ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.96847991
2	fucose catabolic process (GO:0019317)	4.61712037
3	L-fucose metabolic process (GO:0042354)	4.61712037
4	L-fucose catabolic process (GO:0042355)	4.61712037
5	piRNA metabolic process (GO:0034587)	4.33964384
6	response to pheromone (GO:0019236)	4.28841139
7	DNA deamination (GO:0045006)	4.11300749
8	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.73539897
9	kynurenine metabolic process (GO:0070189)	3.71506120
10	tryptophan catabolic process (GO:0006569)	3.70831489
11	indole-containing compound catabolic process (GO:0042436)	3.70831489
12	indolalkylamine catabolic process (GO:0046218)	3.70831489
13	indolalkylamine metabolic process (GO:0006586)	3.68525108
14	water-soluble vitamin biosynthetic process (GO:0042364)	3.50914355
15	platelet dense granule organization (GO:0060155)	3.37310012
16	DNA methylation involved in gamete generation (GO:0043046)	3.33215082
17	synapsis (GO:0007129)	3.30894286
18	cellular ketone body metabolic process (GO:0046950)	3.30706240
19	tryptophan metabolic process (GO:0006568)	3.30653726
20	negative regulation of telomere maintenance (GO:0032205)	3.29070687
21	regulation of meiosis I (GO:0060631)	3.27247430
22	DNA double-strand break processing (GO:0000729)	3.24010799
23	neural tube formation (GO:0001841)	3.23292745
24	detection of light stimulus involved in sensory perception (GO:0050962)	3.20380416
25	detection of light stimulus involved in visual perception (GO:0050908)	3.20380416
26	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.17596990
27	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.17518016
28	respiratory chain complex IV assembly (GO:0008535)	3.17470332
29	epithelial cilium movement (GO:0003351)	3.15630446
30	kidney morphogenesis (GO:0060993)	3.14318266
31	protein-cofactor linkage (GO:0018065)	3.07216065
32	preassembly of GPI anchor in ER membrane (GO:0016254)	3.03316900
33	gamma-aminobutyric acid transport (GO:0015812)	3.00964166
34	ketone body metabolic process (GO:1902224)	2.98662286
35	regulation of glucokinase activity (GO:0033131)	2.91094768
36	regulation of hexokinase activity (GO:1903299)	2.91094768
37	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.89328832
38	sulfation (GO:0051923)	2.89230632
39	protein complex biogenesis (GO:0070271)	2.88778521
40	replication fork processing (GO:0031297)	2.88579259
41	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.87846963
42	male meiosis I (GO:0007141)	2.87159129
43	recombinational repair (GO:0000725)	2.84070680
44	axoneme assembly (GO:0035082)	2.83492680
45	double-strand break repair via homologous recombination (GO:0000724)	2.82618024
46	cytochrome complex assembly (GO:0017004)	2.82566893
47	indole-containing compound metabolic process (GO:0042430)	2.81775021
48	protein polyglutamylation (GO:0018095)	2.81644167
49	photoreceptor cell maintenance (GO:0045494)	2.79507663
50	male meiosis (GO:0007140)	2.79160001
51	NADH dehydrogenase complex assembly (GO:0010257)	2.78992474
52	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.78992474
53	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.78992474
54	reciprocal DNA recombination (GO:0035825)	2.75918099
55	reciprocal meiotic recombination (GO:0007131)	2.75918099
56	nonmotile primary cilium assembly (GO:0035058)	2.74370918
57	positive regulation of meiosis (GO:0045836)	2.72639917
58	regulation of cilium movement (GO:0003352)	2.71981061
59	negative regulation of mast cell activation (GO:0033004)	2.70355760
60	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.69881657
61	neuronal action potential (GO:0019228)	2.69323898
62	regulation of action potential (GO:0098900)	2.68690533
63	mitochondrial respiratory chain complex assembly (GO:0033108)	2.67660652
64	cornea development in camera-type eye (GO:0061303)	2.65763169
65	mannosylation (GO:0097502)	2.65630898
66	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.63200182
67	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.61787781
68	cilium morphogenesis (GO:0060271)	2.61151442
69	cellular response to ATP (GO:0071318)	2.60489314
70	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.59440047
71	protein neddylation (GO:0045116)	2.58997521
72	retinal cone cell development (GO:0046549)	2.58848078
73	ubiquinone biosynthetic process (GO:0006744)	2.58767056
74	protein K11-linked deubiquitination (GO:0035871)	2.57347700
75	protein localization to cilium (GO:0061512)	2.56219713
76	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.53918972
77	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.53918972
78	reflex (GO:0060004)	2.53417060
79	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.53415344
80	positive regulation of meiotic cell cycle (GO:0051446)	2.52965124
81	photoreceptor cell development (GO:0042461)	2.51988759
82	ubiquinone metabolic process (GO:0006743)	2.51848856
83	centriole replication (GO:0007099)	2.50208797
84	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.49961774
85	cilium organization (GO:0044782)	2.49285308
86	somite rostral/caudal axis specification (GO:0032525)	2.49095872
87	rhodopsin mediated signaling pathway (GO:0016056)	2.48954290
88	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.47706543
89	behavioral response to ethanol (GO:0048149)	2.47447569
90	amine catabolic process (GO:0009310)	2.47373706
91	cellular biogenic amine catabolic process (GO:0042402)	2.47373706
92	regulation of mesoderm development (GO:2000380)	2.46980790
93	adenosine metabolic process (GO:0046085)	2.46851360
94	adaptation of signaling pathway (GO:0023058)	2.45456058
95	multicellular organism reproduction (GO:0032504)	2.45164020
96	auditory receptor cell stereocilium organization (GO:0060088)	2.44254364
97	rRNA catabolic process (GO:0016075)	2.44013997
98	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.43606580
99	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.43606580
100	cilium movement (GO:0003341)	2.41353233

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	* ZNF274_21170338_ChIP-Seq_K562_Hela	3.88798344
2	VDR_22108803_ChIP-Seq_LS180_Human	3.54463348
3	IGF1R_20145208_ChIP-Seq_DFB_Human	2.86810237
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.85977548
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.58297044
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.56300020
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.49013268
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.47980099
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.43669014
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.34440694
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.27106545
12	EWS_26573619_Chip-Seq_HEK293_Human	2.16526717
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.12476927
14	P300_19829295_ChIP-Seq_ESCs_Human	2.11539727
15	FUS_26573619_Chip-Seq_HEK293_Human	2.11447998
16	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.03242887
17	* CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.98796385
18	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.98388135
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.98092242
20	* TAF15_26573619_Chip-Seq_HEK293_Human	1.94237847
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.85775424
22	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.85657656
23	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.81507882
24	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.74589163
25	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.73346733
26	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.69939778
27	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.69786036
28	BCAT_22108803_ChIP-Seq_LS180_Human	1.64655466
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.61264973
30	IRF1_19129219_ChIP-ChIP_H3396_Human	1.60155254
31	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.57968218
32	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.55353995
33	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.54457763
34	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.53412834
35	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.47309931
36	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.45320291
37	MYC_18940864_ChIP-ChIP_HL60_Human	1.45067252
38	CBP_20019798_ChIP-Seq_JUKART_Human	1.44544241
39	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.44544241
40	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.43606312
41	AR_25329375_ChIP-Seq_VCAP_Human	1.42444685
42	STAT3_23295773_ChIP-Seq_U87_Human	1.42417543
43	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.41693710
44	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.40150571
45	SMAD4_21799915_ChIP-Seq_A2780_Human	1.39374643
46	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.39343130
47	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.37467551
48	TCF4_23295773_ChIP-Seq_U87_Human	1.37134181
49	SOX2_19829295_ChIP-Seq_ESCs_Human	1.37055948
50	NANOG_19829295_ChIP-Seq_ESCs_Human	1.37055948
51	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.37041353
52	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.37041353
53	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.35261231
54	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.34524751
55	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.33280183
56	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.33134398
57	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.32056156
58	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.31116556
59	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.30885931
60	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.30657495
61	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.30419299
62	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.30419299
63	TCF4_22108803_ChIP-Seq_LS180_Human	1.29394356
64	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.27690577
65	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.26097413
66	ELK1_19687146_ChIP-ChIP_HELA_Human	1.25991793
67	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.25080431
68	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.22718977
69	REST_21632747_ChIP-Seq_MESCs_Mouse	1.22245931
70	RNF2_27304074_Chip-Seq_NSC_Mouse	1.20784061
71	RUNX2_22187159_ChIP-Seq_PCA_Human	1.20783111
72	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.18940694
73	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.17859450
74	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.17541720
75	NCOR_22424771_ChIP-Seq_293T_Human	1.16876069
76	AR_20517297_ChIP-Seq_VCAP_Human	1.15747430
77	VDR_23849224_ChIP-Seq_CD4+_Human	1.14666315
78	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.14629498
79	HOXB7_26014856_ChIP-Seq_BT474_Human	1.14453193
80	* ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.12435786
81	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.12270766
82	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.11392239
83	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.11139248
84	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.10861439
85	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.09289315
86	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.09178194
87	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.08981620
88	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.07487296
89	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.07455244
90	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.07092446
91	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.05902431
92	P53_22387025_ChIP-Seq_ESCs_Mouse	1.05338016
93	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.02718508
94	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.02373219
95	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.01347033
96	CDX2_22108803_ChIP-Seq_LS180_Human	1.00749182
97	AR_21572438_ChIP-Seq_LNCaP_Human	0.95407119
98	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.95152236
99	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95135184
100	P300_18555785_Chip-Seq_ESCs_Mouse	0.93806049

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.39763482
2	MP0002102_abnormal_ear_morphology	2.69735611
3	MP0000569_abnormal_digit_pigmentation	2.68481994
4	MP0003195_calcinosis	2.63421036
5	MP0002837_dystrophic_cardiac_calcinosis	2.52293866
6	MP0005551_abnormal_eye_electrophysiolog	2.47301012
7	MP0001968_abnormal_touch/_nociception	2.25893675
8	MP0006072_abnormal_retinal_apoptosis	2.18803922
9	MP0006292_abnormal_olfactory_placode	2.06864042
10	MP0004885_abnormal_endolymph	2.01124250
11	MP0005646_abnormal_pituitary_gland	1.99447396
12	MP0002876_abnormal_thyroid_physiology	1.95103456
13	MP0001986_abnormal_taste_sensitivity	1.94966992
14	MP0003136_yellow_coat_color	1.94939915
15	MP0002736_abnormal_nociception_after	1.93389874
16	MP0003880_abnormal_central_pattern	1.92707616
17	MP0005645_abnormal_hypothalamus_physiol	1.91745799
18	MP0003787_abnormal_imprinting	1.89803388
19	MP0009745_abnormal_behavioral_response	1.87139215
20	MP0008875_abnormal_xenobiotic_pharmacok	1.80178620
21	MP0008872_abnormal_physiological_respon	1.78617708
22	MP0005253_abnormal_eye_physiology	1.76826309
23	MP0003646_muscle_fatigue	1.71142500
24	MP0004142_abnormal_muscle_tone	1.68870852
25	MP0009046_muscle_twitch	1.68757295
26	MP0002938_white_spotting	1.67683864
27	MP0001501_abnormal_sleep_pattern	1.63438552
28	MP0002272_abnormal_nervous_system	1.60146809
29	MP0004043_abnormal_pH_regulation	1.58881830
30	MP0000427_abnormal_hair_cycle	1.58478991
31	MP0004133_heterotaxia	1.57014635
32	MP0004147_increased_porphyrin_level	1.53816485
33	MP0002653_abnormal_ependyma_morphology	1.53510549
34	MP0008058_abnormal_DNA_repair	1.52895937
35	MP0002638_abnormal_pupillary_reflex	1.50602027
36	MP0000631_abnormal_neuroendocrine_gland	1.48312979
37	MP0005174_abnormal_tail_pigmentation	1.47935518
38	MP0006276_abnormal_autonomic_nervous	1.47428532
39	MP0005389_reproductive_system_phenotype	1.45601850
40	MP0001485_abnormal_pinna_reflex	1.42657790
41	MP0001486_abnormal_startle_reflex	1.42497618
42	MP0000372_irregular_coat_pigmentation	1.42439716
43	MP0002160_abnormal_reproductive_system	1.38493098
44	MP0001529_abnormal_vocalization	1.36493062
45	MP0003011_delayed_dark_adaptation	1.34234124
46	MP0010386_abnormal_urinary_bladder	1.33418577
47	MP0003718_maternal_effect	1.33170868
48	MP0002735_abnormal_chemical_nociception	1.29100141
49	MP0002234_abnormal_pharynx_morphology	1.26594859
50	MP0005084_abnormal_gallbladder_morpholo	1.25800137
51	MP0001984_abnormal_olfaction	1.24942350
52	MP0002733_abnormal_thermal_nociception	1.23630700
53	MP0005379_endocrine/exocrine_gland_phen	1.20541681
54	MP0002572_abnormal_emotion/affect_behav	1.19916394
55	MP0002064_seizures	1.19364202
56	MP0004145_abnormal_muscle_electrophysio	1.18876279
57	MP0001970_abnormal_pain_threshold	1.17414114
58	MP0002163_abnormal_gland_morphology	1.17054089
59	MP0002277_abnormal_respiratory_mucosa	1.16650354
60	MP0001919_abnormal_reproductive_system	1.15921321
61	MP0002254_reproductive_system_inflammat	1.10472941
62	MP0000383_abnormal_hair_follicle	1.07961749
63	MP0005075_abnormal_melanosome_morpholog	1.07452093
64	MP0008995_early_reproductive_senescence	1.07315697
65	MP0002557_abnormal_social/conspecific_i	1.06792872
66	MP0005386_behavior/neurological_phenoty	1.05068713
67	MP0004924_abnormal_behavior	1.05068713
68	MP0004215_abnormal_myocardial_fiber	1.02121940
69	MP0004742_abnormal_vestibular_system	1.01614285
70	MP0002095_abnormal_skin_pigmentation	1.01044408
71	MP0005195_abnormal_posterior_eye	1.00567721
72	MP0001929_abnormal_gametogenesis	0.99782144
73	MP0002210_abnormal_sex_determination	0.97729312
74	MP0003252_abnormal_bile_duct	0.95880300
75	MP0002751_abnormal_autonomic_nervous	0.95722988
76	MP0005410_abnormal_fertilization	0.95653979
77	MP0002138_abnormal_hepatobiliary_system	0.95247516
78	MP0002928_abnormal_bile_duct	0.94481861
79	MP0003698_abnormal_male_reproductive	0.94390413
80	MP0002067_abnormal_sensory_capabilities	0.94150847
81	MP0000647_abnormal_sebaceous_gland	0.93789574
82	MP0002734_abnormal_mechanical_nocicepti	0.91909300
83	MP0003635_abnormal_synaptic_transmissio	0.89089631
84	MP0003890_abnormal_embryonic-extraembry	0.87526075
85	MP0000653_abnormal_sex_gland	0.86580416
86	MP0005085_abnormal_gallbladder_physiolo	0.86385969
87	MP0001963_abnormal_hearing_physiology	0.86075457
88	MP0002063_abnormal_learning/memory/cond	0.85808331
89	MP0001905_abnormal_dopamine_level	0.84120122
90	MP0000026_abnormal_inner_ear	0.83671196
91	MP0003121_genomic_imprinting	0.83588137
92	MP0002752_abnormal_somatic_nervous	0.82001882
93	MP0008775_abnormal_heart_ventricle	0.80323311
94	MP0001145_abnormal_male_reproductive	0.78994738
95	MP0005332_abnormal_amino_acid	0.77438416
96	MP0001324_abnormal_eye_pigmentation	0.77299225
97	MP0002909_abnormal_adrenal_gland	0.77265184
98	MP0003567_abnormal_fetal_cardiomyocyte	0.77048355
99	MP0003137_abnormal_impulse_conducting	0.77044953
100	MP0000230_abnormal_systemic_arterial	0.75544359

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.30799742
2	Abnormality of midbrain morphology (HP:0002418)	3.98335342
3	Molar tooth sign on MRI (HP:0002419)	3.98335342
4	Pancreatic fibrosis (HP:0100732)	3.94462249
5	Congenital stationary night blindness (HP:0007642)	3.81000308
6	True hermaphroditism (HP:0010459)	3.80858198
7	Nephronophthisis (HP:0000090)	3.77983194
8	Abnormality of the renal medulla (HP:0100957)	3.24448180
9	Abnormality of the renal cortex (HP:0011035)	3.22866700
10	Medial flaring of the eyebrow (HP:0010747)	2.95118517
11	Type II lissencephaly (HP:0007260)	2.90209884
12	Abolished electroretinogram (ERG) (HP:0000550)	2.88939726
13	Attenuation of retinal blood vessels (HP:0007843)	2.77503121
14	Pendular nystagmus (HP:0012043)	2.72903797
15	Hyperventilation (HP:0002883)	2.70132184
16	Chronic hepatic failure (HP:0100626)	2.64269368
17	Gaze-evoked nystagmus (HP:0000640)	2.61892272
18	Renal cortical cysts (HP:0000803)	2.60577990
19	Cystic liver disease (HP:0006706)	2.54518575
20	Large for gestational age (HP:0001520)	2.53578580
21	Tubular atrophy (HP:0000092)	2.51854794
22	Abnormal rod and cone electroretinograms (HP:0008323)	2.50905669
23	Sclerocornea (HP:0000647)	2.41114340
24	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.40181182
25	Abnormality of alanine metabolism (HP:0010916)	2.40181182
26	Hyperalaninemia (HP:0003348)	2.40181182
27	Inability to walk (HP:0002540)	2.37702876
28	Abnormal drinking behavior (HP:0030082)	2.36714903
29	Polydipsia (HP:0001959)	2.36714903
30	Increased corneal curvature (HP:0100692)	2.36043973
31	Keratoconus (HP:0000563)	2.36043973
32	Acute necrotizing encephalopathy (HP:0006965)	2.27989280
33	Methylmalonic acidemia (HP:0002912)	2.27057526
34	Progressive inability to walk (HP:0002505)	2.26959331
35	Increased CSF lactate (HP:0002490)	2.26823848
36	Furrowed tongue (HP:0000221)	2.23063825
37	Mitochondrial inheritance (HP:0001427)	2.20319471
38	Decreased central vision (HP:0007663)	2.19252948
39	Gait imbalance (HP:0002141)	2.18892839
40	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.16336871
41	Cerebellar dysplasia (HP:0007033)	2.14523418
42	Progressive macrocephaly (HP:0004481)	2.12899513
43	Congenital primary aphakia (HP:0007707)	2.12424000
44	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.11742006
45	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.11245298
46	Acute encephalopathy (HP:0006846)	2.09282053
47	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.08695217
48	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.08354054
49	Lissencephaly (HP:0001339)	2.07815492
50	Hyperglycinuria (HP:0003108)	2.06593707
51	Intestinal atresia (HP:0011100)	2.06252754
52	Absent/shortened dynein arms (HP:0200106)	2.05529276
53	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.05529276
54	Abnormality of the labia minora (HP:0012880)	2.04759873
55	Congenital, generalized hypertrichosis (HP:0004540)	2.04293742
56	Anencephaly (HP:0002323)	2.03378028
57	Hypothermia (HP:0002045)	2.02938323
58	Bile duct proliferation (HP:0001408)	2.02504870
59	Abnormal biliary tract physiology (HP:0012439)	2.02504870
60	Methylmalonic aciduria (HP:0012120)	2.02327858
61	Male pseudohermaphroditism (HP:0000037)	2.01369475
62	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.00823294
63	Hypoplasia of the fovea (HP:0007750)	2.00823294
64	Hepatocellular necrosis (HP:0001404)	2.00700607
65	Nephrogenic diabetes insipidus (HP:0009806)	1.99222797
66	Abnormality of the pons (HP:0007361)	1.98293388
67	Hepatic necrosis (HP:0002605)	1.97313241
68	Polyuria (HP:0000103)	1.96764888
69	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.96646613
70	Congenital hepatic fibrosis (HP:0002612)	1.96551946
71	Optic disc pallor (HP:0000543)	1.92825292
72	Broad-based gait (HP:0002136)	1.92136164
73	Focal motor seizures (HP:0011153)	1.90028094
74	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.89043260
75	Progressive cerebellar ataxia (HP:0002073)	1.88781482
76	Hypoplasia of the pons (HP:0012110)	1.88232619
77	Hemiparesis (HP:0001269)	1.88082330
78	Genital tract atresia (HP:0001827)	1.87462929
79	Hypomagnesemia (HP:0002917)	1.86674587
80	Ketosis (HP:0001946)	1.86628942
81	Optic nerve hypoplasia (HP:0000609)	1.86270479
82	Postaxial foot polydactyly (HP:0001830)	1.83776101
83	Bony spicule pigmentary retinopathy (HP:0007737)	1.83662992
84	Abnormality of the ileum (HP:0001549)	1.83620066
85	Abnormality of macular pigmentation (HP:0008002)	1.82509042
86	Abnormal respiratory motile cilium morphology (HP:0005938)	1.82481503
87	Abnormal respiratory epithelium morphology (HP:0012253)	1.82481503
88	Chorioretinal atrophy (HP:0000533)	1.81586348
89	Ketoacidosis (HP:0001993)	1.80762035
90	Pachygyria (HP:0001302)	1.80590185
91	Stomach cancer (HP:0012126)	1.80570151
92	Abnormal mitochondria in muscle tissue (HP:0008316)	1.80224096
93	Decreased circulating renin level (HP:0003351)	1.80097349
94	Vaginal atresia (HP:0000148)	1.78594984
95	Lipid accumulation in hepatocytes (HP:0006561)	1.78389629
96	Bilateral microphthalmos (HP:0007633)	1.77370748
97	Asplenia (HP:0001746)	1.76517819
98	Meckel diverticulum (HP:0002245)	1.76236303
99	Absent speech (HP:0001344)	1.75808502
100	Abnormality of the fovea (HP:0000493)	1.74988109

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.28143304
2	BMPR1B	3.06600970
3	ADRBK2	3.01455848
4	MAP4K2	2.88386631
5	ZAK	2.86989056
6	WNK3	2.73784599
7	GRK1	2.48154445
8	ACVR1B	2.27404882
9	WNK4	2.22239560
10	PINK1	2.22008893
11	NUAK1	2.09704938
12	TAOK3	1.93587009
13	TLK1	1.88484325
14	INSRR	1.72643951
15	EIF2AK3	1.64926260
16	MAPK13	1.62617337
17	BCKDK	1.61164976
18	OXSR1	1.59805249
19	CASK	1.58401407
20	STK39	1.55051911
21	TRIM28	1.51422540
22	PNCK	1.47979912
23	MAP3K4	1.44415417
24	TXK	1.30626800
25	CAMKK2	1.27928034
26	MST4	1.27858591
27	STK38L	1.25110553
28	VRK2	1.25029732
29	MKNK2	1.19915137
30	VRK1	1.14213562
31	TGFBR1	1.12580693
32	TNIK	1.12483580
33	DAPK2	1.09709023
34	PLK2	1.06051148
35	PAK3	1.03452212
36	ADRBK1	0.96716288
37	PRKCE	0.94226069
38	PHKG1	0.90480204
39	PHKG2	0.90480204
40	DYRK2	0.89965119
41	PRKCG	0.88697104
42	BRSK2	0.87696928
43	CSNK1G2	0.87579819
44	PLK3	0.84420065
45	CSNK1G1	0.83521923
46	BCR	0.82813595
47	PLK4	0.80085490
48	MARK1	0.77765947
49	EPHA4	0.76486018
50	FGFR2	0.75623632
51	CSNK1G3	0.75297711
52	STK16	0.75136308
53	MAPKAPK3	0.74806087
54	TAF1	0.74321967
55	MAP2K7	0.73800623
56	NTRK3	0.69184483
57	WEE1	0.68452134
58	TIE1	0.67851375
59	CDK19	0.67364338
60	ERBB3	0.66396973
61	CSNK1A1L	0.65335481
62	TSSK6	0.63088357
63	IKBKB	0.62047111
64	STK3	0.60135299
65	PTK2B	0.58898219
66	KIT	0.58624468
67	TEC	0.58309197
68	PRKCI	0.55711132
69	EIF2AK2	0.55565215
70	FLT3	0.54345820
71	NME1	0.53706225
72	MKNK1	0.52817015
73	NTRK2	0.51842084
74	CAMK2A	0.51768655
75	PRKCQ	0.51257634
76	MAP2K6	0.50505276
77	MUSK	0.44079093
78	PKN1	0.43957813
79	RPS6KA5	0.43288451
80	GRK5	0.43280365
81	PRKACA	0.42959213
82	TNK2	0.42841286
83	CSNK1A1	0.42240035
84	PASK	0.41957983
85	MAPKAPK5	0.41845931
86	CHUK	0.41303880
87	PLK1	0.40861758
88	CAMK1	0.39855134
89	CDK8	0.38174257
90	GRK7	0.37897465
91	ATR	0.37676453
92	STK11	0.37655497
93	CSNK1D	0.35546077
94	NLK	0.35176005
95	IRAK1	0.34872748
96	ATM	0.33158243
97	CDK3	0.32897831
98	PRKG1	0.32836353
99	MAPK15	0.32335886
100	PRKCA	0.32154904

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.77349709
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.41250740
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.31850727
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.26975558
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.24051339
6	Protein export_Homo sapiens_hsa03060	2.20799537
7	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.20363971
8	Butanoate metabolism_Homo sapiens_hsa00650	2.12920087
9	Homologous recombination_Homo sapiens_hsa03440	2.12336088
10	Nitrogen metabolism_Homo sapiens_hsa00910	2.11807935
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.11520789
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.07614415
13	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.02972790
14	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.02640191
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.97430797
16	Basal transcription factors_Homo sapiens_hsa03022	1.97424056
17	Selenocompound metabolism_Homo sapiens_hsa00450	1.96195027
18	Caffeine metabolism_Homo sapiens_hsa00232	1.90217618
19	Parkinsons disease_Homo sapiens_hsa05012	1.82386927
20	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.81873651
21	Nicotine addiction_Homo sapiens_hsa05033	1.80775842
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.80624549
23	Tryptophan metabolism_Homo sapiens_hsa00380	1.74556175
24	Ether lipid metabolism_Homo sapiens_hsa00565	1.73716663
25	Propanoate metabolism_Homo sapiens_hsa00640	1.68627824
26	RNA polymerase_Homo sapiens_hsa03020	1.68365574
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.53743721
28	RNA degradation_Homo sapiens_hsa03018	1.42553380
29	One carbon pool by folate_Homo sapiens_hsa00670	1.36454028
30	Regulation of autophagy_Homo sapiens_hsa04140	1.31829174
31	Olfactory transduction_Homo sapiens_hsa04740	1.31347817
32	Taste transduction_Homo sapiens_hsa04742	1.31223005
33	Non-homologous end-joining_Homo sapiens_hsa03450	1.26210031
34	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.23009927
35	Huntingtons disease_Homo sapiens_hsa05016	1.18828548
36	Morphine addiction_Homo sapiens_hsa05032	1.16374589
37	Cardiac muscle contraction_Homo sapiens_hsa04260	1.15544098
38	Peroxisome_Homo sapiens_hsa04146	1.14986517
39	Alzheimers disease_Homo sapiens_hsa05010	1.14571659
40	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.11232204
41	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.06922495
42	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.05444194
43	Proteasome_Homo sapiens_hsa03050	1.00307677
44	Chemical carcinogenesis_Homo sapiens_hsa05204	0.99602049
45	Insulin secretion_Homo sapiens_hsa04911	0.99571127
46	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.99437552
47	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.99135213
48	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.98321619
49	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.98112822
50	Retinol metabolism_Homo sapiens_hsa00830	0.93732581
51	Sulfur metabolism_Homo sapiens_hsa00920	0.93409514
52	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.90961984
53	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.90537679
54	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.90152715
55	Collecting duct acid secretion_Homo sapiens_hsa04966	0.88248459
56	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.85893409
57	Serotonergic synapse_Homo sapiens_hsa04726	0.84324872
58	GABAergic synapse_Homo sapiens_hsa04727	0.84241738
59	Purine metabolism_Homo sapiens_hsa00230	0.81606494
60	Circadian entrainment_Homo sapiens_hsa04713	0.81371118
61	ABC transporters_Homo sapiens_hsa02010	0.80038471
62	beta-Alanine metabolism_Homo sapiens_hsa00410	0.79259023
63	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.71909361
64	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.71026138
65	Glutamatergic synapse_Homo sapiens_hsa04724	0.70784123
66	Salivary secretion_Homo sapiens_hsa04970	0.68368723
67	Primary immunodeficiency_Homo sapiens_hsa05340	0.68215788
68	Fat digestion and absorption_Homo sapiens_hsa04975	0.67591827
69	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.67432753
70	Metabolic pathways_Homo sapiens_hsa01100	0.66604692
71	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.64344054
72	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.62766532
73	Nucleotide excision repair_Homo sapiens_hsa03420	0.60909373
74	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.60773058
75	Asthma_Homo sapiens_hsa05310	0.60545773
76	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.60209464
77	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.59472595
78	Pyrimidine metabolism_Homo sapiens_hsa00240	0.59235978
79	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.58990566
80	Sulfur relay system_Homo sapiens_hsa04122	0.57322934
81	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.55455041
82	Mineral absorption_Homo sapiens_hsa04978	0.53744775
83	Fatty acid degradation_Homo sapiens_hsa00071	0.53685314
84	Calcium signaling pathway_Homo sapiens_hsa04020	0.52814253
85	Folate biosynthesis_Homo sapiens_hsa00790	0.52676624
86	Circadian rhythm_Homo sapiens_hsa04710	0.51527585
87	Histidine metabolism_Homo sapiens_hsa00340	0.50743010
88	Type I diabetes mellitus_Homo sapiens_hsa04940	0.50617658
89	Glycerolipid metabolism_Homo sapiens_hsa00561	0.49856931
90	Mismatch repair_Homo sapiens_hsa03430	0.49466581
91	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.48356660
92	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.46362875
93	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.46031874
94	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.45142642
95	Steroid biosynthesis_Homo sapiens_hsa00100	0.41897991
96	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.39706158
97	RNA transport_Homo sapiens_hsa03013	0.36968950
98	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.35191994
99	Fatty acid elongation_Homo sapiens_hsa00062	0.33582885
100	Dopaminergic synapse_Homo sapiens_hsa04728	0.32884796

ZNF99

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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