ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sphingosine metabolic process (GO:0006670)	5.50100718
2	behavioral response to nicotine (GO:0035095)	5.23816707
3	diol metabolic process (GO:0034311)	5.06301284
4	DNA methylation involved in gamete generation (GO:0043046)	4.89997011
5	sphingoid metabolic process (GO:0046519)	4.86857054
6	piRNA metabolic process (GO:0034587)	4.69484973
7	DNA deamination (GO:0045006)	4.51933746
8	fucose catabolic process (GO:0019317)	4.50747900
9	L-fucose metabolic process (GO:0042354)	4.50747900
10	L-fucose catabolic process (GO:0042355)	4.50747900
11	regulation of meiosis I (GO:0060631)	4.39962374
12	indolalkylamine catabolic process (GO:0046218)	3.97346753
13	tryptophan catabolic process (GO:0006569)	3.97346753
14	indole-containing compound catabolic process (GO:0042436)	3.97346753
15	response to pheromone (GO:0019236)	3.88665160
16	indolalkylamine metabolic process (GO:0006586)	3.75866877
17	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.58806932
18	kynurenine metabolic process (GO:0070189)	3.56819367
19	protein K11-linked deubiquitination (GO:0035871)	3.49901837
20	platelet dense granule organization (GO:0060155)	3.49234819
21	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.48770705
22	negative regulation of telomere maintenance (GO:0032205)	3.44113578
23	tryptophan metabolic process (GO:0006568)	3.40125679
24	DNA double-strand break processing (GO:0000729)	3.31816507
25	sulfation (GO:0051923)	3.29312045
26	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	3.28310858
27	sulfate transmembrane transport (GO:1902358)	3.27889762
28	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.26481399
29	NADH dehydrogenase complex assembly (GO:0010257)	3.26481399
30	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.26481399
31	heme transport (GO:0015886)	3.24265080
32	adaptation of signaling pathway (GO:0023058)	3.24053909
33	regulation of rhodopsin mediated signaling pathway (GO:0022400)	3.22544811
34	positive regulation of meiosis (GO:0045836)	3.17767552
35	centriole replication (GO:0007099)	3.12577318
36	rhodopsin mediated signaling pathway (GO:0016056)	3.05826106
37	protein complex biogenesis (GO:0070271)	3.03537550
38	water-soluble vitamin biosynthetic process (GO:0042364)	3.02275192
39	regulation of protein glycosylation (GO:0060049)	3.02112220
40	vitamin transmembrane transport (GO:0035461)	3.00437247
41	aromatic amino acid family catabolic process (GO:0009074)	2.99389894
42	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.98781787
43	negative regulation of mast cell activation (GO:0033004)	2.97708288
44	meiotic chromosome segregation (GO:0045132)	2.97242060
45	positive regulation of meiotic cell cycle (GO:0051446)	2.96420536
46	cellular ketone body metabolic process (GO:0046950)	2.95394174
47	amine catabolic process (GO:0009310)	2.92852952
48	cellular biogenic amine catabolic process (GO:0042402)	2.92852952
49	protein-chromophore linkage (GO:0018298)	2.92699386
50	sulfate transport (GO:0008272)	2.91330626
51	glycerophospholipid catabolic process (GO:0046475)	2.90407932
52	detection of light stimulus involved in visual perception (GO:0050908)	2.88338740
53	detection of light stimulus involved in sensory perception (GO:0050962)	2.88338740
54	serotonin receptor signaling pathway (GO:0007210)	2.87239644
55	lipopolysaccharide biosynthetic process (GO:0009103)	2.86524122
56	reciprocal meiotic recombination (GO:0007131)	2.83139867
57	reciprocal DNA recombination (GO:0035825)	2.83139867
58	mitochondrial respiratory chain complex assembly (GO:0033108)	2.79630355
59	axoneme assembly (GO:0035082)	2.79171157
60	indole-containing compound metabolic process (GO:0042430)	2.78884782
61	protein K6-linked ubiquitination (GO:0085020)	2.78438181
62	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.76040566
63	reflex (GO:0060004)	2.73813246
64	positive regulation of developmental pigmentation (GO:0048087)	2.72054604
65	recombinational repair (GO:0000725)	2.70811129
66	double-strand break repair via homologous recombination (GO:0000724)	2.69913695
67	kidney morphogenesis (GO:0060993)	2.69666439
68	epithelial cilium movement (GO:0003351)	2.68702223
69	ketone body metabolic process (GO:1902224)	2.68480240
70	respiratory chain complex IV assembly (GO:0008535)	2.67568689
71	mannosylation (GO:0097502)	2.66666488
72	synapsis (GO:0007129)	2.64795472
73	replication fork processing (GO:0031297)	2.63438250
74	multicellular organism reproduction (GO:0032504)	2.62476471
75	somite rostral/caudal axis specification (GO:0032525)	2.61288203
76	behavioral response to ethanol (GO:0048149)	2.60992107
77	tachykinin receptor signaling pathway (GO:0007217)	2.60024640
78	neural tube formation (GO:0001841)	2.58950026
79	organic cation transport (GO:0015695)	2.58395669
80	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.56588507
81	gamma-aminobutyric acid transport (GO:0015812)	2.53849702
82	male meiosis I (GO:0007141)	2.52682934
83	positive regulation of defense response to virus by host (GO:0002230)	2.51363671
84	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.50733349
85	regulation of hippo signaling (GO:0035330)	2.50193197
86	regulation of pigment cell differentiation (GO:0050932)	2.49540001
87	aspartate family amino acid catabolic process (GO:0009068)	2.48810156
88	regulation of action potential (GO:0098900)	2.48780022
89	cornea development in camera-type eye (GO:0061303)	2.48764413
90	aromatic amino acid family metabolic process (GO:0009072)	2.48582429
91	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	2.48227988
92	regulation of hexokinase activity (GO:1903299)	2.47176503
93	regulation of glucokinase activity (GO:0033131)	2.47176503
94	photoreceptor cell maintenance (GO:0045494)	2.46782037
95	retinal cone cell development (GO:0046549)	2.46147714
96	protein polyglutamylation (GO:0018095)	2.44090301
97	regulation of neurotransmitter uptake (GO:0051580)	2.43776535
98	sulfur compound transport (GO:0072348)	2.43535421
99	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.42920160
100	cellular response to ATP (GO:0071318)	2.42309931

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.87539688
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.26494014
3	VDR_22108803_ChIP-Seq_LS180_Human	3.18191809
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.97966544
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.81950309
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.39512522
7	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.34968490
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.28460212
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.20461571
10	EZH2_22144423_ChIP-Seq_EOC_Human	2.14452422
11	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.12819567
12	P300_19829295_ChIP-Seq_ESCs_Human	2.11407266
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.05634137
14	AR_21572438_ChIP-Seq_LNCaP_Human	2.01428905
15	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.01317450
16	ER_23166858_ChIP-Seq_MCF-7_Human	2.00878719
17	EWS_26573619_Chip-Seq_HEK293_Human	1.99203154
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.93643125
19	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.90115759
20	FUS_26573619_Chip-Seq_HEK293_Human	1.89477727
21	TAF15_26573619_Chip-Seq_HEK293_Human	1.85538880
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.82456671
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.80119508
24	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.66644406
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.64983635
26	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.61326330
27	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.52092936
28	NANOG_19829295_ChIP-Seq_ESCs_Human	1.51739916
29	SOX2_19829295_ChIP-Seq_ESCs_Human	1.51739916
30	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.50750638
31	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.49992590
32	STAT3_23295773_ChIP-Seq_U87_Human	1.49747780
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.49367973
34	BCAT_22108803_ChIP-Seq_LS180_Human	1.48857641
35	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.47608200
36	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.47595494
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.47559533
38	AR_25329375_ChIP-Seq_VCAP_Human	1.47482112
39	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.46830774
40	CBP_20019798_ChIP-Seq_JUKART_Human	1.46830774
41	TCF4_23295773_ChIP-Seq_U87_Human	1.46161587
42	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.44923019
43	TP53_22573176_ChIP-Seq_HFKS_Human	1.44693430
44	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.44114243
45	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.43731746
46	SMAD4_21799915_ChIP-Seq_A2780_Human	1.42526313
47	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.42523790
48	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.42236092
49	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.36959067
50	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.36959067
51	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.36763835
52	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.36509570
53	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.33848750
54	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.33848750
55	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.33606997
56	TCF4_22108803_ChIP-Seq_LS180_Human	1.32204058
57	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.32080593
58	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.31647498
59	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.31593159
60	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.29898510
61	HOXB7_26014856_ChIP-Seq_BT474_Human	1.28763796
62	NCOR_22424771_ChIP-Seq_293T_Human	1.28157560
63	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.27353987
64	MYC_18940864_ChIP-ChIP_HL60_Human	1.27137951
65	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.25782860
66	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.25084723
67	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.23247831
68	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.23030095
69	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.21700078
70	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.20329928
71	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.19897541
72	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.19809951
73	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.18759844
74	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.18133695
75	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.17012034
76	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.16325796
77	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.15809347
78	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.14389132
79	REST_21632747_ChIP-Seq_MESCs_Mouse	1.14039019
80	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.12627830
81	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.11023855
82	RUNX2_22187159_ChIP-Seq_PCA_Human	1.09677873
83	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.08351239
84	CDX2_22108803_ChIP-Seq_LS180_Human	1.07547043
85	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.07291604
86	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.07216602
87	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.06243792
88	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.06082043
89	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.05955110
90	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.05693436
91	IRF1_19129219_ChIP-ChIP_H3396_Human	1.03110803
92	AR_20517297_ChIP-Seq_VCAP_Human	1.02331378
93	P53_22387025_ChIP-Seq_ESCs_Mouse	1.02106565
94	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.01033789
95	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.99566266
96	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.99387908
97	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.98583996
98	RNF2_27304074_Chip-Seq_NSC_Mouse	0.98531643
99	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.98357934
100	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.96717275

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	5.97816183
2	MP0003136_yellow_coat_color	4.44076337
3	MP0002653_abnormal_ependyma_morphology	4.15932131
4	MP0005171_absent_coat_pigmentation	3.32135404
5	MP0003646_muscle_fatigue	3.14717582
6	MP0003195_calcinosis	3.09698086
7	MP0000569_abnormal_digit_pigmentation	2.86759560
8	MP0002102_abnormal_ear_morphology	2.39803651
9	MP0003890_abnormal_embryonic-extraembry	2.18387419
10	MP0002938_white_spotting	2.14370097
11	MP0005551_abnormal_eye_electrophysiolog	2.14194943
12	MP0008877_abnormal_DNA_methylation	2.12689022
13	MP0004147_increased_porphyrin_level	2.10325657
14	MP0002138_abnormal_hepatobiliary_system	2.02495656
15	MP0002160_abnormal_reproductive_system	1.88976660
16	MP0001968_abnormal_touch/_nociception	1.87506022
17	MP0002876_abnormal_thyroid_physiology	1.85306754
18	MP0008875_abnormal_xenobiotic_pharmacok	1.83288254
19	MP0005174_abnormal_tail_pigmentation	1.82826794
20	MP0003045_fibrosis	1.77703516
21	MP0008872_abnormal_physiological_respon	1.74621728
22	MP0004043_abnormal_pH_regulation	1.72447280
23	MP0005645_abnormal_hypothalamus_physiol	1.71556342
24	MP0009745_abnormal_behavioral_response	1.67418200
25	MP0005075_abnormal_melanosome_morpholog	1.62557471
26	MP0000427_abnormal_hair_cycle	1.61396716
27	MP0009046_muscle_twitch	1.59595071
28	MP0006072_abnormal_retinal_apoptosis	1.57988340
29	MP0001984_abnormal_olfaction	1.57233255
30	MP0005646_abnormal_pituitary_gland	1.54266868
31	MP0001501_abnormal_sleep_pattern	1.51756694
32	MP0005253_abnormal_eye_physiology	1.51309673
33	MP0000372_irregular_coat_pigmentation	1.49864053
34	MP0005389_reproductive_system_phenotype	1.45716176
35	MP0004142_abnormal_muscle_tone	1.44495575
36	MP0002272_abnormal_nervous_system	1.44441333
37	MP0001986_abnormal_taste_sensitivity	1.40858504
38	MP0005085_abnormal_gallbladder_physiolo	1.37329049
39	MP0002736_abnormal_nociception_after	1.36672831
40	MP0006292_abnormal_olfactory_placode	1.35785479
41	MP0004885_abnormal_endolymph	1.34894614
42	MP0002095_abnormal_skin_pigmentation	1.33353828
43	MP0001486_abnormal_startle_reflex	1.31356758
44	MP0001485_abnormal_pinna_reflex	1.21798983
45	MP0002163_abnormal_gland_morphology	1.19759315
46	MP0004381_abnormal_hair_follicle	1.15998173
47	MP0003011_delayed_dark_adaptation	1.15367859
48	MP0002735_abnormal_chemical_nociception	1.14315530
49	MP0003879_abnormal_hair_cell	1.14228775
50	MP0006276_abnormal_autonomic_nervous	1.13376922
51	MP0005670_abnormal_white_adipose	1.13034762
52	MP0000631_abnormal_neuroendocrine_gland	1.12797231
53	MP0002928_abnormal_bile_duct	1.09952418
54	MP0004133_heterotaxia	1.09235522
55	MP0005084_abnormal_gallbladder_morpholo	1.08744893
56	MP0003787_abnormal_imprinting	1.08725392
57	MP0004145_abnormal_muscle_electrophysio	1.08561310
58	MP0001970_abnormal_pain_threshold	1.06950549
59	MP0003137_abnormal_impulse_conducting	1.06573162
60	MP0002064_seizures	1.05574357
61	MP0002733_abnormal_thermal_nociception	1.04796417
62	MP0003252_abnormal_bile_duct	1.04553986
63	MP0002277_abnormal_respiratory_mucosa	1.04340336
64	MP0002572_abnormal_emotion/affect_behav	1.00344577
65	MP0000015_abnormal_ear_pigmentation	0.97438119
66	MP0002638_abnormal_pupillary_reflex	0.97391944
67	MP0005379_endocrine/exocrine_gland_phen	0.96405346
68	MP0005410_abnormal_fertilization	0.94923524
69	MP0003880_abnormal_central_pattern	0.88769612
70	MP0003718_maternal_effect	0.88619268
71	MP0002751_abnormal_autonomic_nervous	0.88534522
72	MP0001529_abnormal_vocalization	0.84182451
73	MP0001764_abnormal_homeostasis	0.83499977
74	MP0003878_abnormal_ear_physiology	0.82976711
75	MP0005377_hearing/vestibular/ear_phenot	0.82976711
76	MP0002557_abnormal_social/conspecific_i	0.82299355
77	MP0004742_abnormal_vestibular_system	0.81875525
78	MP0005365_abnormal_bile_salt	0.80293114
79	MP0004924_abnormal_behavior	0.79894486
80	MP0005386_behavior/neurological_phenoty	0.79894486
81	MP0001905_abnormal_dopamine_level	0.79612195
82	MP0005195_abnormal_posterior_eye	0.78550197
83	MP0002168_other_aberrant_phenotype	0.78164979
84	MP0001919_abnormal_reproductive_system	0.76567901
85	MP0003698_abnormal_male_reproductive	0.76491686
86	MP0001324_abnormal_eye_pigmentation	0.74498227
87	MP0001929_abnormal_gametogenesis	0.74376592
88	MP0006036_abnormal_mitochondrial_physio	0.74144229
89	MP0002210_abnormal_sex_determination	0.73090904
90	MP0000026_abnormal_inner_ear	0.72500778
91	MP0002234_abnormal_pharynx_morphology	0.71734548
92	MP0002229_neurodegeneration	0.70990654
93	MP0002254_reproductive_system_inflammat	0.70554289
94	MP0002752_abnormal_somatic_nervous	0.70249146
95	MP0005395_other_phenotype	0.69138699
96	MP0005332_abnormal_amino_acid	0.69074257
97	MP0000749_muscle_degeneration	0.68781261
98	MP0000230_abnormal_systemic_arterial	0.68396680
99	MP0002067_abnormal_sensory_capabilities	0.67917131
100	MP0002693_abnormal_pancreas_physiology	0.66413151

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	5.25850088
2	Pancreatic fibrosis (HP:0100732)	4.02946127
3	Congenital stationary night blindness (HP:0007642)	3.95369294
4	True hermaphroditism (HP:0010459)	3.72586045
5	Amelogenesis imperfecta (HP:0000705)	3.68024918
6	Molar tooth sign on MRI (HP:0002419)	3.67922910
7	Abnormality of midbrain morphology (HP:0002418)	3.67922910
8	Pendular nystagmus (HP:0012043)	3.57549313
9	Abnormality of the renal cortex (HP:0011035)	3.55257624
10	Nephronophthisis (HP:0000090)	3.49586770
11	Focal motor seizures (HP:0011153)	3.42756561
12	Abnormality of the renal medulla (HP:0100957)	3.21828556
13	Type II lissencephaly (HP:0007260)	3.02840374
14	Inability to walk (HP:0002540)	3.00246131
15	Abolished electroretinogram (ERG) (HP:0000550)	2.94269760
16	Tubular atrophy (HP:0000092)	2.92941075
17	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.88611745
18	Cystic liver disease (HP:0006706)	2.88256951
19	Abnormal rod and cone electroretinograms (HP:0008323)	2.87673883
20	Attenuation of retinal blood vessels (HP:0007843)	2.82933185
21	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.72561651
22	Abnormality of alanine metabolism (HP:0010916)	2.72561651
23	Hyperalaninemia (HP:0003348)	2.72561651
24	Chronic hepatic failure (HP:0100626)	2.69632478
25	Progressive inability to walk (HP:0002505)	2.67481619
26	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.66492333
27	Polydipsia (HP:0001959)	2.53766776
28	Abnormal drinking behavior (HP:0030082)	2.53766776
29	Decreased circulating renin level (HP:0003351)	2.47521179
30	Gaze-evoked nystagmus (HP:0000640)	2.43689591
31	Colon cancer (HP:0003003)	2.43521248
32	Parakeratosis (HP:0001036)	2.37931273
33	Medial flaring of the eyebrow (HP:0010747)	2.36467702
34	Dialeptic seizures (HP:0011146)	2.35567313
35	Increased corneal curvature (HP:0100692)	2.35305098
36	Keratoconus (HP:0000563)	2.35305098
37	Hyperventilation (HP:0002883)	2.32445849
38	Large for gestational age (HP:0001520)	2.31070268
39	Furrowed tongue (HP:0000221)	2.27767641
40	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.26853060
41	Aplastic anemia (HP:0001915)	2.24036264
42	Cerebellar dysplasia (HP:0007033)	2.21519030
43	Congenital hepatic fibrosis (HP:0002612)	2.16574977
44	Clumsiness (HP:0002312)	2.15861958
45	Decreased central vision (HP:0007663)	2.14972320
46	Abnormal biliary tract physiology (HP:0012439)	2.14833447
47	Bile duct proliferation (HP:0001408)	2.14833447
48	Anencephaly (HP:0002323)	2.11961276
49	Sclerocornea (HP:0000647)	2.11127163
50	Abnormality of macular pigmentation (HP:0008002)	2.06065941
51	Stomach cancer (HP:0012126)	2.05931020
52	Renal cortical cysts (HP:0000803)	2.05056963
53	Congenital sensorineural hearing impairment (HP:0008527)	2.03947397
54	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.01977417
55	Focal seizures (HP:0007359)	2.01871779
56	Polyuria (HP:0000103)	2.01688461
57	Lissencephaly (HP:0001339)	2.00258451
58	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.00211816
59	Absent/shortened dynein arms (HP:0200106)	2.00211816
60	Progressive cerebellar ataxia (HP:0002073)	1.98033733
61	Intestinal atresia (HP:0011100)	1.95356507
62	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.95322716
63	Male pseudohermaphroditism (HP:0000037)	1.94991744
64	Chorioretinal atrophy (HP:0000533)	1.92939523
65	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.92902345
66	Hypoplasia of the fovea (HP:0007750)	1.92902345
67	Abnormality of the pons (HP:0007361)	1.89553064
68	Hypoplasia of the pons (HP:0012110)	1.86841963
69	Congenital, generalized hypertrichosis (HP:0004540)	1.86051490
70	Severe visual impairment (HP:0001141)	1.85729631
71	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.85625244
72	Genetic anticipation (HP:0003743)	1.83901132
73	Optic nerve hypoplasia (HP:0000609)	1.83720715
74	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.83030448
75	Hypothermia (HP:0002045)	1.77927052
76	Abnormality of the ileum (HP:0001549)	1.77788728
77	Ketoacidosis (HP:0001993)	1.77182584
78	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.76784981
79	Gait imbalance (HP:0002141)	1.75744063
80	Broad-based gait (HP:0002136)	1.74050111
81	Congenital primary aphakia (HP:0007707)	1.72784480
82	Hypoalbuminemia (HP:0003073)	1.72553004
83	Abnormal albumin level (HP:0012116)	1.72553004
84	Retinitis pigmentosa (HP:0000510)	1.72232541
85	Genital tract atresia (HP:0001827)	1.71484473
86	3-Methylglutaconic aciduria (HP:0003535)	1.71432069
87	Pancreatic islet-cell hyperplasia (HP:0004510)	1.70962872
88	Bony spicule pigmentary retinopathy (HP:0007737)	1.70780747
89	Increased CSF lactate (HP:0002490)	1.70605178
90	Acute necrotizing encephalopathy (HP:0006965)	1.70398842
91	Meckel diverticulum (HP:0002245)	1.69638708
92	Neoplasm of the adrenal cortex (HP:0100641)	1.69347063
93	Severe muscular hypotonia (HP:0006829)	1.68956405
94	Hyperglycinuria (HP:0003108)	1.68533494
95	Postaxial foot polydactyly (HP:0001830)	1.67887382
96	Methylmalonic acidemia (HP:0002912)	1.67543778
97	Mitochondrial inheritance (HP:0001427)	1.66596609
98	Nephrogenic diabetes insipidus (HP:0009806)	1.66011408
99	Acute encephalopathy (HP:0006846)	1.65791230
100	Ketosis (HP:0001946)	1.65687120

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.48993657
2	LATS1	4.89434843
3	STK38L	4.09500226
4	ZAK	3.64629614
5	PINK1	3.13197031
6	ADRBK2	3.06739446
7	BMPR1B	2.99927851
8	ACVR1B	2.60056072
9	WNK3	2.33592054
10	GRK1	2.28934683
11	MAP4K2	2.02451830
12	NUAK1	2.01560568
13	STK3	1.93979669
14	EIF2AK3	1.82937501
15	TAOK3	1.66579989
16	LATS2	1.62552333
17	TLK1	1.55594262
18	WNK4	1.51373330
19	TXK	1.48084692
20	INSRR	1.47370508
21	NLK	1.42802361
22	VRK2	1.34595176
23	DAPK2	1.27989992
24	OXSR1	1.25607030
25	MAPK13	1.22669903
26	CASK	1.17483606
27	TNIK	1.09840774
28	TRIM28	1.07900598
29	TAF1	1.05745206
30	STK38	1.02466812
31	STK39	1.01631396
32	VRK1	1.01068910
33	CSNK1A1L	1.00722173
34	PRKD3	0.99634454
35	ADRBK1	0.99261081
36	MAP3K4	0.95947825
37	MST4	0.93752468
38	MAP2K2	0.92364947
39	NEK2	0.90142955
40	WEE1	0.85651767
41	PAK3	0.83572039
42	PRKCE	0.82756414
43	PHKG1	0.81435798
44	PHKG2	0.81435798
45	MKNK2	0.80364467
46	TGFBR1	0.78999403
47	CSNK1G1	0.78846558
48	CSNK1G3	0.77644374
49	CSNK1G2	0.77075918
50	MUSK	0.75357874
51	TIE1	0.74391974
52	BRSK2	0.69043593
53	PRKCG	0.67720520
54	PLK2	0.65884821
55	PRKAA2	0.65299265
56	FGFR2	0.65046611
57	PLK3	0.62829996
58	DYRK2	0.59539910
59	MELK	0.58749707
60	STK11	0.56170436
61	OBSCN	0.53845825
62	TNK2	0.51850197
63	ERBB3	0.51582230
64	CAMKK2	0.50570789
65	GRK7	0.46959670
66	MAP2K7	0.46530417
67	NME1	0.44921148
68	PRKCQ	0.44737935
69	PLK1	0.43798812
70	PTK2B	0.43722232
71	EIF2AK2	0.43718062
72	MARK1	0.43663286
73	PRKCI	0.43269296
74	PLK4	0.43168180
75	FER	0.42781041
76	MAPKAPK5	0.42096610
77	CSNK1A1	0.41462448
78	CHEK2	0.41184211
79	MAPKAPK3	0.39396047
80	IRAK1	0.39122708
81	CSNK1D	0.38053408
82	BCR	0.37358190
83	CAMK2A	0.37095547
84	NTRK3	0.35580857
85	IKBKB	0.34800814
86	RPS6KA5	0.33861193
87	GRK5	0.33628906
88	TEC	0.33543707
89	PRKACA	0.33338766
90	PIK3CA	0.31658504
91	MARK3	0.31539444
92	BCKDK	0.31351168
93	ATR	0.30413224
94	ITK	0.30013204
95	BLK	0.29717521
96	MAP2K1	0.29482407
97	PRKCZ	0.29252296
98	MAP2K6	0.28890748
99	KIT	0.27235046
100	ABL1	0.25420971

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.74499554
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.26663372
3	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.97249002
4	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.80507532
5	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.44691082
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.41119749
7	Nicotine addiction_Homo sapiens_hsa05033	2.32156505
8	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.25557513
9	Selenocompound metabolism_Homo sapiens_hsa00450	2.15833892
10	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.09172812
11	Linoleic acid metabolism_Homo sapiens_hsa00591	2.08638271
12	Butanoate metabolism_Homo sapiens_hsa00650	2.04502972
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.98642796
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.94757986
15	Tryptophan metabolism_Homo sapiens_hsa00380	1.93098497
16	Basal transcription factors_Homo sapiens_hsa03022	1.83432452
17	Homologous recombination_Homo sapiens_hsa03440	1.80947807
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.80852782
19	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.67839925
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.67317483
21	Protein export_Homo sapiens_hsa03060	1.66812502
22	Oxidative phosphorylation_Homo sapiens_hsa00190	1.66742490
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.64651136
24	Taste transduction_Homo sapiens_hsa04742	1.53844777
25	Ether lipid metabolism_Homo sapiens_hsa00565	1.49767040
26	Caffeine metabolism_Homo sapiens_hsa00232	1.44997726
27	Morphine addiction_Homo sapiens_hsa05032	1.41963079
28	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.40766874
29	RNA polymerase_Homo sapiens_hsa03020	1.35111321
30	One carbon pool by folate_Homo sapiens_hsa00670	1.33499672
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.32859834
32	Sphingolipid metabolism_Homo sapiens_hsa00600	1.31988673
33	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.27354626
34	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.25960475
35	Olfactory transduction_Homo sapiens_hsa04740	1.21167997
36	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.18982700
37	Propanoate metabolism_Homo sapiens_hsa00640	1.15865138
38	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.15107721
39	ABC transporters_Homo sapiens_hsa02010	1.12740004
40	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.10474768
41	Sulfur metabolism_Homo sapiens_hsa00920	1.09736465
42	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.08866809
43	RNA degradation_Homo sapiens_hsa03018	1.06846465
44	Parkinsons disease_Homo sapiens_hsa05012	1.06229928
45	GABAergic synapse_Homo sapiens_hsa04727	1.03792592
46	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.96962801
47	Peroxisome_Homo sapiens_hsa04146	0.95422881
48	Chemical carcinogenesis_Homo sapiens_hsa05204	0.95181451
49	Collecting duct acid secretion_Homo sapiens_hsa04966	0.91662495
50	Insulin secretion_Homo sapiens_hsa04911	0.91441946
51	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.89771184
52	Retinol metabolism_Homo sapiens_hsa00830	0.81445846
53	Serotonergic synapse_Homo sapiens_hsa04726	0.80091883
54	Histidine metabolism_Homo sapiens_hsa00340	0.79651667
55	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.78200155
56	beta-Alanine metabolism_Homo sapiens_hsa00410	0.75523730
57	Asthma_Homo sapiens_hsa05310	0.74786764
58	Calcium signaling pathway_Homo sapiens_hsa04020	0.74611062
59	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.74505033
60	Glutamatergic synapse_Homo sapiens_hsa04724	0.74004873
61	Regulation of autophagy_Homo sapiens_hsa04140	0.69037212
62	Glycerolipid metabolism_Homo sapiens_hsa00561	0.68456731
63	Huntingtons disease_Homo sapiens_hsa05016	0.66929059
64	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.66289332
65	Type I diabetes mellitus_Homo sapiens_hsa04940	0.65744428
66	Circadian entrainment_Homo sapiens_hsa04713	0.64628566
67	Purine metabolism_Homo sapiens_hsa00230	0.60439947
68	Primary immunodeficiency_Homo sapiens_hsa05340	0.60381625
69	Non-homologous end-joining_Homo sapiens_hsa03450	0.58574327
70	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.57766719
71	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.57674323
72	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.57383721
73	Alzheimers disease_Homo sapiens_hsa05010	0.57114750
74	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.56600297
75	Metabolic pathways_Homo sapiens_hsa01100	0.55914135
76	Salivary secretion_Homo sapiens_hsa04970	0.54695030
77	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.53934179
78	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.52540832
79	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.51871204
80	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.51495620
81	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.50796400
82	Sulfur relay system_Homo sapiens_hsa04122	0.47660421
83	Proteasome_Homo sapiens_hsa03050	0.47316620
84	Fat digestion and absorption_Homo sapiens_hsa04975	0.46631153
85	Cardiac muscle contraction_Homo sapiens_hsa04260	0.46567612
86	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.45638118
87	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.43471437
88	Circadian rhythm_Homo sapiens_hsa04710	0.43401568
89	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.41699962
90	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.40755318
91	Fatty acid degradation_Homo sapiens_hsa00071	0.40394581
92	Mineral absorption_Homo sapiens_hsa04978	0.40253922
93	Pyrimidine metabolism_Homo sapiens_hsa00240	0.38755625
94	Rheumatoid arthritis_Homo sapiens_hsa05323	0.35795112
95	Folate biosynthesis_Homo sapiens_hsa00790	0.34654886
96	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.32832683
97	Allograft rejection_Homo sapiens_hsa05330	0.32158207
98	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.31009688
99	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.30556838
100	cAMP signaling pathway_Homo sapiens_hsa04024	0.30456499

ZNF969P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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