ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	termination of RNA polymerase III transcription (GO:0006386)	5.40941953
2	transcription elongation from RNA polymerase III promoter (GO:0006385)	5.40941953
3	proteasome assembly (GO:0043248)	5.17362478
4	purine nucleobase biosynthetic process (GO:0009113)	4.82644688
5	7-methylguanosine mRNA capping (GO:0006370)	4.81143159
6	rRNA modification (GO:0000154)	4.80367398
7	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.75858512
8	ATP synthesis coupled proton transport (GO:0015986)	4.75858512
9	RNA capping (GO:0036260)	4.74557768
10	7-methylguanosine RNA capping (GO:0009452)	4.74557768
11	mitotic metaphase plate congression (GO:0007080)	4.70088580
12	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.55840429
13	DNA deamination (GO:0045006)	4.49775262
14	transcription elongation from RNA polymerase I promoter (GO:0006362)	4.49044667
15	termination of RNA polymerase I transcription (GO:0006363)	4.40977950
16	protein complex biogenesis (GO:0070271)	4.36990051
17	nucleobase biosynthetic process (GO:0046112)	4.35518213
18	ribosome biogenesis (GO:0042254)	4.32655838
19	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.23937450
20	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.23937450
21	NADH dehydrogenase complex assembly (GO:0010257)	4.23937450
22	ribosome assembly (GO:0042255)	4.22145718
23	transcription from RNA polymerase I promoter (GO:0006360)	4.21544706
24	mitochondrial respiratory chain complex assembly (GO:0033108)	4.12434510
25	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	4.12120554
26	DNA replication checkpoint (GO:0000076)	4.10847728
27	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	4.10124845
28	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	4.07994377
29	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	4.05780674
30	respiratory electron transport chain (GO:0022904)	3.96646103
31	respiratory chain complex IV assembly (GO:0008535)	3.94961337
32	electron transport chain (GO:0022900)	3.92447585
33	ribonucleoprotein complex biogenesis (GO:0022613)	3.88675572
34	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.85856960
35	transcription initiation from RNA polymerase I promoter (GO:0006361)	3.84580822
36	spliceosomal snRNP assembly (GO:0000387)	3.84058303
37	maturation of 5.8S rRNA (GO:0000460)	3.80707342
38	rRNA methylation (GO:0031167)	3.80507089
39	maturation of SSU-rRNA (GO:0030490)	3.79344906
40	behavioral response to nicotine (GO:0035095)	3.77212372
41	chaperone-mediated protein transport (GO:0072321)	3.72983201
42	CENP-A containing nucleosome assembly (GO:0034080)	3.72583907
43	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.70864975
44	negative regulation of ligase activity (GO:0051352)	3.70864975
45	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.68557613
46	transcription elongation from RNA polymerase II promoter (GO:0006368)	3.67129595
47	metaphase plate congression (GO:0051310)	3.65421649
48	rRNA processing (GO:0006364)	3.65273779
49	DNA-templated transcription, elongation (GO:0006354)	3.63644432
50	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.60195995
51	protein neddylation (GO:0045116)	3.57682815
52	rRNA metabolic process (GO:0016072)	3.55645789
53	ribosomal large subunit biogenesis (GO:0042273)	3.55200387
54	cytochrome complex assembly (GO:0017004)	3.54800488
55	protein K6-linked ubiquitination (GO:0085020)	3.54165529
56	regulation of cellular amino acid metabolic process (GO:0006521)	3.53019612
57	positive regulation of ligase activity (GO:0051351)	3.52524331
58	pseudouridine synthesis (GO:0001522)	3.52405403
59	chromatin remodeling at centromere (GO:0031055)	3.52186257
60	guanosine-containing compound biosynthetic process (GO:1901070)	3.48107866
61	transcription-coupled nucleotide-excision repair (GO:0006283)	3.46494707
62	cellular component biogenesis (GO:0044085)	3.38079788
63	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.37946243
64	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.37946243
65	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.37946243
66	positive regulation of viral transcription (GO:0050434)	3.37205719
67	protein targeting to mitochondrion (GO:0006626)	3.36649442
68	ribosomal small subunit assembly (GO:0000028)	3.36360247
69	L-methionine salvage (GO:0071267)	3.35842996
70	L-methionine biosynthetic process (GO:0071265)	3.35842996
71	amino acid salvage (GO:0043102)	3.35842996
72	regulation of mitochondrial translation (GO:0070129)	3.35397583
73	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.34460435
74	kinetochore assembly (GO:0051382)	3.34029174
75	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.31701174
76	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.31701174
77	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.31358294
78	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.31358294
79	microtubule depolymerization (GO:0007019)	3.28843916
80	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.28637413
81	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.28637413
82	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.27975653
83	establishment of protein localization to mitochondrion (GO:0072655)	3.27580087
84	regulation of spindle organization (GO:0090224)	3.26279068
85	positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)	3.25946987
86	blastocyst development (GO:0001824)	3.25832214
87	regulation of ubiquitin-protein transferase activity (GO:0051438)	3.23432608
88	DNA replication initiation (GO:0006270)	3.23193321
89	translational termination (GO:0006415)	3.21684685
90	cullin deneddylation (GO:0010388)	3.21641450
91	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.20562382
92	ribosomal small subunit biogenesis (GO:0042274)	3.19099276
93	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.19019367
94	histone exchange (GO:0043486)	3.17590879
95	viral transcription (GO:0019083)	3.16570140
96	spliceosomal complex assembly (GO:0000245)	3.16341502
97	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.16116096
98	protein deneddylation (GO:0000338)	3.13056148
99	regulation of ligase activity (GO:0051340)	3.11947982
100	transcription from RNA polymerase III promoter (GO:0006383)	3.10397575
101	GMP metabolic process (GO:0046037)	3.08727545
102	protein-cofactor linkage (GO:0018065)	3.07050922
103	cell cycle G1/S phase transition (GO:0044843)	3.05784763
104	G1/S transition of mitotic cell cycle (GO:0000082)	3.05784763
105	DNA replication-independent nucleosome assembly (GO:0006336)	3.04871786
106	DNA replication-independent nucleosome organization (GO:0034724)	3.04871786
107	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.03822823
108	DNA-templated transcription, termination (GO:0006353)	3.03655646
109	protein localization to mitochondrion (GO:0070585)	3.03078982
110	spindle checkpoint (GO:0031577)	3.03056351
111	establishment of chromosome localization (GO:0051303)	3.00950205
112	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.00708957
113	peptidyl-histidine modification (GO:0018202)	2.98965966
114	regulation of double-strand break repair via homologous recombination (GO:0010569)	2.98957307
115	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.98426538
116	cotranslational protein targeting to membrane (GO:0006613)	2.98063536
117	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.98058877
118	regulation of mitotic spindle checkpoint (GO:1903504)	2.98058877
119	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.97913115
120	kinetochore organization (GO:0051383)	2.97795281
121	DNA-dependent DNA replication (GO:0006261)	2.97769590
122	replication fork processing (GO:0031297)	2.96918947
123	water-soluble vitamin biosynthetic process (GO:0042364)	2.93751792
124	GTP biosynthetic process (GO:0006183)	2.93683852
125	RNA methylation (GO:0001510)	2.90326881
126	protein targeting to ER (GO:0045047)	2.89173627
127	hydrogen ion transmembrane transport (GO:1902600)	2.84587019
128	DNA double-strand break processing (GO:0000729)	2.84375575
129	ATP biosynthetic process (GO:0006754)	2.84372008
130	nonmotile primary cilium assembly (GO:0035058)	2.80537246
131	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.79886611
132	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.76959214
133	intracellular protein transmembrane import (GO:0044743)	2.73842944
134	protein localization to endoplasmic reticulum (GO:0070972)	2.72833243
135	translational elongation (GO:0006414)	2.72793487
136	platelet dense granule organization (GO:0060155)	2.71709169
137	DNA damage response, detection of DNA damage (GO:0042769)	2.71637476
138	sequestering of actin monomers (GO:0042989)	2.71362116
139	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.70402741
140	proton transport (GO:0015992)	2.69265528
141	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.67574405
142	regulation of cilium movement (GO:0003352)	2.66744552
143	translation (GO:0006412)	2.65900497
144	tRNA processing (GO:0008033)	2.63326593
145	hydrogen transport (GO:0006818)	2.62726273
146	recombinational repair (GO:0000725)	2.60896413
147	centriole replication (GO:0007099)	2.60576105
148	mannosylation (GO:0097502)	2.58704711
149	histone mRNA metabolic process (GO:0008334)	2.57905172
150	double-strand break repair via homologous recombination (GO:0000724)	2.57411743
151	indolalkylamine metabolic process (GO:0006586)	2.53549084
152	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.52797093
153	inner mitochondrial membrane organization (GO:0007007)	2.50275341
154	translational initiation (GO:0006413)	2.50073753
155	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.49475928
156	piRNA metabolic process (GO:0034587)	2.48842866
157	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.48543880
158	kynurenine metabolic process (GO:0070189)	2.46576076
159	anterograde synaptic vesicle transport (GO:0048490)	2.45989845
160	cellular protein complex disassembly (GO:0043624)	2.44062441
161	resolution of meiotic recombination intermediates (GO:0000712)	2.43117728
162	epithelial cilium movement (GO:0003351)	2.41537213

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.43933887
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.90242062
3	E2F7_22180533_ChIP-Seq_HELA_Human	4.45056189
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.19844139
5	* JARID1A_20064375_ChIP-Seq_MESCs_Mouse	4.07724176
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.92804399
7	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.82513688
8	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.75177081
9	* ETS1_20019798_ChIP-Seq_JURKAT_Human	3.68905546
10	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.56703211
11	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.01723828
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.98000018
13	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.91289891
14	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.84987973
15	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.82851567
16	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.79627002
17	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.75381694
18	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.75040190
19	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.68489744
20	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.66248211
21	* VDR_23849224_ChIP-Seq_CD4+_Human	2.66172800
22	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.61611443
23	* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.45861237
24	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.40575632
25	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.29377032
26	EZH2_22144423_ChIP-Seq_EOC_Human	2.28718494
27	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.20332501
28	EWS_26573619_Chip-Seq_HEK293_Human	2.14392481
29	* YY1_21170310_ChIP-Seq_MESCs_Mouse	2.13605297
30	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.13137416
31	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.08688255
32	DCP1A_22483619_ChIP-Seq_HELA_Human	2.06776468
33	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.03818117
34	GBX2_23144817_ChIP-Seq_PC3_Human	2.01853712
35	* FOXP3_21729870_ChIP-Seq_TREG_Human	2.01348283
36	XRN2_22483619_ChIP-Seq_HELA_Human	2.00591656
37	IGF1R_20145208_ChIP-Seq_DFB_Human	1.99841167
38	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.99715484
39	ELK1_19687146_ChIP-ChIP_HELA_Human	1.99098863
40	* E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.98417534
41	GABP_19822575_ChIP-Seq_HepG2_Human	1.93535358
42	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.89890243
43	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.88977570
44	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.88859996
45	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.85070236
46	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.83564388
47	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.80396735
48	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.80167955
49	TTF2_22483619_ChIP-Seq_HELA_Human	1.79261097
50	P300_19829295_ChIP-Seq_ESCs_Human	1.76949889
51	* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.72082219
52	* NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.70577553
53	TAF15_26573619_Chip-Seq_HEK293_Human	1.70164470
54	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.70036127
55	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.66690884
56	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.63492176
57	* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.62237151
58	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.61151312
59	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.51196762
60	TP53_22573176_ChIP-Seq_HFKS_Human	1.48206416
61	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.46205425
62	AR_21909140_ChIP-Seq_LNCAP_Human	1.45997757
63	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.44175717
64	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.44161751
65	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.39028186
66	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.36088621
67	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.36029172
68	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.35544337
69	* ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.34837516
70	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.33574460
71	* HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.32786044
72	* KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.31834146
73	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.31328262
74	ER_23166858_ChIP-Seq_MCF-7_Human	1.28740379
75	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.28437112
76	MYC_18940864_ChIP-ChIP_HL60_Human	1.24669966
77	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.22893205
78	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.22742802
79	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.22251977
80	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.21360196
81	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.16296678
82	CBP_20019798_ChIP-Seq_JUKART_Human	1.16296678
83	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.14723992
84	RNF2_27304074_Chip-Seq_NSC_Mouse	1.14293797
85	SOX2_19829295_ChIP-Seq_ESCs_Human	1.13614745
86	NANOG_19829295_ChIP-Seq_ESCs_Human	1.13614745
87	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.11429697
88	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.11057109
89	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.10794599
90	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.09629003
91	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.03192698
92	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.03192698
93	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.02902651
94	KDM5A_27292631_Chip-Seq_BREAST_Human	1.02564324
95	IRF1_19129219_ChIP-ChIP_H3396_Human	1.01778826
96	BCAT_22108803_ChIP-Seq_LS180_Human	1.01213792
97	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.99574096
98	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.97674653
99	NCOR_22424771_ChIP-Seq_293T_Human	0.96928588
100	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.96596448
101	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.96503867
102	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.95477801
103	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.95428026
104	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.95264473
105	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.95264473
106	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.95132459
107	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.94951277
108	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.94727924
109	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.94328836
110	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.93430840
111	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.92782197
112	* REST_21632747_ChIP-Seq_MESCs_Mouse	0.92686612
113	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.92259278
114	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.91927987
115	* TCF4_22108803_ChIP-Seq_LS180_Human	0.91716869
116	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.91705426
117	AR_25329375_ChIP-Seq_VCAP_Human	0.91090789
118	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.90954691
119	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.90671731
120	SMAD4_21799915_ChIP-Seq_A2780_Human	0.90532044
121	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.90452086
122	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.89793883
123	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.86423723
124	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.85429347
125	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.84148892
126	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.84072869
127	* SOX17_20123909_ChIP-Seq_XEN_Mouse	0.82630979
128	CIITA_25753668_ChIP-Seq_RAJI_Human	0.79152409
129	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.78543721
130	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.77362683
131	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	0.75888892
132	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.75680695
133	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.75573969
134	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.75436476
135	VDR_22108803_ChIP-Seq_LS180_Human	0.72613694
136	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.71164120
137	* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.70508726
138	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.70330601
139	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.69349309
140	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.67151253
141	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.66162508
142	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.65926994
143	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.64598186
144	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	0.64320266
145	FUS_26573619_Chip-Seq_HEK293_Human	0.64061181
146	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.63677978
147	TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse	0.63466453
148	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.62111924
149	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.62016921

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003693_abnormal_embryo_hatching	5.36582064
2	MP0003111_abnormal_nucleus_morphology	4.01228455
3	MP0003718_maternal_effect	3.86005893
4	MP0008058_abnormal_DNA_repair	3.62033206
5	MP0008057_abnormal_DNA_replication	3.53093421
6	MP0004957_abnormal_blastocyst_morpholog	3.49230300
7	MP0010094_abnormal_chromosome_stability	3.42416438
8	MP0003077_abnormal_cell_cycle	3.15679771
9	MP0008877_abnormal_DNA_methylation	2.84395190
10	MP0006292_abnormal_olfactory_placode	2.83174419
11	MP0008932_abnormal_embryonic_tissue	2.57854585
12	MP0008260_abnormal_autophagy	2.53279547
13	MP0003786_premature_aging	2.44054082
14	MP0001529_abnormal_vocalization	2.31487585
15	MP0002102_abnormal_ear_morphology	2.14210997
16	MP0008007_abnormal_cellular_replicative	2.11389286
17	MP0005551_abnormal_eye_electrophysiolog	2.10773445
18	MP0001188_hyperpigmentation	2.04730333
19	MP0003123_paternal_imprinting	2.02532314
20	MP0001986_abnormal_taste_sensitivity	1.96035608
21	MP0006072_abnormal_retinal_apoptosis	1.92415777
22	MP0003136_yellow_coat_color	1.85607451
23	MP0003315_abnormal_perineum_morphology	1.85160681
24	MP0001984_abnormal_olfaction	1.73596243
25	MP0003787_abnormal_imprinting	1.73298262
26	MP0001905_abnormal_dopamine_level	1.71041800
27	MP0002163_abnormal_gland_morphology	1.61929854
28	MP0005253_abnormal_eye_physiology	1.57659641
29	MP0003880_abnormal_central_pattern	1.54882183
30	MP0002132_abnormal_respiratory_system	1.54355421
31	MP0002210_abnormal_sex_determination	1.54121353
32	MP0009745_abnormal_behavioral_response	1.53885872
33	MP0009379_abnormal_foot_pigmentation	1.52744689
34	MP0003195_calcinosis	1.52151789
35	MP0005646_abnormal_pituitary_gland	1.48725497
36	MP0002837_dystrophic_cardiac_calcinosis	1.48071392
37	MP0003938_abnormal_ear_development	1.45389700
38	MP0000631_abnormal_neuroendocrine_gland	1.44274526
39	MP0001929_abnormal_gametogenesis	1.40053801
40	MP0002160_abnormal_reproductive_system	1.39526173
41	MP0002653_abnormal_ependyma_morphology	1.39148576
42	MP0002638_abnormal_pupillary_reflex	1.36404793
43	MP0002277_abnormal_respiratory_mucosa	1.34379852
44	MP0001730_embryonic_growth_arrest	1.33682008
45	MP0005645_abnormal_hypothalamus_physiol	1.32169092
46	MP0009333_abnormal_splenocyte_physiolog	1.31260583
47	MP0001293_anophthalmia	1.30826610
48	MP0001145_abnormal_male_reproductive	1.28637653
49	MP0002234_abnormal_pharynx_morphology	1.28394382
50	MP0003011_delayed_dark_adaptation	1.27047879
51	MP0008872_abnormal_physiological_respon	1.26593208
52	MP0005084_abnormal_gallbladder_morpholo	1.24243528
53	MP0005171_absent_coat_pigmentation	1.24238974
54	MP0001661_extended_life_span	1.21859525
55	MP0003890_abnormal_embryonic-extraembry	1.20698881
56	MP0005389_reproductive_system_phenotype	1.20128782
57	MP0000653_abnormal_sex_gland	1.19056364
58	MP0000350_abnormal_cell_proliferation	1.18935705
59	MP0005395_other_phenotype	1.17540471
60	MP0003941_abnormal_skin_development	1.15572264
61	MP0006035_abnormal_mitochondrial_morpho	1.15410916
62	MP0004133_heterotaxia	1.14668926
63	MP0004145_abnormal_muscle_electrophysio	1.14432221
64	MP0005377_hearing/vestibular/ear_phenot	1.11319022
65	MP0003878_abnormal_ear_physiology	1.11319022
66	MP0003698_abnormal_male_reproductive	1.10646951
67	MP0002396_abnormal_hematopoietic_system	1.10385939
68	MP0001501_abnormal_sleep_pattern	1.10013299
69	MP0000569_abnormal_digit_pigmentation	1.09412735
70	MP0003806_abnormal_nucleotide_metabolis	1.08417310
71	MP0005410_abnormal_fertilization	1.05022028
72	MP0001542_abnormal_bone_strength	1.03417062
73	MP0003879_abnormal_hair_cell	1.02647290
74	MP0003119_abnormal_digestive_system	1.02343147
75	MP0002557_abnormal_social/conspecific_i	1.02288848
76	MP0000778_abnormal_nervous_system	1.01602779
77	MP0006276_abnormal_autonomic_nervous	1.01404460
78	MP0006036_abnormal_mitochondrial_physio	1.01217509
79	MP0000372_irregular_coat_pigmentation	1.00726243
80	MP0000427_abnormal_hair_cycle	1.00658197
81	MP0001324_abnormal_eye_pigmentation	1.00558591
82	MP0005174_abnormal_tail_pigmentation	0.99867389
83	MP0005379_endocrine/exocrine_gland_phen	0.99738097
84	MP0002067_abnormal_sensory_capabilities	0.99677781
85	MP0008875_abnormal_xenobiotic_pharmacok	0.99666183
86	MP0005195_abnormal_posterior_eye	0.99344183
87	MP0001485_abnormal_pinna_reflex	0.99096651
88	MP0003122_maternal_imprinting	0.98470013
89	MP0002064_seizures	0.98296040
90	MP0004147_increased_porphyrin_level	0.98114890
91	MP0005423_abnormal_somatic_nervous	0.97507633
92	MP0001440_abnormal_grooming_behavior	0.96835514
93	MP0003567_abnormal_fetal_cardiomyocyte	0.96608781
94	MP0000015_abnormal_ear_pigmentation	0.96248925
95	MP0004381_abnormal_hair_follicle	0.95849398
96	MP0002938_white_spotting	0.95105479
97	MP0002572_abnormal_emotion/affect_behav	0.94866860
98	MP0000049_abnormal_middle_ear	0.94844006
99	MP0008995_early_reproductive_senescence	0.94742310
100	MP0003646_muscle_fatigue	0.94501607
101	MP0002876_abnormal_thyroid_physiology	0.94422195
102	MP0004924_abnormal_behavior	0.93661535
103	MP0005386_behavior/neurological_phenoty	0.93661535
104	MP0010386_abnormal_urinary_bladder	0.93514201
105	MP0003121_genomic_imprinting	0.91783399
106	MP0010030_abnormal_orbit_morphology	0.91035874
107	MP0001727_abnormal_embryo_implantation	0.89579514
108	MP0009046_muscle_twitch	0.88861634
109	MP0002734_abnormal_mechanical_nocicepti	0.88548290
110	MP0001672_abnormal_embryogenesis/_devel	0.87607656
111	MP0005380_embryogenesis_phenotype	0.87607656
112	MP0001919_abnormal_reproductive_system	0.85223423
113	MP0001764_abnormal_homeostasis	0.84496048
114	MP0000313_abnormal_cell_death	0.84403759
115	MP0000566_synostosis	0.83606245
116	MP0002736_abnormal_nociception_after	0.83532669
117	MP0004142_abnormal_muscle_tone	0.81096906
118	MP0008789_abnormal_olfactory_epithelium	0.80739525
119	MP0001119_abnormal_female_reproductive	0.80697959
120	MP0005451_abnormal_body_composition	0.80022162
121	MP0004742_abnormal_vestibular_system	0.79616732
122	MP0002080_prenatal_lethality	0.79114569
123	MP0002735_abnormal_chemical_nociception	0.78892721
124	MP0005408_hypopigmentation	0.78548847
125	MP0003186_abnormal_redox_activity	0.78378867
126	MP0009697_abnormal_copulation	0.77229005
127	MP0001697_abnormal_embryo_size	0.76700448
128	MP0002161_abnormal_fertility/fecundity	0.76651003
129	MP0001963_abnormal_hearing_physiology	0.74971090
130	MP0002272_abnormal_nervous_system	0.73989882
131	MP0002095_abnormal_skin_pigmentation	0.72752042
132	MP0003937_abnormal_limbs/digits/tail_de	0.72034894
133	MP0000026_abnormal_inner_ear	0.71310686
134	MP0005409_darkened_coat_color	0.70291598
135	MP0001968_abnormal_touch/_nociception	0.70262441
136	MP0005075_abnormal_melanosome_morpholog	0.69574527
137	MP0002751_abnormal_autonomic_nervous	0.68073160
138	MP0002085_abnormal_embryonic_tissue	0.67922565
139	MP0001486_abnormal_startle_reflex	0.67385925
140	MP0000358_abnormal_cell_content/	0.66732605
141	MP0002752_abnormal_somatic_nervous	0.61912621
142	MP0005394_taste/olfaction_phenotype	0.60023377
143	MP0005499_abnormal_olfactory_system	0.60023377

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Birth length less than 3rd percentile (HP:0003561)	5.18754774
2	Breast hypoplasia (HP:0003187)	4.63217078
3	Cerebral hypomyelination (HP:0006808)	4.37791109
4	Carpal bone hypoplasia (HP:0001498)	3.75600783
5	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.66714978
6	Chromsome breakage (HP:0040012)	3.34218463
7	Abnormality of midbrain morphology (HP:0002418)	3.32459556
8	Molar tooth sign on MRI (HP:0002419)	3.32459556
9	Impulsivity (HP:0100710)	3.25118116
10	3-Methylglutaconic aciduria (HP:0003535)	3.23932898
11	Rough bone trabeculation (HP:0100670)	3.21673487
12	Patellar aplasia (HP:0006443)	3.09618445
13	Abnormality of the preputium (HP:0100587)	3.03915283
14	True hermaphroditism (HP:0010459)	3.02853976
15	Acute necrotizing encephalopathy (HP:0006965)	3.01863313
16	Aplasia/Hypoplasia of the patella (HP:0006498)	3.00361903
17	Medial flaring of the eyebrow (HP:0010747)	2.96123845
18	Mitochondrial inheritance (HP:0001427)	2.92154582
19	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.91251630
20	Meckel diverticulum (HP:0002245)	2.90166775
21	Abnormality of the labia minora (HP:0012880)	2.87651797
22	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.86699254
23	Congenital stationary night blindness (HP:0007642)	2.82463486
24	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.81522996
25	Increased hepatocellular lipid droplets (HP:0006565)	2.80724794
26	Absent radius (HP:0003974)	2.79748308
27	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.76780659
28	Pancreatic fibrosis (HP:0100732)	2.71968798
29	Abnormality of the ileum (HP:0001549)	2.70084890
30	CNS hypomyelination (HP:0003429)	2.69105615
31	Increased CSF lactate (HP:0002490)	2.67056912
32	Absent forearm bone (HP:0003953)	2.63551139
33	Aplasia involving forearm bones (HP:0009822)	2.63551139
34	Nephronophthisis (HP:0000090)	2.60210887
35	Delusions (HP:0000746)	2.60203050
36	Cerebral edema (HP:0002181)	2.59394901
37	Hepatocellular necrosis (HP:0001404)	2.58064787
38	Abnormality of cells of the erythroid lineage (HP:0012130)	2.55568746
39	Gait imbalance (HP:0002141)	2.53534806
40	Reticulocytopenia (HP:0001896)	2.53170879
41	Colon cancer (HP:0003003)	2.51286661
42	Abnormal mitochondria in muscle tissue (HP:0008316)	2.49756998
43	Abnormal trabecular bone morphology (HP:0100671)	2.48664268
44	Oral leukoplakia (HP:0002745)	2.48101289
45	Congenital primary aphakia (HP:0007707)	2.47806887
46	Optic disc pallor (HP:0000543)	2.46077162
47	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.43937492
48	Horseshoe kidney (HP:0000085)	2.42664384
49	Progressive macrocephaly (HP:0004481)	2.42566401
50	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.41414837
51	Increased serum lactate (HP:0002151)	2.41411642
52	Abnormal number of erythroid precursors (HP:0012131)	2.39816002
53	Secondary amenorrhea (HP:0000869)	2.39758215
54	Hyperalaninemia (HP:0003348)	2.39742680
55	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.39742680
56	Abnormality of alanine metabolism (HP:0010916)	2.39742680
57	Duplicated collecting system (HP:0000081)	2.39555719
58	Aplasia/hypoplasia of the uterus (HP:0008684)	2.36529894
59	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.31896852
60	Increased serum pyruvate (HP:0003542)	2.29575813
61	Abnormality of glycolysis (HP:0004366)	2.29575813
62	Abnormality of chromosome stability (HP:0003220)	2.29384553
63	Abnormal spermatogenesis (HP:0008669)	2.27756229
64	Pancreatic cysts (HP:0001737)	2.27724728
65	Renal Fanconi syndrome (HP:0001994)	2.27168571
66	Nephrogenic diabetes insipidus (HP:0009806)	2.27154252
67	Pendular nystagmus (HP:0012043)	2.26403163
68	Sclerocornea (HP:0000647)	2.25940699
69	Respiratory difficulties (HP:0002880)	2.25311323
70	Type II lissencephaly (HP:0007260)	2.24136590
71	Macrocytic anemia (HP:0001972)	2.22957584
72	Ureteral duplication (HP:0000073)	2.22954618
73	Premature graying of hair (HP:0002216)	2.22386737
74	Bone marrow hypocellularity (HP:0005528)	2.22010840
75	Irregular epiphyses (HP:0010582)	2.20946379
76	Lipid accumulation in hepatocytes (HP:0006561)	2.19292980
77	Acute encephalopathy (HP:0006846)	2.17971699
78	Abnormality of the renal cortex (HP:0011035)	2.17494102
79	Abnormality of the renal medulla (HP:0100957)	2.16951359
80	Genital tract atresia (HP:0001827)	2.16609467
81	Methylmalonic aciduria (HP:0012120)	2.15737388
82	Type 2 muscle fiber atrophy (HP:0003554)	2.15388133
83	Methylmalonic acidemia (HP:0002912)	2.14504432
84	Hypoplasia of the pons (HP:0012110)	2.10628251
85	Vaginal atresia (HP:0000148)	2.10539986
86	Triphalangeal thumb (HP:0001199)	2.09677980
87	Premature ovarian failure (HP:0008209)	2.09633687
88	Exertional dyspnea (HP:0002875)	2.08660494
89	Abnormality of the renal collecting system (HP:0004742)	2.08199955
90	Anencephaly (HP:0002323)	2.08002859
91	Absent thumb (HP:0009777)	2.07797285
92	Chronic hepatic failure (HP:0100626)	2.06940406
93	Small intestinal stenosis (HP:0012848)	2.05682812
94	Duodenal stenosis (HP:0100867)	2.05682812
95	Unsteady gait (HP:0002317)	2.04862914
96	Abnormality of the pons (HP:0007361)	2.04750882
97	Attenuation of retinal blood vessels (HP:0007843)	2.04515976
98	External ophthalmoplegia (HP:0000544)	2.04470825
99	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.04236379
100	Hyperglycinemia (HP:0002154)	2.04076464
101	Cleft eyelid (HP:0000625)	2.03081859
102	CNS demyelination (HP:0007305)	2.02432985
103	Increased intramyocellular lipid droplets (HP:0012240)	2.02314690
104	Abolished electroretinogram (ERG) (HP:0000550)	2.01991846
105	Hepatic necrosis (HP:0002605)	2.01460588
106	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.01031227
107	Optic nerve hypoplasia (HP:0000609)	1.99011435
108	Microvesicular hepatic steatosis (HP:0001414)	1.98643598
109	Sparse eyelashes (HP:0000653)	1.97653862
110	Leukodystrophy (HP:0002415)	1.97515622
111	Hypothermia (HP:0002045)	1.97189789
112	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.94506641
113	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.94356425
114	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.94356425
115	Respiratory failure (HP:0002878)	1.93893516
116	Facial cleft (HP:0002006)	1.93445495
117	Breast aplasia (HP:0100783)	1.93044085
118	Muscle fiber atrophy (HP:0100295)	1.92836724
119	Progressive muscle weakness (HP:0003323)	1.92588976
120	Degeneration of anterior horn cells (HP:0002398)	1.91196475
121	Abnormality of the anterior horn cell (HP:0006802)	1.91196475
122	Renal cortical cysts (HP:0000803)	1.90907792
123	Supernumerary spleens (HP:0009799)	1.89956690
124	Septo-optic dysplasia (HP:0100842)	1.88868666
125	Retinal dysplasia (HP:0007973)	1.88205676
126	Cystic liver disease (HP:0006706)	1.87653778
127	Progressive external ophthalmoplegia (HP:0000590)	1.87580262
128	Aplasia/Hypoplasia of the breasts (HP:0010311)	1.84898748
129	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.82850801
130	Concave nail (HP:0001598)	1.82821372
131	Lactic acidosis (HP:0003128)	1.82213199
132	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.82053991
133	Absent epiphyses (HP:0010577)	1.82053991
134	Congenital, generalized hypertrichosis (HP:0004540)	1.81988187
135	Exercise intolerance (HP:0003546)	1.81735520
136	Adrenal hypoplasia (HP:0000835)	1.80814514
137	Lissencephaly (HP:0001339)	1.79980025
138	Anophthalmia (HP:0000528)	1.79528208
139	Male pseudohermaphroditism (HP:0000037)	1.78179516
140	Lethargy (HP:0001254)	1.77300916
141	Abnormal respiratory epithelium morphology (HP:0012253)	1.76968839
142	Abnormal respiratory motile cilium morphology (HP:0005938)	1.76968839
143	Conical tooth (HP:0000698)	1.76329325
144	Preaxial hand polydactyly (HP:0001177)	1.75700568
145	Dysautonomia (HP:0002459)	1.75513990
146	Inability to walk (HP:0002540)	1.74826123
147	Broad-based gait (HP:0002136)	1.74809892
148	Postaxial foot polydactyly (HP:0001830)	1.74225936
149	Bile duct proliferation (HP:0001408)	1.73629434
150	Abnormal biliary tract physiology (HP:0012439)	1.73629434
151	Limb dystonia (HP:0002451)	1.73142268
152	Oligodactyly (hands) (HP:0001180)	1.72215705
153	Abnormality of renal resorption (HP:0011038)	1.71056705
154	Gaze-evoked nystagmus (HP:0000640)	1.70739511
155	Type I transferrin isoform profile (HP:0003642)	1.68990202
156	Bony spicule pigmentary retinopathy (HP:0007737)	1.67849817
157	Poor coordination (HP:0002370)	1.67696741
158	Postaxial hand polydactyly (HP:0001162)	1.67688356
159	Stenosis of the external auditory canal (HP:0000402)	1.67525225

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BUB1	5.19246752
2	STK16	3.86470986
3	FRK	3.72559818
4	WEE1	3.72047971
5	PLK4	3.28027313
6	EIF2AK1	3.14336044
7	SRPK1	3.04262419
8	NUAK1	2.67877097
9	VRK2	2.54899906
10	MAP4K2	2.50197382
11	BRSK2	2.38230959
12	AKT3	2.30357799
13	ZAK	2.27608438
14	TSSK6	2.26198890
15	EIF2AK3	2.24984709
16	NME2	2.10396869
17	PLK3	2.07128723
18	MKNK2	1.96588846
19	IRAK3	1.94480071
20	VRK1	1.91271055
21	PNCK	1.90869631
22	NME1	1.88868174
23	CCNB1	1.84651495
24	TRIM28	1.79186822
25	PLK1	1.71435013
26	CASK	1.70885725
27	MKNK1	1.65510447
28	TTK	1.65068676
29	MAP3K4	1.56724567
30	BRSK1	1.48701861
31	ARAF	1.41160556
32	WNK4	1.36952341
33	INSRR	1.35746316
34	PINK1	1.33658519
35	EIF2AK2	1.32377500
36	BRAF	1.30728244
37	NEK2	1.22764290
38	CHEK2	1.22619028
39	CDC7	1.20715506
40	TLK1	1.18047548
41	BCKDK	1.16320894
42	PIM2	1.14865936
43	EPHA2	1.11209866
44	DYRK2	1.09981800
45	PASK	1.09697620
46	AURKA	1.09623683
47	ACVR1B	1.07300656
48	AURKB	1.04419882
49	NEK6	1.03212182
50	DYRK3	0.99973556
51	STK38L	0.98947732
52	CDK3	0.98658197
53	TESK2	0.97491850
54	PBK	0.92567989
55	PDK2	0.90015836
56	TGFBR1	0.89442541
57	MAP3K12	0.83523044
58	MARK1	0.83225091
59	ERBB3	0.81376747
60	TAF1	0.78958684
61	PLK2	0.78506338
62	IRAK4	0.72399381
63	CDK7	0.71486465
64	ADRBK2	0.70116497
65	MAP2K7	0.68792070
66	PDK4	0.68364045
67	PDK3	0.68364045
68	ADRBK1	0.68034420
69	CHEK1	0.67162987
70	MST4	0.66903692
71	EPHA4	0.66088109
72	PAK3	0.64202847
73	ATR	0.63947854
74	PRKCI	0.63583978
75	BCR	0.62833271
76	OXSR1	0.61810864
77	CSNK2A1	0.61757464
78	CDK8	0.61541771
79	CSNK1G3	0.61251449
80	PRKCE	0.60216714
81	MUSK	0.56592568
82	NEK1	0.56547302
83	LIMK1	0.56444837
84	GRK7	0.54399776
85	TAOK3	0.53837171
86	CSNK2A2	0.53016269
87	LATS2	0.52853333
88	IRAK2	0.52426925
89	ABL2	0.52411605
90	RPS6KA5	0.51219489
91	PKN1	0.50944382
92	BMPR1B	0.50785544
93	BMPR2	0.49953133
94	MAPKAPK5	0.49825715
95	PAK1	0.49181254
96	NTRK2	0.48953383
97	TXK	0.47569361
98	CAMK2A	0.46951133
99	GRK5	0.44523494
100	DAPK2	0.43820899
101	MINK1	0.43176517
102	CAMK2B	0.42118343
103	MAPK13	0.41745344
104	CDK19	0.41665230
105	OBSCN	0.41325948
106	PRKACA	0.40003287
107	CDK1	0.38187230
108	PHKG2	0.37354473
109	PHKG1	0.37354473
110	WNK3	0.37008537
111	STK39	0.36969366
112	TNIK	0.36934889
113	TIE1	0.36934324
114	CSNK1G1	0.36924235
115	CAMK1	0.36135974
116	CDK2	0.36016947
117	ATM	0.35513557
118	CAMK2G	0.35460964
119	PRKCG	0.35255647
120	YES1	0.35218882
121	CSNK1D	0.34648782
122	CSNK1A1L	0.33739059
123	GRK1	0.31058393
124	CSNK1E	0.30877861
125	STK24	0.30722976
126	CAMKK2	0.28208819
127	CSNK1G2	0.28145411
128	STK4	0.26239493
129	MARK3	0.25093233
130	CSNK1A1	0.24977430
131	RPS6KA4	0.24679410

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	RNA polymerase_Homo sapiens_hsa03020	5.20130251
2	Proteasome_Homo sapiens_hsa03050	4.61088138
3	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	4.04196566
4	Vitamin B6 metabolism_Homo sapiens_hsa00750	3.95762234
5	Ribosome_Homo sapiens_hsa03010	3.34384799
6	Pyrimidine metabolism_Homo sapiens_hsa00240	2.85917127
7	DNA replication_Homo sapiens_hsa03030	2.84600464
8	RNA transport_Homo sapiens_hsa03013	2.68566119
9	Spliceosome_Homo sapiens_hsa03040	2.62757589
10	Basal transcription factors_Homo sapiens_hsa03022	2.60139115
11	Homologous recombination_Homo sapiens_hsa03440	2.55685153
12	Mismatch repair_Homo sapiens_hsa03430	2.55288402
13	Oxidative phosphorylation_Homo sapiens_hsa00190	2.51025787
14	Fanconi anemia pathway_Homo sapiens_hsa03460	2.32960495
15	Nucleotide excision repair_Homo sapiens_hsa03420	2.21056247
16	Cell cycle_Homo sapiens_hsa04110	2.05693056
17	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.03818283
18	Parkinsons disease_Homo sapiens_hsa05012	2.02963013
19	Purine metabolism_Homo sapiens_hsa00230	1.92353290
20	Huntingtons disease_Homo sapiens_hsa05016	1.92103981
21	Base excision repair_Homo sapiens_hsa03410	1.80151304
22	Protein export_Homo sapiens_hsa03060	1.65943179
23	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.62489917
24	Butanoate metabolism_Homo sapiens_hsa00650	1.58761559
25	Regulation of autophagy_Homo sapiens_hsa04140	1.57769051
26	RNA degradation_Homo sapiens_hsa03018	1.57591423
27	Propanoate metabolism_Homo sapiens_hsa00640	1.47012735
28	Alzheimers disease_Homo sapiens_hsa05010	1.31824611
29	Non-homologous end-joining_Homo sapiens_hsa03450	1.28982143
30	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.28408885
31	p53 signaling pathway_Homo sapiens_hsa04115	1.27492960
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.25481166
33	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.19470474
34	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.18870675
35	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.17764307
36	Epstein-Barr virus infection_Homo sapiens_hsa05169	1.17460365
37	Collecting duct acid secretion_Homo sapiens_hsa04966	1.15546343
38	Nitrogen metabolism_Homo sapiens_hsa00910	1.10615629
39	Tryptophan metabolism_Homo sapiens_hsa00380	1.09161624
40	mRNA surveillance pathway_Homo sapiens_hsa03015	1.04387365
41	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.02430378
42	Oocyte meiosis_Homo sapiens_hsa04114	1.02089646
43	Folate biosynthesis_Homo sapiens_hsa00790	0.99210589
44	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.98870484
45	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.98694910
46	Selenocompound metabolism_Homo sapiens_hsa00450	0.97957218
47	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.96403102
48	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.86517024
49	Caffeine metabolism_Homo sapiens_hsa00232	0.85061418
50	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.82802862
51	Pentose phosphate pathway_Homo sapiens_hsa00030	0.79566524
52	Pyruvate metabolism_Homo sapiens_hsa00620	0.78772028
53	Peroxisome_Homo sapiens_hsa04146	0.77830959
54	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.75246421
55	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.75023711
56	One carbon pool by folate_Homo sapiens_hsa00670	0.74365630
57	Olfactory transduction_Homo sapiens_hsa04740	0.73915942
58	Phototransduction_Homo sapiens_hsa04744	0.73357804
59	Chemical carcinogenesis_Homo sapiens_hsa05204	0.71038581
60	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.69299719
61	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.69119040
62	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.68449912
63	Morphine addiction_Homo sapiens_hsa05032	0.68159543
64	Nicotine addiction_Homo sapiens_hsa05033	0.67897709
65	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.67291582
66	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.67129492
67	Sphingolipid metabolism_Homo sapiens_hsa00600	0.66636935
68	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.66409256
69	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.65900579
70	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.65436183
71	GABAergic synapse_Homo sapiens_hsa04727	0.65424572
72	Metabolic pathways_Homo sapiens_hsa01100	0.64395743
73	Cardiac muscle contraction_Homo sapiens_hsa04260	0.61638138
74	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.61562964
75	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.61144960
76	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.58701566
77	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.57518069
78	Rheumatoid arthritis_Homo sapiens_hsa05323	0.56627449
79	Retinol metabolism_Homo sapiens_hsa00830	0.54301213
80	Ether lipid metabolism_Homo sapiens_hsa00565	0.53134669
81	beta-Alanine metabolism_Homo sapiens_hsa00410	0.50005867
82	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.48422124
83	Glutathione metabolism_Homo sapiens_hsa00480	0.47786955
84	Linoleic acid metabolism_Homo sapiens_hsa00591	0.47490713
85	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.46046316
86	Sulfur metabolism_Homo sapiens_hsa00920	0.45182352
87	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.44531338
88	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.40718083
89	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.39249676
90	Glutamatergic synapse_Homo sapiens_hsa04724	0.35558776
91	Basal cell carcinoma_Homo sapiens_hsa05217	0.34100867
92	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.34076598
93	Fatty acid degradation_Homo sapiens_hsa00071	0.33853034
94	Vibrio cholerae infection_Homo sapiens_hsa05110	0.33611257
95	Sulfur relay system_Homo sapiens_hsa04122	0.32485280
96	Circadian entrainment_Homo sapiens_hsa04713	0.31498626
97	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.30285294
98	Allograft rejection_Homo sapiens_hsa05330	0.29954046
99	Fatty acid metabolism_Homo sapiens_hsa01212	0.29569761
100	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.28072178
101	Fat digestion and absorption_Homo sapiens_hsa04975	0.25823868
102	Steroid biosynthesis_Homo sapiens_hsa00100	0.25534384
103	Arginine and proline metabolism_Homo sapiens_hsa00330	0.25070394
104	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.25000036
105	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.23828468
106	Taste transduction_Homo sapiens_hsa04742	0.23485106
107	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.23180275
108	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.22647774
109	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.22073773
110	Herpes simplex infection_Homo sapiens_hsa05168	0.21281664
111	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.20391172
112	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.19480806
113	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.19144058
114	Fatty acid elongation_Homo sapiens_hsa00062	0.18527629
115	Graft-versus-host disease_Homo sapiens_hsa05332	0.16938488
116	Circadian rhythm_Homo sapiens_hsa04710	0.14832132
117	Asthma_Homo sapiens_hsa05310	0.12382506
118	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.11929409
119	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.11868125
120	Serotonergic synapse_Homo sapiens_hsa04726	0.11800520
121	Viral carcinogenesis_Homo sapiens_hsa05203	0.11461182
122	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.11173194
123	Phagosome_Homo sapiens_hsa04145	0.10490656
124	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.10181881
125	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.06296094
126	Alcoholism_Homo sapiens_hsa05034	0.06233819
127	Primary immunodeficiency_Homo sapiens_hsa05340	0.06233336
128	Type I diabetes mellitus_Homo sapiens_hsa04940	0.04678325
129	Antigen processing and presentation_Homo sapiens_hsa04612	0.03914005
130	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.03011839
131	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.02836172
132	HTLV-I infection_Homo sapiens_hsa05166	-0.0461948
133	NF-kappa B signaling pathway_Homo sapiens_hsa04064	-0.0448948
134	Cyanoamino acid metabolism_Homo sapiens_hsa00460	-0.0222133
135	Amphetamine addiction_Homo sapiens_hsa05031	-0.0116079

ZNHIT3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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