ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	centriole replication (GO:0007099)	4.89118274
2	piRNA metabolic process (GO:0034587)	4.82895095
3	synapsis (GO:0007129)	4.66958567
4	DNA double-strand break processing (GO:0000729)	4.53800656
5	male meiosis I (GO:0007141)	4.50336329
6	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	4.46273700
7	somatic hypermutation of immunoglobulin genes (GO:0016446)	4.41391794
8	somatic diversification of immune receptors via somatic mutation (GO:0002566)	4.41391794
9	regulation of retinoic acid receptor signaling pathway (GO:0048385)	4.27205959
10	replication fork processing (GO:0031297)	4.12003881
11	regulation of meiosis I (GO:0060631)	3.92117710
12	male meiosis (GO:0007140)	3.83294965
13	regulation of mitotic spindle checkpoint (GO:1903504)	3.74715386
14	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.74715386
15	centriole assembly (GO:0098534)	3.72258359
16	meiosis I (GO:0007127)	3.68549696
17	rRNA modification (GO:0000154)	3.64924770
18	regulation of centriole replication (GO:0046599)	3.64691442
19	sperm motility (GO:0030317)	3.64244485
20	reciprocal DNA recombination (GO:0035825)	3.58667438
21	reciprocal meiotic recombination (GO:0007131)	3.58667438
22	DNA deamination (GO:0045006)	3.55541986
23	DNA catabolic process, exonucleolytic (GO:0000738)	3.49343898
24	double-strand break repair via homologous recombination (GO:0000724)	3.45682180
25	chromatin remodeling at centromere (GO:0031055)	3.44206116
26	recombinational repair (GO:0000725)	3.43064891
27	protein polyglutamylation (GO:0018095)	3.37679307
28	rRNA methylation (GO:0031167)	3.37373059
29	histone exchange (GO:0043486)	3.34063178
30	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.33602928
31	resolution of meiotic recombination intermediates (GO:0000712)	3.29759814
32	acrosome reaction (GO:0007340)	3.29317651
33	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.28939874
34	response to pheromone (GO:0019236)	3.28877703
35	protein localization to cilium (GO:0061512)	3.25435685
36	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.24038971
37	CENP-A containing nucleosome assembly (GO:0034080)	3.23860083
38	protein K6-linked ubiquitination (GO:0085020)	3.21561388
39	intraciliary transport (GO:0042073)	3.18162985
40	microtubule depolymerization (GO:0007019)	3.17598584
41	regulation of DNA endoreduplication (GO:0032875)	3.16100044
42	proteasome assembly (GO:0043248)	3.14344327
43	seminiferous tubule development (GO:0072520)	3.10881936
44	meiotic nuclear division (GO:0007126)	3.07831599
45	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.06065460
46	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.06065460
47	DNA methylation involved in gamete generation (GO:0043046)	3.03951968
48	chromosome organization involved in meiosis (GO:0070192)	2.99065867
49	kinetochore assembly (GO:0051382)	2.98716936
50	mismatch repair (GO:0006298)	2.94522174
51	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.92642977
52	spermatid development (GO:0007286)	2.89873473
53	sister chromatid cohesion (GO:0007062)	2.89577962
54	mitotic sister chromatid cohesion (GO:0007064)	2.89471166
55	regulation of centrosome duplication (GO:0010824)	2.85590466
56	multicellular organism reproduction (GO:0032504)	2.83295737
57	protein complex biogenesis (GO:0070271)	2.82400387
58	regulation of centrosome cycle (GO:0046605)	2.82076437
59	cell wall macromolecule catabolic process (GO:0016998)	2.81958535
60	meiotic cell cycle process (GO:1903046)	2.79143747
61	photoreceptor cell maintenance (GO:0045494)	2.78937748
62	kinetochore organization (GO:0051383)	2.77288411
63	ubiquinone biosynthetic process (GO:0006744)	2.77106270
64	pseudouridine synthesis (GO:0001522)	2.75990109
65	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.75091417
66	RNA destabilization (GO:0050779)	2.74538955
67	mannosylation (GO:0097502)	2.72037247
68	cell wall macromolecule metabolic process (GO:0044036)	2.69570357
69	respiratory chain complex IV assembly (GO:0008535)	2.69137444
70	meiotic chromosome segregation (GO:0045132)	2.68562079
71	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.67597834
72	NADH dehydrogenase complex assembly (GO:0010257)	2.67597834
73	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.67597834
74	ubiquinone metabolic process (GO:0006743)	2.66930408
75	platelet dense granule organization (GO:0060155)	2.66319848
76	positive regulation of prostaglandin secretion (GO:0032308)	2.65232968
77	double-strand break repair (GO:0006302)	2.64120580
78	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.62403117
79	mitochondrial respiratory chain complex assembly (GO:0033108)	2.60783530
80	sperm-egg recognition (GO:0035036)	2.60766043
81	meiotic cell cycle (GO:0051321)	2.59497309
82	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.58740180
83	adenosine metabolic process (GO:0046085)	2.57612196
84	DNA recombination (GO:0006310)	2.57036236
85	regulation of helicase activity (GO:0051095)	2.55725118
86	detection of light stimulus involved in sensory perception (GO:0050962)	2.55269190
87	detection of light stimulus involved in visual perception (GO:0050908)	2.55269190
88	epithelial cilium movement (GO:0003351)	2.54928051
89	DNA ligation (GO:0006266)	2.53014815
90	prenylation (GO:0097354)	2.52763816
91	protein prenylation (GO:0018342)	2.52763816
92	establishment of protein localization to Golgi (GO:0072600)	2.49950245
93	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.48280450
94	chaperone-mediated protein transport (GO:0072321)	2.46583952
95	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.45681931
96	regulation of translation, ncRNA-mediated (GO:0045974)	2.45681931
97	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.45681931
98	single strand break repair (GO:0000012)	2.45340623
99	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.44271525
100	somatic diversification of immunoglobulins (GO:0016445)	2.44155768

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.30168373
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.25312669
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.11065635
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.07635297
5	E2F7_22180533_ChIP-Seq_HELA_Human	2.98577642
6	VDR_22108803_ChIP-Seq_LS180_Human	2.95799777
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.89386018
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.88501209
9	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.66184177
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.63399062
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.59288074
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.34100013
13	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.32051100
14	FUS_26573619_Chip-Seq_HEK293_Human	2.22861900
15	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.19786168
16	TAF15_26573619_Chip-Seq_HEK293_Human	2.16939539
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.14175988
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.11833596
19	EWS_26573619_Chip-Seq_HEK293_Human	2.03412579
20	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.00187808
21	GBX2_23144817_ChIP-Seq_PC3_Human	1.93966807
22	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.88452835
23	P300_19829295_ChIP-Seq_ESCs_Human	1.85086393
24	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.83868886
25	ELK1_19687146_ChIP-ChIP_HELA_Human	1.83741056
26	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.83588621
27	VDR_23849224_ChIP-Seq_CD4+_Human	1.70259016
28	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.68993610
29	IRF1_19129219_ChIP-ChIP_H3396_Human	1.65407629
30	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.62456341
31	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.59290520
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.51759365
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.51064344
34	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.50468681
35	CBP_20019798_ChIP-Seq_JUKART_Human	1.49710685
36	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.49710685
37	ER_23166858_ChIP-Seq_MCF-7_Human	1.46506729
38	MYC_18940864_ChIP-ChIP_HL60_Human	1.44079388
39	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.41832319
40	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.41523197
41	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.40960227
42	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.40882889
43	NANOG_19829295_ChIP-Seq_ESCs_Human	1.40045708
44	SOX2_19829295_ChIP-Seq_ESCs_Human	1.40045708
45	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.36053734
46	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.32798289
47	FOXP3_21729870_ChIP-Seq_TREG_Human	1.32316701
48	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.30121277
49	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.28549447
50	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.27466880
51	BCAT_22108803_ChIP-Seq_LS180_Human	1.26838323
52	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.24992582
53	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.23852984
54	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.23547225
55	SMAD4_21799915_ChIP-Seq_A2780_Human	1.23480554
56	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.21887165
57	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.21887165
58	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.21607004
59	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.21489283
60	TCF4_22108803_ChIP-Seq_LS180_Human	1.21394157
61	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.20655416
62	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.19330347
63	STAT3_23295773_ChIP-Seq_U87_Human	1.19204795
64	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.18711110
65	AR_25329375_ChIP-Seq_VCAP_Human	1.18266814
66	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.18205336
67	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.16508151
68	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.16408691
69	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.15352754
70	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.15199794
71	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.14867379
72	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.14442285
73	HOXB7_26014856_ChIP-Seq_BT474_Human	1.12861204
74	ETV1_20927104_ChIP-Seq_GIST48_Human	1.12061788
75	TCF4_23295773_ChIP-Seq_U87_Human	1.11198458
76	CDX2_22108803_ChIP-Seq_LS180_Human	1.09169043
77	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.09005099
78	PHF8_20622853_ChIP-Seq_HELA_Human	1.08731512
79	RBPJ_21746931_ChIP-Seq_IB4_Human	1.07939262
80	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.07813498
81	* TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.07614227
82	NCOR_22424771_ChIP-Seq_293T_Human	1.06738644
83	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.05429371
84	RUNX2_22187159_ChIP-Seq_PCA_Human	1.03976608
85	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.03402130
86	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.02109709
87	HTT_18923047_ChIP-ChIP_STHdh_Human	1.01613388
88	AR_20517297_ChIP-Seq_VCAP_Human	1.01337020
89	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.01299320
90	NFYB_21822215_ChIP-Seq_K562_Human	1.00845246
91	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.97908880
92	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.97114336
93	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.96534918
94	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.96464142
95	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.96263130
96	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.93580039
97	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.92128663
98	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.92075351
99	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.91877096
100	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.91687229

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.90463551
2	MP0008058_abnormal_DNA_repair	3.11821955
3	MP0005410_abnormal_fertilization	2.99700762
4	MP0008057_abnormal_DNA_replication	2.93379205
5	MP0003718_maternal_effect	2.91324711
6	MP0010094_abnormal_chromosome_stability	2.90428031
7	MP0006292_abnormal_olfactory_placode	2.79091122
8	MP0005646_abnormal_pituitary_gland	2.75285038
9	MP0002837_dystrophic_cardiac_calcinosis	2.70129734
10	MP0003195_calcinosis	2.41903909
11	MP0009697_abnormal_copulation	2.24917517
12	MP0000372_irregular_coat_pigmentation	2.20503972
13	MP0001929_abnormal_gametogenesis	2.13117790
14	MP0002160_abnormal_reproductive_system	2.11677781
15	MP0002102_abnormal_ear_morphology	2.03365895
16	MP0006072_abnormal_retinal_apoptosis	2.02239749
17	MP0005075_abnormal_melanosome_morpholog	2.01885406
18	MP0005551_abnormal_eye_electrophysiolog	1.93113510
19	MP0001968_abnormal_touch/_nociception	1.93003417
20	MP0002736_abnormal_nociception_after	1.82552383
21	MP0002210_abnormal_sex_determination	1.78310260
22	MP0003698_abnormal_male_reproductive	1.73568265
23	MP0003693_abnormal_embryo_hatching	1.70248090
24	MP0000427_abnormal_hair_cycle	1.69893570
25	MP0001986_abnormal_taste_sensitivity	1.63517451
26	MP0000631_abnormal_neuroendocrine_gland	1.59702390
27	MP0005645_abnormal_hypothalamus_physiol	1.55663637
28	MP0005253_abnormal_eye_physiology	1.52412188
29	MP0001145_abnormal_male_reproductive	1.52365007
30	MP0002163_abnormal_gland_morphology	1.52013045
31	MP0005379_endocrine/exocrine_gland_phen	1.49638123
32	MP0000653_abnormal_sex_gland	1.49531344
33	MP0008872_abnormal_physiological_respon	1.48807388
34	MP0002938_white_spotting	1.42051134
35	MP0003011_delayed_dark_adaptation	1.38318900
36	MP0005389_reproductive_system_phenotype	1.36310097
37	MP0005085_abnormal_gallbladder_physiolo	1.35582485
38	MP0006054_spinal_hemorrhage	1.29744381
39	MP0010368_abnormal_lymphatic_system	1.29684622
40	MP0000383_abnormal_hair_follicle	1.29005426
41	MP0008995_early_reproductive_senescence	1.27744493
42	MP0009384_cardiac_valve_regurgitation	1.25957942
43	MP0003646_muscle_fatigue	1.25645186
44	MP0001485_abnormal_pinna_reflex	1.24006986
45	MP0005084_abnormal_gallbladder_morpholo	1.23303129
46	MP0003136_yellow_coat_color	1.20960012
47	MP0003111_abnormal_nucleus_morphology	1.18598809
48	MP0002751_abnormal_autonomic_nervous	1.17121482
49	MP0003806_abnormal_nucleotide_metabolis	1.16255432
50	MP0005670_abnormal_white_adipose	1.15862877
51	MP0004885_abnormal_endolymph	1.14954279
52	MP0002234_abnormal_pharynx_morphology	1.13969098
53	MP0001486_abnormal_startle_reflex	1.12786904
54	MP0004215_abnormal_myocardial_fiber	1.12414835
55	MP0003943_abnormal_hepatobiliary_system	1.10417288
56	MP0003880_abnormal_central_pattern	1.10210919
57	MP0000013_abnormal_adipose_tissue	1.08246421
58	MP0002254_reproductive_system_inflammat	1.04469322
59	MP0003077_abnormal_cell_cycle	0.98977670
60	MP0003786_premature_aging	0.98578863
61	MP0001119_abnormal_female_reproductive	0.97201271
62	MP0005395_other_phenotype	0.96969093
63	MP0003123_paternal_imprinting	0.96162757
64	MP0004147_increased_porphyrin_level	0.96124710
65	MP0001764_abnormal_homeostasis	0.95566819
66	MP0001984_abnormal_olfaction	0.95456667
67	MP0003121_genomic_imprinting	0.95079515
68	MP0002161_abnormal_fertility/fecundity	0.93609672
69	MP0004043_abnormal_pH_regulation	0.92918637
70	MP0002735_abnormal_chemical_nociception	0.92898541
71	MP0008932_abnormal_embryonic_tissue	0.92135549
72	MP0009745_abnormal_behavioral_response	0.91134857
73	MP0001293_anophthalmia	0.91052857
74	MP0005174_abnormal_tail_pigmentation	0.89482906
75	MP0006276_abnormal_autonomic_nervous	0.89446417
76	MP0002272_abnormal_nervous_system	0.85360578
77	MP0002277_abnormal_respiratory_mucosa	0.84196879
78	MP0006036_abnormal_mitochondrial_physio	0.84123997
79	MP0001963_abnormal_hearing_physiology	0.81052362
80	MP0009046_muscle_twitch	0.80091670
81	MP0002638_abnormal_pupillary_reflex	0.79870775
82	MP0004957_abnormal_blastocyst_morpholog	0.79848891
83	MP0001177_atelectasis	0.79363499
84	MP0002127_abnormal_cardiovascular_syste	0.77908176
85	MP0003119_abnormal_digestive_system	0.76687863
86	MP0003936_abnormal_reproductive_system	0.76247129
87	MP0008007_abnormal_cellular_replicative	0.76033253
88	MP0003186_abnormal_redox_activity	0.75899049
89	MP0010678_abnormal_skin_adnexa	0.75376718
90	MP0001919_abnormal_reproductive_system	0.74367976
91	MP0006035_abnormal_mitochondrial_morpho	0.73192632
92	MP0000647_abnormal_sebaceous_gland	0.71428033
93	MP0001666_abnormal_nutrient_absorption	0.71326653
94	MP0010307_abnormal_tumor_latency	0.69581107
95	MP0008789_abnormal_olfactory_epithelium	0.69211550
96	MP0008875_abnormal_xenobiotic_pharmacok	0.68691645
97	MP0002734_abnormal_mechanical_nocicepti	0.67741448
98	MP0000516_abnormal_urinary_system	0.66424748
99	MP0005367_renal/urinary_system_phenotyp	0.66424748
100	MP0001188_hyperpigmentation	0.63853408

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Tubulointerstitial nephritis (HP:0001970)	4.77922673
2	Pancreatic cysts (HP:0001737)	3.52921263
3	Pancreatic fibrosis (HP:0100732)	3.49905117
4	Chronic hepatic failure (HP:0100626)	3.34018512
5	True hermaphroditism (HP:0010459)	3.22397780
6	Nephronophthisis (HP:0000090)	3.21747014
7	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.08350756
8	Molar tooth sign on MRI (HP:0002419)	2.97256714
9	Abnormality of midbrain morphology (HP:0002418)	2.97256714
10	Abnormality of macular pigmentation (HP:0008002)	2.93052056
11	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.90499297
12	Amyotrophic lateral sclerosis (HP:0007354)	2.86340083
13	Chromsome breakage (HP:0040012)	2.84502897
14	Meckel diverticulum (HP:0002245)	2.83544622
15	Abnormality of the ileum (HP:0001549)	2.77122308
16	Volvulus (HP:0002580)	2.72412278
17	Broad distal phalanx of finger (HP:0009836)	2.68529276
18	Abnormality of the renal medulla (HP:0100957)	2.60367499
19	Small hand (HP:0200055)	2.53192156
20	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.50528760
21	Postaxial foot polydactyly (HP:0001830)	2.46940455
22	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.45280462
23	Pendular nystagmus (HP:0012043)	2.37032400
24	Carpal bone hypoplasia (HP:0001498)	2.35783050
25	Clubbing of toes (HP:0100760)	2.33013036
26	Hyperglycinuria (HP:0003108)	2.32842686
27	Mitochondrial inheritance (HP:0001427)	2.30596618
28	Abnormality of the preputium (HP:0100587)	2.30315972
29	Abnormality of the renal cortex (HP:0011035)	2.30049263
30	Attenuation of retinal blood vessels (HP:0007843)	2.29203327
31	Abnormality of chromosome stability (HP:0003220)	2.28434363
32	Abnormality of the labia minora (HP:0012880)	2.28056754
33	Medial flaring of the eyebrow (HP:0010747)	2.26394726
34	Abnormal rod and cone electroretinograms (HP:0008323)	2.25652397
35	Type II lissencephaly (HP:0007260)	2.24925475
36	Increased CSF lactate (HP:0002490)	2.23106920
37	Sclerocornea (HP:0000647)	2.22016334
38	Short tibia (HP:0005736)	2.19655934
39	Increased hepatocellular lipid droplets (HP:0006565)	2.18496862
40	Acute necrotizing encephalopathy (HP:0006965)	2.18180712
41	Lipid accumulation in hepatocytes (HP:0006561)	2.18156620
42	Tubulointerstitial abnormality (HP:0001969)	2.16878143
43	Male pseudohermaphroditism (HP:0000037)	2.15648872
44	Congenital stationary night blindness (HP:0007642)	2.11390221
45	Cystic liver disease (HP:0006706)	2.11296080
46	Severe visual impairment (HP:0001141)	2.09785657
47	Absent/shortened dynein arms (HP:0200106)	2.08926486
48	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.08926486
49	Sloping forehead (HP:0000340)	2.08574995
50	Type 2 muscle fiber atrophy (HP:0003554)	2.05159534
51	Hypoplasia of the fovea (HP:0007750)	2.04909395
52	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.04909395
53	Absent thumb (HP:0009777)	2.03088382
54	Renal Fanconi syndrome (HP:0001994)	2.01002959
55	Gaze-evoked nystagmus (HP:0000640)	1.99839445
56	Hip dysplasia (HP:0001385)	1.99414626
57	Acute encephalopathy (HP:0006846)	1.99083176
58	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.98850675
59	Abnormality of the pons (HP:0007361)	1.97951828
60	Hypoplasia of the pons (HP:0012110)	1.97900333
61	Astigmatism (HP:0000483)	1.97389391
62	Abnormality of lateral ventricle (HP:0030047)	1.96517443
63	Small intestinal stenosis (HP:0012848)	1.95259976
64	Duodenal stenosis (HP:0100867)	1.95259976
65	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.94838962
66	Progressive macrocephaly (HP:0004481)	1.94127092
67	Abnormality of the renal collecting system (HP:0004742)	1.93331474
68	Abnormality of the fovea (HP:0000493)	1.92454302
69	Hepatic necrosis (HP:0002605)	1.88665215
70	Abnormality of urine glucose concentration (HP:0011016)	1.86375416
71	Glycosuria (HP:0003076)	1.86375416
72	Abnormal mitochondria in muscle tissue (HP:0008316)	1.85058262
73	Hypothermia (HP:0002045)	1.83759767
74	Hepatocellular necrosis (HP:0001404)	1.83487841
75	Ectopic kidney (HP:0000086)	1.81765858
76	Anencephaly (HP:0002323)	1.81529374
77	Bony spicule pigmentary retinopathy (HP:0007737)	1.81524339
78	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.81119827
79	Optic nerve hypoplasia (HP:0000609)	1.80952150
80	Renal cortical cysts (HP:0000803)	1.80815124
81	Hyperglycinemia (HP:0002154)	1.80555828
82	Abnormal spermatogenesis (HP:0008669)	1.79814523
83	Colon cancer (HP:0003003)	1.79679644
84	Azoospermia (HP:0000027)	1.79049926
85	Median cleft lip (HP:0000161)	1.78952022
86	Postaxial hand polydactyly (HP:0001162)	1.78443448
87	Febrile seizures (HP:0002373)	1.77387080
88	Decreased central vision (HP:0007663)	1.76234184
89	Cone-rod dystrophy (HP:0000548)	1.75306515
90	Abnormality of the duodenum (HP:0002246)	1.74811579
91	Cutaneous finger syndactyly (HP:0010554)	1.74589370
92	Abolished electroretinogram (ERG) (HP:0000550)	1.73310555
93	Increased serum lactate (HP:0002151)	1.70821903
94	Triphalangeal thumb (HP:0001199)	1.70002669
95	Abnormality of the carotid arteries (HP:0005344)	1.68322623
96	Abnormality of serine family amino acid metabolism (HP:0010894)	1.67543938
97	Abnormality of glycine metabolism (HP:0010895)	1.67543938
98	Rhabdomyosarcoma (HP:0002859)	1.67104990
99	Abnormal respiratory motile cilium physiology (HP:0012261)	1.66676944
100	Oligohydramnios (HP:0001562)	1.66520812

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.95226196
2	VRK2	3.12825619
3	EIF2AK3	2.99738591
4	ACVR1B	2.93379148
5	NUAK1	2.91831863
6	MAP4K2	2.76573779
7	ZAK	2.75412368
8	PLK4	2.73163706
9	WNK3	2.71923608
10	STK39	2.51918262
11	BMPR1B	2.43002537
12	OXSR1	2.39528053
13	MST4	2.27686088
14	VRK1	2.05668000
15	INSRR	2.00932079
16	PNCK	1.82101791
17	TRIM28	1.75165563
18	CDC7	1.72817069
19	PLK3	1.64410237
20	BRSK2	1.63514199
21	WEE1	1.60375027
22	TTK	1.56005210
23	TSSK6	1.55707772
24	SRPK1	1.50038014
25	MKNK2	1.31297176
26	ADRBK2	1.30532481
27	GRK1	1.30483064
28	MKNK1	1.24640912
29	MAPK13	1.16626960
30	PLK1	1.14511548
31	NEK1	1.14398701
32	KIT	1.11413669
33	DYRK2	1.10140833
34	MUSK	1.09957052
35	BUB1	1.07188107
36	TAF1	1.05529873
37	PLK2	1.05243403
38	EIF2AK2	1.01529247
39	EPHA4	0.91738965
40	STK38L	0.91499031
41	TIE1	0.90674689
42	BRD4	0.88678861
43	CASK	0.87899906
44	PBK	0.82961605
45	PRKCE	0.82600857
46	PHKG2	0.81999817
47	PHKG1	0.81999817
48	AKT3	0.80459302
49	MAPKAPK5	0.80364924
50	TEC	0.78900222
51	MAPKAPK3	0.77749645
52	MAP3K4	0.77384443
53	BCKDK	0.76316922
54	FGFR2	0.75623695
55	STK3	0.74714045
56	STK16	0.73767561
57	CCNB1	0.71593514
58	CHEK2	0.71098106
59	KDR	0.70395671
60	EPHA3	0.70217784
61	ATR	0.69850295
62	FLT3	0.67712998
63	PAK3	0.66612753
64	FER	0.66190955
65	TLK1	0.63978974
66	PRKCI	0.62177593
67	ATM	0.61167510
68	EIF2AK1	0.60617229
69	PINK1	0.57169413
70	CSNK1G1	0.56884787
71	BRAF	0.55450654
72	TAOK3	0.55133583
73	TXK	0.52758223
74	CSNK1G2	0.52514334
75	CDK19	0.52472405
76	TNIK	0.51913559
77	TGFBR1	0.50624330
78	WNK1	0.50276956
79	WNK4	0.50024645
80	LATS1	0.48636693
81	TNK2	0.46098939
82	CDK7	0.44965474
83	CHEK1	0.44792043
84	CAMKK2	0.43861300
85	BRSK1	0.42910276
86	AURKB	0.41362149
87	PRKCG	0.41243161
88	PIK3CG	0.40557771
89	RPS6KB2	0.40451447
90	PRKCQ	0.39689046
91	RPS6KA5	0.38798951
92	GRK5	0.36915048
93	CSNK1D	0.36586463
94	ERBB3	0.36381396
95	CSNK1G3	0.35715067
96	MAP3K12	0.35452571
97	OBSCN	0.34648679
98	MAP3K2	0.34542172
99	PRKG1	0.32517115
100	AURKA	0.32188531

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Homologous recombination_Homo sapiens_hsa03440	3.37413675
2	Fanconi anemia pathway_Homo sapiens_hsa03460	2.96799152
3	Mismatch repair_Homo sapiens_hsa03430	2.84735056
4	Non-homologous end-joining_Homo sapiens_hsa03450	2.55900165
5	DNA replication_Homo sapiens_hsa03030	2.36370944
6	RNA polymerase_Homo sapiens_hsa03020	2.34074940
7	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.32758030
8	Basal transcription factors_Homo sapiens_hsa03022	2.28705139
9	Base excision repair_Homo sapiens_hsa03410	2.24772251
10	Proteasome_Homo sapiens_hsa03050	2.23209682
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.18795832
12	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.00444162
13	Oxidative phosphorylation_Homo sapiens_hsa00190	1.99861961
14	Butanoate metabolism_Homo sapiens_hsa00650	1.88723796
15	Parkinsons disease_Homo sapiens_hsa05012	1.82541955
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.82174591
17	Protein export_Homo sapiens_hsa03060	1.81168449
18	RNA degradation_Homo sapiens_hsa03018	1.79072886
19	Phototransduction_Homo sapiens_hsa04744	1.76836601
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.72389429
21	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.70043535
22	Nitrogen metabolism_Homo sapiens_hsa00910	1.65014810
23	RNA transport_Homo sapiens_hsa03013	1.63823583
24	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.62860555
25	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.57280088
26	Huntingtons disease_Homo sapiens_hsa05016	1.52807462
27	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.52123321
28	One carbon pool by folate_Homo sapiens_hsa00670	1.48103285
29	Caffeine metabolism_Homo sapiens_hsa00232	1.44877606
30	Propanoate metabolism_Homo sapiens_hsa00640	1.42756110
31	Nucleotide excision repair_Homo sapiens_hsa03420	1.37036478
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.25981595
33	Selenocompound metabolism_Homo sapiens_hsa00450	1.25582380
34	Fatty acid elongation_Homo sapiens_hsa00062	1.25308522
35	Spliceosome_Homo sapiens_hsa03040	1.23689430
36	Pyrimidine metabolism_Homo sapiens_hsa00240	1.20957379
37	Fatty acid metabolism_Homo sapiens_hsa01212	1.17365604
38	Olfactory transduction_Homo sapiens_hsa04740	1.17336488
39	Cell cycle_Homo sapiens_hsa04110	1.17270234
40	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.16828602
41	Regulation of autophagy_Homo sapiens_hsa04140	1.10855717
42	Tryptophan metabolism_Homo sapiens_hsa00380	1.10852347
43	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.10423572
44	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.09496138
45	Purine metabolism_Homo sapiens_hsa00230	1.09485151
46	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.08984749
47	Retinol metabolism_Homo sapiens_hsa00830	1.08406194
48	Peroxisome_Homo sapiens_hsa04146	1.06604841
49	Ether lipid metabolism_Homo sapiens_hsa00565	1.06057383
50	Chemical carcinogenesis_Homo sapiens_hsa05204	1.04926091
51	Fatty acid degradation_Homo sapiens_hsa00071	1.04886102
52	Oocyte meiosis_Homo sapiens_hsa04114	1.04004554
53	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.00865171
54	Nicotine addiction_Homo sapiens_hsa05033	1.00312424
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.99303441
56	Alzheimers disease_Homo sapiens_hsa05010	0.97110853
57	Cardiac muscle contraction_Homo sapiens_hsa04260	0.94872425
58	Taste transduction_Homo sapiens_hsa04742	0.92553997
59	Sulfur metabolism_Homo sapiens_hsa00920	0.92531760
60	Glutathione metabolism_Homo sapiens_hsa00480	0.89267930
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.83033854
62	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.78794409
63	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.78659238
64	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.76649552
65	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.75461797
66	Ribosome_Homo sapiens_hsa03010	0.74636742
67	beta-Alanine metabolism_Homo sapiens_hsa00410	0.74274440
68	Metabolic pathways_Homo sapiens_hsa01100	0.74029031
69	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.69575432
70	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.68017582
71	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.64802396
72	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.62278936
73	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.61954089
74	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.59542344
75	p53 signaling pathway_Homo sapiens_hsa04115	0.58494722
76	Glycerolipid metabolism_Homo sapiens_hsa00561	0.56156516
77	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.55729954
78	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.55584736
79	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.53283683
80	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.52958688
81	mRNA surveillance pathway_Homo sapiens_hsa03015	0.52800801
82	Steroid biosynthesis_Homo sapiens_hsa00100	0.49892288
83	Folate biosynthesis_Homo sapiens_hsa00790	0.47420007
84	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.47379448
85	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.46771128
86	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.46090043
87	Fat digestion and absorption_Homo sapiens_hsa04975	0.45156636
88	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.42237510
89	Salivary secretion_Homo sapiens_hsa04970	0.40401229
90	Circadian rhythm_Homo sapiens_hsa04710	0.39652713
91	Primary immunodeficiency_Homo sapiens_hsa05340	0.39102505
92	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.38119726
93	Pancreatic secretion_Homo sapiens_hsa04972	0.38027445
94	Lysine degradation_Homo sapiens_hsa00310	0.36600246
95	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.36275612
96	Pyruvate metabolism_Homo sapiens_hsa00620	0.35828225
97	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.35517798
98	Serotonergic synapse_Homo sapiens_hsa04726	0.33551192
99	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.32411235
100	Morphine addiction_Homo sapiens_hsa05032	0.30681548

ZNF98

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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