ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	7.78085043
2	negative regulation of B cell apoptotic process (GO:0002903)	5.82124941
3	daunorubicin metabolic process (GO:0044597)	5.45572221
4	polyketide metabolic process (GO:0030638)	5.45572221
5	doxorubicin metabolic process (GO:0044598)	5.45572221
6	mature B cell differentiation involved in immune response (GO:0002313)	5.02928985
7	regulation of penile erection (GO:0060405)	4.90526686
8	metallo-sulfur cluster assembly (GO:0031163)	4.83349073
9	iron-sulfur cluster assembly (GO:0016226)	4.83349073
10	aminoglycoside antibiotic metabolic process (GO:0030647)	4.80324231
11	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	4.77975592
12	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	4.76184014
13	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.61676198
14	nucleotide salvage (GO:0043173)	4.54300140
15	purine nucleotide salvage (GO:0032261)	4.45740060
16	purine deoxyribonucleotide catabolic process (GO:0009155)	4.38864067
17	hyperosmotic salinity response (GO:0042538)	4.36246353
18	2-deoxyribonucleotide biosynthetic process (GO:0009265)	4.34262238
19	deoxyribose phosphate biosynthetic process (GO:0046385)	4.34262238
20	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	4.32837791
21	deoxyribonucleotide catabolic process (GO:0009264)	4.15301348
22	grooming behavior (GO:0007625)	4.05432591
23	negative regulation of mRNA processing (GO:0050686)	4.00182177
24	deoxyribose phosphate catabolic process (GO:0046386)	3.99424674
25	DNA unwinding involved in DNA replication (GO:0006268)	3.98503458
26	aggressive behavior (GO:0002118)	3.93423359
27	Peyers patch development (GO:0048541)	3.92484835
28	mucosal-associated lymphoid tissue development (GO:0048537)	3.92484835
29	prostanoid biosynthetic process (GO:0046457)	3.80382631
30	prostaglandin biosynthetic process (GO:0001516)	3.80382631
31	pyrimidine nucleotide catabolic process (GO:0006244)	3.76176160
32	2-deoxyribonucleotide metabolic process (GO:0009394)	3.74277377
33	viral mRNA export from host cell nucleus (GO:0046784)	3.67478565
34	positive regulation of prostaglandin secretion (GO:0032308)	3.63386729
35	establishment of integrated proviral latency (GO:0075713)	3.63065875
36	UV protection (GO:0009650)	3.62731602
37	peptidyl-arginine omega-N-methylation (GO:0035247)	3.62287340
38	chaperone mediated protein folding requiring cofactor (GO:0051085)	3.61759502
39	negative regulation of RNA splicing (GO:0033119)	3.58401955
40	negative regulation of release of cytochrome c from mitochondria (GO:0090201)	3.55434845
41	deoxyribose phosphate metabolic process (GO:0019692)	3.48384728
42	GDP-mannose metabolic process (GO:0019673)	3.45951470
43	chaperone-mediated protein transport (GO:0072321)	3.41948806
44	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	3.41850422
45	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.38185182
46	purine nucleobase biosynthetic process (GO:0009113)	3.35919454
47	regulation of mitochondrial translation (GO:0070129)	3.34278423
48	heme biosynthetic process (GO:0006783)	3.28018450
49	purine deoxyribonucleotide metabolic process (GO:0009151)	3.26697041
50	mitochondrial calcium ion transport (GO:0006851)	3.26562161
51	dosage compensation (GO:0007549)	3.26039725
52	G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)	3.23735352
53	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	3.21928327
54	pentose-phosphate shunt (GO:0006098)	3.20982130
55	lipopolysaccharide biosynthetic process (GO:0009103)	3.20937843
56	establishment of viral latency (GO:0019043)	3.20359310
57	rRNA transcription (GO:0009303)	3.19534671
58	negative regulation of mRNA metabolic process (GO:1903312)	3.16400604
59	deoxyribonucleotide biosynthetic process (GO:0009263)	3.15614263
60	regulation of B cell apoptotic process (GO:0002902)	3.15103021
61	DNA ligation (GO:0006266)	3.13625119
62	deoxyribonucleotide metabolic process (GO:0009262)	3.12648771
63	autophagic vacuole fusion (GO:0000046)	3.10441892
64	nucleobase biosynthetic process (GO:0046112)	3.09801342
65	glucose catabolic process (GO:0006007)	3.08692551
66	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.08010496
67	ribosome biogenesis (GO:0042254)	3.07896878
68	transcription from mitochondrial promoter (GO:0006390)	3.07588324
69	galactose catabolic process (GO:0019388)	3.07508479
70	nucleoside diphosphate biosynthetic process (GO:0009133)	3.06296373
71	nucleobase-containing small molecule interconversion (GO:0015949)	3.04446075
72	nucleoside salvage (GO:0043174)	3.02723547
73	branched-chain amino acid catabolic process (GO:0009083)	3.00859338
74	pinocytosis (GO:0006907)	3.00659580
75	histone arginine methylation (GO:0034969)	3.00412745
76	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.99411835
77	pyrimidine nucleoside salvage (GO:0043097)	2.98707844
78	pyrimidine-containing compound salvage (GO:0008655)	2.98707844
79	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.96952178
80	Golgi transport vesicle coating (GO:0048200)	2.95958474
81	COPI coating of Golgi vesicle (GO:0048205)	2.95958474
82	ncRNA 3-end processing (GO:0043628)	2.92067204
83	guanosine-containing compound biosynthetic process (GO:1901070)	2.91612858
84	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.90944144
85	nuclear envelope reassembly (GO:0031468)	2.90420374
86	mitotic nuclear envelope reassembly (GO:0007084)	2.90420374
87	oxidative phosphorylation (GO:0006119)	2.90332062
88	morphogenesis of an epithelial fold (GO:0060571)	2.88389637
89	negative regulation of cell aging (GO:0090344)	2.88013464
90	regulation of mammary gland epithelial cell proliferation (GO:0033599)	2.87190407
91	protoporphyrinogen IX biosynthetic process (GO:0006782)	2.85197525
92	negative regulation of erythrocyte differentiation (GO:0045647)	2.84885618
93	definitive hemopoiesis (GO:0060216)	2.83908532
94	regulation of prostaglandin secretion (GO:0032306)	2.82226565
95	mature B cell differentiation (GO:0002335)	2.77118304
96	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	2.76879124
97	porphyrin-containing compound biosynthetic process (GO:0006779)	2.76827847
98	protein retention in ER lumen (GO:0006621)	2.76228813
99	cellular metabolic compound salvage (GO:0043094)	2.76146041
100	positive regulation of megakaryocyte differentiation (GO:0045654)	2.76106644

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.58546148
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.71947386
3	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.84526619
4	E2F7_22180533_ChIP-Seq_HELA_Human	3.12608986
5	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.93162978
6	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.77299355
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.65909699
8	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.61715240
9	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.53395008
10	VDR_21846776_ChIP-Seq_THP-1_Human	2.52433240
11	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.46163308
12	ZNF263_19887448_ChIP-Seq_K562_Human	2.26915363
13	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.16228691
14	MYC_22102868_ChIP-Seq_BL_Human	2.14111726
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.13890674
16	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	2.02363140
17	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.98693962
18	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.95071671
19	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.90602397
20	XRN2_22483619_ChIP-Seq_HELA_Human	1.90277168
21	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.89565927
22	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.87480952
23	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.85777842
24	GABP_19822575_ChIP-Seq_HepG2_Human	1.81193549
25	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.77420451
26	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.75495143
27	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.74256840
28	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.69538014
29	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.67451901
30	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.67264923
31	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.66682991
32	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.65530017
33	CIITA_25753668_ChIP-Seq_RAJI_Human	1.64108319
34	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.63424955
35	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.62297682
36	LXR_22292898_ChIP-Seq_THP-1_Human	1.61422667
37	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.61213272
38	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.60407600
39	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.60380965
40	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.56866880
41	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.54564962
42	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.49981722
43	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.48921612
44	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.48511516
45	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.46245770
46	P68_20966046_ChIP-Seq_HELA_Human	1.46043134
47	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.46040072
48	KDM5A_27292631_Chip-Seq_BREAST_Human	1.45624438
49	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.40422275
50	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.39756314
51	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.39721731
52	BCL6_27268052_Chip-Seq_Bcells_Human	1.36674416
53	DCP1A_22483619_ChIP-Seq_HELA_Human	1.36393994
54	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.32709367
55	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.32416080
56	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.27512326
57	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.26739797
58	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.26588845
59	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.25379160
60	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.24983145
61	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.24772636
62	SCL_19346495_ChIP-Seq_HPC-7_Human	1.23625207
63	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.23257252
64	FOXP3_21729870_ChIP-Seq_TREG_Human	1.22598817
65	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.22263845
66	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.20745337
67	UTX_26944678_Chip-Seq_JUKART_Human	1.20120128
68	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.18776554
69	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.18238033
70	TTF2_22483619_ChIP-Seq_HELA_Human	1.16726043
71	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.16709366
72	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.14781976
73	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.13535427
74	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.13404421
75	GATA1_22025678_ChIP-Seq_K562_Human	1.13375582
76	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.13198476
77	VDR_24763502_ChIP-Seq_THP-1_Human	1.12684007
78	CTCF_21964334_Chip-Seq_Bcells_Human	1.11648045
79	VDR_23849224_ChIP-Seq_CD4+_Human	1.11217178
80	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.10747035
81	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.10560329
82	BCOR_27268052_Chip-Seq_Bcells_Human	1.10047570
83	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.08937294
84	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.06654805
85	RACK7_27058665_Chip-Seq_MCF-7_Human	1.06292032
86	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.04924263
87	E2F1_20622854_ChIP-Seq_HELA_Human	1.04815708
88	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.03098060
89	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.02479263
90	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.00792690
91	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.00439622
92	MAF_26560356_Chip-Seq_TH2_Human	0.99153717
93	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.98837599
94	CTCF_27219007_Chip-Seq_ERYTHROID_Human	0.98221497
95	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.97916522
96	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.97059912
97	CTCF_21964334_ChIP-Seq_BJAB-B_Human	0.95580186
98	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.95342287
99	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.94260711
100	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.93444436

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009697_abnormal_copulation	4.56614826
2	MP0005451_abnormal_body_composition	4.07292180
3	MP0002396_abnormal_hematopoietic_system	3.56199266
4	MP0009278_abnormal_bone_marrow	3.46229859
5	MP0001545_abnormal_hematopoietic_system	2.85849645
6	MP0005397_hematopoietic_system_phenotyp	2.85849645
7	MP0010094_abnormal_chromosome_stability	2.72816897
8	MP0000465_gastrointestinal_hemorrhage	2.30735772
9	MP0003186_abnormal_redox_activity	2.20700403
10	MP0005645_abnormal_hypothalamus_physiol	2.16047563
11	MP0002822_catalepsy	2.09714594
12	MP0005670_abnormal_white_adipose	2.07772446
13	MP0006036_abnormal_mitochondrial_physio	2.07464764
14	MP0005330_cardiomyopathy	2.07299640
15	MP0002234_abnormal_pharynx_morphology	2.07259807
16	MP0003111_abnormal_nucleus_morphology	2.05173524
17	MP0002132_abnormal_respiratory_system	2.04493797
18	MP0002877_abnormal_melanocyte_morpholog	2.03887281
19	MP0008007_abnormal_cellular_replicative	2.01949467
20	MP0005464_abnormal_platelet_physiology	1.97062316
21	MP0003718_maternal_effect	1.94975875
22	MP0001764_abnormal_homeostasis	1.91299060
23	MP0005646_abnormal_pituitary_gland	1.83492813
24	MP0000566_synostosis	1.78418923
25	MP0008932_abnormal_embryonic_tissue	1.74383282
26	MP0000358_abnormal_cell_content/	1.68802774
27	MP0000462_abnormal_digestive_system	1.62514784
28	MP0003183_abnormal_peptide_metabolism	1.62060972
29	MP0004808_abnormal_hematopoietic_stem	1.59723455
30	MP0001849_ear_inflammation	1.52619102
31	MP0002653_abnormal_ependyma_morphology	1.50208519
32	MP0008058_abnormal_DNA_repair	1.48430735
33	MP0006292_abnormal_olfactory_placode	1.45324456
34	MP0008789_abnormal_olfactory_epithelium	1.44915981
35	MP0000538_abnormal_urinary_bladder	1.40660257
36	MP0004147_increased_porphyrin_level	1.40221737
37	MP0005084_abnormal_gallbladder_morpholo	1.40073281
38	MP0002019_abnormal_tumor_incidence	1.30796538
39	MP0010030_abnormal_orbit_morphology	1.29182733
40	MP0000003_abnormal_adipose_tissue	1.22873406
41	MP0005165_increased_susceptibility_to	1.18954683
42	MP0002249_abnormal_larynx_morphology	1.18007217
43	MP0003786_premature_aging	1.17666339
44	MP0003656_abnormal_erythrocyte_physiolo	1.17365954
45	MP0000490_abnormal_crypts_of	1.17100024
46	MP0005501_abnormal_skin_physiology	1.16639127
47	MP0003315_abnormal_perineum_morphology	1.14926247
48	MP0001881_abnormal_mammary_gland	1.14724609
49	MP0008875_abnormal_xenobiotic_pharmacok	1.13479221
50	MP0001664_abnormal_digestion	1.12031656
51	MP0003077_abnormal_cell_cycle	1.10221346
52	MP0003075_altered_response_to	1.09379123
53	MP0001529_abnormal_vocalization	1.09348371
54	MP0005499_abnormal_olfactory_system	1.09041664
55	MP0005394_taste/olfaction_phenotype	1.09041664
56	MP0000681_abnormal_thyroid_gland	1.08186217
57	MP0000751_myopathy	1.04283489
58	MP0010368_abnormal_lymphatic_system	1.01056301
59	MP0003172_abnormal_lysosome_physiology	1.00493351
60	MP0004233_abnormal_muscle_weight	0.99439124
61	MP0000313_abnormal_cell_death	0.99006636
62	MP0004957_abnormal_blastocyst_morpholog	0.97484130
63	MP0000350_abnormal_cell_proliferation	0.97073809
64	MP0006035_abnormal_mitochondrial_morpho	0.96094909
65	MP0005384_cellular_phenotype	0.95437941
66	MP0005666_abnormal_adipose_tissue	0.93672628
67	MP0002080_prenatal_lethality	0.90941702
68	MP0000759_abnormal_skeletal_muscle	0.90906190
69	MP0005375_adipose_tissue_phenotype	0.89568294
70	MP0001905_abnormal_dopamine_level	0.89483143
71	MP0010386_abnormal_urinary_bladder	0.86427846
72	MP0002970_abnormal_white_adipose	0.85508815
73	MP0005621_abnormal_cell_physiology	0.83881013
74	MP0005220_abnormal_exocrine_pancreas	0.82384356
75	MP0005083_abnormal_biliary_tract	0.78371117
76	MP0004782_abnormal_surfactant_physiolog	0.78097187
77	MP0002098_abnormal_vibrissa_morphology	0.77929939
78	MP0001730_embryonic_growth_arrest	0.76473826
79	MP0000858_altered_metastatic_potential	0.75673743
80	MP0002398_abnormal_bone_marrow	0.75053959
81	MP0000678_abnormal_parathyroid_gland	0.74881642
82	MP0004858_abnormal_nervous_system	0.74572475
83	MP0009931_abnormal_skin_appearance	0.73776650
84	MP0003693_abnormal_embryo_hatching	0.73584804
85	MP0002722_abnormal_immune_system	0.73137023
86	MP0008770_decreased_survivor_rate	0.72963333
87	MP0002160_abnormal_reproductive_system	0.72557180
88	MP0000749_muscle_degeneration	0.71968339
89	MP0004185_abnormal_adipocyte_glucose	0.71813801
90	MP0005334_abnormal_fat_pad	0.70990617
91	MP0006276_abnormal_autonomic_nervous	0.70556291
92	MP0001835_abnormal_antigen_presentation	0.70124103
93	MP0000750_abnormal_muscle_regeneration	0.69920757
94	MP0002429_abnormal_blood_cell	0.66312039
95	MP0009333_abnormal_splenocyte_physiolog	0.65347972
96	MP0003763_abnormal_thymus_physiology	0.63868380
97	MP0005376_homeostasis/metabolism_phenot	0.63180478
98	MP0003948_abnormal_gas_homeostasis	0.61603875
99	MP0005075_abnormal_melanosome_morpholog	0.61357822
100	MP0000516_abnormal_urinary_system	0.60459983

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Agammaglobulinemia (HP:0004432)	4.28947287
2	Abnormal mitochondria in muscle tissue (HP:0008316)	3.72098510
3	B lymphocytopenia (HP:0010976)	3.59090923
4	Abnormality of B cell number (HP:0010975)	3.43873988
5	Increased muscle lipid content (HP:0009058)	3.38656273
6	Hypertensive crisis (HP:0100735)	3.33097569
7	Acute necrotizing encephalopathy (HP:0006965)	3.25723615
8	Hydroureter (HP:0000072)	3.23944600
9	Progressive muscle weakness (HP:0003323)	3.20866600
10	Type I transferrin isoform profile (HP:0003642)	3.17567370
11	Cellulitis (HP:0100658)	3.13431376
12	Abnormality of the heme biosynthetic pathway (HP:0010472)	3.11910250
13	Mitochondrial inheritance (HP:0001427)	3.10972782
14	Opisthotonus (HP:0002179)	3.07018281
15	Urethral obstruction (HP:0000796)	3.05089464
16	Acute encephalopathy (HP:0006846)	3.04132755
17	Increased intramyocellular lipid droplets (HP:0012240)	3.02835090
18	Cerebral edema (HP:0002181)	3.02031565
19	Severe combined immunodeficiency (HP:0004430)	3.01693278
20	Acute lymphatic leukemia (HP:0006721)	2.99898007
21	Hepatocellular necrosis (HP:0001404)	2.99616922
22	Exercise intolerance (HP:0003546)	2.97893920
23	Progressive external ophthalmoplegia (HP:0000590)	2.94408319
24	Multiple enchondromatosis (HP:0005701)	2.92774823
25	Ragged-red muscle fibers (HP:0003200)	2.83705120
26	Dicarboxylic aciduria (HP:0003215)	2.82234542
27	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.82234542
28	Increased CSF lactate (HP:0002490)	2.80493085
29	Easy fatigability (HP:0003388)	2.79057992
30	Abnormality of the columella (HP:0009929)	2.73871775
31	Microvesicular hepatic steatosis (HP:0001414)	2.71000201
32	Centrally nucleated skeletal muscle fibers (HP:0003687)	2.67111002
33	Progressive microcephaly (HP:0000253)	2.66269414
34	Aplasia/Hypoplasia of the thymus (HP:0010515)	2.65441127
35	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.61270900
36	Truncus arteriosus (HP:0001660)	2.60950482
37	High anterior hairline (HP:0009890)	2.53787168
38	Hepatic necrosis (HP:0002605)	2.53158698
39	Granulocytopenia (HP:0001913)	2.52447409
40	Degeneration of anterior horn cells (HP:0002398)	2.50151556
41	Abnormality of the anterior horn cell (HP:0006802)	2.50151556
42	Rhabdomyolysis (HP:0003201)	2.50049182
43	Trismus (HP:0000211)	2.48550684
44	Microretrognathia (HP:0000308)	2.48263360
45	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.45386474
46	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.45386474
47	Emotional lability (HP:0000712)	2.39930771
48	Petechiae (HP:0000967)	2.37569990
49	Increased IgE level (HP:0003212)	2.37499088
50	Abnormal protein glycosylation (HP:0012346)	2.35249900
51	Abnormal glycosylation (HP:0012345)	2.35249900
52	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.35249900
53	Abnormal protein N-linked glycosylation (HP:0012347)	2.35249900
54	Lactic acidosis (HP:0003128)	2.34396099
55	Stridor (HP:0010307)	2.32613021
56	Testicular atrophy (HP:0000029)	2.29196619
57	Hyperglycinemia (HP:0002154)	2.28219802
58	Hyperthyroidism (HP:0000836)	2.27170511
59	Respiratory failure (HP:0002878)	2.26899690
60	Distal lower limb amyotrophy (HP:0008944)	2.26472139
61	Progressive macrocephaly (HP:0004481)	2.25217933
62	Abnormal pupillary function (HP:0007686)	2.24548773
63	Lethargy (HP:0001254)	2.23403201
64	Muscle fiber atrophy (HP:0100295)	2.22203297
65	Death in childhood (HP:0003819)	2.22001952
66	Cerebral palsy (HP:0100021)	2.20429676
67	External ophthalmoplegia (HP:0000544)	2.17864900
68	Orthostatic hypotension (HP:0001278)	2.17707726
69	Combined immunodeficiency (HP:0005387)	2.16926826
70	Xerostomia (HP:0000217)	2.15800415
71	Cupped ribs (HP:0000887)	2.11361998
72	Thrombocytosis (HP:0001894)	2.11151288
73	Reticulocytosis (HP:0001923)	2.08687869
74	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.08596817
75	Fragile skin (HP:0001030)	2.05461466
76	Abnormality of the umbilical cord (HP:0010881)	2.02407517
77	Brushfield spots (HP:0001088)	2.00399923
78	Lipid accumulation in hepatocytes (HP:0006561)	1.99318906
79	Joint stiffness (HP:0001387)	1.98651121
80	J-shaped sella turcica (HP:0002680)	1.98081949
81	Autoimmune hemolytic anemia (HP:0001890)	1.97050342
82	Increased serum lactate (HP:0002151)	1.96826051
83	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.96546946
84	Hyperammonemia (HP:0001987)	1.95834889
85	Hepatosplenomegaly (HP:0001433)	1.94279038
86	Mesangial abnormality (HP:0001966)	1.93891237
87	Autoimmune thrombocytopenia (HP:0001973)	1.92265067
88	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	1.92081901
89	Retinal dysplasia (HP:0007973)	1.90492745
90	Hypoparathyroidism (HP:0000829)	1.90287221
91	Seborrheic dermatitis (HP:0001051)	1.89502803
92	Abnormality of reticulocytes (HP:0004312)	1.85485614
93	Abnormality of the tricuspid valve (HP:0001702)	1.85103455
94	Broad distal phalanx of finger (HP:0009836)	1.84720474
95	Sepsis (HP:0100806)	1.82671975
96	Reduced antithrombin III activity (HP:0001976)	1.82080674
97	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.81872392
98	Aplastic anemia (HP:0001915)	1.81304218
99	11 pairs of ribs (HP:0000878)	1.80313491
100	Panhypogammaglobulinemia (HP:0003139)	1.78958086

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	6.28938055
2	SCYL2	5.44252959
3	VRK2	4.93540773
4	KDR	4.40231306
5	TESK2	4.36179944
6	TESK1	3.07067923
7	NME2	2.77472074
8	PIM2	2.53666936
9	PBK	2.51649055
10	FLT3	2.48004807
11	ERN1	2.36710717
12	NUAK1	2.36650983
13	IRAK3	2.13664145
14	MST1R	2.01055128
15	LIMK1	1.87262069
16	MAP3K11	1.61588525
17	IRAK2	1.51116369
18	SIK1	1.44204588
19	VRK1	1.41667787
20	SMG1	1.32978576
21	CDK19	1.20455183
22	ABL2	1.17584741
23	EPHA2	1.15590182
24	TBK1	1.12959168
25	KIT	1.02582385
26	TAOK1	1.00082827
27	TAOK3	0.95398114
28	DAPK1	0.87737268
29	EIF2AK1	0.86138436
30	AURKA	0.84978995
31	MET	0.83723571
32	RAF1	0.83382133
33	CHEK2	0.83230433
34	STK16	0.82780375
35	CDK7	0.82048547
36	ZAK	0.79261962
37	TIE1	0.72716871
38	RPS6KB2	0.70485511
39	GRK6	0.68364334
40	ATR	0.67968288
41	RPS6KA4	0.66842757
42	TTN	0.64070757
43	MAP4K2	0.63891807
44	PAK4	0.63154462
45	CSF1R	0.62525222
46	AURKB	0.60971509
47	TAOK2	0.60527715
48	PKN2	0.55493795
49	PIK3CG	0.52809825
50	BMX	0.51640587
51	CDK4	0.50183547
52	MAP4K1	0.48740551
53	CSNK1G3	0.47791463
54	PAK2	0.46899087
55	CDK9	0.46243829
56	TRIB3	0.45533877
57	ARAF	0.45049208
58	CDC7	0.44705183
59	AKT2	0.43486620
60	DYRK2	0.42769986
61	IKBKB	0.41371489
62	RPS6KA5	0.40905079
63	PRKD2	0.37515271
64	MAP2K7	0.37267090
65	MAP2K2	0.37071058
66	CCNB1	0.36837171
67	TAF1	0.35911663
68	MAP3K1	0.35124724
69	MAPKAPK2	0.34352579
70	CAMK2G	0.33578921
71	CHEK1	0.32913224
72	DAPK3	0.32786829
73	NEK1	0.32559971
74	MOS	0.32009651
75	CLK1	0.31972041
76	RET	0.31911728
77	GRK7	0.31365193
78	GRK5	0.31254253
79	EIF2AK2	0.30974070
80	CSNK2A2	0.28719020
81	CSNK1A1L	0.28530556
82	MATK	0.28259189
83	CDK8	0.28175055
84	LMTK2	0.28121047
85	CSNK1G1	0.27811137
86	MAPK11	0.27091973
87	MAPKAPK5	0.26162233
88	MAP3K6	0.25049235
89	GSK3A	0.23878675
90	PRKD1	0.23873222
91	PAK1	0.23690003
92	LRRK2	0.23558093
93	DYRK3	0.23498701
94	MKNK1	0.23050655
95	MAP3K8	0.22968763
96	PRKCI	0.22847703
97	MTOR	0.22469872
98	CDK11A	0.22076539
99	CDK2	0.21649861
100	MUSK	0.21390024

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	3.96485745
2	Sulfur relay system_Homo sapiens_hsa04122	3.72106117
3	Base excision repair_Homo sapiens_hsa03410	3.15274620
4	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	3.13935981
5	Pyrimidine metabolism_Homo sapiens_hsa00240	2.79517937
6	Proteasome_Homo sapiens_hsa03050	2.37422293
7	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.33853299
8	Homologous recombination_Homo sapiens_hsa03440	2.25986865
9	Mismatch repair_Homo sapiens_hsa03430	2.23984426
10	Spliceosome_Homo sapiens_hsa03040	2.22464153
11	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	2.19406339
12	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.17383199
13	Carbon metabolism_Homo sapiens_hsa01200	2.08213172
14	Primary immunodeficiency_Homo sapiens_hsa05340	1.95938227
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.95462169
16	Parkinsons disease_Homo sapiens_hsa05012	1.93008737
17	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.88854115
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.86594772
19	Ribosome_Homo sapiens_hsa03010	1.86440022
20	RNA polymerase_Homo sapiens_hsa03020	1.84446753
21	Oxidative phosphorylation_Homo sapiens_hsa00190	1.83323837
22	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.80614292
23	Fatty acid elongation_Homo sapiens_hsa00062	1.80542441
24	Nucleotide excision repair_Homo sapiens_hsa03420	1.67121370
25	Pentose phosphate pathway_Homo sapiens_hsa00030	1.66936420
26	Glutathione metabolism_Homo sapiens_hsa00480	1.66923887
27	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.61229876
28	One carbon pool by folate_Homo sapiens_hsa00670	1.59821059
29	Phenylalanine metabolism_Homo sapiens_hsa00360	1.58997441
30	Non-homologous end-joining_Homo sapiens_hsa03450	1.58429742
31	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.51156603
32	Purine metabolism_Homo sapiens_hsa00230	1.47831349
33	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.46395651
34	Bladder cancer_Homo sapiens_hsa05219	1.44083242
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.40928953
36	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.37496720
37	Huntingtons disease_Homo sapiens_hsa05016	1.35470541
38	Galactose metabolism_Homo sapiens_hsa00052	1.25192864
39	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.17446301
40	Tyrosine metabolism_Homo sapiens_hsa00350	1.12969631
41	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.12663588
42	Peroxisome_Homo sapiens_hsa04146	1.11322283
43	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.10280417
44	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.06852254
45	Sulfur metabolism_Homo sapiens_hsa00920	1.00968578
46	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.00429843
47	RNA transport_Homo sapiens_hsa03013	1.00321629
48	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.96070278
49	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.93656539
50	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.92469845
51	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.91202566
52	Fatty acid metabolism_Homo sapiens_hsa01212	0.89959715
53	Shigellosis_Homo sapiens_hsa05131	0.89331334
54	Alzheimers disease_Homo sapiens_hsa05010	0.88435252
55	Butanoate metabolism_Homo sapiens_hsa00650	0.87121940
56	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.86355514
57	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.85541850
58	Metabolic pathways_Homo sapiens_hsa01100	0.83269964
59	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.79235791
60	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.78602033
61	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.75753397
62	Acute myeloid leukemia_Homo sapiens_hsa05221	0.75418630
63	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.73169287
64	Selenocompound metabolism_Homo sapiens_hsa00450	0.72914618
65	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.68012137
66	Salmonella infection_Homo sapiens_hsa05132	0.67269197
67	mRNA surveillance pathway_Homo sapiens_hsa03015	0.66620055
68	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.59634477
69	Pyruvate metabolism_Homo sapiens_hsa00620	0.57750941
70	RNA degradation_Homo sapiens_hsa03018	0.52758690
71	Cell cycle_Homo sapiens_hsa04110	0.51424786
72	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.50646330
73	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.49837242
74	Pancreatic cancer_Homo sapiens_hsa05212	0.49559030
75	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.47522846
76	Folate biosynthesis_Homo sapiens_hsa00790	0.47215229
77	Propanoate metabolism_Homo sapiens_hsa00640	0.44543993
78	Cardiac muscle contraction_Homo sapiens_hsa04260	0.42821769
79	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.42723514
80	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.39732357
81	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.38478400
82	Fatty acid degradation_Homo sapiens_hsa00071	0.37758593
83	Herpes simplex infection_Homo sapiens_hsa05168	0.31572141
84	Vibrio cholerae infection_Homo sapiens_hsa05110	0.29609648
85	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.28810919
86	Viral myocarditis_Homo sapiens_hsa05416	0.27302696
87	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.25288801
88	Alcoholism_Homo sapiens_hsa05034	0.25044984
89	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.24885120
90	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.24533282
91	Non-small cell lung cancer_Homo sapiens_hsa05223	0.24373154
92	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.24015997
93	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.22418465
94	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.20049653
95	Apoptosis_Homo sapiens_hsa04210	0.19420249
96	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.19271116
97	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.17679761
98	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.15633534
99	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.14407149
100	Pertussis_Homo sapiens_hsa05133	0.13913844

ZNRF2P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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