ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein-DNA complex disassembly (GO:0032986)	5.57578413
2	nucleosome disassembly (GO:0006337)	5.57578413
3	positive regulation of catecholamine secretion (GO:0033605)	5.00817224
4	regulation of oxidative stress-induced neuron death (GO:1903203)	4.98327319
5	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	4.81794228
6	gonadal mesoderm development (GO:0007506)	4.70604669
7	dosage compensation (GO:0007549)	4.43652117
8	spermatid nucleus differentiation (GO:0007289)	4.36222119
9	mRNA cleavage (GO:0006379)	4.32787994
10	regulation of phosphoprotein phosphatase activity (GO:0043666)	4.22099506
11	DNA double-strand break processing (GO:0000729)	3.89359521
12	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	3.77954400
13	mitotic chromosome condensation (GO:0007076)	3.76299832
14	relaxation of smooth muscle (GO:0044557)	3.75065259
15	peptidyl-arginine omega-N-methylation (GO:0035247)	3.72095061
16	negative regulation of hydrogen peroxide-induced cell death (GO:1903206)	3.69768714
17	definitive hemopoiesis (GO:0060216)	3.68325491
18	activation of protein kinase B activity (GO:0032148)	3.66300590
19	poly(A)+ mRNA export from nucleus (GO:0016973)	3.61068287
20	DNA topological change (GO:0006265)	3.51512518
21	heterochromatin organization (GO:0070828)	3.50630641
22	acrosome reaction (GO:0007340)	3.40722761
23	motile cilium assembly (GO:0044458)	3.39847046
24	peptidyl-arginine methylation (GO:0018216)	3.39807599
25	peptidyl-arginine N-methylation (GO:0035246)	3.39807599
26	spermatid development (GO:0007286)	3.37630165
27	regulation of oxidative phosphorylation (GO:0002082)	3.36185053
28	AMP metabolic process (GO:0046033)	3.35350571
29	binding of sperm to zona pellucida (GO:0007339)	3.32229339
30	3-UTR-mediated mRNA stabilization (GO:0070935)	3.29222378
31	regulation of vacuole organization (GO:0044088)	3.29127864
32	negative regulation of response to reactive oxygen species (GO:1901032)	3.27408179
33	UV protection (GO:0009650)	3.26754008
34	regulation of autophagic vacuole assembly (GO:2000785)	3.25919269
35	regulation of hydrogen peroxide-induced cell death (GO:1903205)	3.24413649
36	nucleoside diphosphate biosynthetic process (GO:0009133)	3.22084785
37	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.18999030
38	Golgi transport vesicle coating (GO:0048200)	3.09814667
39	COPI coating of Golgi vesicle (GO:0048205)	3.09814667
40	mitochondrion degradation (GO:0000422)	3.09494195
41	regulation of translational fidelity (GO:0006450)	3.07349473
42	ribosome assembly (GO:0042255)	3.06989702
43	DNA unwinding involved in DNA replication (GO:0006268)	3.06793518
44	regulation of cellular respiration (GO:0043457)	3.06171231
45	nucleobase-containing small molecule interconversion (GO:0015949)	3.05060324
46	coenzyme catabolic process (GO:0009109)	3.04344875
47	TOR signaling (GO:0031929)	2.99512362
48	response to muscle activity (GO:0014850)	2.99445367
49	muscle cell cellular homeostasis (GO:0046716)	2.93369900
50	thyroid gland development (GO:0030878)	2.89496208
51	chromosome condensation (GO:0030261)	2.85786714
52	ventricular system development (GO:0021591)	2.84041181
53	negative regulation of cell cycle G2/M phase transition (GO:1902750)	2.83821369
54	protein retention in ER lumen (GO:0006621)	2.83677712
55	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.83140059
56	microtubule severing (GO:0051013)	2.81925102
57	negative regulation of translational initiation (GO:0045947)	2.79399994
58	RNA localization (GO:0006403)	2.79228612
59	potassium ion export (GO:0071435)	2.78031203
60	DNA replication initiation (GO:0006270)	2.77261236
61	protein complex localization (GO:0031503)	2.75942087
62	peptidyl-lysine dimethylation (GO:0018027)	2.75134688
63	negative regulation of defense response to virus (GO:0050687)	2.68498304
64	nucleosome assembly (GO:0006334)	2.66609098
65	histone arginine methylation (GO:0034969)	2.65074272
66	negative regulation of striated muscle cell apoptotic process (GO:0010664)	2.64679479
67	androgen biosynthetic process (GO:0006702)	2.63533586
68	sperm motility (GO:0030317)	2.62620352
69	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)	2.62432716
70	hematopoietic stem cell differentiation (GO:0060218)	2.61748187
71	telomere organization (GO:0032200)	2.61249700
72	DNA strand elongation involved in DNA replication (GO:0006271)	2.57944080
73	nucleosome organization (GO:0034728)	2.57611274
74	telomere maintenance (GO:0000723)	2.56027800
75	muscle filament sliding (GO:0030049)	2.53711368
76	actin-myosin filament sliding (GO:0033275)	2.53711368
77	glycogen metabolic process (GO:0005977)	2.52595230
78	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	2.52517249
79	myofibril assembly (GO:0030239)	2.51687402
80	glutamine family amino acid catabolic process (GO:0009065)	2.51420681
81	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.51256358
82	pentose-phosphate shunt (GO:0006098)	2.51125094
83	ADP metabolic process (GO:0046031)	2.50741529
84	regulation of dopamine secretion (GO:0014059)	2.50470471
85	histone exchange (GO:0043486)	2.49843543
86	protein localization to cell surface (GO:0034394)	2.49509145
87	sister chromatid segregation (GO:0000819)	2.49486459
88	endothelium development (GO:0003158)	2.48306465
89	telomere maintenance via semi-conservative replication (GO:0032201)	2.47388091
90	rRNA transcription (GO:0009303)	2.47093481
91	ATP-dependent chromatin remodeling (GO:0043044)	2.45836027
92	DNA strand elongation (GO:0022616)	2.45515539
93	glucan metabolic process (GO:0044042)	2.45371422
94	cellular glucan metabolic process (GO:0006073)	2.45371422
95	negative regulation of JNK cascade (GO:0046329)	2.43853008
96	negative regulation of microtubule polymerization (GO:0031115)	2.42934220
97	regulation of translational elongation (GO:0006448)	2.42347910
98	negative regulation of cell cycle arrest (GO:0071157)	2.40908657
99	protein-DNA complex assembly (GO:0065004)	2.40627316
100	protein localization to chromosome (GO:0034502)	2.39712573

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	6.68664968
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.66267618
3	FOXM1_23109430_ChIP-Seq_U2OS_Human	4.04754048
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.85466421
5	ZNF263_19887448_ChIP-Seq_K562_Human	3.55719376
6	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.37920850
7	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	3.14670299
8	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.08694681
9	AR_21909140_ChIP-Seq_LNCAP_Human	2.75651341
10	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.68585326
11	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.60524576
12	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.46217051
13	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.43661038
14	ESR1_15608294_ChIP-ChIP_MCF-7_Human	2.42822784
15	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.10113772
16	IGF1R_20145208_ChIP-Seq_DFB_Human	2.08325257
17	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	2.04966288
18	SCL_19346495_ChIP-Seq_HPC-7_Human	1.98458095
19	VDR_21846776_ChIP-Seq_THP-1_Human	1.92438381
20	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.91694243
21	DCP1A_22483619_ChIP-Seq_HELA_Human	1.87714695
22	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.80505887
23	GABP_19822575_ChIP-Seq_HepG2_Human	1.75938388
24	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.74989931
25	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.74846832
26	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.71305030
27	CIITA_25753668_ChIP-Seq_RAJI_Human	1.68365739
28	KDM5A_27292631_Chip-Seq_BREAST_Human	1.65070720
29	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.63521270
30	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.56422137
31	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.56338022
32	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.56336557
33	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.55099809
34	GATA1_22025678_ChIP-Seq_K562_Human	1.54754420
35	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.53368172
36	XRN2_22483619_ChIP-Seq_HELA_Human	1.53150364
37	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.52286358
38	MYC_22102868_ChIP-Seq_BL_Human	1.50751649
39	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.47435558
40	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.47093538
41	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.43205362
42	LXR_22292898_ChIP-Seq_THP-1_Human	1.42234546
43	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.40790881
44	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.40735599
45	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.36467081
46	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.35381182
47	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.34012752
48	KDM2B_26808549_Chip-Seq_DND41_Human	1.31443083
49	CTCF_21964334_Chip-Seq_Bcells_Human	1.31072962
50	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.30784593
51	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.30413477
52	CHD1_26751641_Chip-Seq_LNCaP_Human	1.28985795
53	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.28860333
54	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.27609232
55	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.26302194
56	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.26127440
57	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.26055787
58	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.24691484
59	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.24611311
60	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.19274286
61	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.16559891
62	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.16291168
63	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.14660471
64	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.13837516
65	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.13013228
66	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.12490524
67	NCOR1_26117541_ChIP-Seq_K562_Human	1.11592981
68	RAC3_21632823_ChIP-Seq_H3396_Human	1.09508959
69	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.09334585
70	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.09158894
71	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.06720190
72	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.06641063
73	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.05714935
74	TP53_22127205_ChIP-Seq_IMR90_Human	1.04897421
75	P68_20966046_ChIP-Seq_HELA_Human	1.04825882
76	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.04522021
77	SMC4_20622854_ChIP-Seq_HELA_Human	1.03653374
78	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.02745386
79	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.02387486
80	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.01702387
81	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.01502751
82	RACK7_27058665_Chip-Seq_MCF-7_Human	0.99504617
83	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	0.99089762
84	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.98368290
85	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	0.97191362
86	TTF2_22483619_ChIP-Seq_HELA_Human	0.95548324
87	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.94130087
88	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.94128824
89	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.93809175
90	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.92966838
91	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.91888388
92	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.91793244
93	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.91761304
94	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.91405934
95	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.91103340
96	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.90998811
97	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.90900406
98	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.89018238
99	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.88825176
100	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.86462570

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009697_abnormal_copulation	4.27979832
2	MP0003315_abnormal_perineum_morphology	3.73914071
3	MP0005410_abnormal_fertilization	3.02491691
4	MP0000749_muscle_degeneration	2.63717703
5	MP0010094_abnormal_chromosome_stability	2.55096285
6	MP0004084_abnormal_cardiac_muscle	2.50861064
7	MP0003693_abnormal_embryo_hatching	2.42194963
8	MP0002132_abnormal_respiratory_system	2.41824666
9	MP0000465_gastrointestinal_hemorrhage	2.39404991
10	MP0003806_abnormal_nucleotide_metabolis	2.36197396
11	MP0005451_abnormal_body_composition	2.23195112
12	MP0000537_abnormal_urethra_morphology	2.03920172
13	MP0005330_cardiomyopathy	1.98159371
14	MP0008004_abnormal_stomach_pH	1.97566589
15	MP0003111_abnormal_nucleus_morphology	1.95227985
16	MP0000678_abnormal_parathyroid_gland	1.90968312
17	MP0005058_abnormal_lysosome_morphology	1.90317806
18	MP0003385_abnormal_body_wall	1.81494357
19	MP0005499_abnormal_olfactory_system	1.78942887
20	MP0005394_taste/olfaction_phenotype	1.78942887
21	MP0002160_abnormal_reproductive_system	1.78681154
22	MP0002249_abnormal_larynx_morphology	1.73230598
23	MP0002396_abnormal_hematopoietic_system	1.71257818
24	MP0002877_abnormal_melanocyte_morpholog	1.68101372
25	MP0004272_abnormal_basement_membrane	1.64826322
26	MP0001188_hyperpigmentation	1.64578959
27	MP0002127_abnormal_cardiovascular_syste	1.59123073
28	MP0003077_abnormal_cell_cycle	1.56393320
29	MP0006036_abnormal_mitochondrial_physio	1.55343905
30	MP0004957_abnormal_blastocyst_morpholog	1.54605160
31	MP0005248_abnormal_Harderian_gland	1.54347724
32	MP0004036_abnormal_muscle_relaxation	1.50657537
33	MP0002822_catalepsy	1.50209343
34	MP0000747_muscle_weakness	1.48704758
35	MP0002269_muscular_atrophy	1.45720922
36	MP0000751_myopathy	1.43920610
37	MP0008932_abnormal_embryonic_tissue	1.43271866
38	MP0000681_abnormal_thyroid_gland	1.42615840
39	MP0005187_abnormal_penis_morphology	1.38517086
40	MP0003698_abnormal_male_reproductive	1.38367832
41	MP0008058_abnormal_DNA_repair	1.38273580
42	MP0001929_abnormal_gametogenesis	1.37780170
43	MP0008007_abnormal_cellular_replicative	1.33658120
44	MP0000759_abnormal_skeletal_muscle	1.32292672
45	MP0003567_abnormal_fetal_cardiomyocyte	1.29693598
46	MP0001664_abnormal_digestion	1.24573857
47	MP0004087_abnormal_muscle_fiber	1.21691982
48	MP0010630_abnormal_cardiac_muscle	1.20750424
49	MP0010368_abnormal_lymphatic_system	1.20492254
50	MP0009250_abnormal_appendicular_skeleto	1.19294010
51	MP0004197_abnormal_fetal_growth/weight/	1.18899263
52	MP0006072_abnormal_retinal_apoptosis	1.17684676
53	MP0009278_abnormal_bone_marrow	1.16324602
54	MP0008789_abnormal_olfactory_epithelium	1.15938538
55	MP0002080_prenatal_lethality	1.12679835
56	MP0001849_ear_inflammation	1.12302325
57	MP0002837_dystrophic_cardiac_calcinosis	1.11635684
58	MP0001730_embryonic_growth_arrest	1.09167569
59	MP0000462_abnormal_digestive_system	1.08685954
60	MP0005397_hematopoietic_system_phenotyp	1.06925451
61	MP0001545_abnormal_hematopoietic_system	1.06925451
62	MP0005076_abnormal_cell_differentiation	1.06078841
63	MP0004233_abnormal_muscle_weight	1.05819865
64	MP0000733_abnormal_muscle_development	1.02343328
65	MP0001348_abnormal_lacrimal_gland	1.00617681
66	MP0004808_abnormal_hematopoietic_stem	0.97573943
67	MP0001529_abnormal_vocalization	0.97166505
68	MP0008775_abnormal_heart_ventricle	0.96333866
69	MP0002108_abnormal_muscle_morphology	0.94112382
70	MP0000049_abnormal_middle_ear	0.93588509
71	MP0002161_abnormal_fertility/fecundity	0.89730828
72	MP0004134_abnormal_chest_morphology	0.89720138
73	MP0006138_congestive_heart_failure	0.89679655
74	MP0003656_abnormal_erythrocyte_physiolo	0.89085006
75	MP0001672_abnormal_embryogenesis/_devel	0.88618592
76	MP0005380_embryogenesis_phenotype	0.88618592
77	MP0002086_abnormal_extraembryonic_tissu	0.87808001
78	MP0004145_abnormal_muscle_electrophysio	0.87674197
79	MP0001145_abnormal_male_reproductive	0.87511920
80	MP0004264_abnormal_extraembryonic_tissu	0.86980049
81	MP0005647_abnormal_sex_gland	0.85609136
82	MP0002234_abnormal_pharynx_morphology	0.84112157
83	MP0001697_abnormal_embryo_size	0.83533402
84	MP0003984_embryonic_growth_retardation	0.83482080
85	MP0000313_abnormal_cell_death	0.82523345
86	MP0000350_abnormal_cell_proliferation	0.82166428
87	MP0003136_yellow_coat_color	0.81662623
88	MP0006035_abnormal_mitochondrial_morpho	0.80140315
89	MP0003935_abnormal_craniofacial_develop	0.79536819
90	MP0005620_abnormal_muscle_contractility	0.78900214
91	MP0004215_abnormal_myocardial_fiber	0.77991620
92	MP0002114_abnormal_axial_skeleton	0.77530352
93	MP0002088_abnormal_embryonic_growth/wei	0.77434516
94	MP0002085_abnormal_embryonic_tissue	0.76664005
95	MP0008995_early_reproductive_senescence	0.76045762
96	MP0001661_extended_life_span	0.74992590
97	MP0001905_abnormal_dopamine_level	0.74506007
98	MP0000653_abnormal_sex_gland	0.73653519
99	MP0002210_abnormal_sex_determination	0.73537387
100	MP0005171_absent_coat_pigmentation	0.73034445

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the columella (HP:0009929)	5.19897887
2	Resting tremor (HP:0002322)	4.07735885
3	Centrally nucleated skeletal muscle fibers (HP:0003687)	4.00568252
4	Reduced antithrombin III activity (HP:0001976)	3.77697361
5	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	3.74941207
6	Exercise-induced myalgia (HP:0003738)	3.67693448
7	Hypoplasia of the uterus (HP:0000013)	3.50924949
8	Acute lymphatic leukemia (HP:0006721)	3.47245076
9	Urinary urgency (HP:0000012)	3.47161741
10	Rimmed vacuoles (HP:0003805)	3.44187487
11	Scapular winging (HP:0003691)	3.39400867
12	Self-mutilation (HP:0000742)	3.21634724
13	Thoracic kyphosis (HP:0002942)	3.15319941
14	Retinal dysplasia (HP:0007973)	3.06459874
15	Hyporeflexia of lower limbs (HP:0002600)	3.05041158
16	Spinal rigidity (HP:0003306)	2.93581042
17	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	2.92651943
18	High anterior hairline (HP:0009890)	2.91480752
19	Abnormality of the shoulder girdle musculature (HP:0001435)	2.90575823
20	Abnormality of the thoracic spine (HP:0100711)	2.82191015
21	Abnormality of the frontal sinuses (HP:0002687)	2.77318604
22	Gonadal dysgenesis (HP:0000133)	2.62369199
23	Abnormality of the tricuspid valve (HP:0001702)	2.54999589
24	Cerebellar dysplasia (HP:0007033)	2.48585718
25	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.39036244
26	Truncus arteriosus (HP:0001660)	2.38986014
27	Abnormality of lateral ventricle (HP:0030047)	2.35608612
28	Right ventricular cardiomyopathy (HP:0011663)	2.33292849
29	EMG: myopathic abnormalities (HP:0003458)	2.33130200
30	Hyperthyroidism (HP:0000836)	2.24872519
31	Increased variability in muscle fiber diameter (HP:0003557)	2.21750204
32	Exercise-induced muscle cramps (HP:0003710)	2.19469198
33	Sudden death (HP:0001699)	2.18067522
34	Ventricular fibrillation (HP:0001663)	2.16784411
35	Clumsiness (HP:0002312)	2.15309430
36	Abnormality of the calf musculature (HP:0001430)	2.13835484
37	Myoglobinuria (HP:0002913)	2.13745619
38	Bowel incontinence (HP:0002607)	2.13462476
39	Abnormal sex determination (HP:0012244)	2.13086365
40	Sex reversal (HP:0012245)	2.13086365
41	Medulloblastoma (HP:0002885)	2.12812694
42	Rhabdomyolysis (HP:0003201)	2.10896914
43	Abnormality of skeletal muscle fiber size (HP:0012084)	2.07858780
44	Aplasia/hypoplasia of the uterus (HP:0008684)	2.06425230
45	High pitched voice (HP:0001620)	2.04879588
46	Back pain (HP:0003418)	2.04051392
47	Abnormality of the intrinsic pathway (HP:0010989)	2.04047484
48	B lymphocytopenia (HP:0010976)	2.01175160
49	Calf muscle hypertrophy (HP:0008981)	2.00681878
50	Hyperacusis (HP:0010780)	2.00185324
51	Neck muscle weakness (HP:0000467)	1.98439370
52	Reticulocytosis (HP:0001923)	1.98284853
53	Granulocytopenia (HP:0001913)	1.98209299
54	Spinal cord lesions (HP:0100561)	1.95711949
55	Syringomyelia (HP:0003396)	1.95711949
56	Abnormal large intestine physiology (HP:0012700)	1.95587229
57	Progressive muscle weakness (HP:0003323)	1.92754769
58	Chromsome breakage (HP:0040012)	1.92291603
59	Capillary hemangiomas (HP:0005306)	1.90971817
60	Abnormal protein glycosylation (HP:0012346)	1.90637202
61	Abnormal glycosylation (HP:0012345)	1.90637202
62	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.90637202
63	Abnormal protein N-linked glycosylation (HP:0012347)	1.90637202
64	Facial hemangioma (HP:0000329)	1.90278354
65	Steppage gait (HP:0003376)	1.89826625
66	Increased mean platelet volume (HP:0011877)	1.89113954
67	Type II lissencephaly (HP:0007260)	1.87057618
68	Foot dorsiflexor weakness (HP:0009027)	1.86017787
69	Easy fatigability (HP:0003388)	1.84769258
70	Colitis (HP:0002583)	1.83445521
71	Sensory axonal neuropathy (HP:0003390)	1.82406757
72	Protruding tongue (HP:0010808)	1.82206766
73	Thyroid-stimulating hormone excess (HP:0002925)	1.81442476
74	Anteriorly placed anus (HP:0001545)	1.80553561
75	Slender long bone (HP:0003100)	1.80252287
76	Proximal placement of thumb (HP:0009623)	1.80073133
77	Deviation of the thumb (HP:0009603)	1.79031407
78	Increased muscle lipid content (HP:0009058)	1.77904161
79	Limb-girdle muscle atrophy (HP:0003797)	1.77379158
80	Aortic aneurysm (HP:0004942)	1.76591158
81	Postural instability (HP:0002172)	1.76573450
82	Muscular dystrophy (HP:0003560)	1.76454224
83	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.74995482
84	Abnormality of the foot musculature (HP:0001436)	1.74341675
85	Muscle hypertrophy of the lower extremities (HP:0008968)	1.73359218
86	Aplasia cutis congenita (HP:0001057)	1.73048130
87	Breech presentation (HP:0001623)	1.72745369
88	Proximal amyotrophy (HP:0007126)	1.71786725
89	Decreased lacrimation (HP:0000633)	1.71316926
90	Alacrima (HP:0000522)	1.71277771
91	Deep palmar crease (HP:0006191)	1.70871066
92	Squamous cell carcinoma (HP:0002860)	1.68363966
93	Bulbar palsy (HP:0001283)	1.66966699
94	Knee flexion contracture (HP:0006380)	1.64496302
95	Germ cell neoplasia (HP:0100728)	1.63873546
96	Diaphragmatic weakness (HP:0009113)	1.63763113
97	Long eyelashes (HP:0000527)	1.60127670
98	Ragged-red muscle fibers (HP:0003200)	1.59893544
99	Elbow flexion contracture (HP:0002987)	1.59687396
100	Abnormality of subcutaneous fat tissue (HP:0001001)	1.59280188

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	7.34637512
2	LATS1	3.39826184
3	MARK3	3.36330376
4	EEF2K	2.83970872
5	NEK2	2.80833283
6	PBK	2.77145070
7	NME2	2.70992774
8	OBSCN	2.69420024
9	FLT3	2.00812059
10	PKN2	1.96649311
11	CDK12	1.83189047
12	MAP2K7	1.75437338
13	LATS2	1.74860617
14	EIF2AK3	1.72886387
15	MYLK	1.68262418
16	ICK	1.67021028
17	CCNB1	1.63875766
18	CSNK1G3	1.51121919
19	TRIB3	1.51035821
20	MST1R	1.50289677
21	CLK1	1.48870563
22	ZAK	1.40250815
23	CDK3	1.38463694
24	CSNK1A1L	1.35042770
25	PLK4	1.33124277
26	SCYL2	1.21444885
27	RPS6KA4	1.20579583
28	RPS6KA5	1.19055793
29	DYRK3	1.13256739
30	BUB1	1.12400453
31	CDK7	1.11925015
32	CDK8	1.09834837
33	STK38	1.05151742
34	CSNK1G1	1.01880530
35	AURKB	1.00355413
36	BRAF	0.99605672
37	IRAK2	0.99385230
38	VRK2	0.98541964
39	SMG1	0.97122157
40	CSNK1G2	0.96811620
41	BRD4	0.95872176
42	STK38L	0.94173744
43	IRAK3	0.92971156
44	MTOR	0.91107805
45	TESK2	0.90847646
46	RPS6KB2	0.90054430
47	RAF1	0.86496797
48	MAPKAPK3	0.85841228
49	MELK	0.83674845
50	PIM2	0.81878808
51	AKT2	0.80509985
52	CDK14	0.80461582
53	PAK2	0.80396006
54	ARAF	0.79808586
55	WEE1	0.78253641
56	VRK1	0.77669520
57	MAPKAPK5	0.77509403
58	TTK	0.74250532
59	MET	0.74180645
60	EIF2AK1	0.71806933
61	NEK1	0.71071503
62	PAK1	0.66593570
63	AURKA	0.66368709
64	CDC7	0.65974572
65	TLK1	0.64637691
66	MAP3K10	0.64535844
67	CDK9	0.63389009
68	GRK6	0.60865390
69	AKT3	0.60811265
70	MAP3K5	0.59518282
71	ATR	0.59229885
72	MAP3K1	0.58691657
73	DAPK3	0.53781666
74	TAF1	0.51089608
75	ATM	0.50347319
76	PLK1	0.49600448
77	RPS6KB1	0.48159930
78	CDK4	0.47324534
79	MAP3K8	0.46884293
80	CHEK2	0.45477399
81	PDGFRA	0.44487338
82	CHEK1	0.43779670
83	SIK1	0.43710372
84	MAPK11	0.43102345
85	SRPK1	0.41758600
86	MAP3K7	0.41560068
87	ILK	0.40746512
88	PRPF4B	0.39985140
89	RET	0.37920036
90	CDK15	0.36098164
91	CDK1	0.35413785
92	MOS	0.35290806
93	MAP3K4	0.33405670
94	MAP3K9	0.32412263
95	KSR2	0.32275434
96	PRKG2	0.31926181
97	CDK18	0.31373945
98	PAK4	0.31351633
99	CDK6	0.30618561
100	DAPK1	0.30116566

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	3.04892921
2	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	2.53118147
3	Gap junction_Homo sapiens_hsa04540	2.36614914
4	Pentose phosphate pathway_Homo sapiens_hsa00030	2.36195238
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.18970486
6	Base excision repair_Homo sapiens_hsa03410	2.11883442
7	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	2.01481522
8	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.70432209
9	Alcoholism_Homo sapiens_hsa05034	1.66274726
10	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.65840357
11	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.60567801
12	Melanoma_Homo sapiens_hsa05218	1.57031534
13	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.54053165
14	Pyrimidine metabolism_Homo sapiens_hsa00240	1.53743227
15	Cell cycle_Homo sapiens_hsa04110	1.51278984
16	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.47848165
17	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.46924341
18	Carbon metabolism_Homo sapiens_hsa01200	1.46856177
19	RNA transport_Homo sapiens_hsa03013	1.44704165
20	Mismatch repair_Homo sapiens_hsa03430	1.41936845
21	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.39468980
22	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.38201158
23	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.37868561
24	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.37376128
25	mRNA surveillance pathway_Homo sapiens_hsa03015	1.36243536
26	Pyruvate metabolism_Homo sapiens_hsa00620	1.34127085
27	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.32497751
28	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.31356872
29	Spliceosome_Homo sapiens_hsa03040	1.31208124
30	Purine metabolism_Homo sapiens_hsa00230	1.30921286
31	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.28444282
32	Nucleotide excision repair_Homo sapiens_hsa03420	1.26525600
33	Glutathione metabolism_Homo sapiens_hsa00480	1.25375554
34	Bladder cancer_Homo sapiens_hsa05219	1.18575831
35	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.10524096
36	AMPK signaling pathway_Homo sapiens_hsa04152	1.09448815
37	Non-small cell lung cancer_Homo sapiens_hsa05223	1.08451215
38	Fanconi anemia pathway_Homo sapiens_hsa03460	1.08179317
39	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.07582631
40	Non-homologous end-joining_Homo sapiens_hsa03450	1.06380366
41	Olfactory transduction_Homo sapiens_hsa04740	1.05550708
42	Apoptosis_Homo sapiens_hsa04210	1.04579749
43	Acute myeloid leukemia_Homo sapiens_hsa05221	1.04100459
44	Propanoate metabolism_Homo sapiens_hsa00640	1.04037618
45	Endometrial cancer_Homo sapiens_hsa05213	1.02595051
46	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.00586250
47	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.00258017
48	Oocyte meiosis_Homo sapiens_hsa04114	0.99145451
49	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.98129065
50	Basal transcription factors_Homo sapiens_hsa03022	0.92957658
51	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.92461910
52	Thyroid cancer_Homo sapiens_hsa05216	0.91427244
53	ECM-receptor interaction_Homo sapiens_hsa04512	0.89687401
54	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.89130249
55	Homologous recombination_Homo sapiens_hsa03440	0.89083506
56	Butanoate metabolism_Homo sapiens_hsa00650	0.85344538
57	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.83941238
58	Arginine biosynthesis_Homo sapiens_hsa00220	0.81923460
59	One carbon pool by folate_Homo sapiens_hsa00670	0.81326568
60	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.81285625
61	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.76217292
62	Glioma_Homo sapiens_hsa05214	0.73466285
63	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.73051179
64	Lysine degradation_Homo sapiens_hsa00310	0.72348715
65	Viral carcinogenesis_Homo sapiens_hsa05203	0.70018165
66	RNA degradation_Homo sapiens_hsa03018	0.68071646
67	Tyrosine metabolism_Homo sapiens_hsa00350	0.67538949
68	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.65867569
69	Glucagon signaling pathway_Homo sapiens_hsa04922	0.65480612
70	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.65216552
71	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.59898260
72	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.59752174
73	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.59492650
74	Small cell lung cancer_Homo sapiens_hsa05222	0.59231776
75	Focal adhesion_Homo sapiens_hsa04510	0.58957272
76	Prostate cancer_Homo sapiens_hsa05215	0.58349027
77	Regulation of autophagy_Homo sapiens_hsa04140	0.58198929
78	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.57563357
79	Pancreatic cancer_Homo sapiens_hsa05212	0.57331906
80	Folate biosynthesis_Homo sapiens_hsa00790	0.56283974
81	Circadian rhythm_Homo sapiens_hsa04710	0.54811438
82	Galactose metabolism_Homo sapiens_hsa00052	0.54565960
83	Insulin signaling pathway_Homo sapiens_hsa04910	0.54435833
84	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.53018587
85	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.51782539
86	MicroRNAs in cancer_Homo sapiens_hsa05206	0.50713825
87	Phenylalanine metabolism_Homo sapiens_hsa00360	0.50177939
88	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.48231062
89	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.47075180
90	Sulfur relay system_Homo sapiens_hsa04122	0.46242315
91	Platelet activation_Homo sapiens_hsa04611	0.45382297
92	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.42606872
93	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.42561719
94	mTOR signaling pathway_Homo sapiens_hsa04150	0.42033645
95	FoxO signaling pathway_Homo sapiens_hsa04068	0.41985968
96	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.41775538
97	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.41734062
98	Colorectal cancer_Homo sapiens_hsa05210	0.41385799
99	RNA polymerase_Homo sapiens_hsa03020	0.38780857
100	Metabolic pathways_Homo sapiens_hsa01100	0.37812330

ZNRF2P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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