyocyte	1.80455166
16	MP0003937_abnormal_limbs/digits/tail_de	1.78696069
17	MP0002210_abnormal_sex_determination	1.78157749
18	MP0005499_abnormal_olfactory_system	1.73569029
19	MP0005394_taste/olfaction_phenotype	1.73569029
20	MP0002822_catalepsy	1.67436076
21	MP0003121_genomic_imprinting	1.67158502
22	MP0006292_abnormal_olfactory_placode	1.66922863
23	MP0001929_abnormal_gametogenesis	1.66509680
24	MP0001188_hyperpigmentation	1.66035624
25	MP0003195_calcinosis	1.65850434
26	MP0000383_abnormal_hair_follicle	1.65580566
27	MP0003283_abnormal_digestive_organ	1.57137654
28	MP0003119_abnormal_digestive_system	1.54051790
29	MP0002837_dystrophic_cardiac_calcinosis	1.53441791
30	MP0001145_abnormal_male_reproductive	1.47738096
31	MP0006035_abnormal_mitochondrial_morpho	1.47379269
32	MP0002084_abnormal_developmental_patter	1.45757142
33	MP0001730_embryonic_growth_arrest	1.44533018
34	MP0003123_paternal_imprinting	1.39361387
35	MP0000653_abnormal_sex_gland	1.38747097
36	MP0001293_anophthalmia	1.35228631
37	MP0000427_abnormal_hair_cycle	1.32749932
38	MP0003698_abnormal_male_reproductive	1.32673356
39	MP0010678_abnormal_skin_adnexa	1.30625180
40	MP0002254_reproductive_system_inflammat	1.25257686
41	MP0002233_abnormal_nose_morphology	1.24577091
42	MP0001529_abnormal_vocalization	1.24471863
43	MP0009697_abnormal_copulation	1.24394240
44	MP0000778_abnormal_nervous_system	1.23941072
45	MP0002160_abnormal_reproductive_system	1.20650500
46	MP0001697_abnormal_embryo_size	1.20383264
47	MP0001672_abnormal_embryogenesis/_devel	1.17756698
48	MP0005380_embryogenesis_phenotype	1.17756698
49	MP0009672_abnormal_birth_weight	1.17451017
50	MP0001177_atelectasis	1.17379803
51	MP0005645_abnormal_hypothalamus_physiol	1.16461457
52	MP0000631_abnormal_neuroendocrine_gland	1.16252119
53	MP0003943_abnormal_hepatobiliary_system	1.15876858
54	MP0010307_abnormal_tumor_latency	1.12639261
55	MP0001764_abnormal_homeostasis	1.12586654
56	MP0002085_abnormal_embryonic_tissue	1.09878371
57	MP0003122_maternal_imprinting	1.09153679
58	MP0000647_abnormal_sebaceous_gland	1.06211877
59	MP0009703_decreased_birth_body	1.05868115
60	MP0003941_abnormal_skin_development	1.05671415
61	MP0006072_abnormal_retinal_apoptosis	1.04432588
62	MP0000350_abnormal_cell_proliferation	1.02513124
63	MP0008007_abnormal_cellular_replicative	0.99476784
64	MP0002909_abnormal_adrenal_gland	0.98514328
65	MP0004147_increased_porphyrin_level	0.97600696
66	MP0004197_abnormal_fetal_growth/weight/	0.97527081
67	MP0004133_heterotaxia	0.97249127
68	MP0008004_abnormal_stomach_pH	0.96439693
69	MP0005646_abnormal_pituitary_gland	0.93369838
70	MP0003880_abnormal_central_pattern	0.92558560
71	MP0002735_abnormal_chemical_nociception	0.91321439
72	MP0003186_abnormal_redox_activity	0.90563240
73	MP0000639_abnormal_adrenal_gland	0.90039110
74	MP0003861_abnormal_nervous_system	0.89582377
75	MP0003984_embryonic_growth_retardation	0.88485122
76	MP0008995_early_reproductive_senescence	0.88370690
77	MP0005253_abnormal_eye_physiology	0.87779814
78	MP0002088_abnormal_embryonic_growth/wei	0.87428557
79	MP0006054_spinal_hemorrhage	0.87151402
80	MP0000358_abnormal_cell_content/	0.87024141
81	MP0002751_abnormal_autonomic_nervous	0.83882805
82	MP0003786_premature_aging	0.82638484
83	MP0002161_abnormal_fertility/fecundity	0.82264906
84	MP0005075_abnormal_melanosome_morpholog	0.81870038
85	MP0000462_abnormal_digestive_system	0.81762605
86	MP0002080_prenatal_lethality	0.80750014
87	MP0001119_abnormal_female_reproductive	0.79939913
88	MP0001984_abnormal_olfaction	0.76618440
89	MP0006036_abnormal_mitochondrial_physio	0.76407656
90	MP0005220_abnormal_exocrine_pancreas	0.75463252
91	MP0002734_abnormal_mechanical_nocicepti	0.73901302
92	MP0002736_abnormal_nociception_after	0.73156670
93	MP0004215_abnormal_myocardial_fiber	0.70287193
94	MP0003938_abnormal_ear_development	0.70268490
95	MP0002086_abnormal_extraembryonic_tissu	0.70231410
96	MP0010030_abnormal_orbit_morphology	0.70194864
97	MP0005389_reproductive_system_phenotype	0.69683303
98	MP0002009_preneoplasia	0.68445344
99	MP0002111_abnormal_tail_morphology	0.67471653
100	MP0005551_abnormal_eye_electrophysiolog	0.67147841

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the lower motor neuron (HP:0002366)	4.97893883
2	Amyotrophic lateral sclerosis (HP:0007354)	4.80248675
3	Abnormality of the labia minora (HP:0012880)	3.84382735
4	Hyperglycinemia (HP:0002154)	3.18630899
5	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.12953511
6	Chromsome breakage (HP:0040012)	3.04941670
7	Atrophy/Degeneration involving motor neurons (HP:0007373)	3.02457078
8	Volvulus (HP:0002580)	2.95177759
9	Abnormal lung lobation (HP:0002101)	2.92332048
10	Gonadotropin excess (HP:0000837)	2.87960914
11	Methylmalonic acidemia (HP:0002912)	2.80625507
12	Shoulder girdle muscle weakness (HP:0003547)	2.77658303
13	Rhabdomyosarcoma (HP:0002859)	2.75124772
14	Nephroblastoma (Wilms tumor) (HP:0002667)	2.68260253
15	Embryonal renal neoplasm (HP:0011794)	2.57186417
16	Abnormality of chromosome stability (HP:0003220)	2.54962516
17	Tetraparesis (HP:0002273)	2.52941449
18	Colon cancer (HP:0003003)	2.51848611
19	Meckel diverticulum (HP:0002245)	2.42468189
20	Abnormality of the ileum (HP:0001549)	2.38701786
21	Intellectual disability, moderate (HP:0002342)	2.35696883
22	Impaired vibration sensation in the lower limbs (HP:0002166)	2.34459942
23	Type I transferrin isoform profile (HP:0003642)	2.34094692
24	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.31386142
25	Supernumerary spleens (HP:0009799)	2.28479755
26	Carpal bone hypoplasia (HP:0001498)	2.28041101
27	Horizontal nystagmus (HP:0000666)	2.27202970
28	Papillary thyroid carcinoma (HP:0002895)	2.26593060
29	Cortical dysplasia (HP:0002539)	2.25551631
30	Facial hemangioma (HP:0000329)	2.25484751
31	Meningioma (HP:0002858)	2.24216951
32	Abnormality of the corticospinal tract (HP:0002492)	2.23720734
33	Nephronophthisis (HP:0000090)	2.22619753
34	Abnormality of serine family amino acid metabolism (HP:0010894)	2.20787884
35	Abnormality of glycine metabolism (HP:0010895)	2.20787884
36	Ectopic kidney (HP:0000086)	2.17024527
37	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.14336515
38	Abnormal protein N-linked glycosylation (HP:0012347)	2.14336515
39	Abnormal protein glycosylation (HP:0012346)	2.14336515
40	Abnormal glycosylation (HP:0012345)	2.14336515
41	Hyperglycinuria (HP:0003108)	2.14057504
42	Abnormality of abdominal situs (HP:0011620)	2.13529447
43	Abdominal situs inversus (HP:0003363)	2.13529447
44	Small intestinal stenosis (HP:0012848)	2.11535720
45	Duodenal stenosis (HP:0100867)	2.11535720
46	Glioma (HP:0009733)	2.10768510
47	Biliary tract neoplasm (HP:0100574)	2.09158599
48	Abnormality of midbrain morphology (HP:0002418)	2.08789993
49	Molar tooth sign on MRI (HP:0002419)	2.08789993
50	Chronic hepatic failure (HP:0100626)	2.07507347
51	Retinal dysplasia (HP:0007973)	2.06878671
52	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.06456943
53	Broad distal phalanx of finger (HP:0009836)	2.05106182
54	Breast carcinoma (HP:0003002)	2.04880042
55	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.04521555
56	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.04521555
57	Rimmed vacuoles (HP:0003805)	2.04311986
58	Cerebral hypomyelination (HP:0006808)	2.03060998
59	Ovarian neoplasm (HP:0100615)	2.02238089
60	Abnormality of the duodenum (HP:0002246)	2.00391243
61	Abnormality of the preputium (HP:0100587)	1.99362821
62	Ependymoma (HP:0002888)	1.97938699
63	Medulloblastoma (HP:0002885)	1.96749712
64	Increased nuchal translucency (HP:0010880)	1.95717295
65	Anteriorly placed anus (HP:0001545)	1.95241913
66	Horseshoe kidney (HP:0000085)	1.93673446
67	Dyskinesia (HP:0100660)	1.93437801
68	Abnormality of the astrocytes (HP:0100707)	1.92920564
69	Astrocytoma (HP:0009592)	1.92920564
70	Neuroendocrine neoplasm (HP:0100634)	1.90698869
71	Pheochromocytoma (HP:0002666)	1.89370276
72	Bifid tongue (HP:0010297)	1.88599211
73	Embryonal neoplasm (HP:0002898)	1.86484148
74	Preaxial hand polydactyly (HP:0001177)	1.86402769
75	Rectovaginal fistula (HP:0000143)	1.85900580
76	Rectal fistula (HP:0100590)	1.85900580
77	Methylmalonic aciduria (HP:0012120)	1.85164923
78	Microglossia (HP:0000171)	1.84895308
79	Tubulointerstitial nephritis (HP:0001970)	1.83918457
80	Sloping forehead (HP:0000340)	1.80848898
81	Abnormality of serum amino acid levels (HP:0003112)	1.80199754
82	True hermaphroditism (HP:0010459)	1.79715933
83	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.79050855
84	Abnormality of the clitoris (HP:0000056)	1.78544056
85	Abnormality of vitamin B metabolism (HP:0004340)	1.78466128
86	Medial flaring of the eyebrow (HP:0010747)	1.75683049
87	Neoplasm of the colon (HP:0100273)	1.75430927
88	Neoplasm of striated muscle (HP:0009728)	1.74281096
89	Abnormality of the metopic suture (HP:0005556)	1.74153966
90	Stenosis of the external auditory canal (HP:0000402)	1.74137626
91	Neoplasm of the adrenal gland (HP:0100631)	1.73080359
92	Septate vagina (HP:0001153)	1.73067639
93	Neoplasm of the small intestine (HP:0100833)	1.71958494
94	Hyperinsulinemic hypoglycemia (HP:0000825)	1.71736907
95	Pancreatic cysts (HP:0001737)	1.71657558
96	Optic nerve coloboma (HP:0000588)	1.71493566
97	Hypoglycemic seizures (HP:0002173)	1.71175300
98	Clitoromegaly (HP:0000057)	1.70652176
99	Hypomagnesemia (HP:0002917)	1.70604539
100	Abnormality of chromosome segregation (HP:0002916)	1.70101785

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	4.54860283
2	CASK	3.42824617
3	TRIM28	3.28168547
4	WNK3	2.98337456
5	TTK	2.84991132
6	CDK19	2.67536639
7	BRSK2	2.62534939
8	ZAK	2.58415931
9	ACVR1B	2.38010929
10	CDC7	2.35084024
11	TSSK6	2.33841454
12	PRKD3	2.32498345
13	SRPK1	2.27441754
14	MKNK2	2.25809576
15	PLK4	2.05677089
16	NEK1	2.05584311
17	EIF2AK3	1.91721181
18	MKNK1	1.90306184
19	WEE1	1.71934493
20	BCR	1.71345541
21	PLK3	1.58489619
22	DYRK3	1.58481282
23	PLK1	1.54003088
24	PASK	1.50633902
25	MET	1.42805808
26	PBK	1.39089115
27	TNIK	1.37940562
28	CAMK1G	1.36750182
29	FGR	1.34294507
30	MST4	1.34023058
31	BRSK1	1.31338486
32	STK38L	1.30351285
33	ATR	1.28340278
34	PDK2	1.24638374
35	NUAK1	1.21338081
36	YES1	1.13723547
37	ERBB3	1.10003189
38	CHEK2	1.06745507
39	BUB1	1.03161950
40	OXSR1	0.99788351
41	CCNB1	0.99747990
42	PLK2	0.96845260
43	MAP3K6	0.93153617
44	PTK2B	0.92326963
45	MAP3K4	0.85286716
46	TAF1	0.85123250
47	BMPR1B	0.83628797
48	CDK6	0.83064231
49	ATM	0.78897678
50	MAPK13	0.76648827
51	PINK1	0.74064449
52	BMX	0.73386997
53	CSNK1G1	0.65409953
54	NEK2	0.65254565
55	STK3	0.63854626
56	PRKD2	0.61955847
57	FGFR2	0.61814515
58	STK39	0.61112134
59	KSR1	0.59733787
60	EIF2AK1	0.58234710
61	CHEK1	0.57452226
62	SIK3	0.56940930
63	TGFBR1	0.54646703
64	CSNK1G2	0.54432718
65	MINK1	0.54008870
66	RPS6KA4	0.50521697
67	FGFR1	0.50449362
68	DYRK2	0.49805746
69	MATK	0.49528738
70	PRKCE	0.47452894
71	FRK	0.46526898
72	BCKDK	0.46428944
73	AURKB	0.45513786
74	PRKCI	0.44800383
75	VRK1	0.44720059
76	UHMK1	0.44661952
77	PRKCG	0.42112965
78	BRD4	0.42057088
79	BRAF	0.41633635
80	CDK1	0.41106907
81	CLK1	0.40911172
82	MAP3K9	0.40787149
83	RET	0.39708697
84	WNK4	0.37939116
85	GRK1	0.33900154
86	CDK11A	0.33889112
87	AURKA	0.33507822
88	STK24	0.32459957
89	CSNK1G3	0.32375298
90	PRKDC	0.31582279
91	CDK18	0.31368146
92	CAMKK2	0.30519371
93	TYRO3	0.30216290
94	PRKCH	0.30046809
95	NLK	0.29973521
96	MAP3K2	0.29709441
97	CSNK1E	0.29674518
98	CDK2	0.29550411
99	RPS6KB1	0.29500286
100	ALK	0.29032254

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Mismatch repair_Homo sapiens_hsa03430	3.60488703
2	Steroid biosynthesis_Homo sapiens_hsa00100	3.28731518
3	Non-homologous end-joining_Homo sapiens_hsa03450	3.16992007
4	DNA replication_Homo sapiens_hsa03030	3.12460463
5	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.82694344
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.69323403
7	RNA transport_Homo sapiens_hsa03013	2.68825596
8	Homologous recombination_Homo sapiens_hsa03440	2.48575291
9	Basal transcription factors_Homo sapiens_hsa03022	2.47472751
10	Fanconi anemia pathway_Homo sapiens_hsa03460	2.41794522
11	Cell cycle_Homo sapiens_hsa04110	2.40171116
12	Base excision repair_Homo sapiens_hsa03410	2.39531921
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.37908138
14	Protein export_Homo sapiens_hsa03060	2.32945778
15	Propanoate metabolism_Homo sapiens_hsa00640	2.20072443
16	mRNA surveillance pathway_Homo sapiens_hsa03015	2.16315371
17	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.06355761
18	Nucleotide excision repair_Homo sapiens_hsa03420	1.97723981
19	RNA degradation_Homo sapiens_hsa03018	1.97379130
20	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.94886854
21	Oocyte meiosis_Homo sapiens_hsa04114	1.78897240
22	Spliceosome_Homo sapiens_hsa03040	1.72540451
23	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.64636138
24	RNA polymerase_Homo sapiens_hsa03020	1.61771100
25	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.55105814
26	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.52345524
27	Fatty acid elongation_Homo sapiens_hsa00062	1.51917887
28	Selenocompound metabolism_Homo sapiens_hsa00450	1.51661517
29	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.49077732
30	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.41671598
31	Proteasome_Homo sapiens_hsa03050	1.35024937
32	Butanoate metabolism_Homo sapiens_hsa00650	1.31532453
33	Regulation of autophagy_Homo sapiens_hsa04140	1.20538725
34	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.14460030
35	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.13837010
36	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.12225686
37	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.08226469
38	Pyruvate metabolism_Homo sapiens_hsa00620	1.05270836
39	Sulfur metabolism_Homo sapiens_hsa00920	1.02032079
40	Pyrimidine metabolism_Homo sapiens_hsa00240	0.99359315
41	p53 signaling pathway_Homo sapiens_hsa04115	0.93975446
42	Folate biosynthesis_Homo sapiens_hsa00790	0.93329481
43	One carbon pool by folate_Homo sapiens_hsa00670	0.91847817
44	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.90418342
45	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.87273857
46	Fatty acid metabolism_Homo sapiens_hsa01212	0.84684501
47	Purine metabolism_Homo sapiens_hsa00230	0.83212988
48	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.71671490
49	Caffeine metabolism_Homo sapiens_hsa00232	0.71072413
50	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.69900330
51	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.69244627
52	Glutathione metabolism_Homo sapiens_hsa00480	0.66478447
53	Phototransduction_Homo sapiens_hsa04744	0.66456342
54	Alcoholism_Homo sapiens_hsa05034	0.62547784
55	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.61391011
56	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.59956711
57	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.59129594
58	Tight junction_Homo sapiens_hsa04530	0.59097412
59	Hippo signaling pathway_Homo sapiens_hsa04390	0.58104491
60	Peroxisome_Homo sapiens_hsa04146	0.53932801
61	Carbon metabolism_Homo sapiens_hsa01200	0.52321427
62	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.52116718
63	beta-Alanine metabolism_Homo sapiens_hsa00410	0.51490651
64	Huntingtons disease_Homo sapiens_hsa05016	0.51489597
65	Fatty acid degradation_Homo sapiens_hsa00071	0.48121424
66	Dopaminergic synapse_Homo sapiens_hsa04728	0.47367259
67	Long-term depression_Homo sapiens_hsa04730	0.47125946
68	Parkinsons disease_Homo sapiens_hsa05012	0.45745593
69	Lysine degradation_Homo sapiens_hsa00310	0.45707349
70	Metabolic pathways_Homo sapiens_hsa01100	0.43359922
71	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.42991968
72	Nicotine addiction_Homo sapiens_hsa05033	0.42545600
73	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.37920928
74	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.37301469
75	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.37095695
76	Sulfur relay system_Homo sapiens_hsa04122	0.36106454
77	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.33784472
78	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.32340329
79	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.30819252
80	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.30094851
81	Retinol metabolism_Homo sapiens_hsa00830	0.29561521
82	Oxidative phosphorylation_Homo sapiens_hsa00190	0.28441872
83	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.27577386
84	AMPK signaling pathway_Homo sapiens_hsa04152	0.25357090
85	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.24029125
86	Wnt signaling pathway_Homo sapiens_hsa04310	0.23696650
87	Ether lipid metabolism_Homo sapiens_hsa00565	0.23581863
88	Tryptophan metabolism_Homo sapiens_hsa00380	0.22815459
89	Gap junction_Homo sapiens_hsa04540	0.21157143
90	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.19317741
91	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.19010291
92	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.18347600
93	GABAergic synapse_Homo sapiens_hsa04727	0.18285174
94	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.18012334
95	Circadian rhythm_Homo sapiens_hsa04710	0.15229088
96	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.15210841
97	Linoleic acid metabolism_Homo sapiens_hsa00591	0.14948412
98	Taste transduction_Homo sapiens_hsa04742	0.14871020
99	Adherens junction_Homo sapiens_hsa04520	0.14839783
100	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.13884005

ZNF92P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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