ZNRF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an E3 ubiquitin-protein ligase that plays a role in neural-cell differentiation. Overexpression of this gene causes neurite-like elongation. The encoded protein contains both a zinc finger and a RING finger motif and is localized in the endosome/lysosome compartment, indicating that it may be involved in ubiquitin-mediated protein modification, and in synaptic vessicle membranes in neurons. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)4.97127506
2synaptic vesicle maturation (GO:0016188)4.83364605
3ribosomal small subunit biogenesis (GO:0042274)4.65768802
4negative regulation of cell killing (GO:0031342)4.47226058
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.47226058
6viral transcription (GO:0019083)4.22959082
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.18914682
8layer formation in cerebral cortex (GO:0021819)4.18640099
9regulation of synapse structural plasticity (GO:0051823)4.06549840
10translational termination (GO:0006415)4.04220635
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.03808823
12regulation of short-term neuronal synaptic plasticity (GO:0048172)3.96624434
13positive regulation of gamma-delta T cell activation (GO:0046645)3.92240035
14regulation of gamma-delta T cell differentiation (GO:0045586)3.83075038
15activated T cell proliferation (GO:0050798)3.75981810
16regulation of glutamate receptor signaling pathway (GO:1900449)3.68669041
17G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.63102780
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.59136469
19dendritic spine morphogenesis (GO:0060997)3.55948722
20positive regulation of synapse maturation (GO:0090129)3.54511425
21regulation of gamma-delta T cell activation (GO:0046643)3.53199031
22regulation of ARF protein signal transduction (GO:0032012)3.49922017
23exploration behavior (GO:0035640)3.45648269
24translational elongation (GO:0006414)3.42460312
25positive T cell selection (GO:0043368)3.40322887
26regulation of ARF GTPase activity (GO:0032312)3.36948203
27vocalization behavior (GO:0071625)3.34909077
28mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.32620846
29T cell selection (GO:0045058)3.31318814
30synaptic vesicle exocytosis (GO:0016079)3.27720411
31activation of protein kinase A activity (GO:0034199)3.27300679
32establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.25259281
33mitochondrion transport along microtubule (GO:0047497)3.25259281
34nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.22534962
35adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.18359333
36negative regulation of erythrocyte differentiation (GO:0045647)3.18238998
37clathrin coat assembly (GO:0048268)3.17911845
38glutamate secretion (GO:0014047)3.16337061
39regulation of synaptic vesicle exocytosis (GO:2000300)3.15871664
40protein targeting to ER (GO:0045047)3.14615143
41viral life cycle (GO:0019058)3.14490350
42negative T cell selection (GO:0043383)3.14244816
43dendrite morphogenesis (GO:0048813)3.14034350
44cotranslational protein targeting to membrane (GO:0006613)3.12313434
45regulation of long-term neuronal synaptic plasticity (GO:0048169)3.11898838
46positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.10461301
47cellular protein complex disassembly (GO:0043624)3.09956205
48SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.09891952
49positive regulation of Rap GTPase activity (GO:0032854)3.07896289
50protein localization to synapse (GO:0035418)3.07432305
51synaptic vesicle docking involved in exocytosis (GO:0016081)3.06118352
52ionotropic glutamate receptor signaling pathway (GO:0035235)3.05212626
53establishment of protein localization to endoplasmic reticulum (GO:0072599)3.03183701
54neuron cell-cell adhesion (GO:0007158)3.02310525
55substrate-independent telencephalic tangential migration (GO:0021826)2.98790331
56substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.98790331
57nerve growth factor signaling pathway (GO:0038180)2.97351330
58mucosal-associated lymphoid tissue development (GO:0048537)2.95429556
59Peyers patch development (GO:0048541)2.95429556
60protein localization to endoplasmic reticulum (GO:0070972)2.94590524
61establishment of mitochondrion localization (GO:0051654)2.93824190
62protein complex disassembly (GO:0043241)2.93051548
63prepulse inhibition (GO:0060134)2.92215910
64regulation of neuronal synaptic plasticity (GO:0048168)2.91981420
65regulation of Rap GTPase activity (GO:0032317)2.91254461
66ATP synthesis coupled proton transport (GO:0015986)2.88782560
67energy coupled proton transport, down electrochemical gradient (GO:0015985)2.88782560
68presynaptic membrane organization (GO:0097090)2.87342252
69postsynaptic membrane organization (GO:0001941)2.86144797
70regulation of dendritic spine morphogenesis (GO:0061001)2.84989377
71antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.84639163
72antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.84639163
73regulation of synaptic vesicle transport (GO:1902803)2.84280667
74positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.83471713
75mast cell activation involved in immune response (GO:0002279)2.81438587
76mast cell degranulation (GO:0043303)2.81438587
77macromolecular complex disassembly (GO:0032984)2.79203452
78neurotransmitter secretion (GO:0007269)2.78989281
79long-term memory (GO:0007616)2.78390007
80regulation of synapse maturation (GO:0090128)2.76281599
81neuromuscular process controlling balance (GO:0050885)2.74426274
82positive regulation of dendritic spine morphogenesis (GO:0061003)2.74006301
83translational initiation (GO:0006413)2.73747044
84thymic T cell selection (GO:0045061)2.73350699
85positive regulation of membrane potential (GO:0045838)2.73094678
86cellular response to nerve growth factor stimulus (GO:1990090)2.72561906
87response to nerve growth factor (GO:1990089)2.72561906
88positive thymic T cell selection (GO:0045059)2.71692971
89negative thymic T cell selection (GO:0045060)2.71553112
90cell migration in hindbrain (GO:0021535)2.69425962
91sodium ion export (GO:0071436)2.67703427
92T cell receptor signaling pathway (GO:0050852)2.65071743
93establishment of protein localization to mitochondrial membrane (GO:0090151)2.64801993
94regulation of membrane repolarization (GO:0060306)2.64278521
95membrane repolarization during action potential (GO:0086011)2.60645542
96neuronal ion channel clustering (GO:0045161)2.57368274
97phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.57282809
98protein localization to endosome (GO:0036010)2.57244469
99sarcoplasmic reticulum calcium ion transport (GO:0070296)2.57122110
100dopamine receptor signaling pathway (GO:0007212)2.56037585
101gamma-aminobutyric acid transport (GO:0015812)2.55838347
102cerebellar Purkinje cell differentiation (GO:0021702)2.54889942
103regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.53241034
104neurotransmitter catabolic process (GO:0042135)2.52714630
105auditory behavior (GO:0031223)2.52297547
106regulation of dendritic spine development (GO:0060998)2.49456165
107skeletal muscle contraction (GO:0003009)2.49332613
108ribosomal small subunit assembly (GO:0000028)2.49125504
109transmission of nerve impulse (GO:0019226)2.48866722
110regulation of defense response to virus by virus (GO:0050690)2.48057944
111cytoskeletal anchoring at plasma membrane (GO:0007016)2.47970467
112positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.47412842
113neuron recognition (GO:0008038)2.45899025
114electron transport chain (GO:0022900)2.45746021
115mast cell activation (GO:0045576)2.45392433
116regulation of excitatory postsynaptic membrane potential (GO:0060079)2.45204268
117behavioral response to nicotine (GO:0035095)2.45083544
118signal complex assembly (GO:0007172)2.44966710
119regulation of skeletal muscle contraction (GO:0014819)2.44483666
120positive regulation of synaptic transmission, GABAergic (GO:0032230)2.44169837
121respiratory electron transport chain (GO:0022904)2.43558009
122mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.43316304
123synaptic transmission, glutamatergic (GO:0035249)2.43185123
124chaperone-mediated protein transport (GO:0072321)2.42481878
125body morphogenesis (GO:0010171)2.42481451
126cAMP biosynthetic process (GO:0006171)2.41694184
127neurotransmitter-gated ion channel clustering (GO:0072578)2.41524511
128negative regulation of cell size (GO:0045792)2.41270820
129glutamate receptor signaling pathway (GO:0007215)2.40867727
130axonal fasciculation (GO:0007413)2.40248270
131V(D)J recombination (GO:0033151)2.39919511
132regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.39896941
133membrane tubulation (GO:0097320)2.39686615
134positive regulation of histone deacetylation (GO:0031065)2.37470165
135angiogenesis involved in wound healing (GO:0060055)2.37083571
136central nervous system projection neuron axonogenesis (GO:0021952)2.35944850
137membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.35200167
138positive regulation of neurotransmitter secretion (GO:0001956)2.35167098
139regulation of regulatory T cell differentiation (GO:0045589)2.34699016
140regulation of cell proliferation involved in kidney development (GO:1901722)2.34558222
141establishment or maintenance of monopolar cell polarity (GO:0061339)2.34542825
142establishment of monopolar cell polarity (GO:0061162)2.34542825
143spinal cord development (GO:0021510)2.34151282
144mechanosensory behavior (GO:0007638)2.33966724
145regulation of synaptic plasticity (GO:0048167)2.32840133
146proline transport (GO:0015824)2.31049800
147negative regulation of thymocyte apoptotic process (GO:0070244)2.30623619
148regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.30176166
149histone H3-K4 trimethylation (GO:0080182)2.30153849
150cell-cell junction maintenance (GO:0045217)2.29192597
151positive regulation of dendritic spine development (GO:0060999)2.29087692
152pyrimidine nucleobase catabolic process (GO:0006208)2.29035862
153negative regulation of axonogenesis (GO:0050771)2.26308260
154negative regulation of microtubule polymerization (GO:0031115)2.25523781
155synaptic transmission, cholinergic (GO:0007271)2.24504387
156axon extension (GO:0048675)2.20979116
157neuromuscular process controlling posture (GO:0050884)2.18925303
158potassium ion export (GO:0071435)2.18391903
159cerebellar Purkinje cell layer development (GO:0021680)2.17159858
160protein targeting to membrane (GO:0006612)2.17020084
161ribosomal large subunit biogenesis (GO:0042273)2.15555396
162embryonic retina morphogenesis in camera-type eye (GO:0060059)2.15177083
163response to auditory stimulus (GO:0010996)2.15088912
164genetic imprinting (GO:0071514)2.14815320
165positive regulation of gastrulation (GO:2000543)2.13050235
166presynaptic membrane assembly (GO:0097105)2.11985242
167membrane repolarization (GO:0086009)2.11173919
168retinal ganglion cell axon guidance (GO:0031290)2.11034492
169activation of protein kinase B activity (GO:0032148)2.10992632
170protein insertion into membrane (GO:0051205)2.10832190
171membrane depolarization during action potential (GO:0086010)2.09806667
172synapse assembly (GO:0007416)2.08364058
173negative regulation of organelle assembly (GO:1902116)2.07378962
174maturation of SSU-rRNA (GO:0030490)2.06999532
175cranial nerve morphogenesis (GO:0021602)2.04269735
176translation (GO:0006412)2.04161042
177negative regulation of response to food (GO:0032096)2.03802187
178negative regulation of appetite (GO:0032099)2.03802187
179nucleosome disassembly (GO:0006337)2.03396910
180protein-DNA complex disassembly (GO:0032986)2.03396910

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.89840747
2EZH2_22144423_ChIP-Seq_EOC_Human3.38138026
3* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.28742985
4ESR1_15608294_ChIP-ChIP_MCF-7_Human3.27386445
5* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.75255474
6DROSHA_22980978_ChIP-Seq_HELA_Human2.68364452
7ZNF263_19887448_ChIP-Seq_K562_Human2.67185341
8EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.66613733
9* RARB_27405468_Chip-Seq_BRAIN_Mouse2.61371475
10* KDM2B_26808549_Chip-Seq_DND41_Human2.57768232
11TCF7_22412390_ChIP-Seq_EML_Mouse2.50323012
12MYC_22102868_ChIP-Seq_BL_Human2.44092437
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.34542005
14VDR_21846776_ChIP-Seq_THP-1_Human2.28755089
15VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.17527370
16KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.16995822
17RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.16294083
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.14246254
19JARID2_20064375_ChIP-Seq_MESCs_Mouse2.10024060
20* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.09401543
21* SCL_19346495_ChIP-Seq_HPC-7_Human2.06103688
22STAT6_21828071_ChIP-Seq_BEAS2B_Human2.05628790
23KDM2B_26808549_Chip-Seq_JURKAT_Human2.04326611
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.02887387
25ESR1_21235772_ChIP-Seq_MCF-7_Human2.00967127
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.00579426
27KDM2B_26808549_Chip-Seq_K562_Human1.99706123
28RUNX_20019798_ChIP-Seq_JUKART_Human1.96938508
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.95364207
30DNAJC2_21179169_ChIP-ChIP_NT2_Human1.94017764
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.90698243
32WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.90650278
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.86264120
34SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.84865188
35MTF2_20144788_ChIP-Seq_MESCs_Mouse1.84665826
36RNF2_18974828_ChIP-Seq_MESCs_Mouse1.84600705
37EZH2_18974828_ChIP-Seq_MESCs_Mouse1.84600705
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81598554
39SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.81553147
40GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.81240593
41FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.81079509
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.79183581
43MYC_18555785_ChIP-Seq_MESCs_Mouse1.77045543
44* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.76955474
45ZFP281_18757296_ChIP-ChIP_E14_Mouse1.76815314
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.75810700
47LXR_22292898_ChIP-Seq_THP-1_Human1.75596751
48TP53_20018659_ChIP-ChIP_R1E_Mouse1.75415719
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.72922532
50VDR_24763502_ChIP-Seq_THP-1_Human1.72447829
51BP1_19119308_ChIP-ChIP_Hs578T_Human1.70079629
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.68160320
53ZFP281_27345836_Chip-Seq_ESCs_Mouse1.68140363
54UTX_26944678_Chip-Seq_JUKART_Human1.67039867
55* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.66878426
56JARID2_20075857_ChIP-Seq_MESCs_Mouse1.65523581
57MAF_26560356_Chip-Seq_TH1_Human1.64441554
58REST_21632747_ChIP-Seq_MESCs_Mouse1.62409276
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.62297431
60* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.60282179
61RNF2_27304074_Chip-Seq_ESCs_Mouse1.60184325
62SPI1_23127762_ChIP-Seq_K562_Human1.59099018
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57158574
64SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.54991346
65* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.54437212
66ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.52262381
67E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50945274
68* ELK3_25401928_ChIP-Seq_HUVEC_Human1.50860857
69* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.49983745
70SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.45971508
71DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.43660977
72ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.42433163
73SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.39440727
74REST_18959480_ChIP-ChIP_MESCs_Mouse1.39291600
75EED_16625203_ChIP-ChIP_MESCs_Mouse1.37403466
76RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.37398203
77E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.37107283
78EZH2_27304074_Chip-Seq_ESCs_Mouse1.35792327
79XRN2_22483619_ChIP-Seq_HELA_Human1.35588588
80AR_21572438_ChIP-Seq_LNCaP_Human1.35247510
81SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.34771089
82* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.34737947
83TP63_19390658_ChIP-ChIP_HaCaT_Human1.34379512
84CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.34353249
85P68_20966046_ChIP-Seq_HELA_Human1.31026190
86RNF2_27304074_Chip-Seq_NSC_Mouse1.30177982
87BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29963586
88TET1_21451524_ChIP-Seq_MESCs_Mouse1.29841940
89MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.29635198
90TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.29047797
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28267532
92* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27213585
93STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.25954516
94THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25343891
95EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.24250271
96WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23985584
97MYC_19079543_ChIP-ChIP_MESCs_Mouse1.23950171
98GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23067482
99DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19343599
100KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19307911
101OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.17988326
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16500751
103* FOXP1_21924763_ChIP-Seq_HESCs_Human1.15092623
104RING1B_27294783_Chip-Seq_ESCs_Mouse1.15058612
105GATA1_19941827_ChIP-Seq_MEL_Mouse1.14964579
106MYC_18358816_ChIP-ChIP_MESCs_Mouse1.14784129
107ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14288505
108FOXM1_23109430_ChIP-Seq_U2OS_Human1.12750821
109SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12561426
110MAF_26560356_Chip-Seq_TH2_Human1.12394317
111* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11607793
112GATA1_19941826_ChIP-Seq_K562_Human1.10995292
113MYB_26560356_Chip-Seq_TH2_Human1.10791551
114NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.10694437
115GATA1_26923725_Chip-Seq_HPCs_Mouse1.10450075
116ETS1_20019798_ChIP-Seq_JURKAT_Human1.09357759
117STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.08545813
118MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08396950
119RUNX1_22412390_ChIP-Seq_EML_Mouse1.07947663
120ERG_21242973_ChIP-ChIP_JURKAT_Human1.06634861
121DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05932090
122JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.05864441
123* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05162413
124TTF2_22483619_ChIP-Seq_HELA_Human1.03561601
125PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.03424351
126SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03002062
127SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.02138366
128SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01339694
129HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00137148
130* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99871140
131CREB1_26743006_Chip-Seq_LNCaP_Human0.99246526
132SOX2_16153702_ChIP-ChIP_HESCs_Human0.98191284
133SOX3_22085726_ChIP-Seq_NPCs_Mouse0.97968013
134RING1B_27294783_Chip-Seq_NPCs_Mouse0.97605578
135MYC_19030024_ChIP-ChIP_MESCs_Mouse0.97532784
136TDRD3_21172665_ChIP-Seq_MCF-7_Human0.96850320
137P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95922122
138PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95209835
139NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95021709
140CTCF_27219007_Chip-Seq_Bcells_Human0.94572960
141CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94461810
142GATA3_27048872_Chip-Seq_THYMUS_Human0.94074915
143TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.92461945
144ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.91834340
145TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91812445
146RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.91485164
147* RUNX1_27514584_Chip-Seq_MCF-7_Human0.90690545
148SA1_27219007_Chip-Seq_ERYTHROID_Human0.90570499
149GATA2_21666600_ChIP-Seq_HMVEC_Human0.90125886
150SMAD_19615063_ChIP-ChIP_OVARY_Human0.89966620
151NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88962797
152* RACK7_27058665_Chip-Seq_MCF-7_Human0.88572140
153VDR_24787735_ChIP-Seq_THP-1_Human0.88518966
154MYB_26560356_Chip-Seq_TH1_Human0.87607732
155SMC4_20622854_ChIP-Seq_HELA_Human0.87421344
156NFIB_24661679_ChIP-Seq_LUNG_Mouse0.86503718
157BRD4_27068464_Chip-Seq_AML-cells_Mouse0.86272488
158CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.85868334
159ESR2_21235772_ChIP-Seq_MCF-7_Human0.81534427

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.78594170
2MP0003123_paternal_imprinting3.50964254
3MP0003635_abnormal_synaptic_transmissio3.22442338
4MP0009278_abnormal_bone_marrow2.92695282
5MP0009379_abnormal_foot_pigmentation2.92672381
6MP0003880_abnormal_central_pattern2.81021195
7MP0002822_catalepsy2.76505152
8MP0003303_peritoneal_inflammation2.74975442
9MP0004510_myositis2.59015959
10MP0009745_abnormal_behavioral_response2.46372135
11MP0004270_analgesia2.44732426
12MP0002063_abnormal_learning/memory/cond2.44238334
13MP0002064_seizures2.25597795
14MP0005423_abnormal_somatic_nervous2.25064531
15MP0005409_darkened_coat_color2.23363924
16MP0006292_abnormal_olfactory_placode2.20289779
17MP0000569_abnormal_digit_pigmentation2.14592277
18MP0008569_lethality_at_weaning2.13029749
19MP0001529_abnormal_vocalization2.12249959
20MP0000566_synostosis2.11906446
21MP0008877_abnormal_DNA_methylation1.99193882
22MP0003122_maternal_imprinting1.92809106
23MP0003763_abnormal_thymus_physiology1.89049719
24MP0008961_abnormal_basal_metabolism1.88593452
25MP0001486_abnormal_startle_reflex1.87362790
26MP0002572_abnormal_emotion/affect_behav1.82907128
27MP0001188_hyperpigmentation1.79186401
28MP0005174_abnormal_tail_pigmentation1.71899532
29MP0004858_abnormal_nervous_system1.70555336
30MP0009046_muscle_twitch1.67033348
31MP0002638_abnormal_pupillary_reflex1.64190489
32MP0003121_genomic_imprinting1.63778835
33MP0004808_abnormal_hematopoietic_stem1.61137860
34MP0003329_amyloid_beta_deposits1.60671799
35MP0003300_gastrointestinal_ulcer1.60479131
36MP0004811_abnormal_neuron_physiology1.59252320
37MP0001968_abnormal_touch/_nociception1.55647169
38MP0000685_abnormal_immune_system1.53906822
39MP0005397_hematopoietic_system_phenotyp1.52973381
40MP0001545_abnormal_hematopoietic_system1.52973381
41MP0004130_abnormal_muscle_cell1.51543689
42MP0000703_abnormal_thymus_morphology1.50921191
43MP0002249_abnormal_larynx_morphology1.49332038
44MP0005167_abnormal_blood-brain_barrier1.48760145
45MP0000920_abnormal_myelination1.48545496
46MP0009780_abnormal_chondrocyte_physiolo1.47265941
47MP0002272_abnormal_nervous_system1.44211588
48MP0001501_abnormal_sleep_pattern1.44065137
49MP0002734_abnormal_mechanical_nocicepti1.41894018
50MP0002166_altered_tumor_susceptibility1.41032854
51MP0000778_abnormal_nervous_system1.40984802
52MP0003942_abnormal_urinary_system1.37539902
53MP0001440_abnormal_grooming_behavior1.36243475
54MP0002733_abnormal_thermal_nociception1.35847321
55MP0003787_abnormal_imprinting1.35498715
56MP0003646_muscle_fatigue1.35307917
57MP0003172_abnormal_lysosome_physiology1.35006399
58MP0008874_decreased_physiological_sensi1.34588648
59MP0002396_abnormal_hematopoietic_system1.34285471
60MP0004133_heterotaxia1.34080974
61MP0002735_abnormal_chemical_nociception1.32107106
62MP0003075_altered_response_to1.32103111
63MP0005464_abnormal_platelet_physiology1.29800840
64MP0001970_abnormal_pain_threshold1.29558760
65MP0005671_abnormal_response_to1.27915942
66MP0003315_abnormal_perineum_morphology1.27465709
67MP0002557_abnormal_social/conspecific_i1.24667470
68MP0004885_abnormal_endolymph1.23883956
69MP0000751_myopathy1.23687466
70MP0005646_abnormal_pituitary_gland1.23386642
71MP0005386_behavior/neurological_phenoty1.23057229
72MP0004924_abnormal_behavior1.23057229
73MP0002938_white_spotting1.22801883
74MP0002184_abnormal_innervation1.21956847
75MP0002398_abnormal_bone_marrow1.21706282
76MP0002160_abnormal_reproductive_system1.20833824
77MP0000955_abnormal_spinal_cord1.20599672
78MP0008789_abnormal_olfactory_epithelium1.19933472
79MP0000749_muscle_degeneration1.19451707
80MP0004947_skin_inflammation1.19118653
81MP0005499_abnormal_olfactory_system1.16356199
82MP0005394_taste/olfaction_phenotype1.16356199
83MP0009785_altered_susceptibility_to1.16110209
84MP0000678_abnormal_parathyroid_gland1.13592071
85MP0003866_abnormal_defecation1.12686039
86MP0002067_abnormal_sensory_capabilities1.10832487
87MP0003633_abnormal_nervous_system1.09607160
88MP0003861_abnormal_nervous_system1.08245970
89MP0002420_abnormal_adaptive_immunity1.07655796
90MP0001348_abnormal_lacrimal_gland1.07054638
91MP0000465_gastrointestinal_hemorrhage1.06882718
92MP0001819_abnormal_immune_cell1.06307331
93MP0006276_abnormal_autonomic_nervous1.05952566
94MP0002653_abnormal_ependyma_morphology1.04304068
95MP0001944_abnormal_pancreas_morphology1.03646740
96MP0004185_abnormal_adipocyte_glucose1.03617336
97MP0002909_abnormal_adrenal_gland1.03270256
98MP0003879_abnormal_hair_cell1.02973625
99MP0002837_dystrophic_cardiac_calcinosis1.02675278
100MP0000604_amyloidosis0.98657440
101MP0002882_abnormal_neuron_morphology0.97591324
102MP0000716_abnormal_immune_system0.97372762
103MP0002723_abnormal_immune_serum0.97305290
104MP0002163_abnormal_gland_morphology0.97278914
105MP0001800_abnormal_humoral_immune0.96774237
106MP0003941_abnormal_skin_development0.95592186
107MP0000049_abnormal_middle_ear0.94632573
108MP0000462_abnormal_digestive_system0.94504109
109MP0003890_abnormal_embryonic-extraembry0.94213433
110MP0002006_tumorigenesis0.93860165
111MP0010155_abnormal_intestine_physiology0.93441980
112MP0009672_abnormal_birth_weight0.93096789
113MP0002066_abnormal_motor_capabilities/c0.92813100
114MP0005000_abnormal_immune_tolerance0.92448769
115MP0001485_abnormal_pinna_reflex0.92304246
116MP0005025_abnormal_response_to0.90749305
117MP0010030_abnormal_orbit_morphology0.90240118
118MP0002722_abnormal_immune_system0.88763531
119MP0005076_abnormal_cell_differentiation0.88320227
120MP0002796_impaired_skin_barrier0.87973214
121MP0002116_abnormal_craniofacial_bone0.87262666
122MP0009250_abnormal_appendicular_skeleto0.87169981
123MP0001984_abnormal_olfaction0.87009959
124MP0002210_abnormal_sex_determination0.86578015
125MP0004742_abnormal_vestibular_system0.86432127
126MP0003938_abnormal_ear_development0.86037200
127MP0005387_immune_system_phenotype0.86003453
128MP0001790_abnormal_immune_system0.86003453
129MP0002752_abnormal_somatic_nervous0.85991982
130MP0004142_abnormal_muscle_tone0.85002455
131MP0002736_abnormal_nociception_after0.84945951
132MP0001849_ear_inflammation0.83833407
133MP0002452_abnormal_antigen_presenting0.83563520
134MP0000015_abnormal_ear_pigmentation0.82347821
135MP0002152_abnormal_brain_morphology0.81619175
136MP0002419_abnormal_innate_immunity0.80505720
137MP0000631_abnormal_neuroendocrine_gland0.79786394
138MP0000026_abnormal_inner_ear0.78502400
139MP0008770_decreased_survivor_rate0.77998946
140MP0004145_abnormal_muscle_electrophysio0.77482895
141MP0003631_nervous_system_phenotype0.77456754
142MP0001664_abnormal_digestion0.77420312
143MP0002106_abnormal_muscle_physiology0.75880781
144MP0003690_abnormal_glial_cell0.75702418
145MP0008995_early_reproductive_senescence0.75128712
146MP0000750_abnormal_muscle_regeneration0.74989694
147MP0002081_perinatal_lethality0.74844894
148MP0000689_abnormal_spleen_morphology0.74374498
149MP0005166_decreased_susceptibility_to0.73354787
150MP0006036_abnormal_mitochondrial_physio0.72915210
151MP0001851_eye_inflammation0.71049955
152MP0001293_anophthalmia0.70800804
153MP0001905_abnormal_dopamine_level0.70770562
154MP0003698_abnormal_male_reproductive0.70606371
155MP0002429_abnormal_blood_cell0.69591152
156MP0002089_abnormal_postnatal_growth/wei0.69585849
157MP0002751_abnormal_autonomic_nervous0.67660280

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)3.95936826
2Supranuclear gaze palsy (HP:0000605)3.77612914
3Hyperacusis (HP:0010780)3.73600156
4Panhypogammaglobulinemia (HP:0003139)3.69164233
5Visual hallucinations (HP:0002367)3.59863261
6Reticulocytopenia (HP:0001896)3.45331092
7Abnormality of cells of the erythroid lineage (HP:0012130)3.42450394
8B lymphocytopenia (HP:0010976)3.24022648
9Abnormality of B cell number (HP:0010975)3.24022648
10Thyroiditis (HP:0100646)3.23964837
11Papilledema (HP:0001085)3.23182899
12T lymphocytopenia (HP:0005403)3.17983547
13Limb dystonia (HP:0002451)3.08727958
14Focal seizures (HP:0007359)3.02382962
15Mutism (HP:0002300)2.99515377
16Focal motor seizures (HP:0011153)2.96059614
17Abnormality of T cell number (HP:0011839)2.95726778
18Recurrent viral infections (HP:0004429)2.92322812
19Ankle clonus (HP:0011448)2.88373872
20Abnormal number of erythroid precursors (HP:0012131)2.83900699
21Chronic otitis media (HP:0000389)2.81997508
22Recurrent fungal infections (HP:0002841)2.75739905
23Hyperthyroidism (HP:0000836)2.71910219
24Elevated erythrocyte sedimentation rate (HP:0003565)2.70538801
25Renal Fanconi syndrome (HP:0001994)2.68055751
26Broad-based gait (HP:0002136)2.66223974
27Enlarged penis (HP:0000040)2.65507114
28Insomnia (HP:0100785)2.64956201
29Hypoplasia of the thymus (HP:0000778)2.62816512
30Elfin facies (HP:0004428)2.58889861
31Severe combined immunodeficiency (HP:0004430)2.57658990
32Pointed chin (HP:0000307)2.55900375
33Annular pancreas (HP:0001734)2.53894419
34Stereotypic behavior (HP:0000733)2.53420318
35Muscle fiber inclusion bodies (HP:0100299)2.49519394
36Macroorchidism (HP:0000053)2.48234718
37Overriding aorta (HP:0002623)2.43495420
38Urinary urgency (HP:0000012)2.43131425
39Myopathic facies (HP:0002058)2.43032302
40Fetal akinesia sequence (HP:0001989)2.42996030
41Muscle hypertrophy of the lower extremities (HP:0008968)2.42690361
42Eosinophilia (HP:0001880)2.42125950
43Failure to thrive in infancy (HP:0001531)2.37575859
44Poor suck (HP:0002033)2.37329993
45Facial hemangioma (HP:0000329)2.35845754
46Progressive inability to walk (HP:0002505)2.33823174
47Depression (HP:0000716)2.31924352
48Apathy (HP:0000741)2.31871785
49Spastic gait (HP:0002064)2.29376354
50Obstructive sleep apnea (HP:0002870)2.28109584
51Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.27601464
52Abnormal social behavior (HP:0012433)2.26178724
53Impaired social interactions (HP:0000735)2.26178724
54Macrocytic anemia (HP:0001972)2.25891398
55Urinary bladder sphincter dysfunction (HP:0002839)2.25516465
56Rimmed vacuoles (HP:0003805)2.24475567
57Lower limb amyotrophy (HP:0007210)2.24325916
58Inappropriate behavior (HP:0000719)2.19406041
59Hemiplegia (HP:0002301)2.18889730
60Nemaline bodies (HP:0003798)2.18505461
61Poor eye contact (HP:0000817)2.17745180
62Postural instability (HP:0002172)2.17428613
63Diminished motivation (HP:0000745)2.16627527
64Genetic anticipation (HP:0003743)2.16564775
65Impaired vibration sensation in the lower limbs (HP:0002166)2.16029321
66Stomatitis (HP:0010280)2.14481532
67Pallor (HP:0000980)2.13686285
68Diplopia (HP:0000651)2.13463286
69Abnormality of binocular vision (HP:0011514)2.13463286
70Hypercortisolism (HP:0001578)2.13084066
71Dysmetria (HP:0001310)2.10124581
72Acute lymphatic leukemia (HP:0006721)2.09696695
73Abnormality of eosinophils (HP:0001879)2.07372199
74Septate vagina (HP:0001153)2.06255420
75Testicular atrophy (HP:0000029)2.06015361
76Calf muscle hypertrophy (HP:0008981)2.05109513
77Hepatoblastoma (HP:0002884)2.04475749
78Abnormality of the fingertips (HP:0001211)1.97696721
79Abnormality of reticulocytes (HP:0004312)1.96827355
80Abnormality of the corticospinal tract (HP:0002492)1.95210382
81Progressive cerebellar ataxia (HP:0002073)1.95062701
82Epileptic encephalopathy (HP:0200134)1.95041045
83Abnormality of oral frenula (HP:0000190)1.95006283
84Patellar aplasia (HP:0006443)1.92999929
85Renovascular hypertension (HP:0100817)1.92998372
86Chronic mucocutaneous candidiasis (HP:0002728)1.92796005
87Recurrent cutaneous fungal infections (HP:0011370)1.92796005
88Action tremor (HP:0002345)1.91883793
89Combined immunodeficiency (HP:0005387)1.91835338
90Increased hepatocellular lipid droplets (HP:0006565)1.89481154
91Aplasia/Hypoplasia of the patella (HP:0006498)1.88031157
92Abnormal delayed hypersensitivity skin test (HP:0002963)1.87992458
93Abnormality of the aortic arch (HP:0012303)1.87062228
94Amyotrophic lateral sclerosis (HP:0007354)1.87023072
95Torticollis (HP:0000473)1.86956483
96Reduced antithrombin III activity (HP:0001976)1.86871589
97Obsessive-compulsive behavior (HP:0000722)1.86591538
98Abnormality of the nasal mucosa (HP:0000433)1.86504783
99Acute necrotizing encephalopathy (HP:0006965)1.85998633
100Myositis (HP:0100614)1.85950279
101Neuronal loss in central nervous system (HP:0002529)1.85802350
102Sacral dimple (HP:0000960)1.85304976
103Atonic seizures (HP:0010819)1.84567328
104Leukocytosis (HP:0001974)1.83937902
105Hypoproteinemia (HP:0003075)1.83669675
106Chest pain (HP:0100749)1.83139345
107Decreased activity of mitochondrial respiratory chain (HP:0008972)1.82945010
108Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.82945010
109Lipid accumulation in hepatocytes (HP:0006561)1.82804976
110Drooling (HP:0002307)1.82766044
111Excessive salivation (HP:0003781)1.82766044
112Exercise-induced myalgia (HP:0003738)1.82381650
113Rapidly progressive (HP:0003678)1.81415940
114Concave nail (HP:0001598)1.81166792
115Ankyloglossia (HP:0010296)1.81156922
116Cerebral inclusion bodies (HP:0100314)1.81019708
117Akinesia (HP:0002304)1.80648406
118Flat cornea (HP:0007720)1.79888926
119Intention tremor (HP:0002080)1.79424829
120Absent thumb (HP:0009777)1.78551908
121Hyperphosphatemia (HP:0002905)1.78194344
122Febrile seizures (HP:0002373)1.77355597
123Neurofibrillary tangles (HP:0002185)1.76994049
124Verrucae (HP:0200043)1.76820045
125Papilloma (HP:0012740)1.76820045
126Prolonged QT interval (HP:0001657)1.75660171
127Abnormality of renal resorption (HP:0011038)1.75089982
128Abnormality of T cells (HP:0002843)1.75079574
129Granulocytopenia (HP:0001913)1.74912093
130Rib fusion (HP:0000902)1.74663447
131Increased intramyocellular lipid droplets (HP:0012240)1.74570803
132Slow saccadic eye movements (HP:0000514)1.74325695
133Aplasia/Hypoplasia of the brainstem (HP:0007362)1.73722178
134Hypoplasia of the brainstem (HP:0002365)1.73722178
135Exercise-induced muscle cramps (HP:0003710)1.72780291
136Dysmetric saccades (HP:0000641)1.72738397
137Anxiety (HP:0000739)1.72260416
138Abnormal mitochondria in muscle tissue (HP:0008316)1.71394768
139Polyphagia (HP:0002591)1.71158403
140High anterior hairline (HP:0009890)1.70558711
141Generalized hypotonia (HP:0001290)1.70198466
142Neoplasm of the heart (HP:0100544)1.69735093
143Open mouth (HP:0000194)1.69682063
144Aplasia/Hypoplasia of the sacrum (HP:0008517)1.69354212
145Difficulty running (HP:0009046)1.69236121
146Abnormality of saccadic eye movements (HP:0000570)1.69101025
147Absence seizures (HP:0002121)1.68506349
148Spinal canal stenosis (HP:0003416)1.68409045
149Truncal ataxia (HP:0002078)1.68298608
150Cerebral aneurysm (HP:0004944)1.67904623
151Slender long bone (HP:0003100)1.67860228
152Frequent falls (HP:0002359)1.67660330
153Ventricular fibrillation (HP:0001663)1.64272533
154Truncus arteriosus (HP:0001660)1.63808807
155Nephronophthisis (HP:0000090)1.63776160
156Type 1 muscle fiber predominance (HP:0003803)1.63534985
157Abnormality of homocysteine metabolism (HP:0010919)1.62572720
158Homocystinuria (HP:0002156)1.62572720
159Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.62123858
160Hyperparathyroidism (HP:0000843)1.60960657
161Bulbar palsy (HP:0001283)1.58864581
162Syncope (HP:0001279)1.57154302
163Osteomalacia (HP:0002749)1.57067883
164Acute encephalopathy (HP:0006846)1.56278451
165Abnormal urine phosphate concentration (HP:0012599)1.54979235
166Mitochondrial inheritance (HP:0001427)1.54680146
167Distal arthrogryposis (HP:0005684)1.51367840
168Increased muscle lipid content (HP:0009058)1.51253902
169Round ear (HP:0100830)1.49857801
170Generalized aminoaciduria (HP:0002909)1.49111881
171Hypophosphatemic rickets (HP:0004912)1.48905463
172Diaphragmatic weakness (HP:0009113)1.48826258
173Generalized tonic-clonic seizures (HP:0002069)1.48686801
174Abnormal EKG (HP:0003115)1.48527556
175Protruding tongue (HP:0010808)1.48413266
176Dysphonia (HP:0001618)1.47612959
177Hyperglycinuria (HP:0003108)1.46729094
178Truncal obesity (HP:0001956)1.45327665
179Myotonia (HP:0002486)1.45127921
180Maternal diabetes (HP:0009800)1.45088878
181Dialeptic seizures (HP:0011146)1.43787506
182J-shaped sella turcica (HP:0002680)1.43341152
183Abnormal respiratory epithelium morphology (HP:0012253)1.42608887
184Abnormal respiratory motile cilium morphology (HP:0005938)1.42608887
185Microglossia (HP:0000171)1.40868554
186Hypoparathyroidism (HP:0000829)1.40758754

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.46482172
2MARK13.29467114
3SIK23.08887915
4FES2.46373947
5NME22.37457418
6EPHA42.29576223
7VRK22.19009120
8PNCK2.17410072
9EEF2K2.17142827
10DYRK22.16742581
11MAP3K92.15166278
12PKN22.12951809
13TYRO32.11158337
14PINK12.09996793
15CDK192.03067275
16SIK12.01373106
17MAP4K11.97892369
18MUSK1.97525755
19OBSCN1.97244888
20RPS6KB21.95423252
21TRIB31.94714831
22DAPK21.93425876
23NTRK21.90274653
24TNIK1.88528309
25TAOK11.80447647
26MARK21.78786543
27NTRK31.78266913
28MAP3K101.74418881
29LATS21.72616300
30CAMKK11.70206997
31TAF11.67230436
32PAK61.60279419
33IRAK31.60269728
34TXK1.52350912
35DYRK31.52264325
36MINK11.46201598
37EPHB11.45028464
38MAP3K71.42803066
39ICK1.37849434
40ALK1.35961776
41INSRR1.32452741
42DMPK1.29496783
43HCK1.21226773
44KSR21.21083248
45RIPK41.20805209
46UHMK11.20084343
47SYK1.14019801
48PHKG11.13388393
49PHKG21.13388393
50RET1.12183314
51CDK51.12043844
52STK111.10605594
53MAP3K131.10354677
54RIPK11.08959441
55PRKCH1.08751580
56MAPK131.08079921
57PDGFRB1.05088599
58TAOK21.03506486
59GRK61.02396809
60FGFR21.02116629
61DAPK11.00632577
62FGFR30.99820004
63PRPF4B0.99677233
64MAP3K40.99524680
65CDK30.98068501
66ZAP700.96722054
67SMG10.96383714
68SCYL20.95903571
69IKBKE0.95848603
70NME10.95751627
71MAPK120.94808710
72KIT0.93771428
73CAMK10.93720615
74CAMK1G0.92717469
75CSNK1G20.92246131
76FGFR40.92240252
77CHEK20.91564141
78RPS6KA20.91326322
79PRKD30.91259754
80PDK10.91087233
81BRAF0.88861577
82PTK60.88013822
83NEK20.85098326
84ITK0.83657884
85CAMKK20.82256535
86ARAF0.81515801
87FYN0.81264866
88NTRK10.80987853
89VRK10.80786840
90MAP2K20.80757630
91PRKCG0.77547955
92PDPK10.76346612
93MTOR0.75994647
94RPS6KB10.74742921
95MAPKAPK50.74536632
96TTN0.74058525
97WNK40.73685049
98CSNK1E0.73634010
99ADRBK20.71149121
100HIPK20.70607877
101KSR10.70369057
102CDC70.70137466
103MAPK40.69207468
104MAP2K40.67938434
105RPS6KC10.67684472
106RPS6KL10.67684472
107PRKG20.67560707
108LCK0.67100819
109CAMK2D0.66945913
110AURKA0.66915636
111PIM20.66795782
112MAPK150.66782899
113JAK10.65916284
114PRKCI0.64664653
115CDK70.64204855
116ILK0.63885448
117RPS6KA60.63658030
118JAK20.63599832
119CAMK2B0.62396830
120PRKD20.62279129
121TYK20.62059148
122CLK10.61387473
123CAMK40.61116007
124DYRK1B0.60935141
125TBK10.58371725
126JAK30.57690529
127BTK0.56860907
128FLT30.56487139
129TIE10.56396908
130CSNK1A1L0.56209018
131RPS6KA10.56131816
132MAPKAPK30.55855033
133CDK140.55795005
134MAP3K110.54751542
135CAMK2G0.54737708
136CHUK0.53779512
137SGK30.53425208
138LRRK20.53065629
139TNK20.52456651
140CDK80.52166330
141PKN10.51627804
142PRKD10.51382399
143AKT20.51015256
144PLK10.50243384
145CSK0.48605970
146RAF10.48318120
147CSNK1G30.47957972
148CSNK1D0.47496131
149TLK10.46081004
150PRKCQ0.44423138
151MAP3K20.43250068
152MAP2K70.43042981
153PAK30.42873860
154CDK180.42748964
155MAP3K10.42085833
156ABL20.41799856
157PRKAA10.41692537
158CDK11A0.41548850
159STK380.41403985
160GSK3B0.40825999
161MAPK80.40034397
162CDK150.37912880
163SRC0.37390978

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.15822445
2Cardiac muscle contraction_Homo sapiens_hsa042602.89030274
3Oxidative phosphorylation_Homo sapiens_hsa001902.51519704
4Parkinsons disease_Homo sapiens_hsa050122.40916138
5Olfactory transduction_Homo sapiens_hsa047402.17585826
6Alzheimers disease_Homo sapiens_hsa050101.89794543
7Primary immunodeficiency_Homo sapiens_hsa053401.86950383
8Huntingtons disease_Homo sapiens_hsa050161.86142684
9T cell receptor signaling pathway_Homo sapiens_hsa046601.81516348
10Vitamin B6 metabolism_Homo sapiens_hsa007501.80042945
11Long-term potentiation_Homo sapiens_hsa047201.79308162
12Circadian entrainment_Homo sapiens_hsa047131.71976442
13Glutamatergic synapse_Homo sapiens_hsa047241.68710717
14Morphine addiction_Homo sapiens_hsa050321.67098111
15Cholinergic synapse_Homo sapiens_hsa047251.64956405
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.61104100
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59930917
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.57614182
19Synaptic vesicle cycle_Homo sapiens_hsa047211.54603650
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.54032761
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.50227601
22Oxytocin signaling pathway_Homo sapiens_hsa049211.46000984
23Gastric acid secretion_Homo sapiens_hsa049711.45168300
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.44624425
25Dopaminergic synapse_Homo sapiens_hsa047281.44518044
26GABAergic synapse_Homo sapiens_hsa047271.41940566
27B cell receptor signaling pathway_Homo sapiens_hsa046621.41153068
28Salivary secretion_Homo sapiens_hsa049701.40129743
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.39597790
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.38667833
31Neurotrophin signaling pathway_Homo sapiens_hsa047221.35042387
32Nicotine addiction_Homo sapiens_hsa050331.34675923
33VEGF signaling pathway_Homo sapiens_hsa043701.33842201
34Glioma_Homo sapiens_hsa052141.33344079
35Osteoclast differentiation_Homo sapiens_hsa043801.30340935
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.30093477
37Amphetamine addiction_Homo sapiens_hsa050311.28203222
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26919040
39Non-small cell lung cancer_Homo sapiens_hsa052231.26796610
40Renin secretion_Homo sapiens_hsa049241.26662460
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.26157137
42Chronic myeloid leukemia_Homo sapiens_hsa052201.24648656
43Platelet activation_Homo sapiens_hsa046111.24100994
44GnRH signaling pathway_Homo sapiens_hsa049121.24054016
45ErbB signaling pathway_Homo sapiens_hsa040121.23160864
46Phospholipase D signaling pathway_Homo sapiens_hsa040721.20732413
47Axon guidance_Homo sapiens_hsa043601.20634378
48Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20370692
49Acute myeloid leukemia_Homo sapiens_hsa052211.19537354
50RNA polymerase_Homo sapiens_hsa030201.18992511
51Type II diabetes mellitus_Homo sapiens_hsa049301.18959314
52Estrogen signaling pathway_Homo sapiens_hsa049151.17396839
53Chemokine signaling pathway_Homo sapiens_hsa040621.15545649
54mRNA surveillance pathway_Homo sapiens_hsa030151.13481822
55Folate biosynthesis_Homo sapiens_hsa007901.12626387
56Cocaine addiction_Homo sapiens_hsa050301.11894263
57Long-term depression_Homo sapiens_hsa047301.10632077
58Gap junction_Homo sapiens_hsa045401.07842816
59Endometrial cancer_Homo sapiens_hsa052131.07302015
60cAMP signaling pathway_Homo sapiens_hsa040241.05670188
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05452637
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04686974
63Dorso-ventral axis formation_Homo sapiens_hsa043201.03766147
64Phototransduction_Homo sapiens_hsa047441.02851518
65Renal cell carcinoma_Homo sapiens_hsa052111.02564235
66Colorectal cancer_Homo sapiens_hsa052101.02133354
67Calcium signaling pathway_Homo sapiens_hsa040201.01563876
68Sulfur relay system_Homo sapiens_hsa041221.00582598
69Steroid biosynthesis_Homo sapiens_hsa001001.00532757
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.97388242
71mTOR signaling pathway_Homo sapiens_hsa041500.96836614
72MAPK signaling pathway_Homo sapiens_hsa040100.95355352
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.95056706
74Glucagon signaling pathway_Homo sapiens_hsa049220.95031510
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94586608
76Choline metabolism in cancer_Homo sapiens_hsa052310.94426718
77Basal transcription factors_Homo sapiens_hsa030220.94269235
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93975678
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93127489
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.89902673
81Spliceosome_Homo sapiens_hsa030400.89846797
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88892784
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87432228
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86921174
85Rap1 signaling pathway_Homo sapiens_hsa040150.86367881
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85945542
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85817093
88Serotonergic synapse_Homo sapiens_hsa047260.85435342
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85133908
90Insulin secretion_Homo sapiens_hsa049110.84772262
91Endocytosis_Homo sapiens_hsa041440.83084191
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81971179
93Melanogenesis_Homo sapiens_hsa049160.81376575
94Leishmaniasis_Homo sapiens_hsa051400.81268791
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80810874
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80417337
97Notch signaling pathway_Homo sapiens_hsa043300.80230253
98Wnt signaling pathway_Homo sapiens_hsa043100.79230100
99Prolactin signaling pathway_Homo sapiens_hsa049170.77995559
100Dilated cardiomyopathy_Homo sapiens_hsa054140.77789504
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77408050
102AMPK signaling pathway_Homo sapiens_hsa041520.76770849
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.76398121
104Pancreatic cancer_Homo sapiens_hsa052120.76064917
105Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75261233
106RNA transport_Homo sapiens_hsa030130.74544323
107Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74279927
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.73274524
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72913996
110Insulin resistance_Homo sapiens_hsa049310.72491525
111Insulin signaling pathway_Homo sapiens_hsa049100.70949916
112Viral myocarditis_Homo sapiens_hsa054160.70944197
113Prion diseases_Homo sapiens_hsa050200.70808984
114Ras signaling pathway_Homo sapiens_hsa040140.70162212
115Melanoma_Homo sapiens_hsa052180.70102480
116Oocyte meiosis_Homo sapiens_hsa041140.69635777
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68624568
118Base excision repair_Homo sapiens_hsa034100.68423430
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68075979
120Butanoate metabolism_Homo sapiens_hsa006500.66567233
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65843824
122RNA degradation_Homo sapiens_hsa030180.65804751
123Maturity onset diabetes of the young_Homo sapiens_hsa049500.65489024
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65336756
125Toxoplasmosis_Homo sapiens_hsa051450.64746945
126Taste transduction_Homo sapiens_hsa047420.64104965
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64038054
128Steroid hormone biosynthesis_Homo sapiens_hsa001400.62718549
129Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61683683
130Basal cell carcinoma_Homo sapiens_hsa052170.61635307
131TNF signaling pathway_Homo sapiens_hsa046680.61565269
132Salmonella infection_Homo sapiens_hsa051320.61092397
133FoxO signaling pathway_Homo sapiens_hsa040680.60579236
134Adipocytokine signaling pathway_Homo sapiens_hsa049200.60408512
135Measles_Homo sapiens_hsa051620.59841871
136Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58970383
137Selenocompound metabolism_Homo sapiens_hsa004500.58122619
138Shigellosis_Homo sapiens_hsa051310.58077617
139Proteoglycans in cancer_Homo sapiens_hsa052050.58052744
140Hepatitis B_Homo sapiens_hsa051610.57461126
141Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57205251
142Chemical carcinogenesis_Homo sapiens_hsa052040.56159474
143Tuberculosis_Homo sapiens_hsa051520.55740614
144Nucleotide excision repair_Homo sapiens_hsa034200.55007599
145Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54161424
146Pyrimidine metabolism_Homo sapiens_hsa002400.54105542
147Thyroid cancer_Homo sapiens_hsa052160.50838080
148Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50150540
149Alcoholism_Homo sapiens_hsa050340.49021639
150Hippo signaling pathway_Homo sapiens_hsa043900.47386951
151Ovarian steroidogenesis_Homo sapiens_hsa049130.46676088
152Cell cycle_Homo sapiens_hsa041100.46636277
153Tight junction_Homo sapiens_hsa045300.44789261
154Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44546955
155Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44277032

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