ZNHIT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)9.57254437
2fusion of sperm to egg plasma membrane (GO:0007342)8.68554402
3acrosome reaction (GO:0007340)8.63638398
4sperm-egg recognition (GO:0035036)8.44209540
5cell wall macromolecule metabolic process (GO:0044036)8.35265645
6cell wall macromolecule catabolic process (GO:0016998)8.35265645
7binding of sperm to zona pellucida (GO:0007339)8.09917594
8acrosome assembly (GO:0001675)7.54100510
9cell-cell recognition (GO:0009988)7.50563902
10spermatid development (GO:0007286)7.01803689
11motile cilium assembly (GO:0044458)6.88469530
12DNA deamination (GO:0045006)6.73993069
13axonemal dynein complex assembly (GO:0070286)6.62706618
14multicellular organism reproduction (GO:0032504)6.53329020
15plasma membrane fusion (GO:0045026)6.50274196
16GDP-mannose metabolic process (GO:0019673)6.38889416
17regulation of cilium movement (GO:0003352)6.16076878
18epithelial cilium movement (GO:0003351)6.14250232
19reproduction (GO:0000003)5.88399133
20cilium or flagellum-dependent cell motility (GO:0001539)5.83888003
21synaptonemal complex organization (GO:0070193)5.57257912
22synaptonemal complex assembly (GO:0007130)5.48022579
23negative regulation of inclusion body assembly (GO:0090084)5.35645820
24regulation of inclusion body assembly (GO:0090083)5.28539602
25piRNA metabolic process (GO:0034587)5.23008435
26male meiosis (GO:0007140)5.10889221
27metallo-sulfur cluster assembly (GO:0031163)5.09010193
28iron-sulfur cluster assembly (GO:0016226)5.09010193
29organic cation transport (GO:0015695)5.05715642
30cilium movement (GO:0003341)4.85574327
31chromosome condensation (GO:0030261)4.80507667
32spermatogenesis (GO:0007283)4.76559017
33male gamete generation (GO:0048232)4.75304758
34single fertilization (GO:0007338)4.72779094
35UV protection (GO:0009650)4.66185976
36sperm capacitation (GO:0048240)4.46390517
37pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.43665476
38DNA packaging (GO:0006323)4.42623614
39epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.42432156
40ribosomal small subunit biogenesis (GO:0042274)4.41463466
41base-excision repair, AP site formation (GO:0006285)4.40983711
42glycerol ether metabolic process (GO:0006662)4.40425139
43proline biosynthetic process (GO:0006561)4.39967969
44sequestering of actin monomers (GO:0042989)4.37574093
45gamete generation (GO:0007276)4.33734863
46rRNA modification (GO:0000154)4.33022469
47purine deoxyribonucleotide catabolic process (GO:0009155)4.20664735
48negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.13468677
49chaperone-mediated protein complex assembly (GO:0051131)4.10202040
50fertilization (GO:0009566)4.09592564
51ether metabolic process (GO:0018904)4.01076251
52deoxyribonucleotide catabolic process (GO:0009264)4.00451795
53male meiosis I (GO:0007141)4.00028461
54negative regulation of cell aging (GO:0090344)3.95173161
55negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.90623021
56meiosis I (GO:0007127)3.77301687
57deoxyribose phosphate catabolic process (GO:0046386)3.75150782
58protein maturation by protein folding (GO:0022417)3.74261006
59microtubule depolymerization (GO:0007019)3.72657223
60germ cell development (GO:0007281)3.72001292
61nucleotide salvage (GO:0043173)3.70527298
62regulation of microtubule-based movement (GO:0060632)3.69310932
63rRNA methylation (GO:0031167)3.66329032
64ribosome biogenesis (GO:0042254)3.63820635
65cellular process involved in reproduction in multicellular organism (GO:0022412)3.61214488
66sexual reproduction (GO:0019953)3.61144530
67pyrimidine nucleotide catabolic process (GO:0006244)3.60546443
68pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.52314476
69chromosome organization involved in meiosis (GO:0070192)3.51309897
70meiotic nuclear division (GO:0007126)3.50305577
71microtubule severing (GO:0051013)3.50268254
72calcium ion-dependent exocytosis (GO:0017156)3.48996955
73regulation of cytokine production involved in inflammatory response (GO:1900015)3.45847142
74pseudouridine synthesis (GO:0001522)3.43217767
75protein retention in ER lumen (GO:0006621)3.37698838
76ribonucleoprotein complex biogenesis (GO:0022613)3.37015426
77regulation of mitochondrial translation (GO:0070129)3.36953476
78multicellular organismal reproductive process (GO:0048609)3.35475944
79polyamine biosynthetic process (GO:0006596)3.27923625
80mitochondrial calcium ion transport (GO:0006851)3.26191560
81negative regulation of B cell apoptotic process (GO:0002903)3.24499836
82DNA methylation involved in gamete generation (GO:0043046)3.24458673
83seminiferous tubule development (GO:0072520)3.20939360
84regulation of mammary gland epithelial cell proliferation (GO:0033599)3.19391316
85single strand break repair (GO:0000012)3.18412241
86ubiquinone biosynthetic process (GO:0006744)3.17572070
87GTP biosynthetic process (GO:0006183)3.13740487
88tRNA methylation (GO:0030488)3.13043328
89mitotic cell cycle arrest (GO:0071850)3.13032153
902-deoxyribonucleotide metabolic process (GO:0009394)3.11448499
91peptidyl-arginine omega-N-methylation (GO:0035247)3.10284227
92chaperone-mediated protein transport (GO:0072321)3.08935407
93tRNA modification (GO:0006400)3.08875998
94meiotic cell cycle (GO:0051321)3.06202701
95maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.04095781
96DNA strand renaturation (GO:0000733)3.00645029
97cellular component biogenesis (GO:0044085)3.00329651
98pyrimidine nucleoside salvage (GO:0043097)2.99547960
99pyrimidine-containing compound salvage (GO:0008655)2.99547960
100interferon-gamma secretion (GO:0072643)2.99425257
101grooming behavior (GO:0007625)2.97975741
102cell recognition (GO:0008037)2.97663800
103UTP biosynthetic process (GO:0006228)2.97383631
104protein refolding (GO:0042026)2.96973856
105spermatid nucleus differentiation (GO:0007289)2.96307381
106protein localization to chromosome, centromeric region (GO:0071459)2.94064725
107purine nucleotide salvage (GO:0032261)2.93189100
108peptidyl-histidine modification (GO:0018202)2.93052966
109protein polyglutamylation (GO:0018095)2.91846013
110NIK/NF-kappaB signaling (GO:0038061)2.91527817
111protein complex localization (GO:0031503)2.90676935
112mitochondrial fusion (GO:0008053)2.87644853
113deoxyribose phosphate biosynthetic process (GO:0046385)2.87402367
1142-deoxyribonucleotide biosynthetic process (GO:0009265)2.87402367
115nucleoside diphosphate phosphorylation (GO:0006165)2.84773258
116deoxyribose phosphate metabolic process (GO:0019692)2.84663384
117protein targeting to mitochondrion (GO:0006626)2.84104375
118nucleoside salvage (GO:0043174)2.83333076
119UTP metabolic process (GO:0046051)2.81523637
120guanosine-containing compound biosynthetic process (GO:1901070)2.80961410
121purine deoxyribonucleotide metabolic process (GO:0009151)2.78244893
122regulation of skeletal muscle contraction (GO:0014819)2.78082429
123mitochondrion degradation (GO:0000422)2.77458777
124nucleobase-containing small molecule interconversion (GO:0015949)2.76588704
125establishment of protein localization to mitochondrion (GO:0072655)2.76391909
126multicellular organismal development (GO:0007275)2.76023206
127histone arginine methylation (GO:0034969)2.75507883
128ribosomal small subunit assembly (GO:0000028)2.75239758
129ventricular system development (GO:0021591)2.74731151
130rRNA transcription (GO:0009303)2.74580256
131pyrimidine nucleoside biosynthetic process (GO:0046134)2.74261627
132regulation of spindle checkpoint (GO:0090231)2.74231403
133pyrimidine nucleotide metabolic process (GO:0006220)2.73276449
134DNA strand elongation involved in DNA replication (GO:0006271)2.72671715
135granulocyte differentiation (GO:0030851)2.72110093
136left/right pattern formation (GO:0060972)2.72018668
137ubiquinone metabolic process (GO:0006743)2.71108751
138pyrimidine nucleotide biosynthetic process (GO:0006221)2.68474009
139DNA strand elongation (GO:0022616)2.67473435
140pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.66616936
141proline metabolic process (GO:0006560)2.66442627
142pentose metabolic process (GO:0019321)2.66420881
143negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.65737356
144lipoxygenase pathway (GO:0019372)2.65604080
145telomere maintenance via semi-conservative replication (GO:0032201)2.64970637
146rRNA processing (GO:0006364)2.64673858
147protein insertion into membrane (GO:0051205)2.62728631
148transcription from mitochondrial promoter (GO:0006390)2.62673792
149positive regulation of protein homooligomerization (GO:0032464)2.62442200
150nuclear envelope reassembly (GO:0031468)2.61599654
151mitotic nuclear envelope reassembly (GO:0007084)2.61599654
152negative regulation of DNA-templated transcription, elongation (GO:0032785)2.60829995
153pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.60259394
154amino-acid betaine transport (GO:0015838)2.59682213
155carnitine transport (GO:0015879)2.59682213
156deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.59324559
157modulation by virus of host process (GO:0019054)2.58712107
158base-excision repair (GO:0006284)2.58078605
159ncRNA 3-end processing (GO:0043628)2.57560093
160rRNA catabolic process (GO:0016075)2.57088698
161RNA methylation (GO:0001510)2.57080227
162regulation of translational fidelity (GO:0006450)2.56794380
163DNA unwinding involved in DNA replication (GO:0006268)2.56465439
164CTP metabolic process (GO:0046036)2.56378427
165CTP biosynthetic process (GO:0006241)2.56378427
166translational elongation (GO:0006414)2.54525200
167formation of translation preinitiation complex (GO:0001731)2.52137188
168glycolytic process (GO:0006096)2.50031885
169DNA replication-dependent nucleosome organization (GO:0034723)2.49610970
170DNA replication-dependent nucleosome assembly (GO:0006335)2.49610970
171pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.48207536
172pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.47010147
173viral transcription (GO:0019083)2.46073178
174meiotic cell cycle process (GO:1903046)2.45539611
175carnitine transmembrane transport (GO:1902603)2.44512643
176folic acid metabolic process (GO:0046655)2.42054349
177maturation of SSU-rRNA (GO:0030490)2.41632817
178cell redox homeostasis (GO:0045454)2.39995517
179pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.39386047
180translational termination (GO:0006415)2.38134814
181deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.37230136
182nucleoside diphosphate metabolic process (GO:0009132)2.30425772
183alditol metabolic process (GO:0019400)2.29870690

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.63393145
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.08746636
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.76174629
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.54750575
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.27064580
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.22641748
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.21751472
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.19318877
9* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.15912990
10SRY_22984422_ChIP-ChIP_TESTIS_Rat2.09914197
11* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.01742600
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.97157591
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.80336359
14CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.78419238
15* TET1_21451524_ChIP-Seq_MESCs_Mouse1.75088394
16* ETS1_20019798_ChIP-Seq_JURKAT_Human1.74067070
17* RACK7_27058665_Chip-Seq_MCF-7_Human1.72461703
18ELF1_20517297_ChIP-Seq_JURKAT_Human1.69353928
19THAP11_20581084_ChIP-Seq_MESCs_Mouse1.68085511
20CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.67725552
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.66732607
22BCOR_27268052_Chip-Seq_Bcells_Human1.63707319
23* ELK3_25401928_ChIP-Seq_HUVEC_Human1.62128374
24BCL6_27268052_Chip-Seq_Bcells_Human1.59976152
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.59931633
26YY1_22570637_ChIP-Seq_MALME-3M_Human1.59765559
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57901727
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.55644334
29CIITA_25753668_ChIP-Seq_RAJI_Human1.54488676
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54447143
31* XRN2_22483619_ChIP-Seq_HELA_Human1.52196596
32CTCF_18555785_ChIP-Seq_MESCs_Mouse1.51581252
33E2F7_22180533_ChIP-Seq_HELA_Human1.50700503
34* GABP_19822575_ChIP-Seq_HepG2_Human1.49112694
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.49027502
36CTCF_26484167_Chip-Seq_Bcells_Mouse1.48606047
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48316073
38SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.48147093
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.47086227
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44749071
41ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.44021218
42CTCF_21964334_Chip-Seq_Bcells_Human1.43854923
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.42530456
44BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.42128326
45* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.41635095
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40250268
47EST1_17652178_ChIP-ChIP_JURKAT_Human1.37906332
48* GATA3_21867929_ChIP-Seq_CD8_Mouse1.37716145
49VDR_24763502_ChIP-Seq_THP-1_Human1.37059038
50* KDM5A_27292631_Chip-Seq_BREAST_Human1.35501031
51SMC4_20622854_ChIP-Seq_HELA_Human1.35378587
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.35207838
53* VDR_23849224_ChIP-Seq_CD4+_Human1.34028914
54* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.33600441
55* MAF_26560356_Chip-Seq_TH1_Human1.33257286
56SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.33150615
57MYC_19079543_ChIP-ChIP_MESCs_Mouse1.32766218
58SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32542183
59PHF8_20622854_ChIP-Seq_HELA_Human1.32368711
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31707479
61SOX2_22085726_ChIP-Seq_NPCs_Mouse1.31309217
62* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.31245981
63* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30954950
64PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.30102256
65ZNF263_19887448_ChIP-Seq_K562_Human1.29996441
66NELFA_20434984_ChIP-Seq_ESCs_Mouse1.29569496
67HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.29055983
68UTX_26944678_Chip-Seq_JUKART_Human1.29033795
69CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.28773323
70PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28568818
71* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.28525971
72DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.27717036
73* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27280743
74* VDR_21846776_ChIP-Seq_THP-1_Human1.27247146
75CREB1_15753290_ChIP-ChIP_HEK293T_Human1.26990621
76CTCF_20526341_ChIP-Seq_ESCs_Human1.26421345
77ERG_21242973_ChIP-ChIP_JURKAT_Human1.26377086
78* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.26358712
79HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.24737162
80STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23312147
81* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23186054
82CTCF_21964334_ChIP-Seq_BJAB-B_Human1.23173914
83FOXM1_23109430_ChIP-Seq_U2OS_Human1.22937766
84MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.22463468
85FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.21833563
86* RARA_24833708_ChIP-Seq_LIVER_Mouse1.21365357
87TTF2_22483619_ChIP-Seq_HELA_Human1.21080617
88* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20962102
89* KDM2B_26808549_Chip-Seq_DND41_Human1.20879564
90* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.20653305
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20342659
92LXR_22292898_ChIP-Seq_THP-1_Human1.20306779
93P68_20966046_ChIP-Seq_HELA_Human1.19796149
94RAD21_21589869_ChIP-Seq_MESCs_Mouse1.19517745
95SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18505946
96SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18476676
97PU.1_20513432_ChIP-Seq_Bcells_Mouse1.17461813
98CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16897364
99MYC_22102868_ChIP-Seq_BL_Human1.16247369
100P300_27268052_Chip-Seq_Bcells_Human1.16167209
101PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15712023
102CREB1_26743006_Chip-Seq_LNCaP_Human1.14456940
103* FOXP1_21924763_ChIP-Seq_HESCs_Human1.14198740
104DCP1A_22483619_ChIP-Seq_HELA_Human1.13784599
105* CTCF_27219007_Chip-Seq_Bcells_Human1.13657827
106* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.13364730
107ELF1_17652178_ChIP-ChIP_JURKAT_Human1.12713057
108KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12637048
109* ETS1_21867929_ChIP-Seq_TH2_Mouse1.12440351
110* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.12283705
111P53_21459846_ChIP-Seq_SAOS-2_Human1.11785984
112FOXP3_21729870_ChIP-Seq_TREG_Human1.11213352
113E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.11019454
114* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.10822050
115MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10312050
116* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10257579
117TP53_22127205_ChIP-Seq_IMR90_Human1.10190136
118NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09727045
119LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.09143563
120STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08222277
121SPI1_20517297_ChIP-Seq_HL60_Human1.07897472
122MAF_26560356_Chip-Seq_TH2_Human1.04102393
123SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04066450
124CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03492409
125GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03360262
126CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03345561
127RARB_24833708_ChIP-Seq_LIVER_Mouse1.03175728
128E2F1_20622854_ChIP-Seq_HELA_Human1.03115677
129GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01585965
130PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01542134
131NANOG_20526341_ChIP-Seq_ESCs_Human1.01333923
132* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00162954
133FLI1_21867929_ChIP-Seq_CD8_Mouse0.99901076
134* SRF_21415370_ChIP-Seq_HL-1_Mouse0.99702588
135* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99689095
136BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.99659421
137* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98261264
138SPI1_26923725_Chip-Seq_HPCs_Mouse0.97617717
139SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97607508
140POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.97591130
141SA1_27219007_Chip-Seq_ERYTHROID_Human0.97111377

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive4.25948468
2MP0001929_abnormal_gametogenesis4.18545160
3MP0005451_abnormal_body_composition3.23863084
4MP0009840_abnormal_foam_cell2.69801668
5MP0003693_abnormal_embryo_hatching2.64659769
6MP0003806_abnormal_nucleotide_metabolis2.61504880
7MP0002210_abnormal_sex_determination2.58401993
8MP0001661_extended_life_span2.58133914
9MP0002139_abnormal_hepatobiliary_system2.56047575
10MP0005171_absent_coat_pigmentation2.49307925
11MP0008877_abnormal_DNA_methylation2.49119064
12MP0002161_abnormal_fertility/fecundity2.48849268
13MP0005058_abnormal_lysosome_morphology2.37634220
14MP0000678_abnormal_parathyroid_gland2.34376108
15MP0001145_abnormal_male_reproductive2.32190971
16MP0000750_abnormal_muscle_regeneration2.24024853
17MP0002653_abnormal_ependyma_morphology2.23469641
18MP0005670_abnormal_white_adipose2.23295724
19MP0005423_abnormal_somatic_nervous2.13695329
20MP0005501_abnormal_skin_physiology2.12943165
21MP0004957_abnormal_blastocyst_morpholog2.05800319
22MP0005174_abnormal_tail_pigmentation2.02616482
23MP0005410_abnormal_fertilization11.7476886
24MP0000653_abnormal_sex_gland1.96810651
25MP0001873_stomach_inflammation1.93138631
26MP0009278_abnormal_bone_marrow1.82873559
27MP0005360_urolithiasis1.77696982
28MP0003453_abnormal_keratinocyte_physiol1.72794972
29MP0002160_abnormal_reproductive_system1.72754107
30MP0005330_cardiomyopathy1.70907546
31MP0001188_hyperpigmentation1.67253939
32MP0002163_abnormal_gland_morphology1.66420335
33MP0003111_abnormal_nucleus_morphology1.65505210
34MP0006036_abnormal_mitochondrial_physio1.61987700
35MP0010094_abnormal_chromosome_stability1.60974127
36MP0004858_abnormal_nervous_system1.57932306
37MP0002132_abnormal_respiratory_system1.54794602
38MP0008260_abnormal_autophagy1.51226318
39MP0003646_muscle_fatigue1.49930667
40MP0005636_abnormal_mineral_homeostasis1.47005010
41MP0008058_abnormal_DNA_repair1.45707574
42MP0001348_abnormal_lacrimal_gland1.43074797
43MP0001545_abnormal_hematopoietic_system1.39146594
44MP0005397_hematopoietic_system_phenotyp1.39146594
45MP0003186_abnormal_redox_activity1.35289911
46MP0003077_abnormal_cell_cycle1.32174710
47MP0005083_abnormal_biliary_tract1.31910571
48MP0000751_myopathy1.31430681
49MP0003315_abnormal_perineum_morphology1.30519143
50MP0000681_abnormal_thyroid_gland1.29760967
51MP0005365_abnormal_bile_salt1.26447978
52MP0004185_abnormal_adipocyte_glucose1.25821854
53MP0000015_abnormal_ear_pigmentation1.25490998
54MP0002796_impaired_skin_barrier1.25124996
55MP0001919_abnormal_reproductive_system1.23225457
56MP0008007_abnormal_cellular_replicative1.22833333
57MP0003329_amyloid_beta_deposits1.21961718
58MP0000685_abnormal_immune_system1.21859130
59MP0001764_abnormal_homeostasis1.19925556
60MP0009379_abnormal_foot_pigmentation1.19861974
61MP0000358_abnormal_cell_content/1.16693839
62MP0000747_muscle_weakness1.16325269
63MP0002148_abnormal_hypersensitivity_rea1.14960715
64MP0005409_darkened_coat_color1.14052200
65MP0003656_abnormal_erythrocyte_physiolo1.13215719
66MP0001346_abnormal_lacrimal_gland1.11665553
67MP0005220_abnormal_exocrine_pancreas1.10713251
68MP0008875_abnormal_xenobiotic_pharmacok1.10346346
69MP0004233_abnormal_muscle_weight1.10303808
70MP0009333_abnormal_splenocyte_physiolog1.09759207
71MP0005076_abnormal_cell_differentiation1.07037054
72MP0005085_abnormal_gallbladder_physiolo1.03829161
73MP0001730_embryonic_growth_arrest1.01442636
74MP0000003_abnormal_adipose_tissue0.98323356
75MP0003763_abnormal_thymus_physiology0.98265459
76MP0002405_respiratory_system_inflammati0.95386429
77MP0001765_abnormal_ion_homeostasis0.94736679
78MP0002398_abnormal_bone_marrow0.94418850
79MP0005319_abnormal_enzyme/_coenzyme0.93721617
80MP0000490_abnormal_crypts_of0.92199704
81MP0001756_abnormal_urination0.91673857
82MP0005584_abnormal_enzyme/coenzyme_acti0.90218107
83MP0009643_abnormal_urine_homeostasis0.90042872
84MP0000689_abnormal_spleen_morphology0.89061260
85MP0001984_abnormal_olfaction0.88207929
86MP0005332_abnormal_amino_acid0.88151015
87MP0001849_ear_inflammation0.87669198
88MP0003191_abnormal_cellular_cholesterol0.86883070
89MP0002019_abnormal_tumor_incidence0.86868294
90MP0006035_abnormal_mitochondrial_morpho0.86526933
91MP0010307_abnormal_tumor_latency0.86175234
92MP0010329_abnormal_lipoprotein_level0.86169353
93MP0003436_decreased_susceptibility_to0.85645752
94MP0009384_cardiac_valve_regurgitation0.85161000
95MP0009931_abnormal_skin_appearance0.85106934
96MP0000313_abnormal_cell_death0.84067926
97MP0005389_reproductive_system_phenotype0.83541452
98MP0003123_paternal_imprinting0.82678933
99MP0002909_abnormal_adrenal_gland0.82468113
100MP0000858_altered_metastatic_potential0.82053369
101MP0009785_altered_susceptibility_to0.81967976
102MP0000604_amyloidosis0.81268361
103MP0000609_abnormal_liver_physiology0.81147565
104MP0005025_abnormal_response_to0.80746519
105MP0002722_abnormal_immune_system0.79996982
106MP0008469_abnormal_protein_level0.79690955
107MP0002429_abnormal_blood_cell0.79589713
108MP0002822_catalepsy0.77040955
109MP0003172_abnormal_lysosome_physiology0.77036529
110MP0004381_abnormal_hair_follicle0.76301774
111MP0005464_abnormal_platelet_physiology0.76079840
112MP0002723_abnormal_immune_serum0.75971197
113MP0005310_abnormal_salivary_gland0.74933666
114MP0000350_abnormal_cell_proliferation0.74868151
115MP0003011_delayed_dark_adaptation0.74862468
116MP0005375_adipose_tissue_phenotype0.74090843
117MP0000716_abnormal_immune_system0.73544327
118MP0003136_yellow_coat_color0.73216135
119MP0001835_abnormal_antigen_presentation0.72976299
120MP0000598_abnormal_liver_morphology0.72517577
121MP0001968_abnormal_touch/_nociception0.72377927
122MP0001502_abnormal_circadian_rhythm0.72257151
123MP0001881_abnormal_mammary_gland0.71988728
124MP0000703_abnormal_thymus_morphology0.70482868
125MP0002249_abnormal_larynx_morphology0.70089585
126MP0005377_hearing/vestibular/ear_phenot0.69982164
127MP0003878_abnormal_ear_physiology0.69982164
128MP0004808_abnormal_hematopoietic_stem0.68773161
129MP0010771_integument_phenotype0.68741223
130MP0005666_abnormal_adipose_tissue0.68110977
131MP0000538_abnormal_urinary_bladder0.67574354
132MP0008932_abnormal_embryonic_tissue0.66618174
133MP0001800_abnormal_humoral_immune0.65885579
134MP0002736_abnormal_nociception_after0.64808752
135MP0002234_abnormal_pharynx_morphology0.64084148
136MP0003786_premature_aging0.63045190
137MP0002080_prenatal_lethality0.62781551
138MP0002420_abnormal_adaptive_immunity0.62561727
139MP0001819_abnormal_immune_cell0.62398100
140MP0009115_abnormal_fat_cell0.61824876
141MP0001845_abnormal_inflammatory_respons0.61346312
142MP0004019_abnormal_vitamin_homeostasis0.60357073
143MP0003195_calcinosis0.60154994
144MP0001853_heart_inflammation0.60102831
145MP0003718_maternal_effect0.58298914
146MP0005671_abnormal_response_to0.58156964
147MP0001986_abnormal_taste_sensitivity0.57433072
148MP0002118_abnormal_lipid_homeostasis0.57397335
149MP0005266_abnormal_metabolism0.56633135
150MP0002970_abnormal_white_adipose0.56536449
151MP0002452_abnormal_antigen_presenting0.55342644

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.73631630
2Absent/shortened dynein arms (HP:0200106)9.27620894
3Dynein arm defect of respiratory motile cilia (HP:0012255)9.27620894
4Nasal polyposis (HP:0100582)6.91157487
5Abnormal respiratory motile cilium morphology (HP:0005938)6.81004711
6Abnormal respiratory epithelium morphology (HP:0012253)6.81004711
7Abnormal respiratory motile cilium physiology (HP:0012261)6.80134012
8Chronic bronchitis (HP:0004469)6.77235130
9Testicular atrophy (HP:0000029)6.46099291
10Rhinitis (HP:0012384)5.90198970
11Abnormality of the nasal mucosa (HP:0000433)5.78533580
12Infertility (HP:0000789)5.69613365
13Bronchitis (HP:0012387)4.88267562
14Abnormal ciliary motility (HP:0012262)4.69379066
15Bronchiectasis (HP:0002110)4.08471432
16Mesangial abnormality (HP:0001966)3.74618176
17Renal Fanconi syndrome (HP:0001994)3.74248134
18Recurrent bronchitis (HP:0002837)3.62289183
19Poikiloderma (HP:0001029)3.49593242
20Dyschromatopsia (HP:0007641)3.48830787
21Ragged-red muscle fibers (HP:0003200)3.44234488
22Male infertility (HP:0003251)3.35320187
23Increased hepatocellular lipid droplets (HP:0006565)3.33592499
24Cholecystitis (HP:0001082)3.27502250
25Abnormal gallbladder physiology (HP:0012438)3.27502250
26Abnormal spermatogenesis (HP:0008669)3.23175263
27Abnormality of cells of the erythroid lineage (HP:0012130)3.22859376
28Abnormal number of erythroid precursors (HP:0012131)3.15253745
29Lipid accumulation in hepatocytes (HP:0006561)3.09570987
30Ulnar bowing (HP:0003031)3.00343927
31Recurrent otitis media (HP:0000403)2.99393783
32Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.98209127
33Vaginal fistula (HP:0004320)2.95043052
34Squamous cell carcinoma (HP:0002860)2.93134497
35Rib fusion (HP:0000902)2.90038786
36Recurrent sinusitis (HP:0011108)2.88050615
37Decreased electroretinogram (ERG) amplitude (HP:0000654)2.86366688
38Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.84167149
39Decreased activity of mitochondrial respiratory chain (HP:0008972)2.84167149
40Increased CSF lactate (HP:0002490)2.71896825
41Thin bony cortex (HP:0002753)2.71456156
42Broad distal phalanx of finger (HP:0009836)2.66005944
43Facial hemangioma (HP:0000329)2.64997078
44Impulsivity (HP:0100710)2.64762668
45Rectal fistula (HP:0100590)2.62801141
46Rectovaginal fistula (HP:0000143)2.62801141
47Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.61416682
48Attenuation of retinal blood vessels (HP:0007843)2.55062554
49Abnormal trabecular bone morphology (HP:0100671)2.49758384
50Intestinal fistula (HP:0100819)2.47297875
51Myopathic facies (HP:0002058)2.45503339
52Exercise intolerance (HP:0003546)2.44802423
53Aplasia of the musculature (HP:0100854)2.39478871
54Aplasia/Hypoplasia of the sacrum (HP:0008517)2.38905491
55Exertional dyspnea (HP:0002875)2.34403580
56Delayed epiphyseal ossification (HP:0002663)2.33285156
57Rhabdomyolysis (HP:0003201)2.32788704
58Rough bone trabeculation (HP:0100670)2.30209425
59Abnormality of the intrinsic pathway (HP:0010989)2.24999932
60Nephronophthisis (HP:0000090)2.24449409
61Bony spicule pigmentary retinopathy (HP:0007737)2.23594151
62Annular pancreas (HP:0001734)2.23458451
63Hypertensive crisis (HP:0100735)2.19863860
64Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.15108002
65Muscle fiber atrophy (HP:0100295)2.15104707
66Microvesicular hepatic steatosis (HP:0001414)2.11369604
67Absent thumb (HP:0009777)2.09754737
68Respiratory difficulties (HP:0002880)2.06776157
69Popliteal pterygium (HP:0009756)2.03687777
70Abnormality of placental membranes (HP:0011409)2.03494952
71Amniotic constriction ring (HP:0009775)2.03494952
72Acute encephalopathy (HP:0006846)2.02775145
73Hand muscle atrophy (HP:0009130)2.00551939
74Choroideremia (HP:0001139)2.00150429
75Azoospermia (HP:0000027)2.00027257
76Abnormality of the lower motor neuron (HP:0002366)1.98321357
77Late onset (HP:0003584)1.96526954
78Chronic sinusitis (HP:0011109)1.94229186
79Reticulocytopenia (HP:0001896)1.92728293
80Abnormality of aromatic amino acid family metabolism (HP:0004338)1.92639732
81Gonadotropin excess (HP:0000837)1.91766399
82Joint stiffness (HP:0001387)1.91494767
83Abnormality of the costochondral junction (HP:0000919)1.89999183
84Progressive muscle weakness (HP:0003323)1.89362172
85Myoglobinuria (HP:0002913)1.88452387
86Oral leukoplakia (HP:0002745)1.87806439
87Atelectasis (HP:0100750)1.87686942
88Distal upper limb amyotrophy (HP:0007149)1.87623821
89Upper limb amyotrophy (HP:0009129)1.87623821
90Abnormal epiphyseal ossification (HP:0010656)1.86993741
91Epiphyseal stippling (HP:0010655)1.86512518
92Abnormality of renal resorption (HP:0011038)1.85303468
93Progressive external ophthalmoplegia (HP:0000590)1.83903212
94Delusions (HP:0000746)1.83413346
95Anteriorly placed anus (HP:0001545)1.82674467
96Neonatal onset (HP:0003623)1.82280604
97Double outlet right ventricle (HP:0001719)1.81294008
98Congenital malformation of the right heart (HP:0011723)1.81294008
99Flat capital femoral epiphysis (HP:0003370)1.80825740
100Chronic otitis media (HP:0000389)1.80473273
101Cholelithiasis (HP:0001081)1.79800678
102Abnormal protein glycosylation (HP:0012346)1.78945636
103Abnormal glycosylation (HP:0012345)1.78945636
104Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.78945636
105Abnormal protein N-linked glycosylation (HP:0012347)1.78945636
106Entropion (HP:0000621)1.78801339
107Flat occiput (HP:0005469)1.78017289
108Fetal akinesia sequence (HP:0001989)1.77816781
109Hypercholesterolemia (HP:0003124)1.77434498
110Easy fatigability (HP:0003388)1.77160201
111Turricephaly (HP:0000262)1.76049982
112Achilles tendon contracture (HP:0001771)1.75740897
113Global brain atrophy (HP:0002283)1.75523778
114Abnormality of the heme biosynthetic pathway (HP:0010472)1.75033546
115Decreased central vision (HP:0007663)1.74783234
116Malnutrition (HP:0004395)1.73536465
117Hypobetalipoproteinemia (HP:0003563)1.72665885
118Pallor (HP:0000980)1.71413787
119Increased muscle lipid content (HP:0009058)1.71211558
120Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.70071972
121Reduced antithrombin III activity (HP:0001976)1.69270219
122Cerebellar dysplasia (HP:0007033)1.68368027
123Amyotrophic lateral sclerosis (HP:0007354)1.67513196
124Personality changes (HP:0000751)1.64925971
125Constricted visual fields (HP:0001133)1.63536457
126Abnormality of monocarboxylic acid metabolism (HP:0010996)1.62960642
127Macrocytic anemia (HP:0001972)1.61722006
128Hepatocellular necrosis (HP:0001404)1.59984307
129Lactic acidosis (HP:0003128)1.58949819
130Hypoplasia of the capital femoral epiphysis (HP:0003090)1.58573829
131Spastic tetraparesis (HP:0001285)1.57253301
132Fatigue (HP:0012378)1.56053544
133Loss of speech (HP:0002371)1.54085134
134Emotional lability (HP:0000712)1.53374353
135Unsteady gait (HP:0002317)1.52956560
136Microretrognathia (HP:0000308)1.52119783
137Xanthomatosis (HP:0000991)1.51923682
138Progressive microcephaly (HP:0000253)1.51360331
139Abnormality of the anterior horn cell (HP:0006802)1.51312529
140Degeneration of anterior horn cells (HP:0002398)1.51312529
141Hepatic necrosis (HP:0002605)1.51233334
142Pancytopenia (HP:0001876)1.51052097
143Increased serum lactate (HP:0002151)1.50490454
144Abnormality of reticulocytes (HP:0004312)1.50332532
145Aplastic anemia (HP:0001915)1.49757899
146Multiple enchondromatosis (HP:0005701)1.49217081
147Dicarboxylic aciduria (HP:0003215)1.46588594
148Abnormality of dicarboxylic acid metabolism (HP:0010995)1.46588594
149Hypertriglyceridemia (HP:0002155)1.45410537
150Abnormal mitochondria in muscle tissue (HP:0008316)1.44134755
151Increased intramyocellular lipid droplets (HP:0012240)1.43687730
152Ketosis (HP:0001946)1.43600547
153Thrombocytosis (HP:0001894)1.42900091
154Abnormality of midbrain morphology (HP:0002418)1.40527636
155Molar tooth sign on MRI (HP:0002419)1.40527636
156Abnormality of pyrimidine metabolism (HP:0004353)1.40385633
157Hemorrhage of the eye (HP:0011885)1.40309640
158Tubular atrophy (HP:0000092)1.40051712
159Neurodegeneration (HP:0002180)1.39883525
160Mitochondrial inheritance (HP:0001427)1.39489429
161Acute necrotizing encephalopathy (HP:0006965)1.38546549
162Hyperammonemia (HP:0001987)1.38480636
163Bile duct proliferation (HP:0001408)1.36972723
164Abnormal biliary tract physiology (HP:0012439)1.36972723
165Type I transferrin isoform profile (HP:0003642)1.35969387

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK16.13147642
2PDK45.51093800
3PDK35.51093800
4ICK3.53868962
5PRKD33.52879348
6VRK23.16581539
7PDK23.16058449
8TESK22.96666307
9BUB12.60454506
10IRAK32.38820491
11NME22.38306755
12SMG12.37367666
13NEK22.33503939
14DYRK32.05786385
15WEE11.99636049
16BCKDK1.91682810
17EPHA21.82796769
18STK161.74520599
19TAOK21.72884033
20ERN11.65142553
21MAP3K101.54602495
22MAP4K11.52902280
23BRSK21.45838413
24SIK11.41790214
25ABL21.38210868
26KDR1.34217575
27DYRK1B1.25599115
28ARAF1.23029964
29EEF2K1.21370925
30MAP3K111.20140828
31PTK2B1.20053692
32ZAP701.17288407
33PASK1.15262341
34BRAF1.14661133
35STK381.14478526
36PIM21.14436216
37TRIB31.09612391
38GRK61.08620997
39BRSK11.06366120
40EIF2AK11.02015831
41PRKD21.00323399
42PRPF4B1.00165445
43WNK40.99412811
44MAPK150.99190813
45RPS6KA40.98379740
46PDK10.97824817
47MAP2K20.94221875
48SCYL20.92448184
49PRKCI0.90305658
50ZAK0.89726867
51CDC70.87797939
52STK100.86952455
53MAP4K20.85368252
54RPS6KB20.84492383
55MAPKAPK30.84066071
56AURKA0.83567091
57EIF2AK30.83164209
58CAMK1D0.82870227
59RPS6KA50.80273375
60TLK10.78984821
61MAP3K30.78333046
62RPS6KC10.78271927
63RPS6KL10.78271927
64IRAK20.74515756
65CCNB10.72543827
66TBK10.71491963
67PAK40.71257650
68PAK10.70411144
69MST1R0.69834614
70IKBKB0.68312655
71TAOK10.67150781
72CDK190.65995138
73PDPK10.65812941
74FLT30.64554144
75LIMK10.63953217
76SRPK10.63040740
77RPS6KA60.63033905
78PLK10.62942323
79RAF10.61128753
80MAP3K80.59207805
81NME10.57794182
82RPS6KA20.55375267
83IRAK10.53552738
84TTK0.52957231
85LRRK20.52559720
86CDK60.52405662
87BTK0.51873112
88MAP2K60.50435445
89CHEK20.49916619
90HIPK20.49638439
91MARK30.49113198
92TNK20.48310758
93MTOR0.44734010
94KIT0.44122987
95BLK0.43446887
96ACVR1B0.43138141
97MAP3K50.42814380
98MAP3K10.42806120
99CAMKK20.42637011
100NLK0.42008666
101CDK40.41562806
102ATR0.41321794
103PBK0.40953505
104CAMK2G0.40827295
105AURKB0.40325466
106PIM10.40307833
107MAP2K30.39466942
108SIK20.38335895
109CDK70.37775408
110VRK10.35942618
111PKN20.35453962
112CSNK1G30.35163228
113CDK80.35158945
114CAMKK10.35104751
115TYK20.32580080
116DAPK30.32361855
117CSF1R0.31650197
118CSNK2A10.30972279
119CDK20.30812292
120CDK150.30644860
121SYK0.29962717
122RIPK40.29418013
123TEC0.28665081
124CDK140.28085262
125CSNK2A20.27726995
126MAPKAPK20.27516742
127RPS6KA10.27251790
128TYRO30.26984783
129MAP3K90.26769784
130MAPK110.26574836
131PNCK0.26187380
132CHEK10.25095048
133DAPK10.24673355
134PRKG20.24075996
135CDK11A0.23373361
136ILK0.23354881
137AKT20.22883967
138PLK40.21031853
139MUSK0.20868499
140STK390.20792054
141KSR20.20786471

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.89502203
2DNA replication_Homo sapiens_hsa030303.11780897
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.00705100
4Sulfur relay system_Homo sapiens_hsa041222.91246752
5Proteasome_Homo sapiens_hsa030502.63031425
6Ribosome_Homo sapiens_hsa030102.55641242
7Pyruvate metabolism_Homo sapiens_hsa006202.49447928
8Vitamin B6 metabolism_Homo sapiens_hsa007502.42251502
9Selenocompound metabolism_Homo sapiens_hsa004502.42037829
10Pentose phosphate pathway_Homo sapiens_hsa000302.33667677
11Pyrimidine metabolism_Homo sapiens_hsa002402.26757106
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.10928571
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.00637727
14Linoleic acid metabolism_Homo sapiens_hsa005911.89712679
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.87903825
16Cysteine and methionine metabolism_Homo sapiens_hsa002701.82806484
17Base excision repair_Homo sapiens_hsa034101.81553062
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.81522857
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.81063629
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.79048182
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.74051164
22Carbon metabolism_Homo sapiens_hsa012001.72905825
23RNA transport_Homo sapiens_hsa030131.66870668
24Mismatch repair_Homo sapiens_hsa034301.66792436
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.66451651
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.64864690
27Fructose and mannose metabolism_Homo sapiens_hsa000511.64467650
28Huntingtons disease_Homo sapiens_hsa050161.58767624
29RNA polymerase_Homo sapiens_hsa030201.58422747
30Fat digestion and absorption_Homo sapiens_hsa049751.57457943
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.57341883
32Basal transcription factors_Homo sapiens_hsa030221.48845595
33Spliceosome_Homo sapiens_hsa030401.47742456
34Biosynthesis of amino acids_Homo sapiens_hsa012301.47402849
35Fatty acid biosynthesis_Homo sapiens_hsa000611.45682776
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.44758594
37Propanoate metabolism_Homo sapiens_hsa006401.43295031
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.42132915
39Oxidative phosphorylation_Homo sapiens_hsa001901.39506431
40Phenylalanine metabolism_Homo sapiens_hsa003601.37612951
41Parkinsons disease_Homo sapiens_hsa050121.37259117
42Antigen processing and presentation_Homo sapiens_hsa046121.36682780
43Purine metabolism_Homo sapiens_hsa002301.36416593
44Fatty acid degradation_Homo sapiens_hsa000711.33227421
45Glutathione metabolism_Homo sapiens_hsa004801.31245209
46Homologous recombination_Homo sapiens_hsa034401.31053915
47Glucagon signaling pathway_Homo sapiens_hsa049221.30995507
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.21626003
49Carbohydrate digestion and absorption_Homo sapiens_hsa049731.11288978
50Drug metabolism - other enzymes_Homo sapiens_hsa009831.10615210
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10605027
52Folate biosynthesis_Homo sapiens_hsa007901.08849139
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07175287
54Lysosome_Homo sapiens_hsa041421.06307120
55One carbon pool by folate_Homo sapiens_hsa006701.05945633
56Pentose and glucuronate interconversions_Homo sapiens_hsa000401.04804538
57Glycerolipid metabolism_Homo sapiens_hsa005611.04280675
58Chemical carcinogenesis_Homo sapiens_hsa052041.04247842
59Cyanoamino acid metabolism_Homo sapiens_hsa004601.03822716
60N-Glycan biosynthesis_Homo sapiens_hsa005101.02263568
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02240872
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00609835
63Nucleotide excision repair_Homo sapiens_hsa034200.99889337
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98836198
65Glycerophospholipid metabolism_Homo sapiens_hsa005640.96735145
66PPAR signaling pathway_Homo sapiens_hsa033200.96181133
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.94004175
68Bladder cancer_Homo sapiens_hsa052190.92061593
69Sulfur metabolism_Homo sapiens_hsa009200.91995834
70Galactose metabolism_Homo sapiens_hsa000520.90507459
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90329189
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.87669916
73Fanconi anemia pathway_Homo sapiens_hsa034600.84769335
74Systemic lupus erythematosus_Homo sapiens_hsa053220.84234171
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83770526
76Tyrosine metabolism_Homo sapiens_hsa003500.82733633
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82664061
78Peroxisome_Homo sapiens_hsa041460.82463642
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.81025129
80Cardiac muscle contraction_Homo sapiens_hsa042600.81017670
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80395425
82Sphingolipid metabolism_Homo sapiens_hsa006000.80170756
83Metabolic pathways_Homo sapiens_hsa011000.76901590
84Cell cycle_Homo sapiens_hsa041100.76693807
85Alzheimers disease_Homo sapiens_hsa050100.76175920
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75453395
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74086225
88Acute myeloid leukemia_Homo sapiens_hsa052210.73173393
89Oocyte meiosis_Homo sapiens_hsa041140.71112386
90Fatty acid metabolism_Homo sapiens_hsa012120.63988723
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.58667307
92RNA degradation_Homo sapiens_hsa030180.57779244
93Other glycan degradation_Homo sapiens_hsa005110.56726374
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55359876
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55085519
96Primary immunodeficiency_Homo sapiens_hsa053400.54219324
97Fatty acid elongation_Homo sapiens_hsa000620.53894304
98Apoptosis_Homo sapiens_hsa042100.53729768
99Legionellosis_Homo sapiens_hsa051340.50913387
100Herpes simplex infection_Homo sapiens_hsa051680.49127690
101mRNA surveillance pathway_Homo sapiens_hsa030150.48114107
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44914526
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44150156
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43332429
105Arachidonic acid metabolism_Homo sapiens_hsa005900.43207356
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42973106
107Protein export_Homo sapiens_hsa030600.42835846
108Renin-angiotensin system_Homo sapiens_hsa046140.42015386
109Shigellosis_Homo sapiens_hsa051310.41301940
110Vitamin digestion and absorption_Homo sapiens_hsa049770.39494588
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.39169392
112Non-homologous end-joining_Homo sapiens_hsa034500.38765359
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38603370
114ABC transporters_Homo sapiens_hsa020100.38323206
115Epstein-Barr virus infection_Homo sapiens_hsa051690.37873318
116p53 signaling pathway_Homo sapiens_hsa041150.37865561
117Caffeine metabolism_Homo sapiens_hsa002320.37364215
118Vibrio cholerae infection_Homo sapiens_hsa051100.35755077
119Bile secretion_Homo sapiens_hsa049760.34902299
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34565160
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.34557212
122Mineral absorption_Homo sapiens_hsa049780.29838165
123mTOR signaling pathway_Homo sapiens_hsa041500.27831980
124Hepatitis C_Homo sapiens_hsa051600.27033619
125Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25808947
126Endocytosis_Homo sapiens_hsa041440.25702308
127Steroid biosynthesis_Homo sapiens_hsa001000.24396728
128Arginine and proline metabolism_Homo sapiens_hsa003300.24088170
129Viral carcinogenesis_Homo sapiens_hsa052030.23178637
130Alcoholism_Homo sapiens_hsa050340.22329365
131HTLV-I infection_Homo sapiens_hsa051660.21839745
132Hedgehog signaling pathway_Homo sapiens_hsa043400.20030274
133Arginine biosynthesis_Homo sapiens_hsa002200.19476014

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