ZNRF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.29436847
2negative regulation of transcription by competitive promoter binding (GO:0010944)5.65300620
3telomere maintenance via semi-conservative replication (GO:0032201)5.57888820
4negative regulation of myotube differentiation (GO:0010832)5.54078413
5respiratory chain complex IV assembly (GO:0008535)5.22051940
6negative regulation of granulocyte differentiation (GO:0030853)5.19767478
7ribosome assembly (GO:0042255)4.86122243
8telomere maintenance via recombination (GO:0000722)4.69300957
9GDP-mannose metabolic process (GO:0019673)4.58853067
10DNA strand elongation involved in DNA replication (GO:0006271)4.53069722
11tongue development (GO:0043586)4.48011452
12mannosylation (GO:0097502)4.38531961
13myeloid leukocyte mediated immunity (GO:0002444)4.36390965
14DNA strand elongation (GO:0022616)4.36245124
15ribosomal small subunit assembly (GO:0000028)4.32714568
16regulation of cellular respiration (GO:0043457)4.29974810
17DNA replication initiation (GO:0006270)4.20645971
18endothelium development (GO:0003158)4.11501601
19cytochrome complex assembly (GO:0017004)4.10596214
20neutrophil mediated immunity (GO:0002446)4.01183471
21mitotic recombination (GO:0006312)4.00557484
22SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.92344735
23facial nerve structural organization (GO:0021612)3.92315462
24dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.90175041
25postsynaptic membrane organization (GO:0001941)3.86181452
26deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.86108321
27viral transcription (GO:0019083)3.85976536
28C-terminal protein lipidation (GO:0006501)3.85092358
29cotranslational protein targeting to membrane (GO:0006613)3.83311341
30protein targeting to ER (GO:0045047)3.79053256
31telomere maintenance via telomere lengthening (GO:0010833)3.74341642
32disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.71057399
33killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.71057399
34translational termination (GO:0006415)3.70019214
35ribosomal small subunit biogenesis (GO:0042274)3.65543653
36protein localization to endoplasmic reticulum (GO:0070972)3.65231317
37generation of neurons (GO:0048699)3.62177410
38positive regulation of cellular amine metabolic process (GO:0033240)3.61909421
39establishment of protein localization to endoplasmic reticulum (GO:0072599)3.56013500
40GPI anchor biosynthetic process (GO:0006506)3.55726340
41regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.54192139
42protein heterotetramerization (GO:0051290)3.52377003
43lymphoid progenitor cell differentiation (GO:0002320)3.51339298
44regulation of pigment cell differentiation (GO:0050932)3.48911332
45negative regulation of growth of symbiont in host (GO:0044130)3.45093977
46negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.45093977
47modulation of growth of symbiont involved in interaction with host (GO:0044144)3.45093977
48regulation of growth of symbiont in host (GO:0044126)3.45093977
49pseudouridine synthesis (GO:0001522)3.38124412
50mesonephros development (GO:0001823)3.37471207
51regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.33618251
52negative regulation of metanephros development (GO:0072217)3.32707298
53paraxial mesoderm development (GO:0048339)3.29189588
54notochord development (GO:0030903)3.28510022
55pattern specification involved in kidney development (GO:0061004)3.27126247
56mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.25177792
57regulation of apoptotic process involved in morphogenesis (GO:1902337)3.23570578
58positive regulation of protein export from nucleus (GO:0046827)3.23477128
59proteasome assembly (GO:0043248)3.22778009
60C-terminal protein amino acid modification (GO:0018410)3.19236478
61presynaptic membrane assembly (GO:0097105)3.18941785
62signal peptide processing (GO:0006465)3.18440126
63dorsal/ventral axis specification (GO:0009950)3.18295718
64nephron tubule formation (GO:0072079)3.17531379
65negative regulation of phagocytosis (GO:0050765)3.17346370
66negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.12177380
67negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.11990585
68translational elongation (GO:0006414)3.11316297
69regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.11221636
70maturation of SSU-rRNA (GO:0030490)3.08869751
71positive regulation of dendritic spine morphogenesis (GO:0061003)3.07623939
72androgen biosynthetic process (GO:0006702)3.04909503
73nucleotide-excision repair, DNA gap filling (GO:0006297)3.01912818
74platelet dense granule organization (GO:0060155)3.01909612
75developmental pigmentation (GO:0048066)3.01699696
76limb bud formation (GO:0060174)2.98445969
77viral genome replication (GO:0019079)2.97107529
78L-fucose catabolic process (GO:0042355)2.96011840
79fucose catabolic process (GO:0019317)2.96011840
80L-fucose metabolic process (GO:0042354)2.96011840
81ribosomal large subunit biogenesis (GO:0042273)2.94602405
82lung-associated mesenchyme development (GO:0060484)2.94416912
83GPI anchor metabolic process (GO:0006505)2.92220568
84regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.92195308
85DNA replication checkpoint (GO:0000076)2.88321805
86pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.86162345
87positive regulation of catenin import into nucleus (GO:0035413)2.86161164
88heme biosynthetic process (GO:0006783)2.82894099
89cranial nerve morphogenesis (GO:0021602)2.82845879
90urogenital system development (GO:0001655)2.80470699
91* regulation of non-canonical Wnt signaling pathway (GO:2000050)2.80435560
92mesenchymal cell proliferation (GO:0010463)2.79514992
93viral life cycle (GO:0019058)2.78284021
94midbrain development (GO:0030901)2.77873762
95negative regulation of astrocyte differentiation (GO:0048712)2.77313235
96translational initiation (GO:0006413)2.77187843
97GMP metabolic process (GO:0046037)2.76516444
98mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.74329489
99mitochondrial respiratory chain complex I assembly (GO:0032981)2.74329489
100NADH dehydrogenase complex assembly (GO:0010257)2.74329489
101killing of cells of other organism (GO:0031640)2.73980612
102disruption of cells of other organism (GO:0044364)2.73980612
103G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.73561072
104exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.73060492
105response to interferon-beta (GO:0035456)2.72948296
106positive regulation of glycoprotein biosynthetic process (GO:0010560)2.71471346
107cranial nerve structural organization (GO:0021604)2.71276804
108regulation of mesenchymal cell apoptotic process (GO:2001053)2.68876549
109translation (GO:0006412)2.68662768
110presynaptic membrane organization (GO:0097090)2.67000808
111regulation of granulocyte differentiation (GO:0030852)2.66312463
112pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.64654359
113cellular protein complex disassembly (GO:0043624)2.63035726
114intra-S DNA damage checkpoint (GO:0031573)2.62792799
115tRNA methylation (GO:0030488)2.62686851
116ribonucleoprotein complex biogenesis (GO:0022613)2.62031767
117lung epithelium development (GO:0060428)2.61366614
118secondary heart field specification (GO:0003139)2.61294188
119heart field specification (GO:0003128)2.61294188
120embryonic retina morphogenesis in camera-type eye (GO:0060059)2.57855240
121regulation of catenin import into nucleus (GO:0035412)2.56527813
122cranial suture morphogenesis (GO:0060363)2.53439640
123craniofacial suture morphogenesis (GO:0097094)2.52224154
124nephron tubule morphogenesis (GO:0072078)2.50241744
125nephron epithelium morphogenesis (GO:0072088)2.50241744
126negative regulation of catenin import into nucleus (GO:0035414)2.50064716
127planar cell polarity pathway involved in neural tube closure (GO:0090179)2.49358942
128embryonic foregut morphogenesis (GO:0048617)2.48637038
129cellular response to cholesterol (GO:0071397)2.46334540
130C4-dicarboxylate transport (GO:0015740)2.44864688
131branching involved in salivary gland morphogenesis (GO:0060445)2.44577367
132behavioral response to nicotine (GO:0035095)2.42692186
133axon ensheathment in central nervous system (GO:0032291)2.41653399
134central nervous system myelination (GO:0022010)2.41653399
135otic vesicle formation (GO:0030916)2.41085589
136cell-cell signaling involved in cell fate commitment (GO:0045168)2.40301268
137specification of organ identity (GO:0010092)2.40249643
138artery development (GO:0060840)2.40143212
139lateral sprouting from an epithelium (GO:0060601)2.37471011
140convergent extension (GO:0060026)2.36758501
141cell proliferation involved in kidney development (GO:0072111)2.36217018
142somite development (GO:0061053)2.35494122
143cell surface receptor signaling pathway involved in heart development (GO:0061311)2.33967195
144establishment of tissue polarity (GO:0007164)2.29310985
145establishment of planar polarity (GO:0001736)2.29310985
146developmental induction (GO:0031128)2.26029490
147regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.23900174
148neurotransmitter-gated ion channel clustering (GO:0072578)2.23314921
149negative regulation of transcription regulatory region DNA binding (GO:2000678)2.23129307
150thalamus development (GO:0021794)2.20958461
151dorsal/ventral neural tube patterning (GO:0021904)2.20907946
152neuronal stem cell maintenance (GO:0097150)2.20203428
153regulation of sister chromatid cohesion (GO:0007063)2.18874589
154hindlimb morphogenesis (GO:0035137)2.17739503
155eye photoreceptor cell differentiation (GO:0001754)2.15473147
156photoreceptor cell differentiation (GO:0046530)2.15473147
157cranial nerve development (GO:0021545)2.13971933
158organ induction (GO:0001759)2.13570338
159* non-canonical Wnt signaling pathway (GO:0035567)2.13076922
160regulation of posttranscriptional gene silencing (GO:0060147)2.12909024
161regulation of gene silencing by miRNA (GO:0060964)2.12909024
162regulation of gene silencing by RNA (GO:0060966)2.12909024
163epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.11817548
164negative regulation of glial cell differentiation (GO:0045686)2.11763791
165retinal ganglion cell axon guidance (GO:0031290)2.10262774
166neuron fate determination (GO:0048664)2.10143101
167apical protein localization (GO:0045176)2.09027854
168positive regulation of meiosis (GO:0045836)2.07933552
169spinal cord development (GO:0021510)2.06303250
170renal system development (GO:0072001)2.05204255
171regulation of hippo signaling (GO:0035330)2.04611925
172cell proliferation involved in metanephros development (GO:0072203)2.04135296
173* Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.03212567
174axonal fasciculation (GO:0007413)2.02030128
175embryonic hindlimb morphogenesis (GO:0035116)2.01176106
176dendritic spine morphogenesis (GO:0060997)2.00596257
177positive regulation of meiotic cell cycle (GO:0051446)1.99769350
178SMAD protein signal transduction (GO:0060395)1.99253546
179short-term memory (GO:0007614)1.98558211
180dopaminergic neuron differentiation (GO:0071542)1.97606226
181ephrin receptor signaling pathway (GO:0048013)1.95730755
182kidney morphogenesis (GO:0060993)1.92562412
183prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060521.92364594
184epithelial tube branching involved in lung morphogenesis (GO:0060441)1.91802539
185ectodermal placode formation (GO:0060788)1.91506318
186negative regulation of axon guidance (GO:1902668)1.90455238
187axis elongation (GO:0003401)1.89975698
188hair follicle development (GO:0001942)1.89492248
189regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901211.89420931
190* regulation of establishment of planar polarity (GO:0090175)1.89109095
191positive regulation of smoothened signaling pathway (GO:0045880)1.88999462
192regulation of cell proliferation involved in heart morphogenesis (GO:2000136)1.88711714
193negative regulation of epidermis development (GO:0045683)1.87945024
194cellular response to sterol (GO:0036315)1.87886901
195regulation of bile acid biosynthetic process (GO:0070857)1.87429887

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.94801242
2E2F7_22180533_ChIP-Seq_HELA_Human5.72489553
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.66970298
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.48389042
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.44371781
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.39944658
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.27754155
8RBPJ_22232070_ChIP-Seq_NCS_Mouse3.22817707
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.08820490
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.06695966
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.95564254
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.94142420
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.79698825
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.74107517
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.57491649
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.56130778
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.54591365
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.50299010
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.49594080
20* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.48723729
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.25359189
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.24374774
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.20909114
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.18711636
25ERG_20887958_ChIP-Seq_HPC-7_Mouse2.14743139
26SRF_21415370_ChIP-Seq_HL-1_Mouse2.13684699
27MYC_19030024_ChIP-ChIP_MESCs_Mouse2.11546316
28FOXM1_23109430_ChIP-Seq_U2OS_Human2.07327514
29* CBX2_27304074_Chip-Seq_ESCs_Mouse2.03335337
30TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.02834573
31VDR_23849224_ChIP-Seq_CD4+_Human1.99227490
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.98752851
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.97729699
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.93484568
35LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.92701952
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.92609167
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.90886937
38SCL_19346495_ChIP-Seq_HPC-7_Human1.90586455
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.88650427
40IGF1R_20145208_ChIP-Seq_DFB_Human1.77725445
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.76812892
42IRF1_19129219_ChIP-ChIP_H3396_Human1.75487774
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.74724961
44MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.72358005
45IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.70444955
46EED_16625203_ChIP-ChIP_MESCs_Mouse1.70244252
47FOXP3_21729870_ChIP-Seq_TREG_Human1.69508883
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69445817
49RNF2_18974828_ChIP-Seq_MESCs_Mouse1.68352376
50EZH2_18974828_ChIP-Seq_MESCs_Mouse1.68352376
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.68199580
52TP63_17297297_ChIP-ChIP_HaCaT_Human1.65293943
53ELK1_19687146_ChIP-ChIP_HELA_Human1.65106782
54AR_21909140_ChIP-Seq_LNCAP_Human1.64920992
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.64804926
56JARID2_20064375_ChIP-Seq_MESCs_Mouse1.63294264
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60536565
58IRF8_22096565_ChIP-ChIP_GC-B_Human1.59065264
59CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.58155584
60SPI1_23547873_ChIP-Seq_NB4_Human1.58079353
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.57361667
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.56460367
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54531156
64RNF2_27304074_Chip-Seq_ESCs_Mouse1.52786856
65RNF2_27304074_Chip-Seq_NSC_Mouse1.52335082
66ZNF274_21170338_ChIP-Seq_K562_Hela1.50722997
67E2F1_18555785_ChIP-Seq_MESCs_Mouse1.50414411
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49729278
69DCP1A_22483619_ChIP-Seq_HELA_Human1.47814859
70AR_21572438_ChIP-Seq_LNCaP_Human1.46057446
71BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45851010
72TTF2_22483619_ChIP-Seq_HELA_Human1.43016720
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42009020
74PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41051467
75SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.39205191
76THAP11_20581084_ChIP-Seq_MESCs_Mouse1.38080105
77CREB1_15753290_ChIP-ChIP_HEK293T_Human1.37466742
78MYC_19079543_ChIP-ChIP_MESCs_Mouse1.36930471
79JARID2_20075857_ChIP-Seq_MESCs_Mouse1.36929086
80MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.36808029
81NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.36576193
82GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.36314153
83SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35781135
84* RING1B_27294783_Chip-Seq_NPCs_Mouse1.33062541
85SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.31220946
86CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.30962626
87FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.30329232
88MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29871463
89SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.29700780
90PIAS1_25552417_ChIP-Seq_VCAP_Human1.29443846
91E2F1_21310950_ChIP-Seq_MCF-7_Human1.29237267
92FLI1_27457419_Chip-Seq_LIVER_Mouse1.28270611
93CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25293426
94STAT4_19710469_ChIP-ChIP_TH1__Mouse1.24948736
95GATA1_22025678_ChIP-Seq_K562_Human1.24341595
96XRN2_22483619_ChIP-Seq_HELA_Human1.23591552
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22985158
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22985158
99LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22887776
100ISL1_27105846_Chip-Seq_CPCs_Mouse1.22065412
101ESR1_15608294_ChIP-ChIP_MCF-7_Human1.22036025
102CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21400798
103SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20807634
104CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.20195277
105STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.18565074
106P300_19829295_ChIP-Seq_ESCs_Human1.16915697
107SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.16312455
108SOX9_26525672_Chip-Seq_HEART_Mouse1.16119906
109ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15458719
110* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.15002130
111MYC_18940864_ChIP-ChIP_HL60_Human1.13511495
112SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.12237515
113CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12052434
114SOX2_16153702_ChIP-ChIP_HESCs_Human1.11382482
115* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.11291336
116GABP_19822575_ChIP-Seq_HepG2_Human1.10972520
117IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.09339864
118TBX3_20139965_ChIP-Seq_MESCs_Mouse1.08704583
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08634169
120TBX3_20139965_ChIP-Seq_ESCs_Mouse1.08170552
121VDR_22108803_ChIP-Seq_LS180_Human1.08029014
122REST_21632747_ChIP-Seq_MESCs_Mouse1.07341648
123TAF15_26573619_Chip-Seq_HEK293_Human1.06552724
124SMAD3_21741376_ChIP-Seq_EPCs_Human1.05987073
125EZH2_27294783_Chip-Seq_ESCs_Mouse1.05253044
126TP53_20018659_ChIP-ChIP_R1E_Mouse1.04008253
127VDR_24763502_ChIP-Seq_THP-1_Human1.03996413
128NFE2_27457419_Chip-Seq_LIVER_Mouse1.03915519
129ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03844752
130* RING1B_27294783_Chip-Seq_ESCs_Mouse1.03562063
131RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02710375
132CDX2_20551321_ChIP-Seq_CACO-2_Human1.01617770
133VDR_21846776_ChIP-Seq_THP-1_Human1.01493875
134ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98426301
135YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98333942
136* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98001067
137MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97901383
138NANOG_16153702_ChIP-ChIP_HESCs_Human0.97755200
139POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97682109
140FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95503432
141POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.95363876
142IRF8_21731497_ChIP-ChIP_J774_Mouse0.95038166
143ELK1_22589737_ChIP-Seq_MCF10A_Human0.94242974
144* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93757409
145AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92089456
146KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91838980
147GATA1_26923725_Chip-Seq_HPCs_Mouse0.91329077
148SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90962207
149SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90903462
150MTF2_20144788_ChIP-Seq_MESCs_Mouse0.90851711
151SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90738610
152TCF3_18692474_ChIP-Seq_MESCs_Mouse0.90174225
153LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90071311
154EZH2_27294783_Chip-Seq_NPCs_Mouse0.89950340
155SUZ12_27294783_Chip-Seq_NPCs_Mouse0.89907224
156PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89886711
157TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89814273
158EP300_21415370_ChIP-Seq_HL-1_Mouse0.89521538
159TCF4_18268006_ChIP-ChIP_LS174T_Human0.88999368
160ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.88359663
161POU5F1_16518401_ChIP-PET_MESCs_Mouse0.87343639
162GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86679849
163CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.86612286
164* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.86521902
165* SMAD4_21799915_ChIP-Seq_A2780_Human0.85985653
166SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.85747575
167* GATA3_21867929_ChIP-Seq_CD8_Mouse0.85203604
168PCGF2_27294783_Chip-Seq_NPCs_Mouse0.84722639
169CIITA_25753668_ChIP-Seq_RAJI_Human0.84611723
170GBX2_23144817_ChIP-Seq_PC3_Human0.84417704
171ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80347279
172FUS_26573619_Chip-Seq_HEK293_Human0.79674919
173MYCN_18555785_ChIP-Seq_MESCs_Mouse0.79507830
174EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.78265097
175PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77608329
176* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.76233164
177ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.76041504
178RUNX1_27457419_Chip-Seq_LIVER_Mouse0.75884751
179TAL1_26923725_Chip-Seq_HPCs_Mouse0.75433290
180STAT3_18555785_Chip-Seq_ESCs_Mouse0.74354666
181YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.74190442
182EWS_26573619_Chip-Seq_HEK293_Human0.74083124
183GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.74075046
184E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.73287049
185TP63_19390658_ChIP-ChIP_HaCaT_Human0.72806843

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.51218068
2MP0001188_hyperpigmentation4.34730324
3MP0005409_darkened_coat_color4.11855675
4MP0005174_abnormal_tail_pigmentation3.85979548
5MP0006292_abnormal_olfactory_placode3.66870840
6MP0003724_increased_susceptibility_to3.32236585
7MP0000015_abnormal_ear_pigmentation3.31357473
8MP0003136_yellow_coat_color2.89452722
9MP0005075_abnormal_melanosome_morpholog2.66629997
10MP0003646_muscle_fatigue2.63887668
11MP0010030_abnormal_orbit_morphology2.56752602
12MP0003122_maternal_imprinting2.38799648
13MP0002095_abnormal_skin_pigmentation2.37401021
14MP0003283_abnormal_digestive_organ2.25991591
15MP0008058_abnormal_DNA_repair2.09462591
16MP0001853_heart_inflammation2.06934719
17MP0002396_abnormal_hematopoietic_system2.05680507
18MP0000537_abnormal_urethra_morphology2.04690465
19MP0003937_abnormal_limbs/digits/tail_de2.03524316
20MP0001986_abnormal_taste_sensitivity2.03454185
21MP0004381_abnormal_hair_follicle2.00609496
22MP0002876_abnormal_thyroid_physiology1.99659045
23MP0000681_abnormal_thyroid_gland1.92841176
24MP0000613_abnormal_salivary_gland1.88564535
25MP0000372_irregular_coat_pigmentation1.86434885
26MP0001293_anophthalmia1.85557350
27MP0002234_abnormal_pharynx_morphology1.81710608
28MP0003763_abnormal_thymus_physiology1.79551124
29MP0003890_abnormal_embryonic-extraembry1.76981678
30MP0003693_abnormal_embryo_hatching1.75897798
31MP0000678_abnormal_parathyroid_gland1.72919581
32MP0000490_abnormal_crypts_of1.70888588
33MP0001835_abnormal_antigen_presentation1.70278200
34MP0000049_abnormal_middle_ear1.69111703
35MP0003303_peritoneal_inflammation1.65234630
36MP0002148_abnormal_hypersensitivity_rea1.63128298
37MP0008260_abnormal_autophagy1.62440001
38MP0002697_abnormal_eye_size1.60210696
39MP0002132_abnormal_respiratory_system1.58635807
40MP0000778_abnormal_nervous_system1.58595913
41MP0010094_abnormal_chromosome_stability1.57740910
42MP0000383_abnormal_hair_follicle1.57133882
43MP0003942_abnormal_urinary_system1.54585086
44MP0009785_altered_susceptibility_to1.53009441
45MP0008057_abnormal_DNA_replication1.52807737
46MP0003119_abnormal_digestive_system1.51548656
47MP0003123_paternal_imprinting1.51218036
48MP0002233_abnormal_nose_morphology1.50972372
49MP0009053_abnormal_anal_canal1.47216068
50MP0008007_abnormal_cellular_replicative1.43938169
51MP0009333_abnormal_splenocyte_physiolog1.42589434
52MP0003121_genomic_imprinting1.36232319
53MP0002177_abnormal_outer_ear1.35323816
54MP0001286_abnormal_eye_development1.34627473
55MP0003436_decreased_susceptibility_to1.34285375
56MP0000465_gastrointestinal_hemorrhage1.32097333
57MP0003755_abnormal_palate_morphology1.31812581
58MP0005671_abnormal_response_to1.31765070
59MP0005025_abnormal_response_to1.30460139
60MP0004147_increased_porphyrin_level1.28984385
61MP0003385_abnormal_body_wall1.28870756
62MP0004133_heterotaxia1.28851252
63MP0002751_abnormal_autonomic_nervous1.28164307
64MP0002092_abnormal_eye_morphology1.26474830
65MP0002419_abnormal_innate_immunity1.26379485
66MP0010678_abnormal_skin_adnexa1.25230847
67MP0003880_abnormal_central_pattern1.22992256
68MP0003315_abnormal_perineum_morphology1.22616848
69MP0003786_premature_aging1.21352813
70MP0000534_abnormal_ureter_morphology1.20404782
71MP0002160_abnormal_reproductive_system1.20286705
72MP0003861_abnormal_nervous_system1.19903401
73MP0000428_abnormal_craniofacial_morphol1.17510485
74MP0005187_abnormal_penis_morphology1.16171837
75MP0002163_abnormal_gland_morphology1.14133147
76MP0002938_white_spotting1.13009961
77MP0002098_abnormal_vibrissa_morphology1.12949080
78MP0005000_abnormal_immune_tolerance1.12270648
79MP0004270_analgesia1.11516577
80MP0002249_abnormal_larynx_morphology1.11165744
81MP0003935_abnormal_craniofacial_develop1.10925226
82MP0000566_synostosis1.10554955
83MP0005377_hearing/vestibular/ear_phenot1.10431961
84MP0003878_abnormal_ear_physiology1.10431961
85MP0002089_abnormal_postnatal_growth/wei1.09596424
86MP0002111_abnormal_tail_morphology1.08701136
87MP0001346_abnormal_lacrimal_gland1.07788777
88MP0001486_abnormal_startle_reflex1.07357456
89MP0000026_abnormal_inner_ear1.07114152
90MP0002420_abnormal_adaptive_immunity1.06781148
91MP0003879_abnormal_hair_cell1.06774214
92MP0001502_abnormal_circadian_rhythm1.04665620
93MP0001270_distended_abdomen1.04411156
94MP0002638_abnormal_pupillary_reflex1.04346874
95MP0001819_abnormal_immune_cell1.04008103
96MP0000631_abnormal_neuroendocrine_gland1.01856028
97MP0002116_abnormal_craniofacial_bone1.01549155
98MP0002282_abnormal_trachea_morphology1.00557954
99MP0004885_abnormal_endolymph1.00333627
100MP0000462_abnormal_digestive_system1.00225927
101MP0002084_abnormal_developmental_patter0.99482551
102MP0003828_pulmonary_edema0.99409277
103MP0005595_abnormal_vascular_smooth0.98544205
104MP0000955_abnormal_spinal_cord0.98373851
105MP0001299_abnormal_eye_distance/0.97610754
106MP0000647_abnormal_sebaceous_gland0.97588387
107MP0009250_abnormal_appendicular_skeleto0.97409593
108MP0005391_vision/eye_phenotype0.97051430
109MP0002184_abnormal_innervation0.96743297
110MP0001919_abnormal_reproductive_system0.96580122
111MP0002166_altered_tumor_susceptibility0.96155610
112MP0003567_abnormal_fetal_cardiomyocyte0.95575362
113MP0002723_abnormal_immune_serum0.95162321
114MP0000432_abnormal_head_morphology0.94665460
115MP0003938_abnormal_ear_development0.94561715
116MP0005646_abnormal_pituitary_gland0.94126700
117MP0004742_abnormal_vestibular_system0.92817762
118MP0002736_abnormal_nociception_after0.92447532
119MP0009697_abnormal_copulation0.91891762
120MP0000685_abnormal_immune_system0.91837224
121MP0002398_abnormal_bone_marrow0.90575991
122MP0002075_abnormal_coat/hair_pigmentati0.90495100
123MP0005551_abnormal_eye_electrophysiolog0.90406537
124MP0002006_tumorigenesis0.90008228
125MP0005171_absent_coat_pigmentation0.88560085
126MP0000716_abnormal_immune_system0.88335501
127MP0005379_endocrine/exocrine_gland_phen0.88272047
128MP0002085_abnormal_embryonic_tissue0.87841326
129MP0004957_abnormal_blastocyst_morpholog0.87782079
130MP0005257_abnormal_intraocular_pressure0.87454722
131MP0003186_abnormal_redox_activity0.86187143
132MP0002653_abnormal_ependyma_morphology0.86184899
133MP0000689_abnormal_spleen_morphology0.84160089
134MP0002452_abnormal_antigen_presenting0.83494046
135MP0002152_abnormal_brain_morphology0.83382827
136MP0002557_abnormal_social/conspecific_i0.83061657
137MP0001485_abnormal_pinna_reflex0.82557423
138MP0001984_abnormal_olfaction0.82272386
139MP0002102_abnormal_ear_morphology0.82230179
140MP0002009_preneoplasia0.82186632
141MP0001186_pigmentation_phenotype0.82169561
142MP0002933_joint_inflammation0.81965995
143MP0003077_abnormal_cell_cycle0.81773161
144MP0002734_abnormal_mechanical_nocicepti0.80794199
145MP0001529_abnormal_vocalization0.79497384
146MP0005394_taste/olfaction_phenotype0.79233540
147MP0005499_abnormal_olfactory_system0.79233540
148MP0002277_abnormal_respiratory_mucosa0.79219500
149MP0008932_abnormal_embryonic_tissue0.78638414
150MP0003111_abnormal_nucleus_morphology0.78269478
151MP0008789_abnormal_olfactory_epithelium0.77556729
152MP0003195_calcinosis0.77321391
153MP0002752_abnormal_somatic_nervous0.76754162
154MP0001800_abnormal_humoral_immune0.75269775
155MP0000427_abnormal_hair_cycle0.75183077
156MP0001663_abnormal_digestive_system0.74974715
157MP0003115_abnormal_respiratory_system0.74632051
158MP0002429_abnormal_blood_cell0.74307730
159MP0005195_abnormal_posterior_eye0.74012152
160MP0003941_abnormal_skin_development0.73865253
161MP0000516_abnormal_urinary_system0.73368214
162MP0005367_renal/urinary_system_phenotyp0.73368214
163MP0002932_abnormal_joint_morphology0.71763071
164MP0002722_abnormal_immune_system0.71417343
165MP0003718_maternal_effect0.71119228
166MP0003635_abnormal_synaptic_transmissio0.71002226
167MP0000858_altered_metastatic_potential0.70923947
168MP0001968_abnormal_touch/_nociception0.70818506
169MP0003866_abnormal_defecation0.70266498
170MP0002064_seizures0.69801806
171MP0010155_abnormal_intestine_physiology0.66887692
172MP0005389_reproductive_system_phenotype0.66459296
173MP0002210_abnormal_sex_determination0.64750232
174MP0005464_abnormal_platelet_physiology0.64003095
175MP0000762_abnormal_tongue_morphology0.63692474
176MP0004142_abnormal_muscle_tone0.62659402
177MP0001545_abnormal_hematopoietic_system0.62646268
178MP0005397_hematopoietic_system_phenotyp0.62646268
179MP0001119_abnormal_female_reproductive0.62559474
180MP0000579_abnormal_nail_morphology0.60275293

Predicted human phenotypes

RankGene SetZ-score
1Reduced antithrombin III activity (HP:0001976)8.62146561
2Type I transferrin isoform profile (HP:0003642)7.82354198
3Abnormal glycosylation (HP:0012345)5.59300082
4Abnormal isoelectric focusing of serum transferrin (HP:0003160)5.59300082
5Abnormal protein N-linked glycosylation (HP:0012347)5.59300082
6Abnormal protein glycosylation (HP:0012346)5.59300082
7Hypothermia (HP:0002045)4.27708113
8Thyroid-stimulating hormone excess (HP:0002925)3.90305027
9Abnormal number of erythroid precursors (HP:0012131)3.84776229
10Abnormality of the axillary hair (HP:0100134)3.62180071
11Abnormality of secondary sexual hair (HP:0009888)3.62180071
12Annular pancreas (HP:0001734)3.60400577
13Abnormality of cells of the erythroid lineage (HP:0012130)3.59832539
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.58230695
15Severe visual impairment (HP:0001141)3.35041016
16Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.32829380
17Increased hepatocellular lipid droplets (HP:0006565)3.23538621
18Absent rod-and cone-mediated responses on ERG (HP:0007688)3.11694153
19Hepatocellular necrosis (HP:0001404)3.04965282
20Reticulocytopenia (HP:0001896)3.04549001
21Renal Fanconi syndrome (HP:0001994)3.01708537
22Sex reversal (HP:0012245)2.88109178
23Abnormal sex determination (HP:0012244)2.88109178
24Exertional dyspnea (HP:0002875)2.86719875
25Hepatic necrosis (HP:0002605)2.80880856
26Lipid accumulation in hepatocytes (HP:0006561)2.76641255
27Thrombocytosis (HP:0001894)2.75769006
28True hermaphroditism (HP:0010459)2.72125153
29Prolonged partial thromboplastin time (HP:0003645)2.70789139
30Abnormality of magnesium homeostasis (HP:0004921)2.70444893
31Bilateral microphthalmos (HP:0007633)2.70441920
32Hepatoblastoma (HP:0002884)2.69505343
33Thoracic kyphosis (HP:0002942)2.65266674
34Aplasia/Hypoplasia of the sacrum (HP:0008517)2.65221071
35Abnormality of the columella (HP:0009929)2.62960464
36Anophthalmia (HP:0000528)2.60236044
37Elevated erythrocyte sedimentation rate (HP:0003565)2.59690864
38Abnormality of the prostate (HP:0008775)2.57804945
39Midline defect of the nose (HP:0004122)2.48548462
40Partial duplication of thumb phalanx (HP:0009944)2.44924169
41Aplastic anemia (HP:0001915)2.44300563
42Ocular albinism (HP:0001107)2.43402350
43Bronchomalacia (HP:0002780)2.41999523
44Coronal craniosynostosis (HP:0004440)2.41766492
45Dry hair (HP:0011359)2.40545825
46Microvesicular hepatic steatosis (HP:0001414)2.40047158
47Split foot (HP:0001839)2.38078485
48Cortical visual impairment (HP:0100704)2.37099067
49Aplasia involving bones of the upper limbs (HP:0009823)2.37045488
50Aplasia of the phalanges of the hand (HP:0009802)2.37045488
51Aplasia involving bones of the extremities (HP:0009825)2.37045488
52Cutaneous finger syndactyly (HP:0010554)2.32327123
53Preaxial foot polydactyly (HP:0001841)2.29039409
54Esophageal atresia (HP:0002032)2.26682990
55Obstructive sleep apnea (HP:0002870)2.23304314
56Chronic obstructive pulmonary disease (HP:0006510)2.22435789
57Obstructive lung disease (HP:0006536)2.22435789
58Capillary hemangiomas (HP:0005306)2.22368914
59Increased intramyocellular lipid droplets (HP:0012240)2.21741686
60Macrocytic anemia (HP:0001972)2.20996205
61Flat occiput (HP:0005469)2.20490352
62Pulmonary fibrosis (HP:0002206)2.17016905
63Myositis (HP:0100614)2.14554536
64Partial duplication of the phalanx of hand (HP:0009999)2.13642834
65Spinal canal stenosis (HP:0003416)2.13464433
66Abnormal spermatogenesis (HP:0008669)2.10947611
67Respiratory difficulties (HP:0002880)2.09027763
68Microcytic anemia (HP:0001935)2.08282290
69Bifid scrotum (HP:0000048)2.08162329
70Mitral regurgitation (HP:0001653)2.07474858
71Pancreatic fibrosis (HP:0100732)2.06855320
72Trigonocephaly (HP:0000243)2.06595396
73Attenuation of retinal blood vessels (HP:0007843)2.06328216
74Cutaneous syndactyly (HP:0012725)2.03493533
75Rib fusion (HP:0000902)2.01752968
763-Methylglutaconic aciduria (HP:0003535)2.01689617
77Abnormality of the preputium (HP:0100587)2.01596659
78Iris hypopigmentation (HP:0007730)2.01400314
79Ankle contracture (HP:0006466)2.01048230
80Abnormal rod and cone electroretinograms (HP:0008323)2.00780878
81Abnormality of renal resorption (HP:0011038)1.99900461
82Mitochondrial inheritance (HP:0001427)1.99344411
83Vaginal fistula (HP:0004320)1.97284992
84Focal motor seizures (HP:0011153)1.94586504
85Meningitis (HP:0001287)1.93170009
86Duplication of thumb phalanx (HP:0009942)1.92225084
87Pallor (HP:0000980)1.91864227
88Stomatitis (HP:0010280)1.90937412
89Chromosomal breakage induced by crosslinking agents (HP:0003221)1.90791153
90Abnormality of the lacrimal duct (HP:0011481)1.90704715
91IgM deficiency (HP:0002850)1.90469267
92Abnormality of the thoracic spine (HP:0100711)1.89729772
93Lower limb hyperreflexia (HP:0002395)1.89697850
94Choanal stenosis (HP:0000452)1.89636431
95Concave nail (HP:0001598)1.89384133
96Decreased activity of mitochondrial respiratory chain (HP:0008972)1.88745491
97Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.88745491
98Hyperglycinuria (HP:0003108)1.88604508
99Type 2 muscle fiber atrophy (HP:0003554)1.88357600
100Nonprogressive disorder (HP:0003680)1.87675560
101Pancreatic cysts (HP:0001737)1.86541076
102Abnormality of the aortic arch (HP:0012303)1.85627905
103Petechiae (HP:0000967)1.84612919
104Meckel diverticulum (HP:0002245)1.84074029
105Abnormality of the diencephalon (HP:0010662)1.84038842
106Abnormality of cochlea (HP:0000375)1.83673865
107High anterior hairline (HP:0009890)1.82747879
108Alacrima (HP:0000522)1.81925363
109Gastrointestinal atresia (HP:0002589)1.81376779
110Abnormality of DNA repair (HP:0003254)1.81077045
111Abnormality of the labia minora (HP:0012880)1.79869685
112Increased muscle lipid content (HP:0009058)1.79729845
113Abnormality of the parietal bone (HP:0002696)1.79570861
114Microglossia (HP:0000171)1.79242151
115Clubbing of toes (HP:0100760)1.78983005
116Renal hypoplasia (HP:0000089)1.78943265
117Rectovaginal fistula (HP:0000143)1.78360248
118Rectal fistula (HP:0100590)1.78360248
119Abnormality of the middle phalanges of the toes (HP:0010183)1.78287874
120Increased CSF lactate (HP:0002490)1.78006757
121Azoospermia (HP:0000027)1.76603916
122Abnormal number of incisors (HP:0011064)1.75915832
123Chromsome breakage (HP:0040012)1.75257987
124Increased serum lactate (HP:0002151)1.73691249
125Turricephaly (HP:0000262)1.73507689
12611 pairs of ribs (HP:0000878)1.73128679
127Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.72560166
128Abnormality of the ileum (HP:0001549)1.72056679
129Abnormality of the nasolacrimal system (HP:0000614)1.71855571
130Pancytopenia (HP:0001876)1.71357253
131Humeroradial synostosis (HP:0003041)1.70993800
132Synostosis involving the elbow (HP:0003938)1.70993800
133Triphalangeal thumb (HP:0001199)1.69899448
134Muscle fiber atrophy (HP:0100295)1.69222451
135Chronic otitis media (HP:0000389)1.69148441
136Male pseudohermaphroditism (HP:0000037)1.68957664
137Birth length less than 3rd percentile (HP:0003561)1.67826533
138Aplasia/Hypoplasia of the uvula (HP:0010293)1.65282442
139Late onset (HP:0003584)1.64891408
140Abnormality of the nasal septum (HP:0000419)1.64103935
141Overriding aorta (HP:0002623)1.63443942
142Cerebellar dysplasia (HP:0007033)1.63050456
143Missing ribs (HP:0000921)1.62325165
144Oligodactyly (hands) (HP:0001180)1.62144707
145Facial hemangioma (HP:0000329)1.60784021
146Supernumerary spleens (HP:0009799)1.60288306
147Anencephaly (HP:0002323)1.60017495
148Knee flexion contracture (HP:0006380)1.59909643
149Aplasia/Hypoplasia of the sternum (HP:0006714)1.59174220
150Scrotal hypoplasia (HP:0000046)1.59100976
151Gonadal dysgenesis (HP:0000133)1.58936382
152Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.58753618
153Primitive neuroectodermal tumor (HP:0030065)1.58753618
154Absent radius (HP:0003974)1.57011028
155Irregular epiphyses (HP:0010582)1.56374557
156Neonatal short-limb short stature (HP:0008921)1.54988375
157Broad thumb (HP:0011304)1.54789358
158Absent forearm bone (HP:0003953)1.54762640
159Aplasia involving forearm bones (HP:0009822)1.54762640
160Preaxial hand polydactyly (HP:0001177)1.54196998
161Bifid tongue (HP:0010297)1.53301334
162Deep venous thrombosis (HP:0002625)1.53235816
163Abnormality of glycine metabolism (HP:0010895)1.52829048
164Abnormality of serine family amino acid metabolism (HP:0010894)1.52829048
165Absent epiphyses (HP:0010577)1.52644049
166Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.52644049
167Septo-optic dysplasia (HP:0100842)1.52096432
168Abnormal lung lobation (HP:0002101)1.52026187
169Renal duplication (HP:0000075)1.51465487
170Myelomeningocele (HP:0002475)1.50673963
171Nephronophthisis (HP:0000090)1.50618195
172Megalencephaly (HP:0001355)1.50565449
173Increased nuchal translucency (HP:0010880)1.49379317
174Ectopic kidney (HP:0000086)1.49358250
175Short hallux (HP:0010109)1.49083907
176Abnormality of the pubic bones (HP:0003172)1.48510068
177Oligodactyly (HP:0012165)1.48493016
178Abnormality of the vitreous humor (HP:0004327)1.48427695
179Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.48069185
180Nasolacrimal duct obstruction (HP:0000579)1.47944945
181Intestinal fistula (HP:0100819)1.47585949
182Synostosis of carpal bones (HP:0005048)1.47535734
183Pterygium (HP:0001059)1.47410144
184Type II lissencephaly (HP:0007260)1.46833879
185Hypoplasia of the capital femoral epiphysis (HP:0003090)1.44832646
186Absent eyebrow (HP:0002223)1.43941888
187Pendular nystagmus (HP:0012043)1.43142137
188Postaxial foot polydactyly (HP:0001830)1.42998397
189Oligodontia (HP:0000677)1.42235607
190Enlarged kidneys (HP:0000105)1.41690705
191Short 4th metacarpal (HP:0010044)1.40965242
192Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.40965242

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK8.19150522
2EIF2AK37.20625739
3STK163.64592926
4MKNK23.36608475
5NLK3.05843222
6FGFR22.82488306
7CAMKK22.75897422
8EIF2AK22.70099391
9LATS12.69232485
10LATS22.54842718
11STK392.48745079
12WNK42.46978508
13FES2.42013187
14STK38L2.38456114
15EPHA42.26431183
16MKNK12.19533831
17EPHB22.05108206
18IRAK42.02188162
19IRAK31.99174967
20CASK1.99139510
21PNCK1.92665310
22MUSK1.89460854
23PRPF4B1.86971785
24TEC1.75318602
25MARK11.74484812
26WEE11.60000820
27MAP3K101.48087976
28VRK11.45873552
29TYRO31.42417634
30PIM21.41016691
31NME21.39308145
32EPHA21.37458944
33WNK31.37390655
34NEK11.36488390
35TLK11.32961453
36SRPK11.30430029
37CAMK1D1.30005657
38CAMK1G1.29448080
39NEK21.29295508
40EEF2K1.28205684
41NTRK21.25089497
42PBK1.24216031
43TSSK61.24115655
44FGFR11.21587077
45PRKD31.21513826
46FRK1.20161971
47CDK191.18680852
48KIT1.18511792
49ZAK1.15196850
50BUB11.12280796
51MAP2K71.10046719
52TTK1.08196907
53NME11.06355471
54OXSR11.04868306
55PLK31.04638695
56BRSK11.04477604
57STK31.04066661
58YES11.03243697
59AKT30.96068717
60CAMK10.92718323
61MAP3K40.90775083
62FLT30.90534481
63PHKG20.88991285
64PHKG10.88991285
65MAP4K20.86821985
66MET0.85735871
67BTK0.82537827
68TAF10.81354028
69PLK40.80022983
70FGFR40.78447235
71CDK80.77166382
72DYRK20.75340678
73EIF2AK10.75114207
74PRKCG0.74479451
75CDC70.73599352
76TXK0.73499965
77ACVR1B0.71948662
78BLK0.70390566
79PASK0.70110696
80PIK3CA0.69247479
81STK240.69169865
82SIK10.66537713
83TAOK20.66374109
84CDK70.65245451
85CSNK1E0.64909524
86SGK4940.63517617
87SGK2230.63517617
88MELK0.62701472
89MAP3K90.62453288
90MAPK130.62268119
91MAP3K120.62096678
92ADRBK20.60998082
93CLK10.60315016
94NTRK10.60103057
95ERBB20.59663986
96MST1R0.58259691
97ICK0.58148703
98VRK20.58041047
99CDK120.56631849
100SGK20.55317170
101LYN0.55258248
102BRSK20.55066448
103FER0.54945959
104DYRK30.54205961
105PRKG20.54127113
106LMTK20.53726383
107MAP3K140.51104858
108CSNK1G10.50077981
109IRAK10.50049625
110PLK20.49925016
111IRAK20.49485191
112INSRR0.48314239
113SCYL20.47582736
114ATM0.47452446
115ERBB40.47154236
116WNK10.46883485
117CDK10.45625471
118KDR0.45228250
119DMPK0.44757379
120BMPR1B0.44360886
121RPS6KB10.43931816
122FGFR30.43831216
123SYK0.42510993
124ATR0.42031908
125CSF1R0.41746231
126PRKCE0.41527686
127TGFBR10.41407038
128IKBKB0.41169792
129IKBKE0.40459938
130CCNB10.40014691
131CDK30.39225087
132NTRK30.39071010
133PRKDC0.38693873
134CAMKK10.38560306
135CAMK40.38307781
136MAPK150.38162513
137MAPK40.37267718
138MAP4K10.35241904
139MAP3K10.34504030
140LCK0.31524213
141MYLK0.30741726
142RPS6KA40.30508829
143TYK20.30469424
144CSK0.30153942
145BCKDK0.29628000
146CSNK2A10.29553282
147PIK3CG0.28996542
148HIPK20.27388540
149MAP2K30.26716020
150CSNK2A20.26591679
151PINK10.24641049
152DAPK10.24018717
153MATK0.23982889
154PRKD20.23004598
155AURKB0.22533667
156AURKA0.21847896
157PLK10.20833204
158ZAP700.20325116
159PIM10.19720978
160MAPKAPK50.19720046
161BMPR20.19528507
162HCK0.16653363
163TIE10.16023478
164ABL20.15697094
165GRK10.15243515
166NEK60.14463553
167GRK70.14435077
168UHMK10.14178830
169MAP2K60.14068808
170CHEK20.14057972

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.29134969
2Ribosome_Homo sapiens_hsa030104.21404208
3Mismatch repair_Homo sapiens_hsa034303.34002612
4Protein export_Homo sapiens_hsa030603.28600059
5Homologous recombination_Homo sapiens_hsa034402.97632081
6Base excision repair_Homo sapiens_hsa034102.72659324
7N-Glycan biosynthesis_Homo sapiens_hsa005102.57722790
8Fanconi anemia pathway_Homo sapiens_hsa034602.39900485
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.38241956
10Nucleotide excision repair_Homo sapiens_hsa034202.36323199
11Pyrimidine metabolism_Homo sapiens_hsa002402.31327981
12RNA polymerase_Homo sapiens_hsa030202.14002213
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.06517379
14Hedgehog signaling pathway_Homo sapiens_hsa043402.01494730
15Proteasome_Homo sapiens_hsa030502.01234345
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.98442553
17Vitamin B6 metabolism_Homo sapiens_hsa007501.90427420
18Spliceosome_Homo sapiens_hsa030401.88310139
19Thyroid cancer_Homo sapiens_hsa052161.88245745
20Other glycan degradation_Homo sapiens_hsa005111.86242650
21Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.85851211
22Hippo signaling pathway_Homo sapiens_hsa043901.84650893
23Non-homologous end-joining_Homo sapiens_hsa034501.81046071
24Steroid biosynthesis_Homo sapiens_hsa001001.75659776
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72707000
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.70271599
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.66605872
28One carbon pool by folate_Homo sapiens_hsa006701.66449237
29Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.59310264
30Basal transcription factors_Homo sapiens_hsa030221.57502158
31Purine metabolism_Homo sapiens_hsa002301.51137943
32Nicotine addiction_Homo sapiens_hsa050331.50551870
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.48500133
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.46616451
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.44145255
36TGF-beta signaling pathway_Homo sapiens_hsa043501.42950006
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42924789
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.39212315
39Butanoate metabolism_Homo sapiens_hsa006501.35857740
40Fatty acid biosynthesis_Homo sapiens_hsa000611.27032855
41RNA degradation_Homo sapiens_hsa030181.26045364
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.22767078
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21936867
44Renin-angiotensin system_Homo sapiens_hsa046141.21872788
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19096022
46Primary immunodeficiency_Homo sapiens_hsa053401.17107828
47Circadian rhythm_Homo sapiens_hsa047101.15584286
48Nitrogen metabolism_Homo sapiens_hsa009101.13907973
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11298001
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.09653586
51Propanoate metabolism_Homo sapiens_hsa006401.08357104
52Histidine metabolism_Homo sapiens_hsa003401.07570491
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07284668
54Cell cycle_Homo sapiens_hsa041101.04715242
55Axon guidance_Homo sapiens_hsa043601.01746017
56Arginine biosynthesis_Homo sapiens_hsa002201.00956067
57Oxidative phosphorylation_Homo sapiens_hsa001900.99087151
58Lysine degradation_Homo sapiens_hsa003100.97710995
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97389476
60Herpes simplex infection_Homo sapiens_hsa051680.95994178
61Melanogenesis_Homo sapiens_hsa049160.94408399
62Bile secretion_Homo sapiens_hsa049760.92755166
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90978419
64Pyruvate metabolism_Homo sapiens_hsa006200.89833883
65Fatty acid metabolism_Homo sapiens_hsa012120.88362226
66Fat digestion and absorption_Homo sapiens_hsa049750.87968340
67Thyroid hormone synthesis_Homo sapiens_hsa049180.87696870
68p53 signaling pathway_Homo sapiens_hsa041150.86894167
69Sphingolipid metabolism_Homo sapiens_hsa006000.85564973
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85434151
71Selenocompound metabolism_Homo sapiens_hsa004500.84182911
72Sulfur relay system_Homo sapiens_hsa041220.84162077
73Arachidonic acid metabolism_Homo sapiens_hsa005900.83536132
74Folate biosynthesis_Homo sapiens_hsa007900.82965355
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82507861
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82031118
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81577834
78Insulin secretion_Homo sapiens_hsa049110.79798749
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.79429660
80Cocaine addiction_Homo sapiens_hsa050300.79123705
81Tight junction_Homo sapiens_hsa045300.79096429
82Fatty acid degradation_Homo sapiens_hsa000710.78720525
83Malaria_Homo sapiens_hsa051440.77840198
84Systemic lupus erythematosus_Homo sapiens_hsa053220.77684581
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.76683354
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.76656240
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76497769
88Glutamatergic synapse_Homo sapiens_hsa047240.74534987
89Glutathione metabolism_Homo sapiens_hsa004800.73293288
90Taste transduction_Homo sapiens_hsa047420.73111226
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72347564
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.71684440
93Adherens junction_Homo sapiens_hsa045200.71141013
94RNA transport_Homo sapiens_hsa030130.70537062
95mRNA surveillance pathway_Homo sapiens_hsa030150.70438781
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.70105733
97Measles_Homo sapiens_hsa051620.69942779
98Tryptophan metabolism_Homo sapiens_hsa003800.69361039
99beta-Alanine metabolism_Homo sapiens_hsa004100.68088289
100Cardiac muscle contraction_Homo sapiens_hsa042600.67823954
101Hematopoietic cell lineage_Homo sapiens_hsa046400.66442139
102ECM-receptor interaction_Homo sapiens_hsa045120.66359228
103Biosynthesis of amino acids_Homo sapiens_hsa012300.65930284
104Allograft rejection_Homo sapiens_hsa053300.64489611
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.64484586
106Notch signaling pathway_Homo sapiens_hsa043300.63230466
107Complement and coagulation cascades_Homo sapiens_hsa046100.62931459
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62205000
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61991131
110Pentose phosphate pathway_Homo sapiens_hsa000300.60083466
111Asthma_Homo sapiens_hsa053100.59276804
112Parkinsons disease_Homo sapiens_hsa050120.57585867
113Leishmaniasis_Homo sapiens_hsa051400.57406246
114Fatty acid elongation_Homo sapiens_hsa000620.56477329
115Phenylalanine metabolism_Homo sapiens_hsa003600.56148385
116Acute myeloid leukemia_Homo sapiens_hsa052210.55904489
117Phototransduction_Homo sapiens_hsa047440.53707226
1182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53309518
119Amphetamine addiction_Homo sapiens_hsa050310.53114505
120Metabolic pathways_Homo sapiens_hsa011000.52990813
121Retinol metabolism_Homo sapiens_hsa008300.52347133
122Huntingtons disease_Homo sapiens_hsa050160.52307131
123Tyrosine metabolism_Homo sapiens_hsa003500.52220965
124Regulation of autophagy_Homo sapiens_hsa041400.51767910
125Cyanoamino acid metabolism_Homo sapiens_hsa004600.50592362
126Circadian entrainment_Homo sapiens_hsa047130.50169412
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49963164
128Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49135575
129GABAergic synapse_Homo sapiens_hsa047270.49099577
130Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47908877
131Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47873876
132Glucagon signaling pathway_Homo sapiens_hsa049220.47693418
133Drug metabolism - other enzymes_Homo sapiens_hsa009830.46817841
134Protein digestion and absorption_Homo sapiens_hsa049740.44888741
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43123047
136MicroRNAs in cancer_Homo sapiens_hsa052060.42901836
137Vitamin digestion and absorption_Homo sapiens_hsa049770.39391213
138Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38138675
139Autoimmune thyroid disease_Homo sapiens_hsa053200.37658215
140SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37629437
141Jak-STAT signaling pathway_Homo sapiens_hsa046300.37461123
142Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35835366
143Maturity onset diabetes of the young_Homo sapiens_hsa049500.35446544
144Alzheimers disease_Homo sapiens_hsa050100.35348966
145Toll-like receptor signaling pathway_Homo sapiens_hsa046200.34861924
146Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34542559
147NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33872646
148Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33067531
149Epstein-Barr virus infection_Homo sapiens_hsa051690.28630902
150Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28295753
151Galactose metabolism_Homo sapiens_hsa000520.27717768
152Graft-versus-host disease_Homo sapiens_hsa053320.27192708
153Antigen processing and presentation_Homo sapiens_hsa046120.26745343
154Hepatitis B_Homo sapiens_hsa051610.25489262
155ABC transporters_Homo sapiens_hsa020100.24203520
156Pertussis_Homo sapiens_hsa051330.24017962
157Influenza A_Homo sapiens_hsa051640.23326662
158Basal cell carcinoma_Homo sapiens_hsa052170.22369642
159HTLV-I infection_Homo sapiens_hsa051660.21285772
160Arginine and proline metabolism_Homo sapiens_hsa003300.19727621
161Alcoholism_Homo sapiens_hsa050340.18839545
162Wnt signaling pathway_Homo sapiens_hsa043100.17887788
163Legionellosis_Homo sapiens_hsa051340.16780927

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