ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	platelet dense granule organization (GO:0060155)	5.15577928
2	response to pheromone (GO:0019236)	4.70561682
3	DNA integration (GO:0015074)	4.43856844
4	DNA double-strand break processing (GO:0000729)	4.09902527
5	behavioral response to nicotine (GO:0035095)	4.04311784
6	C4-dicarboxylate transport (GO:0015740)	3.86098768
7	piRNA metabolic process (GO:0034587)	3.83049196
8	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.72241907
9	regulation of mitotic spindle checkpoint (GO:1903504)	3.72241907
10	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.69031766
11	tryptophan catabolic process (GO:0006569)	3.60847232
12	indole-containing compound catabolic process (GO:0042436)	3.60847232
13	indolalkylamine catabolic process (GO:0046218)	3.60847232
14	neural tube formation (GO:0001841)	3.55392044
15	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.50253676
16	indolalkylamine metabolic process (GO:0006586)	3.43875394
17	fucose catabolic process (GO:0019317)	3.39738773
18	L-fucose metabolic process (GO:0042354)	3.39738773
19	L-fucose catabolic process (GO:0042355)	3.39738773
20	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.37962692
21	kynurenine metabolic process (GO:0070189)	3.21170057
22	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.17271489
23	protein K6-linked ubiquitination (GO:0085020)	3.16212131
24	gamma-aminobutyric acid transport (GO:0015812)	3.14554610
25	replication fork processing (GO:0031297)	3.12893712
26	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.10736333
27	regulation of hexokinase activity (GO:1903299)	3.09934989
28	regulation of glucokinase activity (GO:0033131)	3.09934989
29	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.08594564
30	tryptophan metabolic process (GO:0006568)	3.03134763
31	water-soluble vitamin biosynthetic process (GO:0042364)	3.02482598
32	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.99385702
33	cilium morphogenesis (GO:0060271)	2.99127503
34	sulfation (GO:0051923)	2.98180130
35	negative regulation of mast cell activation (GO:0033004)	2.97563302
36	presynaptic membrane assembly (GO:0097105)	2.95555231
37	respiratory chain complex IV assembly (GO:0008535)	2.95038387
38	DNA deamination (GO:0045006)	2.91357493
39	cilium or flagellum-dependent cell motility (GO:0001539)	2.90286240
40	anterograde synaptic vesicle transport (GO:0048490)	2.87707331
41	somite development (GO:0061053)	2.87348226
42	synapsis (GO:0007129)	2.84924932
43	double-strand break repair via homologous recombination (GO:0000724)	2.83926001
44	NADH dehydrogenase complex assembly (GO:0010257)	2.82741073
45	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.82741073
46	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.82741073
47	recombinational repair (GO:0000725)	2.82597971
48	DNA methylation involved in gamete generation (GO:0043046)	2.82384400
49	head development (GO:0060322)	2.81478104
50	auditory behavior (GO:0031223)	2.80217507
51	regulation of cilium movement (GO:0003352)	2.79124869
52	regulation of DNA endoreduplication (GO:0032875)	2.78165302
53	fucosylation (GO:0036065)	2.78103298
54	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.74737724
55	synaptic transmission, cholinergic (GO:0007271)	2.73194910
56	negative regulation of telomere maintenance (GO:0032205)	2.71292574
57	preassembly of GPI anchor in ER membrane (GO:0016254)	2.70955689
58	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.70288457
59	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	2.69041824
60	mechanosensory behavior (GO:0007638)	2.66973690
61	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.66413488
62	indole-containing compound metabolic process (GO:0042430)	2.65657919
63	cAMP catabolic process (GO:0006198)	2.65066685
64	amine catabolic process (GO:0009310)	2.65020681
65	cellular biogenic amine catabolic process (GO:0042402)	2.65020681
66	photoreceptor cell maintenance (GO:0045494)	2.64716318
67	resolution of meiotic recombination intermediates (GO:0000712)	2.64716255
68	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.63030109
69	detection of light stimulus involved in visual perception (GO:0050908)	2.62574699
70	detection of light stimulus involved in sensory perception (GO:0050962)	2.62574699
71	polyol catabolic process (GO:0046174)	2.62039261
72	behavioral response to ethanol (GO:0048149)	2.61398237
73	protein polyglutamylation (GO:0018095)	2.61202225
74	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.59672802
75	regulation of translation, ncRNA-mediated (GO:0045974)	2.59672802
76	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.59672802
77	male meiosis (GO:0007140)	2.56657320
78	cilium organization (GO:0044782)	2.55515334
79	cellular ketone body metabolic process (GO:0046950)	2.54476438
80	righting reflex (GO:0060013)	2.54409773
81	cilium assembly (GO:0042384)	2.53893771
82	protein complex biogenesis (GO:0070271)	2.53530839
83	intra-S DNA damage checkpoint (GO:0031573)	2.53406256
84	mesenchymal cell differentiation involved in renal system development (GO:2001012)	2.53342591
85	mesenchymal cell differentiation involved in kidney development (GO:0072161)	2.53342591
86	reflex (GO:0060004)	2.52425373
87	pyrimidine nucleobase catabolic process (GO:0006208)	2.52108884
88	inner ear receptor stereocilium organization (GO:0060122)	2.51967464
89	axoneme assembly (GO:0035082)	2.50226894
90	postsynaptic membrane organization (GO:0001941)	2.48792136
91	fatty acid elongation (GO:0030497)	2.48772365
92	DNA strand renaturation (GO:0000733)	2.48763751
93	rRNA catabolic process (GO:0016075)	2.48541018
94	presynaptic membrane organization (GO:0097090)	2.46949247
95	positive regulation of cAMP-mediated signaling (GO:0043950)	2.46140218
96	regulation of timing of cell differentiation (GO:0048505)	2.45883759
97	DNA demethylation (GO:0080111)	2.45091156
98	protein deneddylation (GO:0000338)	2.45051258
99	proline transport (GO:0015824)	2.43664673
100	ketone body metabolic process (GO:1902224)	2.43551541

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.61617185
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.45557511
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.40585309
4	VDR_22108803_ChIP-Seq_LS180_Human	3.37487407
5	IGF1R_20145208_ChIP-Seq_DFB_Human	3.06267616
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.90807330
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.81462828
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.76595940
9	FUS_26573619_Chip-Seq_HEK293_Human	2.52514883
10	EWS_26573619_Chip-Seq_HEK293_Human	2.49240830
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.38871817
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.35578602
13	P300_19829295_ChIP-Seq_ESCs_Human	2.34666867
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.25354767
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.21890914
16	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.13056201
17	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.00791731
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.96995200
19	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.87516327
20	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.84096907
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.78896327
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.76183735
23	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.75181017
24	EZH2_22144423_ChIP-Seq_EOC_Human	1.74098244
25	BCAT_22108803_ChIP-Seq_LS180_Human	1.73876075
26	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.73245784
27	SMAD4_21799915_ChIP-Seq_A2780_Human	1.70766516
28	STAT3_23295773_ChIP-Seq_U87_Human	1.67066023
29	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.66967337
30	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.62648278
31	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.61009062
32	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.57664794
33	CBP_20019798_ChIP-Seq_JUKART_Human	1.56084518
34	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.56084518
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.55985593
36	AR_25329375_ChIP-Seq_VCAP_Human	1.55696152
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.54902829
38	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.52974967
39	TCF4_23295773_ChIP-Seq_U87_Human	1.52261159
40	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.52254484
41	IRF1_19129219_ChIP-ChIP_H3396_Human	1.49344606
42	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.46937995
43	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.46818821
44	TCF4_22108803_ChIP-Seq_LS180_Human	1.46688107
45	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.45989326
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.45148429
47	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.43699284
48	NANOG_19829295_ChIP-Seq_ESCs_Human	1.43610738
49	SOX2_19829295_ChIP-Seq_ESCs_Human	1.43610738
50	ELK1_19687146_ChIP-ChIP_HELA_Human	1.43085274
51	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.42009914
52	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.41293181
53	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.40916139
54	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.38988338
55	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.38546294
56	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.38546294
57	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.35745694
58	RUNX2_22187159_ChIP-Seq_PCA_Human	1.32964536
59	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.32671084
60	AR_21572438_ChIP-Seq_LNCaP_Human	1.29452320
61	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.28085461
62	TP53_22573176_ChIP-Seq_HFKS_Human	1.27055296
63	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.23555159
64	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.22360889
65	MYC_18940864_ChIP-ChIP_HL60_Human	1.21452040
66	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.21036566
67	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.20937086
68	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.20069588
69	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.19510643
70	TP53_16413492_ChIP-PET_HCT116_Human	1.19317827
71	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.18626961
72	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.18127766
73	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.16994918
74	P53_22387025_ChIP-Seq_ESCs_Mouse	1.16052143
75	RNF2_27304074_Chip-Seq_NSC_Mouse	1.15025802
76	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.15018660
77	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.14626777
78	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.13805524
79	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.10364472
80	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.10143434
81	REST_21632747_ChIP-Seq_MESCs_Mouse	1.06130427
82	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.06059647
83	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.04941752
84	CDX2_22108803_ChIP-Seq_LS180_Human	1.04871654
85	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.03479629
86	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.03402791
87	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.01319303
88	JUN_21703547_ChIP-Seq_K562_Human	1.01154511
89	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.00995747
90	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.98981781
91	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.98981781
92	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.98655243
93	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98632251
94	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.98155271
95	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.97903202
96	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.96629156
97	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.96609694
98	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.96550765
99	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.95379938
100	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.95165907

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.09981906
2	MP0000569_abnormal_digit_pigmentation	3.01774978
3	MP0008877_abnormal_DNA_methylation	2.94995451
4	MP0002102_abnormal_ear_morphology	2.82835797
5	MP0001529_abnormal_vocalization	2.68320641
6	MP0001968_abnormal_touch/_nociception	2.56087965
7	MP0002736_abnormal_nociception_after	2.54618858
8	MP0005551_abnormal_eye_electrophysiolog	2.52308754
9	MP0003195_calcinosis	2.21119166
10	MP0009697_abnormal_copulation	2.06968830
11	MP0005167_abnormal_blood-brain_barrier	2.05128795
12	MP0003136_yellow_coat_color	2.01231145
13	MP0001485_abnormal_pinna_reflex	2.01031400
14	MP0000383_abnormal_hair_follicle	2.00334264
15	MP0005253_abnormal_eye_physiology	1.94229224
16	MP0000427_abnormal_hair_cycle	1.89157861
17	MP0002638_abnormal_pupillary_reflex	1.86329172
18	MP0006276_abnormal_autonomic_nervous	1.83675778
19	MP0005174_abnormal_tail_pigmentation	1.83011271
20	MP0004133_heterotaxia	1.79075021
21	MP0009046_muscle_twitch	1.79037613
22	MP0006072_abnormal_retinal_apoptosis	1.76930768
23	MP0000372_irregular_coat_pigmentation	1.76281631
24	MP0008872_abnormal_physiological_respon	1.72778562
25	MP0001486_abnormal_startle_reflex	1.72421108
26	MP0002254_reproductive_system_inflammat	1.72247108
27	MP0008875_abnormal_xenobiotic_pharmacok	1.67213173
28	MP0000015_abnormal_ear_pigmentation	1.66284587
29	MP0006292_abnormal_olfactory_placode	1.62568708
30	MP0003183_abnormal_peptide_metabolism	1.56217393
31	MP0004142_abnormal_muscle_tone	1.55156583
32	MP0002876_abnormal_thyroid_physiology	1.53714690
33	MP0008058_abnormal_DNA_repair	1.53198966
34	MP0002272_abnormal_nervous_system	1.52671794
35	MP0001293_anophthalmia	1.48605398
36	MP0009745_abnormal_behavioral_response	1.46999852
37	MP0002938_white_spotting	1.37762327
38	MP0002095_abnormal_skin_pigmentation	1.37154375
39	MP0000631_abnormal_neuroendocrine_gland	1.36571048
40	MP0000049_abnormal_middle_ear	1.35942837
41	MP0001188_hyperpigmentation	1.35280228
42	MP0002163_abnormal_gland_morphology	1.34532722
43	MP0005645_abnormal_hypothalamus_physiol	1.33471709
44	MP0002160_abnormal_reproductive_system	1.29837750
45	MP0003646_muscle_fatigue	1.28951322
46	MP0004215_abnormal_myocardial_fiber	1.27148393
47	MP0004924_abnormal_behavior	1.26097966
48	MP0005386_behavior/neurological_phenoty	1.26097966
49	MP0000566_synostosis	1.26084072
50	MP0002234_abnormal_pharynx_morphology	1.23458288
51	MP0003567_abnormal_fetal_cardiomyocyte	1.21522565
52	MP0002837_dystrophic_cardiac_calcinosis	1.18161258
53	MP0002653_abnormal_ependyma_morphology	1.17902575
54	MP0008789_abnormal_olfactory_epithelium	1.12333889
55	MP0009764_decreased_sensitivity_to	1.12202818
56	MP0000778_abnormal_nervous_system	1.08914684
57	MP0005389_reproductive_system_phenotype	1.08754363
58	MP0002733_abnormal_thermal_nociception	1.08412417
59	MP0003950_abnormal_plasma_membrane	1.08279380
60	MP0005195_abnormal_posterior_eye	1.08156057
61	MP0005391_vision/eye_phenotype	1.08102172
62	MP0010678_abnormal_skin_adnexa	1.07522412
63	MP0001501_abnormal_sleep_pattern	1.07027095
64	MP0002557_abnormal_social/conspecific_i	1.05604178
65	MP0006035_abnormal_mitochondrial_morpho	1.05236768
66	MP0003937_abnormal_limbs/digits/tail_de	1.04244438
67	MP0002572_abnormal_emotion/affect_behav	1.02056386
68	MP0004145_abnormal_muscle_electrophysio	1.00551467
69	MP0009384_cardiac_valve_regurgitation	0.99772268
70	MP0005646_abnormal_pituitary_gland	0.98756720
71	MP0005379_endocrine/exocrine_gland_phen	0.97041215
72	MP0003635_abnormal_synaptic_transmissio	0.96412169
73	MP0001970_abnormal_pain_threshold	0.95918475
74	MP0004885_abnormal_endolymph	0.92272488
75	MP0003119_abnormal_digestive_system	0.91860973
76	MP0002210_abnormal_sex_determination	0.91584125
77	MP0005410_abnormal_fertilization	0.91137112
78	MP0003698_abnormal_male_reproductive	0.90581210
79	MP0002233_abnormal_nose_morphology	0.90311020
80	MP0002067_abnormal_sensory_capabilities	0.89463586
81	MP0002752_abnormal_somatic_nervous	0.88235967
82	MP0003806_abnormal_nucleotide_metabolis	0.87795079
83	MP0001929_abnormal_gametogenesis	0.87247651
84	MP0001986_abnormal_taste_sensitivity	0.86655350
85	MP0000613_abnormal_salivary_gland	0.84246878
86	MP0003283_abnormal_digestive_organ	0.84166357
87	MP0004085_abnormal_heartbeat	0.83703769
88	MP0002064_seizures	0.83338732
89	MP0000647_abnormal_sebaceous_gland	0.82922714
90	MP0001346_abnormal_lacrimal_gland	0.81650850
91	MP0003718_maternal_effect	0.81360938
92	MP0000653_abnormal_sex_gland	0.78819808
93	MP0003137_abnormal_impulse_conducting	0.74461881
94	MP0003890_abnormal_embryonic-extraembry	0.74308662
95	MP0010094_abnormal_chromosome_stability	0.74064739
96	MP0004043_abnormal_pH_regulation	0.73495970
97	MP0001145_abnormal_male_reproductive	0.72370399
98	MP0001764_abnormal_homeostasis	0.71779861
99	MP0001963_abnormal_hearing_physiology	0.71151430
100	MP0002063_abnormal_learning/memory/cond	0.71035427

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.35433862
2	True hermaphroditism (HP:0010459)	4.30503891
3	Abnormality of midbrain morphology (HP:0002418)	4.21002766
4	Molar tooth sign on MRI (HP:0002419)	4.21002766
5	Pancreatic fibrosis (HP:0100732)	4.07986876
6	Nephronophthisis (HP:0000090)	3.64507321
7	Medial flaring of the eyebrow (HP:0010747)	3.38152866
8	Abnormality of the renal medulla (HP:0100957)	3.09942660
9	Fibular aplasia (HP:0002990)	3.09685964
10	Chronic hepatic failure (HP:0100626)	3.09646266
11	Gait imbalance (HP:0002141)	3.08261700
12	Colon cancer (HP:0003003)	3.04627483
13	Bile duct proliferation (HP:0001408)	2.98103383
14	Abnormal biliary tract physiology (HP:0012439)	2.98103383
15	Congenital primary aphakia (HP:0007707)	2.94892986
16	Cystic liver disease (HP:0006706)	2.80367653
17	Sclerocornea (HP:0000647)	2.77283379
18	Nephrogenic diabetes insipidus (HP:0009806)	2.75971751
19	Congenital stationary night blindness (HP:0007642)	2.74080163
20	Attenuation of retinal blood vessels (HP:0007843)	2.72934197
21	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.67968393
22	Abnormality of the renal cortex (HP:0011035)	2.65582660
23	Partial agenesis of the corpus callosum (HP:0001338)	2.41746180
24	Abnormality of macular pigmentation (HP:0008002)	2.41022497
25	Increased corneal curvature (HP:0100692)	2.39079375
26	Keratoconus (HP:0000563)	2.39079375
27	Preaxial hand polydactyly (HP:0001177)	2.38967390
28	Renal cortical cysts (HP:0000803)	2.37567628
29	Genital tract atresia (HP:0001827)	2.36242576
30	Vaginal atresia (HP:0000148)	2.35138406
31	Abolished electroretinogram (ERG) (HP:0000550)	2.32214603
32	Occipital encephalocele (HP:0002085)	2.27555723
33	Type 2 muscle fiber atrophy (HP:0003554)	2.25904014
34	Progressive inability to walk (HP:0002505)	2.24794972
35	Type II lissencephaly (HP:0007260)	2.24138134
36	Methylmalonic acidemia (HP:0002912)	2.23039813
37	Optic nerve hypoplasia (HP:0000609)	2.22119347
38	Narrow forehead (HP:0000341)	2.21401250
39	Abnormality of the labia minora (HP:0012880)	2.19953270
40	Asplenia (HP:0001746)	2.19446437
41	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.17346708
42	Poor coordination (HP:0002370)	2.17143845
43	Broad ribs (HP:0000885)	2.16749122
44	Intestinal atresia (HP:0011100)	2.16659602
45	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.14847119
46	Anencephaly (HP:0002323)	2.14224080
47	Abnormal rod and cone electroretinograms (HP:0008323)	2.14136744
48	Congenital hepatic fibrosis (HP:0002612)	2.13784691
49	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.12796375
50	Postaxial foot polydactyly (HP:0001830)	2.12767140
51	Congenital sensorineural hearing impairment (HP:0008527)	2.12333610
52	Tubular atrophy (HP:0000092)	2.10838602
53	Pendular nystagmus (HP:0012043)	2.09296125
54	Male pseudohermaphroditism (HP:0000037)	2.07318430
55	Furrowed tongue (HP:0000221)	2.06699219
56	Supernumerary spleens (HP:0009799)	2.06364390
57	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.05433382
58	Postaxial hand polydactyly (HP:0001162)	2.03160128
59	Bony spicule pigmentary retinopathy (HP:0007737)	2.02654054
60	Absent/shortened dynein arms (HP:0200106)	2.02606234
61	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.02606234
62	Hypoplastic iliac wings (HP:0002866)	2.02359294
63	Hyperventilation (HP:0002883)	2.01807643
64	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.01179610
65	Abnormality of alanine metabolism (HP:0010916)	2.01179610
66	Hyperalaninemia (HP:0003348)	2.01179610
67	Wide intermamillary distance (HP:0006610)	1.97624766
68	Gaze-evoked nystagmus (HP:0000640)	1.96898789
69	Congenital, generalized hypertrichosis (HP:0004540)	1.95475706
70	Large for gestational age (HP:0001520)	1.94266256
71	Lissencephaly (HP:0001339)	1.91553663
72	Abnormal drinking behavior (HP:0030082)	1.88815777
73	Polydipsia (HP:0001959)	1.88815777
74	Methylmalonic aciduria (HP:0012120)	1.83288677
75	Oligohydramnios (HP:0001562)	1.77740946
76	Chorioretinal atrophy (HP:0000533)	1.77642434
77	Polyuria (HP:0000103)	1.77618778
78	Astigmatism (HP:0000483)	1.77379099
79	Inability to walk (HP:0002540)	1.76851889
80	Abnormality of the ileum (HP:0001549)	1.76445767
81	Fibular hypoplasia (HP:0003038)	1.75398467
82	Gastrointestinal atresia (HP:0002589)	1.73483342
83	Broad foot (HP:0001769)	1.73225896
84	Dyskinesia (HP:0100660)	1.72457524
85	Sloping forehead (HP:0000340)	1.72053821
86	Cupped ear (HP:0000378)	1.71503813
87	Choroideremia (HP:0001139)	1.70831715
88	Focal motor seizures (HP:0011153)	1.70511339
89	Highly arched eyebrow (HP:0002553)	1.69670316
90	Hepatocellular necrosis (HP:0001404)	1.69637509
91	Broad-based gait (HP:0002136)	1.69407993
92	Muscle fiber atrophy (HP:0100295)	1.68857316
93	Tachypnea (HP:0002789)	1.68436128
94	Multicystic kidney dysplasia (HP:0000003)	1.68064573
95	Aganglionic megacolon (HP:0002251)	1.67750322
96	Hypoplasia of the fovea (HP:0007750)	1.67435353
97	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.67435353
98	Limb dystonia (HP:0002451)	1.67364171
99	Hemiparesis (HP:0001269)	1.66559983
100	Dandy-Walker malformation (HP:0001305)	1.64067786

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.57992670
2	ADRBK2	3.17238419
3	VRK2	2.98315644
4	NUAK1	2.76587074
5	NEK1	2.65981816
6	EPHA4	2.39379472
7	GRK1	2.29369044
8	CASK	2.15311536
9	WNK3	2.12556418
10	MAP4K2	2.12499244
11	BMPR1B	2.04300362
12	INSRR	1.99364565
13	STK38L	1.94398895
14	EIF2AK1	1.92983564
15	TNIK	1.90773745
16	MAPK13	1.82457091
17	TIE1	1.81344235
18	EIF2AK3	1.66375676
19	TAF1	1.61802729
20	WEE1	1.59290514
21	WNK4	1.55950695
22	ZAK	1.55859980
23	PIM2	1.51396242
24	STK39	1.50446724
25	PLK2	1.44418857
26	VRK1	1.39171544
27	PINK1	1.37049093
28	OXSR1	1.33536244
29	PNCK	1.24672887
30	DYRK2	1.24299217
31	DAPK2	1.22452933
32	ARAF	1.20451374
33	MUSK	1.17738952
34	PTK2B	1.13669949
35	CDC7	1.12751070
36	CSNK1G1	1.11236852
37	TRIM28	1.10017091
38	GRK5	1.09598021
39	MAP3K4	1.09312783
40	PRKCE	1.09067091
41	CSNK1G2	1.08063643
42	CSNK1G3	1.05454200
43	CSNK1A1L	1.03706054
44	ACVR1B	1.02641499
45	STK3	0.96244187
46	BRSK2	0.96091211
47	LATS1	0.95498752
48	TEC	0.92151366
49	TAOK3	0.91004659
50	TGFBR1	0.90714018
51	PLK3	0.90308510
52	ADRBK1	0.89224967
53	BCR	0.88668870
54	PDK2	0.87304180
55	MKNK1	0.85462048
56	MAPKAPK5	0.83771497
57	GRK7	0.83740789
58	PRKCG	0.80569653
59	MST4	0.80187861
60	ERBB3	0.77649563
61	PKN1	0.74493912
62	DYRK3	0.72561314
63	SRPK1	0.70446069
64	MKNK2	0.66759733
65	NME1	0.66421065
66	MARK1	0.65250742
67	FGFR2	0.64726151
68	PLK4	0.62615771
69	CCNB1	0.61863731
70	CDK3	0.58382997
71	EIF2AK2	0.58362194
72	PRKCI	0.57227133
73	PAK3	0.56110763
74	DYRK1A	0.55827786
75	CHEK2	0.54971643
76	CDK9	0.54827798
77	MAP2K7	0.53625313
78	EPHA3	0.50788107
79	BRAF	0.50770518
80	RPS6KA4	0.50321602
81	WNK1	0.49893980
82	PRKG2	0.48327445
83	MAP2K6	0.48271907
84	RPS6KA5	0.47653215
85	CAMK2A	0.47458890
86	TLK1	0.46268272
87	CDK8	0.46246270
88	AKT3	0.41901816
89	EPHB2	0.41880747
90	CSNK1D	0.41816610
91	CSNK1A1	0.41196659
92	CAMK4	0.40020831
93	PRKG1	0.38079411
94	PRKACA	0.36199416
95	MINK1	0.34882392
96	FGFR1	0.34607655
97	ITK	0.32192415
98	TXK	0.32009542
99	ATM	0.30114121
100	NEK2	0.30031272

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.01190705
2	Selenocompound metabolism_Homo sapiens_hsa00450	2.83926467
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.50715562
4	Phototransduction_Homo sapiens_hsa04744	2.48043481
5	Homologous recombination_Homo sapiens_hsa03440	2.37401701
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.28470549
7	Butanoate metabolism_Homo sapiens_hsa00650	2.27469136
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.24552845
9	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.16400887
10	Caffeine metabolism_Homo sapiens_hsa00232	2.11594989
11	Protein export_Homo sapiens_hsa03060	2.00643497
12	Basal transcription factors_Homo sapiens_hsa03022	1.96272296
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.94596597
14	Propanoate metabolism_Homo sapiens_hsa00640	1.80297110
15	Nicotine addiction_Homo sapiens_hsa05033	1.79740518
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.77500737
17	Tryptophan metabolism_Homo sapiens_hsa00380	1.74698680
18	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.72390425
19	RNA polymerase_Homo sapiens_hsa03020	1.72120085
20	Olfactory transduction_Homo sapiens_hsa04740	1.71901665
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.71756309
22	One carbon pool by folate_Homo sapiens_hsa00670	1.70134501
23	Ether lipid metabolism_Homo sapiens_hsa00565	1.62238305
24	Oxidative phosphorylation_Homo sapiens_hsa00190	1.60138379
25	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.55494176
26	RNA degradation_Homo sapiens_hsa03018	1.49235637
27	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.48765629
28	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.47476092
29	Parkinsons disease_Homo sapiens_hsa05012	1.46778232
30	Taste transduction_Homo sapiens_hsa04742	1.43099534
31	ABC transporters_Homo sapiens_hsa02010	1.39028462
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.38475541
33	Huntingtons disease_Homo sapiens_hsa05016	1.36326527
34	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.35046758
35	Sulfur metabolism_Homo sapiens_hsa00920	1.34936366
36	Non-homologous end-joining_Homo sapiens_hsa03450	1.31988112
37	Morphine addiction_Homo sapiens_hsa05032	1.31473812
38	Glutamatergic synapse_Homo sapiens_hsa04724	1.29270672
39	Regulation of autophagy_Homo sapiens_hsa04140	1.21196208
40	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.15540859
41	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.14098576
42	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.11783185
43	Steroid biosynthesis_Homo sapiens_hsa00100	1.08669909
44	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.03058190
45	Serotonergic synapse_Homo sapiens_hsa04726	1.01758559
46	Circadian entrainment_Homo sapiens_hsa04713	1.00221943
47	Fatty acid degradation_Homo sapiens_hsa00071	0.96732230
48	Peroxisome_Homo sapiens_hsa04146	0.94886300
49	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.94653709
50	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.93650229
51	Alzheimers disease_Homo sapiens_hsa05010	0.92232457
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.91748777
53	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.90841926
54	Fatty acid metabolism_Homo sapiens_hsa01212	0.90185083
55	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.89239974
56	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.88433774
57	Circadian rhythm_Homo sapiens_hsa04710	0.85225870
58	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.84131592
59	GABAergic synapse_Homo sapiens_hsa04727	0.83360688
60	Salivary secretion_Homo sapiens_hsa04970	0.82864934
61	Glycerolipid metabolism_Homo sapiens_hsa00561	0.81379017
62	Mismatch repair_Homo sapiens_hsa03430	0.79332715
63	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.79088256
64	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.76852808
65	Purine metabolism_Homo sapiens_hsa00230	0.74599097
66	Insulin secretion_Homo sapiens_hsa04911	0.70687676
67	beta-Alanine metabolism_Homo sapiens_hsa00410	0.70251725
68	Proteasome_Homo sapiens_hsa03050	0.68115782
69	Pyrimidine metabolism_Homo sapiens_hsa00240	0.65719968
70	Metabolic pathways_Homo sapiens_hsa01100	0.64663265
71	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.62314866
72	p53 signaling pathway_Homo sapiens_hsa04115	0.61748742
73	Nucleotide excision repair_Homo sapiens_hsa03420	0.61668994
74	Retinol metabolism_Homo sapiens_hsa00830	0.60179023
75	RNA transport_Homo sapiens_hsa03013	0.58260531
76	Sulfur relay system_Homo sapiens_hsa04122	0.57903193
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.54710350
78	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.53090762
79	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.52533610
80	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.52150140
81	Amphetamine addiction_Homo sapiens_hsa05031	0.52119738
82	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.51722139
83	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.51612974
84	Calcium signaling pathway_Homo sapiens_hsa04020	0.50981124
85	Long-term depression_Homo sapiens_hsa04730	0.50642692
86	Dopaminergic synapse_Homo sapiens_hsa04728	0.48736725
87	Sphingolipid metabolism_Homo sapiens_hsa00600	0.48264537
88	Cardiac muscle contraction_Homo sapiens_hsa04260	0.48205854
89	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.47817537
90	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.47377259
91	Basal cell carcinoma_Homo sapiens_hsa05217	0.45083543
92	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.44838517
93	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.44619716
94	Histidine metabolism_Homo sapiens_hsa00340	0.44331753
95	Hippo signaling pathway_Homo sapiens_hsa04390	0.43578709
96	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.42670545
97	Fatty acid elongation_Homo sapiens_hsa00062	0.42122121
98	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.42059102
99	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.40138942
100	Glutathione metabolism_Homo sapiens_hsa00480	0.39217734

ZNF962P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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