ZNHIT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sequestering of actin monomers (GO:0042989)6.34876940
2DNA deamination (GO:0045006)5.87941945
3behavioral response to nicotine (GO:0035095)5.09373218
4proteasome assembly (GO:0043248)5.02337981
5water-soluble vitamin biosynthetic process (GO:0042364)4.19378152
6chaperone-mediated protein transport (GO:0072321)4.08980904
7regulation of mitochondrial translation (GO:0070129)3.93386660
8protein neddylation (GO:0045116)3.82794058
9indolalkylamine metabolic process (GO:0006586)3.79900970
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.75946487
11negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.75277111
12ATP biosynthetic process (GO:0006754)3.73902921
13regulation of cellular amino acid metabolic process (GO:0006521)3.71472333
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.71045181
15GDP-mannose metabolic process (GO:0019673)3.68259138
16ribosomal small subunit assembly (GO:0000028)3.66729571
17tryptophan catabolic process (GO:0006569)3.66267838
18indole-containing compound catabolic process (GO:0042436)3.66267838
19indolalkylamine catabolic process (GO:0046218)3.66267838
20antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.62895452
21purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.60989580
22viral transcription (GO:0019083)3.60686120
23purine nucleoside triphosphate biosynthetic process (GO:0009145)3.58760498
24DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.58697091
25deoxyribose phosphate biosynthetic process (GO:0046385)3.57270040
262-deoxyribonucleotide biosynthetic process (GO:0009265)3.57270040
27protein complex biogenesis (GO:0070271)3.56534188
28termination of RNA polymerase III transcription (GO:0006386)3.53578051
29transcription elongation from RNA polymerase III promoter (GO:0006385)3.53578051
30intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.47708793
31signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.47708793
32ATP synthesis coupled proton transport (GO:0015986)3.47191500
33energy coupled proton transport, down electrochemical gradient (GO:0015985)3.47191500
34signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.46151086
35signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.46151086
36signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.46151086
37negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.45143489
38negative regulation of ligase activity (GO:0051352)3.45143489
39mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.44955833
40hydrogen ion transmembrane transport (GO:1902600)3.43730160
41SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.42317220
42translational termination (GO:0006415)3.41683168
43kynurenine metabolic process (GO:0070189)3.40844073
44respiratory electron transport chain (GO:0022904)3.40065805
45guanosine-containing compound biosynthetic process (GO:1901070)3.39444540
46positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.39138628
47electron transport chain (GO:0022900)3.38719990
48GTP biosynthetic process (GO:0006183)3.38485928
49translational elongation (GO:0006414)3.38219912
50platelet dense granule organization (GO:0060155)3.37535814
51protein targeting to mitochondrion (GO:0006626)3.34217694
52mitochondrial respiratory chain complex assembly (GO:0033108)3.33965706
53oxidative phosphorylation (GO:0006119)3.33662136
54signal transduction involved in DNA integrity checkpoint (GO:0072401)3.32843619
55signal transduction involved in DNA damage checkpoint (GO:0072422)3.32843619
56signal transduction involved in cell cycle checkpoint (GO:0072395)3.32581869
57regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.32102359
58cotranslational protein targeting to membrane (GO:0006613)3.31237650
59protein targeting to ER (GO:0045047)3.29706621
60respiratory chain complex IV assembly (GO:0008535)3.27690942
61nucleobase-containing small molecule interconversion (GO:0015949)3.24744671
62establishment of protein localization to mitochondrion (GO:0072655)3.23693167
63translation (GO:0006412)3.23665165
64aromatic amino acid family catabolic process (GO:0009074)3.22621415
65protein localization to endoplasmic reticulum (GO:0070972)3.20094317
66NADH dehydrogenase complex assembly (GO:0010257)3.20051691
67mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.20051691
68mitochondrial respiratory chain complex I assembly (GO:0032981)3.20051691
69ribosomal small subunit biogenesis (GO:0042274)3.18253795
70cullin deneddylation (GO:0010388)3.17101497
71proton transport (GO:0015992)3.16905595
72tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.16006281
73RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.16006281
74anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.15582956
75serotonin metabolic process (GO:0042428)3.14881616
76ribonucleoside triphosphate biosynthetic process (GO:0009201)3.14285055
77aldehyde catabolic process (GO:0046185)3.14050905
78indole-containing compound metabolic process (GO:0042430)3.12312245
79aromatic amino acid family metabolic process (GO:0009072)3.11765727
80L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.11285723
81formation of translation preinitiation complex (GO:0001731)3.09746450
82hydrogen transport (GO:0006818)3.09375238
83viral life cycle (GO:0019058)3.08510585
84heme biosynthetic process (GO:0006783)3.08408464
85protein deneddylation (GO:0000338)3.07589899
86mannosylation (GO:0097502)3.06083113
87deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.05788787
88glyoxylate metabolic process (GO:0046487)3.05703537
89heme metabolic process (GO:0042168)3.05143859
90establishment of protein localization to endoplasmic reticulum (GO:0072599)3.03301413
91parturition (GO:0007567)3.02560329
92positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.01764942
93tryptophan metabolic process (GO:0006568)3.01359328
94primary amino compound metabolic process (GO:1901160)2.99793401
95protein localization to mitochondrion (GO:0070585)2.99646233
96UTP biosynthetic process (GO:0006228)2.98180077
97spliceosomal snRNP assembly (GO:0000387)2.97847233
98cellular protein complex disassembly (GO:0043624)2.96395429
99pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.93772913
100translational initiation (GO:0006413)2.93493155
101positive regulation of ligase activity (GO:0051351)2.91878945
102maturation of SSU-rRNA (GO:0030490)2.91494200
103establishment of protein localization to mitochondrial membrane (GO:0090151)2.90407439
104sulfation (GO:0051923)2.87091453
105amine catabolic process (GO:0009310)2.86971705
106cellular biogenic amine catabolic process (GO:0042402)2.86971705
107antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.86731241
108cytochrome complex assembly (GO:0017004)2.85991962
109iron-sulfur cluster assembly (GO:0016226)2.85059914
110metallo-sulfur cluster assembly (GO:0031163)2.85059914
111positive regulation of cell cycle arrest (GO:0071158)2.83862826
112signal peptide processing (GO:0006465)2.81530779
113glucose 6-phosphate metabolic process (GO:0051156)2.81461181
114sperm-egg recognition (GO:0035036)2.80610159
115L-methionine salvage (GO:0071267)2.78528147
116L-methionine biosynthetic process (GO:0071265)2.78528147
117amino acid salvage (GO:0043102)2.78528147
118regulation of cilium movement (GO:0003352)2.75222873
119regulation of cellular amine metabolic process (GO:0033238)2.74737054
120protein-cofactor linkage (GO:0018065)2.74259618
121negative regulation of telomere maintenance (GO:0032205)2.73895741
122erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.73519189
123L-phenylalanine catabolic process (GO:0006559)2.73519189
124regulation of oxidative phosphorylation (GO:0002082)2.73327300
125pseudouridine synthesis (GO:0001522)2.71536081
126deoxyribonucleotide biosynthetic process (GO:0009263)2.71389743
127L-phenylalanine metabolic process (GO:0006558)2.71037333
128erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.71037333
129binding of sperm to zona pellucida (GO:0007339)2.70831826
130positive regulation of fatty acid transport (GO:2000193)2.70759102
131cellular component biogenesis (GO:0044085)2.70267269
132nucleoside diphosphate phosphorylation (GO:0006165)2.70129686
133cellular response to oxygen radical (GO:0071450)2.69638109
134removal of superoxide radicals (GO:0019430)2.69638109
135cellular response to superoxide (GO:0071451)2.69638109
1367-methylguanosine mRNA capping (GO:0006370)2.69063626
137nucleoside triphosphate biosynthetic process (GO:0009142)2.69000835
138positive regulation of prostaglandin secretion (GO:0032308)2.68813714
139positive regulation of icosanoid secretion (GO:0032305)2.66289910
140preassembly of GPI anchor in ER membrane (GO:0016254)2.65294875
141regulation of ubiquitin-protein transferase activity (GO:0051438)2.65199229
142base-excision repair, AP site formation (GO:0006285)2.65076231
143intracellular protein transmembrane import (GO:0044743)2.64154127
144nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.63872003
145GPI anchor metabolic process (GO:0006505)2.56129725
146regulation of triglyceride catabolic process (GO:0010896)2.51599008
147protein complex disassembly (GO:0043241)2.50673666
148nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.50256488
149response to interferon-beta (GO:0035456)2.49955002
150response to misfolded protein (GO:0051788)2.48597643
151synaptic transmission, cholinergic (GO:0007271)2.47476166
152pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.47394175
153cellular ketone body metabolic process (GO:0046950)2.47161587
154ubiquinone biosynthetic process (GO:0006744)2.45322751
155vitamin biosynthetic process (GO:0009110)2.41073493
156C-terminal protein lipidation (GO:0006501)2.39331610
157negative regulation of appetite (GO:0032099)2.39220270

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.83618200
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.82098565
3* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.62998517
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.48505111
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.41698098
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.26881106
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.13430022
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.10396666
9EZH2_22144423_ChIP-Seq_EOC_Human3.09042287
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.04381654
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.90596606
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.82186528
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.46744651
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.45865809
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.41977036
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.39651211
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.37002256
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.29370952
19YY1_21170310_ChIP-Seq_MESCs_Mouse2.25259853
20VDR_23849224_ChIP-Seq_CD4+_Human2.18920459
21XRN2_22483619_ChIP-Seq_HELA_Human2.17780676
22* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.14560456
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.09671648
24DCP1A_22483619_ChIP-Seq_HELA_Human2.07039225
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.06141770
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.04013550
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.03071341
28* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.02872755
29GABP_19822575_ChIP-Seq_HepG2_Human1.99659787
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.99297687
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.97179800
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.96753576
33ZNF274_21170338_ChIP-Seq_K562_Hela1.96141819
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.90201079
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.89514468
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.85279617
37CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.77783721
38IRF1_19129219_ChIP-ChIP_H3396_Human1.75834641
39FOXP3_21729870_ChIP-Seq_TREG_Human1.71470624
40VDR_22108803_ChIP-Seq_LS180_Human1.71399751
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.66482194
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.66035450
43IRF8_22096565_ChIP-ChIP_GC-B_Human1.62915739
44ERA_21632823_ChIP-Seq_H3396_Human1.62227308
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.59366489
46PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.59164960
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.57208855
48EGR1_23403033_ChIP-Seq_LIVER_Mouse1.56233258
49TTF2_22483619_ChIP-Seq_HELA_Human1.55279739
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54711365
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.53777287
52CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.52096072
53CTCF_20526341_ChIP-Seq_ESCs_Human1.50785970
54SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.48751555
55MYC_18940864_ChIP-ChIP_HL60_Human1.47254828
56* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.46591227
57* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46359740
58TAF2_19829295_ChIP-Seq_ESCs_Human1.45929963
59YY1_22570637_ChIP-Seq_MALME-3M_Human1.45715506
60SRY_22984422_ChIP-ChIP_TESTIS_Rat1.45698871
61RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45492789
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.43467678
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.43272960
64E2F1_20622854_ChIP-Seq_HELA_Human1.43031958
65BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.41002744
66CTCF_18555785_ChIP-Seq_MESCs_Mouse1.40494641
67E2F7_22180533_ChIP-Seq_HELA_Human1.38734355
68STAT3_1855785_ChIP-Seq_MESCs_Mouse1.38600016
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37974650
70IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.36797746
71FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.35396294
72TET1_21451524_ChIP-Seq_MESCs_Mouse1.35180746
73CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.35110837
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34537027
75IRF8_21731497_ChIP-ChIP_J774_Mouse1.32614234
76PHF8_20622854_ChIP-Seq_HELA_Human1.32558053
77FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31264385
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.30702861
79ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.28857287
80P68_20966046_ChIP-Seq_HELA_Human1.28406291
81P300_27268052_Chip-Seq_Bcells_Human1.27153836
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26621386
83EZH2_27294783_Chip-Seq_ESCs_Mouse1.25998890
84RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25927983
85HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.25022620
86EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.23984906
87EED_16625203_ChIP-ChIP_MESCs_Mouse1.23829162
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22590835
89ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21286225
90SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21154697
91PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.20769883
92BCL6_27268052_Chip-Seq_Bcells_Human1.19001482
93ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.18811172
94SA1_27219007_Chip-Seq_Bcells_Human1.18787130
95NANOG_20526341_ChIP-Seq_ESCs_Human1.18449821
96TP53_22573176_ChIP-Seq_HFKS_Human1.18260584
97RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.17748862
98CTCF_27219007_Chip-Seq_Bcells_Human1.17289447
99NCOR_22424771_ChIP-Seq_293T_Human1.16395924
100PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.16236693
101VDR_21846776_ChIP-Seq_THP-1_Human1.14993256
102GATA3_21878914_ChIP-Seq_MCF-7_Human1.13991387
103P53_21459846_ChIP-Seq_SAOS-2_Human1.13874880
104CTCF_26484167_Chip-Seq_Bcells_Mouse1.13660710
105PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13625356
106* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13581582
107REST_21632747_ChIP-Seq_MESCs_Mouse1.13081360
108ETV2_25802403_ChIP-Seq_MESCs_Mouse1.12896588
109* ELK1_19687146_ChIP-ChIP_HELA_Human1.12203912
110CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11936243
111RAC3_21632823_ChIP-Seq_H3396_Human1.11813606
112FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11262880
113FOXA1_25329375_ChIP-Seq_VCAP_Human1.11262880
114* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10877869
115MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09709669
116NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09492966
117ELF1_20517297_ChIP-Seq_JURKAT_Human1.09215616
118NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07677681
119MYC_19829295_ChIP-Seq_ESCs_Human1.06996965
120EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.06898966
121* SPI1_23547873_ChIP-Seq_NB4_Human1.06596891
122JARID2_20075857_ChIP-Seq_MESCs_Mouse1.06390040
123PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04869446
124EZH2_27304074_Chip-Seq_ESCs_Mouse1.04461650
125TDRD3_21172665_ChIP-Seq_MCF-7_Human1.04187051
126OCT4_20526341_ChIP-Seq_ESCs_Human1.04051428
127BCOR_27268052_Chip-Seq_Bcells_Human1.03651956
128MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.03620041
129SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03453715
130MYCN_18555785_ChIP-Seq_MESCs_Mouse1.02320788
131STAT1_20625510_ChIP-Seq_HELA_Human1.01880765
132SOX2_21211035_ChIP-Seq_LN229_Human1.01116513
133BP1_19119308_ChIP-ChIP_Hs578T_Human1.00672600
134DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00614333
135AR_20517297_ChIP-Seq_VCAP_Human1.00573397
136SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99480590
137GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99324128
138* FOXP1_21924763_ChIP-Seq_HESCs_Human0.99150986
139RAD21_21589869_ChIP-Seq_MESCs_Mouse0.97680642
140TFEB_21752829_ChIP-Seq_HELA_Human0.96597345
141ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96209683
142RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95702967
143TBX5_21415370_ChIP-Seq_HL-1_Mouse0.94878287
144TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94825513
145MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94348347
146ERG_20517297_ChIP-Seq_VCAP_Human0.94087355
147CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92989734
148* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92715959
149GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92695012
150TP53_20018659_ChIP-ChIP_R1E_Mouse0.92133083
151FOXH1_21741376_ChIP-Seq_ESCs_Human0.92026395
152PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91951425
153MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.91279106
154LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90828924
155CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90772777
156BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.89828806
157JARID2_20064375_ChIP-Seq_MESCs_Mouse0.89723522
158* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88997598

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.07948903
2MP0002139_abnormal_hepatobiliary_system3.87601159
3MP0005410_abnormal_fertilization3.73937064
4MP0003186_abnormal_redox_activity3.59059079
5MP0003806_abnormal_nucleotide_metabolis3.33509076
6MP0003011_delayed_dark_adaptation3.00761621
7MP0006036_abnormal_mitochondrial_physio2.73737492
8MP0002837_dystrophic_cardiac_calcinosis2.65597944
9MP0002876_abnormal_thyroid_physiology2.60056505
10MP0003656_abnormal_erythrocyte_physiolo2.52216481
11MP0006292_abnormal_olfactory_placode2.48227076
12MP0009785_altered_susceptibility_to2.18558712
13MP0003436_decreased_susceptibility_to2.13998023
14MP0002148_abnormal_hypersensitivity_rea2.08238290
15MP0001986_abnormal_taste_sensitivity2.00300580
16MP0003787_abnormal_imprinting1.97299799
17MP0001835_abnormal_antigen_presentation1.94603223
18MP0009840_abnormal_foam_cell1.92666241
19MP0006276_abnormal_autonomic_nervous1.92617611
20MP0005365_abnormal_bile_salt1.87277613
21MP0001968_abnormal_touch/_nociception1.87043503
22MP0008058_abnormal_DNA_repair1.85582271
23MP0005551_abnormal_eye_electrophysiolog1.82530821
24MP0005646_abnormal_pituitary_gland1.80208238
25MP0003646_muscle_fatigue1.77616196
26MP0003191_abnormal_cellular_cholesterol1.77243269
27MP0009333_abnormal_splenocyte_physiolog1.77133012
28MP0005083_abnormal_biliary_tract1.77049339
29MP0002138_abnormal_hepatobiliary_system1.76731005
30MP0001853_heart_inflammation1.71429826
31MP0002132_abnormal_respiratory_system1.71219337
32MP0009697_abnormal_copulation1.70494922
33MP0005025_abnormal_response_to1.69233913
34MP0009379_abnormal_foot_pigmentation1.68017092
35MP0001764_abnormal_homeostasis1.66467858
36MP0008872_abnormal_physiological_respon1.65287493
37MP0004957_abnormal_blastocyst_morpholog1.65120637
38MP0004142_abnormal_muscle_tone1.64252232
39MP0003195_calcinosis1.62074625
40MP0002653_abnormal_ependyma_morphology1.61901321
41MP0002160_abnormal_reproductive_system1.60109810
42MP0009745_abnormal_behavioral_response1.59040654
43MP0008932_abnormal_embryonic_tissue1.58400504
44MP0001545_abnormal_hematopoietic_system1.56121842
45MP0005397_hematopoietic_system_phenotyp1.56121842
46MP0005670_abnormal_white_adipose1.55541664
47MP0003724_increased_susceptibility_to1.55454443
48MP0005636_abnormal_mineral_homeostasis1.54558259
49MP0000358_abnormal_cell_content/1.48690496
50MP0002735_abnormal_chemical_nociception1.46557531
51MP0005319_abnormal_enzyme/_coenzyme1.46207418
52MP0008469_abnormal_protein_level1.45014906
53MP0005000_abnormal_immune_tolerance1.44723419
54MP0002938_white_spotting1.43093392
55MP0005084_abnormal_gallbladder_morpholo1.38996252
56MP0001485_abnormal_pinna_reflex1.38467027
57MP0005058_abnormal_lysosome_morphology1.37805770
58MP0004885_abnormal_endolymph1.37702078
59MP0003077_abnormal_cell_cycle1.36693158
60MP0005332_abnormal_amino_acid1.35950399
61MP0004133_heterotaxia1.35770428
62MP0005075_abnormal_melanosome_morpholog1.34843490
63MP0008875_abnormal_xenobiotic_pharmacok1.34555840
64MP0004145_abnormal_muscle_electrophysio1.34409986
65MP0005360_urolithiasis1.33767003
66MP0002419_abnormal_innate_immunity1.33084231
67MP0006035_abnormal_mitochondrial_morpho1.32528295
68MP0008789_abnormal_olfactory_epithelium1.30551366
69MP0002272_abnormal_nervous_system1.26610904
70MP0000343_altered_response_to1.26371593
71MP0003698_abnormal_male_reproductive1.22838770
72MP0000049_abnormal_middle_ear1.22800992
73MP0002736_abnormal_nociception_after1.21775704
74MP0009046_muscle_twitch1.21329888
75MP0008260_abnormal_autophagy1.20808570
76MP0001919_abnormal_reproductive_system1.20767437
77MP0000749_muscle_degeneration1.20194044
78MP0005423_abnormal_somatic_nervous1.20161052
79MP0005464_abnormal_platelet_physiology1.19512627
80MP0005085_abnormal_gallbladder_physiolo1.18560898
81MP0006082_CNS_inflammation1.18505279
82MP0005671_abnormal_response_to1.17424775
83MP0000858_altered_metastatic_potential1.17170374
84MP0010386_abnormal_urinary_bladder1.17145016
85MP0001929_abnormal_gametogenesis1.17030513
86MP0010094_abnormal_chromosome_stability1.16477731
87MP0001845_abnormal_inflammatory_respons1.16393943
88MP0002405_respiratory_system_inflammati1.16004172
89MP0006072_abnormal_retinal_apoptosis1.14863947
90MP0000372_irregular_coat_pigmentation1.14134337
91MP0003879_abnormal_hair_cell1.11951619
92MP0005379_endocrine/exocrine_gland_phen1.10368830
93MP0005645_abnormal_hypothalamus_physiol1.10366060
94MP0002102_abnormal_ear_morphology1.10158330
95MP0002723_abnormal_immune_serum1.10156434
96MP0005253_abnormal_eye_physiology1.09140291
97MP0000685_abnormal_immune_system1.08212575
98MP0003718_maternal_effect1.07832866
99MP0002064_seizures1.07832203
100MP0000631_abnormal_neuroendocrine_gland1.05787915
101MP0005389_reproductive_system_phenotype1.05626999
102MP0002733_abnormal_thermal_nociception1.05313760
103MP0004130_abnormal_muscle_cell1.02704891
104MP0003111_abnormal_nucleus_morphology1.02212646
105MP0000313_abnormal_cell_death1.02138365
106MP0005195_abnormal_posterior_eye1.01470016
107MP0002751_abnormal_autonomic_nervous1.01209372
108MP0000026_abnormal_inner_ear1.00840493
109MP0001905_abnormal_dopamine_level1.00492753
110MP0005584_abnormal_enzyme/coenzyme_acti1.00363130
111MP0009764_decreased_sensitivity_to0.99717618
112MP0003136_yellow_coat_color0.98172378
113MP0002210_abnormal_sex_determination0.97635560
114MP0004742_abnormal_vestibular_system0.96480065
115MP0002557_abnormal_social/conspecific_i0.96385098
116MP0003252_abnormal_bile_duct0.94142878
117MP0002822_catalepsy0.94064002
118MP0001819_abnormal_immune_cell0.93963621
119MP0002452_abnormal_antigen_presenting0.93523337
120MP0003786_premature_aging0.92594120
121MP0002420_abnormal_adaptive_immunity0.92415951
122MP0001970_abnormal_pain_threshold0.92004005
123MP0002398_abnormal_bone_marrow0.91112983
124MP0009053_abnormal_anal_canal0.90749960
125MP0000490_abnormal_crypts_of0.90720693
126MP0002277_abnormal_respiratory_mucosa0.89810591
127MP0000689_abnormal_spleen_morphology0.89575619
128MP0002752_abnormal_somatic_nervous0.89143238
129MP0003638_abnormal_response/metabolism_0.88891328
130MP0003123_paternal_imprinting0.88841257
131MP0009643_abnormal_urine_homeostasis0.87285431
132MP0000230_abnormal_systemic_arterial0.85847965
133MP0010329_abnormal_lipoprotein_level0.85292538
134MP0001963_abnormal_hearing_physiology0.85047158
135MP0002429_abnormal_blood_cell0.84414376
136MP0002572_abnormal_emotion/affect_behav0.84359260
137MP0001800_abnormal_humoral_immune0.83044072
138MP0002095_abnormal_skin_pigmentation0.82723643
139MP0002638_abnormal_pupillary_reflex0.81303612
140MP0008877_abnormal_DNA_methylation0.80987718
141MP0002019_abnormal_tumor_incidence0.80279016
142MP0005408_hypopigmentation0.80183560
143MP0004019_abnormal_vitamin_homeostasis0.80046292
144MP0005174_abnormal_tail_pigmentation0.79910966
145MP0008007_abnormal_cellular_replicative0.79813363
146MP0000716_abnormal_immune_system0.79677510
147MP0001756_abnormal_urination0.79242966
148MP0004147_increased_porphyrin_level0.78515862
149MP0003878_abnormal_ear_physiology0.78278824
150MP0005377_hearing/vestibular/ear_phenot0.78278824
151MP0002163_abnormal_gland_morphology0.77943485
152MP0001542_abnormal_bone_strength0.77420205
153MP0000681_abnormal_thyroid_gland0.77255384
154MP0001529_abnormal_vocalization0.76748703
155MP0000538_abnormal_urinary_bladder0.76469204
156MP0001663_abnormal_digestive_system0.76463209
157MP0001145_abnormal_male_reproductive0.76412797
158MP0002229_neurodegeneration0.74463581
159MP0000678_abnormal_parathyroid_gland0.74394624
160MP0003938_abnormal_ear_development0.73593003
161MP0004043_abnormal_pH_regulation0.72717936

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.87607848
2Abnormal mitochondria in muscle tissue (HP:0008316)4.56972038
3Mitochondrial inheritance (HP:0001427)4.43513232
4Hepatocellular necrosis (HP:0001404)4.37824668
5Acute encephalopathy (HP:0006846)4.19142557
6Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.15017223
7Decreased activity of mitochondrial respiratory chain (HP:0008972)4.15017223
8Hepatic necrosis (HP:0002605)4.11198712
9Increased CSF lactate (HP:0002490)3.92005769
10Progressive macrocephaly (HP:0004481)3.79903332
11Abnormality of cells of the erythroid lineage (HP:0012130)3.39646575
12Abnormality of midbrain morphology (HP:0002418)3.34111480
13Molar tooth sign on MRI (HP:0002419)3.34111480
14Cerebral edema (HP:0002181)3.23791682
15Abnormal number of erythroid precursors (HP:0012131)3.19521931
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.18866115
17Congenital stationary night blindness (HP:0007642)3.15810796
18Pancreatic cysts (HP:0001737)3.12596463
19Lactic acidosis (HP:0003128)3.11194169
20Myokymia (HP:0002411)3.05882855
213-Methylglutaconic aciduria (HP:0003535)3.01032351
22Increased serum lactate (HP:0002151)3.00331458
23Abnormality of aromatic amino acid family metabolism (HP:0004338)2.98316533
24Abnormal gallbladder physiology (HP:0012438)2.95825496
25Cholecystitis (HP:0001082)2.95825496
26Respiratory failure (HP:0002878)2.95539584
27Pancreatic fibrosis (HP:0100732)2.91110602
28Pendular nystagmus (HP:0012043)2.90633392
29True hermaphroditism (HP:0010459)2.80986680
30Increased hepatocellular lipid droplets (HP:0006565)2.80657338
31Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.77836771
32Lipid accumulation in hepatocytes (HP:0006561)2.77590961
33Recurrent gram-negative bacterial infections (HP:0005420)2.74725919
34Exercise intolerance (HP:0003546)2.72233027
35Exertional dyspnea (HP:0002875)2.71343019
36Abnormality of alanine metabolism (HP:0010916)2.70790494
37Hyperalaninemia (HP:0003348)2.70790494
38Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.70790494
39Decreased electroretinogram (ERG) amplitude (HP:0000654)2.68761942
40Congenital, generalized hypertrichosis (HP:0004540)2.66915934
41Abolished electroretinogram (ERG) (HP:0000550)2.64174321
42Absent rod-and cone-mediated responses on ERG (HP:0007688)2.62995360
43Increased intramyocellular lipid droplets (HP:0012240)2.60508089
44Aplastic anemia (HP:0001915)2.58505764
45Abnormal ciliary motility (HP:0012262)2.57148162
46Type I transferrin isoform profile (HP:0003642)2.57072919
47Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.57018085
48Recurrent abscess formation (HP:0002722)2.57012148
49Renal Fanconi syndrome (HP:0001994)2.52103983
50Increased muscle lipid content (HP:0009058)2.51363986
51Hyperglycinemia (HP:0002154)2.51258857
52Leukodystrophy (HP:0002415)2.50390792
53Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.50116561
54Nasal polyposis (HP:0100582)2.49659975
55CNS demyelination (HP:0007305)2.47654205
56Recurrent bacterial skin infections (HP:0005406)2.42706771
57Abnormality of the anterior horn cell (HP:0006802)2.40878052
58Degeneration of anterior horn cells (HP:0002398)2.40878052
59Lethargy (HP:0001254)2.36978206
60Abnormality of urine glucose concentration (HP:0011016)2.33260618
61Glycosuria (HP:0003076)2.33260618
62Reduced antithrombin III activity (HP:0001976)2.31786974
63Cerebral hypomyelination (HP:0006808)2.31762660
64Abnormal rod and cone electroretinograms (HP:0008323)2.30117127
65Muscle fiber atrophy (HP:0100295)2.28684808
66Nephronophthisis (HP:0000090)2.27673399
67Hypothermia (HP:0002045)2.26409485
68Methylmalonic aciduria (HP:0012120)2.26325581
69Stenosis of the external auditory canal (HP:0000402)2.22394147
70Concave nail (HP:0001598)2.22382514
71Optic disc pallor (HP:0000543)2.19726989
72Sclerocornea (HP:0000647)2.19207575
73Hypokinesia (HP:0002375)2.17433162
74Chronic bronchitis (HP:0004469)2.17194300
75Emotional lability (HP:0000712)2.16339739
76Poor head control (HP:0002421)2.16258870
77Nausea (HP:0002018)2.14381119
78Eczematoid dermatitis (HP:0000976)2.12289997
79Abnormality of pyrimidine metabolism (HP:0004353)2.12010891
80Type 2 muscle fiber atrophy (HP:0003554)2.11626275
81Abnormal respiratory motile cilium physiology (HP:0012261)2.11427193
82Ketosis (HP:0001946)2.07529312
83Poor suck (HP:0002033)2.06805504
84Male pseudohermaphroditism (HP:0000037)2.05398821
85Reticulocytopenia (HP:0001896)2.04449670
86Severe muscular hypotonia (HP:0006829)2.04351679
87Abnormality of renal resorption (HP:0011038)2.03368160
88Medial flaring of the eyebrow (HP:0010747)2.03138952
89Vacuolated lymphocytes (HP:0001922)2.02682469
90Mediastinal lymphadenopathy (HP:0100721)2.02334361
91Aplasia/Hypoplasia of the sacrum (HP:0008517)2.01645925
92Severe visual impairment (HP:0001141)1.99977938
93Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.99647325
94Neoplasm of head and neck (HP:0012288)1.99142096
95Esophageal neoplasm (HP:0100751)1.99142096
96Cerebral palsy (HP:0100021)1.98950848
97Abnormal respiratory epithelium morphology (HP:0012253)1.98550182
98Abnormal respiratory motile cilium morphology (HP:0005938)1.98550182
99Neuroendocrine neoplasm (HP:0100634)1.98449815
100Hyperphosphaturia (HP:0003109)1.95476662
101Abnormality of fatty-acid metabolism (HP:0004359)1.94189087
102Abnormality of the nasal mucosa (HP:0000433)1.93120899
103Abnormality of macrophages (HP:0004311)1.91826809
104Abnormality of dicarboxylic acid metabolism (HP:0010995)1.91518363
105Dicarboxylic aciduria (HP:0003215)1.91518363
106Rough bone trabeculation (HP:0100670)1.91396899
107Microretrognathia (HP:0000308)1.90946555
108Oral leukoplakia (HP:0002745)1.88923188
109Macrocytic anemia (HP:0001972)1.88805337
110Vertebral compression fractures (HP:0002953)1.88485036
111Generalized aminoaciduria (HP:0002909)1.88384699
112Pallor (HP:0000980)1.88165915
113Abnormality of serum amino acid levels (HP:0003112)1.87886715
114Chorioretinal atrophy (HP:0000533)1.86943005
115Abnormality of glycolysis (HP:0004366)1.86698141
116Increased serum pyruvate (HP:0003542)1.86698141
117Type II lissencephaly (HP:0007260)1.85788656
118Myotonia (HP:0002486)1.85465606
119Elevated erythrocyte sedimentation rate (HP:0003565)1.85417014
120Cleft eyelid (HP:0000625)1.84955498
121Cystic liver disease (HP:0006706)1.84712465
122Hyperbilirubinemia (HP:0002904)1.83497462
123Tongue fasciculations (HP:0001308)1.82723067
124Delusions (HP:0000746)1.82455829
125Dysautonomia (HP:0002459)1.82351853
126Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.80918299
127Abnormal protein N-linked glycosylation (HP:0012347)1.80918299
128Abnormal protein glycosylation (HP:0012346)1.80918299
129Abnormal glycosylation (HP:0012345)1.80918299
130Amniotic constriction ring (HP:0009775)1.80391386
131Abnormality of placental membranes (HP:0011409)1.80391386
132Abnormality of magnesium homeostasis (HP:0004921)1.80257425
133Absent/shortened dynein arms (HP:0200106)1.79809903
134Dynein arm defect of respiratory motile cilia (HP:0012255)1.79809903
135Congenital sensorineural hearing impairment (HP:0008527)1.79588560
136Hypoplasia of the uterus (HP:0000013)1.77045652
137Agitation (HP:0000713)1.76896061
138Pancytopenia (HP:0001876)1.76182963
139Methylmalonic acidemia (HP:0002912)1.76096235
140Respiratory difficulties (HP:0002880)1.75946914
141Opisthotonus (HP:0002179)1.75267432
142Short femoral neck (HP:0100864)1.74390506
143Abnormality of the renal medulla (HP:0100957)1.74066703
144Bony spicule pigmentary retinopathy (HP:0007737)1.73583220
145Metabolic acidosis (HP:0001942)1.73145330
146Attenuation of retinal blood vessels (HP:0007843)1.73041189
147X-linked dominant inheritance (HP:0001423)1.71898965
148Aplasia/Hypoplasia of the tibia (HP:0005772)1.71430327
149Blindness (HP:0000618)1.70629031
150Aplasia/hypoplasia of the uterus (HP:0008684)1.69936909
151Abnormal hemoglobin (HP:0011902)1.68119909
152Increased corneal curvature (HP:0100692)1.67376187
153Keratoconus (HP:0000563)1.67376187
154Alkalosis (HP:0001948)1.67163423
155Hyperthyroidism (HP:0000836)1.65989764

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK14.84119039
2PIM23.99444291
3NME23.94567928
4FRK3.61722403
5TLK13.48554440
6TESK23.35839731
7STK163.23911911
8BUB13.07687877
9VRK22.92265627
10ARAF2.82969913
11GRK12.64163170
12BMPR1B2.50066689
13LIMK12.43736568
14MAP3K112.07348198
15EIF2AK11.93818575
16BRAF1.91070192
17BLK1.75955632
18GRK51.74538064
19NME11.69168992
20BCKDK1.61193207
21SIK31.59642902
22MAP4K21.58735019
23IRAK41.50093037
24MUSK1.46133831
25TBK11.42744222
26TXK1.41181410
27IRAK31.41140330
28CCNB11.37645990
29TAOK31.34427410
30EIF2AK31.33858017
31VRK11.33329807
32PBK1.31974222
33NUAK11.31312460
34WEE11.26655808
35PLK41.25659759
36MAP3K121.24789854
37ABL21.20199884
38NEK11.18075607
39OXSR11.17788866
40WNK31.17182682
41DAPK11.15260771
42ADRBK11.15217550
43INSRR1.14986248
44MAP2K71.14030322
45KDR1.14015419
46PDK41.13334680
47PDK31.13334680
48DAPK31.11616523
49MAPK131.06966993
50PTK2B1.05715797
51ERN11.05638139
52PRKCI1.02993998
53DYRK30.97806876
54EPHB20.93361374
55ZAP700.91372720
56CDK190.91036822
57PAK10.90218307
58MAP4K10.89846766
59CSNK1G30.89495267
60PINK10.87495828
61ADRBK20.87229399
62AURKA0.85901024
63MAPKAPK30.85487385
64RPS6KA40.85182334
65IKBKB0.84553156
66TIE10.84541584
67PDK20.84432112
68MYLK0.84186888
69IRAK10.82905926
70PRKCG0.81603827
71TNK20.80202781
72PIM10.79992486
73ILK0.78917608
74MAPK150.78734463
75CSNK1G20.77179170
76PHKG10.76890308
77PHKG20.76890308
78DYRK20.75299065
79TSSK60.73758096
80CSNK2A10.67640597
81MATK0.66175277
82GRK60.65711481
83MAP2K20.63540475
84TYK20.63214193
85RPS6KA60.63156459
86PIK3CG0.61736501
87CSNK1A1L0.61438871
88CSNK1G10.58974150
89MST40.58938336
90SYK0.58485485
91PRKCQ0.58342506
92PLK10.57521875
93CDK70.57323900
94CAMKK20.56676538
95PIK3CA0.56637374
96RPS6KC10.56489151
97RPS6KL10.56489151
98PRKACA0.56022899
99PAK40.55595548
100ZAK0.54636382
101CSNK1A10.54488580
102UHMK10.53629635
103WNK40.52898942
104IRAK20.52562065
105MAP2K60.52468235
106GRK70.50570820
107CASK0.49892452
108MAPK40.49743012
109IKBKE0.49394199
110KIT0.49254925
111SIK20.49204175
112BTK0.48175854
113PRKCA0.47994772
114SCYL20.47442957
115DYRK1B0.47338852
116NTRK30.47301656
117RPS6KA20.47057292
118PRKG20.47000216
119PKN10.46660430
120HIPK20.44678630
121LRRK20.43022844
122FLT30.42107925
123BRSK10.41714235
124PRKCD0.41442770
125PRKD20.41054970
126NEK20.40891758
127CSNK2A20.40382432
128CDK80.39835812
129EPHA20.39522720
130BRSK20.39495021
131STK110.39393109
132PAK30.39234699
133CAMK2G0.39102719
134ACVR1B0.38175125
135MAP2K30.37528636
136CAMK2A0.37402270
137NTRK20.36965765
138MAP3K10.36691733
139PRKCE0.36271648
140TEC0.35349773
141LYN0.35000212
142MAPKAPK50.34821976
143MAP3K20.33763069
144PASK0.32188059
145ATR0.32141731
146RPS6KA50.32115824
147TAOK20.30971639
148DAPK20.30076574
149RPS6KB20.29889553
150PRKCZ0.28275602

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.49374542
2Ribosome_Homo sapiens_hsa030104.04878325
3Oxidative phosphorylation_Homo sapiens_hsa001903.82374643
4Parkinsons disease_Homo sapiens_hsa050123.41770961
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.70825652
6RNA polymerase_Homo sapiens_hsa030202.66095465
7Huntingtons disease_Homo sapiens_hsa050162.65971731
8DNA replication_Homo sapiens_hsa030302.50476381
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.26468235
10Pyrimidine metabolism_Homo sapiens_hsa002402.25398008
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.19619791
12Protein export_Homo sapiens_hsa030602.14834331
13Alzheimers disease_Homo sapiens_hsa050102.14736528
14Sulfur relay system_Homo sapiens_hsa041221.91902412
15Base excision repair_Homo sapiens_hsa034101.88178150
16Mismatch repair_Homo sapiens_hsa034301.87611062
17Tryptophan metabolism_Homo sapiens_hsa003801.87567638
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.84853305
19Folate biosynthesis_Homo sapiens_hsa007901.78982044
20Spliceosome_Homo sapiens_hsa030401.67578363
21Collecting duct acid secretion_Homo sapiens_hsa049661.66595533
22Caffeine metabolism_Homo sapiens_hsa002321.65094220
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.59488341
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.58236911
25Retinol metabolism_Homo sapiens_hsa008301.57121320
26Linoleic acid metabolism_Homo sapiens_hsa005911.53463926
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.49043593
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.47779459
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.44071195
30Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.40537854
31Fructose and mannose metabolism_Homo sapiens_hsa000511.37228548
32Phototransduction_Homo sapiens_hsa047441.34127696
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.32406484
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28007689
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27493704
36Pentose phosphate pathway_Homo sapiens_hsa000301.26371500
37Homologous recombination_Homo sapiens_hsa034401.23785887
38Butanoate metabolism_Homo sapiens_hsa006501.21641802
39Glutathione metabolism_Homo sapiens_hsa004801.21386857
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.20823475
41Nucleotide excision repair_Homo sapiens_hsa034201.20711073
42Pyruvate metabolism_Homo sapiens_hsa006201.20668461
43Purine metabolism_Homo sapiens_hsa002301.17674145
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.17274621
45Carbon metabolism_Homo sapiens_hsa012001.15567629
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12634855
47Fatty acid elongation_Homo sapiens_hsa000621.11785494
48RNA transport_Homo sapiens_hsa030131.11204486
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.06694187
50Peroxisome_Homo sapiens_hsa041461.05712018
51Galactose metabolism_Homo sapiens_hsa000521.05043849
52Legionellosis_Homo sapiens_hsa051341.04469847
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.02019454
54Drug metabolism - other enzymes_Homo sapiens_hsa009831.02000737
55Vibrio cholerae infection_Homo sapiens_hsa051101.00189021
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.99218373
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94505319
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94325567
59Cardiac muscle contraction_Homo sapiens_hsa042600.92539722
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91723891
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91290211
62Biosynthesis of amino acids_Homo sapiens_hsa012300.91282467
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90897737
64Nitrogen metabolism_Homo sapiens_hsa009100.90735423
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88461823
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.88048413
67Phagosome_Homo sapiens_hsa041450.87798636
68Rheumatoid arthritis_Homo sapiens_hsa053230.87661111
69Regulation of autophagy_Homo sapiens_hsa041400.86585243
70Primary immunodeficiency_Homo sapiens_hsa053400.83967897
71Fat digestion and absorption_Homo sapiens_hsa049750.83851162
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.83235779
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.82899620
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81454359
75Metabolic pathways_Homo sapiens_hsa011000.80995925
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80745572
77Fanconi anemia pathway_Homo sapiens_hsa034600.79149991
78Basal transcription factors_Homo sapiens_hsa030220.77735941
79Synaptic vesicle cycle_Homo sapiens_hsa047210.77274639
80Sulfur metabolism_Homo sapiens_hsa009200.73902470
81One carbon pool by folate_Homo sapiens_hsa006700.72972507
82Epstein-Barr virus infection_Homo sapiens_hsa051690.68705255
83Selenocompound metabolism_Homo sapiens_hsa004500.68025919
84Phenylalanine metabolism_Homo sapiens_hsa003600.66163690
85Glycerolipid metabolism_Homo sapiens_hsa005610.65436167
86Propanoate metabolism_Homo sapiens_hsa006400.61783139
87Nicotine addiction_Homo sapiens_hsa050330.60260043
88Mineral absorption_Homo sapiens_hsa049780.59197252
89Histidine metabolism_Homo sapiens_hsa003400.59075017
90Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56474830
91Vitamin B6 metabolism_Homo sapiens_hsa007500.56420188
92Arginine and proline metabolism_Homo sapiens_hsa003300.54545063
93Pertussis_Homo sapiens_hsa051330.54468796
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51663009
95Ether lipid metabolism_Homo sapiens_hsa005650.50812663
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50727592
97Olfactory transduction_Homo sapiens_hsa047400.50279146
98Tyrosine metabolism_Homo sapiens_hsa003500.49916087
99Graft-versus-host disease_Homo sapiens_hsa053320.47002680
100Other glycan degradation_Homo sapiens_hsa005110.46957327
101RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46920601
102Fatty acid degradation_Homo sapiens_hsa000710.46915834
103Leishmaniasis_Homo sapiens_hsa051400.46743059
104Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46433074
105Morphine addiction_Homo sapiens_hsa050320.45290151
106Staphylococcus aureus infection_Homo sapiens_hsa051500.44101925
107Shigellosis_Homo sapiens_hsa051310.43651925
108Asthma_Homo sapiens_hsa053100.42933256
109Starch and sucrose metabolism_Homo sapiens_hsa005000.42595404
110Autoimmune thyroid disease_Homo sapiens_hsa053200.41743212
111Chemical carcinogenesis_Homo sapiens_hsa052040.41663996
112Systemic lupus erythematosus_Homo sapiens_hsa053220.41597859
113Vitamin digestion and absorption_Homo sapiens_hsa049770.41551042
114Allograft rejection_Homo sapiens_hsa053300.40409429
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39914718
116Salmonella infection_Homo sapiens_hsa051320.39430524
117Arachidonic acid metabolism_Homo sapiens_hsa005900.39427587
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38736468
119Lysosome_Homo sapiens_hsa041420.38510358
120Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38486268
121RNA degradation_Homo sapiens_hsa030180.38134700
122N-Glycan biosynthesis_Homo sapiens_hsa005100.36866988
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35591913
124PPAR signaling pathway_Homo sapiens_hsa033200.35021663
125Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.34690681
126Maturity onset diabetes of the young_Homo sapiens_hsa049500.33835438
127Cell cycle_Homo sapiens_hsa041100.32878880
128Alcoholism_Homo sapiens_hsa050340.32139603
129Fatty acid metabolism_Homo sapiens_hsa012120.31584104
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.31383338
131beta-Alanine metabolism_Homo sapiens_hsa004100.31138268
132Tuberculosis_Homo sapiens_hsa051520.30853451
133Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30546183
134p53 signaling pathway_Homo sapiens_hsa041150.30484913
135Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29906728
136Apoptosis_Homo sapiens_hsa042100.28326415
137Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.25979109
138Serotonergic synapse_Homo sapiens_hsa047260.25093032

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