ZNRF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.85409444
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.85409444
3response to peptidoglycan (GO:0032494)4.55687693
4negative regulation of interleukin-12 production (GO:0032695)4.50338173
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.50186728
6antigen processing and presentation of endogenous antigen (GO:0019883)4.40104775
7macrophage activation involved in immune response (GO:0002281)4.20211173
8positive regulation of gamma-delta T cell activation (GO:0046645)4.00919638
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.95876051
10negative regulation of cell killing (GO:0031342)3.95876051
11regulation of vitamin D biosynthetic process (GO:0060556)3.94315712
12valine metabolic process (GO:0006573)3.91632622
13regulation of T-helper 1 cell differentiation (GO:0045625)3.81726981
14lipopolysaccharide-mediated signaling pathway (GO:0031663)3.79878015
15neutrophil activation involved in immune response (GO:0002283)3.79110205
16regulation of interferon-alpha production (GO:0032647)3.76374130
17detection of molecule of bacterial origin (GO:0032490)3.56386723
18positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.56108671
19type I interferon signaling pathway (GO:0060337)3.55316614
20cellular response to type I interferon (GO:0071357)3.55316614
21response to type I interferon (GO:0034340)3.53069447
22regulation of gamma-delta T cell differentiation (GO:0045586)3.45289418
23immunoglobulin mediated immune response (GO:0016064)3.44444616
24germinal center formation (GO:0002467)3.43129259
25fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.42593694
26T-helper 1 type immune response (GO:0042088)3.41924156
27regulation of vitamin metabolic process (GO:0030656)3.39662038
28detection of other organism (GO:0098543)3.34959051
29low-density lipoprotein particle clearance (GO:0034383)3.33910921
30urea metabolic process (GO:0019627)3.31788423
31urea cycle (GO:0000050)3.31788423
32positive regulation of type 2 immune response (GO:0002830)3.29590110
33cysteine metabolic process (GO:0006534)3.24146944
34positive thymic T cell selection (GO:0045059)3.22392404
35interferon-gamma-mediated signaling pathway (GO:0060333)3.20311652
36interferon-gamma production (GO:0032609)3.17370348
37regulation of cholesterol storage (GO:0010885)3.17079074
38regulation of podosome assembly (GO:0071801)3.14365543
39regulation of gamma-delta T cell activation (GO:0046643)3.13259800
40defense response to protozoan (GO:0042832)3.12468425
41complement activation, alternative pathway (GO:0006957)3.10542663
42alpha-linolenic acid metabolic process (GO:0036109)3.08677848
43detection of external biotic stimulus (GO:0098581)3.05352698
44response to protozoan (GO:0001562)3.04445492
45sulfur amino acid catabolic process (GO:0000098)3.03816256
46production of molecular mediator involved in inflammatory response (GO:0002532)3.01222604
47NIK/NF-kappaB signaling (GO:0038061)2.99758612
48regulation of chronic inflammatory response (GO:0002676)2.98857988
49detection of bacterium (GO:0016045)2.98362615
50regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.97720335
51regulation of hypersensitivity (GO:0002883)2.96149933
52response to muramyl dipeptide (GO:0032495)2.94952211
53peptidyl-glutamic acid carboxylation (GO:0017187)2.94562952
54protein carboxylation (GO:0018214)2.94562952
55regulation of dendritic cell antigen processing and presentation (GO:0002604)2.94522153
56macrophage activation (GO:0042116)2.93850961
57positive regulation of cellular amide metabolic process (GO:0034250)2.93012070
58cellular response to ethanol (GO:0071361)2.92831576
59nitrogen cycle metabolic process (GO:0071941)2.92777634
60regulation of cytokine secretion involved in immune response (GO:0002739)2.89194175
61cellular response to thyroid hormone stimulus (GO:0097067)2.89013104
62aromatic amino acid family catabolic process (GO:0009074)2.88330262
63L-phenylalanine catabolic process (GO:0006559)2.87321791
64erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.87321791
65negative regulation of erythrocyte differentiation (GO:0045647)2.84015684
66glycosphingolipid catabolic process (GO:0046479)2.83852359
67regulation of T-helper 2 cell differentiation (GO:0045628)2.83266284
68granulocyte activation (GO:0036230)2.82852096
69urate metabolic process (GO:0046415)2.82364013
70positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.82334865
71serine family amino acid catabolic process (GO:0009071)2.81832020
72tryptophan catabolic process (GO:0006569)2.81796020
73indole-containing compound catabolic process (GO:0042436)2.81796020
74indolalkylamine catabolic process (GO:0046218)2.81796020
75growth hormone receptor signaling pathway (GO:0060396)2.80625079
76positive regulation of B cell differentiation (GO:0045579)2.80592028
77amino-acid betaine metabolic process (GO:0006577)2.80454735
78negative regulation of cytokine production involved in immune response (GO:0002719)2.80026272
79tryptophan metabolic process (GO:0006568)2.79064982
80positive regulation of interferon-beta production (GO:0032728)2.78944158
81positive regulation of toll-like receptor signaling pathway (GO:0034123)2.77983838
82regulation of interleukin-12 production (GO:0032655)2.77473064
83L-phenylalanine metabolic process (GO:0006558)2.76461834
84erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.76461834
85regulation of mononuclear cell migration (GO:0071675)2.75968492
86JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.75953918
87regulation of sequestering of triglyceride (GO:0010889)2.75426047
88regulation of type I interferon-mediated signaling pathway (GO:0060338)2.74794285
89myeloid cell activation involved in immune response (GO:0002275)2.74544849
90positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.74011947
91drug transmembrane transport (GO:0006855)2.73703749
92response to host immune response (GO:0052572)2.72112532
93response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.72112532
94triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.71538516
95negative regulation of T cell mediated immunity (GO:0002710)2.70873331
96positive regulation of chemokine biosynthetic process (GO:0045080)2.70243561
97regulation of T cell tolerance induction (GO:0002664)2.69272435
98microglial cell activation (GO:0001774)2.69179081
99positive T cell selection (GO:0043368)2.68894804
100detection of biotic stimulus (GO:0009595)2.68462021
101myeloid dendritic cell differentiation (GO:0043011)2.68330520
102regulation of B cell receptor signaling pathway (GO:0050855)2.68307996
103phospholipid homeostasis (GO:0055091)2.67982585
104positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.67353370
105regulation of interleukin-8 biosynthetic process (GO:0045414)2.66708082
106Arp2/3 complex-mediated actin nucleation (GO:0034314)2.66364943
107regulation of fever generation (GO:0031620)2.66232892
108regulation of interferon-beta production (GO:0032648)2.65804627
109positive regulation of heat generation (GO:0031652)2.65154413
110negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.64659506
111B cell mediated immunity (GO:0019724)2.63781980
112hepatocyte apoptotic process (GO:0097284)2.63523889
113negative T cell selection (GO:0043383)2.63189329
114branching involved in labyrinthine layer morphogenesis (GO:0060670)2.63076076
115negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.62676780
116regulation of type 2 immune response (GO:0002828)2.62622754
117oligosaccharide catabolic process (GO:0009313)2.61253109
118negative regulation of lipid storage (GO:0010888)2.61185029
119N-acetylneuraminate metabolic process (GO:0006054)2.61025940
120negative regulation of myeloid cell apoptotic process (GO:0033033)2.60867481
121positive regulation of Cdc42 GTPase activity (GO:0043089)2.60659501
122cellular extravasation (GO:0045123)2.57961988
123positive regulation of NF-kappaB import into nucleus (GO:0042346)2.56680644
124neutrophil activation (GO:0042119)2.56466151
125thymic T cell selection (GO:0045061)2.56157031
126cellular response to lipopolysaccharide (GO:0071222)2.56020179
127glycolipid catabolic process (GO:0019377)2.55979931
128antigen processing and presentation via MHC class Ib (GO:0002475)2.55572813
129regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.55452852
130regulation of tolerance induction (GO:0002643)2.55389184
131cellular response to interferon-gamma (GO:0071346)2.55342765
132cellular response to molecule of bacterial origin (GO:0071219)2.55116630
133regulation of NF-kappaB import into nucleus (GO:0042345)2.54882894
134regulation of mast cell degranulation (GO:0043304)2.54872951
135regulation of B cell differentiation (GO:0045577)2.51728712
136phospholipid efflux (GO:0033700)2.51569622
137negative thymic T cell selection (GO:0045060)2.51462781
138negative regulation of phagocytosis (GO:0050765)2.51376392
139lysine metabolic process (GO:0006553)2.50783616
140lysine catabolic process (GO:0006554)2.50783616
141kynurenine metabolic process (GO:0070189)2.49874719
142fatty acid transmembrane transport (GO:1902001)2.47900754
143regulation of cholesterol homeostasis (GO:2000188)2.47859504
144plasma lipoprotein particle clearance (GO:0034381)2.47435834
145regulation of triglyceride catabolic process (GO:0010896)2.45519042
146regulation of interferon-beta biosynthetic process (GO:0045357)2.45129792
147lipid storage (GO:0019915)2.43405328
148modulation by symbiont of host immune response (GO:0052553)2.43137384
149positive regulation by symbiont of host defense response (GO:0052509)2.43137384
150modulation by symbiont of host defense response (GO:0052031)2.43137384
151modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.43137384
152modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.43137384
153positive regulation by organism of defense response of other organism involved in symbiotic interact2.43137384
154positive regulation of histone deacetylation (GO:0031065)2.42620432
155glyoxylate metabolic process (GO:0046487)2.42036854
156homocysteine metabolic process (GO:0050667)2.41571996
157regulation of protein activation cascade (GO:2000257)2.40626356
158regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.38648323
159positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.38489717
160cellular response to growth hormone stimulus (GO:0071378)2.37466101
1612-oxoglutarate metabolic process (GO:0006103)2.37221491
162regulation of interleukin-12 biosynthetic process (GO:0045075)2.37160425
163carnitine metabolic process (GO:0009437)2.35986213
164response to growth hormone (GO:0060416)2.34936067
165T cell selection (GO:0045058)2.33593866
166drug transport (GO:0015893)2.32556754
167regulation of response to interferon-gamma (GO:0060330)2.32392679
168tricarboxylic acid metabolic process (GO:0072350)2.32368404
169regulation of complement activation (GO:0030449)2.31922882
170drug catabolic process (GO:0042737)2.31814832
171bile acid biosynthetic process (GO:0006699)2.31469572
172positive regulation of interferon-alpha production (GO:0032727)2.29974665
173fatty acid beta-oxidation (GO:0006635)2.29516329
174pinocytosis (GO:0006907)2.28609093
175positive regulation of lipid storage (GO:0010884)2.28085825
176fatty acid oxidation (GO:0019395)2.27922041
177positive regulation of lipid catabolic process (GO:0050996)2.27153041
178positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.23749242
179bile acid metabolic process (GO:0008206)2.23582805
180T cell migration (GO:0072678)2.22111972
181interferon-gamma secretion (GO:0072643)2.21963558

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.19171055
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.04366000
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.46345198
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.25115230
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.21795561
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.16163982
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.89990763
8LXR_22158963_ChIP-Seq_LIVER_Mouse2.82917028
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.73760866
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.67902288
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.55510984
12* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.49706263
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.49262036
14E2F7_22180533_ChIP-Seq_HELA_Human2.46191220
15* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.44114484
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.39929348
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.39698788
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.39370359
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.38574352
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.38179593
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.34885335
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.26411216
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.17925184
24MYC_22102868_ChIP-Seq_BL_Human2.10894810
25GATA1_22025678_ChIP-Seq_K562_Human2.06241672
26* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.05292152
27BRD4_27068464_Chip-Seq_AML-cells_Mouse2.02482421
28FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.00424258
29* MYB_26560356_Chip-Seq_TH2_Human2.00062667
30CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.88698860
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.87734339
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.87272101
33RUNX_20019798_ChIP-Seq_JUKART_Human1.86912992
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.82617237
35MYB_26560356_Chip-Seq_TH1_Human1.79679171
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.78440593
37MAF_26560356_Chip-Seq_TH1_Human1.76487274
38TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70655260
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.70364732
40* TCF7_22412390_ChIP-Seq_EML_Mouse1.69713457
41SCL_19346495_ChIP-Seq_HPC-7_Human1.60672813
42STAT4_19710469_ChIP-ChIP_TH1__Mouse1.58408972
43* UTX_26944678_Chip-Seq_JUKART_Human1.57302684
44SPI1_23547873_ChIP-Seq_NB4_Human1.57262123
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.56435016
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.54407095
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.52426862
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.51119993
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.50742073
50VDR_21846776_ChIP-Seq_THP-1_Human1.49725634
51GATA3_27048872_Chip-Seq_THYMUS_Human1.47404903
52TP63_17297297_ChIP-ChIP_HaCaT_Human1.46499582
53RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.43982413
54FOXM1_23109430_ChIP-Seq_U2OS_Human1.41220001
55* CLOCK_20551151_ChIP-Seq_293T_Human1.40638769
56PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.40101015
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38401057
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38370365
59* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.38152393
60FOXO3_23340844_ChIP-Seq_DLD1_Human1.37200381
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.36315954
62* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.35666600
63PU_27001747_Chip-Seq_BMDM_Mouse1.34287030
64GATA1_19941826_ChIP-Seq_K562_Human1.29006908
65GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28922450
66GATA1_19941827_ChIP-Seq_MEL_Mouse1.27888308
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27748894
68VDR_24763502_ChIP-Seq_THP-1_Human1.27627634
69E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.26982114
70FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.24580311
71NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.21759705
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.20881663
73BP1_19119308_ChIP-ChIP_Hs578T_Human1.19804078
74GATA2_21666600_ChIP-Seq_HMVEC_Human1.16805026
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13942319
76TFEB_21752829_ChIP-Seq_HELA_Human1.12816857
77GATA3_26560356_Chip-Seq_TH2_Human1.12464309
78ESR1_21235772_ChIP-Seq_MCF-7_Human1.11268134
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09950955
80TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.08065095
81TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07614275
82* GATA6_25053715_ChIP-Seq_YYC3_Human1.06862900
83SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05860000
84SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03920647
85MAF_26560356_Chip-Seq_TH2_Human1.02001579
86CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01444301
87* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00101884
88* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00101884
89ESR1_20079471_ChIP-ChIP_T-47D_Human1.00034146
90HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.99111021
91TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.96289390
92* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96065419
93* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95775126
94MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95747184
95KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94978918
96ZNF263_19887448_ChIP-Seq_K562_Human0.94602243
97CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93324668
98SPI1_23127762_ChIP-Seq_K562_Human0.92917411
99SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92915579
100GATA4_25053715_ChIP-Seq_YYC3_Human0.92648980
101* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92348381
102TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92184819
103KDM2B_26808549_Chip-Seq_DND41_Human0.91460914
104FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91021162
105* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90290234
106ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.89927949
107* SOX2_20726797_ChIP-Seq_SW620_Human0.89821220
108SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89550564
109SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89490809
110GATA1_19941827_ChIP-Seq_MEL86_Mouse0.89199611
111TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89052218
112ELK3_25401928_ChIP-Seq_HUVEC_Human0.88979634
113LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.88886103
114PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88654650
115VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.88481437
116* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88090003
117STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86894306
118GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86814381
119NCOR1_26117541_ChIP-Seq_K562_Human0.86191091
120VDR_24787735_ChIP-Seq_THP-1_Human0.84136415
121PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82972166
122GATA2_19941826_ChIP-Seq_K562_Human0.82653726
123FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.82131227
124* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.81264594
125TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.80905325
126LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.80504411
127GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.79829160

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.49931252
2MP0005360_urolithiasis3.36030048
3MP0005365_abnormal_bile_salt2.89465409
4MP0005085_abnormal_gallbladder_physiolo2.44617214
5MP0001835_abnormal_antigen_presentation2.42321709
6MP0004510_myositis2.32791000
7MP0003300_gastrointestinal_ulcer2.29055395
8MP0002138_abnormal_hepatobiliary_system2.21238676
9MP0003191_abnormal_cellular_cholesterol2.18445074
10MP0003436_decreased_susceptibility_to2.13045061
11MP0002166_altered_tumor_susceptibility2.03695448
12MP0003303_peritoneal_inflammation2.03391660
13MP0008004_abnormal_stomach_pH2.02136171
14MP0003252_abnormal_bile_duct2.00361738
15MP0008875_abnormal_xenobiotic_pharmacok1.91830748
16MP0003763_abnormal_thymus_physiology1.90479325
17MP0010329_abnormal_lipoprotein_level1.88589477
18MP0005670_abnormal_white_adipose1.86904847
19MP0005671_abnormal_response_to1.82811554
20MP0004185_abnormal_adipocyte_glucose1.80816518
21MP0002006_tumorigenesis1.74861258
22MP0009840_abnormal_foam_cell1.74568313
23MP0001800_abnormal_humoral_immune1.71940212
24MP0010234_abnormal_vibrissa_follicle1.69407917
25MP0000609_abnormal_liver_physiology1.68718252
26MP0003172_abnormal_lysosome_physiology1.66458584
27MP0005000_abnormal_immune_tolerance1.65273032
28MP0000685_abnormal_immune_system1.63575684
29MP0003724_increased_susceptibility_to1.63091496
30MP0005387_immune_system_phenotype1.61874919
31MP0001790_abnormal_immune_system1.61874919
32MP0004947_skin_inflammation1.57363885
33MP0005666_abnormal_adipose_tissue1.56945862
34MP0005025_abnormal_response_to1.56684903
35MP0005464_abnormal_platelet_physiology1.55357370
36MP0002419_abnormal_innate_immunity1.54910505
37MP0002452_abnormal_antigen_presenting1.54302294
38MP0010352_gastrointestinal_tract_polyps1.53321579
39MP0003075_altered_response_to1.52996061
40MP0002877_abnormal_melanocyte_morpholog1.52610840
41MP0002723_abnormal_immune_serum1.50974884
42MP0002254_reproductive_system_inflammat1.49568121
43MP0009785_altered_susceptibility_to1.48124314
44MP0002998_abnormal_bone_remodeling1.46918542
45MP0009278_abnormal_bone_marrow1.46667787
46MP0006082_CNS_inflammation1.46310688
47MP0001819_abnormal_immune_cell1.45380106
48MP0002420_abnormal_adaptive_immunity1.45279460
49MP0004130_abnormal_muscle_cell1.44935179
50MP0004019_abnormal_vitamin_homeostasis1.40899938
51MP0003656_abnormal_erythrocyte_physiolo1.38650058
52MP0001845_abnormal_inflammatory_respons1.36668357
53MP0003705_abnormal_hypodermis_morpholog1.35599042
54MP0010155_abnormal_intestine_physiology1.34649803
55MP0009643_abnormal_urine_homeostasis1.34534184
56MP0003183_abnormal_peptide_metabolism1.32925072
57MP0003690_abnormal_glial_cell1.31729565
58MP0001666_abnormal_nutrient_absorption1.31181823
59MP0008260_abnormal_autophagy1.30289780
60MP0002398_abnormal_bone_marrow1.29147674
61MP0008469_abnormal_protein_level1.24766580
62MP0000343_altered_response_to1.24323069
63MP0002148_abnormal_hypersensitivity_rea1.23954695
64MP0003828_pulmonary_edema1.23469305
65MP0002396_abnormal_hematopoietic_system1.23105557
66MP0005076_abnormal_cell_differentiation1.22665518
67MP0001853_heart_inflammation1.22323568
68MP0005058_abnormal_lysosome_morphology1.21537802
69MP0000604_amyloidosis1.21048567
70MP0003195_calcinosis1.20826604
71MP0005332_abnormal_amino_acid1.20257400
72MP0005451_abnormal_body_composition1.20207557
73MP0002332_abnormal_exercise_endurance1.19778275
74MP0000716_abnormal_immune_system1.19354216
75MP0002405_respiratory_system_inflammati1.18476390
76MP0002118_abnormal_lipid_homeostasis1.17509142
77MP0000858_altered_metastatic_potential1.17033628
78MP0009333_abnormal_splenocyte_physiolog1.16278669
79MP0005166_decreased_susceptibility_to1.14455790
80MP0005319_abnormal_enzyme/_coenzyme1.14405142
81MP0000689_abnormal_spleen_morphology1.12340269
82MP0002009_preneoplasia1.10714788
83MP0002722_abnormal_immune_system1.10205838
84MP0003186_abnormal_redox_activity1.07618321
85MP0001545_abnormal_hematopoietic_system1.07466948
86MP0005397_hematopoietic_system_phenotyp1.07466948
87MP0003453_abnormal_keratinocyte_physiol1.06957508
88MP0002136_abnormal_kidney_physiology1.06489947
89MP0002796_impaired_skin_barrier1.05828769
90MP0003091_abnormal_cell_migration1.03825771
91MP0004264_abnormal_extraembryonic_tissu1.03812747
92MP0001873_stomach_inflammation1.00880250
93MP0009764_decreased_sensitivity_to1.00441580
94MP0002429_abnormal_blood_cell0.99275137
95MP0010307_abnormal_tumor_latency0.98334303
96MP0006054_spinal_hemorrhage0.97627116
97MP0009763_increased_sensitivity_to0.97049713
98MP0000598_abnormal_liver_morphology0.95083190
99MP0001533_abnormal_skeleton_physiology0.95073470
100MP0001216_abnormal_epidermal_layer0.94267955
101MP0000569_abnormal_digit_pigmentation0.93954850
102MP0001851_eye_inflammation0.93548895
103MP0003448_altered_tumor_morphology0.92724412
104MP0005375_adipose_tissue_phenotype0.92585456
105MP0005334_abnormal_fat_pad0.92475402
106MP0003868_abnormal_feces_composition0.92257060
107MP0002971_abnormal_brown_adipose0.92176436
108MP0003806_abnormal_nucleotide_metabolis0.91802390
109MP0000490_abnormal_crypts_of0.91267459
110MP0005164_abnormal_response_to0.90414140
111MP0005310_abnormal_salivary_gland0.89507754
112MP0000465_gastrointestinal_hemorrhage0.89376902
113MP0000703_abnormal_thymus_morphology0.88998604
114MP0001756_abnormal_urination0.88985034
115MP0004808_abnormal_hematopoietic_stem0.88521172
116MP0005167_abnormal_blood-brain_barrier0.88384993
117MP0010678_abnormal_skin_adnexa0.87901692
118MP0008961_abnormal_basal_metabolism0.86093921
119MP0009115_abnormal_fat_cell0.86027777
120MP0004883_abnormal_blood_vessel0.84635593
121MP0003866_abnormal_defecation0.84283954
122MP0001881_abnormal_mammary_gland0.82430548
123MP0003566_abnormal_cell_adhesion0.82089894
124MP0003045_fibrosis0.76620494
125MP0008057_abnormal_DNA_replication0.76575329
126MP0003221_abnormal_cardiomyocyte_apopto0.76414565
127MP0001663_abnormal_digestive_system0.76316290
128MP0009765_abnormal_xenobiotic_induced0.68733084
129MP0005165_increased_susceptibility_to0.67219607
130MP0004381_abnormal_hair_follicle0.66978892

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)4.77318662
2Abnormality of glycosphingolipid metabolism (HP:0004343)4.77318662
3Abnormality of glycolipid metabolism (HP:0010969)4.77318662
4Optic neuritis (HP:0100653)4.28172169
5Retrobulbar optic neuritis (HP:0100654)4.28172169
6Eczematoid dermatitis (HP:0000976)4.03304409
7Recurrent gram-negative bacterial infections (HP:0005420)3.86224045
8Increased cerebral lipofuscin (HP:0011813)3.65208379
9Myocardial infarction (HP:0001658)3.55458259
10Complement deficiency (HP:0004431)3.37217537
11Stomatitis (HP:0010280)3.33566968
12Intrahepatic cholestasis (HP:0001406)3.24783430
13Xanthomatosis (HP:0000991)3.21206483
14Recurrent bacterial skin infections (HP:0005406)3.20908431
15Loss of speech (HP:0002371)3.20567895
16Keratoconjunctivitis sicca (HP:0001097)3.12894609
17Recurrent abscess formation (HP:0002722)3.11068242
18Abnormality of monocarboxylic acid metabolism (HP:0010996)3.06555765
19Deep venous thrombosis (HP:0002625)3.04398247
20T lymphocytopenia (HP:0005403)3.03592955
21Abnormality of aromatic amino acid family metabolism (HP:0004338)2.99902617
22Increased neuronal autofluorescent lipopigment (HP:0002074)2.93403538
23Pustule (HP:0200039)2.89458832
24Abnormality of T cell number (HP:0011839)2.87891911
25Systemic lupus erythematosus (HP:0002725)2.87873300
26Recurrent fungal infections (HP:0002841)2.81675031
27Epidermoid cyst (HP:0200040)2.81506561
28Hypoglycemic coma (HP:0001325)2.81220095
29Recurrent viral infections (HP:0004429)2.79496790
30Joint hemorrhage (HP:0005261)2.79413187
31Keratoconjunctivitis (HP:0001096)2.76116671
32Abnormality of complement system (HP:0005339)2.74722130
33Gangrene (HP:0100758)2.73366449
34Nasal polyposis (HP:0100582)2.66991052
35Autoimmune hemolytic anemia (HP:0001890)2.66045334
36Abnormality of the common coagulation pathway (HP:0010990)2.65781876
37Hyperglycinuria (HP:0003108)2.63285198
38Abnormality of glutamine family amino acid metabolism (HP:0010902)2.60042378
39Myositis (HP:0100614)2.57570749
40Interstitial pulmonary disease (HP:0006530)2.57134119
41Pulmonary infiltrates (HP:0002113)2.56798180
42Abnormality of purine metabolism (HP:0004352)2.53494499
43Vacuolated lymphocytes (HP:0001922)2.52883597
44Disinhibition (HP:0000734)2.52349016
45IgM deficiency (HP:0002850)2.51393318
46Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.51026524
47Autoimmune thrombocytopenia (HP:0001973)2.50938824
48Purpura (HP:0000979)2.49885370
49Gastrointestinal infarctions (HP:0005244)2.48636850
50Hemoptysis (HP:0002105)2.45505072
51Gingival bleeding (HP:0000225)2.42694703
52Hyperlipoproteinemia (HP:0010980)2.42085788
53Abnormality of T cells (HP:0002843)2.39637606
54Abnormality of the fingertips (HP:0001211)2.36681912
55Arterial thrombosis (HP:0004420)2.36296946
56Abnormality of the vasculature of the conjunctiva (HP:0008054)2.36072097
57Ketosis (HP:0001946)2.35776691
58Hematochezia (HP:0002573)2.34954436
59Increased IgE level (HP:0003212)2.32811592
60Abnormal delayed hypersensitivity skin test (HP:0002963)2.31260326
61Colitis (HP:0002583)2.29008605
62Chronic obstructive pulmonary disease (HP:0006510)2.28790312
63Obstructive lung disease (HP:0006536)2.28790312
64Recurrent skin infections (HP:0001581)2.28500479
65Periodontitis (HP:0000704)2.28094844
66Malnutrition (HP:0004395)2.27284819
67Prolonged partial thromboplastin time (HP:0003645)2.26973109
68Hypobetalipoproteinemia (HP:0003563)2.24826119
69Elevated erythrocyte sedimentation rate (HP:0003565)2.24030601
70Hypoalphalipoproteinemia (HP:0003233)2.23925883
71Increased serum ferritin (HP:0003281)2.23591189
72Abnormality of the nasal mucosa (HP:0000433)2.22742595
73Spontaneous hematomas (HP:0007420)2.22515085
74Abnormality of macrophages (HP:0004311)2.22131310
75Abnormality of nucleobase metabolism (HP:0010932)2.22004750
76Hyperglycemia (HP:0003074)2.20061523
77Inflammation of the large intestine (HP:0002037)2.19226977
78Hypercholesterolemia (HP:0003124)2.18327965
79Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.16793246
80Ketoacidosis (HP:0001993)2.16117682
81Amyloidosis (HP:0011034)2.15788731
82Impaired platelet aggregation (HP:0003540)2.14702716
83Abnormal platelet function (HP:0011869)2.14702716
84Pulmonary embolism (HP:0002204)2.14660656
85Urticaria (HP:0001025)2.14332436
86Hypolipoproteinemia (HP:0010981)2.13013794
87Orchitis (HP:0100796)2.12839636
88Upper motor neuron abnormality (HP:0002127)2.12392661
89Hyperammonemia (HP:0001987)2.12223830
90Abnormal platelet volume (HP:0011876)2.10711240
91Basal ganglia calcification (HP:0002135)2.10638608
92Increased IgM level (HP:0003496)2.09491575
93Urinary glycosaminoglycan excretion (HP:0003541)2.09352596
94Mucopolysacchariduria (HP:0008155)2.09352596
95Abnormality of serine family amino acid metabolism (HP:0010894)2.09169723
96Abnormality of glycine metabolism (HP:0010895)2.09169723
97Fat malabsorption (HP:0002630)2.06212374
98Gingivitis (HP:0000230)2.06155082
99Gastrointestinal inflammation (HP:0004386)2.05400856
100Petechiae (HP:0000967)2.05164676
101Recurrent cutaneous fungal infections (HP:0011370)2.05149766
102Chronic mucocutaneous candidiasis (HP:0002728)2.05149766
103Abnormality of sulfur amino acid metabolism (HP:0004339)2.05137293
104Esophageal varix (HP:0002040)2.05061691
105Glomerulonephritis (HP:0000099)2.03937271
106Abnormality of T cell physiology (HP:0011840)2.03812061
107Neurofibrillary tangles (HP:0002185)2.03764117
108Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.02602921
109Joint swelling (HP:0001386)2.02513546
110Encephalitis (HP:0002383)2.02126806
111Prolonged bleeding time (HP:0003010)2.01931950
112Hepatocellular carcinoma (HP:0001402)2.01312942
113Mediastinal lymphadenopathy (HP:0100721)2.01118930
114Hyperglycinemia (HP:0002154)2.00884613
115Anorexia (HP:0002039)2.00664638
116Chronic otitis media (HP:0000389)2.00426666
117Generalized aminoaciduria (HP:0002909)1.99842231
118Abnormality of fatty-acid metabolism (HP:0004359)1.99640294
119Dysostosis multiplex (HP:0000943)1.99564010
120IgA deficiency (HP:0002720)1.98972401
121Vasculitis (HP:0002633)1.98533044
122Mutism (HP:0002300)1.98109929
123Meningitis (HP:0001287)1.97325431
124Cortical dysplasia (HP:0002539)1.96780368
125Epistaxis (HP:0000421)1.96102370
126Polyneuropathy (HP:0001271)1.95439512
127Increased mean platelet volume (HP:0011877)1.94896132
128Pancreatitis (HP:0001733)1.94698234
129Menorrhagia (HP:0000132)1.94508962
130Thrombocytosis (HP:0001894)1.94374095
131Abnormality of iron homeostasis (HP:0011031)1.93760678
132Thrombophlebitis (HP:0004418)1.91803183
133Cellulitis (HP:0100658)1.91121084
134Abnormality of the intrinsic pathway (HP:0010989)1.90920499
135Gout (HP:0001997)1.90045529
136Chronic diarrhea (HP:0002028)1.89741618
137Abnormality of polysaccharide metabolism (HP:0011012)1.89491482
138Abnormality of glycosaminoglycan metabolism (HP:0004371)1.89491482
139Abnormality of mucopolysaccharide metabolism (HP:0011020)1.89491482
140Abnormality of the prostate (HP:0008775)1.89278919
141Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.83805739
142Apathy (HP:0000741)1.83736376
143Leukocytosis (HP:0001974)1.82441578
144Cerebral inclusion bodies (HP:0100314)1.81720488
145Chest pain (HP:0100749)1.81616691
146Bone pain (HP:0002653)1.81070609
147Slow saccadic eye movements (HP:0000514)1.79812786
148Hypergammaglobulinemia (HP:0010702)1.79808631
149Abnormality of the endocardium (HP:0004306)1.79218129
150Neuronal loss in central nervous system (HP:0002529)1.79139542
151Thin bony cortex (HP:0002753)1.78744940
152Abnormality of the pleura (HP:0002103)1.78500482
153Recurrent bronchitis (HP:0002837)1.78326472
154Vertigo (HP:0002321)1.76816304
155Premature loss of primary teeth (HP:0006323)1.76146877
156Hepatosplenomegaly (HP:0001433)1.74791153

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK32.93609203
2PRPF4B2.91957042
3MAP4K12.91560863
4FGFR42.45196300
5TYK22.36468269
6MAP3K102.32044794
7GRK72.18153599
8STK102.15139177
9FGFR32.13853461
10JAK32.12304048
11TRIB32.11017697
12MATK2.07525614
13PKN22.04719658
14FRK2.04104258
15TXK2.03783254
16ERN12.00248274
17ITK1.91363028
18RIPK11.86249577
19MAP3K141.83843952
20JAK11.82073676
21FGR1.81982173
22ZAP701.81931505
23IRAK31.77501197
24IRAK41.77238749
25ACVR1B1.76850790
26BMPR21.73301209
27TAOK21.61651117
28EEF2K1.61591464
29CAMK1D1.60126048
30TGFBR21.58379926
31LATS11.54313790
32CDK61.50155610
33NEK91.49191743
34GRK61.43634451
35TBK11.41455535
36IRAK11.40592626
37JAK21.38850449
38BLK1.38783673
39TEC1.37872878
40MAP3K31.37450129
41IKBKE1.37358349
42MAP3K11.31654791
43FLT31.31622418
44STK31.30563041
45IRAK21.28157388
46SIK11.26283530
47MST1R1.23147606
48LRRK21.19553743
49INSRR1.19486686
50CSK1.19201718
51MAP2K31.17889196
52PIM11.16867565
53RPS6KA41.16370332
54SCYL21.16182983
55PTK61.15833842
56BTK1.14874655
57KIT1.13026952
58DDR21.11082771
59NLK1.11054908
60NME21.09317133
61STK241.08850673
62MAP3K61.06385188
63CDK121.04105401
64IKBKB1.03545989
65MAP3K20.99955310
66BCKDK0.99872717
67SYK0.97895611
68CDC42BPA0.97416005
69CSF1R0.95633628
70CDK40.95490980
71CHUK0.93188988
72PDPK10.91296295
73LCK0.90892237
74MOS0.87473936
75HIPK20.85500080
76PDK40.83617052
77PDK30.83617052
78CAMK1G0.81898785
79HCK0.81035988
80MARK30.79639370
81CAMKK20.76321095
82MAP3K110.75795407
83CDK90.75291643
84BMX0.72484388
85MST40.71298607
86KSR20.70776850
87NEK20.69716697
88LATS20.69560999
89YES10.68138728
90FGFR20.67169561
91MAPKAPK30.64285244
92MAP3K50.64170069
93MAPK110.63467584
94TAOK10.63224653
95PRKAA20.61456604
96BRD40.61303066
97FES0.59683654
98ICK0.56823305
99MAP3K90.55143342
100STK40.54698235
101EPHA30.54622112
102RPS6KC10.53258184
103RPS6KL10.53258184
104RIPK40.52028135
105TYRO30.51913412
106DYRK1B0.51850930
107GSK3A0.51719903
108SIK30.50872806
109SGK30.50282852
110PDK10.49626981
111LYN0.49343374
112SGK20.47922486
113ABL20.47861999
114RET0.47845873
115MARK20.47412225
116ABL10.47399107
117MAP3K70.47275374
118PRKAA10.45627722
119PDGFRB0.44390440
120DYRK30.43726042
121MAPK70.42766438
122MAP3K80.42716606
123PIK3CG0.42557715
124NUAK10.41238738
125RPS6KB20.40668209
126MAP3K130.40242307
127PRKCQ0.39738700
128EGFR0.39512378
129PDGFRA0.39192131
130MELK0.38699026
131RPS6KA60.38088876
132TRPM70.35948727
133MTOR0.34417622

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.63049313
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.51147912
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.50594934
4Caffeine metabolism_Homo sapiens_hsa002322.05867971
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.00933433
6Complement and coagulation cascades_Homo sapiens_hsa046101.97820118
7Asthma_Homo sapiens_hsa053101.95379632
8Fatty acid degradation_Homo sapiens_hsa000711.94260842
9Autoimmune thyroid disease_Homo sapiens_hsa053201.85995209
10Nitrogen metabolism_Homo sapiens_hsa009101.83793325
11PPAR signaling pathway_Homo sapiens_hsa033201.78265349
12Tryptophan metabolism_Homo sapiens_hsa003801.74330839
13Rheumatoid arthritis_Homo sapiens_hsa053231.74135397
14Antigen processing and presentation_Homo sapiens_hsa046121.72770770
15Malaria_Homo sapiens_hsa051441.72650212
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.69889967
17Arginine biosynthesis_Homo sapiens_hsa002201.69202713
18Leishmaniasis_Homo sapiens_hsa051401.57317930
19Selenocompound metabolism_Homo sapiens_hsa004501.56987819
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.52413436
21Primary immunodeficiency_Homo sapiens_hsa053401.46260223
22Osteoclast differentiation_Homo sapiens_hsa043801.44690760
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.43512641
24Type I diabetes mellitus_Homo sapiens_hsa049401.41520395
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.41418722
26beta-Alanine metabolism_Homo sapiens_hsa004101.40083040
27Peroxisome_Homo sapiens_hsa041461.39998483
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.38310896
29Propanoate metabolism_Homo sapiens_hsa006401.35366251
30African trypanosomiasis_Homo sapiens_hsa051431.31521878
31Salmonella infection_Homo sapiens_hsa051321.25016995
32ABC transporters_Homo sapiens_hsa020101.23599822
33Measles_Homo sapiens_hsa051621.23425305
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.16972771
35Fatty acid metabolism_Homo sapiens_hsa012121.16660164
36Insulin resistance_Homo sapiens_hsa049311.14452872
37Graft-versus-host disease_Homo sapiens_hsa053321.14387183
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.14303216
39B cell receptor signaling pathway_Homo sapiens_hsa046621.12697679
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12281425
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11352538
42Toxoplasmosis_Homo sapiens_hsa051451.09878754
43Toll-like receptor signaling pathway_Homo sapiens_hsa046201.09742705
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07908794
45T cell receptor signaling pathway_Homo sapiens_hsa046601.07084559
46Lysine degradation_Homo sapiens_hsa003101.06055332
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.05494206
48Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05110643
49Histidine metabolism_Homo sapiens_hsa003401.03689788
50Glycosaminoglycan degradation_Homo sapiens_hsa005311.03349777
51Intestinal immune network for IgA production_Homo sapiens_hsa046721.03143980
52Systemic lupus erythematosus_Homo sapiens_hsa053221.00994510
53Butanoate metabolism_Homo sapiens_hsa006500.99559568
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99190117
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.99133630
56Legionellosis_Homo sapiens_hsa051340.97803349
57Phagosome_Homo sapiens_hsa041450.97548631
58VEGF signaling pathway_Homo sapiens_hsa043700.96155334
59Acute myeloid leukemia_Homo sapiens_hsa052210.96096929
60Glycerolipid metabolism_Homo sapiens_hsa005610.95092591
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95001716
62Phenylalanine metabolism_Homo sapiens_hsa003600.93266621
63Non-small cell lung cancer_Homo sapiens_hsa052230.91738453
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91362894
65Tuberculosis_Homo sapiens_hsa051520.89349441
66Amoebiasis_Homo sapiens_hsa051460.87901495
67Fat digestion and absorption_Homo sapiens_hsa049750.87899303
68Retinol metabolism_Homo sapiens_hsa008300.87265772
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86809154
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.86460183
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86420880
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86308429
73Lysosome_Homo sapiens_hsa041420.85965128
74Starch and sucrose metabolism_Homo sapiens_hsa005000.85955627
75Chemical carcinogenesis_Homo sapiens_hsa052040.85139215
76Herpes simplex infection_Homo sapiens_hsa051680.85040407
77Other glycan degradation_Homo sapiens_hsa005110.84767972
78Bladder cancer_Homo sapiens_hsa052190.84416126
79Folate biosynthesis_Homo sapiens_hsa007900.84294354
80Influenza A_Homo sapiens_hsa051640.82719610
81Renal cell carcinoma_Homo sapiens_hsa052110.81977701
82Shigellosis_Homo sapiens_hsa051310.81506606
83Pancreatic cancer_Homo sapiens_hsa052120.80835499
84Platelet activation_Homo sapiens_hsa046110.80620170
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78609140
86Pertussis_Homo sapiens_hsa051330.78369897
87Hematopoietic cell lineage_Homo sapiens_hsa046400.78164531
88Prion diseases_Homo sapiens_hsa050200.77545441
89Fatty acid biosynthesis_Homo sapiens_hsa000610.77155677
90Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75084466
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74494601
92Pentose phosphate pathway_Homo sapiens_hsa000300.74358678
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.73458972
94Sphingolipid metabolism_Homo sapiens_hsa006000.73101577
95Sulfur metabolism_Homo sapiens_hsa009200.72699438
96Type II diabetes mellitus_Homo sapiens_hsa049300.72404484
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.72118604
98Viral myocarditis_Homo sapiens_hsa054160.72028759
99Chronic myeloid leukemia_Homo sapiens_hsa052200.71386684
100Dorso-ventral axis formation_Homo sapiens_hsa043200.70862770
101Hepatitis C_Homo sapiens_hsa051600.70066557
102Viral carcinogenesis_Homo sapiens_hsa052030.69753760
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69389068
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.69284203
105Prolactin signaling pathway_Homo sapiens_hsa049170.68546694
106Apoptosis_Homo sapiens_hsa042100.68152418
107Endometrial cancer_Homo sapiens_hsa052130.66151705
108TNF signaling pathway_Homo sapiens_hsa046680.64626410
109Bile secretion_Homo sapiens_hsa049760.62590886
110Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62123436
111mTOR signaling pathway_Homo sapiens_hsa041500.61762090
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.61211010
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60400809
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59815977
115AMPK signaling pathway_Homo sapiens_hsa041520.58664666
116Tyrosine metabolism_Homo sapiens_hsa003500.57073609
117Hepatitis B_Homo sapiens_hsa051610.55957275
118Vitamin B6 metabolism_Homo sapiens_hsa007500.55639261
119HIF-1 signaling pathway_Homo sapiens_hsa040660.54531356
120Epstein-Barr virus infection_Homo sapiens_hsa051690.54096003
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52855566
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52587492
123Prostate cancer_Homo sapiens_hsa052150.49749849
124FoxO signaling pathway_Homo sapiens_hsa040680.49609013
125Pyruvate metabolism_Homo sapiens_hsa006200.48011621
126Allograft rejection_Homo sapiens_hsa053300.47449411
127HTLV-I infection_Homo sapiens_hsa051660.46201045
128Vitamin digestion and absorption_Homo sapiens_hsa049770.46122772
129Chemokine signaling pathway_Homo sapiens_hsa040620.44525469
130Carbon metabolism_Homo sapiens_hsa012000.44332824
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43667944
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43313999
133Small cell lung cancer_Homo sapiens_hsa052220.42812824
134Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42615902
135Galactose metabolism_Homo sapiens_hsa000520.41527149
136ErbB signaling pathway_Homo sapiens_hsa040120.40726255
137Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40697807
138Phospholipase D signaling pathway_Homo sapiens_hsa040720.40666722
1392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40573732
140Notch signaling pathway_Homo sapiens_hsa043300.38758143
141Choline metabolism in cancer_Homo sapiens_hsa052310.38558633
142GnRH signaling pathway_Homo sapiens_hsa049120.37574907
143Insulin signaling pathway_Homo sapiens_hsa049100.35216309
144Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34882824
145Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33909915
146Endocytosis_Homo sapiens_hsa041440.30481656
147Renin-angiotensin system_Homo sapiens_hsa046140.30180975

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