ZNFX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by symbiont of host defense response (GO:0052031)5.53633978
2modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.53633978
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.53633978
4positive regulation by organism of defense response of other organism involved in symbiotic interact5.53633978
5modulation by symbiont of host immune response (GO:0052553)5.53633978
6positive regulation by symbiont of host defense response (GO:0052509)5.53633978
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.06579561
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.06579561
9positive regulation of interferon-alpha production (GO:0032727)5.01906989
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.88607810
11regulation of interferon-alpha production (GO:0032647)4.75916232
12antigen processing and presentation of endogenous antigen (GO:0019883)4.71504827
13regulation of interferon-beta biosynthetic process (GO:0045357)4.47103041
14response to type I interferon (GO:0034340)4.37765077
15cellular response to type I interferon (GO:0071357)4.36274738
16type I interferon signaling pathway (GO:0060337)4.36274738
17negative regulation of interleukin-12 production (GO:0032695)4.23736420
18macrophage activation involved in immune response (GO:0002281)4.16974425
19negative regulation of cell killing (GO:0031342)4.10077468
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.10077468
21response to host immune response (GO:0052572)3.86357697
22response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.86357697
23response to interferon-alpha (GO:0035455)3.74014931
24response to peptidoglycan (GO:0032494)3.70255460
25regulation of cholesterol storage (GO:0010885)3.62527042
26cellular response to interferon-alpha (GO:0035457)3.59366808
27regulation of vitamin D biosynthetic process (GO:0060556)3.53085631
28response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.52112820
29response to host (GO:0075136)3.52112820
30response to host defenses (GO:0052200)3.52112820
31immunoglobulin mediated immune response (GO:0016064)3.48252845
32low-density lipoprotein particle clearance (GO:0034383)3.45957116
33positive regulation of interferon-beta production (GO:0032728)3.42070823
34microglial cell activation (GO:0001774)3.38895438
35neutrophil activation involved in immune response (GO:0002283)3.35948631
36lipopolysaccharide-mediated signaling pathway (GO:0031663)3.34126051
37positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.33898791
38positive regulation of gamma-delta T cell activation (GO:0046645)3.31039615
39positive regulation of natural killer cell differentiation (GO:0032825)3.30913340
40positive regulation of antigen processing and presentation (GO:0002579)3.28712941
41interferon-gamma-mediated signaling pathway (GO:0060333)3.26513391
42detection of other organism (GO:0098543)3.26071741
43germinal center formation (GO:0002467)3.23276973
44positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.20623757
45response to muramyl dipeptide (GO:0032495)3.20122886
46positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.19090619
47natural killer cell mediated immunity (GO:0002228)3.18938656
48natural killer cell mediated cytotoxicity (GO:0042267)3.18938656
49T-helper 1 type immune response (GO:0042088)3.18126636
50JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.17696894
51positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.16917499
52regulation of dendritic cell antigen processing and presentation (GO:0002604)3.16299591
53positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.16144543
54negative regulation of T cell mediated immunity (GO:0002710)3.11671966
55positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.11553760
56T cell migration (GO:0072678)3.10973425
57cellular response to virus (GO:0098586)3.10738798
58positive regulation of type 2 immune response (GO:0002830)3.06374217
59response to protozoan (GO:0001562)3.06326720
60apoptotic cell clearance (GO:0043277)3.05534105
61negative regulation of viral genome replication (GO:0045071)3.04360186
62regulation of gamma-delta T cell differentiation (GO:0045586)3.03452098
63regulation of T cell tolerance induction (GO:0002664)3.03257164
64detection of bacterium (GO:0016045)3.00707496
65I-kappaB phosphorylation (GO:0007252)3.00249065
66regulation of interleukin-12 biosynthetic process (GO:0045075)2.99209742
67detection of external biotic stimulus (GO:0098581)2.98127647
68negative regulation of cytokine production involved in immune response (GO:0002719)2.92518824
69negative regulation of lipid storage (GO:0010888)2.90840919
70tolerance induction (GO:0002507)2.89088812
71macrophage activation (GO:0042116)2.88111887
72regulation of type I interferon-mediated signaling pathway (GO:0060338)2.87753036
73regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.87507165
74myeloid dendritic cell activation (GO:0001773)2.85779481
75positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.85368991
76leukocyte aggregation (GO:0070486)2.84184535
77cellular extravasation (GO:0045123)2.84148307
78regulation of chronic inflammatory response (GO:0002676)2.83472377
79respiratory burst (GO:0045730)2.82608249
80regulation of vitamin metabolic process (GO:0030656)2.80135398
81positive regulation of cellular amide metabolic process (GO:0034250)2.79680446
82regulation of type 2 immune response (GO:0002828)2.79607624
83hydrogen peroxide biosynthetic process (GO:0050665)2.77427938
84positive regulation of interleukin-12 production (GO:0032735)2.77119496
85regulation of tolerance induction (GO:0002643)2.76463504
86positive regulation of toll-like receptor signaling pathway (GO:0034123)2.75997622
87growth hormone receptor signaling pathway (GO:0060396)2.75796686
88regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.73397223
89regulation of T-helper 1 cell differentiation (GO:0045625)2.69251907
90regulation of antigen processing and presentation (GO:0002577)2.69221621
91regulation of necroptotic process (GO:0060544)2.67857688
92granulocyte activation (GO:0036230)2.67808452
93regulation of RIG-I signaling pathway (GO:0039535)2.67327251
94myeloid cell activation involved in immune response (GO:0002275)2.67276036
95regulation of response to interferon-gamma (GO:0060330)2.66550627
96response to interleukin-15 (GO:0070672)2.65732384
97regulation of regulatory T cell differentiation (GO:0045589)2.64980396
98interferon-gamma secretion (GO:0072643)2.64352470
99regulation of T-helper 2 cell differentiation (GO:0045628)2.64304986
100response to interferon-gamma (GO:0034341)2.63082475
101regulation of interferon-beta production (GO:0032648)2.61708343
102positive regulation of tolerance induction (GO:0002645)2.61110185
103myeloid dendritic cell differentiation (GO:0043011)2.61058344
104regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.60387626
105detection of biotic stimulus (GO:0009595)2.59615492
106cellular response to interferon-gamma (GO:0071346)2.59536696
107regulation of interferon-gamma biosynthetic process (GO:0045072)2.59399689
108negative regulation of lymphocyte mediated immunity (GO:0002707)2.57937777
109NIK/NF-kappaB signaling (GO:0038061)2.57809610
110positive regulation of defense response to virus by host (GO:0002230)2.57584246
111negative regulation of innate immune response (GO:0045824)2.57383840
112positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.57091590
113lymphocyte chemotaxis (GO:0048247)2.56845507
114negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.56264424
115detection of molecule of bacterial origin (GO:0032490)2.56033842
116positive regulation of chemokine biosynthetic process (GO:0045080)2.55642439
117cellular response to exogenous dsRNA (GO:0071360)2.53776017
118neutrophil activation (GO:0042119)2.51796889
119regulation of mononuclear cell migration (GO:0071675)2.50853552
120defense response to protozoan (GO:0042832)2.50844571
121cellular response to interferon-beta (GO:0035458)2.47503311
122regulation of B cell receptor signaling pathway (GO:0050855)2.45620464
123regulation of interleukin-12 production (GO:0032655)2.43809994
124positive regulation of macrophage cytokine production (GO:0060907)2.41992825
125regulation of toll-like receptor signaling pathway (GO:0034121)2.41832302
126defense response to virus (GO:0051607)2.40381009
127regulation of macrophage chemotaxis (GO:0010758)2.39795636
128negative regulation of interleukin-17 production (GO:0032700)2.38695686
129production of molecular mediator involved in inflammatory response (GO:0002532)2.38322964
130regulation of gamma-delta T cell activation (GO:0046643)2.37033872
131response to lipoprotein particle (GO:0055094)2.37013407
132positive regulation of lipid storage (GO:0010884)2.36849428
133regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.35739219
134positive regulation of p38MAPK cascade (GO:1900745)2.35722657
135positive regulation of humoral immune response (GO:0002922)2.35417051
136reactive oxygen species biosynthetic process (GO:1903409)2.33234225
137regulation of membrane protein ectodomain proteolysis (GO:0051043)2.32889919
138B cell mediated immunity (GO:0019724)2.32748604
139cellular response to growth hormone stimulus (GO:0071378)2.32497287
140positive regulation of T cell cytokine production (GO:0002726)2.31509095

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.13354757
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.09328249
3* IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.62067779
4IRF8_27001747_Chip-Seq_BMDM_Mouse3.51802292
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.07136092
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.02623052
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.02200895
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.85915087
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.83548462
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.81050691
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.71198534
12GATA1_22025678_ChIP-Seq_K562_Human2.67107737
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.54223312
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.47296559
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.43117291
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.12581837
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.12070831
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.03030981
19* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.99235692
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.96502439
21LXR_22158963_ChIP-Seq_LIVER_Mouse1.89023472
22RXR_22158963_ChIP-Seq_LIVER_Mouse1.86459412
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.76242927
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.74408538
25EGR1_19374776_ChIP-ChIP_THP-1_Human1.74115545
26PPARA_22158963_ChIP-Seq_LIVER_Mouse1.71743409
27STAT4_19710469_ChIP-ChIP_TH1__Mouse1.68925046
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.66071416
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.64435686
30GATA2_21666600_ChIP-Seq_HMVEC_Human1.60215011
31SPI1_23127762_ChIP-Seq_K562_Human1.58050467
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.57335308
33RUNX_20019798_ChIP-Seq_JUKART_Human1.50711446
34PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.50638909
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49222965
36MYC_22102868_ChIP-Seq_BL_Human1.45618366
37VDR_24787735_ChIP-Seq_THP-1_Human1.45567105
38TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39087323
39FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.36973201
40MAF_26560356_Chip-Seq_TH1_Human1.36463445
41* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.31670958
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.28318521
43MAF_26560356_Chip-Seq_TH2_Human1.27780907
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27339531
45BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26903693
46NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.26242466
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25221233
48NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.24297389
49PU_27001747_Chip-Seq_BMDM_Mouse1.23826709
50* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22498668
51CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.20231807
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20055106
53EGR1_23403033_ChIP-Seq_LIVER_Mouse1.19888299
54PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18726214
55VDR_24763502_ChIP-Seq_THP-1_Human1.17199498
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.17098386
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16323547
58GATA1_19941826_ChIP-Seq_K562_Human1.16286991
59SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16189205
60TP63_17297297_ChIP-ChIP_HaCaT_Human1.15401650
61* MYB_26560356_Chip-Seq_TH2_Human1.15315924
62TCF7_22412390_ChIP-Seq_EML_Mouse1.14124031
63FOXO3_23340844_ChIP-Seq_DLD1_Human1.14064859
64KDM2B_26808549_Chip-Seq_DND41_Human1.12389663
65E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11819647
66ELK3_25401928_ChIP-Seq_HUVEC_Human1.10198519
67CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09411453
68ESR2_21235772_ChIP-Seq_MCF-7_Human1.09140503
69PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07038922
70* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.06595653
71* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.06595653
72MYB_26560356_Chip-Seq_TH1_Human1.05954998
73GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05903104
74GATA3_27048872_Chip-Seq_THYMUS_Human1.05637160
75RUNX1_22412390_ChIP-Seq_EML_Mouse1.05158331
76TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04415958
77* GATA1_19941827_ChIP-Seq_MEL_Mouse1.03563502
78LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.03328474
79KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03130433
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03062886
81GATA2_19941826_ChIP-Seq_K562_Human1.01651588
82JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00333890
83CLOCK_20551151_ChIP-Seq_293T_Human1.00077201
84RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99673987
85BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99001759
86GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97454834
87SCL_19346495_ChIP-Seq_HPC-7_Human0.96946165
88LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96494230
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93738428
90GATA3_26560356_Chip-Seq_TH2_Human0.92904935
91* FOXA2_19822575_ChIP-Seq_HepG2_Human0.92521540
92SPI1_23547873_ChIP-Seq_NB4_Human0.92186521
93ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91758853
94UTX_26944678_Chip-Seq_JUKART_Human0.91590370
95EGR1_19032775_ChIP-ChIP_M12_Human0.91556320
96PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91324339
97CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89284381
98VDR_21846776_ChIP-Seq_THP-1_Human0.89195319
99NOTCH1_21737748_ChIP-Seq_TLL_Human0.88443497
100* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88213456
101* SOX2_20726797_ChIP-Seq_SW620_Human0.87921657
102SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87679251
103KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87378097
104RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.86879693
105PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86187450
106KDM2B_26808549_Chip-Seq_JURKAT_Human0.85446105
107GATA1_22383799_ChIP-Seq_G1ME_Mouse0.85377612
108LXR_22292898_ChIP-Seq_THP-1_Human0.84926064
109SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.84546796
110TRIM28_21343339_ChIP-Seq_HEK293_Human0.84366817
111KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.84343655
112CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83581723
113NRF2_20460467_ChIP-Seq_MEFs_Mouse0.82986139
114NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.82986139
115* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.82948670
116ESR1_21235772_ChIP-Seq_MCF-7_Human0.81921789
117RACK7_27058665_Chip-Seq_MCF-7_Human0.81154693
118TBX20_22080862_ChIP-Seq_HEART_Mouse0.80873405
119TBX20_22328084_ChIP-Seq_HEART_Mouse0.80873405
120RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.80468384
121TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80325426
122CJUN_26792858_Chip-Seq_BT549_Human0.79144357
123FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.78680724
124JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78465244

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.60851220
2MP0005058_abnormal_lysosome_morphology3.35083757
3MP0003303_peritoneal_inflammation3.20614703
4MP0004510_myositis3.01375300
5MP0009785_altered_susceptibility_to2.92688433
6MP0003436_decreased_susceptibility_to2.90339006
7MP0006082_CNS_inflammation2.79909760
8MP0003724_increased_susceptibility_to2.76382628
9MP0001790_abnormal_immune_system2.64792811
10MP0005387_immune_system_phenotype2.64792811
11MP0000685_abnormal_immune_system2.48329644
12MP0002419_abnormal_innate_immunity2.47783817
13MP0005000_abnormal_immune_tolerance2.40767036
14MP0003191_abnormal_cellular_cholesterol2.38563072
15MP0002148_abnormal_hypersensitivity_rea2.38559152
16MP0005025_abnormal_response_to2.34505271
17MP0009840_abnormal_foam_cell2.33695069
18MP0003300_gastrointestinal_ulcer2.29854560
19MP0005451_abnormal_body_composition2.22883059
20MP0003763_abnormal_thymus_physiology2.08172674
21MP0003172_abnormal_lysosome_physiology2.05329149
22MP0002452_abnormal_antigen_presenting2.01849306
23MP0004947_skin_inflammation2.00448958
24MP0001800_abnormal_humoral_immune1.99576005
25MP0002723_abnormal_immune_serum1.95118168
26MP0001533_abnormal_skeleton_physiology1.84403891
27MP0005671_abnormal_response_to1.82005944
28MP0009333_abnormal_splenocyte_physiolog1.78833153
29MP0003075_altered_response_to1.78778604
30MP0000604_amyloidosis1.78618953
31MP0005464_abnormal_platelet_physiology1.76057825
32MP0002166_altered_tumor_susceptibility1.73170872
33MP0005167_abnormal_blood-brain_barrier1.69855663
34MP0001819_abnormal_immune_cell1.66753726
35MP0002420_abnormal_adaptive_immunity1.62084267
36MP0008469_abnormal_protein_level1.62020102
37MP0000569_abnormal_digit_pigmentation1.61532364
38MP0002138_abnormal_hepatobiliary_system1.61135018
39MP0003690_abnormal_glial_cell1.59767494
40MP0001845_abnormal_inflammatory_respons1.56699790
41MP0009764_decreased_sensitivity_to1.56690758
42MP0003705_abnormal_hypodermis_morpholog1.54471548
43MP0009278_abnormal_bone_marrow1.53635903
44MP0002006_tumorigenesis1.52466218
45MP0003045_fibrosis1.51850391
46MP0005310_abnormal_salivary_gland1.51063963
47MP0005360_urolithiasis1.46036689
48MP0004858_abnormal_nervous_system1.41590162
49MP0008004_abnormal_stomach_pH1.39847720
50MP0000343_altered_response_to1.36578254
51MP0003448_altered_tumor_morphology1.35868459
52MP0010155_abnormal_intestine_physiology1.35280756
53MP0006054_spinal_hemorrhage1.34406021
54MP0002332_abnormal_exercise_endurance1.30582960
55MP0008260_abnormal_autophagy1.29720376
56MP0002139_abnormal_hepatobiliary_system1.27387559
57MP0002998_abnormal_bone_remodeling1.27309895
58MP0002405_respiratory_system_inflammati1.27221096
59MP0001853_heart_inflammation1.26447960
60MP0004130_abnormal_muscle_cell1.24619451
61MP0008438_abnormal_cutaneous_collagen1.23748968
62MP0003566_abnormal_cell_adhesion1.23235637
63MP0005076_abnormal_cell_differentiation1.20204834
64MP0005670_abnormal_white_adipose1.18837035
65MP0002254_reproductive_system_inflammat1.18772451
66MP0003091_abnormal_cell_migration1.17788214
67MP0003195_calcinosis1.16977222
68MP0002722_abnormal_immune_system1.15475614
69MP0000716_abnormal_immune_system1.15046090
70MP0005166_decreased_susceptibility_to1.11879574
71MP0003183_abnormal_peptide_metabolism1.08744612
72MP0005257_abnormal_intraocular_pressure1.07974000
73MP0000609_abnormal_liver_physiology1.05538568
74MP0010307_abnormal_tumor_latency1.05168144
75MP0005397_hematopoietic_system_phenotyp1.03872240
76MP0001545_abnormal_hematopoietic_system1.03872240
77MP0005083_abnormal_biliary_tract1.03699413
78MP0003252_abnormal_bile_duct1.03073461
79MP0004883_abnormal_blood_vessel1.03068497
80MP0009763_increased_sensitivity_to1.02981533
81MP0003866_abnormal_defecation1.02423466
82MP0002933_joint_inflammation1.01513109
83MP0010329_abnormal_lipoprotein_level1.01255150
84MP0002398_abnormal_bone_marrow1.01159989
85MP0004808_abnormal_hematopoietic_stem0.99707873
86MP0004185_abnormal_adipocyte_glucose0.97620796
87MP0005390_skeleton_phenotype0.92967987
88MP0005164_abnormal_response_to0.92219759
89MP0001958_emphysema0.90402047
90MP0000465_gastrointestinal_hemorrhage0.89321236
91MP0002429_abnormal_blood_cell0.86830502
92MP0010352_gastrointestinal_tract_polyps0.86056170
93MP0000703_abnormal_thymus_morphology0.86017587
94MP0000249_abnormal_blood_vessel0.85184697
95MP0001851_eye_inflammation0.85102647
96MP0000689_abnormal_spleen_morphology0.84787987
97MP0003453_abnormal_keratinocyte_physiol0.84772998
98MP0003279_aneurysm0.83628310
99MP0005319_abnormal_enzyme/_coenzyme0.81251007
100MP0010234_abnormal_vibrissa_follicle0.80508033
101MP0001348_abnormal_lacrimal_gland0.79802614
102MP0002118_abnormal_lipid_homeostasis0.79532835
103MP0002877_abnormal_melanocyte_morpholog0.79355848
104MP0002136_abnormal_kidney_physiology0.78888603
105MP0005165_increased_susceptibility_to0.78865047
106MP0004782_abnormal_surfactant_physiolog0.78482716
107MP0003828_pulmonary_edema0.78123774
108MP0001873_stomach_inflammation0.77334072
109MP0003656_abnormal_erythrocyte_physiolo0.76932650
110MP0005584_abnormal_enzyme/coenzyme_acti0.76677616
111MP0005023_abnormal_wound_healing0.76588751
112MP0000767_abnormal_smooth_muscle0.76578268
113MP0002168_other_aberrant_phenotype0.75518740
114MP0009643_abnormal_urine_homeostasis0.75240565
115MP0000371_diluted_coat_color0.75237819
116MP0005666_abnormal_adipose_tissue0.74696396
117MP0003795_abnormal_bone_structure0.74550761
118MP0000858_altered_metastatic_potential0.74133632
119MP0005365_abnormal_bile_salt0.73719517
120MP0009765_abnormal_xenobiotic_induced0.72453333
121MP0004381_abnormal_hair_follicle0.71955609
122MP0008875_abnormal_xenobiotic_pharmacok0.71037035
123MP0001663_abnormal_digestive_system0.70807332
124MP0002090_abnormal_vision0.70760178
125MP0008874_decreased_physiological_sensi0.69898372

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.03907527
2Recurrent abscess formation (HP:0002722)4.84827917
3Systemic lupus erythematosus (HP:0002725)4.69695833
4Autoimmune thrombocytopenia (HP:0001973)4.60739945
5Recurrent bacterial skin infections (HP:0005406)4.58161416
6Recurrent gram-negative bacterial infections (HP:0005420)4.57039805
7Increased cerebral lipofuscin (HP:0011813)3.82616314
8Abnormality of macrophages (HP:0004311)3.81796999
9Vacuolated lymphocytes (HP:0001922)3.50135678
10T lymphocytopenia (HP:0005403)3.42030128
11Mediastinal lymphadenopathy (HP:0100721)3.35584374
12Abnormality of T cell number (HP:0011839)3.33496515
13Myocardial infarction (HP:0001658)3.31696711
14Keratoconjunctivitis sicca (HP:0001097)3.30831135
15Abnormality of the nasal mucosa (HP:0000433)3.16013122
16Increased neuronal autofluorescent lipopigment (HP:0002074)3.15523940
17Elevated erythrocyte sedimentation rate (HP:0003565)3.13540705
18Nasal polyposis (HP:0100582)3.12304157
19Dysostosis multiplex (HP:0000943)3.11893335
20Gingivitis (HP:0000230)3.10575663
21Orchitis (HP:0100796)3.09563223
22Axonal loss (HP:0003447)3.09323247
23Chronic otitis media (HP:0000389)3.07359134
24Tetraparesis (HP:0002273)3.04018333
25Hematochezia (HP:0002573)3.02588320
26Keratoconjunctivitis (HP:0001096)3.01811611
27Complement deficiency (HP:0004431)3.01038443
28Loss of speech (HP:0002371)2.99538939
29Myositis (HP:0100614)2.96758161
30Recurrent skin infections (HP:0001581)2.95259925
31Recurrent fungal infections (HP:0002841)2.94963518
32Recurrent viral infections (HP:0004429)2.87214227
33Glomerulonephritis (HP:0000099)2.86406342
34Abnormal delayed hypersensitivity skin test (HP:0002963)2.84138074
35Vasculitis (HP:0002633)2.82308950
36Urinary glycosaminoglycan excretion (HP:0003541)2.75255868
37Mucopolysacchariduria (HP:0008155)2.75255868
38Nephritis (HP:0000123)2.68526366
39Meningitis (HP:0001287)2.68159629
40Interstitial pulmonary disease (HP:0006530)2.65521431
41Abnormality of glycolipid metabolism (HP:0010969)2.65389331
42Abnormality of liposaccharide metabolism (HP:0010968)2.65389331
43Abnormality of glycosphingolipid metabolism (HP:0004343)2.65389331
44Retrobulbar optic neuritis (HP:0100654)2.65305508
45Optic neuritis (HP:0100653)2.65305508
46Abnormality of polysaccharide metabolism (HP:0011012)2.63209188
47Abnormality of glycosaminoglycan metabolism (HP:0004371)2.63209188
48Abnormality of mucopolysaccharide metabolism (HP:0011020)2.63209188
49Basal ganglia calcification (HP:0002135)2.55986296
50Thick nail (HP:0001805)2.55105905
51Prostate neoplasm (HP:0100787)2.52238112
52Periodontitis (HP:0000704)2.51303009
53Colitis (HP:0002583)2.47476523
54Abnormality of complement system (HP:0005339)2.43771708
55Pustule (HP:0200039)2.43745222
56Encephalitis (HP:0002383)2.43601460
57Pulmonary infiltrates (HP:0002113)2.37195372
58Abnormality of T cells (HP:0002843)2.36643894
59Esophageal varix (HP:0002040)2.36340526
60IgA deficiency (HP:0002720)2.36017767
61Leukocytosis (HP:0001974)2.35583238
62Osteolytic defects of the phalanges of the hand (HP:0009771)2.35060712
63Osteolytic defects of the hand bones (HP:0009699)2.35060712
64Gangrene (HP:0100758)2.32161324
65Arterial thrombosis (HP:0004420)2.30966767
66Increased IgM level (HP:0003496)2.30413103
67Anorexia (HP:0002039)2.28588698
68Disinhibition (HP:0000734)2.26953024
69Stomatitis (HP:0010280)2.26637741
70Hemorrhage of the eye (HP:0011885)2.26465111
71Amyloidosis (HP:0011034)2.26038791
72Gingival bleeding (HP:0000225)2.23326683
73Abnormality of the pericardium (HP:0001697)2.22019294
74Gastrointestinal infarctions (HP:0005244)2.19681449
75Chest pain (HP:0100749)2.19072188
76Hypergammaglobulinemia (HP:0010702)2.18031419
77Increased IgE level (HP:0003212)2.16373570
78Spontaneous hematomas (HP:0007420)2.16326901
79Cellulitis (HP:0100658)2.12950057
80Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.11908258
81Recurrent cutaneous fungal infections (HP:0011370)2.11194823
82Chronic mucocutaneous candidiasis (HP:0002728)2.11194823
83Cerebral aneurysm (HP:0004944)2.10640425
84Joint hemorrhage (HP:0005261)2.09300676
85Asymmetric septal hypertrophy (HP:0001670)2.09149358
86Spondylolisthesis (HP:0003302)2.07397924
87Xanthomatosis (HP:0000991)2.07273793
88Porencephaly (HP:0002132)2.06168740
89Abnormality of the pleura (HP:0002103)2.04198034
90Frequent falls (HP:0002359)2.04098486
91Abnormality of the endocardium (HP:0004306)2.03601223
92Increased serum ferritin (HP:0003281)2.02755448
93Autoimmune hemolytic anemia (HP:0001890)2.02589959
94Polycythemia (HP:0001901)2.02539962
95Hand muscle atrophy (HP:0009130)2.02176244
96Gastrointestinal stroma tumor (HP:0100723)2.00932552
97Progressive visual loss (HP:0000529)2.00131273
98Eosinophilia (HP:0001880)1.99650011
99Joint swelling (HP:0001386)1.99122986
100Chronic diarrhea (HP:0002028)1.98881380
101Upper limb amyotrophy (HP:0009129)1.97389465
102Distal upper limb amyotrophy (HP:0007149)1.97389465
103Pulmonary embolism (HP:0002204)1.96454887
104Mitral stenosis (HP:0001718)1.96074567
105Peritonitis (HP:0002586)1.94024747
106Polyneuropathy (HP:0001271)1.93748011
107Arthralgia (HP:0002829)1.93092461
108Recurrent bronchitis (HP:0002837)1.92711442
109Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.91867527
110Cheilitis (HP:0100825)1.91164667
111Inflammation of the large intestine (HP:0002037)1.90949490
112Urticaria (HP:0001025)1.90369545
113Hypercholesterolemia (HP:0003124)1.90261294
114Granulocytopenia (HP:0001913)1.90076325
115Epistaxis (HP:0000421)1.90074099
116Deep venous thrombosis (HP:0002625)1.89041592
117Bone pain (HP:0002653)1.88597277
118Abnormality of T cell physiology (HP:0011840)1.88406316
119Hydroxyprolinuria (HP:0003080)1.88248150
120Abnormality of proline metabolism (HP:0010907)1.88248150
121Increased CSF protein (HP:0002922)1.88135603
122Hemoptysis (HP:0002105)1.88065284
123Keratitis (HP:0000491)1.88047861
124Osteomyelitis (HP:0002754)1.87638771
125Restrictive lung disease (HP:0002091)1.87025702
126Glomerulopathy (HP:0100820)1.86851096
127Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.86363319
128Lymphopenia (HP:0001888)1.83890082
129Emphysema (HP:0002097)1.82326862
130Obstructive lung disease (HP:0006536)1.82104360
131Chronic obstructive pulmonary disease (HP:0006510)1.82104360
132Abnormality of cells of the lymphoid lineage (HP:0012140)1.81801521
133Abnormality of the periventricular white matter (HP:0002518)1.80595197
134Abnormality of the vasculature of the conjunctiva (HP:0008054)1.79645305
135Abnormality of the peritoneum (HP:0002585)1.78619134
136Gastrointestinal inflammation (HP:0004386)1.76868053

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TYK23.72326375
2TBK13.28338747
3MAP3K143.24210538
4PRPF4B2.96857878
5IKBKE2.85576293
6JAK12.83944795
7ERN12.62383994
8TAOK32.52089995
9JAK32.46480519
10RIPK42.36773172
11FGFR42.34334827
12EPHB12.29600341
13MST1R2.25862050
14MAP3K132.24884039
15MAP4K12.13393994
16TAOK22.07647763
17RIPK12.00375461
18KIT1.99063162
19TRIB31.87754186
20CAMK1D1.80410986
21IRAK41.74727941
22GRK71.72229573
23IKBKB1.66582971
24KSR21.61433089
25FGFR31.59501865
26BLK1.57856446
27IRAK31.51416468
28CSK1.51138221
29TTN1.47486259
30CAMK1G1.45428741
31TGFBR21.43848288
32TAOK11.43332611
33DDR21.40944091
34JAK21.39451850
35CDC42BPA1.34203103
36BMX1.26034295
37PTK61.24944415
38CHUK1.24627155
39EPHA31.22323131
40MAP3K21.17376334
41MAP3K111.17349943
42HCK1.09944093
43SIK31.04690406
44PKN21.04414575
45CSF1R1.03779654
46DAPK20.98064125
47CDK120.97626174
48SIK10.96270414
49FGR0.95613306
50ZAP700.94482209
51GRK60.90613465
52FES0.86674757
53RET0.86445829
54MAP3K10.85326953
55SYK0.83931171
56PRKD20.81374289
57STK100.80121956
58IRAK20.79277132
59PIK3CA0.78752939
60LCK0.77558832
61NME20.75831071
62MARK30.74589391
63MAP3K90.73788899
64DMPK0.73330301
65PBK0.72962793
66TXK0.72803911
67PRKCH0.69818241
68PTK2B0.67920343
69BMPR20.67430119
70MET0.67316609
71TEC0.66690919
72MAP3K100.66672807
73EGFR0.66653248
74CLK10.66316052
75PIM20.65919957
76SGK30.63551888
77PDPK10.61209720
78NEK90.60792439
79TRPM70.59439701
80CAMKK20.58935455
81MATK0.58826816
82PDK10.58713082
83ADRBK20.58686191
84MAPK70.56736014
85IRAK10.55257168
86MOS0.54689692
87SIK20.54666507
88MELK0.53094233
89TNK20.53015635
90LRRK20.52915803
91LYN0.51898922
92MAP3K50.49119262
93MARK20.49004762
94TLK10.48402384
95ABL10.48233834
96PRKCQ0.47664053
97PDGFRB0.47454908
98FRK0.46947309
99STK30.46343830
100PRKAA20.46263089
101ABL20.46238338
102ICK0.44391376
103PDGFRA0.43484184
104WNK10.43221450
105TIE10.42489217
106PKN10.40653799
107TESK20.40139381
108PIM10.39798260
109PIK3CG0.39565840
110BTK0.39485096
111MAPK110.39150033
112SMG10.38995646
113FYN0.37554003
114CAMKK10.37509112
115PRKD30.37176616
116MAP2K60.36541455
117ITK0.35726481
118MAPKAPK20.35699228
119MAP2K30.35216164
120RPS6KA40.34904926
121GSK3A0.34856932
122PRKCD0.34055043
123KDR0.32961311
124INSRR0.32399919
125CDK60.32323054
126YES10.32085617
127MAP3K30.31503859
128MAP2K10.31280405
129HIPK20.31055620
130MAP3K60.30006700

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.12516240
2Leishmaniasis_Homo sapiens_hsa051402.65242025
3Toll-like receptor signaling pathway_Homo sapiens_hsa046202.50488275
4Osteoclast differentiation_Homo sapiens_hsa043802.08890618
5RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.96620742
6NF-kappa B signaling pathway_Homo sapiens_hsa040641.90142490
7Pertussis_Homo sapiens_hsa051331.87435133
8Influenza A_Homo sapiens_hsa051641.83511963
9Measles_Homo sapiens_hsa051621.76996352
10TNF signaling pathway_Homo sapiens_hsa046681.72622262
11Lysosome_Homo sapiens_hsa041421.71726892
12Allograft rejection_Homo sapiens_hsa053301.71201587
13Malaria_Homo sapiens_hsa051441.69319695
14Caffeine metabolism_Homo sapiens_hsa002321.67819429
15Tuberculosis_Homo sapiens_hsa051521.66236496
16Graft-versus-host disease_Homo sapiens_hsa053321.64809601
17Toxoplasmosis_Homo sapiens_hsa051451.63102503
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.61318611
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.53273537
20B cell receptor signaling pathway_Homo sapiens_hsa046621.47533672
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.43813726
22Legionellosis_Homo sapiens_hsa051341.43369805
23Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.39468813
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.37484865
25Complement and coagulation cascades_Homo sapiens_hsa046101.37288172
26African trypanosomiasis_Homo sapiens_hsa051431.32514864
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31457633
28Hepatitis C_Homo sapiens_hsa051601.30427811
29Nitrogen metabolism_Homo sapiens_hsa009101.28938881
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.23547962
31Chemokine signaling pathway_Homo sapiens_hsa040621.20908782
32Rheumatoid arthritis_Homo sapiens_hsa053231.19332429
33Type II diabetes mellitus_Homo sapiens_hsa049301.18395601
34Adipocytokine signaling pathway_Homo sapiens_hsa049201.18267690
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.18049369
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17721121
37Other glycan degradation_Homo sapiens_hsa005111.15379946
38Herpes simplex infection_Homo sapiens_hsa051681.15259216
39Salmonella infection_Homo sapiens_hsa051321.15045153
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09088110
41Apoptosis_Homo sapiens_hsa042101.08090174
42Antigen processing and presentation_Homo sapiens_hsa046121.08003385
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.05264928
44Amoebiasis_Homo sapiens_hsa051461.01898632
45Type I diabetes mellitus_Homo sapiens_hsa049401.01472115
46Viral myocarditis_Homo sapiens_hsa054160.99464834
47Dorso-ventral axis formation_Homo sapiens_hsa043200.98897721
48Arginine biosynthesis_Homo sapiens_hsa002200.96228056
49Prion diseases_Homo sapiens_hsa050200.95510927
50Phagosome_Homo sapiens_hsa041450.95330773
51PPAR signaling pathway_Homo sapiens_hsa033200.95229833
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94370985
53ABC transporters_Homo sapiens_hsa020100.89527247
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.89121300
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.88666340
56Insulin resistance_Homo sapiens_hsa049310.88494927
57Hepatitis B_Homo sapiens_hsa051610.86887490
58Prolactin signaling pathway_Homo sapiens_hsa049170.86383962
59Shigellosis_Homo sapiens_hsa051310.84054561
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.82920761
61Mineral absorption_Homo sapiens_hsa049780.79007308
62Asthma_Homo sapiens_hsa053100.78533073
63Acute myeloid leukemia_Homo sapiens_hsa052210.77706863
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76869460
65Bladder cancer_Homo sapiens_hsa052190.76048592
66Chronic myeloid leukemia_Homo sapiens_hsa052200.75986427
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74692784
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73705269
69Pancreatic cancer_Homo sapiens_hsa052120.73640824
70Epstein-Barr virus infection_Homo sapiens_hsa051690.72657069
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72243318
72Non-small cell lung cancer_Homo sapiens_hsa052230.70976565
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69054173
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68147659
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65317401
76Hematopoietic cell lineage_Homo sapiens_hsa046400.64127321
77T cell receptor signaling pathway_Homo sapiens_hsa046600.63306046
78Renal cell carcinoma_Homo sapiens_hsa052110.63275245
79Platelet activation_Homo sapiens_hsa046110.62844190
80HTLV-I infection_Homo sapiens_hsa051660.61255611
81Autoimmune thyroid disease_Homo sapiens_hsa053200.61135865
82Bile secretion_Homo sapiens_hsa049760.60852917
83Viral carcinogenesis_Homo sapiens_hsa052030.60491813
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59360266
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56111985
86Small cell lung cancer_Homo sapiens_hsa052220.55685550
87FoxO signaling pathway_Homo sapiens_hsa040680.55104284
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.53976417
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49031152
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48535490
91HIF-1 signaling pathway_Homo sapiens_hsa040660.48493045
92VEGF signaling pathway_Homo sapiens_hsa043700.46001371
93Fatty acid biosynthesis_Homo sapiens_hsa000610.45759981
94Fatty acid degradation_Homo sapiens_hsa000710.44497547
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44473607
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43026185
97Primary immunodeficiency_Homo sapiens_hsa053400.42999072
98Sphingolipid metabolism_Homo sapiens_hsa006000.42978295
99Prostate cancer_Homo sapiens_hsa052150.42651094
100mTOR signaling pathway_Homo sapiens_hsa041500.41098133
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.40637558
102Proteoglycans in cancer_Homo sapiens_hsa052050.40336779
103Endocytosis_Homo sapiens_hsa041440.40146443
104Glycerolipid metabolism_Homo sapiens_hsa005610.38525256
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38361708
106MAPK signaling pathway_Homo sapiens_hsa040100.38297082
107Tryptophan metabolism_Homo sapiens_hsa003800.37950502
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37202955
109Endometrial cancer_Homo sapiens_hsa052130.37064443
110Starch and sucrose metabolism_Homo sapiens_hsa005000.36890625
111GnRH signaling pathway_Homo sapiens_hsa049120.36392917
112Focal adhesion_Homo sapiens_hsa045100.36187919
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33410133
114Notch signaling pathway_Homo sapiens_hsa043300.32506290
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31726180
116ErbB signaling pathway_Homo sapiens_hsa040120.31343405
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29932328
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.29866188
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28599813
120Adherens junction_Homo sapiens_hsa045200.27929939

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